Creatinine clearance of > 60 ml/min; creatinine clearance may be measured or calculated; if calculating, creatinine clearance, use the Cockroft-Gault formula =< 2 weeks prior to randomizationXx_NEWLINE_xXPARTICIPANTS NOT ON THE HODGKIN LYMPHOMA EXPANSION COHORT: Creatinine < 1.5 UNL or creatinine clearance (CrCl) > 50 ml/min, within 2 weeks prior to enrollmentXx_NEWLINE_xXSerum creatinine =< 1.2 x ULN or creatinine clearance >= 60 mL/min; obtained within 14 days prior to study entryXx_NEWLINE_xXCalculated serum creatinine clearance >= 60 mL/min/1.73 m^2, within 28 days prior to administration of study treatmentXx_NEWLINE_xXAdequate renal function determined within 6 weeks prior to randomization defined as the most recent serum creatinine =< ULN or measured or calculated creatinine clearance > 60 mL/minXx_NEWLINE_xXSTEP I: Calculated creatinine clearance >= 30 mL/min (obtained within 28 days prior to randomization)Xx_NEWLINE_xXSTEP II: Calculated creatinine clearance >= 30 mL/min (within 28 days prior to randomization to Step II)Xx_NEWLINE_xXSerum creatinine =< 1.5 times ULN OR calculated creatinine clearance >= 70 mL/minXx_NEWLINE_xXCalculated creatinine clearance > 30 ml/min within 14 days prior to step 2 randomizationXx_NEWLINE_xXSerum creatinine =< 1.5 x mg/dL OR measured or calculated creatinine clearance >= 50 mL/min; creatinine measurements must be obtained within 28 days prior to registrationXx_NEWLINE_xXCreatinine =< 2.0 x upper limit of normal (ULN) OR calculated (calc.) creatinine clearance >= 30 mL/minXx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN) OR calculated (calc.) creatinine clearance > 45 mL/min using the lean body mass formula onlyXx_NEWLINE_xXRe-registration: creatinine =< 1.5 ULN OR calc. creatinine clearance > 45 mL/min (using lean body mass formula only)Xx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) or serum creatinine clearance (CrCl) >= 40 ml/min, obtained within 4 weeks prior to randomizationXx_NEWLINE_xXSerum creatinine must be =< 2 x the institutional ULN OR creatinine clearance (either measured or calculated) must be > 30 mL/min; must be obtained within 28 days prior to registrationXx_NEWLINE_xXPatients must have creatinine clearance =< 2.5 x IULNXx_NEWLINE_xXSerum creatinine =< IULN OR measured or calculated creatinine clearance >= 60 mL/min, obtained within 28 days prior to step 2 registrationXx_NEWLINE_xXCreatinine =< upper limit of normal (ULN) or calculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXWithin 14 days of registration: Calculated (calc.) creatinine clearance > 50 mL/minXx_NEWLINE_xXPatients must have adequate renal function as documented by a calculated creatinine clearance >= 60 mL/min, within 28 days prior to registrationXx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN) mg/dL OR calculated (calc.) creatinine clearance >= 60 mL/minXx_NEWLINE_xXObtained within 28 days prior randomization: serum creatinine =< 1.5 x ULN for the lab or measured or calculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) or calculated creatinine clearance (CrCl) >= 40 mL/min, within 4 weeks of randomizationXx_NEWLINE_xXSerum creatinine =< 1.5 ULN OR measured or calculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXCreatinine clearance >= 45 ml/min documented within 28 days prior to step 1 registrationXx_NEWLINE_xXCalculated (calc.) creatinine clearance >= 50 mL/min\r\n* Estimated creatinine clearance for patients >= 18 years old will be estimated by the Jelliffe equation modified for body surface area (BSA); patients with creatinine clearance estimated > 70ml/min by this formula are eligible; if the creatinine clearance estimated by the Jelliffe method is >= 50 mL/min but =< 70 mL/min, then a second method to confirm a creatinine clearance of >= 50 mL/min is required; methods of estimating glomerular filtration rate (GFR) that can be used for this confirmation consist of a 12 or 24-hour urine creatinine clearance or a nuclear creatinine clearance test; if the confirmatory creatinine clearance is < 50 mL/min, then the patient is not eligible; if the confirmatory creatinine clearance is >= 50 mL/min, the patient is eligible; if the cause of the patient’s renal dysfunction is tumor obstructing the ureters, then eligibility can be determined by the study chair even if it does not meet these minimal requirements; for patients < 18 years old, it is strongly suggested that a radioisotope estimation of GFR be obtained; if