History of interstitial lung disease or pneumonitis requiring supplemental oxygen or treatment with oral or intravenously administered corticosteroidsXx_NEWLINE_xXKnown interstitial lung disease, interstitial fibrosis, or history of tyrosine kinase inhibitor-induced pneumonitisXx_NEWLINE_xXPatients with interstitial lung disease and/or pneumonitis are not eligibleXx_NEWLINE_xXPatients must not have symptomatic interstitial lung disease or pneumonitisXx_NEWLINE_xXPatients must not have a history of pneumonitis or interstitial lung diseaseXx_NEWLINE_xXPatients must not have evidence of interstitial lung disease or pneumonitisXx_NEWLINE_xXParticipants may not have clinically active or symptomatic interstitial lung disease or interstitial pneumonitis (i.e., affecting activities of daily living or requiring therapeutic intervention), or a history of clinically significant interstitial lung disease or radiation pneumonitisXx_NEWLINE_xXSubjects with a history of interstitial lung disease and/or pneumonitisXx_NEWLINE_xXHave evidence of interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity or active, noninfectious pneumonitis.Xx_NEWLINE_xXEvidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or chronic pneumonitisXx_NEWLINE_xXEvidence of clinically significant interstitial lung disease or active, noninfectious pneumonitis.Xx_NEWLINE_xXInterstitial lung disease or pneumonitis that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity; patients with prior pneumonitis that has resolved are eligible (for treatment phase)Xx_NEWLINE_xXHistory of interstitial lung disease (e.g., pneumonitis or pulmonary fibrosis)Xx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXParticipants with current pneumonitis or interstitial lung diseaseXx_NEWLINE_xXInterstitial lung disease or history of pneumonitis requiring treatment with corticosteroidsXx_NEWLINE_xXHistory of pneumonitis or other interstitial lung diseaseXx_NEWLINE_xXHistory of interstitial lung disease (ILD), drug-induced ILD, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung diseaseXx_NEWLINE_xXEvidence of clinically significant interstitial lung disease or active, noninfectious pneumonitis.Xx_NEWLINE_xXHas active pneumonitis requiring treatment with steroids or active interstitial lung diseaseXx_NEWLINE_xXKnown interstitial lung disease, interstitial fibrosis, or history of tyrosine kinase inhibitor-induced pneumonitis. Patients with a history of prior radiation pneumonitis are not excluded.Xx_NEWLINE_xXHistory of or active pneumonitis or interstitial lung disease:\r\n* For history of pneumonitis to be an exclusion, patient had to have required supplemental oxygen or corticosteroid treatment; radiographic changes alone are not an exclusionXx_NEWLINE_xXThe subject has any history or evidence of active, non-infectious pneumonitis or interstitial lung diseaseXx_NEWLINE_xXPatients with history of interstitial lung disease or pneumonitis.Xx_NEWLINE_xXSAFETY RUN-IN: Has evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXRANDOMIZED PHASE II CLINICAL TRIAL: Has evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHas history of interstitial lung disease or non-infectious pneumonitis except for those induced by radiation therapies.Xx_NEWLINE_xXHistory of pneumonitis or interstitial lung disease.Xx_NEWLINE_xXHistory of interstitial lung disease or pneumonitis.Xx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXPatients with blood oxygen saturation < 90% at rest; patients must not have symptomatic interstitial lung disease, pneumonitis, or known pulmonary fibrosisXx_NEWLINE_xXParticipants with a history of interstitial lung disease (ILD) / pneumonitisXx_NEWLINE_xXHas a history of (non-infectious) pneumonitis /interstitial lung disease that required steroids or has current pneumonitis/interstitial lung disease that requires steroids.Xx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXKnown non-infectious pneumonitis or any history of interstitial lung diseaseXx_NEWLINE_xXCurrently active pneumonitis or interstitial lung disease.Xx_NEWLINE_xXEvidence of clinically significant interstitial lung disease or active, noninfectious pneumonitis.Xx_NEWLINE_xXHistory of interstitial lung disease, pneumonitis or other clinically significant lung diseases.Xx_NEWLINE_xXPatients with any evidence of current interstitial lung disease (ILD) or pneumonitisXx_NEWLINE_xXEvidence of interstitial lung disease or noninfectious pneumonitis.Xx_NEWLINE_xXHistory of interstitial lung