Serum creatinine of =< 1.5 mg/dL; if creatinine > 1.5 mg/dL, creatinine clearance must be >= 60 mL/minuteXx_NEWLINE_xXA serum creatinine based on age/gender as follows:\r\n* =< 0.6 mg/dL (patients age 1 to < 2 years)\r\n* =< 0.8 mg/dL (patients age 2 to < 6 years)\r\n* =< 1 mg/dL (patients age 6 to < 10 years)\r\n* =< 1.2 mg/dL (patients age 10 to < 13 years)\r\n* =< 1.4 mg/dL (female patients age >= 13 years)\r\n* =< 1.5 mg/dL (male patients age 13 to < 16 years)\r\n* =< 1.7 mg/dL (male patients age >= 16 years)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age 1 to < 2 years: 0.6 mg/dL\r\n* Age 2 to < 6 years: 0.8 mg/dL\r\n* Age 6 to < 10 years: 1 mg/dL\r\n* Age 10 to < 13 years: 1.2 mg/dL\r\n* Age 13 to < 16 years: 1.5 mg/dL (males), 1.4 mg/dL (females)\r\n* Age >= 16 years: 1.7 mg/dL (males), 1.4 mg/dL (females)Xx_NEWLINE_xXSerum creatinine =< 1.5 x mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 50 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age: 6 months to < 1 years maximum serum creatinine (mg/dL): male: 0.5; female: 0.5\r\n* Age: 1 to < 2 years maximum serum creatinine (mg/dL): male: 0.6; female: 0.6\r\n* Age: 2 to < 6 years maximum serum creatinine (mg/dL): male: 0.8; female: 0.8\r\n* Age: 6 to < 10 years maximum serum creatinine (mg/dL): male: 1; female: 1\r\n* Age: 10 to < 13 years maximum serum creatinine: (mg/dL): male: 1.2; female: 1.2\r\n* Age: 13 to < 16 years maximum serum creatinine: (mg/dL): male: 1.5; female: 1.4\r\n* Age: >= 16 years maximum serum creatinine: (mg/dL) male: 1.7; female: 1.4Xx_NEWLINE_xXBilirubin =< 1.5 mg/dL (or =< 3.0 mg/dL if due to Gilbert's syndrome) within 28 days prior to registrationXx_NEWLINE_xXBilirubin =< 1.5 mg/dL (or =< 3.0 mg/dL if due to Gilbert's syndrome or if liver metastases are present)Xx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine < 2.0 mg/dLXx_NEWLINE_xXSerum creatinine < 2 mg/dl; NOTE: the above stipulation for normal hepatic function does not apply if liver dysfunction is due to leukemia infiltrationXx_NEWLINE_xXObtained =< 48 hours prior to registration: Serum creatinine =< 2.0 mg/dlXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or normal serum creatinine based on age/gender as follows:\r\n* 2 to < 6 years; 0.8 mg/dL male; 0.8 mg/dL female\r\n* 6 to < 10 years; 1 mg/dL male; 1 mg/dL female\r\n* 10 to < 13 years; 1.2 mg/dL male; 1.2 mg/dL female\r\n* 13 to < 16 years; 1.5 mg/dL male; 1.4 mg/dL female\r\n* >= 16 years; 1.5 mg/dL male; 1.4 mg/dL femaleXx_NEWLINE_xXWithin 14 days of registration: Serum creatinine < 2.0 mg/dL (176.8 umol/liter)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* 1 month to < 6 months old: 0.4 mg/dl (male), 0.4 mg/dl (female)\r\n* 6 months to < 1 year old: 0.5 mg/dl (male), 0.5 mg/dl (female)\r\n* 1 to < 2 years old: 0.6 mg/dl (male), 0.6 mg/dl (female)\r\n* 2 to < 6 years old: 0.8 mg/dl (male), 0.8 mg/dl (female)\r\n* 6 to < 10 years old: 1 mg/dl (male), 1 mg/dl (female)\r\n* 10 to < 13 years old: 1.2 mg/dl (male), 1.2 mg/dl (female)\r\n* 13 to < 16 years old: 1.5 mg/dl (male), 1.4 mg/dl (female)\r\n* >= 16 years old: 1.7 mg/dl (male), 1.4 mg/dl (female)\r\n* Patients with an elevated serum creatinine due to obstructive hydronephrosis secondary to tumor are still eligible; however, patients with urinary tract obstruction by tumor must have unimpeded urinary flow established via diversion (i.e. percutaneous nephrostomies or ureteric stents) of the urinary tractXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age < 6 months: Maximum serum creatinine (mg/dL): 0.4 for males and females\r\n* Age 6 months to < 1 year: Maximum serum creatinine (mg/dL): 0.5 for males and females\r\n* Age 1 to < 2 years: Maximum serum creatinine (mg/dL): 0.6 for males and females\r\n* Age 2 to < 6 years: Maximum serum creatinine (mg/dL): 0.8 for males and females\r\n* Age 6 to < 10 years: Maximum serum creatinine (mg/dL): 1 for males and females\r\n* Age 10 to < 13 years: Maximum serum creatinine (mg/dL): 1.2 for males and females\r\n* Age 13 to < 16 years: Maximum serum creatinine (mg/dL): 1.5 for males and 1.4 for females\r\n* Age >= 16 years: Maximum serum creatinine (mg/dL): 1.7 for males and 1.4 for femalesXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* 1 to < 2 years: =< 0.6 mg/dL\r\n* 2 to < 6 years: =< 0.8 mg/dL\r\n* 6 to < 10 years: =< 1 mg/dL\r\n* 10 to < 13 years: =< 1.2 mg/dL\r\n* 13 to < 16 years: =< 1.5 mg/dL (males) and =< 1.4 mg/dL (females)\r\n* >= 16 years: =< 1.7 mg/dL (males) and =< 1.4 mg/dL (females)Xx_NEWLINE_xXPatients with serum creatinine > 3.0 mg/dL and patients on active dialysis for renal dysfunction are excludedXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* 2 to < 6 years: male 0.8 mg/dL, female 0.8 mg/dL\r\n* 6 to < 10 years: male 1 mg/dL, female 1 mg/dL\r\n* 10 to < 13 years: male 1.2 mg/dL, female 1.2 mg/dL\r\n* 13 to < 16 years: male 1.5 mg/dL, female 1.4 mg/dL\r\n* >= 16 years: male 1.7 mg/dL, female 1.4 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* 3 to < 6 years of age: maximum (max) serum creatinine 0.8 mg/dL (males and females)\r\n* 6 to < 10 years of age: max serum creatinine 1 mg/dL (males and females)\r\n* 10 to < 13 years of age: max serum creatinine 1.2 mg/dL (males and females)\r\n* 13 to < 16 years of age: max serum creatinine 1.5 md/dL (males) and 1.4 md/dL (females)\r\n* >= 16 years of age: max serum creatinine 1.7 mg/dL (males) and 1.4 mg/dL (females)\r\n** The threshold creatinine values were derived from the Schwartz formula for estimating GFR utilizing child length and stature data published by the Centers for Disease Control and Prevention (CDC)Xx_NEWLINE_xXSerum creatinine within normal limits based on age/gender, as follows:\r\n* 1 to < 2 years: maximum serum creatinine 0.6 mg/dL (both male and female)\r\n* 2 to < 6 years: maximum serum creatinine 0.8 mg/dL (both male and female)\r\n* 6 to < 10 years: maximum serum creatinine 1 mg/dL (both male and female)\r\n* 10 to < 13 years: maximum serum creatinine 1.2 mg/dL (both male and female)\r\n* 13 to < 16 years: maximum serum creatinine 1.5 mg/dL (male), 1.4 mg/dL (female)\r\n* >= 16 years: maximum serum creatinine 1.7 mg/dL (male), 1.4 mg/dL (female)Xx_NEWLINE_xXSerum creatinine < 2.0 mg/dlXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL within 14 days prior to study entryXx_NEWLINE_xXPatients must have serum creatinine =< 1.5 mg/dl within 14 days prior to registrationXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dl within 14 days prior to registrationXx_NEWLINE_xXRegistration Step 3 – Maintenance: Patients must have serum creatinine =< 1.5 mg/dl within 14 days prior to registrationXx_NEWLINE_xXCreatinine =< 1.7 mg/dlXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* 2 to < 6 years of age\r\n** Male and female: 0.8 (maximum serum creatinine [mg/dL])\r\n* 6 to < 10 years of age\r\n** Male and female: 1 (maximum serum creatinine [mg/dL])\r\n* 10 to < 13 years of age\r\n** Male and female: 1.2 (maximum serum creatinine [mg/dL])\r\n* 13 to < 16 years of age\r\n** Male 1.5 (maximum serum creatinine [mg/dL])\r\n** Female: 1.4 (maximum serum creatinine [mg/dL])\r\n* >= 16 years of age\r\n** Male: 1.7 (maximum serum creatinine [mg/dL])\r\n** Female: 1.4 (maximum serum creatinine [mg/dL])Xx_NEWLINE_xXA serum creatinine based on age/gender as follows:\r\n* Age 1 to < 2 years: maximum serum creatinine 0.6 mg/dL for male and 0.6 mg/dL for female\r\n* Age 2 to < 6 years: maximum serum creatinine 0.8 mg/dL for male and 0.8 mg/dL for female\r\n* Age 6 to < 10 years: maximum serum creatinine 1 mg/dL for male and 1 mg/dL for female\r\n* Age 10 to < 13 years: maximum serum creatinine 1.2 mg/dL for male and 1.2 mg/dL for female\r\n* Age 13 to < 16 years: maximum serum creatinine 1.5 mg/dL for male and 1.4 mg/dL for female\r\n* Age >= 16 years: maximum serum creatinine 1.7 mg/dL for male and 1.4 mg/dL for femaleXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age: 1 to < 2 years; maximum serum creatinine (mg/dL): male 0.6; female 0.6\r\n* Age: 2 to < 6 years; maximum serum creatinine (mg/dL): male 0.8; female 0.8\r\n* Age: 6 to < 10 years; maximum serum creatinine (mg/dL): male 1; female 1\r\n* Age: 10 to < 13 years; maximum serum creatinine (mg/dL): male 1.2; female 1.2\r\n* Age: 13 to < 16 years; maximum serum creatinine (mg/dL): male 1.5; female 1.4\r\n* Age: >= 16 years; maximum serum creatinine (mg/dL): male 1.7; female 1.4Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age: 1 to < 2 years; maximum serum creatinine (mg/dL): male 0.6; female 0.6\r\n* Age: 2 to < 6 years; maximum serum creatinine (mg/dL): male 0.8; female 0.8\r\n* Age: 6 to < 10 years; maximum serum creatinine (mg/dL): male 1; female 1\r\n* Age: 10 to < 13 years; maximum serum creatinine (mg/dL): male 1.2; female 1.2\r\n* Age: 13 to < 16 years; maximum serum creatinine (mg/dL): male 1.5; female 1.4\r\n* Age: >= 16 years; maximum serum creatinine (mg/dL): male 1.7; female 1.4Xx_NEWLINE_xXA serum creatinine based on age/gender as follows:\r\n* Age 1 to < 2 years: maximum serum creatinine 0.6 mg/dL for male and 0.6 mg/dL for female\r\n* Age 2 to < 6 years: maximum serum creatinine 0.8 mg/dL for male and 0.8 mg/dL for female\r\n* Age 6 to < 10 years: maximum serum creatinine 1 mg/dL for male and 1 mg/dL for female\r\n* Age 10 to < 13 years: maximum serum creatinine 1.2 mg/dL for male and 1.2 mg/dL for female\r\n* Age 13 to < 16 years: maximum serum creatinine 1.5 mg/dL for male and 1.4 mg/dL for female\r\n* Age >= 16 years: maximum serum creatinine 1.7 mg/dL for male and 1.4 mg/dL for femaleXx_NEWLINE_xXA serum creatinine based on age/gender as follows:\r\n* Age: 1 to < 2 years; maximum serum creatinine (mg/dL); male: 0.6 female: 0.6\r\n* Age: 2 to < 6 years; maximum serum creatinine (mg/dL); male: 0.8 female: 0.8\r\n* Age: 6 to < 10 years; maximum serum creatinine (mg/dL); male: 1 female: 1\r\n* Age: 10 to < 13 years; maximum serum creatinine (mg/dL); male: 1.2 female: 1.2\r\n* Age: 13 to < 16 years; maximum serum creatinine (mg/dL); male: 1.5 female: 1.4\r\n* Age: >= 16 years; maximum serum creatinine (mg/dL); male: 1.7 female: 1.4Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age: 1 to < 2 years; maximum serum creatinine (mg/dL): male 0.6; female 0.6\r\n* Age: 2 to < 6 years; maximum serum creatinine (mg/dL): male 0.8; female 0.8\r\n* Age: 6 to < 10 years; maximum serum creatinine (mg/dL): male 1; female 1\r\n* Age: 10 to < 13 years; maximum serum creatinine (mg/dL): male 1.2; female 1.2\r\n* Age: 13 to < 16 years; maximum serum creatinine (mg/dL): male 1.5; female 1.4\r\n* Age: >= 16 years; maximum serum creatinine (mg/dL): male 1.7; female 1.4Xx_NEWLINE_xXSerum creatinine >2.0 mg/dL.Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL (133 umol/L)Xx_NEWLINE_xXPatients must have adequate renal function defined as < 1.5 x normal serum creatinine as adjusted for age: \r\nAge: < 5 years; maximum serum creatinine: 0.8 mg/dL \r\nAge: > 5 and < 10 years; maximum serum creatinine: 1.0 mg/dL\r\nAge: > 10 and < 15 years; maximum serum creatinine: 1.2 mg/dL\r\nAge: > 15 years; maximum serum creatinine: 1.5 mg/dLXx_NEWLINE_xXA serum creatinine based on age/gender as follows:\r\n* Age: 1 to < 2 years; maximum serum creatinine (mg/dl): 0.6\r\n* Age: 2 to < 6 years; maximum serum creatinine (mg/dl): 0.8\r\n* Age: 6 to < 10 years; maximum serum creatinine (mg/dl): 1.0\r\n* Age: 10 to < 13 years; maximum serum creatinine (mg/dl): 1.2\r\n* Age: 13 to < 16 years; maximum serum creatinine (mg/dl): 1.5 (male) 1.4 (female)\r\n* Age: >= 16 years; maximum serum creatinine (mg/dl): 1.7 (male) 1.4 (female)Xx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXWithin 14 days of treatment initiation:\r\nAlbumin >= 2.5 mg/dLXx_NEWLINE_xXSerum creatinine < 2.0 mg/dlXx_NEWLINE_xXCreatinine < 2 mg/dLXx_NEWLINE_xX6 months to 3 years of age: serum creatinine ? 0.4mg/dLXx_NEWLINE_xX3 to 13 years of age: serum creatinine ? 0.7mg/dLXx_NEWLINE_xXSerum creatinine concentration based on age as in the table below or glomerular filtration rate (GFR) > 70 ml/min/1.73 m^2\r\n* =< 5 years, 0.8 mg/dL\r\n* 5 < age =< 10 years, 1.0 mg/dL\r\n* 10 < age =< 15 years, 1.2 mg/dL\r\n* > 15 years, 1.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.5 mg/dL x ULNXx_NEWLINE_xXCreatinine less than or equal to 2.0 mg/dLXx_NEWLINE_xXCreatinine ?1.5mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine < 2 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL ORXx_NEWLINE_xXSerum creatinine < 2.0 mg/dLXx_NEWLINE_xXSerum creatinine >2.5 mg/dLXx_NEWLINE_xXSerum calcium >11 mg/dLXx_NEWLINE_xXCreatinine < 1.5 mg/dlXx_NEWLINE_xXSerum creatinine ? 2.0 mg/dLXx_NEWLINE_xXHave a serum creatinine level ?1.8 mg/dLXx_NEWLINE_xXCreatinine: within age adjusted normal institutional limits:\r\n* Age =< 5 years - maximum serum creatinine 0.8 mg/dL\r\n* Age 5 years < age =< 10 years - maximum serum creatinine 1.0 mg/dL\r\n* Age > 10 years - maximum serum creatinine 1.2 mg/dL ORXx_NEWLINE_xXCreatinine =< 2 mg/dLXx_NEWLINE_xXTotal bilirubin =< 1.5 mg/dL or < 2 mg/dL if attributable to hepatic infiltration by neoplastic diseaseXx_NEWLINE_xXSerum creatinine > 2 mg/dLXx_NEWLINE_xXSerum creatinine ? 