Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXWithin 2 weeks prior to screening step registration and within 4 weeks prior to treatment step registration: Creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< institutional upper limit normal (ULN), CTCAE v 3.0 grade 0; NOTE: if creatinine > ULN, creatinine clearance must be > 50 mL/minXx_NEWLINE_xXCreatinine =< 1.5 times institutional upper limit of normal (ULN) OR calculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXSerum creatinine below the upper limit of the institutional normal range (ULN) or creatinine clearance ? 60 mL/min/1.73 m2 for patients with serum creatinine levels above institutional ULN.Xx_NEWLINE_xXcreatinine clearance ?60 mL/min/1.73 m2 for subjects with serum creatinine levels >1.5 × higher than ULN.Xx_NEWLINE_xXCreatinine < 1.5 x institutional upper limit of normal or creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< institutional upper limit or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXMeasured within 28 days prior to registration: serum or plasma creatinine =< 1.5 x institutional upper limit of normal (ULN) OR creatinine clearance >= 51 mL/min/1.73 m^2 for participantsXx_NEWLINE_xXCreatinine clearance >= 50 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above 1.5 x upper limit of normalXx_NEWLINE_xXRenal: serum creatinine ?1.5 × ULN or calculated creatinine clearance or glomerular filtration rate >50 mL/min/1.73 m2 for subjects with creatinine levels above institutional normal.Xx_NEWLINE_xXCreatinine =< 1.5 x IULN or >= 60 ml/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal (using Cockcroft Gault formula)Xx_NEWLINE_xXAcceptable renal function: o Serum creatinine within normal limits, OR calculated creatinine clearance 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal.Xx_NEWLINE_xXINCLUSION CRITERIA FOR SECOND-LINE THERAPY: Serum creatinine =< 1.5 X upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXINCLUSION CRITERIA FOR THIRD-LINE THERAPY: Serum creatinine =< 1.5 X upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine < 1.5 mg/dL OR creatinine clearance ? 60 mL/min/1.73 m^2 for patients with creatinine levels > institutional normal within 14 days of registrationXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x above institutional normal or >= 60 ml/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x the upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x the upper limit of normalXx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 x institutional upper limit of normal or creatinine clearance > 60 mL/min/1.73 m^2 (per 24 hour urine collection or calculated according to the Cockcroft-Gault formula) for subjects with creatinine levels above the institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 50 mL/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine at or below IULN (males 0.7-1.30 mg/dl; females 0.6-1.10 mg/dl) OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine < 2 mg/dL OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (unless elevated creatinine or creatinine clearance felt by investigator to be acute and reversible)Xx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance > 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (using Cockcroft-Gault formula)Xx_NEWLINE_xXCreatinine within institutional normal limits (WNL) OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x institutional ULN OR creatinine clearance >= 60 mL/min by Cockcroft-Gault equation for participants with creatinine levels above institutional normal.Xx_NEWLINE_xXSerum creatinine =< 1.5 x institutional ULN, OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with serum creatinine levels above 1.5 x institutional ULNXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance ? 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXObtained within 21 days prior to study registration: creatinine within normal institutional limits OR creatinine clearance ? 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 times the normal upper institutional limit OR creatinine clearance >= 60 mL/min/1.73 m^2 in participants with creatinine levels > 1.5 times the normal upper institutional limitXx_NEWLINE_xXSerum creatinine or creatinine clearance =< institutional upper limit or >= 60 mL/min creatinine clearance for patients with serum creatinine > institutional upper limitXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal or calculated creatinine clearance >= 60 mL/min using Cockcroft-Gault equation for patients with creatinine levels > 1.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXSerum creatinine =< 1.5 x institutional upper limit of normal (ULN) OR calculated creatinine clearance >= 50 mL/min for subjects with creatinine levels > 1.5 x institutional ULN within 28 days of treatment initiation and must be independent of hematopoietic growth factor supportXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine ? 1.5 x institutional ULN OR creatinine clearance ? 60 mL/min by Crockoft-Gault for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within upper normal institutional limit OR creatinine clearance >= 50 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional ULNXx_NEWLINE_xXCreatinine =< 1.5 x within normal institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional ULNXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 x institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with serum creatinine levels > 1.5 x higher than institutional normalXx_NEWLINE_xXCreatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with serum creatinine levels above institutional normal (IULN) (calculated by creatinine clearance estimate by Cockcroft-Gault equation)Xx_NEWLINE_xXCreatinine clearance >= 50 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXWithin 2 weeks prior to initiation of study treatment: Creatinine =< upper limit of institutional normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x ULN or a creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, determined