Major surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXUndergo major surgical procedure within 28 days prior to first bevacizumab dose, or anticipation of the need for a major surgical procedure during the course of the study except participants who receive NACT and will need interval surgery. This may include but is not limited to laparotomy.Xx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to randomization or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to randomization or anticipation of need for a major surgical procedure during the course of the study other than for diagnosisXx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 and patients must have recovered from any effects of any major surgery; anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to planned initiation of study therapyXx_NEWLINE_xXMajor surgery =<4 weeks before first dose of study drug or incomplete recovery from a prior major surgical procedureXx_NEWLINE_xXMajor surgical procedure within 28 days prior to the study.Xx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to Day 1Xx_NEWLINE_xXMajor surgical procedure, other than for diagnosis, within 4 weeks prior to initiation of study treatment, or anticipation of need for a major surgical procedure during the study;Xx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 4 weeks before initiation of study treatment, or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXPrior major surgical procedure or radiation therapy within 4 weeks of the randomizationXx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 28 days prior to Day 1 of Cycle 1, or anticipation of a major surgical procedure during the studyXx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to randomization or anticipation of the need for a major surgical procedure during the study other than for diagnosisXx_NEWLINE_xXSubject who has undergone a major surgical procedure (as defined by the Investigator) within 28 days prior to the first dose of KHK2455 or is still recovering from prior surgery;Xx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXPrior radiation therapy or chemotherapy within 2 weeks or major surgical procedure within 4 weeks of the first dose of study treatmentXx_NEWLINE_xXPatients who have had radiotherapy or minor surgical procedure within 14 days, or major surgical procedure within 28 days prior to administration of first dose of study drug are not eligible; patients with inadequate recovery from prior surgical procedure are also not eligibleXx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 4 weeks prior to initiation of study treatment, or anticipation of need for a major surgical procedure during the studyXx_NEWLINE_xXMajor surgical procedure within 28 days prior to Day 1 of Cycle 1.Xx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to initiation of study treatment or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 28 days prior to initiation of study treatment or anticipation of need for a major surgical procedure during the course of the study.Xx_NEWLINE_xXMust not have undergone a major surgical procedure < 4 weeks prior to registrationXx_NEWLINE_xXMajor surgical procedures < 28 days from beginning study treatmentXx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 28 days prior to Cycle 1, Day 1Xx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 4 weeks prior to initiation of study treatment, or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXPlanned surgical procedure within the next 90 daysXx_NEWLINE_xXMajor surgical procedure within 4 weeks prior study treatment initiationXx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure other than cystectomy during the course of the studyXx_NEWLINE_xXInadequate recovery from any prior surgical procedure, or having undergone any major surgical procedure within 4 weeks prior to C1/D1.Xx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the study with the exception of the planned breast cancer surgery that is part of the trial designXx_NEWLINE_xXHistory of a major surgical procedure or a significant traumatic injury within 14 days prior to commencing treatment, or the anticipation of the need for a major surgical procedure during the course of the study.Xx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to randomisation or anticipation of the need for a major surgical procedure during the course of the study other than for diagnosisXx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 4 weeks prior to initiation of study treatment\r\n* Placement of a stent or central venous access catheter (e.g., port or similar) is not considered a major surgical procedure and is therefore permittedXx_NEWLINE_xXMajor surgical procedure within 28 days prior to start of study