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 1.4 mg/dlXx_NEWLINE_xXSerum creatinine ? 3 mg/dLXx_NEWLINE_xXAdequate Renal and Metabolic Function defined as creatinine clearance or radioisotope Glomerular filtration rate (GFR) >= 70 millilitre (mL)/ (min)/1.73 meter (m)^2 or A serum creatinine based on age/gender as follows, age 1 to < 2 years (male-0.6 milligrams (mg)/dL, female-0.6 mg/dL), age 2 to < 6 years (male-0.8 mg/dL, female-0.8 mg/dL), age 6 to < 10 years (male-1 mg/dL, female-1 mg/dL), age 10 to < 13 years (male-1.2 mg/dL, female-1.2 mg/dL), age 13 to < 16 years (male-1.5 mg/dL, female-1.4 mg/dL), age >= 16 years (male-1.7 mg/dL, female-1.4 mg/dL), urine creatinine ratio of <1 or a urinalysis that is negative for protein; or, 24-hour urine protein level < 1000 mg/dL, adequate thyroid function ,no more than Grade 1 abnormalities of potassium, calcium (confirmed by ionized calcium), magnesium and phosphorous.Xx_NEWLINE_xXA serum creatinine based on age/gender as follows:\r\n* Age: 1 to < 2 years; Male: 0.6 mg/dL; Female: 0.6 mg/dL\r\n* Age: 2 to < 6 years; Male: 0.8 mg/dL; Female: 0.8 mg/dL\r\n* Age: 6 to < 10 years; Male: 1 mg/dL; Female: 1 mg/dL\r\n* Age: 10 to < 13 years; Male: 1.2 mg/dL; Female: 1.2 mg/dL\r\n* Age: 13 to < 16 years; Male: 1.5 mg/dL; Female: 1.4 mg/dL\r\n* Age: >= 16 years; Male: 1.7 mg/dL; Female: 1.4 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows: \r\n* 1 to < 2 years: 0.6 mg/dL (male), 0.6 mg/dL (female)\r\n* 2 to < 6 years: 0.8 mg/dL (male), 0.8 mg/dL (female)\r\n* 6 to < 10 years: 1 mg/dL (male), 1 mg/dL (female)\r\n* 10 to < 13 years: 1.2 mg/dL (male), 1.2 mg/dL (female)\r\n* 13 to < 16 years: 1.5 mg/dL (male), 1.4 mg/dL (female)\r\n* >= 16 years: 1.7 mg/dL (male), 1.4 mg/dL (female)Xx_NEWLINE_xXA serum creatinine based on age/gender as follows:\r\n* 0.8 mg/dL (3 to < 6 years of age)\r\n* 1.0 mg/dL (6 to < 10 years of age)\r\n* 1.2 mg/dL (10 to < 13 years of age)\r\n* 1.5 mg/dL (male) or 1.4 mg/dl (female) (13 to < 16 years of age)\r\n* 1.7 mg/dL (male) or 1.4 mg/dl (female) (>= 16 years of age)Xx_NEWLINE_xXCreatinine clearance or nuclear glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age as follows:\r\n=< 5 years: maximum serum creatinine 0.8 mg/dL\r\n5 years < age =< 10 years: maximum serum creatinine 1 mg/dL\r\n10 years < age =< 15 years: maximum serum creatinine 1.2 mg/dL \r\n> 15 years: maximum serum creatinine 1.5 mg/dLXx_NEWLINE_xXDocumented within 14 days of registration: Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age as follows:\r\n* =< 5 years: maximum serum creatinine 0.8 mg/dL\r\n* > 5 but =< 10 years: maximum serum creatinine 1 mg/dL\r\n* > 10 but =< 15 years: maximum serum creatinine 1.2 mg/dL\r\n* > 15 years: maximum serum creatinine 1.5 mg/dLXx_NEWLINE_xXCreatinine ? 1.5 mg/dlXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum bilirubin must be ? 2.0 mg/dlXx_NEWLINE_xXWithin 14 days prior to registration: Serum creatinine =< 1.5 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine ? 2.5 mg/dl,Xx_NEWLINE_xXHave adequate renal function (Serum creatinine <3 mg/dL).Xx_NEWLINE_xXSerum creatinine based on age/gender as noted below; patients that do not meet the criteria below but have a 24 hour creatinine clearance or glomerular filtration rate (GFR) (radioisotope or iothalamate) >= 70 ml/min/1.73 m^2 are eligible\r\n* 1 to < 2 years: 0.6 mg/dl\r\n* 2 to < 6 years: 0.8 mg/dl\r\n* 6 to < 10 years: 1 mg/dl\r\n* 10 to < 13 years: 1.2 mg/dl\r\n* 13 to < 16 years: 1.5 mg/dl (male), 1.4 mg/dl (female)\r\n* >= 16 years: 1.7 mg/dl (male), 1.4 mg/dl (female)Xx_NEWLINE_xXINCLUSION CRITERIA FOR STRATUM C: Serum creatinine based on age/gender as noted below; patients that do not meet the criteria below but have a 24 hour creatinine clearance or GFR (radioisotope or iothalamate) >= 70 ml/min/1.73 m^2 are eligible\r\n* 1 to < 2 years: 0.6 mg/dl\r\n* 2 to < 6 years: 0.8 mg/dl\r\n* 6 to < 10 years: 1 mg/dl\r\n* 10 to < 13 years: 1.2 mg/dl\r\n* 13 to < 16 years: 1.5 mg/dl (male), 1.4 mg/dl (female)\r\n* >= 16 years: 1.7 mg/dl (male), 1.4 mg/dl (female)Xx_NEWLINE_xXSerum creatinine =< 2.0 x mg/dLXx_NEWLINE_xXNormal creatinine OR creatinine clearance >= 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal\r\n* Age =< 5 years; maximum serum creatinine 0.8 mg/dL\r\n* Age 5 < age =< 10 years; maximum serum creatinine 1.0 mg/dL\r\n* Age > 10 years; maximum serum creatinine 1.2 mg/dLXx_NEWLINE_xXCreatinine < 2.0 mg/dlXx_NEWLINE_xXClinically significant renal disease (creatinine > 2.0 mg/dL, urea > 100 mg/dL)Xx_NEWLINE_xXTotal bilirubin of ? 1.5 mg/dL or ? 2.0 mg/dL for subjects with liver metastasis.Xx_NEWLINE_xXCreatinine > 1.5 mg/dl at the present time; patients with a known history of creatinine > 1.5 mg/dl must have a current estimated creatinine clearance of > 40 ml/minXx_NEWLINE_xXCreatinine > 2.0 mg/dl at the present time; patients with a known history of creatinine > 1.5 mg/dl must have a current estimated creatinine clearance > 40 ml/minXx_NEWLINE_xXCreatinine 0.6-1.3: MG/DLXx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXSerum creatinine less than or equal to 1.6 mg/dlXx_NEWLINE_xXSerum bilirubin < 2 mg/dLXx_NEWLINE_xXCreatinine (Cr) > 2 mg/dL at the screening visitXx_NEWLINE_xXSerum bilirubin values < 2.0 mg/dLXx_NEWLINE_xXSerum creatinine < 2.5 mg/dLXx_NEWLINE_xXA baseline creatinine reported as > 2.0 mg/dLXx_NEWLINE_xXAdequate renal function defined as: a serum creatinine that is =< maximum based on age/gender\r\nAge: 1 to < 2 years; maximum serum creatinine (mg/dL): 0.6\r\nAge: 2 years < 6 years; maximum serum creatinine (mg/dL): 0.8\r\nAge: 6 to < 10 years; maximum serum creatinine (mg/dL): 1.0\r\nAge: 10 to < 13 years; maximum serum creatinine (mg/dL): 1.2\r\nAge: 13 to < 16 years; maximum serum creatinine (mg/dL):1.5 (male) 1.4 (female)\r\nAge: > 16 years; maximum serum creatinine (mg/dL): 1.7 (male) 1.4 (female)Xx_NEWLINE_xXRETREATMENT WITH MODIFIED T-CELLS INCLUSION CRITERIA: Adequate renal function defined as: a serum creatinine that is =< maximum based on age/gender\r\nAge: 1 to < 2 years; maximum serum creatinine (mg/dL): 0.6\r\nAge: 2 years < 6 years; maximum serum creatinine (mg/dL): 0.8\r\nAge: 6 to < 10 years; maximum serum creatinine (mg/dL): 1.0\r\nAge: 10 to < 13 years; maximum serum creatinine (mg/dL): 1.2\r\nAge: 13 to < 16 years; maximum serum creatinine (mg/dL):1.5 (male) 1.4 (female)\r\nAge: > 16 years; maximum serum creatinine (mg/dL): 1.7 (male) 1.4 (female)Xx_NEWLINE_xXAdequate renal function with serum creatinine ?2.5 mg/dLXx_NEWLINE_xXSerum creatinine =< to 1.6 mg/dlXx_NEWLINE_xXSerum creatinine levels =< 2 mg/dLXx_NEWLINE_xXSerum bilirubin levels =< 1.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum phosphorus >= 2.3 and < 4.8 mg/dLXx_NEWLINE_xXSerum calcium > 8.5 and < 10.5 mg/dLXx_NEWLINE_xXPART I: Creatinine =< 1.5 mg/dLXx_NEWLINE_xXPART II: Creatinine =< 1.5 mg/dLXx_NEWLINE_xXRenal: Glomerular filtration rate > 50 cc/min/1.73 m^2, OR serum creatinine based on age as follows:\r\n* 0.6 mg/dL (age 1 to 2 years)  \r\n* 0.8 mg/dL (age 2 to 6 years) \r\n* 1 mg/dL (age 6 to 10 years) \r\n* 1.2 mg/dL (age 10 to < 13 years)\r\n* 1.5 mg/dL (male); 1.4 mg/dL (female) (age 13 to 16 years)\t\r\n* 1.7 mg/dL (male); 1.4 mg/dL (female) (age > 16 years)Xx_NEWLINE_xXSerum creatinine < 1.5 mg/dL OR if serum creatinine > 1.5 mg/dL then calculate creatinine clearance (CrCL) > 30 mL/minXx_NEWLINE_xXSerum creatinine < 1.5 mg/dlXx_NEWLINE_xXSerum bilirubin =< 1.5 mg/dLXx_NEWLINE_xXSerum creatinine less than or equal to 1.6 mg/dlXx_NEWLINE_xXSerum creatinine < 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 1.5 mg/dL is recommended; however, institutional norms are acceptableXx_NEWLINE_xXCreatinine clearance/glomerular filtration rate (GFR) > 70 cc/min/1.73 m^2 or serum creatinine based on age/gender as follows:\r\n* 1 month to < 6 months: 0.4 mg/dL\r\n* 6 months to < 1 year: 0.5 mg/dL\r\n* 1 to < 2 years: 0.6 mg/dL\r\n* 6 to < 10 years: 0.8 mg/dL\r\n* 10 to < 13 years: 1 mg/dL\r\n* 13 to < 16 years: 1.5 (male), 1.4 (female)\r\n* >= 16 years: 1.7 (male), 1.4 (female)Xx_NEWLINE_xXSerum creatinine less than or equal to 1.6 mg/dlXx_NEWLINE_xXCreatinine =< 1.5 mg/dL ORXx_NEWLINE_xXSerum creatinine =< 1.6 mg/dl.Xx_NEWLINE_xXAdequate renal function defined as glomerular filtration rate ? 60 cc/min/1.73 m^2 or serum creatinine based on age as follows:\r\n* Age: < 6 months; maximum serum creatinine (mg/dL): 0.4 (male, female)\r\n* Age: 6 months to < 1 year; maximum serum creatinine (mg/dL): 0.5 (male, female)\r\n* Age: 1 to < 2 years; maximum serum creatinine (mg/dL): 0.6 (male, female)\r\n* Age: 2 to < 6 years; maximum serum creatinine (mg/dL): 0.8 (male, female)\r\n* Age: 6 to < 10 years; maximum serum creatinine (mg/dL): 1 (male, female)\r\n* Age: 10 to < 13 years; maximum serum creatinine (mg/dL): 1.2 (male, female)\r\n* Age: 13 to < 16 years; maximum serum creatinine (mg/dL): 1.5 (male), 1.4 (female)\r\n* Age: ? 16 years; maximum serum creatinine (mg/dL): 1.7 (male), 1.4 (female)Xx_NEWLINE_xXARM I&II: Creatinine =< 1.7 mg/dlXx_NEWLINE_xXPatients must have a serum bilirubin =< 2.0 mg/dlXx_NEWLINE_xXCreatinine less than or equal to 2.0 mg/dL (unless considered tumor related)Xx_NEWLINE_xXSerum creatinine ? 2.0 mg/dlXx_NEWLINE_xXThe patient has a serum creatinine value greater than 1.5 mg/dLXx_NEWLINE_xXCreatinine > 1.5 mg/dLXx_NEWLINE_xXCreatinine within for age and laboratory normal ranges OR creatinine clearance ? 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal\r\n* ? 5 years: maximum serum creatinine (mg/dL) ? 0.8\r\n* 5 years < age ? 10 years: maximum serum creatinine (mg/dL) ? 1.0\r\n* > 10 years: maximum serum creatinine (mg/dL) ? 1.2Xx_NEWLINE_xXSerum calcium =< 12.0 mg/dLXx_NEWLINE_xXSerum phosphate less than 2.0 mg/dLXx_NEWLINE_xXPlatelet count ? 100,000/mm3 (transfusion independent, defined as not receiving platelet transfusions for at least 7 days prior to enrollment). Renal Function: • Creatinine clearance or radioisotope glomerular filtration rate (GFR) ? 70mL/min/1.73 m2 or normal serum creatinine based on age as shown below or GFR > 70ml/min/1.73m^2: Age < 5 years: 0.8 mg/dL maximum Age 5 to < 10 years: 1.0 mg/dL maximum Age 10 to < 15 years: 1.2 mg/dL maximum Age > 15 years: 1.5 mg/dL maximum Liver Function:Xx_NEWLINE_xXSerum creatinine less than or equal to 1.6 mg/dlXx_NEWLINE_xXCreatinine < 1.6 mg/dLXx_NEWLINE_xXResearch participant serum creatinine < 1.8 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* 1 to < 2 years: 0.6 mg/dL for males and females\r\n* 2 to < 6 years: 0.8 mg/dL for males and females\r\n* 6 to < 10 years: 1.0 mg/dL for males and females\r\n* 10 to < 13 years: 1.2 mg/dL for males and females\r\n* 13 to < 16 years: 1.5 mg/dL for males and 1.4 mg/dL for females\r\n* > = 16 years: 1.7 mg/dL for males and 1.4 mg/dL for femalesXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age: 1 to < 2 years; maximum serum creatinine (mg/dL): male 0.6; female 0.6\r\n* Age: 2 to < 6 years; maximum serum creatinine (mg/dL): male 0.8; female 0.8\r\n* Age: 6 to < 10 years; maximum serum creatinine (mg/dL): male 1; female 1\r\n* Age: 10 to < 13 years; maximum serum creatinine (mg/dL): male 1.2; female 1.2\r\n* Age: 13 to < 16 years; maximum serum creatinine (mg/dL): male 1.5; female 1.4\r\n* Age: >= 16 years; maximum serum creatinine (mg/dL): male 1.7; female 1.4Xx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73m^2 or a serum creatinine based on age as follows, within 14 days of registration and within 7 days of the start of treatment:\t\t\t\r\n* =< 5 years: 0.8 mg/dL\r\n* > 5 years but =< 10 years: 1 mg/dL\r\n* > 10 years but =< 15 years: 1.2 mg/dL\r\n* > 15 years: 1.5 mg/dLXx_NEWLINE_xXTo be performed within 14 days prior to day 1 of protocol therapy: creatinine =< 2.5 mg/dLXx_NEWLINE_xXCreatinine (Cr) > 2 mg/dL at the screening visitXx_NEWLINE_xXWithin 4 weeks of day 1: Creatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) > 70 mL/min/1.73 m^2, or a serum creatinine based on age/gender as follows:\r\n* Age 1 to < 2 years maximum serum creatinine (mg/dL) 0.6 (male); 0.6 (female)\r\n* Age 2 to < 6 years maximum serum creatinine (mg/dL) 0.8 (male); 0.8 (female)\r\n* Age 6 to < 10 years maximum serum creatinine (mg/dL) 1 (male); 1 (female)\r\n* Age 10 to < 13 years maximum serum creatinine (mg/dL) 1.2 (male); 1.2 (female)\r\n* Age 13 to < 16 years maximum serum creatinine (mg/dL) 1.5 (male); 1.4 (female)\r\n* Age >=16 years maximum serum creatinine (mg/dL) 1.7 (male) 1.4 (female)Xx_NEWLINE_xXSerum creatinine that is =< 1.5 X upper limit of normal (ULN) based on age/gender as listed below:\r\n* Age 1 to < 2 years, male 0.6 mg/dL, female 0.6 mg/dL\r\n* Age 2 years < 6 years, male 0.8 mg/dL, female 0.8 mg/dL\r\n* Age 6 to < 10 years, male 1.0 mg/dL, female 1.0 mg/dL\r\n* Age 10 to < 13 years, male 1.2 mg/dL, female 1.2 mg/dL\r\n* Age 13 to < 16 years, male 1.5 mg/dL, female 1.4 mg/dL\r\n* Age > 16 years, male 1.7 mg/dL, female 1.4 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL.Xx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.6 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dl (prior to biopsy)Xx_NEWLINE_xXMagnesium > 1.2 and < 2.5 mg/dL.Xx_NEWLINE_xXPatients have normal organ function: Hemoglobin ? 