Cluster 0: cypa inhibitors inducers medications strong cypc cytochrome concomitant study use Cluster 1: requiring infection systemic active therapy intravenous treatment patient patients admission Cluster 2: transaminase aminotransferase serum glutamic pyruvate oxaloacetic glutamate sgot sgpt institutional Cluster 3: mcl neutrophil absolute count registration days weeks prior cohort cells Cluster 4: oncology eastern group performance cooperative status ecog days registration prior Cluster 5: rectal chemoradiation exclude protocol radiotherapy standard marrow bone subject concluded Cluster 6: hemoglobin dl days obtained prior treatment randomization study day cycle Cluster 7: comprehend informed consent able sign document written willing subjects form Cluster 8: treatment prior study weeks days patients months allowed dose trc Cluster 9: incidental tnm ta finding tb prostate cancer carcinoma histologic stage Cluster 10: chemotherapy metastatic prior disease adjuvant regimen received advanced therapy systemic Cluster 11: decompensated arrhythmia congestive heart failure uncontrolled ejection fraction absence left Cluster 12: minute creatinine clearance ml calculated gault serum cockcroft formula measured Cluster 13: dose therapy study male starting method contraception agree adequate use Cluster 14: forms medically sexually acceptable willing contraception able women use childbearing Cluster 15: sites disease metastatic patients measurable radiation primary treatment prior site Cluster 16: anticipated expectancy life months greater weeks time lymphodepletion ecog screening Cluster 17: hiv immunodeficiency virus human known infection positive patients testing infected Cluster 18: eligible patients disease study prior therapy treatment tumor provided criteria Cluster 19: response evaluation solid recist criteria tumors measurable disease evaluable defined Cluster 20: renal hepatic disease significant pulmonary cardiovascular endocrine investigator gastrointestinal metabolic Cluster 21: non older males females age pregnant years breastfeeding lactating available Cluster 22: uncontrolled heart york association nyha iii class iv new failure Cluster 23: platelet mm count cells greater days randomization starting weeks prior Cluster 24: urine pregnancy negative test phase serum ii extension hours randomized Cluster 25: sponge ring jellies vaginal study double diaphragm cream spermicidal contraceptive Cluster 26: obtained registration uln days prior bilirubin creatinine total upper normal Cluster 27: platelets ml days dl consent surgery chemistry documented total study Cluster 28: lactating pregnant subject subjects intending patient non participant woman exclusion Cluster 29: bleeding gastrointestinal months history significant gi hemorrhage clinically prior grade Cluster 30: females feeding breast pregnant feed lactating taking lenalidomide agree study Cluster 31: total bilirubin upper limit normal uln age range serum days Cluster 32: agents investigational receiving patients subjects ineligible patient treatment days registration Cluster 33: cardiac significant clinically disease history uncontrolled dysfunction pulmonary active months Cluster 34: inability comply protocol requirements assessments investigator follow available study willing Cluster 35: carcinoma cell basal local cervix resection exception squamous treated skin Cluster 36: hepatitis hiv known infection active history positive patients viral chronic Cluster 37: bilirubin mg dl direct equal unless ml considered total tumor Cluster 38: counts blood platelet cell mm neutrophil wbc white prior absolute Cluster 39: excluded pregnant women study patients men breastfeeding participating studied trial Cluster 40: neuropathy greater grade peripheral equal patients baseline cause ii severity Cluster 41: breastfeeding pregnant patient lactating stop does agree fancd fascia farber Cluster 42: cns metastases subjects symptoms treated nervous eligible central neurologically stable Cluster 43: karnofsky performance status patients ecog higher days greater registration prior Cluster 44: prostate adenocarcinoma histologically confirmed documented cancer diagnosis biopsy metastatic primary Cluster 45: document willingness understand sign ability written informed consent subject subjects Cluster 46: coronary history heart evidence cardiac angioplasty stenting controlled syndromes including Cluster 47: aminotransferase times uln alanine alt aspartate ast liver hepatic upper Cluster 48: write read english able speak understand unable spanish languages ability Cluster 49: thromboplastin partial ptt time normal upper limit uln times institutional Cluster 50: cancer melanoma skin non years invasive malignancies situ past history Cluster 51: eastern cooperative oncology group ecog performance status patients subject clinical Cluster 52: written informed consent given provides obtained able participate patient study Cluster 53: diverticulosis crohns colitis diarrhea ulcerative enroll gi disease inflammatory bowel Cluster 54: graft hematopoietic stem study participation entry agents received cell patient Cluster 55: adverse ae sodium potassium calcium values event terminology common version Cluster 56: swallow oral able medications patients patient reliably tolerate capsules absorb Cluster 57: uncontrolled infection active systemic patients time subject transplantation patient enrollment Cluster 58: cm measurable ct dimension disease longest lesion tomography computed scan Cluster 59: delayed toxicity chemotherapy weekly therapy immunotherapy biologic extensive weeks days Cluster 60: stem transplant cell autologous received prior patients asct therapy chemotherapy Cluster 61: transplantation solid organ received eligible prior patients history hsct tuberculosis Cluster 62: illness uncontrolled heart social compliance psychiatric congestive pectoris failure situations Cluster 63: extramedullary isolated disease cns relapse leukemia testicular solitary marrow bone Cluster 64: play lansky score performance karnofsky scale pediatric status years older Cluster 65: ms qtc qt corrected interval baseline ecg prolongation males electrocardiogram Cluster 66: conducted assessed renal liver laboratory adequate marrow bone function following Cluster 67: brain metastases steroids requiring symptomatic symptoms known control patients require Cluster 68: measurable disease non patients subjects presence site allowed defined metastatic Cluster 69: expecting conceive trial projected screening children father visit breastfeeding duration Cluster 70: tuberculosis tb known history bacillus active mycobacterium patients infection appropriately Cluster 71: hepatitis hbsag positive surface antigen test antibody virus hcv hbcab Cluster 72: current hepatitis virus liver alcohol abuse cirrhosis history clinically significant Cluster 73: bowels stomach alter retain malabsorption absorption abnormalities swallow resection gastrointestinal Cluster 74: age years patients patient subject participants subjects months women greater Cluster 75: reversible effects recovered toxicity grade fully failure prior chemotherapy therapy Cluster 76: containing platinum regimen chemotherapy progression prior therapy cisplatin disease treatment Cluster 77: antiretroviral combination hiv ineligible positive immunodeficiency virus human therapy patients Cluster 78: reaction antibody monoclonal hypersensitivity severe history mab components infusion allergy Cluster 79: creatinine clearance gault cockcroft hour collection min ml urine formula Cluster 80: expectancy life weeks years predicted subject subjects minimum year patient Cluster 81: registration prior days weeks therapy chemotherapy patients radiation study biologic Cluster 82: anticoagulants therapeutic use dose current inr parenteral thrombolytic recent days Cluster 83: molecule therapy targeted small prior chemotherapy radiation weeks administered recovered Cluster 84: cooperation substance abuse disorders interfere requirements psychiatric trial known study Cluster 85: prednisone corticosteroids equivalent mg day doses dose systemic use chronic Cluster 86: composition compounds chemical similar attributed allergic reactions biologic history hypersensitivity Cluster 87: interstitial lung disease history signs symptoms ongoing time informed consent Cluster 88: woman childbearing pregnancy potential test negative wcbp serum hysterectomy prior Cluster 89: procedure surgical major anticipation need course study cycle day prior Cluster 90: heart class nyha york association new failure congestive ii chf Cluster 91: tissue paraffin embedded formalin fixed tumor available biopsy ffpe archival Cluster 92: cns metastases brain nervous central stable patients treated weeks disease Cluster 93: vaccine live received dose days study prior drug treatment medication Cluster 94: hemoglobin dl mg minimum patients enrollment phase weeks anemia arm Cluster 95: steroid systemic therapy concurrent intolerance immunosuppressive use known weeks physiologic Cluster 96: mutation flt ras testing tumor activating itd kras egfr patients Cluster 97: echocardiogram ejection fraction left ventricular lvef echo muga assessed radionuclide Cluster 98: pd checkpoint inhibitor immune ctla anti received inhibitors treatment prior Cluster 99: organ transplant allogeneic history major patients primary immunodeficiency having hematopoietic Cluster 100: adverse events grade related prior immune recovered therapy treatment event Cluster 101: diabetes mellitus diagnosis type glucose fasting insulin patients hypoglycemic current Cluster 102: pt time intended prothrombin anticoagulant anticoagulants inr normalized range ptt Cluster 103: investigational study participated therapy device participating currently agent used receiving Cluster 104: creatinine institutional normal levels clearance min ml upper limit patients Cluster 105: glioblastoma gliosarcoma histologically grade glioma confirmed iv multiforme world organization Cluster 106: tcl obtained cutaneous registration hepatosplenic angioimmunoblastic ul cm days panniculitis Cluster 107: cancer melanoma situ malignancy cervical skin non second carcinoma years Cluster 108: peripheral anc neutrophil absolute ul count marrow bone solid tumors Cluster 109: therapeutic trial clinical participation concurrent current treatment simultaneous trials enrollment Cluster 110: epidermal growth factor receptor egfr human positive prior therapy cancer Cluster 111: following criteria treatment satisfy cardiac patients diagnoses use combination patient Cluster 112: autoimmune vitiligo childhood resolved disease asthma atopy history atopic dermatitis Cluster 113: creatinine serum uln times institutional concentration days prior equal levels Cluster 114: severe disease uncontrolled systemic infection active concurrent morbidity current septicemia Cluster 115: subjects study therapy eligible investigator treatment prior receiving chemotherapy opinion Cluster 116: deems unsuitable candidate investigators opinion condition receive drug participant study Cluster 117: lactation pregnancy breastfeeding test positive current year women standards time Cluster 118: gfr renal glomerular filtration rate insufficiency min ml patients contrast Cluster 119: hormonal therapy prior cancer treatment months patients weeks chemotherapy study Cluster 120: comply willing able requirements protocol study procedures instructions subject follow Cluster 121: birth control methods method female use surgically sterile study male Cluster 122: aminotransferase times aspartate ast upper alanine normal alt limit serum Cluster 123: anc neutrophil absolute mm count peripheral randomization weeks cu days Cluster 124: total bilirubin mg dl serum days equal uln ml enrollment Cluster 125: asct patients stem relapsed post prior therapy eligible autologous refractory Cluster 126: uncontrolled unacceptable risks cause compromise safety severe concurrent compliance medical Cluster 127: likely interfere illness psychiatric participation medical clinical study patients opinion Cluster 128: phase inclusion criteria ii additional ecog expansion search specific bilirubin Cluster 129: vaccines influenza flu live allowed seasonal inactivated mist generally intranasal Cluster 130: neck head radiation prior therapy chemotherapy cancer previous region patients Cluster 131: understand able consent study informed written participate risks description benefits Cluster 132: study increase interpretation associated results participation interfere abnormality risk inappropriate Cluster 133: concurrent agents investigational receiving therapy biological use chemotherapy radiation patients Cluster 134: longer whichever lives half preceding investigational drug days dose study Cluster 135: hep hepatitis infection active hiv virus known immunodeficiency human positive Cluster 136: fungal bacterial viral infection clinically significant exhibits active uncontrolled systemic Cluster 137: oropharynx hpv squamous carcinoma cell associated positive proven biopsy nc Cluster 138: leukemia liver chronic fatty leukemias secretory burkitt accelerated inherited alcoholic Cluster 139: infectious interstitial pneumonitis lung non active evidence disease history known Cluster 140: seizures seizure disorder patients controlled history epilepsy febrile uncontrolled antiepileptic Cluster 141: pregnancy test negative serum female screening focbp days prior wocbp Cluster 142: brain metastasis symptomatic steroids patients uncontrolled requiring escalating doses metastases Cluster 143: relapsed refractory disease therapy patients prior line treatment aml cell Cluster 144: pembrolizumab nivolumab hypersensitivity prior dose treatment received therapy known mk Cluster 145: brain metastases treated weeks progression evidence mri imaging administration resonance Cluster 146: uln alkaline phosphatase involvement liver subjects limit cancer lymphoma direct Cluster 147: hipaa authorization health release information informed personal consent accountability portability Cluster 148: msi microsatellite instability mmr high mss dmmr mismatch msh repair Cluster 149: lesion measurable irradiated recist disease previously radiation cm mm index Cluster 150: alopecia grade excluding recovery prior recovered neuropathy effects adverse toxicity Cluster 151: care medical consent voluntary prejudice withdrawn future understanding procedure written Cluster 152: ecog performance status patients equal scale subject patient grade screening Cluster 153: targeted therapy chemotherapy prior treatment agents received immunotherapy including therapies Cluster 154: anesthesia general surgery requiring require scanning monitored major patients sedation Cluster 155: studies correlative tissue tumor consent future specimens blood patients provide Cluster 156: gm albumin dl serum plasma neratinib uln trametinib mg subjects Cluster 157: suspected autoimmune known active disease subjects participants patients exclusionary excluded Cluster 158: excipients hypersensitivity known drugs intolerance study allergies allergy ribociclib history Cluster 159: carcinoma malignancies cell situ basal cervix squamous skin years treated Cluster 160: lesions target measurable patients bone cm irradiated disease radiation tumor Cluster 161: daily equivalent mg prednisone dose corticosteroids chronic corticosteroid steroids doses Cluster 162: free disease years cancer malignancy unless history subject patient considered Cluster 163: mcl platelets cells cohort weeks phase randomization discretion transfusions plts Cluster 164: limits bilirubin total institutional normal gilberts upper registration cohort serum Cluster 165: bowel vomiting nausea inflammatory refractory resection gastrointestinal absorption diseases significant Cluster 166: gilbert bilirubin uln upper normal limit total syndrome unless disease Cluster 167: plan visits scheduled comply able laboratory tests willing treatment procedures Cluster 168: mds myelodysplastic syndrome diagnosis hypomethylating agent aml related treatment therapy Cluster 169: outpatient transluminal attack cerebrovascular transient ischemic vascular accident disease stent Cluster 170: pulmonary obstructive copd chronic disease severe lung asthma requiring oxygen Cluster 171: anti cancer therapy prior systemic treatment investigational weeks study days Cluster 172: heart york association new class myocardial infarction unstable failure congestive Cluster 173: pressure blood hypertension systolic controlled diastolic uncontrolled readings high adequately Cluster 174: dated signed informed consent written specific procedures study provision prior Cluster 175: beta chorionic gonadotropin hcg negative human test potential childbearing pregnancy Cluster 176: speaking english non spanish patients participants caregiver assessments person emr Cluster 177: values laboratory following adequate organ clinical function screening specified days Cluster 178: aspirin daily heparin prophylactic anticoagulation molecular weight mg asa low Cluster 179: csf gm filgrastim cytology sargramostim prior weeks erythropoietin lumbar patients Cluster 180: nci institute national neuropathy common ctcae grade terminology peripheral criteria Cluster 181: psa rising apart value ng week progression ml values prostate Cluster 182: source stem donor blood cell cells peripheral marrow hematopoietic unrelated Cluster 183: rcc advanced metastatic nephrectomy systemic prior therapy received treated radical Cluster 184: taking currently medications patients drugs medication study treatment immunosuppressive lithium Cluster 185: attacks accident cerebrovascular transient ischemic embolic past events months including Cluster 186: metastases carcinomatous brain meningitis cns nervous central treated participate previously Cluster 187: transplantation marrow bone history organ solid tuberculosis primary previous immunodeficiency Cluster 188: coagulopathy diathesis anticoagulation bleeding therapeutic absence evidence significant thromboembolic permitted Cluster 189: contraception dose preferred lifestyle usual abstinence therapy study method acceptable Cluster 190: small lung cell cancer non nsclc confirmed sclc carcinoma stage Cluster 191: intravenous antibiotics infection requiring active iv oral systemic uncontrolled registration Cluster 192: physiologic therapy consultation doses steroid sponsor immunosuppressive form corticosteroids approved Cluster 193: pneumonitis infectious steroids required non known history cohort current participants Cluster 194: donor cross match cytotoxic pra hla positive cytometric allele matches Cluster 195: abdominal perforation fistula gastrointestinal abscess intra history months prior ulcer Cluster 196: benefit standard therapy available clinical solid advanced convey metastatic histologically Cluster 197: trial confound best abnormality results interfere participate laboratory duration current Cluster 198: pancreatic previous cancer therapy chemotherapy radiation abdominal adenocarcinoma resection surgical Cluster 199: kps karnofsky performance status score greater patients equal patient ecog Cluster 200: donor selection identical nmdp pregnant eligibility cell recipient haploidentical chimerism Cluster 201: tablets swallow unable subject inability unwilling intact capsules patients absorb Cluster 202: oxygen saturation pulse oximetry rest resting hypoxemia baseline pao arterial Cluster 203: replacement systemic thyroxine pituitary insulin modifying physiologic adrenal insufficiency therapy Cluster 204: diffusion capacity monoxide carbon dlco predicted lung corrected pulmonary hemoglobin Cluster 205: carcinoma skin cell cancer situ basal curative cervical squamous potentially Cluster 206: aminotransferase alanine aspartate ast alt upper normal limit uln institutional Cluster 207: node lymph involvement dissection disease cm biopsy tumor patients regional Cluster 208: srs brain wbrt radiosurgery stereotactic lesions metastases patients radiation treated Cluster 209: progression disease evidence therapy documented prior treatment patients months study Cluster 210: unable consent informed cognitively patients written subjects subject study impaired Cluster 211: microliter leukocytes mcl fascial farber fap fanconi fancd fancc fanca Cluster 212: illness qt heart situations intercurrent congenital social arrhythmia compliance ongoing Cluster 213: compression carcinomatous meningitis spinal cord seizure brain metastases disorder active Cluster 214: bilirubin upper limit normal uln serum direct institutional equal institution Cluster 215: medication oral able swallow unable dissolving consume crushing chewing patient Cluster 216: investigational whichever half longer lives product agent prior days study Cluster 217: myeloma multiple criteria symptomatic standard according diagnosis diagnosed crab damage Cluster 218: detained involuntarily compulsorily prisoners incarcerated infectious illness psychiatric physical subjects Cluster 219: women unwilling childbearing contraception nursing men potential reproductive effective pregnant Cluster 220: zubrod performance registration status days prior step documented patients study Cluster 221: prevent signing abnormality condition illness psychiatric medical laboratory consent informed Cluster 222: healing fracture wound ulcer non bone presence untreated active nonhealing Cluster 223: metastatic cancer breast patients prior chemotherapy evidence disease received eligible Cluster 224: contraindications mri medical patients metallic nrt known claustrophobia use pancreatectomy Cluster 225: immunodeficiency acquired known testing virus syndrome human positive history hiv Cluster 226: expectancy life greater months equal physician morbid assessed treating determined Cluster 227: pregnancy childbearing negative test registration potential women days prior serum Cluster 228: lymphoma nervous central cns known leptomeningeal primary active history patients Cluster 229: follow willing study available required procedures patients completion permit circumstances Cluster 230: histological confirmation diagnosis breast cancer carcinoma metastatic required tumor patients Cluster 231: platelet count obtained registration days mm prior randomization mcl untransfused Cluster 232: past months history years year active sequelae event chemotherapy cerebrovascular Cluster 233: alk kinase anaplastic egfr receptor epidermal lymphoma growth factor mutations Cluster 234: biopsy bronchoscopic accessed percutaneous thoracoscopic safely perspective undergo willingness waived Cluster 235: older years old women men patients eighteen japan korea participants Cluster 236: subject study treatment protocol france investigator following french subjects condition Cluster 237: pregnancy wocbp minimized women manner using potential avoid products childbearing Cluster 238: arthritis rheumatoid lupus autoimmune disease erythematosus systemic sclerosis multiple inflammatory Cluster 239: finding metabolic reasonable suspicion contraindicates examination dysfunction physical render giving Cluster 240: cells platelet mm count marrow bone plasma nucleated plasmacytosis bil Cluster 241: irb approved sign document informed understand consent willing written able Cluster 242: vaccination attenuated receipt live days durvalumab entry receiving tremelimumab prior Cluster 243: pd anti agent received prior therapy treatment merck participated pembrolizumab Cluster 244: heart enrollment cerebral months accident stroke vascular cardiovascular arrhythmia infarction Cluster 245: obtaining existing disorder safety conditions interfere pre unstable compliance psychiatric Cluster 246: pugh child score class liver function hepatic disease points ascites Cluster 247: feeding breast pregnant patients patient currently subject subjects donor participant Cluster 248: epo dependency erythropoietin mmol transfusion assessment hemoglobin days dl initiation Cluster 249: breastfeeding pregnant women childbearing potential months intend plan currently study Cluster 250: alt ast uln liver serum times metastasis patients metastases bilirubin Cluster 251: cd anti antibody therapy prior treatment monoclonal previous directed received Cluster 252: recurrent disease metastatic patients progressive cancer refractory treatment received persistent Cluster 253: candidates patients surgical deemed considered surgery resection chemotherapy appropriate therapy Cluster 254: contrast mri gadolinium allergy contraindication enhanced iodinated ct intravenous agents Cluster 255: unknown nursing mother infants potential effects women pregnant teratogenic abortifacient Cluster 256: donors hla matched siblings unrelated donor related haploidentical allele drb Cluster 257: labs screening adequate performed organ days function demonstrate initiation treatment Cluster 258: therapy chemotherapy hormonal radiation cancer prior weeks treatment including immunotherapy Cluster 259: xrt radiation elapsed craniospinal irradiation substantial weeks local palliative pelvis Cluster 260: pregnant patients known included ineligible currently treated time enrollment study Cluster 261: stable corticosteroids dose decreasing days mri baseline prior patients steroids Cluster 262: method contraception barrier use effective childbearing potential willing discontinuation females Cluster 263: vascular peripheral disease collagen symptomatic significant clinically arterial patients active Cluster 264: normalized inr international ratio uln coagulation anticoagulation warfarin anticoagulants blood Cluster 265: gated muga acquisition multi echocardiogram fraction scan ejection cardiac echo Cluster 266: invasive carcinoma dcis breast ductal diagnosis situ cancer multicentric biopsy Cluster 267: promyelocytic leukemia acute diagnosis aml patients classification pml favorable cytogenetics Cluster 268: exclusion criteria tnbc cohort specific treatment patients patient phase screening Cluster 269: line therapy prior chemotherapy received disease patients treatment systemic second Cluster 270: bowel inflammatory disease history active gastrointestinal diarrhea patients chronic ongoing Cluster 271: pleural effusion clinically malignant significant ascites fluid chest ray pericardial Cluster 272: hematologic function adequate renal liver follows defined bm status coagulation Cluster 273: leukocytes mcl days registration phase obtained initiation ii treatment prior Cluster 274: hematocrit hct hemoglobin anemia donor dl reached days males transfusion Cluster 275: fish ihc hybridization situ fluorescence immunohistochemistry negative positive fluorescent breast Cluster 276: cytotoxic chemotherapy setting metastatic adjuvant prior lines neoadjuvant treatment therapy Cluster 277: hcv hepatitis hbv infection active viral virus chronic load known Cluster 278: corticosteroids permitted equivalents prednisone systemic mg autoimmune topical daily dye Cluster 279: gvhd host versus graft disease immunosuppressive active requiring therapy chronic Cluster 280: confirmed histologically cytologically diagnosis metastatic patients melanoma cancer pathologically carcinoma Cluster 281: blood products transfusion willing transfusions receive draw days donate patients Cluster 282: ethics nature board committee independent legal review representative procedure approved Cluster 283: rvo retinal csr hypercoagulability glaucoma hyperviscosity hypertension ocular history occlusion Cluster 284: schedule comply follow able visit unable treatment study willing plan Cluster 285: understand able provide consent written informed willing review patients starting Cluster 286: evaluations unable unwilling participate procedures required study judgment ibrutinib follow Cluster 287: requiring treatment active infection systemic malignancy acute psoriasis corneal assessments Cluster 288: pectoris angina infarction myocardial months unstable starting prior acute drug Cluster 289: immune mediated auto disease history therapy related prior suppressive suppression Cluster 290: malignancy cell recurrence deemed years basal free low carcinoma investigator Cluster 291: cancer cell basal situ squamous adequately skin treated years cervical Cluster 292: nsaids hypersensitivity sulfonamides nonsteroidal asa drugs celecoxib days antiinflammatory inflammatory Cluster 293: therapy prior systemic received chemotherapy patients treatment disease allowed radiation Cluster 294: mtor inhibitors inhibitor rapamycin prior treatment mammalian target received patients Cluster 295: protein dipstick urine urinary urinalysis routine hour hours mg collection Cluster 296: nursing female pregnant patients eligible participants subjects lactating intend study Cluster 297: creatinine mg dl equal renal cr umol level plasma norms Cluster 298: testosterone ng dl serum nmol level castration levels screening androgen Cluster 299: ventilation mechanical oxygen supplemental requiring saturation room air higher respiratory Cluster 300: bilirubin uln direct total gilberts normal syndrome upper limit serum Cluster 301: bmi index mass body patients scanner weight greater overweight bore Cluster 302: treated previously patients ixazomib therapy eligible prior subjects study chemotherapy Cluster 303: creatinine upper limit normal times institutional serum uln institution age Cluster 304: bilateral oophorectomy hysterectomy tubal ligation surgical salpingo sterilization salpingectomy prior Cluster 305: anticancer concurrent therapy investigational approved agents treatment therapeutic therapeutics steroids Cluster 306: gfr glomerular filtration rate min ml estimated creatinine calculated uln Cluster 307: condition compromise opinion situation protocol investigator aes underlying medical assessment Cluster 308: newly diagnosed cancer patients breast histologically stage disease untreated confirmed Cluster 309: dihydropyrimidine deficiency dehydrogenase dpd known fluorouracil fluoropyrimidine hypersensitivity capecitabine severe Cluster 310: sample tumor biopsy tissue archival available fresh provide archived testing Cluster 311: brain metastases known patients history active subjects presence patient treated Cluster 312: ul platelets cells days prior registration obtained treatment weeks enrollment Cluster 313: hepatitis reactive qualitative detected hbsag rna hcv ribonucleic surface acid Cluster 314: myeloma multiple diagnosis relapsed confirmed refractory therapy treatment prior patients Cluster 315: cytotoxic chemotherapy prior days therapy weeks treatment received previous cancer Cluster 316: astrocytoma anaplastic grade oligodendroglioma glioma