Patient�s current disease state must be one for which there is no known curative therapy or therapy proven to prolong survival with an acceptable quality of life Therapeutic options: patient�s current disease state must be one for which there is no known curative therapy or therapy proven to prolong survival with an acceptable quality of life Patient�s current disease state must be one for which there is no known curative therapy or therapy proven to prolong survival with an acceptable quality of life Patient�s current disease state must be one for which there is no known curative therapy or therapy proven to prolong survival with an acceptable quality of life Patient�s current disease state must be one for which there is no known curative therapy or therapy proven to prolong survival with an acceptable quality of life Patient�s current disease state must be one for which there is no known curative therapy or therapy proven to prolong survival with an acceptable quality of life Patient�s current disease state must be one for which there is no known curative therapy or therapy proven to prolong survival with an acceptable quality of life Patient�s current disease state must be one for which there is no known curative therapy