8.5 gm/dL, Platelets ? 50,000 /µL, Creatinine ? 2 mg/dL, AST and ALT < 10 X upper normal limit of the current institution; bilirubin < 3.0 mg/dLXx_NEWLINE_xXSerum creatinine (adults) OR creatinine clearance \r\n* Adults: =< 1.5 mg/dL; \r\n* Minors: serum creatinine (Cr) =< age-adjusted normal (below) OR\r\n** Age: 12-15; Maximum serum creatinine (mg/dl): 1.2\r\n** Age: > 15; Maximum serum creatinine (mg/dl): 1.5\r\n* >= 40 ml/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine ? 1.5 mg/dL OR creatinine clearance ? 50 mL/min/1.73 m2 for subjects with creatinine >1.5 mg/dLXx_NEWLINE_xXA serum creatinine that is =< 1.5 X upper limit of normal (ULN) based on age/gender as listed in the table below:\r\n* Age 1 to < 2 years, male 0.6 mg/dL, female 0.6 mg/dL\r\n* Age 2 years < 6 years, male 0.8 mg/dL, female 0.8 mg/dL\r\n* Age 6 to < 10 years, male 1.0 mg/dL, female 1.0 mg/dL\r\n* Age 10 to < 13 years, male 1.2 mg/dL, female 1.2 mg/dL\r\n* Age 13 to < 16 years, male 1.5 mg/dL, female 1.4 mg/dL\r\n* Age > 16 years, male 1.7 mg/dL, female 1.4 mg/dLXx_NEWLINE_xXCHEMOTHERAPY/CELL INFUSION ELIGIBILITY: Serum creatinine less than or equal to 1.7 mg/dLXx_NEWLINE_xXSerum creatinine based on age/gender as follows:\r\n* Age 6 months to < 1 year: maximum serum creatinine 0.5 mg/dL for male and 0.5 mg/dL for female\r\n* Age 1 to < 2 years: maximum serum creatinine 0.6 mg/dL for male and 0.6 mg/dL for female\r\n* Age 2 to < 6 years: maximum serum creatinine 0.8 mg/dL for male and 0.8 mg/dL for female\r\n* Age 6 to < 10 years: maximum serum creatinine 1 mg/dL for male and 1 mg/dL for female\r\n* Age 10 to < 13 years: maximum serum creatinine 1.2 mg/dL for male and 1.2 mg/dL for female\r\n* Age 13 to < 16 years: maximum serum creatinine 1.5 mg/dL for male and 1.4 mg/dL for female\r\n* Age >= 16 years: maximum serum creatinine 1.7 mg/dL for male and 1.4 mg/dL for femaleXx_NEWLINE_xXSerum creatinine =< to 1.6 mg/dLXx_NEWLINE_xXCreatinine clearance >= 50 mg/dL within 30 days of registrationXx_NEWLINE_xXCreatinine ? 1.7 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.7 mg/dl within 14 days prior to Step 2 registrationXx_NEWLINE_xXRenal dysfunction defined as a serum creatinine >1.6 mg/dL.Xx_NEWLINE_xXCreatinine < 2.0 mg/dL (a renal consult can override this criteria)Xx_NEWLINE_xXCreatinine > 2.0 mg/dL (a renal consult can override this criteria)Xx_NEWLINE_xXCreatinine =< 2.0 mg/dlXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum bilirubin =< 1.5 mg/dLXx_NEWLINE_xXSerum bilirubin =< 3.0 mg/dL.Xx_NEWLINE_xXSerum creatinine < 140 umol/L (< 1.6 mg/dL) or 1.5 x the upper limit of normal, whichever is lessXx_NEWLINE_xXCreatinine =< 2.0 mg/dL obtained =< 14 days prior to registrationXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) > 60 mL/min/1.73 m^2 by either Cockcroft-Gault formula or analysis normal serum creatinine based on age described below:\r\n* =< 5 years, 0.8 mg/dL\r\n* 5 < age =< 10 years, 1.0 mg/dL\r\n* 10 < age =< 15 years, 1.2 mg/dL\r\n* > 15 years, 1.5 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dlXx_NEWLINE_xXRenal insufficiency, defined as serum creatinine > 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 1.6 mg/dL obtained < 4 weeks prior to starting treatmentXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender within 14 days of registration as follows:\r\n* Age 3 to < 6 years; maximum serum creatinine (mg/dL) 0.8 (male and female)\r\n* Age 6 to < 10 years; maximum serum creatinine (mg/dL) 1 (male and female)\r\n* Age 10 to < 13 years; maximum serum creatinine (mg/dL) 1.2 (male and female)\r\n* Age 13 to < 16 years; maximum serum creatinine (mg/dL) 1.5 (male) and 1.4 (female)\r\n* Age >= 16 years; maximum serum creatinine (mg/dL) 1.7 (male) and 1.4 (female)Xx_NEWLINE_xXAdequate hematological, hepatic, and renal parameters; i.e., hemoglobin > 10 g/dL, creatinine < 3.5 mg/dL, bilirubin < 1.5 mg/dL , and aspartate aminotransferase, alanine aminotransferase < 50 U/L, and alkaline phosphatase < 130 U/L.Xx_NEWLINE_xXSerum creatinine level ?2.5 mg/dL (221 ?mol/L)Xx_NEWLINE_xXCreatinine <2 mg/dLXx_NEWLINE_xXPatients with serum creatinine levels less than 1.5 mg/dLXx_NEWLINE_xXPatients with serum creatine >= 1.5 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dL obtained =< 7 days prior to registrationXx_NEWLINE_xXSerum creatinine < 2 mg/dl, within 28 days prior to registrationXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine < 1.8 mg/dlXx_NEWLINE_xXSerum creatinine less than or equal to 1.4 mg/dLXx_NEWLINE_xXSerum creatinine < 3.0 mg/dLXx_NEWLINE_xXDONOR: Serum creatinine < 1.8 mg/dlXx_NEWLINE_xXObtained =< 14 days prior to registration: Creatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine < 1.7 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 1.7 mg/dlXx_NEWLINE_xXNo end organ damage attributable to a plasma cell disorder, defined as having ANY of the following:\r\n* Hypercalcemia: serum calcium > 1 mg/dL above the upper limit of normal or > 11 mg/dL\r\n* Renal insufficiency: serum creatinine > 2 mg/dL or creatinine clearance < 30 mL per min\r\n* Anemia: hemoglobin value > 2 g/dL below the upper limit of normal or a hemoglobin value < 10 g/dL\r\n* Bone lesions: one or more lytic lesions on skeletal radiography, computed tomography (CT), MRI, PET-CT, or PET-MRIXx_NEWLINE_xXSerum creatinine < 1.5 mg/dlXx_NEWLINE_xXCreatinine =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL (assessed within 14 days prior to registration)Xx_NEWLINE_xXSerum bilirubin =< 2.0 mg/dlXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70mL / min / 1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* 2 to < 6 years: Maximum serum creatinine for both male and female 0.8 mg/dL\r\n* 6 to < 10 years: Maximum serum creatinine for both male and female 1 mg/dL\r\n* 10 to < 13 years: Maximum serum creatinine for both male and female 1.2 mg/dL\r\n* 13 to < 16 years: Maximum serum creatinine for male 1.5 mg/dL and for female 1.4 mg/dL\r\n* >= 16 years: Maximum serum creatinine for male 1.7 mg/dL and for female 1.4 mg/dLXx_NEWLINE_xXSerum creatinine < 1.5 mg/dLXx_NEWLINE_xXCreatinine less than or equal to 2.0 mg/dL (unless considered tumor related)Xx_NEWLINE_xXCreatinine (Cr) =< 1.5 mg/dL x ULNXx_NEWLINE_xXPatients with serum creatinine levels less than 1.5 mg/dLXx_NEWLINE_xXPatients with serum creatinine level greater than 1.5 mg/dLXx_NEWLINE_xXSerum calcium =< 12.0 mg/dLXx_NEWLINE_xXSerum Creatinine =< 3.0 mg/dLXx_NEWLINE_xXSerum creatinine that is at or below 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< to 1.6 mg/dLXx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL, within 14 day prior to registrationXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age: maximum serum creatinine (mg/dL)\r\n* 1 month to < 6 months: 0.4 mg/dL (male and female)\r\n* 6 months to < 1 year: 0.5 mg/dL (male and female)\r\n* 1 to < 2 years: 0.6 mg/dL (male and female)\r\n* 2 to < 6 years: 0.8 mg/dL (male and female)\r\n* 6 to < 10 years: 1 mg/dL (male and female)\r\n* 10 to < 13 years: 1.2 mg/dL (male and female)\r\n* 13 to < 16 years: 1.5 mg/dL (male), 1.4 mg/dL (female)\r\n* >= 16 years: 1.7 mg/dL (male), 1.4 mg/dL (female)Xx_NEWLINE_xXSerum creatinine =< to 1.6 mg/dlXx_NEWLINE_xXSerum creatinine > 1.4 mg/dl =< 30 days prior to study entryXx_NEWLINE_xXCreatinine level of 3 mg/dL or lowerXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* 2 to < 6 years: maximum serum creatinine 0.8 mg/dL (male and female)\r\n* 6 to < 10 years: maximum serum creatinine 1 mg/dL (male and female)\r\n* 10 to < 13 years: maximum serum creatinine 1.2 mg/dL (male and female)\r\n* 13 to < 16 years: maximum serum creatinine 1.5 mg/dL (male), 1.4 mg/dL (female)\r\n* >= 16 years: maximum serum creatinine 1.7 mg/dL (male), 1.4 mg/dL (female)Xx_NEWLINE_xXSerum bilirubin >= 2 mg/dLXx_NEWLINE_xXSerum creatinine >= 2.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL (assessed within 10 days prior to study day 0)Xx_NEWLINE_xXCreatinine =< 2.5 mg/dLXx_NEWLINE_xXSerum creatinine > 2.5 mg/dLXx_NEWLINE_xXEXCLUSION CRITERIA FOR TNBC: Serum creatinine > 2.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dlXx_NEWLINE_xXObtained =< 14 days prior to registration: Creatinine =< 1.0 mg/dLXx_NEWLINE_xXSerum creatinine < 1.5 mg/dLXx_NEWLINE_xXSerum creatinine above 2.0mg/dlXx_NEWLINE_xXCreatinine =< 1.6 mg/dlXx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXSerum creatinine less than or equal to 1.4 mg/dLXx_NEWLINE_xXCreatinine: =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine < 1.6 mg/dlXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine < 1.6 mg/dlXx_NEWLINE_xXBilirubin < 2.0 mg/dl, unless subject has Gilbert’s syndrome (=< 3.0 mg/dL)Xx_NEWLINE_xXSerum creatinine =< to 1.6 mg/dlXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dlXx_NEWLINE_xXCreatinine =< 1.6 mg/dlXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine, creatinine clearance or radioisotope glomerular filtration rate (GFR) > 70 mL/min/1.73m^2 OR a serum creatinine (mg/dL) less than or equal to the following:\r\n* Age (years [yrs]):1-1.99; male (mg/dL): 0.6; female (mg/dL): 0.6\r\n* Age (yrs): 2-5.99; male (mg/dL): 0.8; female (mg/dL): 0.8\r\n* Age (yrs): 6-9.99; male (mg/dL): 1; female (mg/dL): 1\r\n* Age (yrs): 10-12.99; male (mg/dL): 1.2; female (mg/dL): 1.2\r\n* Age (yrs): 13-15.99; male (mg/dL): 1.5; female (mg/dL): 1.4\r\n* Age (yrs): >16; male (mg/dL): 1.7; female (mg/dL): 1.4Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXMagnesium >= 0.9 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) within 7 days prior to enrollment >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age: 1 to < 2 years; maximum serum creatinine (mg/dL): male 0.6; female 0.6\r\n* Age: 2 to < 6 years; maximum serum creatinine (mg/dL): male 0.8; female 0.8\r\n* Age: 6 to < 10 years; maximum serum creatinine (mg/dL): male 1; female 1\r\n* Age: 10 to < 13 years; maximum serum creatinine (mg/dL): male 1.2; female 1.2\r\n* Age: 13 to < 16 years; maximum serum creatinine (mg/dL): male 1.5; female 1.4\r\n* Age: >= 16 years; maximum serum creatinine (mg/dL): male 1.7; female 1.4Xx_NEWLINE_xXCreatinine < 1.5 mg/dl (= 132 umol/L) orXx_NEWLINE_xXCreatinine =< 1.5 mg/dlXx_NEWLINE_xXWithin 6 weeks of day 1: Creatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or 133 umol/LXx_NEWLINE_xXCreatinine < 1.5 mg/dl within 14 days of study entryXx_NEWLINE_xXCreatinine =< 1.5 mg/dlXx_NEWLINE_xXSerum creatinine > 2.2 mg/dl or blood urea nitrogen (BUN) > 40 mg/dl; note: if creatinine is greater than 1.5 x upper limit of normal (ULN), creatinine clearance must be greater than 60ml/minXx_NEWLINE_xXADDITIONAL CRITERIA FOR STUDY CONTINUATION: Serum creatinine =< 2 mg/dlXx_NEWLINE_xXSerum bilirubin =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine =< 3 mg/dLXx_NEWLINE_xXSerum bilirubin < 1.5 mg/dlXx_NEWLINE_xXSerum M component (? 0.5 g/dL), orXx_NEWLINE_xXSerum creatinine ? 