a radioisotope test is not possible, an estimated creatinine clearance using either a 12 or 24 hour urine creatinine clearance or the Schwartz formula can be used; patients will be considered eligible if the creatinine clearance is > 70 mL/min; if the creatinine clearance estimated by the Schwartz formula or urine creatinine clearance is >= 50 mL/min but =< 70 mL/min, then a second method to confirm a creatinine clearance of >= 50 mL/min is required; methods of estimating GFR that can be used for this confirmation consist of a 12- or 24-hour urine creatinine clearance if the Schwartz formula or radioisotope method was used as the primary method or a radioisotope estimation of GFR if the Schwartz formula or urine creatinine clearance method was used as the primary method; if the confirmatory creatinine clearance is < 50 mL/min, then the patient is not eligible; if the confirmatory creatinine clearance is >= 50 mL/min, the patient is eligibleXx_NEWLINE_xXCreatinine =< 1.5 mg/dL OR creatinine clearance >= 45mL/minXx_NEWLINE_xXSerum creatinine clearance >= 30 ml/minXx_NEWLINE_xXObtained within 14 days prior to treatment start: Serum creatinine (CREAT) =< 1.5 mg/dL or creatinine clearance >= 50 mL/minXx_NEWLINE_xXCreatinine < 1.4 mg/dl and/or a measured creatinine clearance > 60 cc/minXx_NEWLINE_xXRenal: serum creatinine within normal limits (WNL), defined as within 25% of the institution's stated reference range, or a calculated creatinine clearance >45 mL/min/1.73 m. sq. for patients with abnormal, increased, creatinine levels.Xx_NEWLINE_xXSerum creatinine =< 1.5 x the upper limit of normal or calculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXCreatinine clearance >= 30 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 times ULN OR if serum creatinine >= 1.5 mg/dL, calculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXOr, if serum creatinine > 1.5 mg/dL: calculated creatinine clearance (ClCR) > 50 mL/minXx_NEWLINE_xXCreatinine < 1.5 mg/dL and calculated creatinine clearance >= 60 cc/minXx_NEWLINE_xXOr a calculated or measured creatinine clearance or radioisotope GFR >= 70ml/min/1.73m^2 obtained within 14 days prior to registrationXx_NEWLINE_xXCalculated creatinine clearance (Cr Cl) >= 50 ml/min; eligible for full dose methotrexateXx_NEWLINE_xXPatients ineligible for cisplatin based on any of the following criteria:\r\n* Estimated or calculated creatinine clearance >= 30ml/min but < 60 ml/min.\r\n* Grade 2 or above audiometric hearing loss (per CTCAE v4.0).\r\n* Grade 2 or above peripheral neuropathy (per CTCAE v4.0).Xx_NEWLINE_xXELIGIBILITY CRITERIA - PHASE I (ARMS A, B, C): Creatinine clearance of at least 50 mL/min within 7 days prior to first dose of study agentXx_NEWLINE_xXELIGIBILITY CRITERIA - PHASE II (ARM D): Creatinine clearance of at least 50 mL/min within 7 days prior to first dose of study agentXx_NEWLINE_xXSerum creatinine ? 1.5 x upper limit of normal (ULN) or calculated creatinine clearance ? 60 mL/minuteXx_NEWLINE_xXSerum creatinine ? 1.5 × upper limit of normal (ULN) or creatinine clearance (CrCl) ? 40 mL/min/1.73 m2Xx_NEWLINE_xXCreatinine > 1.5 times ULN concurrent with creatinine clearance < 50 ml/min; confirmation of creatinine clearance is only required when creatinine is > 1.5 times ULNXx_NEWLINE_xXCreatinine clearance (CrCl) >= 60 mL/minXx_NEWLINE_xXCalculated creatinine clearance at least 30 mL/min.Xx_NEWLINE_xXSerum creatinine > 1.5 x ULN and/or creatinine clearance ? 50 mL/minXx_NEWLINE_xXCreatinine =< 1.5 x the institutional upper limit of normal (ULN), or 24-hr clearance >= 50 mL/min, within 14 days of registrationXx_NEWLINE_xXCreatinine clearance < 40 mL/minXx_NEWLINE_xXCreatinine clearance > 50mL/minXx_NEWLINE_xXCalculated creatinine clearance (by Cockroft-Gault) >= 50 mL/min or serum creatinine below 2 g/dLXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or creatinine clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or estimated creatinine clearance >= 50 ml/minXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXSerum creatinine < 140 ?mol/L (< 1.6 mg/dL) or creatinine clearance > 60 mL/min.Xx_NEWLINE_xXChemistry Total bilirubin ? 2 mg/dL AST and/or ALT > 3 x ULN Serum creatinine > 1.5 x ULN and/or creatinine clearance ? 