Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; however, HIV-positive patients without an acquired immune deficiency syndrome (AIDS)-defining diagnosis who are not receiving agents with the potential for pharmacokinetic (PK) interactions with ABT-888 may be eligible Known human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are not eligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Known human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Known human immunodeficiency virus (HIV) or other history of immunodeficiency disorder; HIV-positive patients on combination antiretroviral therapy are ineligible HIV-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible HIV-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV) positive patients on antiretroviral therapy are ineligible TREATMENT: HIV-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; it is not necessary to conduct HIV testing at screening; patients who are HIV-positive with undetectable viral loads, not on interacting antiretroviral therapy, and have CD4 counts above 300/mm^3 may be eligible after discussion with the principal investigator HIV-positive patients on combination antiretroviral therapy are ineligible Patients known to be human immunodeficiency virus (HIV)-positive patients and on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible HIV-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Patients who are known to have human immunodeficiency virus (HIV) or are on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Patients who are known to have human immunodeficiency virus (HIV) or are on combination antiretroviral therapy are ineligible Patient does not have known human immunodeficiency virus syndrome (HIV, testing optional); known HIV-positive patients receiving combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy known to interact with CYP isoenzymes are ineligible; in addition, HIV patients with CD4 count < 200 cells/uL are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Patients with human immunodeficiency virus (HIV) on antiretroviral therapy are ineligible Patients who are known to be human immunodeficiency positive (HIV)-positive and are on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated Human immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; patients must also have a CD4 count > 350 cells/mm^3 with an undetectable viral load Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated Human immunodeficiency virus (HIV)-positive patients are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are INELIGIBLE Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible due to potential drug-drug interactions with PT2385