2.5 mg/dL;Xx_NEWLINE_xXPatients must have adequate organ function and performance status at the time of the CD8+ memory T-cell infusion, defined by the following:\r\n* Total bilirubin =< 4 mg/dL\r\n* Serum glutamic oxaloacetic transaminase (SGOT) or serum glutamate pyruvate transaminase (SGPT) =< 4 x upper limit of normal (ULN)\r\n* Creatinine =< 3 mg/dL or estimated creatinine clearance >= 40 ml/minXx_NEWLINE_xXCreatinine < 2.5 mg/dlXx_NEWLINE_xXCreatinine < 2 mg/dLXx_NEWLINE_xXSerum creatinine < 2.0 mg/dlXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age 1 to < 2 years: 0.6 mg/dL for males, 0.6 mg/dL for females\r\n* Age 2 to < 6 years: 0.8 mg/dL for males, 0.8 mg/dL for females\r\n* Age 6 to < 10 years: 1.0 mg/dL for males, 1.0 mg/dL for females\r\n* Age 10 to < 13 years: 1.2 mg/dL for males, 1.2 mg/dL for females\r\n* Age 13 to < 16 years: 1.5 mg/dL for males, 1.4 mg/dL for females\r\n* Age >= 16 years: 1.7 mg/dL for males, 1.4 mg/dL for femalesXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) > 70 ml/min/1.73 m^2 OR serum creatinine based on age/gender as follows:\r\n* Age 1 to < 2 years, 0.6 mg/dL (male) and 0.6 mg/dL (female)\r\n* Age > 2 and < 6 years, 0.8 mg/dL(male) and 0.8 mg/dL (female)\r\n* Age > 6 and < 10 years, 1.0 mg/dL (male) and 1.0 mg/dL (female)\r\n* Age > 10 and < 13 years, 1.2 mg/dL (male) and 1.2 mg/dL (female)\r\n* Age > 13 and < 16 years, 1.5 mg/dL (male) and 1.4 mg/dL (female)\r\n* Age > 16 years, 1.7 mg/dL (male) and 1.4 mg/dL (female)Xx_NEWLINE_xXSerum creatinine =< 3.0 mg/dLXx_NEWLINE_xXCreatinine > 1.5 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mgXx_NEWLINE_xXPatients must have an age-adjusted normal serum creatinine (see below) OR a creatinine clearance or glomerular filtration rate (GFR) >= or more than 60 mL/min/1.73 m^2\r\n* Age (years); maximum serum creatinine (mg/dl)\r\n* < 5 years; 0.8 mg/dl\r\n* 5 < age < 10 years; 1.0 mg/dl\r\n* 10 < age < 15 years; 1.2 mg/dl\r\n* > 15 years; 1.5 mg/dlXx_NEWLINE_xXCreatinine < 2.5 mg/dLXx_NEWLINE_xXSerum bilirubin < or =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine < or =< 2.0 mg/dlXx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXCreatinine < 1.8 mg/dLXx_NEWLINE_xXCreatinine < 1.5 mg/dl, obtained within 30 days of study registration orXx_NEWLINE_xXCreatinine =< 1.5 mg/dlXx_NEWLINE_xXSerum creatinine (Cr) > 2 mg/dL, dialysis, or prior renal transplantXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or 13 umol/LXx_NEWLINE_xXSerum creatinine less or equal to 2 mg/dlXx_NEWLINE_xXTo commence second line irinotecan, bilirubin should be < 1 mg/dL; if between 1-2 mg/dL initial dose should be reduced by one dose level; if > 2 mg/dL, then irinotecan will not be usedXx_NEWLINE_xXCreatinine < 1.6 mg/dLXx_NEWLINE_xXResearch participant serum creatinine =< 1.8 mg/dLXx_NEWLINE_xXSerum creatinine =< 2 mg/dlXx_NEWLINE_xXSerum bilirubin > 1.2 mg/dlXx_NEWLINE_xXCreatinine less than or equal to 2.0 mg/dL (unless considered tumor related)Xx_NEWLINE_xXWithin 2 weeks of enrollment: Creatinine =< 1.7 mg/dlXx_NEWLINE_xXCreatinine =< 1.5 mg/dL OR creatinine clearance >= 30 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 mg/dLXx_NEWLINE_xXSerum creatinine > 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or 133 umol/LXx_NEWLINE_xXSerum creatinine within 0.5-1.4 mg/dL, or if serum creatinine outside 0.5-1.4 mg/dL, then renal function (creatinine clearance or glomerular filtration rate [GFR]) > 40 mL/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine > 1.5 mg/dLXx_NEWLINE_xXSerum bilirubin =< 3.0 mg/dLXx_NEWLINE_xXSerum creatinine =< to 1.6 mg/dlXx_NEWLINE_xXPatients must have a serum bilirubin =< 2.0 mg/dlXx_NEWLINE_xXSerum bilirubin must be ? 2.0 mg/dlXx_NEWLINE_xXSerum creatinine =< 3 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dLXx_NEWLINE_xXSerum creatinine ? 2.0 mg/dLXx_NEWLINE_xXSerum bilirubin > 3.0 mg/dL.Xx_NEWLINE_xXSerum creatinine > 2.0 mg/dlXx_NEWLINE_xXSerum creatinine =< to 1.6 mg/dlXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXPatients are required to have a serum creatinine =< 2.0 mg/dL; this value must be obtained within two weeks before protocol entryXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine < 2 mg/dlXx_NEWLINE_xXSerum creatinine =< 2 mg/dlXx_NEWLINE_xXCreatinine =< 1.6 mg/dlXx_NEWLINE_xXCreatinine < 1.6 mg/dLXx_NEWLINE_xXBilirubin < 2.0 mg/dL, unless subject has Gilbert’s Syndrome (=< 3.0 mg/dL)Xx_NEWLINE_xXCreatinine < 2.0 mg/dLXx_NEWLINE_xXRenal disease: serum creatinine > 2.0 mg/dlXx_NEWLINE_xXPatients must have adequate renal function defined as: creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender less than listed value: 1 to < 2 years 0.6 mg/dL for both males and females, 2 to < 6 years 0.8 mg/dL for both males and females, 6 to < 10 years 1 mg/dL for both males and females, 10 to < 13 years 1.2 mg/dL for both males and females, 13 to < 16 years 1.5 mg/dL for males and 1.4 mg/dL for females, >= 16 years 1.7 for males and 1.4 for femalesXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dLXx_NEWLINE_xXRenal impairment with a creatinine > 1.4 mg/dlXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< to 1.6 mg/dlXx_NEWLINE_xXSerum creatinine > 2.0 mg/dlXx_NEWLINE_xXSerum creatinine less than or equal to 1.6 mg/dl (Turnstile II)Xx_NEWLINE_xXSerum creatinine > 2 mg/dLXx_NEWLINE_xXCreatinine < 2.0 mg/dLXx_NEWLINE_xXSerum creatinine < 1.5 mg/dlXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or 133 umol/L obtained =< 2 weeks prior to enrollmentXx_NEWLINE_xXCreatinine (Cr) =< 1.6 mg/dLXx_NEWLINE_xXSerum creatinine < 3 mg/dlXx_NEWLINE_xXRelapsed/refractory MCL: Serum bilirubin < 1.5 mg/dlXx_NEWLINE_xXNewly diagnosed MCL: Serum bilirubin < 1.5 mg/dlXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine > 2.5 mg/dLXx_NEWLINE_xXRECIPIENT: Serum conjugated bilirubin < 2.5 mg/dlXx_NEWLINE_xXSerum creatinine > 2 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine < 1.5 mg%Xx_NEWLINE_xXCreatinine =< 1.7 mg/dlXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 2.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 2 mg/dl or creatinine clearance greater or equal than 40 cc/min; creatinine for pediatric patients =< 2 mg/dl or =< 2 times upper limit of normal for age (whichever is less)Xx_NEWLINE_xXCreatinine < 2.5 mg/dlXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL or 177 umol/LXx_NEWLINE_xXSerum creatinine =< 3 mg/dLXx_NEWLINE_xXSerum creatinine < 1.5 mg/dL or creatinine clearance greater or equal than 60 cc/min as defined by the Cockcroft-Gault Equation: Males(mL/min):(140-age)*IBW(kg) / 72*(serum creatinine (mg/dl)); Females (mL/min):0.85*(140-age)*IBW(kg) / 72*(serum creatinine (mg/dl)).Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL (if > 1.5 mg/dL, then creatinine clearance should be > 60 mL/min)Xx_NEWLINE_xXSerum creatinine less than or equal to 1.6 mg/dl (Turnstile II)Xx_NEWLINE_xXSerum creatinine =< 1.6 mg/dLXx_NEWLINE_xXSerum creatinine < 2.0 mg/dlXx_NEWLINE_xXSerum creatinine < 1.6 mg/dLXx_NEWLINE_xXSerum creatinine (Cr) =< 1.5 mg/dlXx_NEWLINE_xXBilirubin =< 1.5 mg/dL (=< 3.0 mg/dL with liver metastasis)\r\n* Subjects with Gilbert's disease may have bilirubin up to 2.5 mg/dL (or 3.0 mg/dL with liver metastasis)Xx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dlXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL (133 umol/L)Xx_NEWLINE_xXCreatinine < 1.5 mg/dl in males and < 1.4 in femalesXx_NEWLINE_xXCreatinine =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine =< 1.6 mg/dlXx_NEWLINE_xXSerum creatinine based on age/gender; patients that do not meet the criteria but have a 24 hour creatinine clearance or glomerular filtration rate (GFR) (radioisotope or iothalamate) >= 70 ml/min/1.73 m^2 are eligible:\r\n* 2 to < 6 years: 0.8 mg/dL (male and female)\r\n* 6 to < 10 years: 1 mg/dL (male and female)\r\n* 10 to < 13 years: 1.2 mg/dL (male and female)\r\n* 13 to < 16 years: 1.5 mg/dL (male); 1.4 mg/dL (female)\r\n* >= 16 years: 1.7 mg/dL (male); 1.4 mg/dL (female)Xx_NEWLINE_xXCreatinine > 177 ?mol/L (> 2 mg/dL) at screeningXx_NEWLINE_xXHave a serum creatinine level ?1.8 mg/dLXx_NEWLINE_xXCreatinine =< 2 mg/dLXx_NEWLINE_xXEven if organ function abnormalities are considered due to tumor, the upper limit for bilirubin is =< 2.6 mg/dL and creatinine =< 3 mg/dLXx_NEWLINE_xXSerum creatinine > 2.0 mg/dlXx_NEWLINE_xXPatients must have adequate renal function defined as < 1.5 x normal serum creatinine as adjusted for age:\r\n* 0.8 mg/dl for < 5 years of age\r\n* 1.0 mg/dL for > 5 and < 10 years of age\r\n* 1.2 mg/dL for > 10 and < 15 years of age\r\n* 1.5 mg/dL for > 15 years of age\r\n* Or a calculated or measured creatinine clearance or radioisotope glomerular filtration rate (GFR) > 70 ml/min/1.73m^2 obtained within 14 days prior to registrationXx_NEWLINE_xXPatients must have a serum bilirubin =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine =< 2 mg/dlXx_NEWLINE_xXSerum creatinine greater than 1.6 mg/dLXx_NEWLINE_xXSerum creatinine < 1.8 mg/dLXx_NEWLINE_xXPhosphorus >= 2.3 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dl or creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above 2.0 mg/dlXx_NEWLINE_xXSerum creatinine > 2.0 mg/dlXx_NEWLINE_xXCreatinine > 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 2.5 mg/dLXx_NEWLINE_xXCreatine > 2.5 mg/dlXx_NEWLINE_xXCreatinine =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine > 2.0 mg/dl (unless using non iodinated contrast or on dialysis)Xx_NEWLINE_xXSerum creatinine >= 2.0 mg/dl (unless using non iodinated contrast or on dialysis)Xx_NEWLINE_xXSerum bilirubin less than or equal to 2.0 mg/dL unless considered due to involvement by tumor when an upper limit of 5.0 mg/dL is acceptableXx_NEWLINE_xXSerum creatinine less than or equal to 2.0 mg/dL unless considered due to involvement by tumor when an upper limit of 2.5 mg/dL is acceptableXx_NEWLINE_xXCreatinine < 1.5 mg/dl or 125 u/LXx_NEWLINE_xXIn adults: serum creatinine =< 1.5 mg/dl or creatinine clearance > 60 ml/min; and in children serum creatinine (Cr) =< age-adjusted normal\r\n* Age 12-15 years: 1.2 mg/dl\r\n* Age > 15 years: 1.5 mg/dlXx_NEWLINE_xXCreatinine: =< 2.0 mg/dLXx_NEWLINE_xXCreatinine<2mg/dlXx_NEWLINE_xXAdequate renal and hepatic function (creatinine ? 2.0 mg/dl, bilirubin ? 2.0 mg/dl, AST and ALT ? 4X upper limit of normal range).Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXA serum creatinine ? 1.5 mg% obtained ? 2 weeks prior to entryXx_NEWLINE_xXCreatinine < 1.6 mg/dLXx_NEWLINE_xXSerum creatinine must be less than 2.0 mg/dl obtained within 2 weeks prior to study enrollment; if serum creatinine is greater than 1.5 mg/dl, the creatinine clearance calculated from a 24 hour urine collection must be greater than 40 ml/minXx_NEWLINE_xXCreatinine <1.5 mg/dLXx_NEWLINE_xXSerum bilirubin < 1.5 mg/dl performed within 60 days of enrollmentXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 OR a serum creatinine based on age/gender as follows:\r\n* 3 to < 6 years: 0.8 (male and female) maximum serum creatinine (mg/dL)\r\n* 6 to < 10 years: 1 (male and female) maximum serum creatinine (mg/dL)\r\n* 10 to < 13 years: 1.2 (male and female) maximum serum creatinine (mg/dL)\r\n* 13 to < 16 years: 1.5 (male), 1.4 (female) maximum serum creatinine (mg/dL)\r\n* >= 16 years: 1.7 (male), 1.4 (female) maximum serum creatinine (mg/dL)Xx_NEWLINE_xXSerum creatinine ? 2.0 mg/dL (assessed within 14 days prior to study day 0)Xx_NEWLINE_xXCreatinine =< 1.5 mg/dL or 133 umol/LXx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXA serum creatinine based on age/gender as follows:\r\n* Age 1 to < 2 years; 0.6 mg/dL (male) 0.6 mg/dL (female)\r\n* Age 2 to < 6 years; 0.8 mg/dL (male) 0.8 mg/dL (female)\r\n* Age 6 to < 10 years; 1.0 mg/dL (male) 1.0 mg/dL (female)\r\n* Age 10 to < 13 years; 1.2 mg/dL (male) 1.2 mg/dL (female)\r\n* Age 13 to < 16 years; 1.5 mg/dL (male) 1.4 mg/dL (female)\r\n* Age ? 16 years; 1.7 mg/dL (male) 1.4 mg/dL (female)\r\n** The threshold creatinine values in this table were derived from the Schwartz formula for estimating glomerular filtration rate (GFR) (Schwartz et al. J. Peds, 106:522, 1985) utilizing child length and stature data published by the Centers for Disease Control and Prevention (CDC)Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL within 21 days of RT fraction 1.Xx_NEWLINE_xXSerum creatinine =< to 1.6 mg/dlXx_NEWLINE_xXWithin 14 days of study registration: Serum creatinine =< 2 mg/dLXx_NEWLINE_xXSerum creatinine ? 2.0 mg/dL or 177 micromol/L ? 2 weeksXx_NEWLINE_xXDONORS: Serum creatinine < 1.8 mg/dlXx_NEWLINE_xXCreatinine clearance or radioisotope GFR (glomerular filtration rate) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender less than the listed value in the table below: \r\n* 1 to < 2 years 0.6 mg/dL for both males and females, \r\n* 2 to < 6 years 0.8 mg/dL for both males and females, \r\n* 6 to < 10 years 1.0 mg/dL for both males and femalesXx_NEWLINE_xXCreatinine =< 1.9 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine < 1.8 mg/dlXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age 1 to < 2 years: male: 0.6 mg/dL; female: 0.6 mg/dL \r\n* Age 2 to < 6 years: male: 0.8 mg/dL; female: 0.8 mg/dL\r\n* Age 6 to < 10 years: male: 1 mg/dL; female: 1 mg/dL\r\n* Age 10 to < 13 years: male: 1.2 mg/dL; female: 1.2 mg/dL\r\n* Age 13 to < 16 years: male: 1.5 mg/dL; female: 1.4 mg/dL\r\n* Age >= 16 years: male: 1.7 mg/dL; female: 1.4 mg/dLXx_NEWLINE_xXCreatinine < 2 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine < 2 mg/dlXx_NEWLINE_xXSerum creatinine <2 mg/dL, or creatinine clearance ?1.5 × ULN.Xx_NEWLINE_xXWithin 7 days prior to study registration: Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age 1 – 2 years - maximum serum creatinine (mg/dL) 0.6 (male and female)\r\n* Age 2 to < 6 years - maximum serum creatinine (mg/dL) 0.8 (male and female)\r\n* Age 6 to < 10 years - maximum serum creatinine (mg/dL) 1 (male and female)\r\n* Age 10 to < 13 years - maximum serum creatinine (mg/dL) 1.2 (male and female)\r\n* Age 13 to < 16 years - maximum serum creatinine (mg/dL) 1.5 male and 1.4 female\r\n* Age >=16 years - maximum serum creatinine (mg/dL) 1.7 male and 1.4 femaleXx_NEWLINE_xXSerum calcium or albumin-adjusted serum calcium >= 2.1 mmol/L (8.4 mg/dL) and =< 2.9 mmol/L (11.5 mg/dL) (reference range 8.5-10.8 mg/dL)Xx_NEWLINE_xXCreatinine =< 2.0 mg/dL, obtained =< 7 days prior to registrationXx_NEWLINE_xXSerum bilirubin values < 2 mg/dLXx_NEWLINE_xXPerformed within 14 days prior to study: Creatinine =< 2.5 mg/dLXx_NEWLINE_xXA serum creatinine based on age/gender as follows:\r\n* 1 to < 2 years: maximum serum creatinine 0.6 mg/dL (both male and female)\r\n* 2 to < 6 years: maximum serum creatinine 0.8 mg/dL (both male and female)\r\n* 6 to < 10 years: maximum serum creatinine 1 mg/dL (both male and female)\r\n* 10 to < 13 years: maximum serum creatinine 1.2 mg/dL (both male and female)\r\n* 13 to < 16 years: maximum serum creatinine 1.5 mg/dL (male), 1.4 mg/dL (female)\r\n* >= 16 years: maximum serum creatinine 1.7 mg/dL (male), 1.4 mg/dL (female)Xx_NEWLINE_xXCreatinine =< 1.0 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomular filtration rate (GFR) >= 70 mL/min/1.73 m^2 OR serum creatinine based on age/gender as follows:\r\n* 0.8 mg/dL (2 to < 6 years of age) \r\n* 1.0 mg/dL (6 to < 10 years of age)\r\n* 1.2 mg/dL (10 to < 13 years of age) \r\n* 1.5 mg/dL (male) and 1.4 mg/dL (female) (13 to < 16 years of age)\r\n* 1.7 mg/dL (male) and 1.4 mg/dL (female) (>= 16 years of age)Xx_NEWLINE_xXCreatinine < 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age 1 to < 2 years: maximum serum creatinine 0.6 mg/dL (males and females)\r\n* Age 2 to < 6 years: maximum serum creatinine 0.8 mg/dL (males and females)\r\n* Age 6 to < 10 years: maximum serum creatinine 1.0 mg/dL (males and females)\r\n* Age 10 to < 13 years: maximum serum creatinine 1.2 mg/dL (males and females)\r\n* Age 13 to < 16 years: maximum serum creatinine 1.5 mg/dL (males) and 1.4 mg/dL (females)\r\n* Age >= 16 years: maximum serum creatinine 1.7 mg/dL (males) and 1.4 mg/dL (females)Xx_NEWLINE_xXCreatinine =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine < 2.0 mg/dLXx_NEWLINE_xXStep 2: Serum creatinine < 2.0 mg/dLXx_NEWLINE_xXSerum creatinine ? 