45 mL/minXx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal OR creatinine clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x institutional ULN or 24-hour clearance >= 50 mL/minXx_NEWLINE_xXCreatinine clearance =< 50 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL OR creatinine clearance >= 50 mL/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dl or a calculated creatinine clearance of > 60 ml/minXx_NEWLINE_xXPatients with severe renal impairment (creatinine clearance [CrCL] < 30 mL/min) are not eligible; a calculated CrCl is acceptableXx_NEWLINE_xXSerum creatinine >= 1.5 times the upper normal limit or calculated/measured creatinine clearance =< 60 mL/minXx_NEWLINE_xXCrCl ? 50 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5x ULN for age OR a creatinine clearance or radioisotope GFR >= 70ml/min/1.73 m^2Xx_NEWLINE_xXRenal: serum creatinine ?1.5 x ULN or creatinine clearance (CrCl) ?60 mL/min as calculated by the Cockroft-Gault methodXx_NEWLINE_xXCreatinine clearance > 60 Ml/min/1.73 m2 for patients with creatinine levels above ULN calculated using Calvert formulaXx_NEWLINE_xXCalculated creatinine clearance > 60 ml/min.Xx_NEWLINE_xXCreatinine =< 1.5 x ULN or creatinine clearance > 60 ml/minXx_NEWLINE_xXCalculated creatinine clearance > 50 mL/minXx_NEWLINE_xXPHASE II INCLUSION CRITERIA: Calculated creatinine clearance > 50 mL/minXx_NEWLINE_xXCreatinine clearance ? 40 mL/min (see Section 7.2.1 for instructions regarding calculation of creatinine clearance) performed within 28 days prior to randomization.Xx_NEWLINE_xXCreatinine clearance (CrCl) =< 40 mL/minXx_NEWLINE_xXAdequate renal function assessed by serum creatinine within reference lab normal limits and creatinine clearance (by Chronic Kidney Disease Epidemiology [CKD-EPI] Collaboration equation) ?60 mL/min.Xx_NEWLINE_xXObtained =< 21 days prior to registration: creatinine =< 2 mg/dL or creatinine clearance >= 40 mL/minXx_NEWLINE_xXSerum creatinine < 1.5 x upper limit of normal (ULN) or 24-hour creatinine clearance > 50 ml/minXx_NEWLINE_xXCreatinine clearance < 50 mL/min calculated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equationXx_NEWLINE_xXNormal creatinine for age or a calculated creatinine clearance >= 60 mL/min/1.73 m^2Xx_NEWLINE_xXEstimated creatinine clearance >= 60 mL/min as calculated using the method standard for the institutionXx_NEWLINE_xXCreatinine =< 1.5 x IULN OR creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x IULN (that is, if serum creatinine is > 1.5 x IULN, a 24-hour urine collection to calculate creatinine clearance must be performed)Xx_NEWLINE_xXSerum creatinine < 1.5 mg/dL or creatinine clearance >= 50 mL/minXx_NEWLINE_xXObtained =< 2 weeks prior to registration: Creatinine clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine < 2.0 x ULN or creatinine clearance > 30 cc/min performed within 30 days prior to the date of registrationXx_NEWLINE_xXSerum creatinine > 1.5 mg/dL. If serum creatinine > 1.5 mg/dL, the measured creatinine clearance must be measured and patient is eligible if creatinine clearance > 45 mL/min.Xx_NEWLINE_xXSerum creatinine < 1.5 mg/dL or creatinine clearance >= 50 mL/minXx_NEWLINE_xXCreatinine within the institution's laboratory upper limit of normal (ULN) or calculated creatinine clearance >50 ml/minXx_NEWLINE_xXCrCl (Creatinine Clearance) is >= 15 ml/min (<= 7 days prior to enrollment)Xx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine =< 1.5 mg/dL OR calculated (calc.) creatinine clearance >= 30 mL/minXx_NEWLINE_xXCalculated creatinine clearance >= 50 mL/minXx_NEWLINE_xXCalculated creatinine clearance by Modification of Diet in Renal Disease (MDRD) (CrCl) >= 60 ml/min/1.73 squared meterXx_NEWLINE_xXObtained =< 21 days prior to registration and confirmed prior to the first dose of study drug: Calculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXCreatinine clearance ? 50 mL/minXx_NEWLINE_xXObtained =< 35 days prior to registration: creatinine =< 1.5 mg/dL or creatinine clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine < 2.0 mg/dL or creatinine clearance >= 50 mL/minuteXx_NEWLINE_xXCreatinine clearance greater than or equal to (>=) 30 milliliters per minute (mL/min)Xx_NEWLINE_xXSerum creatinine ? 1.5 X ULN (OR creatinine clearance ? 60 mL/min/1.73 m2)Xx_NEWLINE_xXHave acceptable renal function defined as: Serum creatinine ? 1.5 × ULN, OR calculated creatinine clearance ? 