glioblastoma oligoastrocytoma diagnosis iii gliomas Cluster 317: hiv immunodeficiency positive virus human patients excluded retroviral receiving anti Cluster 318: platelets mm cu weeks days day prior wbc study enrollment Cluster 319: diameter cm maximum lesion tumor longest lesions measurable largest maximal Cluster 320: cmv cytomegalovirus infection pcr retinitis active herpes viremia positive viral Cluster 321: equation creatinine gault cockcroft clearance min ml calculated estimated using Cluster 322: effective contraception use agree sterile patients surgically fertile study dose Cluster 323: pneumonitis history induced active ongoing drug years radiation confirmed patients Cluster 324: cypa grapefruit metabolized window predominantly narrow medications therapeutic hybrids star Cluster 325: vegf bevacizumab prior anti sunitinib sorafenib received inhibitor therapy pathway Cluster 326: bleeding hemorrhage event terminology ctcae common events adverse grade criteria Cluster 327: products investigational treatment dose drug study days therapy weeks allergic Cluster 328: intermediate dipss risk prognostic dynamic scoring international myelofibrosis high mf Cluster 329: illness situations pectoris social intercurrent compliance arrhythmia requirements psychiatric unstable Cluster 330: uncontrolled ischemia heart conduction electrocardiographic abnormalities arrhythmias ventricular class angina Cluster 331: grade ctcae common adverse toxicity terminology events criteria neuropathy alopecia Cluster 332: total bilirubin uln institutional age concentration institution days equal liver Cluster 333: safety interfere opinion investigator compromise illness evaluation drug condition dysfunction Cluster 334: hgb dl transfusion hemoglobin days blood allowed prior rbc criteria Cluster 335: involvement nervous central known lymphoma active leukemia myeloma patients history Cluster 336: nodal disease regional patients clinical evidence eligible involvement distant stage Cluster 337: hla donor antibodies anti antibody specific mfi recipient positive presence Cluster 338: pembrolizumab excipients hypersensitivity severe known grade epacadostat substance active history Cluster 339: expectancy life months predicted patients patient weeks subjects expected physician Cluster 340: alkaline phosphatase uln ast alt equal institutional days registration alk Cluster 341: confounds interpret data condition places ability study unacceptable abnormalities participate Cluster 342: msec qtc interval ecg prolongation screening baseline qt males females Cluster 343: major surgery recovered effects starting weeks prior study patient fully Cluster 344: enrollment prior study time weeks days patients months therapy treatment Cluster 345: toxic effects recovered fully entering acute prior chemotherapy immunotherapy radiotherapy Cluster 346: care standard patients therapy patient supportive treatment hospice clinic cancer Cluster 347: medication switched different qt discontinued interval treatment prolong torsades pointes Cluster 348: light chain protein free serum mg measurable dl urine ratio Cluster 349: hla typing resolution drb donor high unrelated matched allele dqb Cluster 350: personal history family syndrome qt long cancer crc melanoma participants Cluster 351: endotracheal endobronchial tumor evidence anus invading rectum esophagus cabozantinib tract Cluster 352: positive hiv known patients donor test hepatitis subject status excluded Cluster 353: pregnancy test positive urine period lactating screening day female serum Cluster 354: kinase inhibitor molecule small investigational treatment metabolites compound including receipt Cluster 355: history bilateral reproductive menopausal ligation menses tubal oophorectomy hysterectomy potential Cluster 356: heart uncontrolled failure congestive hypertension disease angina significant unstable symptomatic Cluster 357: oral medications ability swallow unable receive tolerate patients existing record Cluster 358: inducers strong inhibitors cytochrome cyp gp treatment cypc glycoprotein drugs Cluster 359: women pregnancy test childbearing negative potential serum days prior study Cluster 360: agent investigational days received enrollment prior use randomization treatment therapeutic Cluster 361: cardiovascular significant including disease clinically uncontrolled pulmonary poorly active condition Cluster 362: hemoptysis teaspoon weeks dose red drug blood excess ml bleeding Cluster 363: cabozantinib lln phosphorus dose potassium days calcium lower magnesium serum Cluster 364: ethnic groups races racial background eligible trial men women restrictions Cluster 365: poems syndrome plasma leukemia amyloidosis cell waldenstrom macroglobulinemia primary myeloma Cluster 366: provide unable consent informed unwilling patients written patient subjects adults Cluster 367: leptomeningeal disease manifestation history presence evidence patients diffuse spread untreated Cluster 368: vaccine live attenuated administration weeks study anticipation day cycle prior Cluster 369: infection active evidence systemic patients month responding pericardial past pulmonary Cluster 370: bevacizumab prior treatment patients therapy received weeks treated previously regimen Cluster 371: sarcoma soft tissue ewing rhabdomyosarcoma diagnosis tumor synovial kaposi gist Cluster 372: contraception methods oophorectomy hormone ovulation sterilization women case abstinence intrauterine Cluster 373: block degree av atrioventricular second nd rd ventricular ecg type Cluster 374: obtaining morbid inappropriate make judgment physicians informed consent patient clinician Cluster 375: mri ct scan disease measurable tumor imaging evidence days bone Cluster 376: enzyme inducing epileptic drugs eiaed antiepileptic phenobarbital phenytoin carbamazepine anti Cluster 377: toxicity grade alopecia therapy prior severity anti progressing ongoing cancer Cluster 378: situ carcinoma cervical cancer years skin basal malignancy melanoma cell Cluster 379: transaminase uln aspartate ast alanine alt upper normal limit liver Cluster 380: significant abnormalities clinically gastrointestinal urinalysis absorption disorders results affect relevant Cluster 381: board review irb approved institutional consent informed signed form written Cluster 382: steroids systemic inhaled requirement topical doses immunosuppressive corticosteroids drugs prior Cluster 383: feeding women breast pregnant currently study lactating excluded entered childbearing Cluster 384: surgically childbearing potential abstain heterosexual activity sterile sterilized study subjects Cluster 385: prostate cancer prior chemotherapy diagnosis therapy treatment resistant metastatic castration Cluster 386: investigational device drug study days treatment participation currently agent trial Cluster 387: severe bacteremia pneumonia hospitalization complications infection limited infections including weeks Cluster 388: spermicide contraception methods condom method male barrier plus diaphragm intrauterine Cluster 389: score karnofsky performance eastern cooperative oncology group ecog status lansky Cluster 390: study pregnant potential women contraception bearing inform immediately woman child Cluster 391: bearing child female pregnancy test potential negative serum urine patients Cluster 392: hiv antibodies immunodeficiency virus human known history testing required cohort Cluster 393: hsct allogeneic prior autologous undergoing patients transplant patient previous days Cluster 394: nodes lymph regional cm disease metastatic patients pelvic ct imaging Cluster 395: cns metastasis metastases nervous asymptomatic central treated steroids imaging previously Cluster 396: activity physical moderate engage minutes week intensity vigorous questionnaire sedentary Cluster 397: autoimmune disease history active deficiency diseases immune patients inactive documented Cluster 398: brca mutation deleterious germline cancer breast mutations known testing genes Cluster 399: platelet count ml days administration treatment study prior measured transfusions Cluster 400: pancreatitis history acute year chronic recent study entry past patients Cluster 401: ekg electrocardiogram qtc qt interval corrected significant msec clinically patients Cluster 402: stage iv cancer breast disease metastatic iii patients diagnosed diagnosis Cluster 403: ps eastern cooperative ecog oncology group performance status scale score Cluster 404: transfusions platelet blood red days platelets cell packed prior refractory Cluster 405: regimens cytotoxic chemotherapy prior metastatic received disease recurrent advanced systemic Cluster 406: radiographic evidence disease progression clinical metastatic documented cavitary necrotic measurable Cluster 407: gastrointestinal vomiting diarrhea nausea malabsorption ulcerative impairment disease absorption alter Cluster 408: form sign consent informed willing able understand specific written appropriately Cluster 409: grant inability compliance medical non consent history regimen patient regimens Cluster 410: creatinine upper limit normal uln serum institutional age equal registration Cluster 411: tyrosine kinase inhibitor inhibitors tki therapy prior treatment bruton egfr Cluster 412: myelodysplastic syndrome known leukemia presence history patients myeloproliferative neoplasm diagnosis Cluster 413: abiraterone enzalutamide acetate prior treatment ketoconazole tak ar therapy received Cluster 414: kidney function liver adequate bone marrow hematological disease stones solitary Cluster 415: subfamily cytochrome cypa family polypeptide strong inhibitors inducers medications substances Cluster 416: signs symptoms infection weeks cycle day prior treatment study active Cluster 417: impairment aged patient years known jeopardize mild hepatic renal moderate Cluster 418: advanced locally metastatic cancer breast unresectable incurable recurrent patients therapy Cluster 419: hbac glycosylated hemoglobin glucose diabetes measurement met poorly screening intolerance Cluster 420: pulmonary hypertension embolism disease severe significant history fibrosis cardiac patients Cluster 421: air saturation room oxygen baseline desaturation ambulatory rest function pulmonary Cluster 422: signed form consent informed icf study specific patient approved prior Cluster 423: geographical psychological permit familial sociological compliance protocol conditions follow unwillingness Cluster 424: pain scale score worst cancer patients opioid rating related nrs Cluster 425: cycle major surgery day days weeks prior recent diagnosis minor Cluster 426: hepatitis chronic infection active acute history known carrier viral hiv Cluster 427: histologically confirmed diagnosis cytologically cancer melanoma prostate breast disease hcc Cluster 428: vitamin warfarin antagonists anticoagulation equivalent requires phenprocoumon antagonist days require Cluster 429: hpv oropharyngeal papillomavirus positive status human vaccination pcr polymerase tumor Cluster 430: lymphocytic leukemia chronic cll lymphoma sll small diagnosis iwcll workshop Cluster 431: preclude participation investigator condition opinion medical study trial safe clinical Cluster 432: mab weeks earlier monoclonal administered antibody prior recovered adverse events Cluster 433: lipase normal upper limit serum institutional limits iuln pancreas institution Cluster 434: serous ovarian peritoneal fallopian grade high tube cancer endometrioid primary Cluster 435: tc clinical ajcc cancer th breast edition stage invasive joint Cluster 436: stratum dipg patients criteria inclusion progressed progressive recurrent non eligible Cluster 437: earlier weeks administered adverse events recovered agents entering radiotherapy chemotherapy Cluster 438: impair receive ability disorder medical uncontrolled protocol infection active subject Cluster 439: pd prior therapy treatment inhibitor anti ctla received patients pathway Cluster 440: intracranial hemorrhage stroke history months enrollment prior randomization significant registration Cluster 441: entire pregnancy unwilling avoid unable period acceptable wocbp method use Cluster 442: times upper normal limit alt liver ast uln transaminases igm Cluster 443: thromboplastin aptt activated partial time uln ptt institutional normal upper Cluster 444: ventricular atrial tested tachycardia degree old fibrillation block lvef arrhythmias Cluster 445: placement days subcutaneous access venous prior major device surgery enrollment Cluster 446: creatinine gault clearance cockcroft formula min calculated ml using uln Cluster 447: tomography ct computed pet emission positron measurable scan disease cm Cluster 448: hcc systemic diagnosis fibrolamellar prior mixed advanced therapy patients cholangiocarcinoma Cluster 449: limits corrected normal calcium albumin potassium magnesium serum supplements sodium Cluster 450: study pregnancy potential test negative childbearing contraception agree women use Cluster 451: clear rcc cell component histologically histology metastatic confirmed sarcomatoid advanced Cluster 452: absorption gastrointestinal affect condition interfere oral drug malabsorption medication significantly Cluster 453: evidence disease metastatic radiologic clinical definitive imaging patients time residual Cluster 454: anemia fanconi hemolytic aplastic marrow patients active syndromes sickle failure Cluster 455: investigational participated device agent participating currently using study weeks dose Cluster 456: identity ensure entered process order approval open board date network Cluster 457: thalidomide lenalidomide hypersensitivity known pomalidomide rash prior imids immunomodulatory applicable Cluster 458: blasts marrow bone blood peripheral leukemic aml circulating patients leukemia Cluster 459: criteria measurable response disease revised lymphoma iwg rano according malignant Cluster 460: specific signed informed consent procedures study prior written obtained initiation Cluster 461: creatinine clearance calculated uln crcl place institutional gfr glomerular filtration Cluster 462: count platelet hemoglobin neutrophil absolute dl anc function marrow bone Cluster 463: cytokine support count neutrophil absolute growth factor transfusion platelet mcl Cluster 464: home internet access computer address connection aim valid phase nursing Cluster 465: research samples purposes provide correlative blood willing tissue mandatory willingness Cluster 466: hiv immunodeficiency virus human known infection history patients testing diagnosis Cluster 467: mannitol hypersensitivity boron bortezomib azacitidine known suspected allergy velcade history Cluster 468: step registration prior crossover days patients treatment mcl optional dl Cluster 469: seropositive hiv immunodeficiency virus human known patients active infection eligible Cluster 470: lenalidomide prior therapy treatment use cycles patients dexamethasone received refractory Cluster 471: resection surgical patients tumor prior biopsy complete radiation weeks therapy Cluster 472: medications systemic mineralocorticoids immunosuppressant fludrocortisone azathioprine dose tnf orthostatic anti Cluster 473: cirrhosis hepatitis chronic liver active disease persistent steatohepatitis alcoholic evidence Cluster 474: malignancy history prior kind primary metastatic patients hematopoietic exception underlying Cluster 475: cells neutrophil absolute count mm anc days registration bil prior Cluster 476: invasive malignancy years prior history past cancer treated active treatment Cluster 477: psa prostate specific ng antigen ml days serum cancer value Cluster 478: ct chest abdomen pelvis scan tomography imaging computed mri contrast Cluster 479: gated muga acquisition echocardiogram lvef left fraction ejection ventricular scan Cluster 480: participant research study received encephalopathy does treatment cell deficits household Cluster 481: month participation study clinical product investigational involved preceding involving medication Cluster 482: condition medical investigator opinion participation study interfere psychiatric protocol compliance Cluster 483: anderson md center cancer mdacc patients care pa seen protocol Cluster 484: hepatitis virus hbv hcv infection active known chronic positive patients Cluster 485: grade examination neuropathy peripheral pain clinical period screening patient initiation Cluster 486: progressive disease rapidly patients evidence therapy time study months treatment Cluster 487: receive patients chemotherapy treatment unable planning study eligible therapy plan Cluster 488: recist measurable criteria disease according defined patients tumor lesion lesions Cluster 489: capsules swallow able inability patients unable bbi intact unwilling daily Cluster 490: blast cml crisis myeloid leukemia chronic phase myelogenous accelerated tyrosine Cluster 491: proteasome inhibitor immunomodulatory imid prior therapy bortezomib lenalidomide refractory lines Cluster 492: breast diagnosis cancer stage years confirmed current hr primary patients Cluster 493: highly effective contraception study use male female methods period potential Cluster 494: current use malignancy treatment history diagnosis study disease planned prior Cluster 495: clips metal aneurysm mri implants pacemakers metallic devices objects ferromagnetic Cluster 496: mg day prednisone equivalent kg steroid dose corticosteroid gvhd therapy Cluster 497: assent provide willing able written trial informed consent study participation Cluster 498: allergy known history intolerance patients hypersensitivity reaction products egg gadolinium Cluster 499: pediatric years patients age old children trials phase adult eligible Cluster 500: sexual latex contact condom vasectomy successful agree use potential men Cluster 501: renal insufficiency failure disease impairment kidney patients creatinine severe history Cluster 502: examinations visits including undergoing scheduled comply willing duration follow able Cluster 503: egfr tki treatment tm mutation erlotinib prior generation progression gefitinib Cluster 504: abstinence true contact heterosexual study interruption interruptions agree monthly commit Cluster 505: traumatic injury surgical procedure significant major days brain study prior Cluster 506: psychological substance abuse interfere social conditions study evaluation results participation Cluster 507: evaluable measurable disease patients subjects parts radiologically participants phase presence Cluster 508: medi small cohort lung cell cancer eligibility phase ii non Cluster 509: anti pd antibody pathways targeting specifically ctla checkpoint stimulation cell Cluster 510: wheelchair ambulatory paralysis walk score assessing age years lansky purpose Cluster 511: meningitis carcinomatous subjects known history brain presence leptomeningeal patients metastases Cluster 512: bisphosphonate denosumab therapy receiving treatment weeks hypercalcemia stable lack prior Cluster 513: rems program revlimid registered mandatory comply requirements mitigation willing able Cluster 514: fasting lipid lowering cholesterol triglycerides exceeded thresholds mmol included case Cluster 515: study agree barrier method course use accepted contraception dose drug Cluster 516: biopsy tumor accessible undergo patients amenable core biopsies treatment tissue Cluster 517: gm hemoglobin dl hgb transfusion creatinine days si equal prior Cluster 518: coagulopathy diathesis bleeding evidence history significant clinically inherited known risk Cluster 519: tissue excisional newly biopsy obtained core tumor archival sample lesion Cluster 520: resolved toxicities grade prior alopecia therapy related treatment neuropathy previous Cluster 521: opinion psychiatric investigator medical prevent interfere illness major completion illnesses Cluster 522: calculated creatinine clearance min ml measured serum uln days obtained Cluster 523: unable comply protocol requirements opinion investigator follow study patient consent Cluster 524: invading vessels encasing major blood tumor subject contact vessel abutting Cluster 525: talazoparib components hypersensitivity known capsule suspected bmn treatment previous prior Cluster 526: ps ecog performance status score subjects patient scale screening patients Cluster 527: organ function adequate defined follows protocol criteria following days baseline Cluster 528: coronary angioplasty stenting bypass acute myocardial infarction artery angina syndromes Cluster 529: score ecog performance status ipss scale subject patients symptom acceptable Cluster 530: amylase lipase uln serum normal institutional days registration prior limits Cluster 531: antineoplastic expected require form therapy localized systemic study patient protocol Cluster 532: spanish english speaks speaking reads consent able informed read french Cluster 533: radiotherapy weeks prior study dose treatment starting patients received palliative Cluster 534: breastfeeding discontinued excluded pregnant women participants mother lactating study treated Cluster 535: ct pet imaging mri diagnostic contrast patients fdg undergo scanning Cluster 536: procedures obtained informed consent written prior screening signed study specific Cluster 537: lymphoma follicular grade transformed fl indolent prior diagnosis treatment transformation Cluster 538: needle biopsy core fine aspiration fna breast diagnosis tumor invasive Cluster 539: protein polyneuropathy organomegaly endocrinopathy poems plasma changes dyscrasia monoclonal skin Cluster 540: half lives agents investigational prior days treatment therapy study drug Cluster 541: complying capable understanding protocol signed document informed consent requirements subject Cluster 542: site primary disease tumor patients radiation biopsy prior measurable unknown Cluster 543: bearing child women potential pregnant breastfeeding reliable means using contraception Cluster 544: lactating female pregnant patients subject subjects breastfeeding patient non male Cluster 545: carcinoma cell squamous adenocarcinoma histologically cancer confirmed adenosquamous nasopharyngeal patients Cluster 546: corticosteroids inhaled topical immunosuppressive systemic allowed steroids chronic treatment therapy Cluster 547: chimeric humanized fusion anaphylactic proteins antibodies reactions allergic hypersensitivity severe Cluster 548: transaminase glutamic serum pyruvic aminotransferase sgpt oxaloacetic sgot upper alt Cluster 549: recist based measurable disease determined site criteria presence radiology patients Cluster 550: hamster chinese ovary recombinant products antibodies hypersensitivity human cell known Cluster 551: uncontrolled myocardial infarction angina congestive heart failure months cardiac unstable Cluster 552: venous thrombosis thromboembolism arterial deep history embolism months pulmonary patients Cluster 553: fallopian tube peritoneal ovarian primary epithelial cancer carcinoma diagnosis histologic Cluster 554: grade tinnitus recovered note typical surgery hearing prior return qualify Cluster 555: tolerate inability able unable mri patients ascorbate oral position flexible Cluster 556: il interferon concomitant therapies regimens immunotherapy immunosuppressive non interleukin following Cluster 557: primary immunodeficiency history active secondary tuberculosis form subject known patients Cluster 558: induction chemotherapy aml therapy patients refractory intensive consolidation cr regimen Cluster 559: stage melanoma iv unresectable iii histologically confirmed metastatic diagnosis iiic Cluster 560: ascites paracentesis clinically encephalopathy significant hepatic trace moderate presence clinical Cluster 561: brentuximab vedotin prior treatment bv dose previous bendamustine hypersensitivity received Cluster 562: hypercalcemia uncontrolled symptomatic history bisphosphonate continued returns calcium patient requiring Cluster 563: bilirubin unless normal upper limit gilberts total involvement leukemic direct Cluster 564: diagnosis institutions kettering sloan mskcc memorial cancer epithelial sarcoma center Cluster 565: old age years donor patients greater time consent male equal Cluster 566: neutrophil absolute count ml days enrollment prior microliters randomization patient Cluster 567: elapsed weeks therapy prior days radiation chemotherapy completion minimum dose Cluster 568: virus hepatitis positive hcv immunodeficiency rna known hiv antigen ribonucleic Cluster 569: assessments complete follow able study baseline lack laboratory availability screening Cluster 570: cancer prostate skin malignancy situ melanoma non years cervical carcinoma Cluster 571: age male female years patients time consent subjects informed obtaining Cluster 572: diagnosed malignancy nonmelanoma residual type undergone resection situ skin carcinoma Cluster 573: assent parents representatives appropriate guidelines informed consent according authorized sign Cluster 574: ceritinib inclusion criteria prior dose capsules alk swallow gi therapy Cluster 575: ketoconazole itraconazole ritonavir clarithromycin telithromycin grapefruit voriconazole cypa inhibitors nelfinavir Cluster 576: cml phase chronic accelerated leukemia myeloid cp blast ph blasts Cluster 577: ul neutrophil absolute count cells days registration arm prior cohort Cluster 578: urethra ureter bladder pelvis transitional renal urothelial carcinoma cell histologically Cluster 579: hormone releasing lhrh luteinizing agonist orchiectomy antagonist androgen gnrh therapy Cluster 580: carcinomatous meningitis nervous metastases central cns known active untreated clinically Cluster 581: options treatment standard curative available informed patients exhausted therapy therapeutic Cluster 582: giving dementia understanding prohibit situations psychiatric social compliance illness requirements Cluster 583: attack accident cerebrovascular bypass transient coronary ischemic artery graft angina Cluster 584: understand ability informed consent provide willingness written nature signed study Cluster 585: exercise strenuous week intensity moderate minutes program vigorous able musculoskeletal Cluster 586: drug investigational weeks study preceding treatment prior start administration participation Cluster 587: analysis tissue tumor biomarker available biopsy results archived provide samples Cluster 588: live vaccine received days prior registration enrollment weeks treatment initiation Cluster 589: hypertensive encephalopathy crisis history prior hypertension controlled inadequately years mmhg Cluster 590: glioma grade high diagnosis recurrent low patients confirmed histologically iv Cluster 591: jak inhibitor janus kinase prior ruxolitinib therapy inhibitors treatment received Cluster 592: brachytherapy radiation prostate therapy external beam prostatectomy prior cryotherapy radical Cluster 593: irradiation prior pelvic brain body total tbi cranial craniospinal weeks Cluster 594: gsk chemically idiosyncrasy delayed immediate reaction drugs hypersensitivity related known Cluster 595: orally medication swallow unable likely absorption administered interfere disorders gastrointestinal Cluster 596: neuroendocrine cell small carcinoma histology cancer tumors prostate features acinar Cluster 597: beam external brachytherapy pelvic radiation radiotherapy prior received therapy prostate Cluster 598: hospitalization requiring registration exacerbation precluding coagulation respiratory obstructive transmural months Cluster 599: transplant autologous stem cell allogeneic prior months eligible patients study Cluster 600: contraception suppository film methods cream gel spermicidal foam vault cap Cluster 601: aptt intended anticoagulant ptt activated anticoagulants thromboplastin range pt partial Cluster 602: interpretation affect results malignancy compliance protocol second judgment history primary Cluster 603: caregiver patient primary identified family friend caregivers person willing parent Cluster 604: inhibitor prior treatment hsp therapy received hdac kinase previous met Cluster 605: colitis ulcerative crohns disease gastrointestinal inflammatory bowel history active chronic Cluster 606: valid consent informed able written willing provide benefits understanding nature Cluster 607: type diabetes mellitus ii insulin controlled patients hypothyroidism autoimmune uncontrolled Cluster 608: platinum resistant disease based refractory progression months therapy sensitive ovarian Cluster 609: final study administration period donate screening drug starting subject female Cluster 610: brain metastases stable treated asymptomatic patients weeks treatment eligible steroids Cluster 611: bowel affecting small stomach significantly malabsorption resection disease gastrointestinal obstruction Cluster 612: hepatic renal function adequate defined cardiac coagulation baseline pulmonary reference Cluster 613: therapy prior patients allowed radiation dose weeks days treatment chemotherapy Cluster 614: american asco society college pathologists cap guidelines receptor clinical er Cluster 615: ritonavir verapamil erythromycin inhibitors amprenavir ketoconazole cypa indinavir clarithromycin itraconazole Cluster 616: gog performance status patients grade gynecological oncology refer group appendix Cluster 617: monitoring safety comply opinion requirements able investigator study eligible patients Cluster 618: staff conduct planning astrazeneca applies study involvement site present previous Cluster 619: infection antibiotic requiring systemic days therapy study enrollment iv intravenous Cluster 620: venous access central catheter adequate apheresis leukapheresis peripheral donor line Cluster 621: portal vein main thrombosis invasion mesenteric smv superior encasement occlusion Cluster 622: females breastfeeding pregnant currently ineligible excluded childbearing current potential plan Cluster 623: trial trials included participation agents investigational duration clinical start days Cluster 624: ac hemoglobin hgb diabetes uncontrolled defined glycosylated hb poorly controlled Cluster 625: programmed death pd ligand cell prior protein lymphocyte cytotoxic anti Cluster 626: transformation aggressive richters cll lymphoma richter evidence fl hodgkin large Cluster 627: margins positive surgical negative margin excision tumor surgery lumpectomy mastectomy Cluster 628: receptor er estrogen progesterone pr positive negative breast epidermal growth Cluster 629: bp systolic deemed pressure controlled blood clinically investigator false familial Cluster 630: albumin dl days registration prior obtained serum study treatment mg Cluster 631: existing pre neuropathy