within 14 days of registrationXx_NEWLINE_xXWithin 28 days of study registration: Normal serum creatinine or creatinine clearance >= 60 ml/min/1.73 m^2Xx_NEWLINE_xXCreatinine =< institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine within normal institutional limits or creatinine clearance >= 40 ml/minXx_NEWLINE_xXCOHORT I: Creatinine < 2 x upper limit of normal (ULN) or creatinine clearance >= 45 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 x institutional normalXx_NEWLINE_xXCreatinine =< upper limit of normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN) OR creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (obtained =< 14 days prior to registration)Xx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 x institutional upper limit of normal (IULN) OR creatinine clearance by Cockcroft-Gault >= 60 mL/min for patients with serum creatinine > 1.5 x IULNXx_NEWLINE_xXCreatinine < 2 x institution upper limit of normal OR creatinine clearance > 45 mL/min/1.73 m^2, for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits, OR creatinine clearance >= 60 mL/min, based either on Cockcroft-Gault estimate or based on urine collection (12 or 24 hour), for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 X institutional upper limit of normal OR measured creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normalXx_NEWLINE_xXSerum creatinine < 2 x institutional upper limit of normal OR creatinine clearance >= 50 mL/min/for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 mg/dLXx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine ? 1.5 x upper limit of normal (ULN) OR creatinine clearance ? 50 mL/min/1.73 m^2 (using Cockroft Gault Formula) for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 60 Ml/min/1.73 m^2 for patients with creatinine levels above institutional normal.Xx_NEWLINE_xXCreatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal.Xx_NEWLINE_xXCreatinine ? 1.5 x IULN OR creatinine clearance ? 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x IULN or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN) OR creatinine clearance > 50 mL/min/1.73 m2 for patients with creatinine levels =< 1.5 x upper limit above institutional normalXx_NEWLINE_xXCreatinine < institutional upper limit of normal (ULN) OR creatinine clearance >= 50 mL/min for patients with creatinine levels greater than ULNXx_NEWLINE_xXSerum creatinine =< 1.5 x institutional upper limit of normal (IULN) and creatinine clearance >= 75 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x institutional ULN, OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with serum creatinine levels > 1.5 x higher than institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance ? 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 times normal institutional limits OR creatinine clearance >= 40 ml/min for patientsXx_NEWLINE_xXCreatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< upper limit of normal (ULN) OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above normal within 14 days of treatment initiationXx_NEWLINE_xXCreatinine clearance >= 45 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal.Xx_NEWLINE_xXObtained with 21 days of registration: creatinine =< 2 x institutional upper limit of normal OR creatinine clearance > 60 mL/min for patients with creatinine levels greater than institutional upper limit of normalXx_NEWLINE_xXCreatinine =<1.5 x normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 x institutional normalXx_NEWLINE_xXCreatinine =< 1.6 mg/ml OR creatinine clearance (estimated glomerular filtration rate [eGFR]) >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal at the time DAC-THU and pembrolizumab treatment commencesXx_NEWLINE_xXCreatinine =< 1.5 mg/dl or creatinine clearance >= 60 mL/min/1.73 m^2 (calculated per Cockcroft & Gault formula) for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within institutional normal limits or, clearance > 60 mL/ minute if serum creatinine is elevated above institution upper limit (UL)Xx_NEWLINE_xXCreatinine < 1.5 X institution upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2, for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine within the institutional normal limits, OR if the creatinine is elevatedXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (by the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation)Xx_NEWLINE_xXCreatinine up to 1.5 upper institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal 14 days or fewer from registrationXx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance (estimated glomerular filtration rate [eGFR]) >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels >= 1.5 x upper limit of normal (after the HDT/ASCT)Xx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine < 1.5 X institution upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 2.0 OR creatinine clearance > 30 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 ULN OR creatinine clearance >= 60 Ml/min/1.73 m^2 for patients with creatinine levels above ULN calculated using Calvert formulaXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (creatinine clearance should be calculated per institutional standard)Xx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance > 60 mL/min/1.73 m^2 by Cockcroft-Gault formulaXx_NEWLINE_xXCreatinine levels within normal institutional limits; or, creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal; unless decreased due to renal involvement by lymphomaXx_NEWLINE_xXSerum creatinine below institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with serum creatinine levels above institutional ULNXx_NEWLINE_xXCreatinine =< 1.5 ULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXOR creatinine clearance >= 60 mL/min for patients with creatinine levels above 1.5 X institutional upper limit of normalXx_NEWLINE_xXSerum creatinine within normal institutional limits or creatinine clearance > 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, assessed within 