Cluster 0: obstruction bowel signs symptoms starting drugs history month current study Cluster 1: received prior patients treatment days therapy study chemotherapy dose previously Cluster 2: study pregnant contraception agree participation adequate duration men women use Cluster 3: patients prior study eligible disease patient history treatment days registration Cluster 4: consent informed signed sign dated form written patient institutional guidelines Cluster 5: platelets microliters plt dependent study day transfusion dose weeks treatment Cluster 6: composition compounds similar attributed chemical allergic reactions biologic used agents Cluster 7: karnofsky eastern cooperative ecog performance group oncology status kps greater Cluster 8: neutrophil absolute count mm microliters cells randomization enrollment weeks days Cluster 9: transfusion hemoglobin dl days blood past enrollment prior administration preceding Cluster 10: platelet count mm days registration randomization prior mcl obtained ml Cluster 11: limits normal institutional creatinine upper bilirubin days uln registration serum Cluster 12: iuln bilirubin total upper registration institutional limit normal days prior Cluster 13: mother breastfeeding discontinued treated pregnant excluded women study vx mln Cluster 14: transaminase aminotransferase uln serum ast glutamic alt liver sgot sgpt Cluster 15: absolute neutrophil mcl count growth hematopoietic factors days prior ul Cluster 16: illness uncontrolled compliance social situations psychiatric intercurrent pectoris requirements arrhythmia Cluster 17: expectancy life greater months weeks appropriate patient estimated sequencing equal Cluster 18: solid marrow tumors bone involvement known peripheral count anc patients Cluster 19: informed federal nature accordance guidelines sign written consent investigational institutional Cluster 20: hcv hepatitis hbv virus infection cleared known chronic patients eligible Cluster 21: requiring hypothyroidism autoimmune mellitus recur trigger psoriasis diabetes expected vitiligo Cluster 22: state curative survival quality therapy prolong current proven life acceptable Cluster 23: hemoglobin dl transfused level weeks unsupported hg mg randomization criterion Cluster 24: cancer adequately treated surveillance cell program patient localized followed cervical Cluster 25: aminotransferase alt ast alanine aspartate uln iuln institutional days registration Cluster 26: corticosteroids steroids systemic prednisone mg inhaled immunosuppressive topical daily doses Cluster 27: transaminase aminotransferase serum sgpt glutamic sgot glutamate pyruvate oxaloacetic alt Cluster 28: complications resolved related infectious medical significant induction consolidation therapy cycle Cluster 29: brain metastases treated patients stable prior treatment mri imaging untreated Cluster 30: investigational receiving agents patients ineligible participants study treatment trials cancer Cluster 31: score lansky years karnofsky performance age patients status paralysis ambulatory Cluster 32: contraceptive measures reproductive pregnancy effective bilateral potential use time celibacy Cluster 33: creatinine clearance gault min formula cockcroft ml calculated hour serum Cluster 34: acquisition muga ejection fraction echocardiogram left gated ventricular multi scan Cluster 35: sequencing antiretroviral combination immunodeficiency ineligible hiv biopsy virus human positive Cluster 36: understand document willingness ability written sign informed consent able guardian Cluster 37: zubrod performance status patients registration days prior criteria step study Cluster 38: creatinine clearance min ml calculated serum measured uln crcl obtained Cluster 39: leukocytes mcl mm ul lower registration equal days initiation obtained Cluster 40: bilirubin upper normal limit total uln institutional times days prior Cluster 41: swallow able pills absorb medication patients inability drug explained experiencing Cluster 42: karnofsky performance status days step registration prior score sequencing ecog Cluster 43: guardians legal parents sign written informed consent patients assent according Cluster 44: mg years age dl males creatinine females serum maximum min Cluster 45: higher neuropathy grade peripheral terminology common ctcae events adverse step Cluster 46: capsules swallow able patients tube nasogastric broken crushed inability tablets Cluster 47: major procedure surgical anticipation traumatic injury course days biopsy need Cluster 48: vessels invading encasing major blood tumor subject contact indicate participant Cluster 49: fda food nci institute met national studies requirements human administration Cluster 50: immunodeficiency hiv virus human known positive infection patients excluded individuals Cluster 51: childbearing pregnancy test potential negative women serum registration days prior Cluster 52: creatinine institutional normal levels clearance min ml upper limit patients Cluster 53: bp mmhg pressure blood antihypertensive diastolic systolic hypertension medications controlled Cluster 54: platelets mm prior weeks days equivalent cell randomization ctcae enrollment Cluster 55: representatives assent parents legally authorized according appropriate guidelines sign written Cluster 56: platelets mcl platelet transfusion transfusions requiring plt weeks equal cells Cluster 57: institutions identity process ensure board approval order open date entered Cluster 58: weeks entering recovered adverse events earlier administered nitrosoureas mitomycin agents Cluster 59: interstitial lung pneumonitis disease history pulmonary patients detection known symptomatic Cluster 60: aminotransferase aspartate ast alanine upper alt normal limit uln institutional Cluster 61: consecutive female childbearing months mature naturally potential postmenopausal menses bilateral Cluster 62: conjugated sum unconjugated age bilirubin uln upper limit normal subprotocols Cluster 63: monitoring comply safety opinion investigator able requirements eligible study patients Cluster 64: corticosteroids decreasing stable corticosteroid dose receiving days prior mri patients Cluster 65: platelet independent transfusion transfusions mm count enrollment defined receiving involvement Cluster 66: oximetry pulse dyspnea rest air room exercise evidence intolerance breathing Cluster 67: limits bilirubin normal total institutional uln upper gilberts direct registration Cluster 68: transplantation organ solid received allogeneic prior eligible patients marrow bone Cluster 69: nodal lesions mm measured measurable axis short longest recorded accurately Cluster 70: sgpt alt uln purpose alanine transaminase glutamate pyruvate aminotransferase serum Cluster 71: step registration prior weeks mcl induction screening treatment optional pre Cluster 72: gog performance gynecologic status group oncology patients grade patient protocol Cluster 73: bearing pregnancy test child negative females potential urine serum prior Cluster 74: female pregnancy childbearing potential pregnant test negative patients result urine Cluster 75: study agree contraception use male pregnant potential dose effective method Cluster 76: phase study weeks administered levels referred eligibility early recovered prior Cluster 77: fraction echocardiogram shortening ejection radionuclide angiogram gated cardiac echo study Cluster 78: hepatitis antibody positive antigen hcv surface virus negative hbsag core Cluster 79: time measurements obtain prothrombin ptt thromboplastin pt normalized inr neurologic Cluster 80: chemotherapy randomization surgery adjuvant administered days breast neoadjuvant cancer interval Cluster 81: marrow bone peripheral blood blasts biopsy aspirate patients performed involvement Cluster 82: metastatic disease locally advanced patients evidence unresectable prior cancer definitive Cluster 83: uncontrolled infection eligible patients active patient step subprotocols excluded general Cluster 84: nursing childbearing pregnancy test pregnant negative women potential required registration Cluster 85: granulocytes ul anc cells mcl absolute extending explained experiencing experimental Cluster 86: eiaed epileptic drugs inducing anti enzyme taking patients previously enrolled Cluster 87: forms medically willing sexually acceptable able contraception childbearing women men Cluster 88: investigational currently drug receiving eligible patients anticancer therapy ineligible anti Cluster 89: medications systemic adrenocortical anti tnf mineralocorticoids azathioprine orthostatic fludrocortisone dose Cluster 90: months teaspoon dose hemoptysis red treatment study indicative bleeding hemorrhage Cluster 91: ul platelet count transfusion cells independent cd unsupported platelets days Cluster 92: ischemic revascularization artery event procedures including fibrillation ventricular cerebrovascular attack Cluster 93: thromboplastin partial time aptt ptt activated uln normal upper limit Cluster 94: hodgkin expansion lymphoma cohort participants enrollment weeks prior dl serum Cluster 95: pd anti prior therapy treatment agents patients ctla antibody progression Cluster 96: consent mandatory provide specific study entry informed tissue submission including Cluster 97: monoclonal hypersensitivity antibody reaction severe history ineligible grade exclusion stratum Cluster 98: physical examination history registration days complete prior prestudy obtained patients Cluster 99: myelodysplastic mds aml leukemia myeloid syndrome acute suggestive features smear Cluster 100: albumin dl serum days registration patients