grade peripheral greater conditions higher sensory patients Cluster 632: arrhythmic anti arrhythmias ventricular cardiac requiring therapy drugs fibrillation atrial Cluster 633: maximum creatinine age serum mg dl years male female gender Cluster 634: colony stimulating factor anc neutrophil count absolute granulocyte support csf Cluster 635: parp inhibitor treatment olaparib prior previous including inhibitors received patients Cluster 636: icf signing form time informed years age consent subject signed Cluster 637: return monitoring institution enrolling follow phase willing active study observation Cluster 638: prohibited medication currently taking listed treatments treatment receiving concomitant protocol Cluster 639: wbc white cells mm blood cell bil count weeks enrollment Cluster 640: autoimmune past years systemic required disease active treatment modifying immunosuppressive Cluster 641: virus hepatitis hcv hbv hiv immunodeficiency human infection known active Cluster 642: spermicide diaphragm condom uterine device abstinence birth acceptable control hormonal Cluster 643: curative treated prostate intent cancer situ carcinoma surgically negligible ductal Cluster 644: radiation therapy prior chemotherapy patients treatment days field gy allowed Cluster 645: currently investigational receiving drug eligible patients drugs excluded therapy participation Cluster 646: neurologic confound dysfunction evaluation brain develop prognosis adverse metastases events Cluster 647: flat lie pet tolerate unable ct scan scanner sub fit Cluster 648: vasectomized partner male sole azoospermia sterilization months confirmed female screening Cluster 649: uncontrolled diabetes hypertension days prior randomization assessment toxicity conditions interfere Cluster 650: abuse substance alcohol history psychiatric active disorders mental disorder alcoholism Cluster 651: malignancy concurrent active treatment presence patients patient actively skin years Cluster 652: weight kg body donor kilograms ideal kilogram lbs significantly patients Cluster 653: major surgery enrollment days weeks prior study month patients undergone Cluster 654: heart clinically significant history hypertension qt ecg labile cardiac msec Cluster 655: transplantation stem allogeneic cell hematopoietic prior undergone autologous patients history Cluster 656: karnofsky eastern cooperative performance oncology ecog group status kps lansky Cluster 657: disease inflammatory hashimoto bowel syndrome hypothyroidism autoimmune replacement following graves Cluster 658: previous treatment therapy exposure study chemotherapy assignment radiation months permanently Cluster 659: days growth acting factor elapsed events infusion adverse xrt therapy Cluster 660: mean ms ecgs electrocardiograms correction corrected qt qtc interval rate Cluster 661: bacterial fungal viral taking progression currently uncontrolled clinical medication symptoms Cluster 662: major surgery drug dose study weeks days prior administration trauma Cluster 663: clinical concerns safety contraindicate study procedures judgment participation condition compliance Cluster 664: expansion escalation dose ii enrollment participants biopsies syndrome history segment Cluster 665: albumin dl serum arm decreased cohort prothrombin range unless equal Cluster 666: metastatic disease patients known presence prior therapy patient systemic confirmed Cluster 667: spine mri lumbar vertebral patients brain osteoporosis prior hip surgery Cluster 668: specific study entry consent informed provide prior patient sign patients Cluster 669: blasts raeb anemia refractory excess mds myelodysplastic high leukemia risk Cluster 670: paracentesis requiring ascites thoracentesis effusions pleural days subjects prior randomization Cluster 671: creatinine uln institutional equal cohort baseline greater age biopsy plasma Cluster 672: undergone consecutive celibate orientation choice remaining months meets sexual regardless Cluster 673: constant antagonist pump proton antacids enzymes antagonists uses requirement pancreatic Cluster 674: pathology review confirmed diagnosis central report reviewed histologically center slides Cluster 675: interfere cooperate likely deemed ability participate condition mental investigator sign Cluster 676: hypersensitivity known history reaction patients ingredients products intolerance reactions comparator Cluster 677: fraction echocardiogram shortening ejection radionuclide angiogram gated muga study cardiac Cluster 678: cavity oropharynx larynx hypopharynx oral squamous carcinoma cell neck histologically Cluster 679: compression cord leptomeningeal spinal metastases brain disease cns carcinomatosis uncontrolled Cluster 680: qt syndrome long history family interval risk subject prolonged tdp Cluster 681: sgpt sgot uln alt ast liver metastases institutional present serum Cluster 682: provide able consent informed willing patients patient capable signed study Cluster 683: effective labeling practice mandated method agree uspi smpc time summary Cluster 684: reaction allergic history prior hypersensitivity involved known severe protocol drug Cluster 685: undergoing patients treatment cancer therapy chemotherapy surgery radiation laparotomy currently Cluster 686: receive cytotoxic regimen persistent management allowed recurrent required additional disease Cluster 687: leukoencephalopathy multifocal pml progressive history meningeal cerebral participants confirmed cunningham Cluster 688: understand able sign consent informed document willing patients read patient Cluster 689: childbearing potential female contraception non subjects use women females willing Cluster 690: antifungals antivirals antibiotics infection requiring active acute systemic prior parenteral Cluster 691: contraindication mri known medical ampicillin sulfamethoxazole prophylaxis hypersensitivity trimethoprim concomitant Cluster 692: protein urine ratio creatinine hour screening urinalysis gram mg proteinuria Cluster 693: iuln creatinine serum registration days prior clearance min levels cockcroft Cluster 694: participate study consent willing patients informed patient refuse willingness ability Cluster 695: steroidal inflammatory anti non aspirin drugs nsaids use agents nsaid Cluster 696: differentiated neuroendocrine poorly grade carcinoid tumor pancreatic tumors moderately carcinoma Cluster 697: ejection fraction cardiac echocardiogram radionuclide echo normal angiogram muga function Cluster 698: braf mek inhibitor kinase inhibitors prior mitogen therapy activated treatment Cluster 699: host versus graft transplantation allogeneic stem cell gvhd disease immunosuppressive Cluster 700: conjugated sum unconjugated age bilirubin upper limit normal uln total Cluster 701: alcohol drinks consumption excessive day use alcoholic oz wine ounces Cluster 702: inflammatory breast cancer tumors including women disease pagets evidenced assessment Cluster 703: fields overlap result region radiotherapy radiation prior therapy cancer study Cluster 704: ability consent informed willingness donor patients lack demonstrate precludes likely Cluster 705: voluntarily understand ability informed consent sign form document willingness fanca Cluster 706: cellulose microcrystalline stearate colloidal silicon magnesium dioxide crospovidone mannitol excipients Cluster 707: cytological histological diagnosis metastatic confirmation adenocarcinoma evidence cancer advanced prostate Cluster 708: phq questionnaire score suicidal mood ideation health patient question thoughts Cluster 709: gestation termination conception state hcg nursing lactating laboratory female pregnancy Cluster 710: medications able oral orally patients patient tube feeding willing retain Cluster 711: pelvic radiotherapy prior previous patients surgery chemotherapy history received rt Cluster 712: score eastern cooperative group oncology performance ecog status subjects patients Cluster 713: fgfr inhibitor selective fgf prior receipt treatment amplification alterations tumor Cluster 714: growth factor support transfusion days independent hemoglobin hematopoietic platelets dl Cluster 715: phase ii patients randomized disease portion prior trial measurable ecog Cluster 716: condom intercourse drug males father sexually vasectomized stopping taking child Cluster 717: threatening maintenance arrhythmias ventricular infarction myocardial ongoing life congestive heart Cluster 718: myelosuppressive nitrosourea chemotherapy weeks received prior days study enrollment dose Cluster 719: cavitating lesion radiographic pulmonary evidence subject centrally vessel nsclc abutting Cluster 720: transplant organ solid allogeneic stem cell tissue prior marrow bone Cluster 721: aml mds patients prior cmml therapy blasts leukemia secondary relapsed Cluster 722: gpd phosphate deficiency dehydrogenase glucose known history patients hereditary normal Cluster 723: taxane chemotherapy prior anthracycline based received therapy regimen platinum metastatic Cluster 724: dr donor matched hla unrelated loci allele dq antigen related Cluster 725: test urine pregnancy negative serum female confirmed days potential positive Cluster 726: prohibitions restrictions adhere specified willing protocol able schedule visit study Cluster 727: immunodeficiency aids known acquired syndrome hiv virus human testing positive Cluster 728: injections articular intranasal inhaled topical intra local injection steroid medication Cluster 729: transaminase aminotransferase serum uln pyruvate glutamic glutamate oxaloacetic sgot sgpt Cluster 730: hematologic visit factors growth screening values laboratory days obtained transfusions Cluster 731: slides unstained tissue tumor block available paraffin archival availability biopsy Cluster 732: renal function marrow bone adequate hepatic liver cardiac coagulation metabolic Cluster 733: pacemaker defibrillator implantable cardiac mri cardioverter clip contraindication presence aneurysm Cluster 734: influenza attenuated vaccine live season october march vaccination cycle approximately Cluster 735: palbociclib ribociclib cdk possible hypersensitivity fulvestrant endocrine excipients abemaciclib previous Cluster 736: inclusion criteria registration specific screening treatment patients arm cohort patient Cluster 737: pet scan ct fdg bone imaging disease weeks mri patients Cluster 738: glucose fasting mg dl diabetes blood serum mellitus uncontrolled random Cluster 739: myelomonocytic cmml leukemia chronic mds juvenile myeloproliferative mpn myelodysplastic diagnosis Cluster 740: transplantation stem autologous cell hematopoietic patients eligible prior high chemotherapy Cluster 741: macroglobulinemia waldenstrom waldenstroms courses failed workshop clinicopathological immunoglobulin igm myeloma Cluster 742: remission complete cr leukemia relapse risk high induction patients disease Cluster 743: archival tissue tumor available biopsy fresh provide undergo willing sample Cluster 744: hepatitis surface antigen positive known infection suspected active rna virus Cluster 745: toxic grade effects resolution alopecia acute prior therapy resolved neuropathy Cluster 746: standard therapy progressed exists advanced intolerant solid metastatic tumors patients Cluster 747: ecg electrocardiogram clinically significant lead abnormal investigator abnormalities findings screening Cluster 748: lines therapy prior received systemic advanced disease chemotherapy treatment number Cluster 749: lymphocyte count absolute ul mm registration days cells obtained study Cluster 750: female reproductive employing birth control feeding effective pregnant breast potential Cluster 751: treatments agents concurrent anti use cancer experimental investigational study days Cluster 752: gi tolerance swallowing difficulty absorption procedure interfere gastrointestinal oral ixazomib Cluster 753: tsh thyroid stimulating hormone normal limits free wnl thyroxine euthyroid Cluster 754: transplantation stem organ allogeneic cell solid prior including history transplant Cluster 755: gene therapy prior product idh modified mutation amplification treatment tumor Cluster 756: federal accordance guidelines institutional written informed consent local signed provide Cluster 757: consciousness loss attack transient ischemic months history unexplained enrollment subject Cluster 758: authorized legally irb representative board applicable review document approved understand Cluster 759: pregnancy current known female patient active exclusion patients required test Cluster 760: target designated irradiated field persistence lesions confirm tumors assess progression Cluster 761: heparin fondaparinux lmwh warfarin molecular weight derived coumarin low prophylaxis Cluster 762: globulin atg thymocyte anti antithymocyte campath alemtuzumab received days cell Cluster 763: involvement marrow lymphoma platelets bone unless documented mcl platelet mm Cluster 764: unsuitable makes opinion condition subject participation investigator trial investigators make Cluster 765: hematologic end organ function adequate days study treatment initiation obtained Cluster 766: untreated nervous central metastases cns active symptomatic brain known progressing Cluster 767: interpretation results safety interfere evaluation condition opinion study investigator patient Cluster 768: cancers invasive years malignancy skin non cancer melanoma situ history Cluster 769: parenteral nutrition obstruction routine requirement tube signs symptoms gi hydration Cluster 770: epic questionnaire complete composite expanded willingness ability index prostate domains Cluster 771: lymphoma cell mantle leukemia nk large patients primary cutaneous ptcl Cluster 772: compliance regimens unreliable non medical entire history potentially complete considered Cluster 773: leukemia cns nervous central active known patients clinically evidence clinical Cluster 774: bilateral breast orchiectomy synchronous cancer patients mastectomy unilateral cancers eligible Cluster 775: gbm recurrent histologically glioblastoma recurrence confirmed proven diagnosis gliosarcoma treatment Cluster 776: sign willingness understand ability written informed consent subjects registration patients Cluster 777: uln aminotransferase bilirubin alt ast aspartate alanine normal upper limit Cluster 778: time practice effective agree methods childbearing contraception signing potential informed Cluster 779: discontinued prior therapy weeks days treatment biologic study registration radiation Cluster 780: cancer cervix situ melanoma carcinoma skin non years malignancy remission Cluster 781: liver function disease patients metastases tests tumor lfts burden volume Cluster 782: agonist ctla ipilimumab prior inhibitor lymphocyte cd cytotoxic treatment history Cluster 783: start treatment prior weeks study days therapy chemotherapy radiation investigational Cluster 784: age years lansky karnofsky performance status patients scale children ecog Cluster 785: investigational agent weeks treatment study prior dose administration therapy initiation Cluster 786: ggt gamma glutamyl transpeptidase uln alkaline phosphatase transferase lactate ldh Cluster 787: breast cancer mammogram imaging biopsy erythema surgery suspicious radiation patients Cluster 788: protein urine mg hour reactive hr urinalysis monoclonal mgps albumin Cluster 789: schizophrenia disorder bipolar major depression psychiatric depressive ideation mental psychosis Cluster 790: version recist measurable disease according lesion defined criteria site patients Cluster 791: toxicity recovered prior therapy grade patients previous acute treatment days Cluster 792: enrolled protocol subjects female intensification subject point treatment radiation completed Cluster 793: sign consent informed patients able willing written refusal document patient Cluster 794: organ function marrow bone adequate defined days laboratory registration patients Cluster 795: pancreatic adenocarcinoma histologically confirmed cytologically metastatic ductal advanced diagnosis patients Cluster 796: hematologic malignancy malignancies non acceptable patients oncologic relapse transplant status Cluster 797: bilirubin total gilbert mg dl syndrome uln subjects patients serum Cluster 798: physical exam mental imaging examination disease cm limitations study findings Cluster 799: exon egfr mutation lr insertion deletion mutations activating gx lq Cluster 800: agents receiving participants study patients concurrently currently treatment weeks prior Cluster 801: permitting release personal authorization information health approved signed informed consent Cluster 802: opportunistic infections concurrent infection dosing cmv day previous viral active Cluster 803: allograft organ transplantation history prior allogeneic immunosuppression transplant transplanted marrow Cluster 804: gross resection total hematuria tumor disease residual hemoptysis patients subtotal Cluster 805: aminotransferase uln involvement alt ast alanine aspartate liver cancer subjects Cluster 806: thromboembolic event history months arterial events venous past hemorrhagic anticoagulation Cluster 807: neoplasm agent considered primary investigational receiving treatment registration currently prior Cluster 808: tamoxifen aromatase raloxifene inhibitors therapy estrogen selective breast receptor cancer Cluster 809: fever infection active unexplained celsius hours scheduled degrees day enrollment Cluster 810: illicit user abuse regular recreational alcohol drugs substance recent including Cluster 811: mellitus diabetes insulin poorly controlled induced dependent steroid history hbac Cluster 812: quit smoking date trying attempt users interested willing set current Cluster 813: thrombosis deep vein embolism pulmonary dvt history pe months venous Cluster 814: use prior medications days chronic study intermittent day allowed patients Cluster 815: glucose mellitus diabetes closely antidiabetic dm monitored adjusted hbac necessary Cluster 816: inhibitors reductase prior alpha monoamine oxidase treatment use therapy finasteride Cluster 817: rvo retinal occlusion vein history current evidence risk factors patients Cluster 818: signed consent informed given study document patients approved registration prior Cluster 819: locally recurrent metastatic disease breast cancer advanced prior therapy inoperable Cluster 820: potassium limits normal meq serum range institutional institution wnl supplementation Cluster 821: sufficient involved field days interval small radiotherapy considered administration ixazomib Cluster 822: infectious pneumonitis non evidence active known history patient process steroids Cluster 823: ul anc neutrophil absolute count cells days registration prior neutropenia Cluster 824: visceral disease crisis threatening metastases metastasis life rapid liver severe Cluster 825: reproductive contraception potential effective use agree female study method male Cluster 826: alanine aminotransferase alt uln hepatic laboratory days iu involvement unless Cluster 827: willing written able provide informed consent trial patient subject participate Cluster 828: undergone consecutive bearing child woman potential pregnant celibate study remaining Cluster 829: warfarin low heparin thrombin lmwh inhibitors xa dose therapeutic molecular Cluster 830: muscular myopathies dystrophy neuromuscular amyotrophic atrophy lateral ck sclerosis spinal Cluster 831: aminotransferase aspartate alanine ast alt uln institutional normal unless serum Cluster 832: gemcitabine paclitaxel nab cisplatin prior hypersensitivity treatment received chemotherapy patients Cluster 833: setting metastatic prior therapy received adjuvant chemotherapy regimens line lines Cluster 834: survival expected months days weeks free greater infection time opinion Cluster 835: granulocyte count mm absolute ul agc peripheral starting days platelets Cluster 836: heart congestive failure symptomatic history chf disease active requiring arrhythmia Cluster 837: completed prior therapy weeks radiation chemotherapy enrollment radiotherapy study treatment Cluster 838: infarction myocardial months history prior mi past study registration acute Cluster 839: patients disease study prior treatment months defined known score days Cluster 840: neutrophil mm absolute count greater cu days neutrophils hemoglobin inclusion Cluster 841: hepatitis hiv immunodeficiency virus human known positive active history serology Cluster 842: dlco predicted pulmonary fev fvc corrected function oxygen pfts saturation Cluster 843: hemoglobin registration dl obtained days prior mg creatinine step study Cluster 844: anticoagulation therapeutic applies inr aptt normalized ratio thromboplastin activated international Cluster 845: hampering sociological potentially familial psychological schedule compliance condition follow study Cluster 846: cancer adequately treated remission cell complete stage currently patient basal Cluster 847: phosphorus lln lower serum normal limit calcium potassium magnesium supplementation Cluster 848: bilirubin uln gilbert level enrolled total serum known upper limit Cluster 849: hours pregnancy test negative potential childbearing serum women urine study Cluster 850: ipss mds intermediate prognostic scoring risk high international revised int Cluster 851: component hypersensitivity known formulation allergy bevacizumab study reaction history drug Cluster 852: cancer diagnosis active history years patients prior evidence previous skin Cluster 853: breastfeeding subject pregnant female healthy intends enrolling days study fancc Cluster 854: resonance magnetic imaging mri contrast brain mr undergo patients contraindication Cluster 855: leukocytes ul secondary days treatment obtained radiotherapy prior cells performed Cluster 856: unequivocal metastatic radiologic cytologic pathologic disease physical examination invasive metastasis Cluster 857: hepatitis antibody antigen test hcv positive negative hbsag infection hbc Cluster 858: menopausal sterilization bearing post child beta hcg potential surgical previous Cluster 859: various analogues formulations excipients allergy medications agent known study allergic Cluster 860: amylase uln serum normal upper limit pancreatic institutional pancreatitis grade Cluster 861: legally authorized representative consent informed written provide patient sign understand Cluster 862: msec qtcf fridericia qt interval formula corrected using correction ecg Cluster 863: expectancy life eastern cooperative ecog group oncology performance status months Cluster 864: calcium ionized serum albumin normal corrected lln total limits supplementation Cluster 865: congenital qt long syndrome history diagnosed family suspected sudden patients Cluster 866: seropositivity hiv immunodeficiency virus human known history infection hepatitis patients Cluster 867: visits ability scheduled understand document tests willingness plans comply informed Cluster 868: treated adequately disease evidence felt malignancy recurrence intent lentigo low Cluster 869: federal informed accordance nature guidelines given written consent institutional investigational Cluster 870: heart association iii york class iv new disease cardiac nyha Cluster 871: glomerular filtration rate creatinine min ml gfr mg dl serum Cluster 872: breastfeeding pregnancy current active women reported self planning possibility intention Cluster 873: distant metastases evidence metastatic disease patients documented regional presence clinical Cluster 874: time aptt thromboplastin activated partial inr normalized ratio prothrombin international Cluster 875: intra thoracic surgery abdominal injury pelvic major starting procedure effects Cluster 876: effective contraception childbearing potential use highly study dose agree months Cluster 877: disorder bleeding unrelated significant congenital acquired cancer history cml presence Cluster 878: excipient durvalumab hypersensitivity history tremelimumab medi known sgi substance component Cluster 879: utilize condom partner sexually birth concluded methods effective control willing Cluster 880: provision existing safety pre interfere unstable condition psychiatric medical consent Cluster 881: fda food met nci institute national studies administration institutional human Cluster 882: urine proteinuria hour protein collection dipstick urinalysis undergo quantitative hours Cluster 883: pregnancy potential women childbearing study importance wocbp advised avoiding test Cluster 884: kg weigh cd cells minimum stem patients cell weighing apheresis Cluster 885: performed written related provide obtained procedures informed consent participation ability Cluster 886: creatinine clearance min ml estimated serum uln renal cc measured Cluster 887: vaccines live attenuated typhoid rubella mumps yellow measles influenza bcg Cluster 888: bleeding acquired disorder diagnosed viii von disorders congenital willebrands unrelated Cluster 889: aphasia paresis brain cerebellar psychosis injuries epilepsy dementia organic cns Cluster 890: prison residing patients zydelig families fap fanconi fancd fancc fanca Cluster 891: pheochromocytoma patients concurrent diagnosis metastatic regorafenib biochemically phases untreated hyper Cluster 892: seizures history past prior controlled epileptic encephalitis patients movement disorders Cluster 893: transplant liver post prior days patients months eligible history time Cluster 894: recist measurable defined disease lesion patients ct imaging non presence Cluster 895: institutional aminotransferase ast aspartate upper normal limit times uln days Cluster 896: hepatitis ml copies viremic iu dna deoxyribonucleic carrier virus active Cluster 897: criteria response recist solid evaluation tumors measurable disease lesion evaluable Cluster 898: higher neuropathy grade peripheral patients ctcae neurotoxicity current ii arm Cluster 899: gastrointestinal alter impairment absorption function significantly incidence disease metabolism rapamycin Cluster 900: institutional bilirubin upper total uln normal limit level days registration Cluster 901: mothers nursing pregnant women excluded breastfeeding bearing study child eligible Cluster 902: diffusing monoxide carbon dlco capacity predicted corrected lung hemoglobin lungs Cluster 903: inactivated vaccines vaccination avelumab prohibited administration weeks dose trial influenza Cluster 904: abdominal cavity radiotherapy prior radiation pelvis portion patients received outside Cluster 905: nursing lactating pregnant women pdr plan discontinued breastfeeding bearing child Cluster 906: effects toxic terminology common grade ctcae institute resolution national adverse Cluster 907: estimated expectancy life weeks investigator judgment years participant permit greater Cluster 908: factors growth hematopoietic days transfusions prior treatment erythropoietin therapy platelet Cluster 909: curatively treated cancer years situ skin melanoma adequately solid evidence Cluster 910: immunodeficiency combined form primary severe disease acquired aids deficiency syndrome Cluster 911: methods ovulation abstinence contraception periodic symptothermal calendar withdrawal acceptable lifestyle Cluster 912: platelet independent transfusion count transfusions mm ul receiving defined enrollment Cluster 913: tuberculosis active history known latent hepatitis infection years preceding patients Cluster 914: exist longer measures curative standard effective palliative unresectable histologically confirmed Cluster 915: agents investigational weeks use study treatment days prior current receiving Cluster 916: er pr positive breast cancer negative ihc staining receptor pgr Cluster 917: increase risk medical toxicity opinion condition investigator patients potentially illness Cluster 918: menopausal post pre pregnancy women test negative peri serum status Cluster 919: bleeding ulcer peptic active diathesis uncontrolled epistaxis disease patients spontaneous Cluster 920: resected completely malignancy successfully history free skin years carcinoma melanoma Cluster 921: hemoglobin dl hgb achieve transfusion intervention acceptable note use registration Cluster 922: creatinine clearance gault cockcroft min ml calculated mg dl formula Cluster 923: agree abstain intercourse heterosexual practice time contraception completely signing effective Cluster 924: equivalents prednisone daily mg corticosteroids immunosuppressive medications inhaled systemic adrenal Cluster 925: bilateral potential females childbearing postmenopausal surgically hysterectomy oophorectomy sterile tubal Cluster 926: undergone surgery major prior patients weeks debulking hours subjects days Cluster 927: limits creatinine normal institutional upper serum uln times troponin days Cluster 928: uln liver ast alt metastases bilirubin function hepatic transaminases total Cluster 929: seronegative antibody hiv immunodeficiency human virus depends donor treatment intact Cluster 930: contraception use adequate method agree study male duration willing agrees Cluster 931: spanish speak english read able patients inability understand caregiver phase Cluster 932: asthma mild history severe persistent chronic moderate requiring inhaled currently Cluster 933: nsclc histologically cytologically confirmed stage iv squamous iiib diagnosis non Cluster 934: hematological renal adequate hepatic function coagulation liver assessments laboratory metabolic Cluster 935: melanomatous invasive malignancy free skin non cancer years unless minimum Cluster 936: hypertension uncontrolled controlled mmhg patients poorly medication history pressure severe Cluster 937: doxorubicin cumulative mg epirubicin dose anthracycline exposure anthracyclines equivalent prior Cluster 938: directed discontinued therapy tumor malignant prior immunologic registration hormonal agents Cluster 939: transfusion hemoglobin dl support allowed independent days factors growth prior Cluster 940: practice abstinence methods agree ovulation true contraception lifestyle usual symptothermal Cluster 941: breastfeeding pregnancy test negative pregnant entry days study childbearing women Cluster 942: obscure hazardous condition interpretation make underlying opinion frequent events adverse Cluster 943: patients disease men zydelig fanca fascia farber fap fanconi fancd Cluster 944: potentially completion interfere illness psychiatric according opinion medical investigators protocol Cluster 945: anti ctla adverse pd effects immune weeks dose ctcae met Cluster 946: glutamic oxaloacetic sgot transaminase serum normal upper limit times uln Cluster 947: mmol hemoglobin dl days initiation performed treatment