treatment or anticipation of need for a major surgical procedure during the course of the study. This does not refer to the planned liver metastasectomy that is part of the study.Xx_NEWLINE_xXInadequate recovery from any prior surgical procedure, or having undergone any major surgical procedure within 4 weeks prior to C1/D1.Xx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure (as defined by the Investigator) within 14 days prior to the start of study treatmentXx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to initiation of study treatment of anticipation of need for a major surgical procedure during the course of the study other than for diagnosisXx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 28 days prior to study treatment or anticipation of need for a major\r\nsurgical procedure during the course of the studyXx_NEWLINE_xXAny major surgical procedure within 4 weeks of first study treatmentXx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 28 days prior to cycle 1 day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXConcomitant medical problems that would place the patient at unacceptable risk for a major surgical procedureXx_NEWLINE_xXMajor surgical procedure ? 2 weeks prior to enrolment or anticipation of need for a major surgical procedure during the course of the study other than for diagnosis.Xx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure =< 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXInvasive surgical procedure within 28 days prior to study pre-registrationXx_NEWLINE_xXMajor surgical procedure within 4 weeks of first study treatmentXx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure (e.g. laparotomy, bowel resection) 4 weeks prior to start of the study drugXx_NEWLINE_xXMust have fully healed from any surgical procedure to be safe for lumbar puncture according to treating neurosurgeon and at least 14 days should have elapsed since the surgical procedureXx_NEWLINE_xXMajor surgical procedure within four weeks prior to administration of the first dose of ARQ 751 a. To be eligible for the study treatment, all surgical wounds must be fully healed and any surgery-related adverse events must recover to Grade ? 1.Xx_NEWLINE_xXMajor surgical procedure (as defined by the investigator) within 28 days prior to the first dose of MEDI4736 and tremelimumab or still recovering from prior surgeryXx_NEWLINE_xXPatients who have had any major surgical procedure within 14 days of day 1Xx_NEWLINE_xXMajor surgical procedure within 21 days prior to enrollmentXx_NEWLINE_xXMajor surgical procedure within 28 days of study enrollment, or anticipated while on studyXx_NEWLINE_xXMajor surgical procedure within four weeks prior to administration of the first dose of study drug • To be eligible for study treatment, all surgical wounds must be fully healed and any surgery-related adverse events (AE) must recover to Grade ? 1Xx_NEWLINE_xXPatients who have had any major surgical procedure within 14 days of Day 1. BM biopsy is not considered a major surgical procedure.Xx_NEWLINE_xXPatients with a major surgical procedure or other investigational agents within 30 days before study enrollmentXx_NEWLINE_xXPatients will be ineligible if they have any concomitant cardiopulmonary disease which would place them at unacceptable risk for a major surgical procedureXx_NEWLINE_xXAnticipation of need for major surgical procedure during the course of the studyXx_NEWLINE_xXPatients who have had any major surgical procedure within 14 days of Day 1.Xx_NEWLINE_xXPatients less than 2 weeks post major surgical procedure (all surgical wounds must be fully healed). For the purpose of this criterion, a major surgical procedure is defined as one requiring the administration of general anesthesiaXx_NEWLINE_xXPatients with non-healing surgical wounds; patients must be at least two weeks from a major surgical procedure, and surgical wounds must be completely healedXx_NEWLINE_xXPatients must have recovered from any surgical procedure before enrolling on this studyXx_NEWLINE_xXAnticipation of need for major surgical procedure during the course of the study other than as outlined by the protocolXx_NEWLINE_xXSubject has had a major surgical procedure and has not completely recovered within 28 days prior to the start of study treatment.Xx_NEWLINE_xXInadequate recovery from any prior surgical procedure, or having undergone any major surgical procedure within 4 weeks prior to C1/D1.Xx_NEWLINE_xXHistory of a major surgical procedure or a significant traumatic injury within 14 days prior to commencing treatment, or the anticipation of the need for a major surgical procedure during the course of the study.Xx_NEWLINE_xXPatients who have had a surgical procedure unrelated to the study within 14 days or major surgery within 1 month prior to the administration of the study drugXx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to randomization. Patient must have recovered from all surgery-related complications.Xx_NEWLINE_xXPatients who have major surgical procedure, other than for diagnosis, within 28 days before initiation of study treatment or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the study.Xx_NEWLINE_xXMajor surgical procedure (including open biopsy, excluding central line intravenous (IV) and port-a-cath placement) within ? 