prior hypersensitivity mg inclusion Cluster 101: syndrome fanconi anemia bloom telangiectasia shwachman kostmann ataxia known genetic Cluster 102: protein urine urinalysis hour mg dipstick proteinuria screened obtained electrophoresis Cluster 103: qtc prolong drugs alternatives interval receiving pointes torsades cause alternative Cluster 104: bisphosphonate hypercalcemia osteoporosis reasons taking therapy use metastasis symptomatic allowed Cluster 105: triglyceride mg dl level fasting serum applicable mmol gsk nf Cluster 106: peripheral anc neutrophil absolute mm count zubrod exposed experimental expert Cluster 107: dmso immediate chemically dimethyl sulfoxide excipients idiosyncrasy delayed trametinib hypersensitivity Cluster 108: left fraction ejection ventricular lvef normal institutional function indicated heart Cluster 109: aallb aall apecb open enrolled enrollment patients classification project sample Cluster 110: expectancy life weeks patients estimated participants physician years procurement year Cluster 111: creatinine uln serum institutional times obtained grade prior days randomization Cluster 112: performance ecog status ps patients step registration score criteria greater Cluster 113: accepted males abstain sexually intercourse effective advised sexual contraception strongly Cluster 114: phosphatase alkaline uln involvement iuln days liver prior registration bone Cluster 115: cancer breast invasive situ skin years malignancy carcinoma non melanoma Cluster 116: inhibitor parp mek prior treatment kinase braf patients received therapy Cluster 117: help occasional care karnofsky able performance status patient patients kps Cluster 118: abdominal abscess intra perforation gastrointestinal fistula months obstruction history diverticulitis Cluster 119: permitting authorization release personal information health signed approved informed consent Cluster 120: qt qtc interval milliseconds corrected torsades pointes prolongation long congenital Cluster 121: pre criteria registration eligibility inclusion step experiences experiencing experimental expert Cluster 122: humanized anaphylactic proteins chimeric antibodies fusion allergic reactions severe hypersensitivity Cluster 123: cardiac heart york association iii resulting activity iv new physical Cluster 124: corticosteroids brain anticonvulsants inducing enzyme subjects weeks stable metastases month Cluster 125: inr normalized international ratio time thromboplastin prothrombin ptt partial uln Cluster 126: transfusions hematologic evaluable toxicity provided red known platelet meet refractory Cluster 127: half lives whichever dose shorter days investigational minimum preceding study Cluster 128: major surgery days registration prior delayed immunotherapy toxicity treatment extensive Cluster 129: heart myocardial infarction failure months congestive angina history york association Cluster 130: creatinine mg dl serum registration iuln days prior umol level Cluster 131: glucose fasting mg dl blood diabetes serum mellitus age random Cluster 132: chinese hamster ovary recombinant products hypersensitivity antibodies cell human known Cluster 133: transplant stem cell allogeneic autologous prior graft host patients transplantation Cluster 134: compounds composition chemical similar attributed allergic reactions biologic history mln Cluster 135: fistula gastrointestinal perforation history abdominal months repaired postoperative starting surgically Cluster 136: tacrolimus cyclosporine transplant prevent host post versus graft marrow trial Cluster 137: anthracycline intravesical therapy prior excluded systemic patients muscle previous urothelial Cluster 138: pregnant breastfeeding women excluded study discontinued treatment drug dose refrain Cluster 139: provide informed consent written able willing ability inability patients unable Cluster 140: calc creatinine calculated min clearance ml uln upper mg normal Cluster 141: chemotherapy cancer different allowable prior systemic note study egf current Cluster 142: weeks prior therapy study completed radiation shorter recovered half toxicity Cluster 143: platelets mcl registration days prior obtained equal administration start step Cluster 144: gp inhibitors glycoprotein inducers bcrp strong binding member cypa adenosine Cluster 145: females method agreed males contraceptive reproductive effective participate unless menarchal Cluster 146: absolute neutrophil count ul anc peripheral unsupported cells lymphocyte weeks Cluster 147: oral swallow medications ability medication retain able absorption gastrointestinal unable Cluster 148: rvo retinal occlusion vein history evidence current risk csr intraocular Cluster 149: dependency tpn hydration nutrition parenteral iv total intravenous current participants Cluster 150: anc neutrophil