2.0 mg/dL.Xx_NEWLINE_xXSerum bilirubin greater than 1.5 mg/dlXx_NEWLINE_xXSerum creatinine > 3.0 mg/dlXx_NEWLINE_xXSerum bilirubin > 3.0 mg/dlXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dlXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 OR a serum creatinine based on age/gender as follows:            \r\n* 0.8 mg/dL (2 to < 6 years of age)\r\n* 1.0 mg/dL (6 to < 10 years of age)\r\n* 1.2 mg/dL (10 to < 13 years of age)\r\n* 1.5 mg/dL (male) or 1.4 mg/dL (female) (13 to < 16 years of age)\r\n* 1.7 mg/dL (male) or 1.4 mg/dL (female) (>= 16 years of age)Xx_NEWLINE_xXAge-adjusted serum creatinine =< 1.5 x normal for age or creatinine clearance or glomerular filtration rate (GFR) >= 60 cc/min/1.73 m^2\r\n* Age 1 month to < 6 months: 0.4 mg/dL for males and 0.4 mg/dL for females\r\n* Age 6 months to < 1 year: 0.5 mg/dL for males and 0.5 mg/dL for females\r\n* Age 1 to < 2 years: 0.6 mg/dL for males and 0.6 mg/dL for females\r\n* Age 2 to < 6 years: 0.8 mg/dL for males and 0.8 mg/dL for females\r\n* Age 6 to < 10 years: 1.0 mg/dL for males and 1.0 mg/dL for females\r\n* Age 10 to < 13 years: 1.2 mg/dL for males and 1.2 mg/dL for females\r\n* Age 13 to < 16 years: 1.5 mg/dL for males and 1.4 mg/dL for females\r\n* Age >= 16 years: 1.7 mg/dL for males and 1.4 mg/dL for femalesXx_NEWLINE_xXSerum bilirubin < 1.5 mg/dlXx_NEWLINE_xXPatient has symptomatic MM, as defined by any of the following:\r\n* Lytic lesions or pathologic fractures\r\n* Anemia (hemoglobin < 10 g/dL)\r\n* Hypercalcemia (corrected serum calcium > 11.5 mg/dL)\r\n* Renal insufficiency (creatinine > 1.5 mg/dL)\r\n* Other: symptomatic hyperviscosity, amyloidosisXx_NEWLINE_xXCreatinine =< 2.2 mg/dL.Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dLXx_NEWLINE_xXCreatinine < 1.5 mg/dlXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70mL/min/1.73 m^2 or serum creatinine based on age/gender as follows:\r\n* 1 month to < 6 months: 0.4 mg/dL\r\n* 6 months to < 1 year: 0.5 mg/dL\r\n* 1 to < 2 years: 0.6 mg/dL\r\n* 2 to < 6 years: 0.8 mg/dL\r\n* 6 to < 10 years: 1 mg/dL\r\n* 10 to < 13 years: 1.2 mg/dL\r\n* 13 to < 16 years: 1.5 mg/dL (male), 1.4 mg/dL (female)\r\n* >= 16 years: 1.7 mg/dL (male), 1.4 mg/dL (female)Xx_NEWLINE_xXSerum bilirubin >= 6 mg/dlXx_NEWLINE_xXSerum creatinine > 1.5 mg/dlXx_NEWLINE_xXCreatinine =< 1.3 mg/dlXx_NEWLINE_xXCreatinine clearance OR radioisotope glomerular filtration rate >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* 0.4 mg/dL (1 month to < 6 months of age)\r\n* 0.5 mg/dL (6 months to < 1 year of age)\r\n* 0.6 mg/dL (1 years to < 2 years of age)\r\n* 0.8 mg/dL (2 years to < 6 years of age)\r\n* 1.0 mg/dL (6 years to < 10 years of age)\r\n* 1.2 mg/dL (10 years to < 13 years of age)\r\n* 1.5 mg/dL (male) or 1.4 mg/dL (female) (13 years to < 16 years of age)\r\n* 1.7 mg/dL (male) or 1.4 mg/dL (female) (>= 16 years of age)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age 1 to < 2 years: maximum serum creatinine: 0.6 mg/dL in males and females\r\n* Age 2 to < 6 years: maximum serum creatinine: 0.8 mg/dL in males and females\r\n* Age 6 to < 10 years: maximum serum creatinine: 1 mg/dL in males and females\r\n* Age 10 to < 13 years: maximum serum creatinine: 1.2 mg/dL in males and females\r\n* Age 13 to < 16 years: maximum serum creatinine: 1.5 mg/dL in males and 1.4 mg/dL in females\r\n* Age >= 16 years: maximum serum creatinine: 1.7 mg/dL in males and 1.4 mg/dL in femalesXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2, or a serum creatinine based on age/gender as follows:\r\n* Age < 6 months; maximum serum creatinine (mg/dL): 0.4 for males and females\r\n* Age 6 months to < 1 year; maximum serum creatinine (mg/dL): 0.5 for males and females\r\n* Age 1 to < 2 years; maximum serum creatinine (mg/dL): 0.6 for males and females\r\n* Age 2 to < 6 years; maximum serum creatinine (mg/dL): 0.8 for males and females\r\n* Age 6 to < 10 years; maximum serum creatinine (mg/dL): 1 for males and females\r\n* Age 10 to < 13 years; maximum serum creatinine (mg/dL): 1.2 for males and females\r\n* Age 13 to < 16 years; maximum serum creatinine (mg/dL): 1.5 for males and 1.4 for females\r\n* Age >= 16 years; maximum serum creatinine (mg/dL): 1.7 for males and 1.4 for femalesXx_NEWLINE_xXCreatinine =< 2 mg/dL ORXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXDONOR: Serum creatinine < 1.8 mg/dlXx_NEWLINE_xXSerum bilirubin < 2 mg/dLXx_NEWLINE_xXSerum creatinine less than or equal to 1.3 mg/dLXx_NEWLINE_xXA serum creatinine based on age/gender as follows:\r\n* 6 months to < 1 year: 0.5 mg/dL\r\n* 1 to < 2 years: 0.6 mg/dL\r\n* 2 to < 6 years: 0.8 mg/dL\r\n* 6 to < 10 years: 1 mg/dL\r\n* 10 to < 13 years: 1.2 mg/dL\r\n* 13 to < 16 years: 1.5 mg/dL (male), 1.4 mg/dL (female)\r\n* >= 16 years: 1.7 mg/dL (male), 1.4 mg/dL (female)Xx_NEWLINE_xXCreatinine =< 1.6 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age 1 to < 2 years: maximum serum creatinine (mg/dL): 0.6 for males and 0.6 for females\r\n* Age 2 to < 6 years: maximum serum creatinine (mg/dL): 0.8 for males and 0.8 for females\r\n* Age 6 to < 10 years: maximum serum creatinine (mg/dL): 1 for males and 1 for females\r\n* Age 10 to < 13 years: maximum serum creatinine (mg/dL): 1.2 for males and 1.2 for females\r\n* Age 13 to < 16 years: maximum serum creatinine (mg/dL): 1.5 for males and 1.4 for females\r\n* Age >= 16 years: maximum serum creatinine (mg/dL): 1.7 for males and 1.4 for femalesXx_NEWLINE_xXAge-adjusted normal serum creatinine according to the following table or a creatinine clearance >= 60 ml/min/1.73 m^2:\r\n* Age =< 5 years: maximum serum creatinine 0.8 mg/dL\r\n* Age > 5 =< 10 years: maximum serum creatinine 1.0 mg/dL\r\n* Age > 10 =< 15 years: maximum serum creatinine 1.2 mg/dL\r\n* Age > 15 years: maximum serum creatinine 1.5 mg/dLXx_NEWLINE_xXCreatinine: =< 2.0 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* 1 month to < 6 months: 0.4 mg/dL\r\n* 6 months to < 1 year: 0.5 mg/dL\r\n* 1 to < 2 years: 0.6 mg/dL\r\n* 2 to < 6 years: 0.8 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXPatients must have a serum bilirubin =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine =< to 1.6 mg/dlXx_NEWLINE_xXCreatinine =< 2.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or 133 umol/LXx_NEWLINE_xXSerum creatinine\r\n* Male: =< 1.7 mg/dl\r\n* Female: =< 1.5 mg/dl\r\n* Or estimated creatinine clearance of >= 60 ml/minXx_NEWLINE_xXSerum creatinine =< 1.8 mg/dlXx_NEWLINE_xXSerum creatinine less than or equal to 1.7 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age 1 to < 2 years: 0.6 mg/dL\r\n* Age 2 to < 6 years: 0.8 mg/dL\r\n* Age 6 to < 10 years: 1 mg/dL\r\n* Age 10 to < 13 years: 1.2 mg/dL\r\n* Age 13 to < 16 years: 1.5 mg/dL (males) and 1.4 mg/dL (females)\r\n* Age >= 16 years: 1.7 mg/dL (males) and 1.4 mg/dL (females)Xx_NEWLINE_xXGreater than age-adjusted normal serum creatinine (see below) and a creatinine clearance < 60 mL/min/1.73 m^2\r\n* =< 0.8 mg/dL (age =< 5 years)\r\n* =< 1.0 mg/dL (5 years < age =< 10 years)\r\n* =< 1.2 mg/dL (age > 10 years)Xx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.7 mg/dLXx_NEWLINE_xXSerum creatinine > 2.0 mg/dLXx_NEWLINE_xXSerum creatinine < 1.5 mg/dLXx_NEWLINE_xXAge-adjusted normal serum creatinine according to the following or a creatinine clearance >= 60 ml/min/1.73 m^2\r\n* Age =< 5 years: maximum serum creatinine 0.8 mg/dl\r\n* Age > 5 and =< 10 years: maximum serum creatinine 1.0 mg/dl\r\n* Age > 10 and =< 15 years: maximum serum creatinine 1.2 mg/dl\r\n* Age > 15 years: maximum serum creatinine 1.5 mg/dlXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine less than or equal to 2.5 mg/dlXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min OR a serum creatinine based on age/gender as follows:            \r\n* =< 0.4 mg/dL (for patients aged 1 month to < 6 months)\r\n* =< 0.5 mg/dL (for patients aged 6 months to < 1 year)\r\n* =< 0.6 mg/dL (for patients aged 1 to < 2 years)\r\n* =< 0.8 mg/dL (for patients aged 2 to < 6 years)\r\n* =< 1 mg/dL (for patients aged 6 to < 10 years)\r\n* =< 1.2 mg/dL (for patients aged 10 to < 13 years)\r\n* =< 1.4 mg/dL (for female patients aged >= 13 years)\r\n* =< 1.5 mg/dL (for male patients aged 13 to < 16 years)\r\n* =< 1.7 mg/dL (for male patients aged >= 16 years)Xx_NEWLINE_xXSerum creatinine =< 2 mg/dLXx_NEWLINE_xXSerum creatinine =< 2 mg/dLXx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXSerum bilirubin =< 3.0 mg/dl for Group AXx_NEWLINE_xXSerum bilirubin =< 2.0 mg/dl for Group B or C (unless segmental infusion can be performed, then serum bilirubin =< 3.0 mg/dl allowed)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* 1 to < 2 years: 0.6 mg/dL\r\n* 2 to < 6 years: 0.8 mg/dL\r\n* 6 to < 10 years: 1 mg/dL\r\n* 10 to < 13 years: 1.2 mg/dL\r\n* 13 to < 16 years: 1.5 mg/dL (male), 1.4 mg/dL (female)\r\n* >= 16 years: 1.7 mg/dL (male), 1.4 mg/dL (female)Xx_NEWLINE_xXCreatinine < 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 1.5 mg/dL is recommended; however, institutional norms are acceptableXx_NEWLINE_xXCreatinine =< 2.5 g/dlXx_NEWLINE_xXCreatinine less than or equal to 2.0 mg/dLXx_NEWLINE_xXSerum creatinine 6 months to 1 year: male 0.6 mg/dL (53 µmol/L) female 0.5 mg/dL (44 µmol/L)Xx_NEWLINE_xXSerum creatinine 1 to < 2 years: male 0.6 mg/dL (53 µmol/L) female 0.6 mg/dL (53 µmol/L)Xx_NEWLINE_xXSerum creatinine 2 to < 6 years: male 0.8 mg/dL (71 µmol/L) female 0.8 mg/dL (71 µmol/L)Xx_NEWLINE_xXSerum creatinine 6 to <10 years: male 1 mg/dL (88 µmol/L) female 1 mg/dL (88 µmol/L)Xx_NEWLINE_xXSerum creatinine 10 to <13 years: male 1.2 mg/dL (106 µmol/L) female 1.2 mg/dL (106 µmol/L)Xx_NEWLINE_xXSerum creatinine 13 to <16 years: male 1.5 mg/dL (133 µmol/L) female 1.4 mg/dL (125 µmol/L)Xx_NEWLINE_xXSerum creatinine ?16 years: male 1.7 mg/dL (150 µmol/L) female 1.4 mg/dL (125 µmol/L)Xx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXSubjects must have adequate renal function as evidenced by a serum creatinine of <2.0 mg/dl.Xx_NEWLINE_xXSerum bilirubin =< 1.5 mg/dL; patients with Gilbert's disease: serum bilirubin < 5 mg/dLXx_NEWLINE_xXCreatinine less than or equal to 1.5 mg/dL, or if > 1.5 mg/dL, creatinine clearance must be at least 50 ml/minXx_NEWLINE_xXCreatinine ?1.5mg/dL.Xx_NEWLINE_xXCreatinine =< 1.5 mg/dL OR creatinine clearance >= 30 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 mg/dLXx_NEWLINE_xXSerum creatinine ? 1.5 mg/dlXx_NEWLINE_xXSerum creatinine ? 1.5 mg/dlXx_NEWLINE_xXSerum creatinine ? 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.3 mg/dL if male or =< 1.1 mg/dL if female or and calculated creatinine clearance >= 55 ml/min/1.73 m^2Xx_NEWLINE_xXCreatinine less than 1.4 mg/dlXx_NEWLINE_xXSerum creatinine ? 2.0 mg/dL or 177 µmol/LXx_NEWLINE_xXSerum creatinine > 2.0 mg/dlXx_NEWLINE_xXWithin 14 days prior to registration: Serum creatinine =< 2.0 mg/dLXx_NEWLINE_xXSubject has creatinine > 2 mg/dL (177 ?mol/L).Xx_NEWLINE_xXCreatinine =< 1.5 mg/dL, obtained =< 21 days prior to registrationXx_NEWLINE_xXCreatinine > 2 mg/dL (177 µmol/L) at screening;Xx_NEWLINE_xXSerum creatinine < 2.0 mg/dl within 14 days prior to registrationXx_NEWLINE_xXSerum creatinine < 2.0 mg/dlXx_NEWLINE_xXSerum/plasma creatinine ?1.5 mg/dL.Xx_NEWLINE_xXSerum bilirubin < 2.0 mg/dL unless Gilberts diseaseXx_NEWLINE_xXCreatinine =< 1.5 mg/dlXx_NEWLINE_xXSerum creatinine ? 2.5 mg/dL x ULN.Xx_NEWLINE_xXSerum creatinine ? 