disease or pneumonitis that has required steroid administrationXx_NEWLINE_xXHistory of interstitial lung disease, history of slowly progressive dyspnea and unproductive cough, sarcoidosis, silicosis, idiopathic pulmonary fibrosis, pulmonary hypersensitivity pneumonitis or multiple allergies.Xx_NEWLINE_xXHistory of adrenal insufficiency, pneumonitis, interstitial lung disease, or inflammatory bowel diseaseXx_NEWLINE_xXThe participant has any history or evidence of active, non-infectious pneumonitis or interstitial lung diseaseXx_NEWLINE_xXHistory of interstitial pneumonitisXx_NEWLINE_xXSubjects with a history of interstitial lung disease; patients requiring continuous supplemental oxygen are excluded to avoid possible complications from pneumonitisXx_NEWLINE_xXHistory of pneumonitis or interstitial lung diseaseXx_NEWLINE_xXHas interstitial lung disease or a history of pneumonitis that required oral or intravenous glucocorticoids to assist with management.Xx_NEWLINE_xXPrevious severe hypersensitivity reaction to another monoclonal antibody, such as colitis or pneumonitis requiring treatment with steroids, or has a history of interstitial lung disease.Xx_NEWLINE_xXInterstitial lung disease, sarcoidosis, silicosis, idiopathic pulmonary fibrosis, or pulmonary hypersensitivity pneumonitisXx_NEWLINE_xXEvidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXCurrent or history of interstitial pneumonitis,Xx_NEWLINE_xXHistory of interstitial lung disease and/or pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease (eg, pneumonitis or pulmonary fibrosis) or evidence of interstitial lung disease on baseline chest computed tomography (CT) scanXx_NEWLINE_xXHistory of interstitial lung disease or interstitial pneumonitis, including clinically significant radiation pneumonitisXx_NEWLINE_xXPatients with active interstitial lung disease and non-infectious pneumonitis or a history of active interstitial lung disease or pneumonitis requiring treatment with steroids or that may interfere with the detection or management of suspected drug-related pulmonary toxicity. Patients with lung cancer with a remote history of pneumonitis following chemo-radiation treatment that has resolved are allowed.\r\n* Note: Patients with chronic obstructive pulmonary disease (COPD) whose disease is controlled (per investigator judgment) at trial entry are not excluded.Xx_NEWLINE_xXSubjects with active interstitial pneumonitis.Xx_NEWLINE_xXEXCLUSION - DURVALUMAB DRUG-SPECIFIC: Participant has evidence of interstitial lung disease or active non-infectious pneumonitis.Xx_NEWLINE_xXHas evidence of current interstitial lung disease (ILD) or pneumonitis or a prior history of ILD or pneumonitis requiring oral or intravenous glucocorticoidsXx_NEWLINE_xXKnown history of, or any evidence of, interstitial lung disease or active noninfectious pneumonitisXx_NEWLINE_xXPatient has history of interstitial lung disease or interstitial pneumonitis, including clinically significant radiation pneumonitis (i.e., affecting activities of daily living or requiring therapeutic intervention). (Note, this does NOT include immune-mediated pneumonitis)Xx_NEWLINE_xXEvidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHistory of pneumonitis or interstitial lung disease (ILD).Xx_NEWLINE_xXHas known history of, or any evidence of active, interstitial lung disease or non-infectious pneumonitis requiring corticosteroid therapyXx_NEWLINE_xXSignificant pulmonary disease, including pulmonary hypertension or interstitial pneumonitisXx_NEWLINE_xXActive interstitial lung disease (ILD)/pneumonitis or a prior history of ILD/pneumonitis requiring treatment with steroids.Xx_NEWLINE_xXPast medical history of interstitial lung disease (ILD), drug-induced ILD, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung diseaseXx_NEWLINE_xXPatients with a known history of severe interstitial lung disease or severe pneumonitis or active pneumonitis/pneumonia or pulmonary pathology that is not well controlled in the opinion of the treating physician and/or principal investigator (PI).Xx_NEWLINE_xXPresence of cavitation of central pulmonary lesion, or radiographic evidence of pneumonitis or other extensive bilateral lung disease such as interstitial lung diseaseXx_NEWLINE_xXPatients with evidence of interstitial lung disease or active, non-infectious pneumonitis; patients with a history of interstitial lung disease or non-infectious pneumonitis requiring treatment with steroids are also excludedXx_NEWLINE_xXPatients