Karnofsky performance status >= 60 within 21 days prior to study entry Karnofsky performance status >= 60% Karnofsky performance status >= 60% TUMOR BIOPSY SEQUENCING: Karnofsky performance status >= 70% TREATMENT: Karnofsky performance status >= 70% Karnofsky performance status >= 70 within 28 days prior to step 2 registration Karnofsky performance status >= 70% Karnofsky performance status of >= 70 within 28 days prior to Step 2 registration ECOG performance status =< 2 (Karnofsky >= 60 %) Karnofsky performance status >= 60% Karnofsky performance status >= 60 Karnofsky performance score >= 70 Karnofsky performance status >= 60 History and physical exam, and Karnofsky performance status of >= 70 within 30 days prior to registration