45 mL/min for patients with creatinine levels above 1.5 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 x institution’s ULN, or creatinine clearance >= 30 ml/minXx_NEWLINE_xXSerum creatinine =< 2.5 mg/dL or a calculated creatinine clearance >= 50 mL/minXx_NEWLINE_xXCreatinine >1.5 times ULN concurrent with creatinine clearance <50 mL/minXx_NEWLINE_xXSerum creatinine > 1.5 x OR creatinine clearance of at least 40Xx_NEWLINE_xXSerum creatinine clearance >= 15 mL/min (performed within 14 days of treatment initiation)Xx_NEWLINE_xXPatient may not have severe renal disease (creatinine greater than 3 times normal for age OR creatinine clearance < 50 ml/m^2/1.73 m^2)Xx_NEWLINE_xXSerum creatinine ?1.5 × institutional upper limit of normal (ULN) or calculated creatinine clearance >30 mL/min.Xx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2Xx_NEWLINE_xXAdequate organ function within 14 days of study registration including:\r\n* Normal serum creatinine or creatinine clearance >= 60 ml/min/1.73 m^2Xx_NEWLINE_xXEstimated creatinine clearance >= 45 ml/minXx_NEWLINE_xXEither an estimated creatinine clearance value of > 50 mL/min as determined by the Chronic Kidney Disease Epidemiology (CKD EPI) or MDRD (Modification of Diet in Renal Disease) formulae or a creatinine clearance value of > 50 mL/min based on a 24 hour urine collectionXx_NEWLINE_xXSerum creatinine =< 2.0 x institution’s ULN or 24-hour creatinine clearance >= 50 ml/minXx_NEWLINE_xXCreatinine within 2 times normal institutional limits OR creatinine clearance >= 30 mL/min/1.73 m^2; Note, dose adjustments are required for creatinine clearance (CrCl) >= 30 mL/min but =< 60 ml/minXx_NEWLINE_xXCreatinine clearance ?60 mL/minXx_NEWLINE_xXCreatinine ? 1.5 x ULN or creatinine clearance (CrCl) ? 60 mL/minXx_NEWLINE_xXSerum creatinine < 2 mg/dL OR calculated creatinine clearance (CrCl) > 30 ml/minXx_NEWLINE_xXCalculated creatinine clearance >50 mL/min;Xx_NEWLINE_xXSerum creatinine >1.5 x ULN and/or measured creatinine clearance < 40 ml/minXx_NEWLINE_xXAdequate renal function as demonstrated by serum creatinine ? 1.5 x ULN or 24-hour urine creatinine clearance calculation ? 60 mL/min.Xx_NEWLINE_xXcreatinine ? 2.0 mg/dL, or calculated creatinine clearance ? 45 mL/minXx_NEWLINE_xXCreatinine (Cr) > 1.5 mg/dL or Cr clearance < 60 mL/m^2Xx_NEWLINE_xXEstimated creatinine clearance > 30 cc/min within four weeks of enrollmentXx_NEWLINE_xXEither creatinine < 1.5 x institutional upper limit of normal (ULN) or creatinine clearance > 60 mL/min as calculated by institution’s standard formulaXx_NEWLINE_xXSerum creatinine <= 1.5 mg/dL. (or estimated creatinine clearance >= 50 ml/min/1.73 m2)Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or estimated creatinine clearance >= 60 ml/min using Crockcroft-Gault estimationXx_NEWLINE_xXSerum creatinine < 1.4 mg/dL or calculated creatinine clearance (CrCl) >= 30 mL/minXx_NEWLINE_xXSerum creatinine =< 2 x upper limit of reference range or creatinine clearance >= 30 ml/minXx_NEWLINE_xXCreatinine =< 1.5 or creatinine clearance >= 60 ml/mlXx_NEWLINE_xXCreatinine < 2.0 mg/dL (for adults) or creatinine clearance > 60 ml/min (for children)Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL or creatinine clearance of > 40 ml/min within 45 days prior to initiation of therapy. (Patients with documented marrow involvement (with lymphoma) or hypersplenism secondary to involvement of the spleen by lymphoma at the time of randomization are not required to meet the parameter).Xx_NEWLINE_xXCreatinine clearance >= 40 mL/minXx_NEWLINE_xXRenal: Creatinine clearance (CrCl) > 50 ml/min (measured or calculated/estimated).Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or creatinine clearance >= 50 mL/minXx_NEWLINE_xXEstimated creatinine clearance must be > 40 mL/minXx_NEWLINE_xXSerum creatinine ?1.5x the ULN or creatinine clearance (CrCl) ?50 mL/min.Xx_NEWLINE_xXCreatinine clearance < 20 ml/minXx_NEWLINE_xXA pretreatment measured creatinine clearance (absolute value) of >= 60 ml/minuteXx_NEWLINE_xXCreatinine clearance (CrCl) < 30 ml/min/1.73m^2. Creatinine clearance is estimated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulaXx_NEWLINE_xXCalculated or measured creatinine clearance >= 30 ml/min, obtained =< 14 days prior to registrationXx_NEWLINE_xXCreatinine clearance > 30 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or 24-hour creatinine clearance >= 50 ml/minXx_NEWLINE_xXCreatinine clearance >= 30 mL/minXx_NEWLINE_xXSerum creatinine < 2.0 mg/dL OR creatinine clearance (Cockcroft) >= 40 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine clearance >= 15 ml/minXx_NEWLINE_xXCreatinine less than 1. 