with evidence of non-infectious pneumonitis or history of interstitial lung diseaseXx_NEWLINE_xXHistory of (noninfectious) pneumonitis that required systemic steroids or current pneumonitis/interstitial lung disease.Xx_NEWLINE_xXEvidence of active interstitial lung disease or active non-infectious pneumonitisXx_NEWLINE_xXParticipants with clinically active or symptomatic interstitial lung disease or interstitial pneumonitis (i.e., affecting activities of daily living or requiring therapeutic intervention) and patients with history of clinically significant interstitial lung disease or radiation pneumonitisXx_NEWLINE_xXHistory of medically diagnosed pneumonitis or interstitial lung diseaseXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitis.Xx_NEWLINE_xXAny evidence of current interstitial lung disease (ILD) or pneumonitis or a prior history of ILD or pneumonitis requiring oral or IV glucocorticoidsXx_NEWLINE_xXHas a known history of, or any evidence of, interstitial lung disease or active non- infectious pneumonitisXx_NEWLINE_xXA history of pneumonitis or extensive bilateral lung disease of non-malignant etiology.Xx_NEWLINE_xXHistory of interstitial pneumonitis or pulmonary fibrosis, or evidence of interstitial pneumonitis or pulmonary fibrosis on baseline chest CT scanXx_NEWLINE_xXHas any history of interstitial lung disease (pulmonary fibrosis or severe radiation pneumonitis) or is suspected to have such disease by imaging during screening.Xx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitis, or has history of pneumonitis that required systemic corticosteroids for recoveryXx_NEWLINE_xXHistory of pneumonitis or drug-related inflammatory lung diseaseXx_NEWLINE_xXPatients with a history of interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of extensive, disseminated, bilateral or presence of grade 3 or 4 interstitial fibrosis or interstitial lung disease including pneumonitis, hypersensitivity pneumonitis, interstitial pneumonia, interstitial lung disease, obliterative bronchiolitis or pulmonary fibrosis; patients with history of prior radiation pneumonitis are not excludedXx_NEWLINE_xXHistory of pneumonitis or interstitial lung diseaseXx_NEWLINE_xXPatient with active interstitial lung disease (ILD)/pneumonitis or a prior history of ILD/pneumonitis requiring treatment with steroidsXx_NEWLINE_xXHave evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHistory or clinically confirmed pneumonitis or interstitial lung diseaseXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory or the presence of pulmonary interstitial disease, or drug-related pneumonitisXx_NEWLINE_xXPatient has history of interstitial lung disease or interstitial pneumonitis, including clinically significant radiation pneumonitis (i.e., affecting activities of daily living or requiring therapeutic intervention)Xx_NEWLINE_xXActive or prior documented history of pneumonitis or interstitial lung diseaseXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXEvidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHas a history of interstitial lung disease, non-infectious pneumonitis or pneumonitisXx_NEWLINE_xXHas a history of interstitial lung disease or pneumonitis from any causeXx_NEWLINE_xXKnown history or evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXPatients with a known history of severe interstitial lung disease or severe pneumonitis or active pneumonitis/pneumonia or pulmonary pathology that is not well controlled in the opinion of the treating physician and/or principal investigator (PI)Xx_NEWLINE_xXHistory and/or confirmed interstitial lung disease (ILD)/pneumonitis, extensive bilateral lung disease on high-resolution computed tomography (HRCT) scanXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXHas interstitial lung disease or a history of pneumonitis that required oral or intravenous glucocorticoids to assist with management; lymphangitic spread of the NSCLC is not exclusionaryXx_NEWLINE_xXHistory of extensive interstitial lung disease, e.g., pneumonitis or pulmonary fibrosis or any evidence of extensive interstitial lung disease on baseline chest computed tomography (CT) scanXx_NEWLINE_xXHas history of/active pneumonitis that required/is requiring steroid treatment or had history of/active interstitial lung disease; has an active infection requiring systemic treatmentXx_NEWLINE_xXHistory of pneumonitis or interstitial lung diseaseXx_NEWLINE_xXPatients with a history of pneumonitis or interstitial lung