Alkaline phosphatase =< 2.5 x ULN (CTCAE v 3.0 grade 0-1) Alkaline phosphatase within upper limits of institutional normal within 14 days prior to study entry Alkaline phosphatase less than or equal to 2.5 x ULN (CTCAE grade 1) Alkaline phosphatase =< 3 x ULN Alkaline phosphatase =< 1.5 x IULN within 28 days prior to registration Serum alkaline phosphatase (ALP) > 2 x ULN Alkaline phosphatase less than or equal to 2.5 x ULN Alkaline phosphatase =< 1.5 x institutional ULN, within 21 days prior to registration Alkaline phosphatase (ALP) =< 2.5 x ULN measured within 28 days prior to randomization Patients must have alkaline phosphatase =< 2.5 x IULN within 14 days prior to registration Alkaline phosphatase =< 2 x ULN (=< 5 x ULN for patients with known liver involvement and =< 7 x ULN for patients with known bone involvement) Alkaline phosphatase =< 2 x ULN (=< 5 x ULN for patients with known liver involvement and =< 7 x ULN for patients with known bone involvement) Within 6 weeks prior to randomization: Alkaline phosphatase must be =< 2.5 x ULN for the lab Alkaline phosphatase =< 2.5 x ULN, within 14 days prior to registration Alkaline phosphatase must be =< 3 x ULN for the lab within 28 days before randomization Alkaline phosphatase =< 2.5 x ULN (=< 5 x ULN for patients with documented liver involvement or bone metastases) Alkaline phosphatase =< 2 x IULN Alkaline phosphatase =< 2.5 x ULN (=< 5 x ULN for patients with documented liver involvement or bone metastases) Alkaline phosphatase =< 2.5 x ULN Alkaline phosphatase =< 2.5 x ULN Alkaline phosphatase =< 2.5 x IULN, obtained within 28 days prior to step 2 registration Alkaline phosphatase =< 2 x ULN (=< 5 x ULN for patients with documented liver involvement or bone metastases)