5 X ULN and/or creatinine clearance >= 60 mL/minXx_NEWLINE_xXCalculated creatinine clearance >= 60 ml/min.Xx_NEWLINE_xXMeasured creatinine clearance >45 mL/minute (as assessed with a 24-hour urine collection)Xx_NEWLINE_xXCreatinine: Creatinine clearance > 25 ml/minXx_NEWLINE_xXCreatinine < 1.5 x ULN OR creatinine clearance > 50 mL/min for subject with creatinine levels > 1.5 x ULNXx_NEWLINE_xXSerum creatinine =< IULN OR measured or calculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXSerum Creatinine or Creatinine Clearance** ? 1.5 x ULN, > 50 mL/minXx_NEWLINE_xXCOHORT 1: HORMONE RECEPTOR POSITIVE BREAST CANCER: Serum creatinine =< 1.5 X upper limit of normal (ULN), or measured creatinine clearance >= 60 mL/min/1Xx_NEWLINE_xXCOHORT 2: TRIPLE NEGATIVE BREAST CANCER: Serum creatinine =< 1.5 X upper limit of normal (ULN), or measured creatinine clearance >= 60 mL/min/1Xx_NEWLINE_xXCOHORT 3: ENDOMETRIAL CANCER: Serum creatinine =< 1.5 X upper limit of normal (ULN), or measured creatinine clearance >= 60 mL/min/1Xx_NEWLINE_xXCreatinine clearance 30-75 mL/minXx_NEWLINE_xXCreatinine clearance ? 50 mL/minXx_NEWLINE_xXCreatinine clearance > 50 ml/minXx_NEWLINE_xXRenal: Creatinine clearance of ? 40 mL/min, estimated or calculated.Xx_NEWLINE_xXCreatinine clearance >= 50 mL/minXx_NEWLINE_xXCreatinine clearance ? 45ml/minXx_NEWLINE_xXCreatinine =< 1.5 mg/dL OR creatinine clearance >= 45 mL/minXx_NEWLINE_xXCalculated creatinine clearance of >= 50 mL/minXx_NEWLINE_xXCreatinine clearance of >= 50 mL/minXx_NEWLINE_xXSerum creatinine ? 1.5 mg/dl OR calculated creatinine clearance ? 50 for those patients with creatinine greater than 1.5 obtained ? 14 days prior to randomizationXx_NEWLINE_xXCreatinine clearance >= 50 cc/minXx_NEWLINE_xXCreatinine clearance < 30 ml/minXx_NEWLINE_xXSerum creatinine =< 2 mg/dL or calculated creatinine clearance of >= 40 ml/min within 14 days of registration using Modification of Diet in Renal Disease (MDRD) formulaXx_NEWLINE_xXCreatinine clearance >= 30 ml/minXx_NEWLINE_xXWithin 3 days before the first dose of study drug: creatinine clearance > 50 mL/minXx_NEWLINE_xXCreatinine =< 1.5 x ULN or calculated creatinine clearance >= 60 mL/min for subject with creatinine ? 1.5 x institutional ULN obtained =< 14 days prior to registrationXx_NEWLINE_xXSerum creatinine (Cr) =< 1.5 X ULN or creatinine clearance (CrCl) >= 50 ml/minXx_NEWLINE_xXEither creatinine > 2.0 mg/dL or creatinine clearance < 30 mL/minXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dl and/or creatinine clearance of > 40 ml/min (excludes multiple myeloma patients receiving high dose melphalan conditioning)Xx_NEWLINE_xXWithin 4 weeks before enrollment: Calculated creatinine clearance > 40 mL/minXx_NEWLINE_xXSerum creatinine =< 2 mg/dL OR creatinine clearance > 50 mL/min.Xx_NEWLINE_xXSerum creatinine < 2 x upper limit of normal (ULN) or estimated creatinine clearance > 30 ml/min as calculated using the method standard for the institutionXx_NEWLINE_xXCalculated creatinine clearance >= 10 mL/minXx_NEWLINE_xXCreatinine clearance >= 50 mL/min.Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL OR creatinine clearance >= 50 mL/min/1.73 m^2.Xx_NEWLINE_xXSerum creatinine < 2.5 mg/dL or creatinine clearance > 30 cc/minXx_NEWLINE_xXSubjects with severe renal impairment (i.e., creatinine clearance =< 30 mL/min)Xx_NEWLINE_xXCreatinine =< 2.0 mg/dL or calculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXSerum creatinine clearance or radioisotope GFR ?50 milliliters/minute/1.73 m^2, based on a 12 or 24 hours (h) urine creatinine collection.Xx_NEWLINE_xXCreatinine clearance >= 40 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine =< 1.5 ULN or calculated creatinine clearance >= 50 ml/minXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above 2 mg/dL (unless dysfunction is secondary to lymphoma involvement); creatinine clearance (Cr Cl) will be calculated with the use of the 24-hour creatinine clearance or modified Cockcroft-Gault equationXx_NEWLINE_xXWithin 14 days of the first dose of study drug: Serum creatinine =< 1.5 times the upper limit of normal or estimated creatinine clearance (CrCL) > 40 mL/minXx_NEWLINE_xXFor Arm G, subjects must have an estimated creatinine clearance >= 50 ml/min.Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL OR creatinine clearance >= 50 mL/min/1.73 m^2, at the time of enrollmentXx_NEWLINE_xXEither serum creatinine > 1.7 mg/dL, or creatinine clearance < 50 mL/min calculated by the Cockcroft Gault method, eventually confirmed by measured creatinine clearance (or measured glomerular filtration rate [GFR] using plasma clearance methods)Xx_NEWLINE_xXObtained =< 28 days prior to registration: Creatinine =< 1.0 x ULN OR measured or calculated creatinine clearance (per institutional standard) must be >= 60 ml/minXx_NEWLINE_xXSerum creatinine clearance >= 30 mL/minXx_NEWLINE_xXCreatinine =< 2.0 x the institutional upper limit of normal (ULN) OR creatinine clearance > 30 ml/min within 14 days of cycle 1 day 1Xx_NEWLINE_xXCreatinine levels < 2 mg/dL; or creatinine clearance > 40 mL/minXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 unless reduced creatinine clearance felt by investigator to be acute and reversibleXx_NEWLINE_xXSerum creatinine clearance of >= 50 ml/min (calculated or measured)Xx_NEWLINE_xXSerum creatinine less than or equal to 1.5 mg/dl unless the measured creatinine clearance is greater than 60 mL/min/1.73 m^2Xx_NEWLINE_xXPretreatment calculated or measured creatinine clearance (absolute value) of >= 60 mL/minute.Xx_NEWLINE_xXCreatinine > or = 2.0 x ULN or creatinine clearance < 50 mL/min (calculated).Xx_NEWLINE_xXMeasured creatinine clearance > 60 mls/minXx_NEWLINE_xXObtained within 14 days prior to enrollment: calculated creatinine clearance > 30 ml/minXx_NEWLINE_xXCreatinine clearance < 30 ml/minXx_NEWLINE_xXCreatinine clearance >= 50 ml/minXx_NEWLINE_xXSerum creatinine clearance >= 30 mL/minXx_NEWLINE_xXRenal: Serum creatinine 1.5 x ULN or creatinine clearance 60 mL/min.Xx_NEWLINE_xXSerum creatinine =< 2 x upper limit of normal (ULN) or estimated creatinine clearance >= 15 mL/min as calculated using the method standard for the institutionXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2 by Cockcoft-GaultXx_NEWLINE_xXCreatinine =< 2.0 mg/100 mlXx_NEWLINE_xXSerum creatinine =< 1.5 x institution’s upper limit of normal (ULN), or creatinine clearance >= 60 ml/minXx_NEWLINE_xXPatients must have a calculated creatinine clearance of >= 35Xx_NEWLINE_xXCalculated or measured creatinine clearance >= 50 ml/minXx_NEWLINE_xXCreatinine clearance ? 50 ml/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or 24-hour clearance >= 50 mL/minXx_NEWLINE_xXCreatinine =< 1.5 x ULN OR creatinine clearance >= 50 mL/min/1.73 m^2Xx_NEWLINE_xXCabazitaxel: Creatinine clearance >= 30 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine =< 1.5 x ULN or calculated creatinine clearance >= 60 mL/min for subject with creatinine ? 1.5 x institutional ULN obtained =< 14 days prior to registrationXx_NEWLINE_xXCreatinine clearance of >= 60 ml/minXx_NEWLINE_xXCreatinine clearance >= 15 mL/minXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dl or creatinine clearance > 60 ml/min within 30 days of enrollment to studyXx_NEWLINE_xXCreatinine OR =< 1.5 x ULN; calculated creatinine clearance OR >= 50 mL/min; 24-hour urine creatinine clearance >= 50 mL/minXx_NEWLINE_xXCreatinine =< 2.0 mg/dL; however, patients with a creatinine > 2.0 mg/dL but with a calculated creatinine clearance of > 30 ml/min, as measured by the Modification of Diet in Renal Disease (MDRD) equation, will be eligibleXx_NEWLINE_xXSerum creatinine =< 1.8 mg/dL or creatinine clearance > 50 mL/minXx_NEWLINE_xXEstimated creatinine clearance >=60mL/min/1.73 square meter (m^2)Xx_NEWLINE_xXSerum creatinine ? 2.0 x ULN or calculated creatinine clearance ? 45 mL/min based on the Cockroft-Gault GFR estimation. For newly diagnosed AML patients < 75 years of age, creatinine clearance ? 30 mL/min; for ? 75 years of age, creatinine clearance ? 45 mL/min.Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL, or if creatinine > 1.5 mg/dL, calculated creatinine clearance of >= 50 mL/min by 24 hour creatinine clearance or Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or a calculated creatinine clearance >= 60 ml/min/1.73 m^2 (Cockcroft-Gault method) for patients receiving combination of cisplatin and pemetrexed and >= 45 ml/min/1.73 m^2 for patients receiving pemetrexed; 24 hour urine for creatinine clearance is acceptable if the calculated creatinine clearance is insufficientXx_NEWLINE_xXAdequate renal function, as defined by estimated serum creatinine clearance >= 60 ml/min and a normal serum creatinine for ageXx_NEWLINE_xXCreatinine level =< upper limit of normal (ULN): if creatinine > ULN, creatinine clearance must be > 60 ml/minXx_NEWLINE_xXObtained =< 14 days prior to registration: Calculated or measured creatinine