transfusion registration assessment Cluster 948: greater hemoglobin dl equal gm screening values visit transfusion level Cluster 949: nodal lesions mm axis recorded short accurately longest dimension calipers Cluster 950: tuberculosis previous diagnosis clinical known history ppd purified eligibility phase Cluster 951: cns metastases nervous central symptomatic untreated neurologically patients known primary Cluster 952: nursing pregnant patient females entry physiologically previous female time capable Cluster 953: apply protocol defined exclusion criteria inclusion pregnant nursing lactating details Cluster 954: metabolism outcomes dysfunction threatening absorption undue compromise safety organ interfere Cluster 955: malabsorption stomach bowel absorption resection small syndrome gastrointestinal major affect Cluster 956: time prothrombin pt ptt thromboplastin partial normal uln upper limit Cluster 957: times bilirubin total upper limit normal uln institutional gilberts serum Cluster 958: components allergy history drug study known hypersensitivity nivolumab treatment reaction Cluster 959: bowel disease celiac colitis diarrhea gastrointestinal inflammatory irritable chronic associated Cluster 960: nervous central metastases cns known brain active history treated presence Cluster 961: institutional bilirubin upper normal limit total age direct registration serum Cluster 962: expectancy life greater weeks equal year years patients month inclusion Cluster 963: cyclodextrin captisol solubilize derivative carfilzomib allergy used known history bendamustine Cluster 964: participants research study prior eligible treated treatment received malignancy therapy Cluster 965: pressure blood sbp mmhg dbp systolic diastolic hypertension antihypertensive adjustment Cluster 966: giving consent capable informed written psychiatric patient debilitating medical illness Cluster 967: weeks therapy prior chemotherapy treatment nitrosourea dose cytotoxic mitomycin radiation Cluster 968: hyperbilirubinemia benign bilirubin total congenital uln unless serum hereditary syndrome Cluster 969: metastases brain evidence enlarging returned trial neurologic imaging symptoms meningitis Cluster 970: creatinine institutional normal limits clearance min levels ml patients gault Cluster 971: urea nitrogen bun blood mg dl normal times upper limit Cluster 972: privacy protected regulations dated authorization purpose accordance information risks national Cluster 973: weeks mitomycin nitrosoureas earlier entering administered adverse events recovered agents Cluster 974: phosphatase alkaline times upper normal limit liver unless limits phos Cluster 975: viral hepatitis bacterial fungal infection hiv immunodeficiency virus human active Cluster 976: aged years patients child parents men women children consent time Cluster 977: mother discontinued breastfeeding agent study excluded pregnant women treated discontinuation Cluster 978: nursing pregnant females patients subjects non potential harm infants study Cluster 979: causes dyspnea effusion ascites pleural respiratory compromise grade ctcae version Cluster 980: transaminase aminotransferase serum pyruvate glutamic glutamate oxaloacetic sgot sgpt aspartate Cluster 981: function cardiac adequate assessed physical normal examination pulmonary history clinically Cluster 982: chorionic hcg gonadotropin beta human pregnant women positive serum test Cluster 983: proteinuria grade urinalysis ctcae greater hrs hematuria hours persistent gm Cluster 984: radical prostatectomy prostate cystectomy cryosurgery cancer undergo scheduled adenocarcinoma patients Cluster 985: ppi pump proton inhibitor daily taken receiving dose study use Cluster 986: qt prolongation interval risk long qtc syndrome arrhythmic heart factors Cluster 987: potency manifestations psoriasis hydrocortisone arthritis autoimmune patients lichen oral chronicus Cluster 988: bearing child pregnancy test negative potential women serum urine days Cluster 989: mg dl years age creatinine male female serum gender gfr Cluster 990: unwilling comply unable eligible protocol patients swallow oral medication requirements Cluster 991: carcinoma skin cell progressing potentially requires exceptions additional curative basal Cluster 992: seizure history disorders predispose patients anticonvulsant activity months condition disorder Cluster 993: radiation recovered note nilotinib registration aside imatinib dasatinib qualify weeks Cluster 994: obstruction bowel biliary signs stent intestinal history symptoms evidence partial Cluster 995: hla positive allele patients expression phenotype express subject central restriction Cluster 996: triple negative breast cancer cohort tnbc metastatic confirmed histologically advanced Cluster 997: hemo dialysis peritoneal renal failure requiring hematological fap fanconi fancd Cluster 998: applications sprays drops eye injections airways rash topical inhaled articular Cluster 999: heart york association failure new congestive class ii iv symptomatic Cluster 1000: illness condition medical abnormality laboratory psychiatric prevent participating significant subject Cluster 1001: lobular carcinoma situ breast lcis ductal cancer dcis invasive hyperplasia Cluster 1002: autoimmune requiring trigger recur hypothyroidism vitiligo mellitus psoriasis replacement diabetes Cluster 1003: aware nature indicating informed sign consent investigational study patients risks Cluster 1004: bronchial palliation occlusion bleeding major amenable receives preparative elapsed cohort Cluster 1005: intravenous bacterial fungal antibiotics acute requiring infection time registration active Cluster 1006: vaccine prevention infectious therapy non oncology diseases administration ipilimumab dose Cluster 1007: angioplasty stenting cardiac heart infarction myocardial angina unstable vascular cardiovascular Cluster 1008: document sign understand written consent willing informed able patient patients Cluster 1009: disorders absorption gastrointestinal interfere extensive drug study surgery medical history Cluster 1010: pills swallow able ability patients unable impairs patient condition mouth Cluster 1011: past years psoriasis vitiligo disease autoimmune graves requiring systemic documented Cluster 1012: field wide radiation palliation radiotherapy weeks limited therapy effects study Cluster 1013: corticosteroids exceed intranasal physiological inhaled prednisone equivalent doses immunosuppressive corticosteroid Cluster 1014: antiviral infection chronic hepatitis requiring active therapy current hiv immunodeficiency Cluster 1015: status performance ecog karnofsky appendix occasional help care patients able Cluster 1016: breastfeed infants lactating females agreed plan unless eligible study female Cluster 1017: creatinine range serum normal min ml clearance outside renal reference Cluster 1018: thyroid cancer replacement patients hypothyroidism medullary papillary anaplastic hormone disease Cluster 1019: providing capable consent informed procedures written complying patient parent guardian Cluster 1020: breastfeeding pregnant patients intending currently participants wocbp participant donor study Cluster 1021: alcohol abuse current drug dependence illicit psychiatric known evidence drugs Cluster 1022: alp alkaline phosphatase uln liver metastases bone ulrr aminotransferase ast Cluster 1023: fvc vital forced capacity predicted corrected pulmonary hemoglobin expected value Cluster 1024: places unacceptable participate condition risk laboratory subject abnormalities study presence Cluster 1025: hcg iu units sensitivity chorionic gonadotropin minimum test equivalent pregnancy Cluster 1026: fcbp lenalidomide pregnancy effective method days agree commit begin starts Cluster 1027: sexual end partner male wocbp contraception adequate willing use weeks Cluster 1028: examination physical registration history days prior complete patients medical digital Cluster 1029: microbial anti acceptable infection prophylaxis parenteral infections guidelines agents uncontrolled Cluster 1030: unacceptably places toxicities high risk condition opinion medical investigator patient Cluster 1031: anti pd programmed death ligand cell antibody ctla lymphocyte cytotoxic Cluster 1032: adenocarcinoma cytologically histologically confirmed prostate rectum colon diagnosis breast metastatic Cluster 1033: hla donor drb allele loci identical haplotype related haploidentical recipient Cluster 1034: females years age male japan cancer presenting breast routine cervical Cluster 1035: aspartate aminotransferase ast uln hepatic days times metastases laboratory iu Cluster 1036: melanoma uveal ocular mucosal metastatic primary patients diagnosis histologic origin Cluster 1037: sgpt pyruvate glutamate transaminase serum normal upper limit uln iu Cluster 1038: ctcae grade nci version neuropathy ongoing infection uln peripheral toxicity Cluster 1039: creatinine mg clearance min ml dl serum calculated measured estimated Cluster 1040: immunotherapy vaccines type tumor completion days weeks completed initiation oncolytic Cluster 1041: diagnosis immunodeficiency confirmed time disease following patients histologic nf malignancy Cluster 1042: live receipt vaccine attenuated days dose prior study ip treatment Cluster 1043: board irb review approved sign document institutional informed consent understand Cluster 1044: individuals antiretroviral combination hiv ineligible positive immunodeficiency virus human therapy Cluster 1045: unwillingness inability consent informed supplementation written transfused vitamin individual folic Cluster 1046: pregnant patient currently participants plan study subjects trying women non Cluster 1047: irb board review approved sign understand able institutional document informed Cluster 1048: qt points resting ecg msec family qtc long electrocardiogram hour Cluster 1049: free malignancy situ skin carcinoma cervix years melanoma cancer non Cluster 1050: cypa strong inhibitors rifampin phenytoin ketoconazole carbamazepine inducers itraconazole cytochrome Cluster 1051: angina myocardial infarction unstable months history prior day study enrollment Cluster 1052: women postmenopausal fsh defined hormone bilateral potential follicle menarche amenorrhea Cluster 1053: fludarabine cyclophosphamide hypersensitivity immediate reaction severe history phosphate aldesleukin clofarabine Cluster 1054: hematological function adequate acceptable values biological malignancies defined confirmed status Cluster 1055: bilirubin uln total direct levels subjects serum initiation days performed Cluster 1056: vs host graft transplant stem disease elapsed cell active rescue Cluster 1057: guardian legal consent informed patient parent able provide written sign Cluster 1058: guardians parents legal sign consent written informed patients benefits indicating Cluster 1059: guardian informed explained consent copy understood patient signed given procurement Cluster 1060: deficiency immune acquired aids hiv syndrome immunodeficiency virus human known Cluster 1061: platelets mcl initiation days performed treatment labs ul prior working Cluster 1062: older age years men women female patients time eighteen subjects Cluster 1063: sgot glutamic oxaloacetic transaminase aspartate ast aminotransferase uln serum institutional Cluster 1064: malignancy melanotic cancer cervix situ exceptions skin carcinoma non specific Cluster 1065: hodgkin lymphoma non nhl refractory relapsed cell classical confirmed histologically Cluster 1066: revassist program mandatory registered comply willing requirements able participants study Cluster 1067: iuln bilirubin institutional upper normal limit total gilberts registration syndrome Cluster 1068: prisoners excluded vulnerable study eligible considered individuals pregnant populations children Cluster 1069: total bilirubin upper limit normal stenting biliary institution laboratory age Cluster 1070: transfusions hemoglobin dl hgb allowed receive blood days permitted permissible Cluster 1071: gault cockcroft clearance creatinine min ml formula calculated renal function Cluster 1072: lymphoma lymphocytic zone marginal follicular cell small mantle leukemia sll Cluster 1073: unresolved toxicities grade criteria ctcae alopecia terminology common exception adverse Cluster 1074: men wocbp sexually contraception instructed nivolumab azoospermic adhere active women Cluster 1075: drug study administration dose days prior weeks following therapy treatment Cluster 1076: azathioprine necrosis methotrexate thalidomide immunosuppressive medications tnf systemic anti cyclophosphamide Cluster 1077: schedule adhere visit requirements protocol able study willing ability consent Cluster 1078: pregnancy pregnant test women positive breastfeeding serum lactating study urine Cluster 1079: uncompensated severe respiratory diseases uncontrolled evidence systemic unstable cardiac hepatic Cluster 1080: adenocarcinoma histologic prostate diagnosis confirmation cytologic rectum colon patients evidence Cluster 1081: sexually males contraception effective childbearing potential use active accepted women Cluster 1082: infection improvement despite exhibiting signs bacterial fungal antibiotics viral appropriate Cluster 1083: myeloma imwg working international multiple group criteria diagnosis according diagnostic Cluster 1084: hepatitis virus indicating sag hcv hbv ribonucleic surface positive antigen Cluster 1085: minor placement procedure access surgical excluding vascular biopsy core device Cluster 1086: components hypersensitivity known study analogs drugs drug patients niraparib patient Cluster 1087: postmenopausal women status defined menstrual patient premenopausal female months year Cluster 1088: suspected metastasis leptomeningeal brain known active disease subject needing carcinomatosis Cluster 1089: subfamily cytochrome polypeptide family cypa cypc inhibitors strong medications inducers Cluster 1090: neuropathy peripheral grade enrollment patient days applicable ahct ctcae initiation Cluster 1091: hla matched leukocyte donor antigen human unrelated related drb sibling Cluster 1092: platinum based chemotherapy regimen line disease received prior therapy progression Cluster 1093: addiction alcohol drug illicit ongoing caregiver drugs active assessed known Cluster 1094: men women age years ages greater patients adult status country Cluster 1095: seizure cortical predispose trauma stroke brain history condition consciousness significant Cluster 1096: anc neutrophil absolute count days ul prior treatment study cells Cluster 1097: brain metastasis ct mri metastases exclude imaging scan neurological symptoms Cluster 1098: reach hemoglobin dl transfusion cut transfused acceptable subjects hgb level Cluster 1099: imaging resonance magnetic tomography computed ct mri scan measurable disease Cluster 1100: social illness compliance psychiatric requirements limit situations study situation ability Cluster 1101: histology cell small carcinoma mixed squamous adenocarcinoma clear cytology variant Cluster 1102: male contraception agree study use barrier subjects dose method drug Cluster 1103: restrictions men apply birth control study practicing regulations regarding sexually Cluster 1104: matched partially hla donor member family antigen related restricted cells Cluster 1105: organ function adequate including demonstrates baseline days following evidenced registration Cluster 1106: malignancy concurrent requiring active intervention therapy treatment participants immediate requires Cluster 1107: pancreas adenocarcinoma histologically cytologically confirmed metastatic proven resectable patients ductal Cluster 1108: tumor primary brain patients biopsies positive biopsy metastatic diagnosis resection Cluster 1109: pregnant participating inform immediately suspect woman physician treating study partner Cluster 1110: room air perform forced predicted capacity pulmonary oximetry fvc pulse Cluster 1111: pancreatitis chronic acute renal known liver disease history symptomatic patients Cluster 1112: interstitial fibrosis lung pulmonary pneumonitis disease history pneumonia extensive idiopathic Cluster 1113: pd durvalumab including inhibitor previous tremelimumab ctla treatment anti pdl Cluster 1114: estimated expectancy life months greater investigator patients entry treating physician Cluster 1115: hg pressure mm systolic blood hypertension diastolic uncontrolled despite bp Cluster 1116: retain swallow oral medication able ability subject medications patient orally Cluster 1117: desquamating nodosum characterized erythema rash thalidomide development taking similar drugs Cluster 1118: member haplotype family matched single donor suitable investigator subject falls Cluster 1119: anc ul cells mcl ml cohort cumm liter granulocytes platelets Cluster 1120: zubrod performance status patients ps karnofsky score criteria scale equal Cluster 1121: small prostate carcinoma cell neuroendocrine consistent pathological finding histologic diagnosis Cluster 1122: inr range normalized ratio international coumadin therapeutic anticoagulant normal enroll Cluster 1123: mol mg dl creatinine serum bilirubin si total function male Cluster 1124: inappropriate make medical condition psychiatric study patient investigator judgment participation Cluster 1125: specified protocol therapy concomitant pre use meet patients laboratory requirements Cluster 1126: cancer malignancies excluded present invasive contraindicates melanoma exception skin years Cluster 1127: inducer cypa strong inhibitor potent cytochrome medication use enzyme days Cluster 1128: performance status adequate patients better good considered protocol level patient Cluster 1129: autoimmune disease syndrome sclerosis guillain systemic granulomatosis barre vasculitis erythematosus Cluster 1130: work carry light activities office able house activity walk physically Cluster 1131: informed federal accordance nature guidelines institutional consent investigational written sign Cluster 1132: eligibility step criteria registration randomization pre verify induction patients change Cluster 1133: transplant organ solid prior marrow bone history hematologic requiring immunosuppressive Cluster 1134: creatinine mg dl serum umol equal registration days prior renal Cluster 1135: institute national terminology events common adverse nci ctcae grade criteria Cluster 1136: abstinent agreement remain methods contraceptive rate year period dose women Cluster 1137: cyp cytochrome strong inhibitor requires treatment inducer subfamily inhibitors use Cluster 1138: steroid prednisone therapy equivalent immunosuppressive mg systemic immunodeficiency receiving form Cluster 1139: trastuzumab emtansine prior treatment lapatinib patients therapy ado chemotherapy regimen Cluster 1140: heart york association new failure nyha congestive grade cardiac iii Cluster 1141: plt platelet count ul mm registration obtained days prior peripheral Cluster 1142: mmol potassium serum sodium normalize registration levels despite intervention days Cluster 1143: grapefruit seville oranges juice study star containing fruits fruit products Cluster 1144: hematopoietic transplant stem cell autologous prior allogeneic months received relapse Cluster 1145: adverse events recovery supportive toxicities ctcae terminology common nonsignificant version Cluster 1146: therapies prior number received cancer anti patients allowed systemic limit Cluster 1147: prostatectomy prostate prior cancer therapy cryosurgery cryotherapy radiation hyperthermia patients Cluster 1148: provide ability informed consent willingness english follow patient adhere assessments Cluster 1149: injectables combined implants contraceptives devices partner iuds intrauterine condoms oral Cluster 1150: menopausal hormone postmenopausal post age fsh follicle oophorectomy bilateral stimulating Cluster 1151: hiv load viral cd immunodeficiency antiretroviral virus human positive haart Cluster 1152: old lansky years karnofsky performance score patients status younger individuals Cluster 1153: hiv infection known history patients status testing subjects test htlv Cluster 1154: msecs qtc interval corrected qt formula using bazetts bazett prolongation Cluster 1155: brain mri metastases imaging ct resonance magnetic contrast weeks tomography Cluster 1156: oximetry pulse dyspnea rest exercise room air intolerance evidence indication Cluster 1157: lipase uln serum times institutional registration pancreatitis capmatinib screened institutions Cluster 1158: philadelphia chromosome ph positive abl kinase bcr tyrosine patients tki Cluster 1159: pd anti pathway targeting antibody therapeutic agents agonists ctla treatment Cluster 1160: procedures comply inability protocol required study knowledge visits likely subject Cluster 1161: junction gastroesophageal adenocarcinoma gastric gej esophagus histologically confirmed stomach metastatic Cluster 1162: transfusions provided red known platelet evaluable counts hematologic receive toxicity Cluster 1163: egfrmut antineoplastic tm met phase egfr ii group tki nave Cluster 1164: chemotherapy prior weeks patients treatment systemic dose days regimen study Cluster 1165: scale karnofsky performance kps status score lansky ps higher greater Cluster 1166: pneumonitis idiopathic fibrosis organizing pneumonia induced pulmonary chest history scan Cluster 1167: wort st johns john herbal hypericum perforatum remedy rifampin use Cluster 1168: sensory neuropathy grade peripheral preexisting baseline greater patients evidence equal Cluster 1169: neoadjuvant chemotherapy therapy planned received surgery cancer prior breast patients Cluster 1170: unwillingness inability procedures follow comply protocol required study outlined cooperate Cluster 1171: surgery major registration prior days weeks study eligible diagnostic patients Cluster 1172: ng psa ml level prostatectomy serum nadir prostate vitamin post Cluster 1173: crcl creatinine min ml clearance calculated serum uln measured renal Cluster 1174: bacillus tb tuberculosis active known history patient step infection registration Cluster 1175: immunodeficiency test human virus hiv positive result screening history known Cluster 1176: cns metastases symptomatic untreated patients active known uncontrolled excluded brain Cluster 1177: predisposition inherited thrombosis bleeding known hypercoagulable history state patient jeopardize Cluster 1178: sorafenib hcc prior treatment systemic therapy received intolerance progression patients Cluster 1179: starting weeks received effects therapy drug study recovered prior nitrosourea Cluster 1180: infections uncontrolled active severe conditions acute chronic including systemic clinically Cluster 1181: angina unstable months prior entry intervention disease medical surgical study Cluster 1182: cardiovascular significant disease clinically uncontrolled history pulmonary active diseases months Cluster 1183: immunoglobulin light chain protein serum free kappa monoclonal mg lambda Cluster 1184: cpi treatment weeks cancer initiation past investigational prior received dose Cluster 1185: toxicities recovered related grade prior treatment radiotherapy patients radiation therapies Cluster 1186: herbal ephedra kava gingko yohimbe ginseng medications dehydroepiandrosterone biloba ma Cluster 1187: spinal cord compression untreated brain metastases leptomeningeal symptomatic metastasis stable Cluster 1188: platelet help transfusions meet eligibility allowed criteria days count enrollment Cluster 1189: procedures provide informed consent written study prior specific screening related Cluster 1190: hepatitis known positive history patients tests active viral load infection Cluster 1191: neutrophils ul absolute days obtained cells registration mm randomization count Cluster 1192: nonsteroidal nsaids aspirin inflammatory anti drugs agents use day nsaid Cluster 1193: heparin low molecular weight warfarin anticoagulation therapeutic aspirin dose anticoagulants Cluster 1194: parameters hematologic adequate transfusional support hepatic renal laboratory defined ongoing Cluster 1195: ul platelet count days prior cells untransfused obtained treatment thrombocytopenia Cluster 1196: fertile unwilling contraceptive practice methods men period study appropriate follow Cluster 1197: radiation weeks therapy prior study treatment dose enrollment chemotherapy drug Cluster 1198: randomization prior weeks months days therapy treatment date time laboratory Cluster 1199: irae grade event immune unresolved adverse related immunotherapy receiving previous Cluster 1200: verification histologic diagnosis original neuroblastoma relapse patients tumors tumor malignancy Cluster 1201: taken half investigational lives days shorter whichever agents minimum drug Cluster 1202: procurement criteria time inclusion exclusion pending patients cell infection expectancy Cluster 1203: pulmonary carbon monoxide dlco oxygen capacity function diffusing saturation room Cluster 1204: ulcer peptic disease active gastritis history gastrointestinal months esophagitis bleeding Cluster 1205: diet mdrd glomerular filtration formula modification rate renal min ml Cluster 1206: males mg dl females creatinine years age serum maximum gender Cluster 1207: requires immunosuppressive organ transplant use undergone treatment medications history fallopian Cluster 1208: expectancy life investigator opinion months weeks determined greater judgment assessed Cluster 1209: english read understand able speakers ability questions respond unable written Cluster 1210: tablets swallow able capsules intact patients inability nasogastric ribociclib tube Cluster 1211: cohorts expansion participants enrolled patients combination dose disease treatment prior Cluster 1212: effusions pleural ascites malignant pericardial significant patients exudative symptomatic peritoneal Cluster 1213: antiretroviral combination undertaken hiv therapy studies indicated appropriate immunodeficiency virus Cluster 1214: contraceptive reproductive method potential effective agreed use women participate pregnant Cluster 1215: prohibited use bisphosphonates huang yohimbe ephedra kava ginseng concurrent ma Cluster 1216: resolved grade toxicity prior related therapy acute alopecia previous treatment Cluster 1217: alimentation affecting requirement absorption gastrointestinal disease inability oral procedures intravenous Cluster 1218: contraceptive measures reproductive bilateral effective pregnancy celibacy potential chooses heterosexually Cluster 1219: fcbp females childbearing pregnancy potential agree testing ongoing practice contraception Cluster 1220: plasma leukemia current cell past diagnosis faint family fap fanconi Cluster 1221: dependent transfusion thrombocytopenia oxygen anemia patient presence patients pacemaker maintained Cluster 1222: repair aortic aneurysm arterial vascular thrombosis recent peripheral surgical significant Cluster 1223: intolerable ineffective standard proven advanced exist locally therapy metastatic solid Cluster 1224: allografts organ patients transplant renal excluded history transplants subjects subject Cluster 1225: revascularization ischemic coronary symptoms history cardiac events including acs mi Cluster 1226: neutrophil absolute anc count obtained registration days prior mm mcl Cluster 1227: infusion lymphocyte donor dli days cell received prior infusions enrollment Cluster 1228: marrow bone involvement count neutrophil absolute anc unless platelet cytopenias Cluster 1229: patient cognitive information compromise complete psychiatric comply study conditions ability Cluster 1230: autoimmune subjects excluded syndrome atopy childhood systemic bronchodilators intermittent injections Cluster 1231: antibodies monoclonal hypersensitivity reactions severe history mabs allergy humanized reaction Cluster 1232: wound healing surgery major trauma fracture dose ulcer days non Cluster 1233: agent investigational receiving patients currently received weeks days agents study Cluster 1234: excluded subjects metastases brain clinical trial cancers treated cns primary Cluster 1235: indicative months dose teaspoon hemoptysis hemorrhage signs red treatment pulmonary Cluster 1236: locally advanced metastatic disease unresectable resectable therapy patients prior treatment Cluster 1237: unwilling unable study participate discontinue undergo use patients contraception prohibited Cluster 1238: judged investigator clinically significant infections treating limits disability institutional intake Cluster 1239: hemorrhage bleeding event grade ctcae weeks nci study start prior Cluster 1240: urine pregnancy childbearing test negative potential women serum days prior Cluster 1241: ldh lactate dehydrogenase uln serum normal upper times limit level Cluster 1242: heart arterial thrombotic evidenced disease infarction myocardial measurement york unstable Cluster 1243: common terminology ctcae adverse events grade criteria version diarrhea toxicity Cluster 1244: toxicities grade related alopecia prior recovery resolution therapy treatment significant Cluster 1245: unl bilirubin aminotransferase upper limit normal serum transaminase ast metastases Cluster 1246: dose study contraception adequate days use participants potential childbearing method Cluster 1247: gvhd acute chronic active prophylaxis patients systemic treatment overlap grade Cluster 1248: splenic irradiation splenectomy months prior current history mmb immunodeficiency drug Cluster 1249: temsirolimus mtor everolimus sirolimus rapamycin inhibitor mammalian prior treatment target Cluster 1250: lansky karnofsky performance status score dependent adult pediatric age kps Cluster 1251: infection uncontrolled eligible patients subjects active stratum untreated study participation Cluster 1252: cells platelets mm registration days prior obtained si study ml Cluster 1253: ischemic attack stroke transient infarction myocardial angina unstable months heart Cluster 1254: cns involvement nervous central puncture lumbar active known patients disease Cluster 1255: institutional regulatory dated accordance board review guidelines signed irb approved Cluster 1256: hemophilia von bleeding willebrands disorders known willebrand disease diathesis predisposition Cluster 1257: capacity lung supplementary oxygen monoxide dlco carbon expiratory continuous fev Cluster 1258: electrocardiogram qtc msec qt corrected interval ecg screening ekg baseline Cluster 1259: procedure surgical major prior weeks days study day treatment surgery Cluster 1260: presence infection uncontrolled active hours disease cancer chronic invasion major Cluster 1261: inflammatory breast