Total bilirubin =< 1.5 x upper limit of normal (ULN) Total bilirubin =< 1.5 x the upper limit of normal (ULN) Total bilirubin < 2 x institutional upper limit of normal (ULN) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) obtained =< 21 days prior to registration Total serum bilirubin =< 1.5 times upper limit of normal (ULN) (=< grade 1); if total bilirubin is 2 to 3 mg/dL, but direct bilirubin is normal, then the patient will be considered eligible Bilirubin less than or equal to 1.5 x upper limit of normal (ULN) (CTCAE grade 1) Total bilirubin =< 5 x upper limit of normal (ULN) Total bilirubin < 1.5 x upper limit of normal assessed within seven (7) days prior to the start of therapy Bilirubin =< 3.0 x upper limit of normal (ULN) Total bilirubin =< 1.5 x upper limit of normal (ULN) TREATMENT: Bilirubin =< 2 x upper limit of normal Bilirubin < 1.5 times institutional upper limit of normal, within 21 days prior to study entry Total bilirubin =< 1.5 institutional upper limit of normal (ULN) Obtained =< 7 days prior to registration: Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) Serum bilirubin > 1.5 x upper limit of normal (ULN) Total bilirubin =< 1.5 times upper limit of normal (ULN) Total bilirubin < 2 x the institutional upper limit of normal (ULN) Total bilirubin < 2 x institutional upper limit of normal (ULN) within 14 days prior to registration Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) Total bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin < 1.5 x upper limit of normal (ULN) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) Total bilirubin =< 1.5 within 30 days prior to registration* It is highly recommended but not required that total bilirubin be =< 1.5 upper limit of normal Total bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin less than or equal to 1.5 x institutional/laboratory upper limit of normal (ULN) Bilirubin =< 1.5 times upper limit of normal Total bilirubin =< 1.5 x institutional upper limit of normal (ULN), within 21 days prior to registration Bilirubin =< 1.5 x upper limit of normal (ULN) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) Total bilirubin > 2 times the upper limit of normal Total bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin =< 1.5 upper limit of normal (ULN) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (or =< 2.5 x upper limit of normal [ULN] with Gilbert�s syndrome) Total bilirubin =< 1.5 x upper limit of normal (ULN) Total bilirubin =< 1.5 x upper limit of normal (ULN) Total bilirubin =< 1.5 x upper limit of normal (ULN) Total bilirubin =< 1.5 times institutional upper limit of normal (ULN) INCLUSION CRITERIA FOR STRATUM C: Total bilirubin =< 1.5 times institutional upper limit of normal (ULN) Total bilirubin =< 1.5 � upper limit of normal (ULN) for the laboratory unless resulting from hemolysis Total bilirubin =< institutional upper limit of normal (ULN) or =< 1.5 X institutional ULN (if the patient has liver metastases) Total bilirubin within =< 1.5 times the upper limit of normal (ULN) institutional limits Total bilirubin less than or equal to the institution's upper limit of normal Total bilirubin =< 1.5 x the institutional upper limit of normal (ULN) Total bilirubin < 1.5 upper limit of normal (ULN) Total bilirubin =< 1.5 x upper limit of normal (ULN) Total bilirubin =< the upper limit of normal (ULN) within 4 weeks prior to randomization RECURRENT/ PROGRESSIVE DIPG (STRATUM 1): Total bilirubin =< 1.5 times institutional upper limit of normal (ULN) NON-PROGRESSED DIPG (STRATUM 2): Total bilirubin =< 1.5 times institutional upper limit of normal (ULN) Total bilirubin below normal institutional upper limit of normal (ULN) Bilirubin =< 1.5 x upper limit of normal (ULN), within 14 days prior to registration Total bilirubin =< 1.5 times institutional upper limit of normal (ULN) Within 28 days prior to administration of study treatment: Total bilirubin =< 1.5 x the institutional upper limit of normal (ULN) Within less than or equal to 14 days prior to registration: Total serum bilirubin =< institutional upper limit of normal (ULN) Within 28 days prior to administration of therapy: Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) Total bilirubin < 4 x institutional upper limit of normal (ULN) Bilirubin =< 1.5 upper limit of normal (ULN)