clearance >= 30 ml/minXx_NEWLINE_xXObtained =< 7 days prior to registration: Serum creatinine =< 2 x ULN or 24 hour creatinine (Cr) clearance > 60 ml/minXx_NEWLINE_xXCalculated creatinine clearance must be >= 30 mL/minuteXx_NEWLINE_xXSerum creatinine =< 1.5 x laboratory upper limit of normal or calculated creatinine clearance of >= 50 ml/min/1.73 m^2)Xx_NEWLINE_xXCreatinine =< 2.0 mg/dL (adults) and creatinine clearance > 40 mL/min (pediatrics); adults with a creatinine > 1.2 or a history of renal dysfunction must have estimated creatinine clearance > 40 ml/min/1.73m^2Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or creatinine clearance (CrCl) >= 40 mL/minXx_NEWLINE_xXEstimated creatinine clearance > 45 ml/minXx_NEWLINE_xXAdequate renal function defined as: • Serum creatinine ? 1.5 x ULN (upper normal limit) or calculated creatinine clearance (determined by MDRD) > 50 mL/min/1.73m2.Xx_NEWLINE_xXSerum creatinine =< 1.5 x institutional ULN or 24-hour clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine =< upper limit of normal (ULN) for the lab or a calculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXCreatinine >1.5 times ULN or creatinine clearance <50 mL/min (measured or calculated by Chronic Kidney Disease Epidemiology (CKD-EPI) Collaboration equation); confirmation of creatinine clearance is only required when creatinine is >1.5 times ULN.Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN, or 24-hr clearance >= 60 ml/min, within 14 days start of study startXx_NEWLINE_xXEstimated creatinine clearance > 40 mL/min (this must be checked twice before initiating therapy)Xx_NEWLINE_xXCreatinine less than or equal to 1.5 x upper limit of normal (ULN) with calculated creatinine clearance greater than 30 ml/minXx_NEWLINE_xXSerum creatinine <1.5 mg/dl or creatinine clearance?50 mL/minXx_NEWLINE_xXCreatinine clearance < 30 mL/minXx_NEWLINE_xXSerum creatinine > 1.5 x ULN for age or creatinine clearance =< 60 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine clearance > 25 ml/minXx_NEWLINE_xXPatients must have creatinine of less than or equal to 1.5 mg/dL or creatinine clearance > 60 ml/minXx_NEWLINE_xXCreatinine clearance >= 40 ml/min (24 hour urine collection preferred; can be calculated if not available)Xx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine clearance >= 40 mL/min (measured or calculated per local practice)Xx_NEWLINE_xXEstimated or measured creatinine clearance > 50 mL/minXx_NEWLINE_xXCreatinine clearance (calculated creatinine clearance by Cockroft-Gault using adjusted body weight if actual body weight is 20% greater than ideal is permitted) should be > 50 ml/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or creatinine clearance >= 60 mL/minXx_NEWLINE_xXCreatinine clearance (CrCl) must be > 20 mL/minXx_NEWLINE_xXCalculated creatinine clearance (CrCl) > 30 mL/minXx_NEWLINE_xXCreatinine clearance greater than 30 ml/minXx_NEWLINE_xXCalculated or measured creatinine clearance (method determined by the prescribing physicians) < 50 ml/minXx_NEWLINE_xXCreatinine clearance >= 40 mL/min, estimated or calculatedXx_NEWLINE_xXSerum creatinine < 2.0 times the upper limit of normal (ULN) (or a calculated creatinine clearance >= 60 mL/min)Xx_NEWLINE_xXSerum creatinine clearance >= 30 ml/minXx_NEWLINE_xXCalculated or measured creatinine clearance (CrCl) > 30 ml/minXx_NEWLINE_xXCreatinine clearance >= 40 ml/min or serum creatinine =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXCreatinine =< 2.0 mg/dl (adults) and creatinine clearance >= 40 mL/min (pediatrics); adults with a creatinine > 1.2 mg/dl or a history of renal dysfunction must have estimated creatinine clearance >= 40 ml/min/1.73m^2Xx_NEWLINE_xXAdequate kidney function with serum creatinine <2 x the ULN or creatinine clearance >30 mL/minXx_NEWLINE_xXSerum creatinine ? 1.5 x ULN or estimated creatinine clearance ? 