diseaseXx_NEWLINE_xXPatients with history of interstitial lung disease or active, non-infectious pneumonitis are not eligible\r\n* NOTE: history of radiation pneumonitis in the radiation field (fibrosis) is permittedXx_NEWLINE_xXHave evidence of interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity or active, noninfectious pneumonitis.Xx_NEWLINE_xXSignificant pulmonary disease, including pulmonary hypertension, interstitial lung disease, or active, non-infectious pneumonitisXx_NEWLINE_xXPast medical history of interstitial lung disease (ILD), drug-induced ILD, radiation pneumonitis requiring steroid treatment, or any evidence of clinically active ILDXx_NEWLINE_xXHas known history of/active pneumonitis requiring treatment with steroids or history of/active interstitial lung diseaseXx_NEWLINE_xXHave evidence of interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity or active, noninfectious pneumonitis.Xx_NEWLINE_xXKnown prior history of interstitial pneumonitis, including clinically significant radiation pneumonitis (i.e. affecting activities of daily living or requiring therapeutic intervention)Xx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHas a history of interstitial lung disease or pneumonitis.Xx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXEvidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease/pneumonitisXx_NEWLINE_xXCERITINIB EXCLUSION CRITERIA: Known history of extensive disseminated bilateral interstitial fibrosis or interstitial lung disease, including a history of pneumonitis, hypersensitivity pneumonitis, interstitial pneumonia, obliterative bronchiolitis, and clinically significant radiation pneumonitisXx_NEWLINE_xXREGORAFENIB EXCLUSION CRITERIA: Known history of extensive disseminated bilateral interstitial fibrosis or interstitial lung disease, including a history of pneumonitis, hypersensitivity pneumonitis, interstitial pneumonia, obliterative bronchiolitis, and clinically significant radiation pneumonitisXx_NEWLINE_xXENTRECTINIB EXCLUSION CRITERIA: Known history of extensive disseminated bilateral interstitial fibrosis or interstitial lung disease, including a history of pneumonitis, hypersensitivity pneumonitis, interstitial pneumonia, obliterative bronchiolitis, and clinically significant radiation pneumonitisXx_NEWLINE_xXHistory of pneumonitis or active lung infectionXx_NEWLINE_xXPatient has history of interstitial lung disease or interstitial pneumonitis, including clinically significant radiation pneumonitis (i.e., affecting activities of daily living or requiring therapeutic intervention)Xx_NEWLINE_xXPresence or history of interstitial lung disease or interstitial pneumonitis, including clinically significant radiation pneumonitisXx_NEWLINE_xXPast history of interstitial lung disease (ILD), drug induced ILD, radiation pneumonitis that required steroid treatment, or any evidence of clinically active ILD.Xx_NEWLINE_xXEvidence of interstitial lung disease or active non-infectious pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXPHASE II COLORECTAL CANCER COHORT 6 (MEDI+C ONLY):\r\nPatients with prior history of pneumonitis and/or interstitial lung disease will be excludedXx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXSubject has evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXPatients with a known history of severe interstitial lung disease or severe pneumonitis or active pneumonitis that is uncontrolled in the opinion of the treating physicianXx_NEWLINE_xXHistory of interstitial lung disease, history of slowly progressive dyspnea and unproductive cough, sarcoidosis, silicosis, idiopathic pulmonary fibrosis or pulmonary hypersensitivity pneumonitisXx_NEWLINE_xXInterstitial lung disease or pneumonitisXx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitis that required oral or intravenous glucocorticoids to assist with management; lymphangitic spread of the non-small cell lung cancer (NSCLC) is not exclusionaryXx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXPatients with known history of extensive disseminated bilateral interstitial fibrosis or interstitial lung disease, including a history of pneumonitis, hypersensitivity pneumonitis, interstitial pneumonia, obliterative bronchiolitis, and clinically significant radiation pneumonitis (i.e. affecting activities of daily living or requiring therapeutic intervention)Xx_NEWLINE_xXEvidence of pre-existing interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXPatient has history