14 days prior to registrationXx_NEWLINE_xXSerum creatinine =< 1.5 x upper normal limit of institution's normal range or creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 2 x normal institutional limits OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal as defined by the Cockcroft-Gault equationXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN), or measured creatinine clearance >= 60 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits; OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance > 60 mL/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine within normal institutional limits OR measured creatinine clearance >= 50 mL/min/for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine < 1.5 x institution upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2, for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 2.0 x ULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for participants with creatinine levels above 2.0 x ULNXx_NEWLINE_xXCreatinine < 1.5 mg/dL OR creatinine clearance >= 50 mL/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine 1.5 x the normal institutional limits OR creatinine clearance >= 40 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance > 60 mL/min/1.73 m^2 by Cockcroft-Gault formulaXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/ per Cockroft-Gault equation\r\nfor patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< institutional upper limit of normal OR creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine not greater than upper institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance >= 45 mL/min/1.73 m^2 as estimated by either Cockcroft-Gault or 24-hour urine collection for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance: > 60 ml/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limits of normal OR creatinine clearance of >= 50 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal by 24-hour urineXx_NEWLINE_xXSerum creatinine =< 1.5 x IULN OR creatinine clearance by Cockcroft-Gault >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x IULNXx_NEWLINE_xXSerum creatinine =< 1.5 x IULN OR creatinine clearance by Cockcroft-Gault >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x IULNXx_NEWLINE_xXCreatinine clearance >= 60 Ml/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal; creatinine clearance should be calculated using the actual weight from day 1 of the cycleXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance > 50 mL/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine level within normal institutional limit, or creatinine clearance > 15 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, calculated using the Cockcroft-Gault formula)Xx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance < 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x ULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (Cockcroft formula)Xx_NEWLINE_xXCreatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine below institutional ULN or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 X ULN OR calculated creatinine clearance >= 60 mL/min for patients with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXPHASE I STUDY ELIGIBILITY CRITERIA:\r\nCreatinine =< 1.5 X within normal institutional limits OR measured creatinine clearance >= 50 mL/min/1.73 m^2Xx_NEWLINE_xXCalculated creatinine clearance ? 60 mL/min /1.73 m2 for subjects with serum creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXCreatinine =< the institutional upper limit of normal (ULN) OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance >= 60 mL/minXx_NEWLINE_xXSerum creatinine ? 1.5 × ULN OR creatinine clearance ? 50mL/min/1.73 m2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine below ULN (males 0.7-1.30 mg/dl; females 0.6-1.10 mg/dl) OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, determined within 14 days of registrationXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance > 45 mL/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXMeasured OR estimated creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above normalXx_NEWLINE_xXCreatinine within normal institutional limits (< 1.5) OR creatinine clearance >= 50 mL/min/1.73m^2 (for creatinine level above normal)Xx_NEWLINE_xXCreatinine =< institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine above institutional upper limit of normal (IULN) obtained no more than 28 days prior to the start of neoadjuvant endocrine therapyXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine < 1.5 x institutional upper limit of normal (ULN), OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels greater than 1.5 x ULNXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal or creatinine clearance >= 60 ml/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limit of normal or creatinine clearance >= 50 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (within 2 weeks prior to radiotherapy)Xx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR calculated creatinine clearance >= 60 mL/min for patients with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 × upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXWithin 4 weeks of preregistration: Creatinine =< institutional upper limit of normal (ULN) OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXELIGIBILITY CRITERIA FOR REGISTRATION: creatinine =< institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (within one week of registration if patient postop, otherwise within two weeks of registration)Xx_NEWLINE_xXRenal: serum creatinine within normal limits (WNL), defined as within 10% of the institution's stated reference range, or a calculated creatinine clearance >60 mL/min/1.73 m2 for patients with abnormal, increased, creatinine levels. Patients with Multiple Myeloma (only): serum creatinine ? 