cancer patients diagnosis subjects patient carcinoma td metastatic Cluster 1262: disorder bleeding history bipolar psychiatric autoimmune known patients active anxiety Cluster 1263: inappropriate make judgment concurrent severe investigator patient morbidity disease infection Cluster 1264: lower ejection fraction left ventricular normal limit lvef lln institutional Cluster 1265: ductal carcinoma dcis situ breast invasive cancer treated diagnosis history Cluster 1266: lymphoma large cell diffuse dlbcl follicular mediastinal primary transformation nhl Cluster 1267: treated adequately evidence malignancy situ disease lentigo maligna melanoma cancer Cluster 1268: instructions staff compliance comply given unwilling regimens medical unable non Cluster 1269: meningeal brain tumors metastatic symptomatic asymptomatic leptomeningeal allowed definitive treated Cluster 1270: responded refractory primary mr therapy prior participants eligible egfr disease Cluster 1271: bilirubin gilberts mg dl total syndrome patients unless uln equal Cluster 1272: pomalidomide prior previous treatment therapy exposure received combination pregnancy dexamethasone Cluster 1273: cns disease patients lymphoma nervous central active leukemia primary eligible Cluster 1274: fev expiratory dlco forced monoxide predicted carbon volume capacity second Cluster 1275: noncompliance regimens medical history haart unreliable protocol comply unable therapy Cluster 1276: vaccinated attenuated vaccines live weeks drug dose study starting tremelimumab Cluster 1277: pregnant planning feeding breast breastfeeding study months pregnancy female lactating Cluster 1278: ef ejection fraction ventricular left cardiac echocardiogram heart dimensional uncontrolled Cluster 1279: area body surface enrollment patients bsa time study design dose Cluster 1280: hepatitis surface antibody antigen positive virus negative hiv core immunodeficiency Cluster 1281: age time years consent enrollment informed diagnosis study months patients Cluster 1282: unwilling follow unable requirements protocol consent instruction informed render instructions Cluster 1283: esophageal varices gastric bleeding history cancer variceal months prior patients Cluster 1284: leptomeningeal metastasis brain disease history known symptomatic presence active patients Cluster 1285: inadequate function renal organ liver marrow bone hematologic hepatic evidenced Cluster 1286: vaccination live vaccine days prior start treatment minimum attenuated received Cluster 1287: lung cancer radiation prior therapy patients chemotherapy diagnosis screening surgery Cluster 1288: inhibitors cypa boosted boceprevir telaprevir ritonavir cobicistat ciprofloxacin diltiazem olaparib Cluster 1289: infiltrates chest pulmonary improving ray presumed fungal progressive attributed infections Cluster 1290: torsades pointes medications risk known qt prolongation associated qtc causing Cluster 1291: new counter considering counseled medications interactions medicine prescribed patient herbal Cluster 1292: bladder cancer superficial radiation invasive prior history diagnosis patient tumor Cluster 1293: qtc interval qt corrected milliseconds prolongation baseline demonstration marked repeated Cluster 1294: alc lymphocyte absolute count ul mm cells blood cell product Cluster 1295: polysorbate formulated hypersensitivity drugs docetaxel reaction history severe reactions containing Cluster 1296: crohn colitis ulcerative disease inflammatory bowel active gastrointestinal documented resection Cluster 1297: immunodeficiency virus human infection known history subject immunosuppressive testing disease Cluster 1298: abdominal diverticulitis abscess carcinomatosis obstruction intra gi coming gastrointestinal acute Cluster 1299: block lafb rbbb fascicular excluded av anterior degree conduction right Cluster 1300: mm accurately dimension longest diameter recorded measured spiral measurable techniques Cluster 1301: infections requiring systemic active antibiotics therapy chronic suppressive maintenance infection Cluster 1302: experimental drug therapy study days use weeks treatment prior baseline Cluster 1303: curatively primary cancer treated resected outcome cervical skin present solid Cluster 1304: indicating purpose procedures understands study participate willing required consent informed Cluster 1305: hb hemoglobin dl gm level transfusion correct transfusions equal anemia Cluster 1306: bilirubin serum normal equal indirect count direct family fap fanconi Cluster 1307: severe infections weeks prior day cycle infection enrollment randomization systemic Cluster 1308: creatinine clearance calculated crcl uln place gfr glomerular filtration institutional Cluster 1309: agreed reproductive sexually contraceptive effective duration method potential participation use Cluster 1310: deciliter grams hemoglobin dl gram liter albumin millimoles equal level Cluster 1311: nivolumab predisposition hepatoxicity caution drugs used containing regimen treated hepatotoxicity Cluster 1312: positivity antiretroviral combination hiv immunodeficiency virus human known therapy know Cluster 1313: antibody monoclonal weeks prior therapy treatment study received chemotherapy days Cluster 1314: proven biopsy diagnosis histologically cancer pathologically disease patients carcinoma breast Cluster 1315: consecutive mature potential months naturally childbearing sexually hysterectomy undergone postmenopausal Cluster 1316: provision consent informed procedures specific written study prior signed participate Cluster 1317: speak read english able understand ability unable fluently patients inability Cluster 1318: growth factor support neutrophil absolute count anc mcl ul days Cluster 1319: signing consent informed age years time form day female subject Cluster 1320: transfusion meet inclusion blood allowed criteria mm count hb neutrophil Cluster 1321: obtained newly specimen inaccessible archived excisional concern biopsy tissue submit Cluster 1322: effusion pleural ascites pericardial drainage requiring symptomatic uncontrolled recurrent fluid Cluster 1323: adjuvant neo chemotherapy therapy prior treatment months cancer received completion Cluster 1324: severe intercurrent infection sepsis patients medical infusion procurement acute conditions Cluster 1325: organ function marrow normal defined patients bone tests days subjects Cluster 1326: graft versus host disease active chronic grade treatment cgvhd criteria Cluster 1327: angina sick severe uncontrolled heart sinus electrocardiographic conduction ischemia pacemaker Cluster 1328: menarchal girls agreed females tests method entered pregnancy participate males Cluster 1329: immunostimulatory whichever lives half agents systemic shorter treatment drug weeks Cluster 1330: leukemia acute biphenotypic blasts myeloid diagnosis lymphoblastic marrow remission lineage Cluster 1331: wbc white blood cell count mm mcl days hydroxyurea registration Cluster 1332: menses year postmenopausal defined screening spontaneous prior post menopausal estradiol Cluster 1333: regimen chemotherapy prior received treatment patients therapy disease based regimens Cluster 1334: drugs supportive contraindication hydration treatments concomitant preexisting intolerance impairment required Cluster 1335: ich gcp conference local good written harmonization international consent informed Cluster 1336: surgery day major weeks prior study days diagnostic recovered treatment Cluster 1337: anc neutrophil absolute count ml platelet liter csf greater platelets Cluster 1338: albumin dl equal hypoalbuminemia screening greater plasma level levels low Cluster 1339: mmhg pressure despite diastolic management systolic hypertension optimal blood medical Cluster 1340: pain uncontrolled related tumor tumour cancer does hypercalcemia chronic favor Cluster 1341: language english read speak able primary understand unable proficient patient Cluster 1342: malignancy carcinoma cell curative basal low squamous prostate situ resection Cluster 1343: assess measurable scans mris disease used ct completed resonance magnetic Cluster 1344: score karnofsky performance status greater patients higher adult adequate time Cluster 1345: awareness indicating nature program signed investigational informed consent scheduling cct Cluster 1346: agents anti receiving cancer currently patients eligible investigational study entry Cluster 1347: aminotransferase uln ast alt aspartate alanine liver upper normal limit Cluster 1348: male female years creatinine subjects gender serum age patients maximum Cluster 1349: provide written informed consent patients willingness participate study participant voluntarily Cluster 1350: gi diarrhea vomiting nausea alter significantly malabsorption ulcerative absorption bowel Cluster 1351: altered mental prohibit dementia informed status consent understanding giving precluding Cluster 1352: positivity hiv immunodeficiency virus human known hepatitis procurement history active Cluster 1353: autoimmune requiring immunosuppressive disease active systemic therapy modifying history treatment Cluster 1354: cerebral meningeal underlying disease related malignancy metastases known hemorrhage active Cluster 1355: final study starting barrier administration birth method control screening period Cluster 1356: inability oral swallow medications medication gastrointestinal absorption unwillingness absorb administration Cluster 1357: allogenic transplant stem autologous organ cell solid history prior bone Cluster 1358: axillary nodes lymph mammary breast positive internal supraclavicular primary infraclavicular Cluster 1359: virus hepatitis seropositive hcv hbv hiv immunodeficiency human viral known Cluster 1360: contraception lifestyle usual preferred abstinence course acceptable study medication method Cluster 1361: contraception adequate beginning signing associate definition icf designated judgment principal Cluster 1362: hypersensitivity perflutren known drug suspected products study acyclovir definity patients Cluster 1363: swallow tablet capsule able drugs ability study liquids drug unable Cluster 1364: cancer treated situ curatively distinct superficial carcinoma bladder cervical years Cluster 1365: mmhg pressure blood systolic diastolic hypertension controlled uncontrolled defined inadequately Cluster 1366: heart york association new ii congestive greater failure nyha grade Cluster 1367: live vaccines attenuated study days weeks vaccinations treatment prior vaccination Cluster 1368: lactating females pregnant donor feed exclusion intend excluded criteria agree Cluster 1369: smoking cigarette prolonged respiratory tested expiratory fev forced predicted dysfunction Cluster 1370: stem transplant allogeneic cell prior patients received eligible history previous Cluster 1371: oxygen dyspnea rest continuous complications supplementary advanced malignancy requiring therapy Cluster 1372: practice agree entire contraception barrier effective period study dose sterilized Cluster 1373: antibiotics iv oral prophylactic urinary tract obstructive prevention weeks day Cluster 1374: assistance questionnaire complete ability diary medication english qol independently diaries Cluster 1375: toxicities terminology common ctcae alopecia adverse grade events criteria version Cluster 1376: prior study criteria therapy disease treatment patients weeks history inclusion Cluster 1377: aspects comply willing able protocol subject informed participant consent participants Cluster 1378: steroids topical systemic inhaled use steroid immunosuppressive treatment doses replacement Cluster 1379: pertuzumab trastuzumab emtansine dm prior ado therapy lapatinib setting metastatic Cluster 1380: implanted devices electronic device pacemakers pacemaker defibrillators defibrillator stimulator brain Cluster 1381: logistics feasibility issues prospective comply procedures compliance opinion related able Cluster 1382: upcr protein urine ratio creatinine urinalysis hour cabozantinib mg spot Cluster 1383: swallow able study drug tablet comply requirements enzalutamide intolerance oral Cluster 1384: hbv hcv infection hiv active known htlv history deficiency disease Cluster 1385: impaired function decisionally cognitively renal patients absorption egfr severely gastrointestinal Cluster 1386: plasma bone marrow cells dl clonal myeloma mg lesions serum Cluster 1387: gleason psa prostate score risk ng stage ml tb intermediate Cluster 1388: anthracycline therapy prior received chemotherapy based containing exposure regimen patients Cluster 1389: bacterial fungal viral infection active uncontrolled systemic time enrollment controlled Cluster 1390: infertility exists documentation practice effective fertile unless men contraceptive methods Cluster 1391: surgery radiation therapy weeks treatment major chemotherapy prior study recovered Cluster 1392: paraffin formalin fixed embedded ffpe tumor tissue slides block availability Cluster 1393: major surgery days prior dose treatment study immunotherapy patients entering Cluster 1394: lower limit normal range potassium lln upper institutional times hemoglobin Cluster 1395: measureable recist disease lesion version defined radiographically criteria presence according Cluster 1396: tolerate inability opinion treating procedures investigator imaging physician predispose rapidly Cluster 1397: shorter whichever half lives therapy weeks prior investigational chemotherapy treatment Cluster 1398: urine test pregnancy negative serum hours medication female childbearing required Cluster 1399: cns radiographic completion metastases directed hemorrhage interim provided anticonvulsants optic Cluster 1400: values range laboratory defined having patient function protocol outside hepatic Cluster 1401: autoimmune disease systemic erythematosus lupus vasculitis bowel inflammatory rheumatoid arthritis Cluster 1402: stroke history months accident hemorrhagic cerebrovascular cerebral hemorrhage prior known Cluster 1403: prothrombin inr normalized pt ratio international time uln normal seconds Cluster 1404: fathering form acceptable medically birth control childbearing child willing potential Cluster 1405: malignancy melanomatous cancer skin curatively resected non adequately concurrent basal Cluster 1406: world organization health diagnosis performance status classification aml criteria confirmed Cluster 1407: age score years lansky performance karnofsky lps status scale kps Cluster 1408: pelvis radiation prior abdomen radiotherapy therapy outside metastatic previous treatment Cluster 1409: prolonged qtc interval qt corrected msec history electrocardiogram calculated rate Cluster 1410: threatening stroke cardiovascular arrhythmia unstable infarction myocardial life problems congestive Cluster 1411: alkaline phosphatase normal upper limit uln institutional alk limits liver Cluster 1412: rems adhere program revlimid scheduled reproductive testing females pregnancy required Cluster 1413: unwillingness inability comply protocol participate duration study reason requirements written Cluster 1414: uncontrolled arrhythmia significant clinically cardiac condition symptomatic arrhythmias medical confounding Cluster 1415: screening prior months days weeks hospitalization positive date therapy time Cluster 1416: neuropathy peripheral grade patients baseline ctcae presence preexisting cause current Cluster 1417: anticonvulsants inducing enzyme seizure disorder controlled enrolled patients non receiving Cluster 1418: decreasing stable dose corticosteroids corticosteroid prior days receiving enrollment patients Cluster 1419: malignancy currently second cancers melanoma active non skin considered completed Cluster 1420: aged older years male female females time males men adult Cluster 1421: antibody decline colonic allow colonoscopy receives preparative time elapsed anti Cluster 1422: uncontrolled medical jeopardized disorder illnesses malignant infection active non infections Cluster 1423: calcium mg registration dl days corrected serum step documented prior Cluster 1424: autoimmune syndrome systemic disease patients immune history demyelinating recur phospholipid Cluster 1425: th edition ajcc stage joint committee american cancer staging iv Cluster 1426: recurrence local therapy disease progression evidence patients cancer radiation treatment Cluster 1427: plt platelets mm transfusions mcl days ml obtained start registration Cluster 1428: sct autologous allogeneic stem cell prior transplant transplantation auto days Cluster 1429: transurethral turp prostate resection prior prostatic surgery cryotherapy including procedure Cluster 1430: surgery major weeks dose prior study subject radiation lenvatinib treatment Cluster 1431: diabetes uncontrolled mellitus hypertension unreasonably hazardous medical disease sugar hypothyroidism Cluster 1432: cognitive impairment consent psychiatric preclude informed significant mental study participation Cluster 1433: compulsorily detained physical infectious illness psychiatric subjects treatment disease prisoners Cluster 1434: anaphylactic allergic reactions severe monoclonal antibody history reaction humanized murine Cluster 1435: survival anticipated months patient incompatible illness medical organ major failure Cluster 1436: warfarin anticoagulation inr pt receiving patients therapeutic prophylactic dose therapy Cluster 1437: measures contraceptive potential pregnancy bearing feeding dosing child start negative Cluster 1438: thrombotic uremic thrombocytopenic purpura hemolytic microangiopathy syndrome history hus ttp Cluster 1439: hematologic toxicity evaluable transfusions patients limiting provided enrolled observed red Cluster 1440: ovarian cancer epithelial platinum breast patients treatment prior borderline recurrent Cluster 1441: solid histologically cytologically confirmed tumor advanced standard metastatic diagnosis tumors Cluster 1442: liver disease chronic history significant known clinically active severe evidence Cluster 1443: donor age years matched related haploidentical sibling morbidity score yr Cluster 1444: mcl anc neutrophil absolute count registration days prior performed equal Cluster 1445: attorney power durable sign willing dpa consent informed consented understand Cluster 1446: antiarrhythmic class ia iii procainamide sotalol dofetilide amiodarone quinidine receiving Cluster 1447: legal incapacity capacity limited subject providing patients granted authorization guardian Cluster 1448: pugh cirrhosis child liver class score classification present patients worse Cluster 1449: ild interstitial lung pneumonitis history disease induced evidence active drug Cluster 1450: uncontrolled active places unacceptable signing prevent hemorrhage artery mellitus coronary Cluster 1451: tomography emission positron pet ct computed scan imaging disease mri Cluster 1452: infections disorders illnesses respiratory cardiovascular coagulation restrictive immune active major Cluster 1453: pneumonitis organizing pneumonia fibrosis obliterans bronchiolitis cryptogenic idiopathic induced chest Cluster 1454: contraception contraceptives intrauterine barrier methods device effective potential oral contraceptive Cluster 1455: dlbcl lymphoma transformed fl confirmed histologically indolent refractory cell novo Cluster 1456: muscle invasive bladder urothelial carcinoma non cancer ta transitional high Cluster 1457: prostate proven adenocarcinoma biopsy histologically cancer histopathological histopathologically pathologically histopathology Cluster 1458: microliter platelets wbc transfusion randomization independent factors growth granulocytes prior Cluster 1459: bilirubin mg dl serum direct umol patients total days prior Cluster 1460: modification diet mdrd renal creatinine min ml calculated equation disease Cluster 1461: lactating women pregnant excluded study eligible childbearing intending potential cohort Cluster 1462: iron overload hemochromatosis parenteral dextran subjects transferrin anemia ferritin known Cluster 1463: multigated acquisition muga echocardiogram fraction ejection left scan ventricular echo Cluster 1464: therapy herbal cycle week day prior anticancer weeks contraceptives radiotherapy Cluster 1465: nursing women pregnant following plan arm trial breastfeeding exclusion participate Cluster 1466: previously received patients study subjects therapy untreated treatment radiation participated Cluster 1467: hepatitis seronegative antibody antigen tested rna rt pcr hcv reverse Cluster 1468: tolerate compromise significant ability patients therapy opinion medical illness illnesses Cluster 1469: illness intercurrent uncontrolled limited including concurrent significant infection subject patient Cluster 1470: adrenal insufficiency uncontrolled history chronic replacement disease therapy liver maintenance Cluster 1471: major traumatic injury surgery significant study effects recovered days weeks Cluster 1472: target lesion measurable recist disease criteria lesions radiation response tumor Cluster 1473: recovered grade note therapy prior qualify molecule criterion targeted administered Cluster 1474: platelets mcl registration days prior obtained study performed mm step Cluster 1475: herpetic keratitis encephalitis complications lesions skin active infection hsv intermittent Cluster 1476: individuals malignancy years eligible following circumstances history recurrence different cell Cluster 1477: allogeneic transplant marrow bone prior received previous organ history stem Cluster 1478: donate sperm study agree dose drug months intend eggs receiving Cluster 1479: hemodialysis dialysis peritoneal renal patients failure requiring requirement replacement therapy Cluster 1480: sgpt upper sgot alt limit normal ast institutional uln liver Cluster 1481: disorders autoimmune inflammatory active documented immunosuppressive prior history requiring therapy Cluster 1482: intrauterine device placement established pregnancy confirmed women iud containing contraceptive Cluster 1483: ischemic revascularization artery event procedures including fibrillation attack cerebrovascular transient Cluster 1484: gilbert syndrome history known disease diagnosis patients eligible bilirubin glucuronidation Cluster 1485: bilirubin serum uln institutional gilberts pretreatment institutions equal levels level Cluster 1486: gi manifestations reason alter unknown malabsorption gastrointestinal absorption mln stomata Cluster 1487: coagulation anti adequate profile acceptable function disorder defects status parameters Cluster 1488: bi dimensionally measurable cm lesion dimensional disease ct dimension scan Cluster 1489: polyneuropathy organomegaly endocrinopathy poems changes monoclonal syndrome skin protein gammopathy Cluster 1490: pregnancy childbearing female negative test potential serum patients enrollment days Cluster 1491: exhibit ecog eastern cooperative oncology group status performance patients directly Cluster 1492: availability tissue tumor archival sample fresh archived ffpe freshly specimen Cluster 1493: rule females urine pregnancy test childbearing potential feeding blood pregnant Cluster 1494: statin use current therapy donor pbsc months treatment drugs pravastatin Cluster 1495: ckd epi epidemiology collaboration kidney min creatinine ml chronic equation Cluster 1496: normal bilirubin upper limit range transaminases reference institution patients direct Cluster 1497: toxicities recovered grade therapy prior reversible chemotherapy effects previous alopecia Cluster 1498: virus infection hepatitis active immunodeficiency human hiv known positive chronic Cluster 1499: reserve marrow bone adequate inadequate demonstrated function organ evidenced laboratory Cluster 1500: compromise safety investigator opinion condition abnormality patient medical ability study Cluster 1501: integrity data investigators jeopardize opinion patient medical obtained compromise conditions Cluster 1502: bleeding clinically significant history unexplained entering days disorder study gastrointestinal Cluster 1503: xanthine rasburicase oxidase allergy inhibitors known contraindication allopurinol tls lysis Cluster 1504: weeks earlier administered monoclonal recovered adverse events antibody baseline prior Cluster 1505: leukemia lymphoma acute hodgkin chronic myeloid lymphocytic lymphoblastic myeloma remission Cluster 1506: equal greater age years karnofsky performance status lansky ecog participants Cluster 1507: receptor estrogen positive progesterone hormone breast cancer negative status tumor Cluster 1508: untreated infection active hepatitis presence patients uncontrolled previously systemic hypothyroidism Cluster 1509: viral hepatitis active chronic liver symptomatic disease cirrhosis nonviral known Cluster 1510: malabsorption condition absorption problem syndrome interfere intestinal syndromes history clinically Cluster 1511: donor hla haploidentical locus typing class recipient match serologic related Cluster 1512: age years adult patients subjects legal majority amenorrhea appropriate male Cluster 1513: arm patients study nivolumab prior exclusion randomized registration days treatment Cluster 1514: contraceptive device double methods women barrier bearing acceptable use child Cluster 1515: microliter hiv cd cells registration haart count positive note antiretroviral Cluster 1516: tacrolimus cyclosporine versus host post prevent transplant graft agents receiving Cluster 1517: seizures uncontrolled subjects patients history intracranial hypertension increased eligible pressure Cluster 1518: heart arrhythmias cardiovascular disease class infarction myocardial congestive symptomatic significant Cluster 1519: hematology values chemistry laboratory renal function biochemical liver adequate limits Cluster 1520: arterial cerebrovascular accident transient thromboembolic ischemic infarction myocardial angina attack Cluster 1521: immunosuppressives requires organ use transplant history disorders autoimmune steroids severe Cluster 1522: aminotransferase uln ast alt liver aspartate alanine metastases present metastasis Cluster 1523: mm anc granulocytes lymphocytes platelets count cells dl adequate hemoglobin Cluster 1524: indicated renal creatinine function adequate uln insufficiency upper level limit Cluster 1525: metastases meningitis carcinomatous brain evidence stability trial enlarging returned regardless Cluster 1526: bisphosphonate hypercalcemia osteoporosis therapy symptomatic reasons metastasis allowed use bone Cluster 1527: assistance questionnaires interpreter complete ability english questions minimal member able Cluster 1528: month prior treatment study enrollment therapy radiation use received past Cluster 1529: serology hiv positive immunodeficiency virus human known negative infection evidence Cluster 1530: ecog status functional mf performed acceptable patients fascia farber fap Cluster 1531: heart functional classification congestive cardiovascular york association arrhythmia class failure Cluster 1532: pugh hepatic impairment child class severe moderate patients baseline liver Cluster 1533: anti pd ctla prior checkpoint pdl cd antibody immune antibodies Cluster 1534: ongoing infection active uncontrolled illness including patients recent grade evidence Cluster 1535: lung small histologically cell cytologically non cancer confirmed nsclc stage Cluster 1536: bright hemoptysis teaspoon red blood episode month history prior day Cluster 1537: concurrently using antineoplastic approved patient anti neoplastic investigational therapy agent Cluster 1538: cancer carcinoma cell prostate cured thyroid gleason impact adequately unlikely Cluster 1539: hypersensitivity severe asthma monoclonal reactions antibodies nci anaphylaxis ctcae known Cluster 1540: severely lung impaired function interstitial concurrent condition severity history judged Cluster 1541: leptomeningeal metastases brain active cns evidence history known disease patients Cluster 1542: cardiomyopathy restrictive hypertrophic documented causes heart history cardiomegaly treatment significant Cluster 1543: scientifically compatible judged medically research enrolled drug type medical study Cluster 1544: access internet computer phone email smartphone regular mobile web tablet Cluster 1545: solid tumor advanced malignancy diagnosis histologic cytologic metastatic confirmation pathologically Cluster 1546: ventricular fibrillation atrial tachycardia arrhythmia contractions premature flutter uncontrolled controlled Cluster 1547: transplants stem cell prior organ allogeneic kind patients autologous transplant Cluster 1548: myelodysplastic myeloid leukemia acute syndrome mds aml suggestive features smear Cluster 1549: interstitial pneumonitis lung history disease active requiring patients radiation clinically Cluster 1550: creatinine clearance min ml uln calculated normal upper limit serum Cluster 1551: deficiency phosphate glucose dehydrogenase known history pd patients porphyria phosphatase Cluster 1552: female potential childbearing pregnancy test negative pregnant urine serum feeding Cluster 1553: entering radiotherapy prior study weeks chemotherapy patients therapy wait large Cluster 1554: able consent informed willing patients patient subjects study participants eligible Cluster 1555: exclusion registration criteria randomization neratinib secondary intraperitoneal experiencing mucinous borderline Cluster 1556: therapy biologic immunotherapy concurrent chemotherapy hormonal cancer treatment radiation embolization Cluster 1557: amenable curative advanced metastatic locally intent disease recurrent surgery therapy Cluster 1558: syndrome history gilberts patients stevens johnson known kostmann shwachman serotonergic Cluster 1559: arrhythmias cardiac uncontrolled ventricular history symptomatic pressor significant disease known Cluster 1560: leptomeningeal brain metastases disease symptomatic glucocorticoids uncontrolled continue treated require Cluster 1561: mm calipers exam ray recorded accurately longest dimension chest diameter Cluster 1562: colony stimulating granulocyte csf factor macrophage gm factors erythropoietin growth Cluster 1563: accept willing leukapheresis able procedures transfusions product blood biopsies randomization Cluster 1564: behavior suicidal study ideation inappropriate interpretation recent make increase judgment Cluster 1565: gog gynecologic oncology group performance status patients protocol priority rare Cluster 1566: pectoris symptomatic unstable congestive angina uncontrolled failure heart illness arrhythmia Cluster 1567: intention trials treat observational acceptable imaging agents investigational disease therapy Cluster 1568: hepatitis