absolute count mcl registration days prior obtained equal Cluster 151: hemoglobin dl hgb achieve intervention transfusion acceptable note use days Cluster 152: overlap fields radiation result pelvis therapy neck head irradiation previous Cluster 153: investigational agent receiving received treatment days neoplasm type patients dose Cluster 154: nursing pregnant women mothers patients excluded unwilling pregnancy step birth Cluster 155: anticonvulsants seizure inducing enzyme disorder controlled enrolled seizures patients non Cluster 156: area surface body bsa enrollment patients time study mg level Cluster 157: adverse events common terminology ctcae grade criteria version alopecia prior Cluster 158: antiretroviral combination hiv ineligible immunodeficiency positive human virus therapy patients Cluster 159: recist measurable response criteria solid evaluation disease tumors evaluable defined Cluster 160: alchemist screen alliance registered trial randomization prior patients express expressing Cluster 161: histologically confirmed cytologically cancer diagnosis metastatic patients proven unresectable cell Cluster 162: age years score walk wheelchair ambulatory assessing performance lansky patients Cluster 163: carcinoma cell squamous skin basal situ malignancies treated malignancy years Cluster 164: specific informed consent provide study registration signed representative prior legally Cluster 165: protein urine ratio upc creatinine upcr proteinuria hour dipstick collection Cluster 166: mg dl years male female age creatinine gender radioisotope gfr Cluster 167: stage iv iii disease patients cancer ii carcinoma ovarian diagnosis Cluster 168: transfusions hemoglobin rbc dl red receive blood cell requiring involvement Cluster 169: history coronary heart evidence cardiac controlled mmhg current defined subjects Cluster 170: sensory motor neuropathy grade ctcae peripheral terminology common equal events Cluster 171: blocks slides tissue notified unavailable sent chair enrollment available study Cluster 172: myelosuppressive days dose enrollment prior chemotherapy agent immunomodulatory elapsed nitrosourea Cluster 173: step randomization ii prior days dl bilirubin mg cells mm Cluster 174: hiv licensed assay record approved documentation test rapid western blot Cluster 175: return enrolling institution follow willing alliance willingness monitoring active phase Cluster 176: radiation therapy prior chemotherapy received weeks patients pelvic elapsed treatment Cluster 177: eligibility criteria step randomization registration induction meet preregistration screening operative Cluster 178: radiotherapy weeks prior chemotherapy patients therapy entering study mitomycin nitrosoureas Cluster 179: edition ajcc committee joint th american cancer stage staging nsclc Cluster 180: white wbc blood ul count cell cells randomization prior obtained Cluster 181: days events adverse infusion growth known agent elapsed occurring extended Cluster 182: rankl denosumab atezolizumab discontinue treatment inhibitor requiring patients kappa require Cluster 183: hsp inhibitor prior therapy received treatment patients zubrod expiratory experiences Cluster 184: immunocompromised hiv positive immunodeficiency virus human known corticosteroids related patients Cluster 185: laboratory clia certified mutation braf improvement clinical amendments approved mutations Cluster 186: years age lansky performance ecog karnofsky scores cooperative eastern corresponding Cluster 187: qt syndrome long congenital qtc family history ecg corrected msec Cluster 188: standard survival prolong therapy progressed histologically tumors solid shown exist Cluster 189: anc neutrophil absolute mm count cells days registration prior obtained Cluster 190: pregnant partner participating inform suspect immediately woman physician treating study Cluster 191: cns nervous central metastases involvement patients disease brain lumbar puncture Cluster 192: cytochrome subfamily cypa family polypeptide strong inhibitors inducers cypc medications Cluster 193: brain metastases carcinomatous meningitis remained stable trial patients clinical metastatic Cluster 194: reproductive contraceptive sexually effective method agreed duration potential use participation Cluster 195: infection exhibiting bacterial fungal signs despite improvement antibiotics symptoms appropriate Cluster 196: cancer adequately treated cell basal patient squamous free situ skin Cluster 197: corticosteroid dose modify corticosteroids days elapsed immune decreasing stable related Cluster 198: signs symptoms cycle infection day weeks prior tuberculosis clinical active Cluster 199: choice apecsc actionable match assignment given molecular analysis mutation presence Cluster 200: lln calcium serum magnesium potassium lower phosphorus