2.5 the institutional upper limit of the normal range and a calculated creatinine clearance > 40 mL/min/1.73 m2.Xx_NEWLINE_xXcreatinine clearance greater than or equal to 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 mg/dLXx_NEWLINE_xXCreatinine =< 1.5 x institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 mg/dLXx_NEWLINE_xXREGISTRATION TO TREATMENT (STEP 1): Serum creatinine =< 1.5 X upper limit of normal (ULN) OR creatinine clearance (per institutional standards) >= 60 mL/min for patient with creatinine levels > 1.5 X ULN, within 14 days prior to first dose of pembrolizumabXx_NEWLINE_xXREGISTRATION TO TREATMENT (STEP 2): Serum creatinine =< 1.5 X upper limit of normal (ULN) OR creatinine clearance (per institutional standards) >= 60 mL/min for patient with creatinine levels > 1.5 X ULN, within 14 days prior to first dose of pembrolizumabXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x IULN OR creatinine clearance >= 40 mL/min by Cockcroft-Gault for patients with creatinine levels above institutional normalXx_NEWLINE_xXWithin 10 days of treatment initiation: If serum creatinine concentration >= 1.5 x upper limit of normal (ULN), then estimated creatinine clearance must be >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXCreatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 X upper normal limit of institution's normal range OR creatinine clearance >= 40 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal; creatinine clearance should be determined by the Cockcroft-Gault formula or by 24-hour urine collection for determination of creatinine clearanceXx_NEWLINE_xXCreatinine level within normal institutional limit, or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine level above institutional normalXx_NEWLINE_xXCreatinine < 1.5x institutional upper limits of normal (ULN) or creatinine clearance ? 60 mL/(min 1.73 m^2) for patients with elevated creatinine levels (? 21d of study day 1)Xx_NEWLINE_xXCreatinine clearance > 50 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal limitsXx_NEWLINE_xXEXCLUSION CRITERIA FOR TREATMENT: Creatinine clearance > 50 ml/min/1.73m^2 for patients with creatinine levels above institutional normal limitsXx_NEWLINE_xXCreatinine < 1.5 x institutional upper limit of normal (ULN) OR creatinine clearance (CrCl) >= 50 mL/min/1.73 m^2 for subjects with creatinine levels greater than 1.5 x ULNXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine levels =< upper limit of institutional normal; or creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< the institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x ULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXTUMOR BIOPSY SEQUENCING: Creatinine < 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min for patients with creatinine levels >= 1.5 x institutional upper limit of normalXx_NEWLINE_xXTREATMENT: Creatinine < 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min for patients with creatinine levels >= 1.5 x institutional upper limit of normalXx_NEWLINE_xXCreatinine within normal institutional limits OR calculated creatinine clearance >= 60 mL/min/1.73 m^2 (Cockroft-Gault formula) for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal (derived by the Cockcroft-Gault formula)Xx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine < 1.5 x ULN OR creatinine clearance measured >= 60 mL/minute for patients with creatinine levels >= 1.5 x upper limit of normalXx_NEWLINE_xXCreatinine < 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 × upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 mg/dL or creatinine clearance (Cockcroft-Gault) >= 60 mL/min for patients with creatinine levels above institutional upper limit of normal (ULN)Xx_NEWLINE_xXPHASE II: Creatinine =< 1.5 mg/dL or creatinine clearance (Cockcroft-Gault) >= 60 mL/min for patients with creatinine levels above institutional upper limit of normal (ULN)Xx_NEWLINE_xXCreatinine within normal institutional limits OR calculated creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine within normal institutional limits or creatinine clearance must be at least 60 ml/minXx_NEWLINE_xXCreatinine < 1.5 x normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine level above institutional normal based either on Cockroft-Gault estimate or based on urine collection (12 or 24 hour)Xx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 X institutional upper limit of normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 times the upper limit of normal (ULN) OR creatinine clearance >= 60 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine < 1.5 x institutional upper limit of normal OR creatinine clearance > 60 ml/min OR > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< institutional upper limit normal (ULN); note: if creatinine > ULN, creatinine clearance must be > 50 mL/minXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine within normal institutional limits or a creatinine clearance >= 60 mL/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 X ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x ULNXx_NEWLINE_xXPHASE II: Creatinine =< 1.5 X ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x ULNXx_NEWLINE_xXCreatinine =< 1.5 x IULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine within normal institutional limits or a creatinine clearance >= 60 ml/min within 2 weeks prior to registrationXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits for age OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above ULNXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 x IULN OR calculated creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 x institutional ULN OR creatinine clearance >= 45 mL/min/ 1.73 m^2 for participants with creatinine levels above institutional ULNXx_NEWLINE_xXCreatinine =< 1.5 × institutional upper limit of normal OR creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 x institutional limit of normalXx_NEWLINE_xXCreatinine =< 1.5 x ULN OR calculated or measured creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine above institutional normalXx_NEWLINE_xXCreatinine ? 