14 days prior to initiating study treatment, or anticipation of the need for major surgery during the course of the study treatmentXx_NEWLINE_xXMajor surgical procedure =< 28 days prior to registration or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure (as defined by the treating physician) within 28 days prior to the first dose of durvalumab and tremelimumab or still recovering from prior surgeryXx_NEWLINE_xXNon-study related minor surgical procedure =< 5 days, or major surgical procedure =< 21 days, prior to the first dose of rucaparib; in all cases, patients must be sufficiently recovered and stable before treatment administrationXx_NEWLINE_xXPatients will be ineligible if they have any concomitant cardiopulmonary disease which would place them at unacceptable risk for a major surgical procedureXx_NEWLINE_xXPatients who have had any major surgical procedure within 14 days of day 1Xx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 4 weeks prior to initiation of study treatment or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXConcomitant medical problems that would place the patient at unacceptable risk for a major surgical procedureXx_NEWLINE_xXMajor surgical procedure less than 4 weeks from start of protocol treatmentXx_NEWLINE_xXMajor surgical procedure within 4 weeks of treatmentXx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to enrolment.Xx_NEWLINE_xXAnticipation of need for major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedures are not allowed ?28 days prior to FPA144 administrationXx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 28 days prior to first dosing or during the course of the study.Xx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to Study Day 1Xx_NEWLINE_xXMajor surgical procedure within 28 days prior to Day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXAnticipation of need for major surgical procedures during the course of study.Xx_NEWLINE_xXInadequate recovery from any prior surgical procedure or major surgical procedure within 4 weeks prior to administration of first dose of study drug.Xx_NEWLINE_xXThe subject had a major surgical procedure, substantial open biopsy, or significant traumatic experience within 28 days before the Day 1 visit, or anticipation of need for major surgical procedure during the course of the study.Xx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 4 weeks prior to initiation of study treatment, or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 30 days prior to Day -31 or still recovering from prior surgeryXx_NEWLINE_xXAnticipate having a major surgical procedure during the course of the study.Xx_NEWLINE_xXMajor surgical procedure (as defined by the investigator) within 30 days prior to Study Day 1 or incomplete recovery from any prior surgery.Xx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 28 days prior to Day 1 of Cycle 1, or anticipation of a major surgical procedure during the course of the studyXx_NEWLINE_xXPatients who have had any major surgical procedure within 28 days prior to day 1Xx_NEWLINE_xXMajor surgical procedure within 28 days prior to Cycle 1, Day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the study; transurethral resection or other urinary tract diagnostic procedures, excisional biopsy, or MediPort placement, are NOT defined as major surgical proceduresXx_NEWLINE_xXMajor surgical procedure within 2 weeks prior to starting treatment; patients must have recovered from any effects of any major surgery and surgical wound should have healed prior to starting treatmentXx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXAnticipation of need for major surgical procedure =< 6 months after randomizationXx_NEWLINE_xXSubject is undergoing a neurologic surgical procedure;Xx_NEWLINE_xXSubject is undergoing a spinal surgical procedure;Xx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 28 days prior to D1C1Xx_NEWLINE_xXMajor surgical procedure within 21 days prior to the first dose of IP.Xx_NEWLINE_xXMajor surgical procedure within 28 days prior to treatment start or anticipation of need for a major surgical procedure during the course of the study (endobronchial ultrasound [EBUS] and mediastinoscopy