2.0 mg/dL.Xx_NEWLINE_xXSerum creatinine level =< 1.5 mg/dLXx_NEWLINE_xXCTCAE version (v)4.0 grade 3-4 electrolyte abnormalities:\r\n* Calcium < 7 mg/dl or > 12.5 mg/dl;\r\n* Glucose < 40 mg/dl or > 250 mg/dl;\r\n* Magnesium < 0.9 mg/dl or > 3 mg/dl;\r\n* Potassium < 3 mmol/L or > 6 mmol/L;\r\n* Sodium < 130 mmol/L or > 155 mmol/LXx_NEWLINE_xXCreatinine =< 2.0 mg/dcLXx_NEWLINE_xXCreatinine up to and including 2 mg/dLXx_NEWLINE_xXCreatinine =< 1.6 mg/dlXx_NEWLINE_xXSerum creatinine =< 2 mg/dLXx_NEWLINE_xXSerum creatinine ? 1.5 g/dLXx_NEWLINE_xXSerum bilirubin =< 2.0 mg/dlXx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXCreatinine (Cr) =< 2 mg/dLXx_NEWLINE_xXCreatinine < 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.7 mg/dlXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine of =< 2 mg/dlXx_NEWLINE_xXCreatinine < 1.6 mg/dlXx_NEWLINE_xXBilirubin < 2.0 mg/dl, unless subject has Gilbert’s syndrome (=< 3.0 mg/dL)Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dlXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXMagnesium 1.6 – 2.6 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL (assessed within 14 days prior to study day 0)Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXPatients must have a serum bilirubin =< 1.5 mg/dlXx_NEWLINE_xXCreatinine =< 3.0 mg/dl, unless considered due to tumorXx_NEWLINE_xXIf the patient is to be treated with cisplatin, the serum creatinine should be =< 1.5 mg%Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 OR serum creatinine based on age/gender as follows:\r\n* 1 month to < 6 months: 0.4 mg/dL\r\n* 6 months to < 1 year: 0.5 mg/dL\r\n* 1 to < 2 years: 0.6 mg/dL\r\n* 2 to < 6 years: 0.8 mg/dL\r\n* 6 to < 10 years: 1 mg/dL\r\n* 10 to < 13 years: 1.2 mg/dL\r\n* 13 to < 16 years: 1.5 mg/dL (male) or 1.4 mg/dL (female)\r\n* >= 16 years: 1.7 mg/dL (male) or 1.4 mg/dL (female)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73m^2 OR a serum creatinine based on age and gender as follows:\r\n* =< 0.8 mg/dL (patients 2 to < 6 years)\r\n* =< 1 mg/dL (patients 6 to < 10 years)\r\n* =< 1.2 mg/dL (patients 10 to < 13 years)\r\n* =<1.4 mg/dL (female patients >= 13 years)\r\n* =< 1.5 mg/dL (male patients 13 to < 16 years)\r\n* =< 1.7 mg/dL (male patients >= 16 years)Xx_NEWLINE_xX(140 - age) x (weight in kg) x (0.85 if female)/ 72 x (serum creatinine in mg/dL)Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine > 2 mg/dL (177 µmol/L), dialysis or prior renal transplant;Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dLXx_NEWLINE_xXCreatinine =< 3 mg/dLXx_NEWLINE_xXCreatinine less than or equal to 2.0 mg/dlXx_NEWLINE_xXCreatinine < 1.5 mg/dLXx_NEWLINE_xXCreatinine < 1.5 mg/dL is recommended; however, institutional norms are acceptableXx_NEWLINE_xXCreatinine =< 1.5mg/dlXx_NEWLINE_xXSerum calcium =< 12.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 2 mg/dlXx_NEWLINE_xXSerum bilirubin < 1.5 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age: 11 to < 13 years old; 1.2 (male, female) maximum serum creatinine (mg/dL)\r\n* Age: 13 to < 16 years old; 1.5 (male), 1.4 (female) maximum serum creatinine (mg/dL)\r\n* Age: >= 16 years old; 1.7 (male), 1.4 (female) maximum serum creatinine (mg/dL)Xx_NEWLINE_xXCreatinine =< 1.8 mg/dlXx_NEWLINE_xXTotal bilirubin =< 1.5 mg/dL or < 2 mg/dL if attributable to hepatic infiltration by neoplastic diseaseXx_NEWLINE_xXCreatinine =< 2 mg/dLXx_NEWLINE_xXSerum bilirubin: ? 1.2 mg/dLXx_NEWLINE_xXSerum creatinine < 2.0 mg/dlXx_NEWLINE_xXSerum bilirubin < 1.5 mg/dlXx_NEWLINE_xXSerum creatinine based on age/gender as noted; patients that do not meet the criteria below but who have a 24-hour creatinine clearance or glomerular filtration rate (GFR) (radioisotope or iothalamate) >= 70 ml/min/1.73 m^2 are eligible\r\n* Serum creatinine for age/gender\r\n** 3 to < 6 years: 0.8 mg/dL\r\n** 6 to < 10 years: 1 mg/dL\r\n** 10 to < 13 years: 1.2 mg/dL\r\n** 13 to < 16 years: 1.5 mg/dL (male) and 1.4 mg/dL (female)\r\n** >= 16 years: 1.7 mg/dL (male) and 1.4 mg/dL (female)Xx_NEWLINE_xXCreatinine =< 1.5 gm/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dlXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXserum creatinine ? 3 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.3 mg/dL; patients with serum creatinine > 1.3 mg/dL may be eligible if creatinine clearance (CrCl) >= 55 mL/min based on the standard Cockcroft and Gault formulaXx_NEWLINE_xXSerum creatinine < 1.4 mg/dlXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 OR a serum creatinine within normal limits based on age/gender as follows:\r\n* Maximum serum creatinine: 3 to < 6 years: 0.8 mg/dL for males and females\r\n* Maximum serum creatinine: 6 to < 10 years: 1 mg/dL for males and females\r\n* Maximum serum creatinine: 10 to < 13 years: 1.2 mg/dL for males and females\r\n* Maximum serum creatinine: 13 to < 16 years: 1.5 mg/dL for males and 1.4 mg/dL for females\r\n* Maximum serum creatinine: >= 16 years: 1.7 mg/dL for males and 1.4 mg/dL for femalesXx_NEWLINE_xXCreatinine =< 1.7 mg/dl within 21 days prior to study registrationXx_NEWLINE_xXSerum bilirubin < 1.5 mg/dlXx_NEWLINE_xXCreatinine =< 1.5 mg/dlXx_NEWLINE_xXCreatinine < 1.5 mg/dLXx_NEWLINE_xXBilirubin =< 1.5 mg/dL (or =< 3.0 mg/dL if due to Gilbert's syndrome)Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dLXx_NEWLINE_xXSerum creatinine that is at or below 2.0 mg/dLXx_NEWLINE_xXSerum phosphate levels >= 2.5 mg/dL or >= 0.8 mmol/LXx_NEWLINE_xXSerum calcium =< 12.0 mg/dLXx_NEWLINE_xXCreatinine =< 1.5 mg/dlXx_NEWLINE_xXAdequate renal function defined as: creatinine clearance or radioisotope glomerular filtration rate (GFR) 70 mL/min/1.73 m^2 OR a serum creatinine based on age and gender as follows:\r\n* Maximum serum creatinine (mg/dL)\r\n** 1 month to < 6 months of age - 0.4 mg/dL (male), 0.4 mg/dL (female)\r\n** 6 months to < 1 year of age - 0.5 mg/dL (male), 0.5 mg/dL (female)\r\n** 1 to < 2 years of age - 0.6 mg/dL (male), 0.6 mg/dL (female)\r\n** 2 to < 6 years of age - 0.8 mg/dL (male), 0.8 mg/dL (female)\r\n** 6 to < 10 years of age - 1.0 mg/dL (male), 1.0 mg/dL (female)\r\n** 10 to < 13 years of age - 1.2 mg/dL (male), 1.2 mg/dL (female)\r\n** 13 to < 16 years of age - 1.5 mg/dL (male), 1.4 mg/dL (female)\r\n** >= 16 years of age - 1.7 mg/dL (male), 1.4 mg/dL (female)\r\n*** The threshold creatinine values in this table were derived from the Schwartz formula for estimating GFR utilizing child length and stature data published by the Centers for Disease Control and Prevention (CDC)Xx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine < 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender less than listed value in the table below: 1 to < 2 years 0.6 mg/dL for both males and females, 2 to < 6 years 0.8 mg/dL for both males and females, 6 to < 10 years 1 mg/dL for both males and females, 10 to < 13 years 1.2 mg/dL for both males and females, 13 to < 16 years 1.5 mg/dL for males and 1.4 mg/dL for females, >= 16 years 1.7 for males and 1.4 for femalesXx_NEWLINE_xXSerum calcium =< 12.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.5 mg/dLXx_NEWLINE_xXCreatinine > 177 umol/L (2 mg/dL)Xx_NEWLINE_xXLack of acute renal failure/requirement for dialysis, as evidenced by creatinine < 1.6 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXcreatinine < 2 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine < 2.0 mg/dLXx_NEWLINE_xXSerum creatinine >= 2.0 mg/dLXx_NEWLINE_xXAdequate renal function defined as creatinine within normal range for age or calculated glomerular filtration rate (GFR) > 100 ml/min/1.73 m^2\r\n* 1 to < 2 years; maximum serum creatinine (mg/dL) male 0.6, female 0.6\r\n* 2 to < 6 years; maximum serum creatinine (mg/dL) male 0.8, female 0.8\r\n* 6 to < 10 years; maximum serum creatinine (mg/dL) male 1, female 1\r\n* 10 to < 13 years; maximum serum creatinine (mg/dL) male 1.2, female 1.2\r\n* 13 to < 16 years; maximum serum creatinine (mg/dL) male 1.5, female 1.4\r\n* >= 16 years; maximum serum creatinine (mg/dL) male 1.7, female 1.4Xx_NEWLINE_xXParticipants must have an age-adjusted normal serum creatinine or a creatinine clearance of at least 50 ml/min/1.73 m^2\r\n* Age 3 to 5 years: .42 mg/dL\r\n* Age 5 to < 10 years: 1 mg/dL\r\n* Age 10 to < 13 years: 1.2 mg/dL\r\n* Age 13 to < 16 years: 1.5 mg/dL (male), 1.4 mg/dL (female)\r\n* Age 16 and older: 1.7 mg/dL (male), 1.4 md/dL (female)Xx_NEWLINE_xXCreatinine ? 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 x the upper limit of normal for age, or calculated creatinine clearance or nuclear glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2\r\n* =< 0.6 mg/dL (1 to < 2 years of age)\r\n* =< 0.8 mg/dL (2 to < 6 years of age)\r\n* =< 1.0 mg/dL (6 to < 10 years of age)\r\n* =< 1.2 mg/dL (10 to < 13 years of age)\r\n* =< 1.4 mg/dL (females >= 13 years of age)\r\n* =< 1.5 mg/dL (males 13 to < 16 years of age)\r\n* =< 1.7 mg/dL (males >= 16 years of age)Xx_NEWLINE_xXSerum creatinine less than or equal to 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL (133 umol/L) or, if > 1.5 mg/dL: calculated creatinine clearance (ClCR) >= 50 mL/min (tested within 14 days prior to registration)Xx_NEWLINE_xXCreatinine =< 1.5 mg/dlXx_NEWLINE_xXSerum creatinine ?2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.5 mg/dLXx_NEWLINE_xXSerum creatinine based on age, or creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 50 ml/min/1.73m^2 (GFR >= 40 ml/min/1.73m^2 if < 2 years of age)\r\n* Maximum serum creatinine based on age\r\n** 0.8 mg/dL (=< 5 years of age)\r\n** 1.0 mg/dL (5 to =< 10 years of age)\r\n** 1.2 mg/dL (10 to =< 15 years of age)\r\n** 1.5 mg/dL (> 15 years of age)Xx_NEWLINE_xXCreatinine =< 1.8 mg/dlXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or 133 umol/LXx_NEWLINE_xXCreatinine =< 1.5 mg/dL (133 umol/L), or if > 1.5 mg/dL, calculated creatinine clearance >= 50 cc/min)Xx_NEWLINE_xXGlomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or serum creatinine adjusted for age and gender as follows: \r\n* Age 1 to < 2 years: maximum serum creatinine 0.6 mg/dL for males and 0.6 mg/dL for females\r\n* Age 2 to < 6 years: maximum serum creatinine 0.8 mg/dL for males and 0.8 mg/dL for females\r\n* Age 6 to < 10 years: maximum serum creatinine 1 mg/dL for males and 1 mg/dL for females\r\n* Age 10 to < 13 years: maximum serum creatinine 1.2 mg/dL for males and 1.2 mg/dL for females\r\n* Age 13 to < 16 years: maximum serum creatinine 1.5 mg/dL for males and 1.4 mg/dL for females\r\n* Age >= 16 years: maximum serum creatinine 1.7 mg/dL for males and 1.4 mg/dL for femalesXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine > 1.5 mg/dlXx_NEWLINE_xXCreatinine =< 1.7 mg/dlXx_NEWLINE_xXSerum creatinine < 1.4 mg/dl in females and < 1.5 mg/dl in males, and creatinine clearance > 60 mL/minXx_NEWLINE_xXSerum creatinine =< 2 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL or 177 umol/LXx_NEWLINE_xXCreatinine >= 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL or 177 umol/LXx_NEWLINE_xXSerum creatinine less than 1.1 mg/dl for females and less than 1.4 mg/dl for malesXx_NEWLINE_xXSerum bilirubin level of less than 1.5 mg/dlXx_NEWLINE_xXSerum creatinine < 2 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dlXx_NEWLINE_xXPlasma phosphate >= 2.3 and < 4.8 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.4 mg/dLXx_NEWLINE_xXSerum creatinine < 1.4 mg/dL (per manufacturer, metformin is contraindicated in the presence of renal dysfunction defined as a serum creatinine > 1.4 mg/dL in females and in patients with abnormal clearance)Xx_NEWLINE_xXA serum creatinine based on age/gender as follows:\r\n* =< 0.6 mg/dL (for 1 to < 2 years of age)\r\n* =< 0.8 mg/dL (for 2 to < 6 years of age)\r\n* =< 1.0 mg/dL (for 6 to < 10 years of age)\r\n* =< 1.2 mg/dL (for 10 to < 13 years of age)\r\n* =< 1.4 mg/dL (for females >= 13 years of age)\r\n* =< 1.5 mg/dL (for males 13 to < 16 years of age)\r\n* =< 1.7 mg/dL (for males >= 16 years of age)Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine >= 2.0 mg/dLXx_NEWLINE_xXPatients must have a creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 60ml/min/1.73 m^2 or a normal serum creatinine based on age/gender:\r\nAge: 6 to < 10 years; maximum serum creatinine (mg/dL): 1\r\nAge: 10 to < 13 years; maximum serum creatinine (mg/dL): 1.2\r\nAge: 13 to < 16 years; maximum serum creatinine (mg/dL): 1.5 (male) 1.4 (female)\r\nAge: >= 16 years; maximum serum creatinine (mg/dL): 1.7 (male) 1.4 (female)Xx_NEWLINE_xXCreatinine =< 2.0 mgXx_NEWLINE_xXCreatinine < 1.6 mg/dlXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 3.