1.5 × ULN or, for patients with creatinine levels above institutional upper limit of normal, creatinine clearance must be > 60 mL/min/1.73 m^2.Xx_NEWLINE_xXCreatinine clearance >60 mL/min/1.73 m2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 60 Ml/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional limitsXx_NEWLINE_xXCreatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional upper limit of normal (ULN)Xx_NEWLINE_xXCreatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine ? 1.5 × ULN or, for patients with creatinine levels above institutional upper limit of normal, creatinine clearance must be > 60 mL/min/1.73 m^2.Xx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal limits (creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal)Xx_NEWLINE_xXCreatinine less than institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x University of Iowa Hospitals and Clinics (UIHC) upper limit of normal or creatinine clearance of at least 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance > 60 mL/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXObtained within 30 days of registration: Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 x institutional upper limits of normal or for patients with creatinine levels above 1.5 x institutional normal: creatinine clearance >= 50 mL/min/1.73 m^2 by 24 hour urine collection or estimated creatinine clearance of >= 50 mL/min; for creatinine clearance estimation, the Cockcroft and Gault equation should be usedXx_NEWLINE_xXCreatinine =< 1.5 mg/dL, or creatinine clearance >= 30 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance > 45 mL/min/1.73 m^2, for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< IULN OR creatinine clearance >= 40 mL/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits, OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine < 2.0 mg/dL or creatinine clearance (Cockcroft) >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 x IULN OR creatinine clearance > 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine within normal institutional limits, or creatinine clearance (calculated by Cockcroft-Gault) >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine less than or equal to the institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine below institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits for age OR creatinine clearance >= 70 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< institutional ULN or creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine less than or equal to 1.5 times the ULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within institutional limits of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal obtained =<14 days prior to randomizationXx_NEWLINE_xXSerum creatinine within normal institutional limits or creatinine clearance at least 60 ml/min within 30 days prior to registrationXx_NEWLINE_xXCreatinine clearance >= 30 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXWithin 14 days of registration: Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 x the institutional upper limits of normal or corrected creatinine clearance of >= 50 mg/ml/hr/1.73 m^2 body surface area (BSA)Xx_NEWLINE_xXCreatinine =< institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXPHASE I: Creatinine between 0-1.3 mg/dL or creatinine clearance > 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normalXx_NEWLINE_xXPHASE II: Creatinine between 0-1.3 mg/dL or creatinine clearance > 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normalXx_NEWLINE_xXCreatinine =< institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine < 1.5 X institutional upper limit of normal OR creatinine clearance >= 30 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine up to 1.5 X ULN or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normalXx_NEWLINE_xXCreatinine ?1.5 x ULN or creatinine clearance >60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (as determined by Cockcroft-Gault equation).Xx_NEWLINE_xXSerum creatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine < 1.5 X institutional upper limit of normal OR calculated creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< institutional ULN or creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal or >= 50 mL/min 24-hour creatinine clearanceXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 40 mL/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine < 1.5 X institutional upper limit of normal OR creatinine clearance >= 60 mL/min for patients with creatinine levels above 1.5 X institutional upper limit of normalXx_NEWLINE_xXCreatinine within 1.5 x upper limit of normal, OR creatinine clearance > 60 mL/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXPART B: Creatinine =< 1.5 X ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 times institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 measured by 24-hour urine collectionXx_NEWLINE_xXCreatinine within 1.5 X normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal by Cockcroft-Gault equationXx_NEWLINE_xXCreatinine < 1.5 x institution upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< upper limit of normal (ULN) or creatinine clearance (either estimated or calculated) >= 60 mL/min/1.73 m for patients with creatinine levels above institutional normalXx_NEWLINE_xXPatients must have normal organ and marrow function as defined below: leukocytes ?3,000/mcL, absolute neutrophil count ?1,500/mcL, platelets ?100,000/mcL, total bilirubin within normal institutional limits, aspartate aminotransferase AST(SGOT)/ alanine aminotransferase ALT(SGPT) ?2.5 X institutional upper limit of normal, creatinine within normal institutional limits OR creatinine clearance ?60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal.Xx_NEWLINE_xXCreatinine < or equal to 1.5 x ULN or creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXREGISTRATION INCLUSION CRITERIA: Creatinine =< 1.5 institutional upper limits of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine ? 