limit normal delaying Cluster 201: feeding breast women pregnant females eligible lactating study girls menarchal Cluster 202: permit circumstances follow completion required study travel issue instance patients Cluster 203: fathering willing childbearing birth control child potential medically form treated Cluster 204: hiv retroviral positive opportunistic virus haart immunodeficiency human cd regimen Cluster 205: therapy prior chemotherapy cancer systemic patients hormonal treatment anti radiation Cluster 206: retain stomach malabsorption bowels alter medication abnormalities swallow absorption major Cluster 207: pressure blood mmhg hypertension systolic diastolic hypertensive uncontrolled controlled hg Cluster 208: egfr exon tki tm mutation generation erlotinib deletion treatment testing Cluster 209: lln echo lower left echocardiogram ejection ventricular fraction institutional limit Cluster 210: male female years creatinine age gender follows serum based radioisotope Cluster 211: pt anticoagulant ptt time thromboplastin anticoagulants intended therapeutic range partial Cluster 212: ast uln alt performed aminotransferase instead registration value lab practice Cluster 213: endotracheal endobronchial tumor evidence invading tract gi esophagus anus rectum Cluster 214: syndrome patients gilberts known excluded trisomy necrolysis stevens history epidermal Cluster 215: cholesterol mg dl level serum fasting mmol total draw gsk Cluster 216: investigational agents weeks receive past received planning patients receiving anticancer Cluster 217: wound healing fracture ulcer non bone cabozantinib dose surgeries history Cluster 218: transaminase serum aminotransferase sgot glutamic oxaloacetic ast uln aspartate sgpt Cluster 219: maximum creatinine mg dl male age serum female years gender Cluster 220: hemoglobin dl days registration prior randomization obtained step transfusions weeks Cluster 221: strong cypc miscellaneous inducers cypa inhibitors wort st antibiotics agents Cluster 222: age bilirubin total upper uln limit normal direct times institution Cluster 223: bilirubin uln total gilbert serum known level upper normal enrolled Cluster 224: significant unrelated organ dysfunction infections hepatic results interfere systemic procedures Cluster 225: phase ii arms randomized portion patients criteria registration weeks prior Cluster 226: brain metastases trial excluded clinical known patients participants described trials Cluster 227: hepatitis known infection active virus chronic hiv viral patients immunodeficiency Cluster 228: gfr glomerular filtration rate min ml creatinine radioisotope clearance estimated Cluster 229: measurable disease ct recist patients imaging tomography mri assessed resonance Cluster 230: tumors verification patients original elevations relapse fetoprotein beta hcg intrinsic Cluster 231: bilirubin gilberts uln total normal upper syndrome limit institutional unless Cluster 232: ul platelets mcl untransfused unsupported cells sequencing biopsy treatment tumor Cluster 233: cypa inducers strong inhibitors medications drugs use substances concomitant moderate Cluster 234: ctcae grade alopecia nci version institute terminology national unresolved common Cluster 235: fasting triglycerides mg dl equal cholesterol mmol lowering lipid values Cluster 236: years age enrollment patients time performance scale months lansky study Cluster 237: anti pd antibody ctla programmed death cell targeting lymphocyte cytotoxic Cluster 238: hbac glycosylated hemoglobin ac hb measurement equal registration days prior Cluster 239: seizure disorder uncontrolled history patients seizures active generalized months medication Cluster 240: specific study provide informed consent entry patient prior representative legally Cluster 241: grade alopecia toxicities recovered prior related adverse toxicity therapy patients Cluster 242: myelosuppressive weeks nitrosourea anticancer received chemotherapy study prior dose known Cluster 243: cells platelets mm days prior registration obtained entry study experiencing Cluster 244: qt interval qtc corrected msec qtcf fridericia formula electrocardiogram ms Cluster 245: mmol dl normalize mg despite intervention levels calcium hemoglobin adjusted Cluster 246: overlap fields region result radiotherapy radiation cancer therapy prior study Cluster 247: ain anal stain intraepithelial neoplasia hsil proven biopsy cyclin junction Cluster 248: bowel gastrointestinal vomiting absorption nausea resection disease significantly inflammatory diseases Cluster 249: prohibited use bisphosphonates herbal concurrent dhea ephedra ginseng dehydroepiandrosterone yohimbe Cluster 250: olaparib chemical composition compounds attributed reactions similar allergic biologic cediranib Cluster 251: hgb hemoglobin dl obtained