hbv virus positive hcv pcr antibody polymerase chain surface Cluster 1569: tolerance impair opinion investigator significant diseases treatment example trial inflammatory Cluster 1570: prestudy physical obtained registration history days prior exam pre study Cluster 1571: trial investigational participation clinical agent days drug prior treatment study Cluster 1572: milk stored future mother breastfeeding note pregnant breast treated use Cluster 1573: abide cooperate fully unwilling designee unable protocol investigator study subject Cluster 1574: proper prescribed inappropriate morbid illnesses make significantly judgment regimens safety Cluster 1575: prisoner patient subject incarcerated incompetent vulnerable mentally institutionalized person impending Cluster 1576: transfused gm hemoglobin dl rbcs achieve blood requirement prior level Cluster 1577: barrier birth control study method adequate contraception abstinence agree duration Cluster 1578: hypomagnesemia hypokalemia electrolyte hypocalcemia imbalance hyponatremia mmol lower corrected supplementation Cluster 1579: metastasis brain known parenchymal patients bony subjects history active treated Cluster 1580: myeloid leukemia acute aml relapsed refractory blasts marrow patients remission Cluster 1581: comply follow inability procedures study examinations able willing medical procedure Cluster 1582: white cells wbc blood mcl days ml ul wbcs administration Cluster 1583: pertinent aspects informed dated indicating signed document consent legally trial Cluster 1584: consecutive women effective months spermicide bearing child mature potential naturally Cluster 1585: min ml renal creatinine function gfr glomerular filtration rate adequate Cluster 1586: transplantation allogeneic prior autologous organ hematopoietic liver patients cell history Cluster 1587: unresolved toxicity grade previous alopecia therapy ctcae anticancer anti prior Cluster 1588: alkaline phosphatase uln metastases liver bone documented present involvement patients Cluster 1589: apl promyelocytic leukemia acute aml diagnosis diagnosed world organization health Cluster 1590: present previous enrollment study randomization enrolment assignment treatment family fap Cluster 1591: comply able protocol informed consent sign requirements signed willing icf Cluster 1592: crohns colitis ulcerative disease bowel inflammatory documented active prior history Cluster 1593: suitable intent curative administered local therapy disease urothelial cancer carcinoma Cluster 1594: coexisting likely condition medical procedures interfere results study psychiatric hazard Cluster 1595: urothelial carcinoma bladder tract cell histologically upper pure metastatic histologic Cluster 1596: female subject eligible defined enter amenorrhea follows childbearing participate potential Cluster 1597: fentanyl allergy history propofol opioids patches transdermal tolerant lidocaine midazolam Cluster 1598: gilberts bilirubin uln total syndrome disease patients unless documented subjects Cluster 1599: hematopoietic stem allogeneic transplant cell hsct transplantation prior previous autologous Cluster 1600: anticancer therapies offered lapatinib nf imatinib erlotinib basis bevacizumab antibody Cluster 1601: uncontrolled infection patients concurrent systemic hepatitis grade excluded evidence disease Cluster 1602: inability consent informed provide understand written obtain assent document sign Cluster 1603: cm size tumor dimension lesion tumors greatest patients disease greater Cluster 1604: comply ability willingness protocol study requirements procedures follow consent informed Cluster 1605: score eastern cooperative oncology group ecog performance equal ps subject Cluster 1606: embolic thrombotic attacks arterial thrombosis events cerebrovascular venous transient deep Cluster 1607: carcinoma histologically breast confirmed invasive cytologically primary metastatic operable non Cluster 1608: neck head squamous carcinoma cell histologically confirmed cancer hnscc scchn Cluster 1609: fertile unwilling use contraceptive men months techniques women post transplant Cluster 1610: cytotoxic weeks agents chemotherapy cytokines biologic antibodies nitrosoureas mitomycin investigational Cluster 1611: cerebrovascular accident cva months infarction myocardial history unstable angina mi Cluster 1612: ventricular tachycardia fibrillation history pointes arrhythmia torsades arrhythmias sustained clinically Cluster 1613: mgmt promoter unmethylated methylated tumor status gbm testing cohort methylation Cluster 1614: scans mri undergo able pet contrast tolerate patients unable willing Cluster 1615: rectal cancer colon digital prior adenocarcinoma surgery stage diagnosis stenosis Cluster 1616: pelvic radiation prior therapy previous history considered marrow bone patients Cluster 1617: ms qtcf fridericia qt corrected interval formula ecg screening subject Cluster 1618: good health general donor provider medical determined evaluating unstable generally Cluster 1619: cohort expansion patients dose criteria participants inclusion treatment specific phase Cluster 1620: pyruvate sgpt glutamate transaminase alt alanine uln aminotransferase upper limit Cluster 1621: hepatitis infection active known patients hiv evidence uncontrolled transmitting fluids Cluster 1622: eastern cooperative oncology group ecog scale participants enrollment current eligible Cluster 1623: events adverse biologic extended occurring agent occur known days agents Cluster 1624: genders practice birth control willing months time enrollment treatment patients Cluster 1625: urinary tract infection uncomplicated uti active requiring antibiotics infections exception Cluster 1626: dependence alcohol substance abuse drug history active current year past Cluster 1627: stage breast cancer iii ii diagnosed diagnosis early newly histologically Cluster 1628: glutamic transaminase aminotransferase pyruvic serum uln sgpt alt sgot oxaloacetic Cluster 1629: nutrition parenteral hydration tpn total dependency obstruction require gastrostomy tube Cluster 1630: scleroderma lupus active connective dermatomyositis collagen erythematosus tissue systemic disease Cluster 1631: feeding breast allowed enrollment active study farber fap fanconi fancd Cluster 1632: prolong interval qt qtc known medications drugs concomitant use taking Cluster 1633: female childbearing potential male contraception partners use effective patients agree Cluster 1634: brain carcinomatous compression meningitis spinal cord leptomeningeal new evidence metastases Cluster 1635: meningeal involvement nervous central carcinomatosis metastases signs cns brain clinical Cluster 1636: joint ajcc committee american stage cancer staging iv melanoma metastatic Cluster 1637: carcinoma prostate cancer cell basal situ squamous treated skin years Cluster 1638: conditions cardiac medical following affect impose study compliance opinion comorbid Cluster 1639: rbc red blood hemoglobin transfusions cell dl transfusion receive days Cluster 1640: bilirubin uln equal conjugated mla institutional needs level transaminases phase Cluster 1641: medically fit undergo stable patients physician determined inoperable unstable receive Cluster 1642: detection interstitial management suspected pulmonary toxicity lung interfere related symptomatic Cluster 1643: authorization release information health research written obtained use signed protected Cluster 1644: coronary artery disease cardiac symptomatic heart failure congestive myocardial infarction Cluster 1645: remain procedure able duration imaging hour minutes patient pet approximately Cluster 1646: participation study investigational clinical involving drug days weeks studies prior Cluster 1647: ejection left ventricular fraction cardiac rest function greater arrhythmias disease Cluster 1648: therapeutic weeks study participation drug treatment clinical molecule participated procedures Cluster 1649: hematologic hepatic renal function adequate cardiac coagulation inadequate defined poor Cluster 1650: aids hiv known illness related positive including infection history positivity Cluster 1651: protein serum dl electrophoresis monoclonal urine spep mg measurable immunofixation Cluster 1652: investigation participated clinical dosing investigational month currently drug prior patients Cluster 1653: partner female potential childbearing contraception use effective vasectomy agree men Cluster 1654: voluntarily understand sign informed consent form conducted assessments procedures document Cluster 1655: ibrutinib prior treatment therapy btk exposure investigational inhibitors previously patients Cluster 1656: effects surgery recovered major undergone starting weeks drug prior study Cluster 1657: bisphosphonate therapy bisphosphonates continue initiated receiving prior treatment patients allowed Cluster 1658: fertility future interested arm trial screening women fanca farber fap Cluster 1659: protected understand authorization information purpose risks ability provide health study Cluster 1660: daily prednisone equivalent mg corticosteroids immunosuppressive inhaled medications systemic condition Cluster 1661: expected patients survival weeks compliance non receive available study medical Cluster 1662: fraction liver shortening ejection portal capacity tlc approve pi supplementary Cluster 1663: performed albumin initiation dl mg days treatment hemoglobin registration dehydration Cluster 1664: grade sensory alopecia neuropathy persisting related toxicity constituting nci ctcae Cluster 1665: results interfere interpretation medical likely participation laboratory investigator history including Cluster 1666: cardiac heart significant arrhythmia myocardial failure infarction congestive disease clinically Cluster 1667: carcinomatosis leptomeningeal history cns metastases nervous lymphangitic brain central metastasis Cluster 1668: retinopathy retinal serous occlusion vein rvo csr central history current Cluster 1669: women employ unwilling nursing men contraception adequate childbearing potential pregnant Cluster 1670: corneal allograft transplant organ history including transplantation keratitis disease ulceration Cluster 1671: estimation creatinine gault cockcroft basis clearance min glomerular filtration ml Cluster 1672: interstitial lung evidence disease clinically history asymptomatic active patients dyspnea Cluster 1673: aml secondary therapy relapsed patients prior chemotherapy diagnosis related refractory Cluster 1674: protein hours urine mg level serum dl myeloma mm multiple Cluster 1675: hemolytic autoimmune anemia thrombocytopenia uncontrolled itp purpura idiopathic aiha immune Cluster 1676: conserving breast surgery mastectomy therapy radiation radiotherapy bcs patients undergo Cluster 1677: spoken english written understand language patient fluency proficient inability unable Cluster 1678: shorter half lives whichever days investigational dose drug study minimum Cluster 1679: unsupported platelets days transfusions hemoglobin mm count dl ul neutrophil Cluster 1680: feeding female breast pregnant patients lactating participants stop patient agree Cluster 1681: forced capacity fvc fev vital expiratory volume predicted second dlco Cluster 1682: substrates cypa narrow cypc therapeutic index sensitive cypd inhibitors strong Cluster 1683: msec qtcf ecg interval screening males females mean baseline electrocardiogram Cluster 1684: drugs investigational days received enrollment patient study use prior dose Cluster 1685: formulation components allergy hypersensitivity identified previously study subject treatment known Cluster 1686: substances inducers medications cypa inhibitors ineligible receiving strong patients cytochrome Cluster 1687: glycol polyethylene peg hypersensitivity polysorbate reactions growth allergic history excipients Cluster 1688: progressive massive thrombocytopenia lymphadenopathy evidence anemia splenomegaly lymphocytosis doubling symptomatic Cluster 1689: alanine aminotransferase alt upper limit normal times uln institutional age Cluster 1690: cr response complete pr achieved partial cri disease leukemia patients Cluster 1691: plasma leukemia cell circulating cells differential active amyloidosis standard diagnosis Cluster 1692: signs infection progressing attributable symptoms interpreted persisting infections hemodynamic sepsis Cluster 1693: entry study prior weeks days months patients time therapy received Cluster 1694: tb tuberculosis active excluded patients quantiferon ta latent test stages Cluster 1695: irradiated radiotherapy weeks better effects palliation recovered marrow bone received Cluster 1696: cardiac impaired function clinically significant diseases disease following including patients Cluster 1697: patient study investigator participate treatment disease medical therapy protocol unlikely Cluster 1698: nsclc stage iv iiib metastatic advanced diagnosis squamous treatment prior Cluster 1699: smoking cessation pack cigarettes history current year tobacco years smokers Cluster 1700: limits bilirubin normal upper total uln serum institutional times ast Cluster 1701: echocardiography ejection left fraction muga ventricular acquisition lvef gated scan Cluster 1702: hepatitis active known patients hepatic participants patient tuberculosis subject disorder Cluster 1703: avoid pregnancy fathering precautions appropriate children screening child agree certainty Cluster 1704: diabetes controlled poorly insulin patients history uncontrolled diabetic diagnosed oral Cluster 1705: splenectomy prior undergone history patients immunocompromised having allowed patient previous Cluster 1706: enrolled currently patients clinical trial study investigational trials protocol therapeutic Cluster 1707: superficial cancer bladder basal cell carcinoma squamous skin malignancy situ Cluster 1708: interventional agrees participate subject study treatment participant inclusion present randomization Cluster 1709: performance scale eastern cooperative ecog oncology group status karnofsky ps Cluster 1710: reactions allergic history attributed hypersensitivity patients compounds similar components paclitaxel Cluster 1711: live vaccine trial received dose days treatment prior run prohibited Cluster 1712: contraceptive use study agree potential effective methods method dose childbearing Cluster 1713: inclusive years age aged female male donor adult participants men Cluster 1714: percentile height th gender pressure age blood bp hypertension medication Cluster 1715: bleeding diathesis active evidence history patients known uncontrolled anticoagulation correctable Cluster 1716: paclitaxel nab carboplatin hypersensitivity known history cremophor arm weekly prior Cluster 1717: creatinine clearance hour urine min ml collection calculated serum measured Cluster 1718: guidelines according institutional informed consent signed obtained written assent local Cluster 1719: amino transferase uln alt ast aspartate alanine aminotransferase liver times Cluster 1720: strong inhibitors discontinued cypa inducers different switched treatment isoenzyme medication Cluster 1721: visits comply scheduled willing able procedures tests laboratory study schedule Cluster 1722: grade neuropathy fl pain hypertriglyceridemia edema peripheral ae hyperglycemia low Cluster 1723: negligible death metastasis malignancies risk outcome exception years expected curative Cluster 1724: initiation treatment study prior days weeks therapy investigational drug cancer Cluster 1725: block rhythm resting morphology degree important conduction abnormalities bundle branch Cluster 1726: ifn interferon immunostimulatory interleukin alpha il limited agents systemic cycle Cluster 1727: mm repeated accurately suitable accurate measurements axis longest irradiated lesion Cluster 1728: aortic vascular aneurysm dissection significant disease peripheral clinically history cardiac Cluster 1729: malignant disease non treated study tumor systemic preclude active treatment Cluster 1730: pulse room air oximetry oxygen saturation pulmonary dyspnea reserve level Cluster 1731: leukocytes mm ml registration obtained days prior cells equal phase Cluster 1732: pregnancy test miu negative sensitivity performed hours lenalidomide ip prior Cluster 1733: bilirubin origin rise hepatic gilberts syndrome unless non uln gilbert Cluster 1734: lesions endobronchial infiltrating vessels pulmonary major known bronchi hemorrhage increase Cluster 1735: extenuating circumstance significantly additional interfere opinion illness compliance condition medical Cluster 1736: inr desired anticoagulation anticoagulant recommended range level stable receiving normalized Cluster 1737: white blood count cell mm ul hydroxyurea cells mcl meet Cluster 1738: class heart association activity york disability ordinary new comfortable physical Cluster 1739: threshold seizure lower substituted medications discontinued known prior entry weeks Cluster 1740: cured carcinoma malignancy basal cervix years skin situ excised cell Cluster 1741: pik inhibitor mtor akt inhibitors treatment prior kinase rapamycin pathway Cluster 1742: recist measurable disease according lesion presence patients phase non site Cluster 1743: cycle day prior weeks days therapy treatment investigational chemotherapy anti Cluster 1744: active illness uncontrolled gastritis peptic diatheses including ulcer hepatitis pectoris Cluster 1745: phobia needed reasons examinations claustrophobia inability complete care standard imaging Cluster 1746: idiosyncrasy chemically delayed immediate reaction drugs hypersensitivity dmso related sulfoxide Cluster 1747: comorbidity index ci hct score hematopoietic age transplant cell years Cluster 1748: cbc blood count differential complete obtained registration function days prior Cluster 1749: significant clinically disease history uncontrolled metabolic heart immunosuppression medical study Cluster 1750: hamster chinese ovary produced biopharmaceuticals formulation atezolizumab hypersensitivity component cells Cluster 1751: coloproctitis hemorrhagic crohn diseases gastrointestinal colitis ulcerative irritable alter including Cluster 1752: chemotherapy allowable cancer different prior systemic note study therapy previous Cluster 1753: lipase pancreatitis radiologic clinical evidence uln upper limit normal cabozantinib Cluster 1754: times bilirubin upper limit normal uln serum institutional age range Cluster 1755: progenitor transplantation organ solid marrow bone allogeneic cell history prior Cluster 1756: heart classification york association new iii iv functional failure nyha Cluster 1757: androgen anti therapy receptor bicalutamide ar prior flutamide nilutamide generation Cluster 1758: risk condition pose investigator unacceptable place study opinion interfere patient Cluster 1759: follow return visits required assess obtain inability studies toxicity therapy Cluster 1760: gilbert bilirubin uln total syndrome unless documented disease serum patients Cluster 1761: state curative current therapy quality prolong survival known proven disease Cluster 1762: immunodeficiency hiv virus human infection negative history donor antibody patients Cluster 1763: hgb hemoglobin dl registration obtained days prior treatment study protocol Cluster 1764: measured measurable lesion accurately dimension mm ct disease defined mri Cluster 1765: haemoglobin dl transfused hb glycated hematology hbac haematological platelet anc Cluster 1766: familial sociological psychological geographical schedule potentially compliance follow protocol hamper Cluster 1767: cmv seropositive recipient antiviral infection donor cidofovir ganciclovir foscarnet seronegative Cluster 1768: hysterectomy prior undergone removal cervix simple having report women radical Cluster 1769: immunosuppressive therapy chronic systemic corticosteroids agents receiving treatment ongoing patients Cluster 1770: hct allogeneic autologous prior patients days post disease relapse cell Cluster 1771: asa anesthesiologists society american score status class anesthesiology physical iv Cluster 1772: invasive breast cancer bilateral diagnosis prior diagnosed history dcis non Cluster 1773: immunosuppressive medications systemic corticosteroids treatment weeks use prior requiring condition Cluster 1774: malignancies years free disease prior history unless study subject exception Cluster 1775: impaired cardiac function following including problems history protocol defined known Cluster 1776: illnesses antibiotics infections requiring disorders bleeding active fallopian falls false Cluster 1777: correctable supplements potassium range normal lln magnesium calcium limits corrected Cluster 1778: cgy radiation tbi therapy delivered prior patients centigray ineligible therapeutic Cluster 1779: plus duration instructions drug wocbp method treatment contraception follow study Cluster 1780: injected contraception implanted hormonal oral methods use established hormone transdermal Cluster 1781: feeding pregnancy breast test positive unwillingness women known urine effective Cluster 1782: renal creatinine function uln serum adequate times defined normal mg Cluster 1783: leukocyte hla antigen human positive donor identical patients related subtyping Cluster 1784: therapy days investigational anti neoplastic dose biologic prior agent chemotherapy Cluster 1785: wbc white ul blood cells cell count days counts obtained Cluster 1786: complications recovered adequately toxicity intervention major surgery starting prior therapy Cluster 1787: swog southwest oncology group performance status southwestern karnofsky zubrod eastern Cluster 1788: performing subject meeting prevent compromise study opinion requirements condition investigator Cluster 1789: ipsilateral breast radiation prior history cancer dcis previous therapy wall Cluster 1790: wocbp consecutive women months naturally postmenopausal menses hysterectomy undergone preceding Cluster 1791: inr ptt pt uln aptt normal coagulation limits upper patients Cluster 1792: radiographically measurable disease evaluable recist presence patients assessable clinically extranodal Cluster 1793: iodine contrast allergy radioactive intravenous history hypersensitivity materials iodide diet Cluster 1794: perforation gastrointestinal history fistula fistulae months ulceration bleeding gi prior Cluster 1795: randomization major surgery weeks prior days kyphoplasty date radiotherapy elapsed Cluster 1796: node sentinel axillary lymph dissection biopsy mastectomy lumpectomy surgery nodes Cluster 1797: fraction shortening ejection left ventricular fractional cardiac function cardiologist greater Cluster 1798: sensitivity known products components administered allergy derived dosing component ingredients Cluster 1799: study men duration agree contraception participation adequate pregnant use completion Cluster 1800: premedication steroids injection reactions articular intranasal corticosteroids inhaled hypersensitivity topical Cluster 1801: hypersensitivity used immediate agents reaction severe study history known previously Cluster 1802: turnstile ii infusion equal til inclusion chemotherapy criteria cell patients Cluster 1803: eligible brain metastases fewer radiosurgery stereotactic diameter asymptomatic month cm Cluster 1804: steroids prednisone mg equivalent day doses systemic topical dose steroid Cluster 1805: abdominal including dose treatment disorders fistula study filter abscess ischemic Cluster 1806: preclude oral illnesses absorption gastrointestinal olaparib medications able swallow cediranib Cluster 1807: mayo clinic return follow rochester willing willingness institution enrolling arizona Cluster 1808: unresolved toxicity common terminology ctcae adverse events alopecia grade cancer Cluster 1809: carfilzomib treatment prior bortezomib received therapy lenalidomide refractory dose days Cluster 1810: irinotecan prior topotecan hypersensitivity topoisomerase regimen containing treatment hydrochloride patients Cluster 1811: hc hepatitis positive hcab serology immunoblot riba reflexively test assay Cluster 1812: conditions medical interfere uncontrolled psychiatric treatment severe participation affect study Cluster 1813: ventricular pacemaker cardiac arrhythmias contractions medication requiring premature supraventricular pericarditis Cluster 1814: regimens chemotherapy prior number received disease patients metastatic treatment progressive Cluster 1815: rituximab containing prior therapy treatment months regimen refractory received dose Cluster 1816: trial clinical treatment participating trials participation participated patients investigational participate Cluster 1817: wocbp method nivolumab contraception half plus use pregnancy avoid lives Cluster 1818: sectional cross imaging disease ct metastatic cm scan tumor bone Cluster 1819: years chemotherapy cancer ages prior treatment completion entry post patients Cluster 1820: successful psychological compromise safety opinion unstable participation conditions medical investigator Cluster 1821: jeopardize compliance opinion condition protocol concurrent undesirable investigators investigator makes Cluster 1822: heart unstable cardiovascular angina york association new significant infarction myocardial Cluster 1823: heart york association infarction iii myocardial new iv class angina Cluster 1824: enteral malabsorption route condition syndrome precludes administration absorption interfere history Cluster 1825: dysfunction organ renal hepatic significant cardiac liver evidence history severe Cluster 1826: proteins murine allergy mouse hypersensitivity history known egg chimeric ige Cluster 1827: microliter count neutrophil absolute platelet anc mcl leukocyte equal randomization Cluster 1828: stage iii iv ii arbor ann disease cancer iva figo Cluster 1829: meeting criteria following disease measurable defined iwcll function adequate hematologic Cluster 1830: cell renal carcinoma clear rcc confirmed histologically component metastatic histological Cluster 1831: lab values performed creatinine uln surgeon results serum prior prevent Cluster 1832: platelet transfusion count days mm support ul prior weeks internal Cluster 1833: pugh child impairment hepatic classification according currently clinically significant class Cluster 1834: visit screening postmenopausal year months investigational prior weeks subjects days Cluster 1835: child bearing birth potential control women use study agree practice Cluster 1836: subarachnoid brain tia cva cerebrovascular stroke history accident hemorrhage attack Cluster 1837: mek inhibitor prior treatment kinase raf mitogen braf therapy activated Cluster 1838: treatments prior previous cancer discontinued patients weeks therapies received systemic Cluster 1839: initiation mcl neutrophil anc absolute count days performed treatment nabsolute Cluster 1840: calcium mg dl serum mmol corrected albumin adjusted hypercalcemia levels Cluster 1841: deficits neurologic stable week neurological minimum enrollment prior patients registration Cluster 1842: end stage renal disease liver dialysis kidney hemodialysis meld chronic Cluster 1843: unmanageable claustrophobia zydelig family farber fap fanconi fancd fancc fanca Cluster 1844: steroid immunosuppressive form excess chronic medication systemic doses replacement therapy Cluster 1845: live vaccine planned start received days study therapy virus medication Cluster 1846: female interruptions contact successful vasectomy abstinence condom sexual true undergone Cluster 1847: remission malignancy primary years history invasive second complete patients year Cluster 1848: significant infection clinically active requiring antibiotics virals fungals anti systemic Cluster 1849: braf mutation ve melanoma clia tumor raf oncogene mutations nras Cluster 1850: implants breast metal metallic bilateral patients mri contraindicated reconstruction women Cluster 1851: renal function adequate liver acceptable defined follows following cardiac days Cluster 1852: pneumonitis infectious steroids current required non history active known evidence Cluster 1853: cholesterol mg triglyceride dl fasting level serum total mmol levels Cluster 1854: despite hypertension uncontrolled medical optimal arterial management antihypertensive poorly controlled Cluster 1855: motor sensory neuropathy grade ctcae equal peripheral preexisting existing pre Cluster 1856: anticancer therapy investigational receipt treatment study systemic prior days drug Cluster 1857: creatinine hour clearance min ml serum uln hr cr institutional Cluster 1858: hcv rna hepatitis positive antibody negative ribonucleic acid pcr virus Cluster 1859: decitabine azacitidine hypomethylating treatment cycles prior agent therapy hma response Cluster 1860: toxicities receives recovered preparative grade elapsed weeks minor vitiligo patients Cluster 1861: communicate english able read spanish sensations exablate ability staff inability Cluster 1862: ecog patient screen enrolment better ii fanca farber fap fanconi Cluster 1863: fev expiratory forced volume second predicted pulmonary obstructive copd function Cluster 1864: plateau exhaustion volitional output exchange perceived exertion rpe hrmax power Cluster 1865: contained formulation excipient hypersensitivity drug known proteins recombinant tesirine rovalpituzumab Cluster 1866: cluster differentiation cd hiv count positive immunodeficiency virus cells human Cluster 1867: infarction myocardial cardiac months history prior entry stress study unstable Cluster 1868: myeloablative transplant conditioning stem months hematopoietic cell non allogeneic prior Cluster 1869: msec qtc corrected qt interval prolongation rate mean fridericia screening Cluster 1870: wocbp partners birth control fertile effective using men sexually sexual Cluster 1871: equal platelets greater mcl ul mm ctcae plts grade independent Cluster 1872: pyruvate glutamate sgpt transaminase alanine alt aminotransferase upper normal serum Cluster 1873: embolus deep thrombosis pulmonary vein history months venous patients enrollment Cluster 1874: leukemia chronic leukemias secretory burkitt accelerated myelogenous blast lymphocytic plasma Cluster 1875: radionuclide treatment dose weeks received study subject participant prior yttrium Cluster 1876: axis cm short diameter lymphadenopathy nodes lymph exceeding long node Cluster 1877: consent informed patients capacity willingness documented refuses assent subjects understand Cluster 1878: magnesium potassium normal calcium serum limits supplementation levels range sodium Cluster 1879: malignant tumors epithelial low borderline ovarian potential mullerian tumor mixed Cluster 