of interstitial lung disease or interstitial pneumonitis, including clinically significant radiation pneumonitis (i.e., affecting activities of daily living or requiring therapeutic intervention)Xx_NEWLINE_xXPatients with known history of extensive disseminated bilateral interstitial fibrosis or interstitial lung disease, including a history of pneumonitis, hypersensitivity pneumonitis, interstitial pneumonia, obliterative bronchiolitis, and clinically significant radiation pneumonitis (i.e., affecting activities of daily living or requiring therapeutic intervention)Xx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXPatient with a history of interstitial lung disease, history of slowly progressive dyspnea, sarcoidosis, silicosis, idiopathic pulmonary fibrosis or pulmonary hypersensitivity pneumonitisXx_NEWLINE_xXPatient has history of interstitial lung disease or known history of, or any evidence of active, noninfectious pneumonitisXx_NEWLINE_xXCurrently have or have a history of interstitial lung disease, drug-related pneumonitis, or radiation pneumonitis that required steroid treatment.Xx_NEWLINE_xXHistory of treatment-related interstitial lung disease/pneumonitisXx_NEWLINE_xXEvidence of interstitial lung disease or active pneumonitisXx_NEWLINE_xXKnown history of, or any evidence of interstitial lung disease, non-infectious pneumonitis, pulmonary fibrosis diagnosed based on imaging or clinical findings, or uncontrolled systemic diseases, including diabetes, hypertension, acute lung diseases, etcXx_NEWLINE_xXHistory of interstitial lung disease or non-infectious pneumonitis, unless induced by radiation therapyXx_NEWLINE_xXPast medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease and/or immune mediated pneumonitisXx_NEWLINE_xXHas a medical history of clinically significant lung diseases (eg, interstitial pneumonia, pneumonitis, pulmonary fibrosis, and severe radiation pneumonitis) or who are suspected to have these diseases by imaging at screening periodXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXSubjects must not have evidence of pneumonitis or inflammatory lung disease on CT scan and x-rayXx_NEWLINE_xXHas evidence of interstitial lung disease, active, non-infectious pneumonitisXx_NEWLINE_xXPatients with known history of interstitial lung disease or idiopathic pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease (ILD)/pneumonitis requiring treatment with steroids and patients with active ILD/pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of or active, non-infectious pneumonitis and/or a history of interstitial lung diseaseXx_NEWLINE_xXTREATMENT: Patients with current or a history of interstitial lung disease, known severely impaired lung function (spirometry and carbon monoxide diffusing capability test (DLCO) 50% or less of normal and oxygen [O2] saturation 88% or less at rest on room air) or non-infectious pneumonitis will not be assigned treatment with everolimus or trametinib DMSO; symptoms should have resolved and course of antibiotics been completed for patients with a history of infectious pneumonitis to be eligibleXx_NEWLINE_xXSubjects with any history of interstitial lung disease or a history of > or = to grade 2 radiation pneumonitisXx_NEWLINE_xXDOSE ESCALATION COHORT: Evidence of or any history of interstitial lung disease or active, noninfectious pneumonitis including symptomatic and/or pneumonitis requiring treatmentXx_NEWLINE_xXDOSE EXPANSION COHORT: Evidence of or any history of interstitial lung disease or active, noninfectious pneumonitis including symptomatic and/or pneumonitis requiring treatmentXx_NEWLINE_xXPatients with evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHas evidence of interstitial lung disease, active non-infectious pneumonitis, or a history of grade 3 or greater pneumonitisXx_NEWLINE_xXInterstitial lung disease or pneumonitis not secondary to ECDXx_NEWLINE_xXSignificant pulmonary disease, including pulmonary hypertension or interstitial pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXPatients with a history of interstitial lung disease or pneumonitisXx_NEWLINE_xXPatient must not have a history of interstitial lung disease or pneumonitisXx_NEWLINE_xXKnown history of, or any evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXEvidence of interstitial lung disease or active, noninfectious pneumonitisXx_NEWLINE_xXHistory of extensive, disseminated, bilateral or presence of Grade 3 or 4 interstitial fibrosis or interstitial lung disease