Treatment with any other investigational agent within 4 weeks prior to cycle 1, day 1 Treatment with any other investigational agent within 4 weeks prior to cycle 1, day 1 Treatment with any other investigational agent within 4 weeks prior to cycle 1, day 1 Patients who have received any other investigational agents within the past 28 days prior to cycle 1 day 1 Treatment with any other investigational agent within 4 weeks prior to cycle 1, day 1 Treatment with any other investigational agent within 4 weeks prior to cycle 1, day 1