1880: comply informed consent procedures written able provide study willing requirements Cluster 1881: refrain agreement abstinent remain donating sperm contraceptive measures men intercourse Cluster 1882: colorectal histologically confirmed cytologically metastatic adenocarcinoma cancer unresectable diagnosis patients Cluster 1883: resolution match donor typing drb hla dna high unrelated using Cluster 1884: gi gastrointestinal disease absorption interfere surgery history oral bleeding bleed Cluster 1885: hepatitis virus infection active known hiv evidence reactivation positive history Cluster 1886: metastasis brain patients radiation treated steroids untreated active asymptomatic stable Cluster 1887: hgb hemoglobin dl days anemia starting gr mg therapy treatment Cluster 1888: bmi kg mass index body obese overweight greater equal weight Cluster 1889: submission specimen tumor available tissue review patients specimens offered samples Cluster 1890: lactating period female pregnancy test positive screening serum patients breastfeeding Cluster 1891: beam external radiation therapy prior radiotherapy weeks received gy treatment Cluster 1892: rescue stem cell high chemotherapy dose autologous requiring previous transplant Cluster 1893: brain symptomatic metastases inclusive uncontrolled requiring corticosteroids limited concurrent radiation Cluster 1894: infection controlled antibiotics active eligible uncontrolled patients judged antimicrobial treatment Cluster 1895: radiological progression evidence disease amphotericin triazole clinical metastatic documentation receipt Cluster 1896: prohibited medications use medication current concomitant treatment study requires require Cluster 1897: blocks slides tissue notified unavailable sent chair enrollment study available Cluster 1898: compromise psychiatric interpretation participation study follow safety disorder interfere compliance Cluster 1899: dvt deep thrombosis embolism venous accident cerebrovascular attack transient pulmonary Cluster 1900: years gvhd ago allogeneic hematopoietic transplantation versus host symptoms undergone Cluster 1901: lie inability minutes flat scanning imaging pet entire ability supine Cluster 1902: rendering understanding altered prohibit mental dementia consent informed status psychiatric Cluster 1903: packed red blood transfusion prbc hemoglobin dl cell cells days Cluster 1904: birth control women potential effective men agree reproductive use childbearing Cluster 1905: parent guardian assent consent informed written patient legal signed minor Cluster 1906: ul lymphocyte count cycle day obtained days treatment study prior Cluster 1907: contralateral breast invasive cancer ipsilateral dcis synchronous previous history patients Cluster 1908: toxicities anticancer therapy previous unresolved recovered ctcae grade alopecia exception Cluster 1909: liver gallstones biliary disease asymptomatic gilbert exception chronic syndrome assessment Cluster 1910: immunocompromised hiv patients positive immunodeficiency virus human known antiretroviral currently Cluster 1911: matched donor unrelated related hla available donate mismatched allele suitable Cluster 1912: fluorescein allergy reaction known shellfish skin iodine test prior sodium Cluster 1913: lactating pregnant patients eligible participation practicing breastfeeding registration known ineligible Cluster 1914: acute chronic disease pancreatic skin severe infection liver renal infections Cluster 1915: length entire comply designee procedures understand study enrolling ability determined Cluster 1916: dermatitis atopic cohort skin exfoliative epidermis patients disrupts psoriasis subjects Cluster 1917: potentially curative amenable therapy patients disease standard resection available extending Cluster 1918: airway enlargement obstruction location cause tumor lymphodepletion procurement exclusion fixed Cluster 1919: untreated brain metastases symptomatic known require symptoms control treated meningeal Cluster 1920: benefit clinical confer therapies intolerant provide known available treatment refractory Cluster 1921: medi receipt dose anticancer prior days investigational therapy amp weeks Cluster 1922: antifungal antiviral infection antibiotic requiring active antibiotics systemic therapy agents Cluster 1923: stage disease clinical patients ib iiia bclc ii ia cancer Cluster 1924: addictive preclude psychiatric disorders meeting conditions requirements opinion patient investigator Cluster 1925: brain radiation therapy prior radiosurgery stereotactic metastases treatment wbrt radiotherapy Cluster 1926: iuln bilirubin total registration direct patients days prior arm cohort Cluster 1927: iuln aminotransferase ast alt aspartate alanine liver metastases registration days Cluster 1928: speak english able understand comprehend ability patients unable informed consent Cluster 1929: context ancillary investigation utilized fda indication research food approved immunotherapy Cluster 1930: old years patients patient female male adult time donor women Cluster 1931: transaminase iuln aminotransferase serum glutamic sgot oxaloacetic glutamate pyruvate sgpt Cluster 1932: hbv hepatitis dna positive negative viral hbsag surface virus antibody Cluster 1933: healed wound surgery fully major incision weeks surgical enrollment incompletely Cluster 1934: dysfunction adrenal pituitary history documented malignancy known viral liver symptomatic Cluster 1935: adequately cell basal treated squamous skin malignancy carcinoma cancer years Cluster 1936: pills swallow inability unwillingness fall fap fanconi fancd fancc fanca Cluster 1937: substantially increase judgment risk associated participation investigator condition illness major Cluster 1938: therapy steroid immunosuppressive form trial immunodeficiency diagnosis systemic receiving dose Cluster 1939: lln magnesium serum potassium calcium sodium lower lvef fibrinogen institutional Cluster 1940: meet criteria following inclusion patients laboratory subjects eligible study exclusion Cluster 1941: spinal cord compression tumor evidence cauda imminent brainstem impending radiation Cluster 1942: hcv hepatitis hbv virus positive rna surface antigen antibody acid Cluster 1943: cdk inhibitor prior treatment received therapy patient inhibitors patients previous Cluster 1944: smoker current cigarettes daily self smoking day ex smoked pack Cluster 1945: birth control potential childbearing agree pregnancy study use test method Cluster 1946: aged female male years subjects patients equal greater inclusive age Cluster 1947: metformin taking hypersensitivity reason insulin diabetic currently known subjects patients Cluster 1948: bleeding dose heparin molecular weight inr stable carries warfarin low Cluster 1949: protection partners barrier birth control method willing week childbearing principal Cluster 1950: strong inhibitor cypa cytochrome treatment require ibrutinib continuous dose gp Cluster 1951: corticosteroid use systemic prednisone therapy dose chronic mg prior condition Cluster 1952: oximetry pulse room air infusion inclusion patients treatment previously radiation Cluster 1953: total bilirubin serum uln institutional days initiation grade performed treatment Cluster 1954: curatively carcinoma treated malignancy situ skin basal cell years squamous Cluster 1955: fetal precautions counseled risks pregnancy exposure agree minimum contact days Cluster 1956: telephone access number address reached working research engage nurse functioning Cluster 1957: eso ny expression ihc immunohistochemistry tumor positive rt immunotherapeutics pcr Cluster 1958: adenocarcinoma carcinoma epithelial cell endometrioid serous histologic undifferentiated clear mixed Cluster 1959: diatheses uncontrolled bleeding active including severe diseases hepatitis systemic evidence Cluster 1960: methods accepted medically sexually contraception fertile male female partners agree Cluster 1961: ugta polymorphism homozygous udp diclofenac imipramine glucuronosyltransferase inhibitor ketoconazole mefenamic Cluster 1962: castrate testosterone ng dl level levels nmol prostate serum resistant Cluster 1963: creatinine normal age patients clearance grade biopsy renal serum prior Cluster 1964: estimated glomerular filtration rate egfr min ml creatinine renal cockcroft Cluster 1965: amyloidosis al primary known systemic non patients diagnosis myeloma complicated Cluster 1966: ability written provide informed consent willingness comply judged protocol investigator Cluster 1967: myopathy history chronic donor rhabdomyolysis steroid existing simvastatin patients pre Cluster 1968: apply criteria inclusion additional information contact investigator exclusions unable pembrolizumab Cluster 1969: nitrosoureas weeks mitomycin chemotherapy prior study radiotherapy therapy entering patients Cluster 1970: magnesium lower limit normal mg dl supplementation serum level lln Cluster 1971: chemotherapy received prior patients radiation therapy cancer radiotherapy previous adjuvant Cluster 1972: dose prednisone corticosteroids steroids adrenal equivalent insufficiency chronic mg rheumatoid Cluster 1973: thallium restrictive comparable stress obstructive respiratory illnesses coagulation active pulmonary Cluster 1974: psa progression bone pcwg prostate disease lesions new defined scan Cluster 1975: metastases brain known participants excluded patients corticosteroids treated imaging clinical Cluster 1976: qt cardiac heart ventricular coronary history screening block significant left Cluster 1977: nervous central cns disease active malignancy patients history known primary Cluster 1978: uncontrolled hepatitis heart severe chronic congestive symptomatic disease quantifiable cardiac Cluster 1979: administration institutional upper limit normal uln measured total bilirubin days Cluster 1980: claustrophobia severe anxiolytics unresponsive inability history scanning tolerate oral symptomatic Cluster 1981: degrees febrile fahrenheit unexplained temperature celsius illness infection requiring active Cluster 1982: compression cord spinal brain metastases stable unless asymptomatic steroids treatment Cluster 1983: antiarrhythmic unstable tachycardia pacemaker block class temporary indwelling cardiac qt Cluster 1984: zubrod eastern oncology cooperative ecog group status performance level karnofsky Cluster 1985: marrow bone aspirate biopsy peripheral blood patients days performed prior Cluster 1986: qtcf ecg triplicate mean screening msec correction ecgs interval fridericia Cluster 1987: tumors solid advanced patients malignant metastatic subjects eligible excluded cell Cluster 1988: live virus vaccination contain flu seasonal planned vaccines start received Cluster 1989: bowel small condition modify study enzymes pancreas inappropriate interpretation make Cluster 1990: transfusion platelets independent mm platelet days support mcl prior ul Cluster 1991: initiating prior treatment therapy days study protocol weeks systemic estrogens Cluster 1992: uln liver alt metastases alanine present aminotransferase metastasis transaminase ast Cluster 1993: proton pump inhibitors histamine antacids antagonists ppis use receptor study Cluster 1994: blockers beta arrhythmic digoxin anti cardiac arrhythmias requiring channel therapy Cluster 1995: amyloid light amyloidosis chain al involvement systemic stain known primary Cluster 1996: british french fab american promyelocytic leukemia classification aml acute mds Cluster 1997: composition chemical compounds attributed similar reactions allergic biologic used agents Cluster 1998: aim phase sub ii prisoners protocol type outpatient cancer evaluation Cluster 1999: exist additional criteria exclusion inclusion regarding morbid restrictions illness disease Cluster 2000: hypertensive anti controlled hypertension pressure blood medications patients history mmhg Cluster 2001: neuroendocrine prostate adenocarcinoma differentiation features cell histologically small confirmed cytologically Cluster 2002: gi alter significantly impairment absorption function gastrointestinal disease panobinostat everolimus Cluster 2003: optic nerve chiasm glioma pathway apparatus nf tumor patients medulla Cluster 2004: female participants subjects patients years breastfeeding patient prefer whichever method Cluster 2005: heart uncontrolled electrocardiographic conduction ischemia relevant ecg medically abnormalities abnormality Cluster 2006: heparin low flush acetylsalicylic dwelling dose anticoagulation acid needed maintenance Cluster 2007: cetuximab panitumumab treatment prior egfr antibody infusion therapy hypersensitivity monoclonal Cluster 2008: threatening life infection uncontrolled active disease untreated patients antimicrobial severe Cluster 2009: urine proteinuria random sample protein ratio hrs measured persistent grade Cluster 2010: seizure disorder medication requiring history uncontrolled patients controlled active neurologic Cluster 2011: daratumumab cd anti therapies received previously prior cluster sy differentiation Cluster 2012: vomiting nausea preclude absorption bowel refractory significant resection malabsorption adequate Cluster 2013: concurrent therapy treatment protocol allowed cancer use radiation permitted investigational Cluster 2014: past days investigational therapy use tobacco received receiving smoke herbal Cluster 2015: normal upper alt limit ast uln institution range donor institutional Cluster 2016: affecting significantly gastrointestinal function malabsorption swallow syndrome unable disease capsules Cluster 2017: visits scheduled tests comply willingness procedures plans ability laboratory study Cluster 2018: filgrastim support neutrophil absolute mm count greater anc equal gcsf Cluster 2019: organ undue kidney involving dysfunction place disease undergo risk concurrent Cluster 2020: measurable assessed disease ct registration days prior documented non tomography Cluster 2021: organ marrow function adequate defined requirements follows subjects patient protocol Cluster 2022: palliative radiation radiotherapy weeks therapy prior treatment study allowed days Cluster 2023: phenobarbital carbamazepine phenytoin wort rifabutin inducers st cypa rifampin johns Cluster 2024: lymphoma pr cr initial nhl eligible mantle cell lymphoplasmacytic prolymphocytic Cluster 2025: triglycerides fasting mg dl hypertriglyceridemia cholesterol uncontrolled equal mmol serum Cluster 2026: upc protein urine ratio hour creatinine dipstick proteinuria value assessed Cluster 2027: olaparib hypersensitivity excipients product known patients tremelimumab cabazitaxel composition chemical Cluster 2028: pregnant study inform suspect immediately participating woman barrier birth physician Cluster 2029: return enrolling institution follow willing willingness site alliance study operative Cluster 2030: carcinomas malignancies basal squamous skin cell treated adequately years past Cluster 2031: transplant marrow bone stem cell autologous allogeneic prior rescue previous Cluster 2032: adverse events ctcae terminology common grade criteria recovered prior alopecia Cluster 2033: plt ul platelets registration days obtained transfusion thrombocytopenia prior sgn Cluster 2034: regorafenib prior use treatment criteria sunitinib inclusion tas patients exclusion Cluster 2035: transplantation allogeneic organ marrow bone prior solid patients allograft autologous Cluster 2036: avoidance producing measures child agree male contraception potential female use Cluster 2037: abdominal bowel obstruction perforation abscess intra diverticulitis gastrointestinal carcinomatosis factors Cluster 2038: performing evaluations authorization procedures obtained written hipaa related protocol screening Cluster 2039: pre registration criteria exclusion eligibility chemotherapy procedure initiated final met Cluster 2040: sgot oxaloacetic glutamic transaminase aspartate aminotransferase ast upper limit normal Cluster 2041: angina new heart onset months cardiac rest anginal nyha infarction Cluster 2042: bilirubin total gilbert normal syndrome upper mg dl limit institutional Cluster 2043: cerebrospinal fluid csf cns nervous central involvement cytology leptomeningeal lymphoma Cluster 2044: treatment malignancy required years systemic start evidence subject study past Cluster 2045: ckit favorable karyotype mutated cr remission npm mutation inv risk Cluster 2046: remains cavity prior portion abdominal localized pelvis head neck years Cluster 2047: mri undergo unable contrast patients inability brain able scan imaging Cluster 2048: equal greater neutrophil absolute count anc mm mcl ul creatinine Cluster 2049: deteriorate hypo hyperthyroid autoimmune psoriasis vitiligo disease diabetes type requiring Cluster 2050: grades pain neuropathy significant grade days prior enrollment randomization day Cluster 2051: immunodeficiency acquired aids syndrome virus hiv human related illness known Cluster 2052: ischemic attack transient stroke months history prior day thrombosis tia Cluster 2053: adults years age older old unable infants individuals consent aged Cluster 2054: thrombocytopenia heparin induced history platelets known platelet coagulopathy drug complications Cluster 2055: dyspnea rest intrinsic resulting lung evidence lungs extensive exertion involvement Cluster 2056: cardiac disease arrhythmia history shunts patients known condition active requiring Cluster 2057: crisis myelogenous leukemia blast chronic intolerant failed phase bcr abl Cluster 2058: ribociclib pdr fulvestrant cohort dose prior expansion treatment run long Cluster 2059: breast cancer prior diagnosed therapy history treatment radiation patients recurrent Cluster 2060: withstand compromise organ major ability disease therapy patients chair discussed Cluster 2061: disease syndrome inflammatory celiac hashimoto systemic following consultation diet patients Cluster 2062: marginal zone splenic lymphoma nodal extranodal mzl malt mucosa follicular Cluster 2063: try final study administration agree pregnant drug days heterosexually months Cluster 2064: fluency english verbal data collection completion adequate lack caregiver patient Cluster 2065: infections fungal bacterial viral active uncontrolled unresponsive infection patients therapy Cluster 2066: vitamin warfarin antagonists concomitant use supplementation antagonist iu patients day Cluster 2067: lansky score karnofsky performance years patients inclusion scores greater adults Cluster 2068: metastasis nervous central cns symptomatic known malignancy untreated history active Cluster 2069: care medical consent prejudice voluntary withdrawn future understanding given procedure Cluster 2070: immunotherapy chemotherapy prior weeks therapy radiation treatment received patients study Cluster 2071: carcinoma cell basal malignancy situ skin squamous cervix years treated Cluster 2072: jeopardize reasonable outlined safety ability receive illness infection concurrent medical Cluster 2073: males females age years aged older time old consent greater Cluster 2074: mother breastfeeding discontinued pregnant treated women excluded study agents apply Cluster 2075: leukapheresis prior undergo donor weeks chemotherapeutic cladribine lymphotoxic contraindications agents Cluster 2076: bone metastases scan disease metastasis metastatic imaging lesions paget skeletal Cluster 2077: reason complicates participate interferes opinion investigator undue patient data interpretation Cluster 2078: sirolimus temsirolimus everolimus hypersensitivity rapamycins known excipients analogs rapamycin intolerance Cluster 2079: antibiotic requiring infection active therapy systemic infections intravenous treatment iv Cluster 2080: pap intraepithelial smear cancer situ cervical localized remission curatively squamous Cluster 2081: moderate cypa strong inducers inhibitors use days dose study prior Cluster 2082: sarcoidosis syndrome history fcg fascia fap fanconi fancd fancc fanca Cluster 2083: unwilling comply unable protocol patients requirements study procedures assessed investigator Cluster 2084: grade enter anticancer toxicities alopecia ctcae therapies recovered related version Cluster 2085: adherence interfere opinion ability condition investigators clinically medical protocol significant Cluster 2086: individuals contact immunocompromised household avoid eczemoid eczema vaccination close nursing Cluster 2087: risk high intermediate patients disease neuroblastoma following defined factors criteria Cluster 2088: hepatitis pcr positive antibody polymerase chain antigen reaction surface core Cluster 2089: infections active clinically patients antibiotics evidence hepatitis known grade controlled Cluster 2090: mcl platelet count cells thrombocytosis pi days transfused marrow mm Cluster 2091: interventional study clinical observational enrollment concurrent follow studies participation unless Cluster 2092: therapy steroid immunosuppressive form receiving systemic immunodeficiency diagnosis days prior Cluster 2093: copy probe signals number average cep ihc ratio ish dual Cluster 2094: procedures minor surgical placement major days port surgery biopsy waiting Cluster 2095: warfarin use therapeutic anticoagulants concurrent thrombolytic requires current requiring condition Cluster 2096: malignancy considered currently active relapse completed second melanoma skin risk Cluster 2097: resected completely cell basal squamous skin carcinoma exceptions situ recurred Cluster 2098: lower normal values calcium magnesium potassium limit lab institution phosphorus Cluster 2099: sibling donor hla matched identical offspring parent transplant available haploidentical Cluster 2100: hbac ac hemoglobin glucose diabetes glycated mellitus fasting poorly controlled Cluster 2101: expectancy life weeks patients severely limited diseases year malignancy days Cluster 2102: scheduled surgery undergo receive patients chemotherapy cancer study patient procedure Cluster 2103: equal platelet greater count mm mcl transfusion ul support turnstile Cluster 2104: breastfeeding women excluded pregnant discontinued study prior nursing avoided treatment Cluster 2105: agent investigational registration days treatment prior therapy protocol registered study Cluster 2106: cytologically advanced histologically locally metastatic confirmed unresectable adenocarcinoma documented nsclc Cluster 2107: ancillary considered bisphosphonates supportive therapy concurrent allowed care investigational note Cluster 2108: female pregnant breastfeeding patients ineligible subjects eligible intends study actively Cluster 2109: colorectal cancer metastatic chemotherapy patients crc diagnosed prior stage breast Cluster 2110: additional progressing malignancy requires known active treatment years required past Cluster 2111: product participation clinical investigational study weeks days receipt months prior Cluster 2112: integrity tract malabsorption gastrointestinal lack physical syndrome upper oral unable Cluster 2113: toxicity exacerbated reasonably irreversible expected unresolved hearing included ctcae grade Cluster 2114: hbv hcv virus hepatitis infection cleared known hiv chronic immunodeficiency Cluster 2115: transfusion hemoglobin dl permitted days blood prior administration past preceding Cluster 2116: received prior therapy patients treatment radiation eligible weeks dose study Cluster 2117: diameter lymph axis node mm short lesion measurable longest recist Cluster 2118: deprivation androgen therapy prior adt prostate months orchiectomy cancer patients Cluster 2119: distress respiratory syndrome thermometer patients severe nccn comprehensive network hypertension Cluster 2120: abnormalities laboratory following cardiac significant ecg baseline history chemistry hematologic Cluster 2121: malignancy active secondary relapse uncontrolled patients treatment treated transplant requires Cluster 2122: marrow transplantation bone stem cell prior allogeneic hematopoietic reserves extensive Cluster 2123: sgpt purpose transaminase pyruvate uln glutamate alt alanine aminotransferase serum Cluster 2124: version solid recist response evaluation tumors measurable criteria disease defined Cluster 2125: brain metastases excluded trial clinical known patients participants untreated symptomatic Cluster 2126: calcium corrected serum normal uln albumin phosphate institutional hypercalcemia levels Cluster 2127: avastin bevacizumab received prior weeks treatment therapy use scheduled planned Cluster 2128: major surgery weeks planned study prior elective course starting treatment Cluster 2129: kps score ci hct aged greater modified definitions rpa patients Cluster 2130: weight lbs scanner pounds table weighing limit fit gantry pet Cluster 2131: seizure consciousness loss brain arteriovenous malformation attack transient ischemic history Cluster 2132: swallowing difficulty capsules malabsorption capable hamper participate procedures absorption willing Cluster 2133: albumin mg dl supplementation serum intravenous day cycle days hypercalcemia Cluster 2134: measurable neuroblastoma lesions mibg disease fluid detected gallium bone collections Cluster 2135: intrauterine iud ius device placement releasing hormone established progestin systems Cluster 2136: gut dysphagia ingestion short gastroparesis orally syndrome absorption administered gastrointestinal Cluster 2137: functions adequate renal organ marrow bone liver hepatic defined hematological Cluster 2138: measurable disease defined following patients imaging non evaluable radiologically irrecist Cluster 2139: radiotherapy prior days chemotherapy treatment brain received previous cranial dose Cluster 2140: age years lansky corresponding scores ecog patients eastern cooperative oncology Cluster 2141: tissue tumor needle specimens core biopsy samples paraffin acceptable slides Cluster 2142: incarcerated prisoners involuntarily subjects individuals patients persons likely person participants Cluster 2143: growth anc mm neutrophil absolute factor count support days factors Cluster 2144: open traumatic injury biopsy major significant procedure surgical days start Cluster 2145: absorption gastrointestinal disorder affecting gastrectomy interfere rucaparib peptic opinion investigator Cluster 2146: times uln bilirubin total liver creatinine metastases serum ast alt Cluster 2147: heart pressure mmhg blood uncontrolled systolic hypertension diastolic myocardial infarction Cluster 2148: currently agents investigational receiving vaccines received weeks patients previous tumor Cluster 2149: fulvestrant treatment prior combination endocrine cohort therapy received study dose Cluster 2150: tumors primary brain cns nervous central patients metastases solid seizures Cluster 2151: corticosteroids systemic patients receiving weeks dose treatment prior replacement days Cluster 2152: irb iec board ethics approved review consent committee informed independent Cluster 2153: hemolysis gilberts bilirubin syndrome unless mg total dl hyperbilirubinemia normal Cluster 2154: escalation dose cohort expansion phase patients enrolled stage combination portion Cluster 2155: survival estimated months probability gpa median month patients year weeks Cluster 2156: phase ib expansion portion treatment patients prior study eligibility trial Cluster 2157: flow angiographic maa duodenum technetium macroaggregated tc stop application detectable Cluster 2158: wocbp contraceptive contraception effective highly pregnancy heterosexually continuously exempt active Cluster 2159: threatening dysfunction safety compromise outcomes organ life undue illness opinion Cluster 2160: supratentorial tumor location remote brain compartment elective craniotomy glioma evidence Cluster 2161: pose safety risk opinion consulted condition disorder amgen interfere investigator Cluster 2162: month entry investigational therapy study prior patients treatment antitumor neoplastic Cluster 2163: virus htlv human lymphotropic hiv immunodeficiency cell infection seropositive leukemia Cluster 2164: mental compromise comply impairment ability requirements informed consent study deficits Cluster 2165: docetaxel prior treatment chemotherapy cabazitaxel prostate sensitive cancer received metastatic Cluster 2166: responsive accepted care relapse progressive therapy curative standard non surgery Cluster 2167: gvhd host versus graft disease acute active grade ii chronic Cluster 2168: curative intent surgery treatment resection radiation treated disease surgical therapy Cluster 2169: bsa area body surface level dose patients mg enrolled cover Cluster 2170: radiotherapy start weeks treatment prior study palliative received therapy radiation Cluster 2171: liver portal hypertension varices biliary hepatic esophageal fulminant encephalopathy hepatitis Cluster 2172: retinal detachment macular degeneration degenerative history vein ophthalmologic occlusion neurosensory Cluster 2173: competent mentally consent informed sign understand form willingness ability irb Cluster 2174: dose treatment study radiation days therapy received bone metastasis site Cluster 2175: ability medication oral swallow dosage impaired receive patients form solid Cluster 2176: neurologically stable metastases brain treated cns nervous central steroids corticosteroids Cluster 2177: threatening illness unrelated life cancer opinion psychiatric potentially medical interfere Cluster 2178: alcoholism addiction confuse hinder illness psychiatric follow evaluation drug active Cluster 2179: liver function adequate defined acceptable demonstrated subjects normal bilirubin participant Cluster 2180: receptor negative ihc er pr progesterone estrogen immunohistochemistry hybridization fish Cluster 2181: psychological medical condition compliance investigator compromise participation social opinion study Cluster 2182: bleeding active risk high pathologic disorder carry major coagulopathy conditions Cluster 2183: severe hepatic impairment moderate disease cirrhosis cardiovascular renal existing pre Cluster 2184: qtc family history long syndrome personal ventricular prolongation bigeminy msec Cluster 2185: cns epileptic inducing involvement enzyme completion stable tumor receiving metastases Cluster 2186: apply exclusion criteria inclusion cohort additional hepatitis chronic infection active Cluster 2187: procedure surgical major cranial anticipation traumatic open injury need course Cluster 2188: evaluable recist measurable disease criteria non according version lesion patients Cluster 2189: surgery prior days patients weeks planned definitive undergo breast patient Cluster 2190: acute exercise uncontrolled pulmonary cardiopulmonary failure dissecting