including a history of pneumonitis, hypersensitivity pneumonitis, interstitial pneumonia, interstitial lung disease, obliterative bronchiolitis and pulmonary fibrosis.Xx_NEWLINE_xXCLINICAL/LABORATORY CRITERIA: Patient must not have prior history of interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease (e.g. pneumonitis or pulmonary fibrosis) or evidence of interstitial lung disease on baseline chest CT scanXx_NEWLINE_xXHistory or evidence of active, non-infectious pneumonitis or interstitial lung diseaseXx_NEWLINE_xXEvidence of active, noninfectious pneumonitis or history of interstitial lung disease.Xx_NEWLINE_xXPatients with a history of interstitial lung disease or pneumonitisXx_NEWLINE_xXSubject has a history of pneumonitis or interstitial lung disease. Hepatocellular Carcinoma Exclusion Criterion:Xx_NEWLINE_xXHas interstitial lung disease or a history of pneumonitis that required oral of IV glucocorticoids to assist with management.Xx_NEWLINE_xXKnown interstitial lung disease, interstitial fibrosis, or history of tyrosine kinase inhibitor-induced pneumonitis.Xx_NEWLINE_xXEvidence of active non-infectious pneumonitis/interstitial lung diseaseXx_NEWLINE_xXSubject has interstitial lung disease or a history of pneumonitisXx_NEWLINE_xXNo symptomatic pulmonary fibrosis or interstitial pneumonitis >= grade 2Xx_NEWLINE_xXHave a history or the presence at baseline of pulmonary interstitial disease, drug-related pneumonitis, or radiation pneumonitis.Xx_NEWLINE_xXInterstitial lung disease (subjects with existing pneumonitis as a result of radiation are not excluded, however, subjects cannot be oxygen dependent).Xx_NEWLINE_xXInterstitial lung disease or pneumonitis requiring oral or IV glucocorticoidsXx_NEWLINE_xXCurrent or history of pneumonitis or interstitial lung diseaseXx_NEWLINE_xXHas evidence or history of interstitial lung disease or active noninfectious pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease (e.g. pneumonitis or pulmonary fibrosis) or evidence of interstitial lung disease on baseline chest computed tomography (CT) scanXx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHas interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHas history of interstitial lung disease or non-infectious pneumonitis except for those induced by radiation therapies..Xx_NEWLINE_xXPatients with a known history of severe interstitial lung disease or severe pneumonitis or active pneumonitis that is uncontrolled in the opinion of the treating physicianXx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXPresence or history of interstitial lung disease or interstitial pneumonitisXx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXInterstitial lung disease or pneumonitis that has required oral or IV steroidsXx_NEWLINE_xXHistory of interstitial lung disease or unresolved pneumonitisXx_NEWLINE_xXHas history of interstitial lung disease or pneumonitis.Xx_NEWLINE_xXInterstitial lung disease, or history of pneumonitis requiring systemic steroids for treatmentXx_NEWLINE_xXEvidence of active noninfectious pneumonitis or history of interstitial lung disease.Xx_NEWLINE_xXHistory of or current drug-induced interstitial lung disease or pneumonitis grade ?2Xx_NEWLINE_xXHistory of interstitial lung disease or unresolved pneumonitisXx_NEWLINE_xXHistory of pneumonitis or interstitial lung disease, or any unresolved immune-related adverse events.Xx_NEWLINE_xXHistory of drug-induced interstitial lung disease (ILD), ILD, or radiation pneumonitis requiring treatment with steroid prior to study enrollment, or any evidence of clinically active ILD.Xx_NEWLINE_xXPatients with active interstitial pneumonitisXx_NEWLINE_xXHas known history of/active, non-infectious pneumonitis requiring treatment with steroids or has history of/active interstitial lung diseaseXx_NEWLINE_xXParticipant has history of interstitial lung disease (ILD) OR a history of pneumonitis that has required oral or IV steroids. Participants whose pneumonitis was solely as a result of radiation therapy for their NSCLC would not be excluded from the study unless they received oral/IV steroids to manage the pneumonitis.Xx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXPast history of interstitial lung disease (ILD), drug-induced ILD, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease.Xx_NEWLINE_xXHistory of interstitial lung disease, pneumonitis, autoimmune disease or syndrome that requires steroids or immunosuppressive agents.Xx_NEWLINE_xXHas evidence