History of allergic reactions attributed to compounds of similar chemical or biologic composition to lenalidomide (i.e. thalidomide) History of allergic reactions attributed to compounds of similar chemical or biologic composition to vorinostat History of allergic reactions attributed to compounds of similar chemical or biologic composition to romidepsin, including cyclic tetrapeptide compounds History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN8237, bortezomib or rituximab History of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD6244 History of allergic reactions attributed to compounds of similar chemical or biologic composition to cabozantinib (XL184) Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide or AZD1775 (MK-1775) are ineligible; the AZD1775 (MK-1775) investigator brochure and the temozolomide package insert can be referenced for more information History of allergic reactions attributed to compounds of similar chemical or biologic composition to TRC102 or TMZ History of allergic reactions attributed to compounds of similar chemical or biologic composition to XL184 History of allergic reactions attributed to compounds of similar chemical or biologic composition to CYT107 Patients with history of allergic reactions attributed to compounds of similar chemical or biologic composition to belinostat, including hydroxamate compounds or arginine Known severe hypersensitivity to selumetinib or any excipient of selumetinib or history of allergic reactions attributed to compounds of similar chemical or biologic composition to selumetinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to navitoclax, dabrafenib, or trametinib, or excipients or to dimethyl sulfoxide (DMSO) History of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD 1775 (MK-1775) or gemcitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to study drugs History of allergic reactions attributed to compounds of similar chemical or biologic composition to study drugs; patients who have previously received either clofarabine or bortezomib will be excluded Prior allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine (gemcitabine hydrochloride) or cisplatin Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN0128 (TAK-228) are ineligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to navitoclax or sorafenib History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN0128 (TAK-228) or ziv-aflibercept History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN0128 or bevacizumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to cabozantinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to MK-3475 and ziv-aflibercept History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to afatinib and/or cetuximab History of allergic reactions attributed to compounds of similar chemical or biologic composition to GDC-0449 History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN0128 (TAK-228) History of allergic reactions attributed to compounds of similar chemical or biologic composition to TRC102 or pemetrexed and cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD1775 or belinostat History of allergic reactions attributed to compounds of similar chemical or biologic composition to IPdR Patient must NOT have a history of allergic reaction attributable to compounds of similar chemical or biologic composition to 18F-fluorothymidine Patient must NOT have a history of allergic reaction attributable to compounds of similar chemical or biologic composition to 18F-FES Known severe hypersensitivity to selumetinib or any excipient of selumetinib or history of allergic reactions attributed to compounds of similar chemical or biologic composition to selumetinib Prior allergic reactions attributed to other monoclonal antibodies History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN0128 (TAK-228) Patients must NOT have a history of allergic reactions attributed to compounds of similar chemical or biochemical composition to cisplatin, carboplatin, etoposide, temozolomide or capecitabine Known sensitivity to or history of allergic reactions attributed to compounds of similar chemical or biologic composition entinostat, nivolumab, or ipilimumab; history of severe hypersensitivity reaction to any monoclonal antibody Patient does not have a known allergy to compounds of similar or biologic composition as triapine History of clinically significant allergic reactions attributed to compounds of similar chemical or biologic composition to AT13387 or paclitaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN0128 (TAK-228) History of allergic reactions attributed to compounds of similar chemical or biologic composition to onalespib or AT7519M History of hypersensitivity attributed to compounds of similar chemical or biologic composition to MLN0128 (TAK-228) or osimertinib (AZD9291) History of allergic reactions attributed to compounds of similar chemical or biologic composition to MEDI-570 or history of anaphylaxis to any biological component History of allergic reactions attributed to compounds of similar chemical or biologic composition to methoxyamine or to pemetrexed or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib and/or onalespib History of allergic reactions attributed to compounds of similar chemical or biologic composition to VX-970, cisplatin, or gemcitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to M6620 (VX-970) or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to AT13387 (onalespib) History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib (difficulty breathing, lip swelling, itching or rash) History of allergic reactions attributed to compounds of similar chemical or biologic composition to VX-970 History of allergic reactions attributed to compounds of similar chemical or biologic composition to MK-3475 (pembrolizumab) History of allergic reactions attributed to compounds of similar chemical or biologic composition to triapine or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to M6620 (VX-970) or gemcitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to VX-970 or irinotecan Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to VX-970, carboplatin, gemcitabine or to these specific compounds History of allergic reactions attributed to compounds of similar chemical or biologic composition to veliparib and MM-398; if patients have a history of allergic reactions to compounds resembling MM-398, they will be excluded from participating in the FMX MRI study, if applicable History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to nelfinavir Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to LY2606368 or to its formulation are not eligible Known severe hypersensitivity to selumetinib or any excipient of selumetinib or history of allergic reactions attributed to compounds of similar chemical or biologic composition to selumetinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab, ipilimumab, or blinatumomab History of allergic reactions attributed to compounds of similar chemical or biologic composition to tremelimumab and MEDI4736 or previous toxicity attributed to MEDI4736 or other PD-1 or PD-L1 directed therapy that led to drug discontinuation Patients with a history of allergic reactions attributed to compounds of similar composition, including macrolide and ketolide antibiotics, temsirolimus/other mTOR inhibitors, temozolomide or irinotecan are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab or atezolizumab Known hypersensitivity to MK-3475 (pembrolizumab) or history of allergic reactions to compounds of similar chemical or biologic composition to anti-PD1 or PD-L1 antibodies or entinostat History of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD9291 (osimertinib) or bevacizumab Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to BAL101553 are ineligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to IPdR Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to PT2385 are ineligible