myocarditis hemodynamic aggravated Cluster 2191: ventricular atrial heart tachycardia degree fibrillation block lvef arrhythmias old Cluster 2192: neuropathy terminology common ctcae events adverse peripheral criteria grade existing Cluster 2193: sterile surgically documented postmenopausal effective month contraception hysterectomy screening post Cluster 2194: proteinuria dipstick urine protein urinalysis hours hour discovered demonstrate collection Cluster 2195: cabozantinib prior treatment dose days dl albumin platelets obtained hemoglobin Cluster 2196: flow cytometry cd expression marrow immunohistochemistry cells bone peripheral blood Cluster 2197: pathology national nci institute cancer laboratory confirmation confirmed diagnosis metastatic Cluster 2198: distant metastasis evidence lymph induction organs liver bone clavicles patients Cluster 2199: contraception methods oophorectomy child highly women bearing effective intrauterine appropriate Cluster 2200: strong cypa inducers inhibitors treatment concomitant requires study medications cytochrome Cluster 2201: liver alcoholic fatty inherited cirrhosis disease viral hepatitis significant clinically Cluster 2202: creatine phosphokinase ck cpk uln kinase plasma normal upper limit Cluster 2203: hiv authority mandated health testing local unless immunodeficiency virus required Cluster 2204: medi phase cohort ii eligibility cancer criteria study ovarian colorectal Cluster 2205: hypersensitivity known drugs thalidomide study agents analogs allergy anaphylactic patients Cluster 2206: brain remained metastases patients stable carcinomatous meningitis trial excluded metastatic Cluster 2207: surgery major placement minor access vascular weeks excluding study procedures Cluster 2208: diarrhea grade chronic ctcae gastrointestinal persistent patients malabsorption etiology symptom Cluster 2209: hepatocellular carcinoma hcc cholangiocarcinoma diagnosis fibrolamellar liver confirmed mixed histologically Cluster 2210: dialysis renal patients requiring currently failure creatinine mg contrast dl Cluster 2211: carcinoma situ cured cervical skin malignancies ductal melanomatous invasive non Cluster 2212: nursing excluded pregnant women study patients step following included woman Cluster 2213: major procedure surgical anticipation traumatic injury need course open significant Cluster 2214: estimated cockcroft gault creatinine clearance min ml cc serum equal Cluster 2215: weight loss months past program unintentional body prior watchers experienced Cluster 2216: aes events adverse alopecia grade recovered baseline prior anticancer resolved Cluster 2217: concomitant medications therapy use protocol systemic malignancies study disorder uncontrolled Cluster 2218: gilberts bilirubin upper uln normal total limit syndrome unless disease Cluster 2219: breastfeeding women lactating study participants eligible registration time zydelig fancd Cluster 2220: total bilirubin normal direct dl mg age elevated check conjugated Cluster 2221: idelalisib prior treatment arm exposure pik mfolfox zydelig resistance exclusion Cluster 2222: endothelial vegf growth vascular factor vegfr bevacizumab receptor prior anti Cluster 2223: formulations allergy components hypersensitivity identified previously component study known cobimetinib Cluster 2224: alk egfr ros mutation nsclc rearrangement mutations patients translocation approved Cluster 2225: intravascular disseminated coagulation dic leukostasis evidence cns bleeding leukemia uncontrolled Cluster 2226: start major surgery weeks study treatment prior recovery days complete Cluster 2227: transaminase serum sgot pyruvate glutamate glutamic sgpt oxaloacetic normal upper Cluster 2228: directly staff member spouse immediate involved sponsor family site prospective Cluster 2229: herbal palmetto saw supplements medications psa products decrease use alternative Cluster 2230: neck head cancer patients primary dissection diagnosis tumor lung recurrent Cluster 2231: whichever longer half lives drug investigational study days dose weeks Cluster 2232: morbidities active clinically disease significant compromise pulmonary uncontrolled participation condition Cluster 2233: antihypertensive bp pressure medications blood mmhg change controlled adequately week Cluster 2234: females pregnancy test negative childbearing potential serum urine days prior Cluster 2235: time inr ptt thromboplastin normalized partial ratio international prothrombin pt Cluster 2236: agent investigational type dose received days treatment study subject drug Cluster 2237: bpm beats rate minute heart bradycardia hr resting ecg screening Cluster 2238: eligibility criteria infusion lymphodepletion tvs ctl meet proceed phase specific Cluster 2239: microl count absolute equal neutrophil greater platelets platelet registration anc Cluster 2240: curable apparently cured cancers locally malignancy cancer years previous superficial Cluster 2241: concurrently investigational receiving agents study patients drug days treatment participation Cluster 2242: fibrosis colitis pneumonitis inflammatory bowel pulmonary disease known history chronic Cluster 2243: parameters laboratory range protocol defined adequate acceptable meet medical following Cluster 2244: ambulatory walking non assistive aid walk able ecog devices self Cluster 2245: void volume residual bladder post ml fanca fap fanconi fancd Cluster 2246: pt time anticoagulant intended anticoagulants prothrombin ptt inr range normalized Cluster 2247: cll sll iwcll treatment diagnosis therapy prior criteria patients received Cluster 2248: lvef left ejection fraction ventricular cardiac known improve symptomatic rest Cluster 2249: allow compromise disorder compliance psychiatric appropriate does protocol consent informed Cluster 2250: psa doubling time months psadt values patients calculate measurements dt Cluster 2251: pregnancy test positive women serum administration enrollment product wocbp urine Cluster 2252: immunotherapy radiotherapy chemotherapy investigational therapy agents treatment prior days concurrent Cluster 2253: uncontrolled disorder prohibits medical obtaining examples cava vena superior poor Cluster 2254: nature benefits willingly alternatives risks aware informed discomforts experimental neoplastic Cluster 2255: spread threatening visceral term life short symptomatic complications risk advanced Cluster 2256: pre registration inclusion criteria optional tissue secondary days post cystectomy Cluster 2257: illness infection active medical intercurrent psychiatric including uncontrolled patients concurrent Cluster 2258: infection requiring drug completed systemic recent dose days treatment study Cluster 2259: currently receiving treatment therapy patients chemotherapy patient radiation medications neoplastic Cluster 2260: uncontrolled concurrent significant compromise clinically medical severe participation neurological pulmonary Cluster 2261: waldenstrm macroglobulinemia wm lymphoplasmacytoid lpl lymphoma lymphocytic secretory stated criteria Cluster 2262: lymphoblastic leukemia lymphoma acute cell patients precursor burkitt diagnosis relapsed Cluster 2263: resolved institute terminology national common grade version ctcae nci cancer Cluster 2264: lymphedema group treatment edema neck head cancer iii therapists primary Cluster 2265: regulatory received indication approval drug nonmyelosuppressive days myelosuppressive treatment respectively Cluster 2266: transponders anchored mr artifact imaging image monitored safe lung tumors Cluster 2267: intent treated curative carcinoma malignancy years situ cell basal skin Cluster 2268: impair study opinion participation investigator medical uncontrolled disorder increase associated Cluster 2269: members ethnic races groups eligible trial men included women minorities Cluster 2270: contraception childbearing women potential men adequate use agree practice study Cluster 2271: anticoagulation therapeutic receiving patients therapy anticoagulant aspirin require anticoagulants stable Cluster 2272: sampling blood suitable access venous required study pk serial marrow Cluster 2273: complete questionnaires able english quality study baseline willing forms assessment Cluster 2274: classes excipients formulations hypersensitivity study drugs allergy suspected given drug Cluster 2275: product investigational days medicinal prior received treatment weeks administration study Cluster 2276: hampering sociological geographical familial psychological schedule potentially follow compliance protocol Cluster 2277: coumarin derivative anticoagulation therapeutic warfarin coumadin anticoagulants derivatives mg po Cluster 2278: cardiovascular history conditions disease evidence risk following uncontrolled unstable current Cluster 2279: inr warfarin heparin normalized ratio international stable ptt time thromboplastin Cluster 2280: albumin serum hypersensitivity calcium abnormal range corrected normal concentration lln Cluster 2281: advanced histologically locally metastatic confirmed unresectable solid proven adenocarcinoma patients Cluster 2282: eastern cooperative oncology ecog group performance status patient randomization grade Cluster 2283: preclude disorder participation medical outlined uncontrolled psychiatric active geographic adherence Cluster 2284: flc serum light mg chain abnormal protein involved ratio free Cluster 2285: gilbert mg dl bilirubin syndrome total unless hemolysis disease known Cluster 2286: birth control intrauterine device iud methods pills use potential contraceptive Cluster 2287: cirrhosis alcohol viral abuse liver clinically hepatitis significant including current Cluster 2288: metastasis alkaline phosphatase liver present bone absence upper limit normal Cluster 2289: heart congestive myocardial failure infarction months unstable angina history cardiac Cluster 2290: attack ischemic transient cerebrovascular accident tia cva history months prior Cluster 2291: fungal mycobacterial nail beds antibiotics infection infections excluding bacterial episode Cluster 2292: blast count hydroxyurea peripheral circulating blood marrow counts ul mm Cluster 2293: melanoma skin non malignancy cancer years treated cancers exception active Cluster 2294: acidosis lactic metabolic history metformin associated risk meq alcoholic beverages Cluster 2295: marrow bone function adequate defined evidenced subject lymphodepleting patient participants Cluster 2296: childs cirrhosis pugh class score liver severe hepatic known disease Cluster 2297: antibiotics infection requiring active iv systemic chronic study suppressive weeks Cluster 2298: hepatitis virus immunodeficiency human hiv infection known active chronic history Cluster 2299: ventricular heart significant fibrillation failure myocardial infarction tachycardia association york Cluster 2300: transplantation organ history allogenic stem prior including cell major liver Cluster 2301: aspartate ast aminotransferase normal upper limit uln transaminase limits registration Cluster 2302: malignancies active concurrent expectant observation killer patients natural requiring history Cluster 2303: final contraception method partner sexually effective product childbearing nonsterilized potential Cluster 2304: significant disease interpretation affect diseases pulmonary uncontrolled concomitant results compliance Cluster 2305: tablets swallow ability oral retain difficulty acetate abiraterone patients tolerate Cluster 2306: conventional therapy chemotherapy radiation curable weeks patients tumor disease treatment Cluster 2307: incision larger involves percutaneous anesthesia general tube access placement venous Cluster 2308: transplant host versus graft allogeneic stem gvhd cell disease active Cluster 2309: serology hepatitis positive cirrhosis fibrosis liver chronic stage infection active Cluster 2310: richter transformation prolymphocytic leukemia cll syndrome lymphocytic dlbcl confirmed lymphoma Cluster 2311: objectives compromise opinion investigator condition study medical protocol nonmalignant sponsor Cluster 2312: formula estimated creatinine gault clearance ml cockcroft min cockroft using Cluster 2313: cirrhosis liver hepatic known ascites history chronic evidence disease meaningful Cluster 2314: coagulopathy bleeding disorder uncontrolled uncorrectable known existing history disorders patients Cluster 2315: bleomycin prior treatment radiosurgery chemotherapy use enrollment contraindicates morbid agent Cluster 2316: pyruvate sgpt glutamate transaminase alt alanine aminotransferase serum uln institutional Cluster 2317: effects recovered surgery radiotherapy prior recent antineoplastic patients therapy chemotherapy Cluster 2318: pelvic abdominal irradiation previous radiation brachytherapy prostate prior received vaginal Cluster 2319: excretion metabolism distribution absorption interfere gastrointestinal significantly disease condition presence Cluster 2320: cancers melanoma non malignancies skin years situ active hematologic patients Cluster 2321: nursing pregnancy infant mother donor patients females active women excluded Cluster 2322: markedly acuity decreased visual macular degeneration glaucoma uncontrolled patients causes Cluster 2323: gammopathy significance undetermined monoclonal smoldering mgus myeloma multiple amyloidosis macroglobulinemia Cluster 2324: neoadjuvant adjuvant chemotherapy prior therapy months setting received metastatic treatment Cluster 2325: persons unwilling nursing employ contraception adequate potential pregnant following childbearing Cluster 2326: antibody monoclonal lives half elapsed dose prior antibodies treatment days Cluster 2327: dexamethasone mg dose day equivalent days daily prior corticosteroid systemic Cluster 2328: delirium memorial scale assessment rating cognitive score hours mixed cognition Cluster 2329: hepatic function adequate encephalopathy defined follows evidenced history dysfunction met Cluster 2330: exclude opinion investigator subject presence following study enrollment patient patients Cluster 2331: lymphocyte count mcl mm absolute days total equal enrollment blood Cluster 2332: donors donor marrow blood related meet apheresis unrelated nmdp guidelines Cluster 2333: bradycardia resting significant symptomatic beats clinically minute medically baseline pacemaker Cluster 2334: legal representative consent informed able written provide patient understand sign Cluster 2335: malignancy years history past prior previous active evidence exceptions diagnosed Cluster 2336: confound results study situation subject condition significantly participation risk opinion Cluster 2337: hearing loss grade impairment sensorineural existing significant cisplatin patients clinically Cluster 2338: history disease known prior patients glaucoma heart oxalate urethral stricture Cluster 2339: guardian unwillingness legal representative research inability participant written consent informed Cluster 2340: kind immediate palliative requirement surgery including treatment zydelig fanca fap Cluster 2341: ischemia evidence symptomatic peripheral myocardial ecg cardiac arrhythmia significant muscle Cluster 2342: mesothelioma pleural malignant peritoneal histologically mpm confirmed pemetrexed cytologically unresectable Cluster 2343: toxicity related grade returned prior therapy baseline irreversible deemed persisting Cluster 2344: illness psychiatric medical compliance significant consent informed prevents severe mental Cluster 2345: highly effective method birth sexually control women potential childbearing trial Cluster 2346: cd cells expression cell positive prior cll tumor diagnosis car Cluster 2347: bearing child potential contraception use women effective agree study men Cluster 2348: immunosuppressant cyclosporine tacrolimus systemic days concurrent prednisone drug dose chronic Cluster 2349: step randomization prior registration ii days criteria dl enrollment hemoglobin Cluster 2350: sex having condom woman use drug study pregnant agrees dose Cluster 2351: sign willingness form understand ability consent informed written study initiation Cluster 2352: albumin initiation dl mg days treatment cohort sbrt noted determined Cluster 2353: medication immunosuppressive prior use current days dose systemic treatment exceptions Cluster 2354: pancreatic cancer prior chemotherapy treatment radiation metastatic therapy patients radiotherapy Cluster 2355: beta pregnancy pregnant subject established hcg chorionic result confirmation gonadotropin Cluster 2356: transfused hemoglobin dl hgb patients meet level value criterion days Cluster 2357: involvement nervous cns central known lymphoma patients intrathecal refractory aml Cluster 2358: potent cypa inducers inhibitors use medications stop known supplements receiving Cluster 2359: situ carcinoma cervix breast cis uteri bladder adequately history treated Cluster 2360: advanced cancer metastatic breast diagnosis therapy disease prior received solid Cluster 2361: second malignancy active currently requiring years primary cancer concurrent treatment Cluster 2362: incomplete healing surgery wound injuries major treatment recovery planned study Cluster 2363: block bundle branch left complete bifascicular right hemiblock anterior lbbb Cluster 2364: isolated palliative intent local lesions surgery acceptable major procedure surgical Cluster 2365: neuropathy grade baseline patients ctcae significant neurosensory time diabetic enrollment Cluster 2366: signed written informed consent provide provided irb subjects study approved Cluster 2367: denosumab bisphosphonates treatment rankl activator started bone patients atezolizumab ligand Cluster 2368: concurrent chemotherapy radiation allowed therapy receiving patients immunotherapy cytotoxic biologic Cluster 2369: childbearing effective potential contraception women agreement forms use partners men Cluster 2370: tegretol inducers equetro epitol phenytek rifadin dilantin luminal carbatrol provigil Cluster 2371: investigational drug days treatment study prior dose received enrollment use Cluster 2372: pectoris angina unstable uncontrolled requiring known arrhythmia medication subjects months Cluster 2373: recover reversible effects fully regardless failure acute interval prior chemotherapy Cluster 2374: evaluable disease patients imaging metastatic response phase presence lesion evidence Cluster 2375: birth control use effective study agree adequate acceptable forms form Cluster 2376: anticancer therapies currently receiving therapy received chemotherapy weeks radiation start Cluster 2377: amylase pancreatitis lipase history increased pancreatic symptoms uln cholecystitis suggestive Cluster 2378: uncontrolled lung active severe conditions uncompensated parenchymal diatheses disease renal Cluster 2379: fluent english spanish aim phase language speakers inclusion caregiver pcs Cluster 2380: glucose fasting mmol plasma mg dl fpg hbac diabetes type Cluster 2381: heart class iv iii failure york association new nyha congestive Cluster 2382: cord umbilical blood transplant marrow double bone units transplantation donor Cluster 2383: exclusionary weeks diagnostic node resolved lymph discontinued effects adverse radiation Cluster 2384: cmv vaccine investigational anti time prior agent received activity recipient Cluster 2385: myelogenous leukemia chronic cml acute aml phase accelerated patients crisis Cluster 2386: bacterial fungal viral requiring systemic active infection uncontrolled therapy infections Cluster 2387: nervous central metastatic options disease available therapeutic radiotherapy including fanca Cluster 2388: illness uncontrolled compliance requirements study limit social inter psychiatric situations Cluster 2389: impair ability underlying condition medical receive patient protocol infection treatment Cluster 2390: lesions inactive considered cns asymptomatic active treated nervous central small Cluster 2391: voluntary written consent informed donor research related aspects procedures comply Cluster 2392: cfr code donor regulations federal eligibility agency outlined donation guidance Cluster 2393: situ carcinoma definitively cervix squamous basal melanoma skin malignancy cell Cluster 2394: jeopardize safety condition compliance unstable patient subject study investigator medical Cluster 2395: ctla therapies targeted pd excluded prior pdl stimulatory targeting checkpoint Cluster 2396: measure psa reference nd rising days value taken rises initial Cluster 2397: unwilling unable consent informed sign form document written patients icd Cluster 2398: randomization days prior radiotherapy surgery chemotherapy therapy participant radiation date Cluster 2399: survival likely concomitant associated year illness fanca fap fanconi fancd Cluster 2400: visits follow willing able attend study comply travel protocol nih Cluster 2401: murine products hypersensitivity containing protein reactions history allergy bovine known Cluster 2402: autoimmune disease systemic requires steroids immunosuppressive syndrome agents documented history Cluster 2403: hepatitis hepatology patient consultation profile discussed benefit eligibility require determined Cluster 2404: candidate surgical patient surgery appropriate surgeon resection medical deemed curative Cluster 2405: illness compliance intercurrent situations uncontrolled social requirements psychiatric limited limit Cluster 2406: volunteers healthy cohorts normal enhancement sub patient contrast group adult Cluster 2407: childbearing correctly potential consistently use highly agreement partners rate continue Cluster 2408: unresectable metastatic disease melanoma patients inoperable confirmed histologically tumor advanced Cluster 2409: virus hepatitis htlv human lymphotropic hiv antibody immunodeficiency donor hcv Cluster 2410: tissue tumor available biopsy archived research provide fresh testing patients Cluster 2411: aminotransferase uln obtained aspartate alanine ast alt registration days prior Cluster 2412: bcg intravesical induction months disease calmette cis guerin doses prior Cluster 2413: endocrine therapy breast cancer prior adjuvant chemotherapy metastatic treatment received Cluster 2414: fast maintain mln hours hour oral administration medication required able Cluster 2415: permissible cavity melanomatous invasive free cervix minimum situ oral malignancy Cluster 2416: allergies known drug intolerance subjects classes separate history vaccine adhesives Cluster 2417: valproic acid deacetylase hdac histone panobinostat prior patients treatment need Cluster 2418: dehydration grade nci ctcae exacerbated ctc version conditions common opinion Cluster 2419: axitinib prior bosutinib studied treatment population thrombotic hypersensitivity parts ended Cluster 2420: cigarettes smoke tobacco products day use past smoked nicotine cigars Cluster 2421: torsade pointes factors history hypokalemia risk family qt long additional Cluster 2422: existing pre interstitial lung disease known cardiovascular carotid ild liver Cluster 2423: noninfectious pneumonitis interstitial evidence lung history active steroids required disease Cluster 2424: qt qtc msec syndrome long corrected interval congenital history fridericia Cluster 2425: carcinoma appropriately melanoma treated malignancy skin uterine situ non cervix Cluster 2426: histologically breast confirmed invasive cancer cytologically primary diagnosis metastatic subtypes Cluster 2427: cns cerebellar disorder dementia ischemia hemorrhage cerebrovascular disease autoimmune involvement Cluster 2428: dental oral jaw extraction surgery healed tooth planned procedures invasive Cluster 2429: accountability portability insurance act hipaa health consent informed authorization written Cluster 2430: undergo willing biopsy biopsies tumor willingness treatment able pre research Cluster 2431: disorders bleeding psychiatric history known patients neurological thrombotic major significant Cluster 2432: oophorectomy appropriate bearing child considered potential vasomotor spontaneous amenorrhea profile Cluster 2433: bear beget children agreement sexually able study contraception dose use Cluster 2434: alcohol abuse drug known history active suspected illicit months investigator Cluster 2435: laboratory clia improvement certified clinical amendments mutation act results tumor Cluster 2436: crcl creatinine gault cockcroft clearance formula ml min using calculated Cluster 2437: oxaliplatin irinotecan fluoropyrimidine fluorouracil fu leucovorin bevacizumab capecitabine chemotherapy therapy Cluster 2438: provide written able consent informed patients guardian patient study registration Cluster 2439: oxygen supplemental requiring requirement daily continuous patients saturation use therapy Cluster 2440: consecutive undergone childbearing potential orientation months naturally meets sexual regardless Cluster 2441: institute national nci common grade ctcae version adverse cancer events Cluster 2442: transaminase aminotransferase serum glutamic oxaloacetic pyruvate sgot glutamate sgpt ast Cluster 2443: hrt cessation menopausal estradiol female hormone fsh year value experienced Cluster 2444: bilirubin uln gilbert total direct syndrome normal patients range serum Cluster 2445: bp mmhg diastolic hypertension pressure systolic blood uncontrolled medication despite Cluster 2446: hepatitis indicating virus acute positive chronic test infection result known Cluster 2447: kettering sloan memorial mskcc center cancer confirmed msk diagnosis pathology Cluster 2448: standard therapy advanced refractory solid available metastatic histologically tumors tumor Cluster 2449: older male female years age patients participants subjects consent time Cluster 2450: allergy suspected agent given trial known course sorafenib association investigational Cluster 2451: checkpoint immune inhibitor inhibitors prior therapy treatment blockade immunotherapy therapies Cluster 2452: allergens allergic unknown severe reactions components history drugs vaccines anaphylaxis Cluster 2453: atrial fibrillation arrhythmia cardiac controlled uncontrolled arrhythmias history requiring flutter Cluster 2454: azd structure similar inactive excipients chemical osimertinib drugs hypersensitivity class Cluster 2455: conforms federal consent guidelines approved institutional form provide signed able Cluster 2456: prolonging torsade relative switched inducing pointes qt different interval medications Cluster 2457: allo hsct sct hct post cell gvhd stem transplant allogeneic Cluster 2458: women childbearing potential amenorrhea possibly amenorrheic bilateral months suppression antiestrogens Cluster 2459: ribose poly adp parp polymerase inhibitor adenosine diphosphate prior treatment Cluster 2460: karnofsky ecog poor health rating index screening time false fancc Cluster 2461: women pregnant planning nursing participate study eligible breastfeed ineligible donor Cluster 2462: sleep apnea sleepiness daytime excessive obstructive syndrome result supplemental conditions Cluster 2463: involvement cns nervous central active known malignancy leukemia leptomeningeal lymphoma Cluster 2464: provided consent informed written subject study procedures activities participate prior Cluster 2465: immunodeficiency hiv virus human positive known patients status serologically individuals Cluster 2466: compliant initiative investigator means protocol patient opinion proximity team study Cluster 2467: hepatitis polymerase chain reaction pcr positive active infection antiviral antigen Cluster 2468: primary disease patients refractory myelofibrosis cancer invasion history endometrial tumor Cluster 2469: cancers primary active skin requiring patients systemic treatment second cured Cluster 2470: remains received chemotherapy prior localized pelvic adjuvant years abdominal cancer Cluster 2471: hemoglobin level dl reached transfusion eligibility gm days achieve registration Cluster 2472: physician treating determined opinion discretion patients deemed medical judged treatment Cluster 2473: durvalumab tremelimumab dose female days monotherapy reproductive effective birth employ Cluster 2474: antibody anti hama mouse human ctla prior murine titer elisa Cluster 2475: cdk cyclin dependent kinase inhibitor prior treatment received therapy previously Cluster 2476: unwilling women stopping use reproductive intercourse men vasectomy effective having Cluster 2477: parenteral antibiotics infection requiring active infective requires oral ongoing current Cluster 2478: scr creatinine ccr renal serum clearance min ml upper limit Cluster 2479: corticosteroids sprays drops applications airways eye articular uses rash obstructive Cluster 2480: evidence leukemic cns active involvement definitively meningeal cerebral disease nervous Cluster 2481: hsct autologous amg start treatment weeks prior alemtuzumab admission allogeneic Cluster 2482: dtpa gadolinium known gd acid reaction allergic dimeglumine anaphylactic acetic Cluster 2483: coumadin warfarin anticoagulants derivative anticoagulant doses sodium therapeutic patients taking Cluster 2484: radioisotope gfr creatinine glomerular filtration min clearance rate ml serum Cluster 2485: predominant lymphocyte nodular hodgkin lymphoma hl classical hodgkins rich diagnosis Cluster 2486: radiation marrow bone therapy prior received weeks pelvis patients hematopoietically Cluster 2487: pneumonitis infectious interstitial non lung steroids required history disease evidence Cluster 2488: cell basal skin carcinoma squamous malignancy cancer years malignancies active Cluster 2489: keeping anderson aware policies nature center consent md indicating investigational Cluster 2490: gleason score biopsy prostate cores higher cancer pattern grade core Cluster 2491: threatening life potentially autoimmune active disease second activated patients history Cluster 2492: toxic effects recovered therapy prior grade acute alopecia chemotherapy fully Cluster 2493: steroids deficiencies stress necessary endocrine physiologic doses receive allowed patients Cluster 2494: methylation mgmt polymerase chain reaction pcr routinely status quantitative available Cluster 2495: cr subsequent leukemias biphenotypic undifferentiated lymphoma leukemia burkitts nd prolymphocytic Cluster 2496: heart nyha controlled abnormalities york association arrhythmia infarction myocardial congestive Cluster 2497: infective illnesses coagulation infections active disorders major medical systemic requiring Cluster 2498: emergency surgery room requiring leukapheresis radiation needs hyperleukocytosis undergoing procedure Cluster 2499: participants agents investigational receiving stratum study days cancer treatment received