of interstitial lung disease, any active, non-infectious pneumonitis, or known active tuberculosisXx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHistory of pneumonitis or interstitial lung disease.Xx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXInterstitial lung disease or history of pneumonitis requiring treatment with corticosteroidsXx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXEvidence of interstitial lung disease or active non-infectious pneumonitisXx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXSignificant pulmonary disease, including pulmonary hypertension or interstitial pneumonitisXx_NEWLINE_xXHas history of interstitial lung disease or active, non-infectious pneumonitis requiring steroidsXx_NEWLINE_xXEvidence of interstitial lung disease or active non-infectious pneumonitisXx_NEWLINE_xXHave a history or the presence of pulmonary interstitial disease or drug-related pneumonitis.Xx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXPresence of interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXSubjects with a history of pneumonitis or interstitial lung diseaseXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease e.g. pneumonitis or pulmonary fibrosis or evidence of interstitial lung disease on baseline chest computed tomography (CT) scanXx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitis, or has history of pneumonitis that required systemic corticosteroids for recoveryXx_NEWLINE_xXConfirmed pneumonitis or interstitial lung diseaseXx_NEWLINE_xXA history of clinically significant interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease e.g. pneumonitis or pulmonary fibrosis or evidence of interstitial lung disease on baseline chest computed tomography (CT) scanXx_NEWLINE_xXHistory and/or confirmed pneumonitis or interstitial lung diseaseXx_NEWLINE_xXHistory of extensive interstitial lung disease e.g. pneumonitis or pulmonary fibrosis or any evidence of extensive interstitial lung disease on baseline chest computed tomography (CT) scanXx_NEWLINE_xXHistory of interstitial lung disease, or slowly progressive dyspnea and unproductive cough, sarcoidosis, silicosis, idiopathic pulmonary fibrosis, pulmonary hypersensitivity pneumonitis or multiple allergies.Xx_NEWLINE_xXHas a history of pneumonitis or idiopathic pulmonary fibrosis, or evidence of interstitial lung disease.Xx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXPresence of interstitial lung disease or history of pneumonitis requiring treatment with corticosteroidsXx_NEWLINE_xXHistory of interstitial lung disease/pneumonitis from any causeXx_NEWLINE_xXPatients with interstitial lung disease or active, noninfectious pneumonitisXx_NEWLINE_xXHave evidence of interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity or active, noninfectious pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease (ILD) eg, interstitial pneumonitis, pulmonary fibrosis or evidence of ILD on baseline chest computed tomography (CT) or magnetic resonance imaging (MRI)Xx_NEWLINE_xXSubjects with a history of interstitial lung disease, history of slowly progressive dyspnea and unproductive cough, sarcoidosis, silicosis, idiopathic pulmonary fibrosis, pulmonary hypersensitivity pneumonitis or multiple allergies.Xx_NEWLINE_xXHistory of interstitial pneumonitisXx_NEWLINE_xXHistory of interstitial pneumonitisXx_NEWLINE_xXHistory of interstitial pneumonitis and/or require supplemental oxygen therapyXx_NEWLINE_xXHistory of interstitial lung disease e.g. pneumonitis or pulmonary fibrosis or evidence of interstitial lung disease on baseline chest computed tomography (CT) scanXx_NEWLINE_xXPatients with interstitial pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitis of any causeXx_NEWLINE_xXHas a history of, active pneumonitis requiring treatment with steroids or history of/active interstitial lung diseaseXx_NEWLINE_xXPatients with known history of extensive disseminated bilateral interstitial fibrosis or interstitial lung disease, including a history of pneumonitis, hypersensitivity pneumonitis, interstitial pneumonia, obliterative bronchiolitis, and clinically significant radiation pneumonitis (i.e. affecting activities of daily living or requiring therapeutic intervention)Xx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitis.Xx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease, sarcoidosis, silicosis, idiopathic pulmonary fibrosis, or pulmonary hypersensitivity pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or