transfusions registration days prior allowed procurement Cluster 252: live vaccine attenuated influenza vaccines vaccination flu seasonal dose study Cluster 253: consecutive undergone childbearing potential months orientation naturally meets sexual ligation Cluster 254: upper limit normal creatinine uln institutional ast serum prothrombin alt Cluster 255: registration therapy days prior radiation treatment investigational immunotherapy chemotherapy mitomycin Cluster 256: hiv cd immunodeficiency cluster differentiation positive virus human antiretroviral count Cluster 257: fast mln maintain oral hour hours medication administration required bowel Cluster 258: neuropathy grade peripheral greater patients severity exceeds registration sensory permitted Cluster 259: intact capsules swallow able patients subprotocol subprotocols assigned general tablets Cluster 260: cooperative eastern ecog group oncology performance status ps patients score Cluster 261: fcbp pregnancy lenalidomide agree effective method childbearing consecutive days commit Cluster 262: allografts organ patients zubrod experimental expert expiratory explained exploratory exposed Cluster 263: chemotherapy prior neoadjuvant patients received therapy treatment surgery radiation adjuvant Cluster 264: lar representative legally authorized understand document willingness ability sign written Cluster 265: sun exposure sunscreen protection excessive anticipated avoid willingness adequate use Cluster 266: evaluable measurable disease patients parts radiologically recist ca participants clinically Cluster 267: olaparib mother breastfeeding discontinued cediranib treated pregnant excluded women study Cluster 268: ppi pump proton inhibitor receiving dose study concomitant stop using Cluster 269: gilbert bilirubin total uln syndrome upper limit normal exception institutional Cluster 270: lactating breastfeed females plan infants eligible excluded exposure expert expiratory Cluster 271: wocbp women contraception nivolumab potential men postmenopausal childbearing use instructed Cluster 272: bilirubin total upper institutional normal limit direct range sequencing allowed Cluster 273: surgery major weeks recovered prior effects patients placement surgical study Cluster 274: women childbearing potential contraception adequate employ unwilling practice male men Cluster 275: cancers skin patient thyroid advanced known active basal screening squamous Cluster 276: breastfeed lactating agreed infants unless females eligible female pregnancy potential Cluster 277: cbc differential obtained blood count registration days complete step prior Cluster 278: currently agents anti receiving cancer eligible patients anticancer platelet study Cluster 279: receiving agents eligible corticosteroid currently anti corticosteroids investigational cypa drugs Cluster 280: permits psychological general follow health ability completion requirements required study Cluster 281: bilirubin mg dl total direct serum gilbert patient syndrome registration Cluster 282: cypc strong inducers inhibitors cyp cytochrome week preceding cypa alternative Cluster 283: malignancy melanotic cancer specific cervix situ skin carcinoma exceptions prior Cluster 284: cavitating radiographic pulmonary lesion evidence subject participant extended extensive extent Cluster 285: approaching biospecimens department regarding check release investigators submission pathology site Cluster 286: identity process ensure board approval order open entered date institution Cluster 287: bun urea nitrogen blood mg dl chloride bicarbonate glucose phosphatase Cluster 288: measurable neuroblastoma lesions disease detected fluid mibg bone collections gallium Cluster 289: tablets swallow able unable intact patients subject ability eligible chewed Cluster 290: tissue tumor biopsy available archival submission slides paraffin patients block Cluster 291: immunotherapies activating conjugates brentuximab prior vedotin restrictions checkpoint purposes monoclonal Cluster 292: creatinine gault cockcroft clearance min ml equation using calculated formula Cluster 293: cycle day herbal therapy week weeks prior contraceptives anticancer radiotherapy Cluster 294: inhibitors azacitidine decitabine deacetylase histone hydroxyurea interferon tyrosine hematopoietic thalidomide Cluster 295: autoimmune disease systemic syndrome replacement history patients sclerosis treatment arthritis Cluster 296: cycle day investigational agent weeks treatment prior past agents received Cluster 297: dipg stratum progressed progressive recurrent non patients irradiation refractory enrollment Cluster 298: dimension mm ct diameter lesion spiral longest recorded measurable accurately Cluster 299: infection active requiring systemic antibiotics severe patients therapy fungal septicemia