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.8 mg/dLXx_NEWLINE_xXSerum bilirubin < 1.5 mg/dlXx_NEWLINE_xXSerum creatinine =< 2.5 mg/dLXx_NEWLINE_xXCreatinine < 2.5 mg/dLXx_NEWLINE_xXCreatinine =< 1.5 mg/dL OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXSerum creatinine < 2.0 mg/dLXx_NEWLINE_xXCreatinine > 177 umol/L (2 mg/dL)Xx_NEWLINE_xXSerum creatinine level > 1.5 X institution’s ULN (University of California San Diego [UCSD] lab ULN = males 1.7 mg/dl; females 0.95 mg/dl)Xx_NEWLINE_xXSerum calcium =< 12.0 mg/dLXx_NEWLINE_xXNormal serum creatinine based on age as shown below or glomerular filtration (GFR) > 70 ml/min/1.73m^2:\r\n* Age =< 5 years, maximum serum concentration 0.8 mg/dL\r\n* 5 < age < 10, maximum serum concentration 1.0 mg/dL\r\n* 10 < age < 15, maximum serum concentration 1.2 mg/dL\r\n* Age > 15, maximum serum concentration 1.5 mg/dLXx_NEWLINE_xXDONOR: Serum creatinine < 1.8 mg/dlXx_NEWLINE_xXSerum calcium =< 12.0 mg/dLXx_NEWLINE_xXCreatinine =< 1.8 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL (133 umol/L); or, if serum creatinine > 1.5 mg/dL: calculated creatinine clearance (ClCR) >= 50 mL/minXx_NEWLINE_xXWithin one week of study entry: Serum creatinine =< 1.5 mg/dlXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dlXx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXcreatinine ? 2.0 mg/dL ORXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine < 2.0 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/m^2 OR a serum creatinine based on age/gender as follows:\r\n* 0.4 mg/dL (1 month to < 6 months of age)\r\n* 0.5 mg/dL (6 months to < 1 year of age)\r\n* 0.6 mg/dL (1 to < 2 years of age)\r\n* 0.8 mg/dL (2 to < 6 years of age)\r\n* 1.0 mg/dL (6 to 10 years of age)\r\n* 1.2 mg/dL (10 to < 13 years of age)\r\n* 1.5 mg/dL (male) or 1.4 mg/dL (female) (13 to < 16 years of age)\r\n* 1.7 mg/dL (male) or 1.4 mg/dL (female) (>= 16 years of age)Xx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine (Cr) =< 2.0 mg/dlXx_NEWLINE_xXSerum Creatinine < 1.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.6 mg/dLXx_NEWLINE_xXCreatinine < 2.5 mg/dlXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine =< to 1.6 mg/dlXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL (133 umol/L), OR if > 1.5 mg/dL: calculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXSerum creatinine > 1.5 mg/dLXx_NEWLINE_xXRenal insufficiency creatinine > 2.5 mg/dlXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL (133 umol/L) OR, if > 2.0 mg/dL: calculated creatinine clearance (ClCR) >= 50 mL/minXx_NEWLINE_xXCreatinine < 1.5 mg/dLXx_NEWLINE_xXSerum creatinine < 2.0 mg/dlXx_NEWLINE_xXSerum creatinine > 1.4 mg/dl =< 28 days prior to study entryXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dl orXx_NEWLINE_xXNormal serum creatinine for age (below) or creatinine clearance > 60 ml/min/1.73 m^2\r\n* 18 months (mon) < 2 years 0.6 mg/dL\r\n* 2 to < 6 years: maximum serum creatinine 0.8 mg/dL\r\n* 6 to < 10 years: maximum serum creatinine 1.0 mg/dL\r\n* 10 to < 13 years: maximum serum creatinine 1.2 mg/dL\r\n* 13 to < 16 years: maximum serum creatinine 1.5 mg/dL (male), 1.4 mg/dL (female)\r\n* >= 16 years: maximum serum creatinine 1.7 mg/dL (male), 1.4 mg/dL (female)Xx_NEWLINE_xXSerum calcium =< 12.0 mg/dLXx_NEWLINE_xXCreatinine =< 2 mg/dLXx_NEWLINE_xXSerum bilirubin =< 1.5 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine less than or equal to 3.0 mg/dL (unless considered tumor related)Xx_NEWLINE_xXSerum bilirubin =< 2.0 mg/dl, within 4 weeks prior to first immunizationXx_NEWLINE_xXSerum creatinine > 1.6 mg/dlXx_NEWLINE_xXSerum creatinine less than or equal to 2.0 mg/dLXx_NEWLINE_xXCreatinine < 3 mg/dlXx_NEWLINE_xXSerum creatinine =< 2 mg/dLXx_NEWLINE_xXCreatinine < 2 mg/dLXx_NEWLINE_xXNormal creatinine for age:\r\n* 0.8 mg/dL for less than or equal to 5 years\r\n* 1 mg/dL for 6 to less than or equal to 10 years\r\n* 1.2 mg/dL for 11 to less than or equal to 15 years\r\n* 1.5 mg/dL for greater than or equal to 16 years ORXx_NEWLINE_xXSubject has renal insufficiency as defined by a serum creatinine > 2.2 mg/dl or blood urea nitrogen (BUN) > 40 mg/dl (Note: If creatinine is greater than 1.5 x upper limit of normal (ULN), creatinine clearance must be greater than 60ml/min)Xx_NEWLINE_xXSerum creatinine =< 2 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dLXx_NEWLINE_xX(continued from no. 17) The lab will measure protein concentration (mg/dL) and creatinine concentration (mg/dL). The UPCR is derived as follows: protein concentration (mg/dL)/creatinine (mg/dL).Xx_NEWLINE_xXCreatinine =< 2.0 mg/dlXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 2 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXPRIOR TO POST-TRANSPLANT IMMUNOTHERAPY: Creatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine within normal limits based on age as follows:\r\n* Age (years): maximum serum creatinine (mg/dL)\r\n** =< 5: 0.8 mg/dL\r\n** 5 < age =< 10: 1.0 mg/dL\r\n** 10 < age =< 15: 1.2 mg/dL\r\n** > 15: 1.5 mg/dL\r\nOR creatinine clearance >= 60 mL/min for adults or >= 60 mL/min/1.73m^2 for children with creatinine levels above institutional upper limit of normalXx_NEWLINE_xXSerum creatinine less than or equal to 1.6 mg/dlXx_NEWLINE_xXSerum bilirubin =< 2.0 mg/dlXx_NEWLINE_xXSerum Creatinine ? 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine > 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dl; if serum creatinine is 1.2-1.5 mg/dl, the creatinine clearance (either measured or calculated) must be 50 ml/min or greaterXx_NEWLINE_xXCreatinine < 1.6 mg/dL (myeloablative regimen 4, reduced intensity regimen 3) or < 3.0 mg/dL (nonmyeloablative regimen 2)Xx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXAn age-adjusted normal serum creatinine (see below) OR a creatinine clearance >= 70 mL/min/1.73 m^2 \r\n* Serum creatinine =< 0.8 mg/dl (age =< 5 years)\r\n* Serum creatinine =< 1.0 mg/dl (age > 5 and =< 10 years)\r\n* Serum creatinine =< 1.2 mg/dl (age > 10 and =< 15 years)\r\n* Serum creatinine =< 1.5 mg/dl (age > 15 years)Xx_NEWLINE_xXAdequate liver function (bilirubin less than or equal to 3.0 mg/dl, unless considered due to tumor), and renal function (creatinine less than or equal to 3.0 mg/dl, unless considered due to tumor)Xx_NEWLINE_xXPatients must have a calculated creatinine clearance or radioisotope glomerular filtration rate (GFR) 70ml/min/1.73 m^2 OR a normal serum creatinine based on age/gender in the chart below: \r\n* Age: 1 month to < 6 months; maximum serum creatinine: male 0.4 mg/dL; female 0.4 mg/dL\r\n* Age: 6 months to < 1 year; maximum serum creatinine: male 0.5 mg/dL; female 0.5 mg/dL\r\n* Age: 1 to < 2 years; maximum serum creatinine: male 0.6 mg/dL; female 0.6 mg/dL\r\n* Age: 2 to < 6 years; maximum serum creatinine: male 0.8 mg/dL; female 0.8 mg/dL\r\n* Age: 6 to < 10 years; maximum serum creatinine: male 1 mg/dL; female 1 mg/dL\r\n* Age: 10 to < 13 years; maximum serum creatinine: male 1.2 mg/dL; female 1.2 mg/dL\r\n* Age: 13 to < 16 years; maximum serum creatinine: male 1.5 mg/dL; female 1.4 mg/dL\r\n* Age: >= 16 years; maximum serum creatinine: male 1.7 mg/dL; female 1.4 mg/dLXx_NEWLINE_xXRenal dysfunction defined as creatinine ? 2.0 mg/dL.Xx_NEWLINE_xXSerum creatinine < 2.0 mg/dL or 177 ?mol/LXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine < 2 mg/dlXx_NEWLINE_xXGlomerular filtration rate >= 60 cc/min/1.73 m^2 or serum creatinine based on age as follows:\r\n* 1 to 2 years: 0.6 mg/dL for males and females\r\n* 2 to 6 years: 0.8 mg/dL for males and females\r\n* 6 to 10 years: 1 mg/dL for males and females\r\n* 10 to < 13 years: 1.2 mg/dL for males and females\r\n* 13 to 16 years: 1.5 mg/dL for males and 1.4 mg/dL for females\r\n* > 16 years: 1.7 mg/dL for males and 1.4 mg/dL for femalesXx_NEWLINE_xXRenal insufficiency (serum creatinine > 2 mg/dL).Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dlXx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXPatients must have a serum creatinine =< 2.0 mg/dL within 72 hours of initiating the induction cycleXx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.8 mg/dlXx_NEWLINE_xXCreatinine > 177 ?mol/L (> 2 mg/dL) at screening.Xx_NEWLINE_xXSerum creatinine > 1.7 mg/dLXx_NEWLINE_xXCreatinine should be < 3 mg/dL due to diseaseXx_NEWLINE_xXCreatinine > 2.0 mg/dlXx_NEWLINE_xXSerum creatinine levels =< 1.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or 133 umol/LXx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< to 1.6 mg/dlXx_NEWLINE_xXCreatinine =< 2.0 X mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dlXx_NEWLINE_xXSerum creatinine < 2.0 mg/dlXx_NEWLINE_xXCreatinine =< 2.0 mg/dL; patients on renal replacement therapy are not eligibleXx_NEWLINE_xXSerum creatinine > 2 mg/dlXx_NEWLINE_xXSerum creatinine =< to 1.6 mg/dlXx_NEWLINE_xXSerum bilirubin < 1.5 mg/dlXx_NEWLINE_xXSerum creatinine=< 2.0 mg/dLXx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXCreatinine ? 2.0 mg/dLXx_NEWLINE_xXAge-adjusted normal serum creatinine according to the following table or a creatinine clearance >= 60 ml/min/1.73 m^2:\r\n* =< 5 years: 0.8 mg/dl\r\n* > 5 years =< 10 years: 1.0 mg/dl\r\n* > 10 years =< 15 years: 1.2 mg/dl\r\n* > 15 years: 1.5 mg/dlXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dl or calculated clearance >= 50 mL/min/1.73 m^2 for patients with serum creatinine levels > 1.5 mg/dlXx_NEWLINE_xXSerum creatinine =< 3 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dl or calculated clearance >= 50 mL/min/1.73 m^2 for patients with serum creatinine levels > 1.5 mg/dlXx_NEWLINE_xXSerum creatinine less than or equal to 3 mg/dL within 24 hours of enrollmentXx_NEWLINE_xXNo impairment of renal function (serum creatinine less than 1.1 mg/dl for females and less than 1.4 mg/dl for males)Xx_NEWLINE_xXNo impairment of hepatic function (serum bilirubin level of less than 1.2 mg/dl)Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine less than or equal to 1.6 mg/dlXx_NEWLINE_xXDONOR: Serum creatinine < 1.8 mg/dLXx_NEWLINE_xXRenal insufficiency (creatinine >= 2.0 mg/dl)Xx_NEWLINE_xXRECURRENT/ PROGRESSIVE DIPG (STRATUM 1): Serum creatinine based on age/gender as noted below; patients that do not meet the criteria below but have a 24-hour creatinine clearance or glomerular filtration rate (GFR) (radioisotope or iothalamate) >= 70 ml/min/1.73 m^2 are eligible\r\n* 2 to < 6 years: 0.8 mg/dL\r\n* 6 to < 10 years: 1 mg/dL\r\n* 10 to < 13 years: 1.2 mg/dL\r\n* 13 to < 16 years: 1.5 mg/dL (male), 1.4 mg/dL (female)\r\n* >= 16 years: 1.7 mg/dL (male), 1.4 mg/dL (female)Xx_NEWLINE_xXNON-PROGRESSED DIPG (STRATUM 2): Serum creatinine based on age/gender as noted below; patients that do not meet the criteria below but have a 24-hour creatinine clearance or glomerular filtration rate (GFR) (radioisotope or iothalamate) >= 70 ml/min/1.73 m^2 are eligible\r\n* 2 to < 6 years: 0.8 mg/dL\r\n* 6 to < 10 years: 1 mg/dL\r\n* 10 to < 13 years: 1.2 mg/dL\r\n* 13 to < 16 years: 1.5 mg/dL (male), 1.4 mg/dL (female)\r\n* >= 16 years: 1.7 mg/dL (male), 1.4 mg/dL (female)Xx_NEWLINE_xXCreatine: =< 2 mg/dLXx_NEWLINE_xXPatients must have an adequate renal function as documented by serum creatinine less than or equal to 2.0 mg/dL.Xx_NEWLINE_xXSerum creatinine greater than 2.0 mg/dlXx_NEWLINE_xXSerum creatinine < 1.6 mg/dL. Serum bilirubin < 2X upper limit of normal.Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age 1 to < 2 years (male and female: 0.6 mg/dL)\r\n* Age 2 to < 6 years (male and female: 0.8 mg/dL)\r\n* Age 6 to < 10 years (male and female: 1 mg/dL)\r\n* Age 10 to < 13 years (male and female: 1.2 mg/dL)\r\n* Age 13 to < 16 years (male: 1.5 mg/dL and female: 1.4 mg/dL)\r\n* Age >= 16 (male: 1.7 mg/dL and female: 1.4 mg/dL)Xx_NEWLINE_xXRenal dysfunction defined as serum creatinine ? 2.0 mg/dl.Xx_NEWLINE_xXPatients with plasma creatinine level greater than 1.3 mg/dLXx_NEWLINE_xXRenal dysfunction: Creatinine levels >2 mg/dL or chronic dialysis.Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70mL/min/1.73 m^2or a serum creatinine based on age/gender as follows:\r\n* 1 to < 2 years: 0.6 mg/dL\r\n* 2 to < 6 years: 0.8 mg/dL\r\n* 6 to < 10 years: 1 mg/dL\r\n* 10 to < 13 years: 1.2 mg/dL\r\n* 13 to <16 years: 1.5 mg/dL (males), 1.4 mg/dL (females)\r\n* >= 16 years: 1.7 mg/dL (males), 1.4 mg/dL (females)Xx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine < 1.6 mg/dLXx_NEWLINE_xXSerum creatinine =< 3 mg/dLXx_NEWLINE_xXSerum calcium =< 12.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.9 mg/dLXx_NEWLINE_xXSerum creatinine =< 2 mg/dL (or, if creatinine > 2 mg/dL, then a creatinine clearance of at least 35 ml/min (measured or estimated by the Cockcroft formulaXx_NEWLINE_xXSerum creatinine ? 1.5 g/dLXx_NEWLINE_xXSerum creatinine =< to 1.6 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL or creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above 2.0 mg/dLXx_NEWLINE_xXSerum creatinine equal to or less than 2.0 mg/dLXx_NEWLINE_xXSerum Creatinine ? 2.0mg/dLXx_NEWLINE_xXA serum creatinine based on age/gender as follows: (threshold creatinine values were derived from the Schwartz formula for estimating GFR)\r\n* Age (12 to < 13 years) - serum creatinine of 1.2 mg/dL\r\n* Age (13 to < 16 years) - serum creatinine of 1.5 mg/dL (male) and 1.4 mg/dL (female)\r\n* Age (>= 16 years) - serum creatinine of 1.7 mg/dL (male) and 1.4 mg/dL (female)Xx_NEWLINE_xXPatients must have adequate renal function, defined as:\r\n* Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or\r\n* A serum creatinine based on age/gender as follows:\r\n** 1 month to < 6 months: 0.4 mg/dL\r\n** 6 months to < 1 year: 0.5 mg/dL\r\n** 1 to < 2 years: 0.6 mg/dL\r\n** 2 to < 6 years: 0.8 mg/dL\r\n** 6 to < 10 years: 1 mg/dL\r\n** 10 to < 13 years: 1.2 mg/dL\r\n** 13 to < 16 years: 1.5 mg/dL (male); 1.4 mg/dL (female) \r\n** >= 16 years: 1.7 mg/dL (male); 1.4 mg/dL (female)Xx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXSerum creatinine ? 