1.5 × ULN or creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal.Xx_NEWLINE_xXSerum creatinine =< the institutional upper limit of normal or creatinine clearance >= 40 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine ? 1.5 x ULN or creatinine clearance > 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine < 1.5 x institutional upper limit of normal or creatinine clearance >= 50 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limits of normal OR creatinine clearance of >= 50 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal by 24 hour urineXx_NEWLINE_xXNormal serum creatinine or creatinine clearance >= 60 ml/min/1.73 m^2Xx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 50mL/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x institutional ULN or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional ULNXx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x upper limit of normalXx_NEWLINE_xXObtained within 14 days prior to registration: Serum creatinine =< 1.5 x the institutional upper limits of normal or corrected creatinine clearance of >= 50 mg/ml/hr/1.73 m^2 body surface area (BSA)Xx_NEWLINE_xXcreatinine clearance > 60 mL/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine levels =< 1.5 x upper limit of normal (ULN) OR creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine less than the institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 × upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXWithin 14 days after subjects signed the treatment consent: Serum creatinine =< 1.5 mg/dl OR creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x normal institutional limits or creatinine clearance > 50mL/minXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with serum creatinine < 2 mg/mLXx_NEWLINE_xXCreatinine ? 2.0 mg/dl Or Creatinine clearance ? 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine less than institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above the institutional normalXx_NEWLINE_xXCreatinine < 1.5 x upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels >= 1.5 x upper limit of normalXx_NEWLINE_xXSerum creatinine clearance =< 1.5 x ULN or >= 60 mL/minute for subjects with creatinine levels > 1.5 x the institutional upper limit of normal (ULN)Xx_NEWLINE_xXCreatinine =< 1.5 mg/dL or creatinine clearance >= 50 mL/min for subjects with creatinine levels about institutional normalXx_NEWLINE_xXEXPANSION COHORT ONLY: Creatinine =< 1.5 mg/dL or creatinine clearance >= 50 mL/min for subjects with creatinine levels about institutional normalXx_NEWLINE_xXCreatinine =< institutional ULN or creatinine clearance >= 30 mL/min/1.73 m^2 for subjects with creatinine levels above institutional ULNXx_NEWLINE_xXCreatinine =< the institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine below or within the upper institutional limits of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 60 mL/min for patients with creatinine levels above 1.5 x institutional upper limit of normalXx_NEWLINE_xXCreatinine < 1.5 x upper limit of normal OR measured creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x upper limit of normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 x upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 X normal institutional limits or creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above normal institutional limit (a calculated one may be used)Xx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance > 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine OR creatinine clearance within normal institutional limits OR > 60 Ml/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXcreatinine clearance* >45 mL/min/1.73 m2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (as calculated by Cockcroft-Gault)Xx_NEWLINE_xXCreatinine within normal limits for the laboratory OR creatinine clearance >= 60 mL/min/1.73 m^2 (estimated glomerular filtration rate [eGFR]) for patients with creatinine levels above the ULN for the laboratoryXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limits of normal or creatinine clearance > 60 mg/min for subjects with creatinine levels >= 1.5 X upper limits of normalXx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance >= 60mL/min/1.73 m^2 for subject with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR calculated creatinine clearance >= 60 mL/min/1.73 m^2 for patients with levels above institutional normal using modified Cockcroft-GaultXx_NEWLINE_xXCreatinine =< 1.2 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine:\r\n* Creatinine levels within normal institutional limits (< 1.5 x ULN); or,\r\n* Creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXAcceptable renal function: • Serum creatinine ? 1.5 times the ULN, or calculated creatinine clearance ? 60 mL/min/1.73 m2 for patients with creatinine levels above 1.5 times the institutional normalXx_NEWLINE_xXCreatinine =< ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x institutional ULN or creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, obtained through calculated or measured creatinine clearanceXx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limits of normal OR creatinine clearance > 50 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 x institutional normalXx_NEWLINE_xXCreatinine within normal institutional limit for the reference lab OR creatinine clearance >= 60 mL/min/1.73 m^2 as calculated by Cockcroft-Gault formula for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within 1.5 x upper limit of normal OR creatinine clearance > 60 mL/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min for patients with creatinine levels above institutional normal, as determined by a measured 24-hour creatinine clearanceXx_NEWLINE_xXCreatinine =< institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 X upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine not to be above IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine < institutional upper limit of normal (ULN) OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels greater than ULNXx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN) or