Patients with a history of toxic epidermal necrolysis (TEN) or Stevens-Johnson syndrome are excluded Patients with Down syndrome Active or a history of Tourette�s syndrome or tic disorder No history of Steven�s Johnson�s syndrome, toxic epidermal necrolysis (TEN)s syndrome, or motor neuropathy Patients with Down syndrome are not eligible Diagnosis of Down syndrome (Trisomy 21) Patients must not have known Gilbert�s syndrome No known Gilbert�s syndrome or known homozygosity for UGAT1A1*28 polymorphism Patients with Down syndrome Down syndrome Patients with down syndrome are excluded from this study