1.5 g/dLXx_NEWLINE_xXTotal bilirubin of ? 1.5 mg/dL or ? 2.0 mg/dL for subjects with liver metastasisXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dlXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine ? 1.5 mg/dlXx_NEWLINE_xXCreatinine < 2.5 mg/dlXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine =< 3 mg/dLXx_NEWLINE_xXCreatinine < 1.5 gm/dLXx_NEWLINE_xXSerum creatinine =< 2.5 mg/dLXx_NEWLINE_xXCreatinine (Cr) > 2 mg/dLXx_NEWLINE_xXCreatinine =< 3 mg/dLXx_NEWLINE_xXSerum creatinine ?1.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 2 mg/dLXx_NEWLINE_xXNormal creatinine for age:\r\n* =< 0.8 mg/dL (age =< 5 years)\r\n* =< 1 mg/dL (age 6 to =< 10 years)\r\n* =< 1.2 mg/dL (age 11 to =< 15 years)\r\n* =< 1.5 mg/dL (age >= 16 years)\r\nORXx_NEWLINE_xXCreatinine =< 1.8 mg/dlXx_NEWLINE_xXSerum bilirubin =< 1.5 mg/dL; except for patients with Gilbert's disease: serum bilirubin < 5 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 60 ml/min/1.73 m^2 or a normal serum creatinine based on age described in the table below:\r\n* Age: =< 5 years; maximum serum creatinine: 0.8 mg/dL\r\n* Age: 5 < age =< 10 years; maximum serum creatinine: 1.0 mg/dL\r\n* Age: 10 < age =< 15 years; maximum serum creatinine: 1.2 mg/dL\r\n* Age: > 15 years; maximum serum creatinine: 1.5 mg/dLXx_NEWLINE_xXCreatinine < 1.5 mg/dLXx_NEWLINE_xXCreatinine < 1.7 mg/dLXx_NEWLINE_xXSerum creatinine =< to 1.6 mg/dlXx_NEWLINE_xXSerum creatinine < 1.4 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* 0.6 mg/dL (1 to < 2 years of age)\r\n* 0.8 mg/dL (2 to < 6 years of age)\r\n* 1.0 mg/dL (6 to < 10 years of age)\r\n* 1.2 mg/dL (10 to < 13 years of age)\r\n* 1.5 mg/dL (male) or 1.4 mg/dL (female) (13 to < 16 years of age)\r\n* 1.7 mg/dL (male) or 1.4 mg/dL (female) (>= 16 years of age)Xx_NEWLINE_xXCreatinine =< 2.0 mg/dLXx_NEWLINE_xXSerum creatinine < 1.5 mg/dlXx_NEWLINE_xXSerum creatinine =/< 2.0mg/dLXx_NEWLINE_xXCreatinine =< ULN for institution mg/dLXx_NEWLINE_xXCreatinine =< 2.0 mg/dlXx_NEWLINE_xXSerum M ?500 mg/dLXx_NEWLINE_xXSerum M ?500 mg/dLXx_NEWLINE_xXSerum M ?500 mg/dLXx_NEWLINE_xXA history of renal dysfunction (serum creatinine > 1.8 mg/dL)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 OR serum creatinine based on age and/or gender as follows:\r\n* =< 0.6 mg/dL (1 to < 2 years of age)\r\n* =< 0.8 mg/dL (2 to < 6 years of age)\r\n* =< 1.0 mg/dL (6 to < 10 years of age)\r\n* =< 1.2 mg/dL (10 to < 13 years of age)\r\n* =< 1.5 mg/dL (male) or 1.4 mg/dL (female) (13 to < 16 years of age)\r\n* =< 1.7 mg/dL (male) or 1.4 mg/dL (female) ( >= 16 years of age)Xx_NEWLINE_xXSerum creatinine > 1.5 mg/dlXx_NEWLINE_xXSerum bilirubin levels =< 1.5 mg/dLXx_NEWLINE_xXSerum creatinine levels =< 1.5 mg/dLXx_NEWLINE_xXAdequate renal sufficiency (serum creatinine <1.5 mg/dL).Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73m^2 or serum creatinine based on age as follows:\r\n*Age (Years) - Maximum Serum Creatinine (mg/dL)\r\n** =< 5 years old - 0.8 mg/dL\r\n** =< 5 age < 10 years old - 1.0 mg/dL\r\n** 10 = < age < 15 years old - 1.2 mg/dL\r\n** >= 15 years old - 1.5 mg/dLXx_NEWLINE_xXSerum creatinine < 1.5 mg/dLXx_NEWLINE_xXSerum creatinine levels =< 1.5 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73m^2 OR serum creatinine based on age as follows:\r\n*Age (years) =< 5 - maximum serum creatinine 0.8 mg/dL\r\n* 5 < age =< 10 - maximum serum creatinine 1.0 mg/dL\r\n* 10 < age =< 15 - maximum serum creatinine 1.2 mg/dL\r\n* Age > 15 - maximum serum creatinine 1.5 mg/dLXx_NEWLINE_xXSerum bilirubin < 2.0 mg/dLXx_NEWLINE_xXSerum creatinine < 2.0 mg/dLXx_NEWLINE_xXSerum bilirubin < 3 mg/dlXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:                        \r\n* No greater than 0.4 mg/dL (1 month to < 6 months)\r\n* No greater than 0.5 mg/dL (6 months to < 1 year)\r\n* No greater than 0.6 mg/dL (1 to < 2 years)\r\n* No greater than 0.8 mg/dL (2 to < 6 years)\r\n* No greater than 1.0 mg/dL (6 to < 10 years)\r\n* No greater than 1.2 mg/dL (10 to < 13 years)\r\n* No greater than 1.4 mg/dL (>= 13 years [female])\r\n* No greater than 1.5 mg/dL (13 to < 16 years [male])\r\n* No greater than 1.7 mg/dL (>= 16 years [male])Xx_NEWLINE_xXSerum creatinine > 1.5 mg/dLXx_NEWLINE_xXSerum creatinine ? 2.0mg/dL.Xx_NEWLINE_xXSerum bilirubin > 25 umol/L (1.5 mg/dL)Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dlXx_NEWLINE_xXCreatinine < 1.5 mg/dLXx_NEWLINE_xXTotal creatinine =< 2.5 mg/dLXx_NEWLINE_xXSerum Creatinine =< to 1.6 mg/dlXx_NEWLINE_xXSerum creatinine =< to 1.6 mg/dlXx_NEWLINE_xXSerum creatinine < 2.5 mg/dLXx_NEWLINE_xXMagnesium >= 1.6 mg/dLXx_NEWLINE_xXPotassium >= 3.5 mg/dLXx_NEWLINE_xXSerum creatinine > 2 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL OR 1.5 x institutional normalXx_NEWLINE_xXCreatinine clearance >= 70mL/min/1.73m^2 or serum creatinine based on age/gender as follows:\r\n* =< 0.4 mg/dl (age 1 month to < 6 months)\r\n* =< 0.5 mg/dl (age 6 months to < 1 year)\r\n* =< 0.6 mg/dl (age 1 year to < 2 years)\r\n* =< 0.5 mg/dl (age 2 years to < 6 years)\r\n* =< 1.0 mg/dl (age 6 years to < 10 years)\r\n* =< 1.2 mg/dl (age 10 years to < 13 years)\r\n* =< 1.4 mg/dl (females >= 13 years)\r\n* =< 1.5 mg/dl (males 13 years to < 16 years)\r\n* =< 1.7 mg/dl (males >= 16 years)Xx_NEWLINE_xXCreatinine < 1.7 mg/dLXx_NEWLINE_xXSerum creatinine < 1.5 mg/dlXx_NEWLINE_xXHave serum creatinine < 2.0 mg/dl =< 120 days prior to registrationXx_NEWLINE_xXSerum creatinine > 2.5 mg/dLXx_NEWLINE_xXSerum creatinine >= 2.0 mg/dLXx_NEWLINE_xXCreatinine > 2 mg/dLXx_NEWLINE_xXA serum creatinine based on age/gender as follows:\r\n* 1 to < 2 years: maximum serum creatinine 0.6 mg/dL (both male and female)\r\n* 2 to < 6 years: maximum serum creatinine 0.8 mg/dL (both male and female)\r\n* 6 to < 10 years: maximum serum creatinine 1 mg/dL (both male and female)\r\n* 10 to < 13 years: maximum serum creatinine 1.2 mg/dL (both male and female)\r\n* 13 to < 16 years: maximum serum creatinine 1.5 mg/dL (male), 1.4 mg/dL (female)\r\n* >= 16 years: maximum serum creatinine 1.7 mg/dL (male), 1.4 mg/dL (female)\r\nORXx_NEWLINE_xXCreatinine ? 1.5 mg/dlXx_NEWLINE_xXPatients with plasma creatinine level greater than 1.3 mg/dLXx_NEWLINE_xXSerum creatinine < 1.5 mg/dLXx_NEWLINE_xXSerum creatinine < 1.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dLXx_NEWLINE_xXCreatinine: =< 2.0 mg/dLXx_NEWLINE_xXSubjects with hypercalcemia (> 10.5 mg/dL)Xx_NEWLINE_xXSerum creatinine < 1.5 mg/dlXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dlXx_NEWLINE_xXSerum bilirubin =< 1.0 mg/dLXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 OR a serum creatinine based on age/gender as follows:\r\n* =< 0.4 mg/dL (age 1 month to < 6 months)\r\n* =< 0.5 mg/dL (age 6 months to < 1 year)\r\n* =< 0.6 mg/dL (age 1 to < 2 years)\r\n* =< 0.8 mg/dL (age 2 to < 6 years)\r\n* =< 1 mg/dL (age 6 to < 10 years)\r\n* =< 1.2 mg/dL (age 10 to < 13 years)\r\n* =< 1.4 mg/dL (females age >= 13 years)\r\n* =< 1.5 mg/dL (males age 13 to < 16 years)\r\n* =< 1.7 mg/dL (males age >= 16 years)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 OR a serum creatinine based on age/gender as follows:\r\n* 0.4 mg/dL (1 month to < 6 months of age)\r\n* 0.5 mg/dL (6 months to < 1 year of age)\r\n* 0.6 mg/dL (1 to < 2 years of age)\r\n* 0.8 mg/dL (2 to < 6 years of age)\r\n* 1.0 mg/dL (6 to < 10 years of age)\r\n* 1.2 mg/dL (10 to < 13 years of age)\r\n* 1.5 mg/dL (male) or 1.4 mg/dL (female) (13 to < 16 years of age)\r\n* 1.7 mg/dL (male) or 1.4 mg/dL (female) (>= 16 years of age)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) > 70 mL/min/1.73 m^2 OR serum creatinine based on age/gender as follows:            \r\n* 0.5 mg/dL (6 months to < 1 year of age)\r\n* 0.6 mg/dL (1 to < 2 years of age)\r\n* 0.8 mg/dL (2 to < 6 years of age)\r\n* 1.0 mg/dL (6 to < 10 years of age)\r\n* 1.2 mg/dL (10 to < 13 years of age)\r\n* 1.5 mg/dL (male)/1.4 mg/dL (female) (13 to < 16 years of age)\r\n* 1.7 mg/dL (male)/1.4 mg/dL (female) (>= 16 years of age)Xx_NEWLINE_xXSerum creatinine =< 2 mg/dLXx_NEWLINE_xXPatients with plasma creatinine level greater than 1.3 mg/dLXx_NEWLINE_xXSerum calcium <9.8 mg/dLXx_NEWLINE_xXSevere renal failure (serum creatinine > 3.0 mg/dL) within 6 months of study registrationXx_NEWLINE_xXSerum creatinine >1.2 mg/dLXx_NEWLINE_xXCreatinine < 2.0 mg/dlXx_NEWLINE_xXCreatinine =< 1.6 mg/dl (for patients with > 1.6 mg/dl, calculated or measured creatinine clearance must be >= 60 mL/minute [Cockcroft-Gault])Xx_NEWLINE_xXSerum creatinine < 2.0 mg/dlXx_NEWLINE_xXSerum creatinine < 1.5 mg/dlXx_NEWLINE_xXSerum creatinine > 2 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dLXx_NEWLINE_xXCreatinine ? 1.2 mg/dLXx_NEWLINE_xXSerum magnesium >= 1.8 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine equal to or less than 2 mg/dlXx_NEWLINE_xXSerum creatinine =< 2 mg/dLXx_NEWLINE_xXSerum creatinine (Cr) =< 2 gm/dLXx_NEWLINE_xXCreatinine =< 1.5 mg/dlXx_NEWLINE_xXGENERAL INCLUSION CRITERIA FOR SUBPROTOCOLS: Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:\r\n* Age: 1 to < 2 years; maximum serum creatinine (mg/dL): male 0.6; female 0.6\r\n* Age: 2 to < 6 years; maximum serum creatinine (mg/dL): male 0.8; female 0.8\r\n* Age: 6 to < 10 years; maximum serum creatinine (mg/dL): male 1; female 1\r\n* Age: 10 to < 13 years; maximum serum creatinine (mg/dL): male 1.2; female 1.2\r\n* Age: 13 to < 16 years; maximum serum creatinine (mg/dL): male 1.5; female 1.4\r\n* Age: >= 16 years; maximum serum creatinine (mg/dL): male 1.7; female 1.4Xx_NEWLINE_xXSerum bilirubin =< 2.0 mg/dL within 28 days prior to registrationXx_NEWLINE_xXCreatinine =< 1.4 mg/dLXx_NEWLINE_xXCreatinine < 2.0 mg/dlXx_NEWLINE_xXCreatinine < 1.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.4 mg/dlXx_NEWLINE_xXSerum creatinine: =< 2.0 mg/dLXx_NEWLINE_xXWithin 28 days prior to signing consent: Serum creatinine > 2.0 mg/dL or 177 umol/LXx_NEWLINE_xXCreatinine =< 2.0 mg/dlXx_NEWLINE_xXBilirubin =< 1.5 mg/dL (or =< 3.0 mg/dL for patients with Gilbert’s syndrome)Xx_NEWLINE_xXSerum creatinine < 1.5 mg/dlXx_NEWLINE_xXSerum bilirubin must be ? 2.0 mg/dlXx_NEWLINE_xXSerum bilirubin must be ? 2.0 mg/dlXx_NEWLINE_xXCreatinine < 2.0 mg/ldXx_NEWLINE_xXCreatinine >= 1.4 mg/dLXx_NEWLINE_xXSerum creatinine >= 1.4 mg/dlXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dlXx_NEWLINE_xXHypo- (calcium [Ca] < 8.5 mg/dL) or hyper-calcemia (Ca > 10.5 mg/dL)Xx_NEWLINE_xXCreatinine =< 3.0 mg/dLXx_NEWLINE_xXRenal insufficiency with recent (< 3 month old) creatinine > 2.0 mg/dLXx_NEWLINE_xXCreatinine < 2 mg/dLXx_NEWLINE_xXPatients with a blood creatinine level > 2.0 mg/dl within a month of this procedureXx_NEWLINE_xXDiabetic patients with a blood creatinine level > 1.5 mg/dl within a month of this procedureXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL (133 umol/L), or, if greater than 1.5 mg/dL: calculated creatinine clearance >= 50 mL/min (evaluated within 28 days of randomization)Xx_NEWLINE_xXRecent lab tests showing elevated serum creatinine (>= 1.5 mg/dL)Xx_NEWLINE_xXPatients with impaired kidney function (creatinine >= 1.3 mg/dL or < 0.6 mg/dL)Xx_NEWLINE_xXCreatinine > 1.3 mg/dlXx_NEWLINE_xXSerum creatinine > 2.5 mg/dLXx_NEWLINE_xXSerum calcium > 11 mg/dLXx_NEWLINE_xXCreatinine > 2.5 mg/dLXx_NEWLINE_xXSerum creatinine > 3.0 mg/dL (270 uM/L)Xx_NEWLINE_xXCreatinine =< 2.0 mg/dlXx_NEWLINE_xXCreatinine < 2.0 mg/dLXx_NEWLINE_xXCreatinine < 2.0 mg/ dLXx_NEWLINE_xXSerum creatinine based on age/gender as follows: (threshold creatinine values were derived from the Schwartz formula for estimating GFR)\r\n* 12 to < 13 years; 1.2 mg/DL (male and female)\r\n* 13 to < 16 years; 1.5 mg/DL (male) and 1.4 mg/DL (female)\r\n* >= 16 years; 1.7 mg/DL (male) and 1.4 mg/DL (female)Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL, within 2 weeks prior to study startXx_NEWLINE_xXSerum creatinine > 2.5 mg/dLXx_NEWLINE_xXSerum bilirubin =< 2.0 mg/dlXx_NEWLINE_xXSerum creatinine > 2.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL, obtained within 2 weeks prior to registrationXx_NEWLINE_xXSerum creatinine < 1.6 mg/dLXx_NEWLINE_xXCreatinine <3.0 mg/dlXx_NEWLINE_xXHave a serum creatinine =< 1.0 mg/dLXx_NEWLINE_xXCreatinine =< 1.5 mg/dLXx_NEWLINE_xXSerum bilirubin =< 1.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dLXx_NEWLINE_xXCreatinine < 1.4 mg/dl for females or < 1.5 mg/dl for malesXx_NEWLINE_xXCreatinine < (1.5 mg/dL) at the screening visitXx_NEWLINE_xXPatients with plasma creatinine level greater than 1.3 mg/dLXx_NEWLINE_xXSerum/plasma creatinine ?1.5mg/dL.Xx_NEWLINE_xX