creatinine clearance >= 60 ml for patients with creatinine levels 1.5 times above institutional ULN (calculated based on age, weight and sex)Xx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal or creatinine clearance >= 60ml/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine < 1.5 X institution upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (unless due to lymphoma)Xx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x ULN OR calculated or measured creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine above institutional normalXx_NEWLINE_xXCreatinine less than the institutional upper limit of normal OR creatinine clearance >= 50 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine < 1.5 x institutional upper limit or normal OR creatinine clearance >= 60 mL/min for patients with creatinine levels above 1.5 x institutional upper limit of normalXx_NEWLINE_xXCreatinine =< institution upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine < 1.5 x ULN or creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dl OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above 2.0Xx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< institutional upper limit of normal or creatinine clearance (either estimated or calculated) >= 60 mL/min/1.73 m for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine below 1.5 X upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normalXx_NEWLINE_xXCreatinine =< 2 X institutional ULN OR creatinine clearance >= 30 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN OR creatinine clearance >= 60 ml/min for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine ?1.5 x ULN or creatinine clearance > 60 mL/min/1.73 m^2 for subjects with creatinine levels >1.5 x ULNXx_NEWLINE_xXCreatinine < 1.5 X institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine < 1.5 X institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 x upper normal limits OR creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, as calculated by the Cockcroft Gault formulaXx_NEWLINE_xXCreatinine within 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine level above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 X institutional upper limit of normal or creatinine clearance less than 60 ml/minXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within institutional limits of normal or creatinine clearance >= 60 ml/min/m^2 if elevated creatinineXx_NEWLINE_xXSerum creatinine less than 1.5 x upper limit of normal (ULN), OR 24-hour creatinine clearance = or 60 mL/min for subject with creatinine levels more than 1.5 x ULN; (Note: creatinine clearance need not be determined if the\r\nbaseline serum creatinine is within normal limits; creatinine clearance should be determined per institutional standard)Xx_NEWLINE_xXSerum creatinine =< 1.5 x IULN OR creatinine clearance by Cockcroft-Gault >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x IULNXx_NEWLINE_xXCreatinine < 1.5 x upper limit of normal (ULN) or creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< IULN OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance or calculated >= 60 mL/min/1.73 m^2 for patients with creatinine clearance or estimated creatinine levels above institutional glomerular filtration rate (eGFR) normalXx_NEWLINE_xXCreatinine clearance ? 15 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 2.0 or creatinine clearance > 30 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< institutional upper limit of normal OR creatinine clearance >= 30 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 70 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine less than upper limit of normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine within normal institutional limits or less than the lower limit of normal institutional limits; or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 if serum creatinine > institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 50 ml/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine =< 1.5 times institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine £ 1.5 ´ ULN or creatinine clearance > 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 55 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 30 mL/min/1.73 m^2 for participants with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal; (calculated via Cockcroft-Gault equation)Xx_NEWLINE_xXSURGICAL ARM: creatinine within normal institutional limits or creatinine clearance > 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal limitXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits or\r\n* Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine below upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSubject must have adequate renal function with creatinine within normal institutional limits or creatinine clearance > 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance ? 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (calculated via Cockcroft-Gault equation)Xx_NEWLINE_xXCreatinine within 1.5 x upper limit of normal (ULN) OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine ? 1.5 x ULN or CrCl > 60 mL/min/1.73 m2 for patients with serum creatinine levels above institutional 1.5 x ULNXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance >= 30 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (calculated via Cockcroft-Gault equation)Xx_NEWLINE_xXCreatinine ? 1.5 mg/dL or creatinine clearance > 60 mL/min/1.73 m2 for subjects with creatinine levels above institutional normal.Xx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance > 60 mL/min/1.73 m2 for subjects with creatinine levels above institutional normal.Xx_NEWLINE_xXCreatinine within normal institutional limits or creatinine clearance > 60 mL/min/1.73 m2 for subjects with creatinine levels above institutional normal.Xx_NEWLINE_xXCreatinine =< 1.5 X institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (calculated with the Cockcroft-Gault Equation in EPIC)Xx_NEWLINE_xX