and video-assisted thoracoscopic surgery [VATS] are not considered major surgical procedures)Xx_NEWLINE_xXMajor surgical procedure within 28 days prior to the first dose of Investigational Product;Xx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 4 weeks prior to randomizationXx_NEWLINE_xXSurgical axillary staging procedure prior to study procedure (with exception of FNA or core biopsy).Xx_NEWLINE_xXMajor surgical procedure within 28 days prior to the first dose of Investigational ProductXx_NEWLINE_xXPlanned/or anticipated major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 28 days prior to Cycle 1, Day 1Xx_NEWLINE_xXPatients will be ineligible if they have any concomitant cardiopulmonary disease which would place them at unacceptable risk for a major surgical procedureXx_NEWLINE_xXMajor surgical procedure within 28 days, or anticipation of the need for major surgical procedure during the course of the study as well as minor surgical procedure within 7 days prior to study enrollmentXx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 28 days prior to Cycle 1 Day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure (as defined by the investigator) within 30 days prior to Day 1 or still recovering from prior surgery.Xx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXRadiotherapy or minor surgical procedure within 2 weeks, or major surgical procedure within 4 weeks prior to administration of first dose of study drug; inadequate recovery from prior surgical procedureXx_NEWLINE_xXMajor surgical procedure within 4 weeksXx_NEWLINE_xXMajor surgical procedure within 4 weeks (28 days) prior to enrollment (port placement is not considered a major surgical procedure)Xx_NEWLINE_xXAnticipation of immediate need for a major surgical procedure (e.g., impending bowel obstruction, gastrointestinal perforation) or radiation therapy during the trialXx_NEWLINE_xXMajor surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to day -3 or anticipation of need for major surgical procedure during the course of the study; (a major surgical procedure constitutes an invasive procedure which requires general anesthetic support, hospitalization, and supportive care such as laparotomy, laminectomy, etc.)Xx_NEWLINE_xXAny major surgical procedure or radiation within 4 weeks of first study treatmentXx_NEWLINE_xXPatients less than 4 weeks post major surgical procedure (all surgical wounds must be fully healed); for the purpose of this criterion, a major surgical procedure is defined as one requiring the administration of general anesthesiaXx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 28 days of day 1 of therapyXx_NEWLINE_xXAnticipation of need for major surgical procedures during the course of the studyXx_NEWLINE_xXMajor surgical procedure (including periodontal) within 4 weeksXx_NEWLINE_xXSubject has had a major surgical procedure (other than a biopsy) within 14 days prior to the first dose of study drug, or one is planned during the course of the study.Xx_NEWLINE_xXMajor surgical procedure, open biopsy, or significant traumatic injury within 4 weeks before enrollment or anticipation of need for major surgical procedure during the course of the study; subjects with limited metastatic disease that has been surgically resected may enter and begin study therapy 3 weeks after surgery and the bevacizumab containing portion of the regimen may begin no sooner than 4 weeks after surgery\r\n* If, during the course of the study, a subject progresses on therapy to the point that surgical resection is recommended, the subject should be discontinued from the study but is eligible for re-enrollment into the study after the surgical resection provided all inclusion/exclusion criteria are metXx_NEWLINE_xXMajor surgical procedure (other than study related biopsy), or a major surgical procedure is planned to occur during the planned study durationXx_NEWLINE_xXMajor surgical procedure within 28 days prior to Cycle 1, Day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXSubject has had a major surgical procedure (other than study-related biopsy) within 14 days prior to the first dose of study drug, or a major surgical procedure is planned to occur during the study.Xx_NEWLINE_xXPatients who have had any major surgical procedure within 14 days of day 1Xx_NEWLINE_xXMajor surgical procedure within 30 days prior to the first dose of investigational product or still recovering from prior surgeryXx_NEWLINE_xXRadiation therapy or major surgical procedure within 4 weeks of the first dose.Xx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 4 weeks prior to the first dose of study treatment, or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to Day 1Xx_NEWLINE_xXA major surgical procedure within 4 