active, non-infectious pneumonitis that required oral or intravenous corticosteroidsXx_NEWLINE_xXKnown preexisting interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease, sarcoidosis, silicosis, idiopathic pulmonary fibrosis, or pulmonary hypersensitivity pneumonitis.Xx_NEWLINE_xXPatients with a history of interstitial lung disease, history of slowly progressive dyspnea and unproductive cough, sarcoidosis, silicosis, interstitial pulmonary fibrosis, pulmonary hypersensitivity pneumonitis or multiple allergiesXx_NEWLINE_xXHistory of or known presence of extensive, disseminated/bilateral or Grade 3 or 4 interstitial fibrosis or interstitial lung disease, including a history of pneumonitis, hypersensitivity pneumonitis, interstitial pneumonia, interstitial lung disease, obliterative bronchiolitis, or pulmonary fibrosis, but not including a history of prior radiation pneumonitis. Patients with clinically significant lung disease requiring oxygen therapy (eg, COPD).Xx_NEWLINE_xXHistory of interstitial lung disease or pneumonitis.Xx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXActive pneumonitis or interstitial lung diseaseXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitis.Xx_NEWLINE_xXHistory of interstitial lung disease e.g. pneumonitis or pulmonary fibrosis or evidence of interstitial lung disease on baseline chest computed tomography (CT) scanXx_NEWLINE_xXClinically significant lung disease (including pneumonitis, interstitial lung disease, idiopathic pulmonary fibrosis, cystic fibrosis, active infection/ history of opportunistic infections)Xx_NEWLINE_xXKnown interstitial lung disease, drug-related pneumonitis, or radiation pneumonitis requiring steroid treatmentXx_NEWLINE_xXEvidence of active, noninfectious pneumonitis or history of interstitial lung disease.Xx_NEWLINE_xXPatient has history of interstitial lung disease or interstitial pneumonitis, including clinically significant radiation pneumonitis (i.e., affecting activities of daily living or requiring therapeutic intervention)Xx_NEWLINE_xXInterstitial lung disease (subjects with existing pneumonitis as a result of radiation are not excluded, however, subjects must not be oxygen dependent).Xx_NEWLINE_xXKnown history of, or any evidence of, interstitial lung disease or active noninfectious pneumonitis.Xx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXPast medical history of interstitial lung disease (ILD), drug-induced ILD, radiation pneumonitis which required steroid treatment, or any evidence of clinically active ILD.Xx_NEWLINE_xXHas evidence of interstitial lung disease or active, non-infectious pneumonitis; has an active infection requiring systemic therapyXx_NEWLINE_xXSubjects with a history or evidence of interstitial pneumonitis or pulmonary fibrosisXx_NEWLINE_xXPatients with a history or evidence of interstitial pneumonitis or pulmonary fibrosisXx_NEWLINE_xXHas any history of interstitial lung disease (pulmonary fibrosis or severe radiation pneumonitis) or is suspected to have such disease by imaging during screeningXx_NEWLINE_xXPatient has history of interstitial lung disease or interstitial pneumonitis, including clinically significant radiation pneumonitis (i.e., affecting activities of daily living or requiring therapeutic intervention).Xx_NEWLINE_xXHistory of extensive, disseminated, bilateral or presence of grade 3 or 4 interstitial fibrosis or interstitial lung disease including pneumonitis, hypersensitivity pneumonitis, interstitial pneumonia, interstitial lung disease, obliterative bronchiolitis and pulmonary fibrosis; patients with history of prior radiation pneumonitis are not excludedXx_NEWLINE_xXHistory of interstitial lung disease or pneumonitisXx_NEWLINE_xXHistory of extensive disseminated/bilateral or known presence of interstitial fibrosis or interstitial lung disease, including a history of pneumonitis, hypersensitivity pneumonitis, interstitial pneumonia, interstitial lung disease, obliterative bronchiolitis, and pulmonary fibrosis, but not history of prior radiation pneumonitis.Xx_NEWLINE_xXPatient has history of interstitial lung disease or interstitial pneumonitis, including clinically significant radiation pneumonitis (i.e., affecting activities of daily living or requiring therapeutic intervention).Xx_NEWLINE_xXHave history of interstitial lung disease or pneumonitis.Xx_NEWLINE_xXHas clinical or radiologic evidence of interstitial lung disease or active, non-infectious pneumonitisXx_NEWLINE_xX