weeks prior to the planned first day of study drug dosing or a surgical procedure is planned during the course of the study.Xx_NEWLINE_xXMajor surgery ?4 weeks before first dose of study drug, or incomplete recovery from a prior major surgical procedureXx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to initiation of study treatmentXx_NEWLINE_xXSurgical procedure or clinically significant trauma within 2 weeks of first dose of study treatmentXx_NEWLINE_xXMajor surgical procedure within 30 days prior to Day 1 or incomplete recovery from any prior surgeryXx_NEWLINE_xXHistory of major surgical procedure within 28 days prior to start of study treatmentXx_NEWLINE_xXPatient who has undergone recent major surgery, other than diagnostic surgical procedure within 4 weeks prior to randomizationXx_NEWLINE_xXAny major surgical procedure within 3 weeks prior to the first dose of study drug;Xx_NEWLINE_xXPrior chemotherapy or a major surgical procedure within 3 weeks, or radiotherapy within 2 weeks prior to first study treatmentXx_NEWLINE_xXCore biopsy or other minor surgical procedure within 7 days prior to study startXx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to Day 1Xx_NEWLINE_xXPatients with inadequate recovery from any prior surgical procedure, or patients having undergone any major surgical procedure within 4 weeks prior to first study drug administration.Xx_NEWLINE_xXPatients with inadequate recovery from any prior surgical procedure, or patients having undergone any major surgical procedure within 1 month prior to first study drug administration.Xx_NEWLINE_xXUndergone a therapeutic surgical procedure within 30 days from the screening visit.Xx_NEWLINE_xXPatients who have had a major surgical procedure within the past 6 weeksXx_NEWLINE_xXMajor surgical procedure within 28 days prior to Cycle 1, Day 1, or anticipation of need for a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 90 daysXx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to study treatmentXx_NEWLINE_xXMajor surgical procedure within 28 days prior to study enrollmentXx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to Day 1Xx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to Cycle 1, Day 1Xx_NEWLINE_xXPatients must be less than 4 months from the surgical procedure for this recurrenceXx_NEWLINE_xXMajor surgical procedure(s) within previous 4 weeks prior to study enrollmentXx_NEWLINE_xXMajor surgical procedure other than for diagnosis within 28 days prior to Cycle 1, Day 1 or anticipation of a major surgical procedure during the course of the studyXx_NEWLINE_xXMajor surgical procedure within 4 weeks of treatmentXx_NEWLINE_xXPatients who have had any major surgical procedure within 14 days of day 1Xx_NEWLINE_xXA major surgical procedure (other than study related biopsy), or a major surgical is planned to occur during the studyXx_NEWLINE_xXSurgical procedure where both arms are required to be tucked at the patient's sideXx_NEWLINE_xXMajor surgical procedure within 21 days of first study treatmentXx_NEWLINE_xXMajor surgical procedure or significant traumatic injury within 4 weeks prior to initiation of study drug, or anticipation of need for major surgical procedure during the course of the studyXx_NEWLINE_xXHas had a major surgical procedure, other than for HNC, or significant traumatic injury within 4 weeks prior to the initiation of RT; anticipation of need for major surgical procedure during the course of the studyXx_NEWLINE_xXPatient is within 2 months of a major surgical procedureXx_NEWLINE_xXPlanned surgical procedureXx_NEWLINE_xXDefinitive breast surgical procedure prior to enrollment.Xx_NEWLINE_xXMajor surgical procedure within 4 weeks of first study treatmentXx_NEWLINE_xXPatient must have recovered from any surgical procedure before enrolling on this studyXx_NEWLINE_xXPatient must not require a major surgical procedure =< 21 days prior to beginning therapyXx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to randomization or anticipation of the need for a major surgical procedure during the course of the study other than for diagnosis; placement of central venous access catheter(s) (e.g., port or similar) is not considered a major surgical procedure and is therefore permittedXx_NEWLINE_xXPrior major surgical procedure or radiation therapy within specified period of the first dose of study treatment (with defined exception).Xx_NEWLINE_xXPatient must be able to tolerate a major surgical procedure based on clinical evaluation, status of their cancer, and any other underlying medical problemsXx_NEWLINE_xXMajor surgical procedure within 4 weeks prior to randomization or anticipation of need for a major surgical procedure during the course of the study other than for diagnosisXx_NEWLINE_xX