60 mL/minXx_NEWLINE_xXCreatinine clearance >= to 50 ml/minXx_NEWLINE_xXCalculated creatinine clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine =< 2 x ULN or 24 hour creatinine (Cr) clearance > 30 ml/min obtained =< 7 days prior to registrationXx_NEWLINE_xXAdequate renal function as demonstrated by a serum creatinine ?1.5 mg/dL or a creatinine clearance >60 mL/min;Xx_NEWLINE_xXCreatinine =< 1.5 x the upper limit of normal (ULN) OR \r\n* Estimated creatinine clearance of > 50 ml/min\r\n* Patients with renal dysfunction deemed to be the result of disease will be considered eligibleXx_NEWLINE_xXSerum creatinine less than or equal to 1.3 mg/dL and/or creatinine clearance > 40 mL/minXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73m^2 for patients with creatinine >= 1.5 x upper limit of normalXx_NEWLINE_xXDONOR: Serum creatinine within normal limits or a minimum creatinine clearance (CrCl) value of >= 60 ml/min calculated using the Modification of Diet in Renal Disease (MDRD) study equationXx_NEWLINE_xXSerum creatinine =< 1.5 x the upper limit of normal or calculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x the ULN and calculated creatinine clearance > 30 ml/minXx_NEWLINE_xXEstimated creatinine clearance >= 30 mL/min (calculated or measured by 24 hour urine collection)Xx_NEWLINE_xXCalculated creatinine clearance >= 45 mL/minXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 X ULN (OR creatinine clearance >= 60 mL/min/1.73 m^2)Xx_NEWLINE_xXCalculated creatinine clearance >= 50 mL/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or creatinine clearance >= 50 mL/minXx_NEWLINE_xXEstimated serum creatinine clearance >= 50 ml/min (Modification of Diet in Renal Disease [MDRD] method) and/or serum creatinine =< 1.8 mg/dLXx_NEWLINE_xXCAPMATINIB INCLUSION CRITERIA: Creatinine OR creatinine clearance within normal limits > 40 mL/min (calculated by Cockgraft-Gault) for patients with creatinine levels above ULNXx_NEWLINE_xXCERITINIB INCLUSION CRITERIA: Creatinine OR creatinine clearance < 1.5 mg/dL >= 30 mL/min (calculated by Cockgraft-Gault) for patients with creatinine levels above ULNXx_NEWLINE_xXREGORAFENIB INCLUSION CRITERIA: Creatinine OR creatinine clearance =< 1.5 x ULN; > 40 mL/min (calculated by Cockgraft-Gault) for patients with creatinine levels above ULNXx_NEWLINE_xXENTRECTINIB INCLUSION CRITERIA: Creatinine OR creatinine clearance within normal limits; > 40 mL/min (calculated by Cockgraft-Gault) for patients with creatinine levels above ULNXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL and/or calculated creatinine clearance >= 50 mL/min (via Cockroft and Gault)Xx_NEWLINE_xXCreatinine clearance < 30 ml/min which cannot be attributed to MCC metastasisXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or creatinine clearance (CrCl) >= 40 mL/minXx_NEWLINE_xXCreatinine clearance of >= 60 mL/minXx_NEWLINE_xXEstimated creatinine clearance less than 50 ml/minuteXx_NEWLINE_xXSerum creatinine =< 2.5 or estimated creatinine clearance >= 30 ml/min and not dialysis-dependentXx_NEWLINE_xXSerum creatinine =< 1.25 times upper limit of normal or calculated creatinine clearance >= 50 ml/minXx_NEWLINE_xXCreatinine clearance (measured via 24-hour urine collection) >= 40 mL/minute (that is, if serum creatinine is > 1.5 times the ULN, a 24-hour urine collection to calculate creatinine clearance must be performedXx_NEWLINE_xXEither a serum creatinine ? ULN for age, or calculated or measured GFR ? 70 mL/min/1.73 m2Xx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXSerum creatinine =< 1.8 mg/dL and/or estimated serum creatinine clearance >= 50 ml/minXx_NEWLINE_xXCreatinine =< 1.5 mg/dL or creatinine clearance >= 60 ml/minXx_NEWLINE_xXSerum creatinine > 1.5 x upper limit of normal (ULN) and calculated creatinine clearance, based on a 24-hour urine collection, < 30 mL/min--unless related to ALL/tumor lysis syndrome and able to be correctedXx_NEWLINE_xXPHASE II COLORECTAL CANCER COHORT 6 (MEDI+C ONLY):\r\nCreatinine =< 1.5 X within normal institutional limits OR measured creatinine clearance >= 50 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN) for the laboratory or calculated or actual creatinine clearance >= 60 mL/minXx_NEWLINE_xXRenal: Serum/plasma creatinine (sCr) ?1.5 x upper limit of normal, or creatinine clearance (Ccr) ?50 mL/min.Xx_NEWLINE_xXCreatinine clearance >= 30 ml/minuteXx_NEWLINE_xXA pretreatment measured creatinine clearance (absolute value) of >= 50 ml/minuteXx_NEWLINE_xXCreatinine (Cr) clearance >= 30 mL/minXx_NEWLINE_xXCreatinine clearance >= 45 mL/minXx_NEWLINE_xXCreatinine > 2 mg/dL and an estimated creatinine clearance =< 40 mL/minXx_NEWLINE_xXEstimated creatinine clearance must be > 40 mL/minXx_NEWLINE_xXCreatinine clearance of < 50 ml/minXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/min or serum creatinine =< 1.5 mg/dlXx_NEWLINE_xXEstimated creatinine clearance < 15 mL/minXx_NEWLINE_xXCalculated creatinine clearance (by Cockroft-Gault) >= 50 ml/min or serum creatinine below 2 g/dLXx_NEWLINE_xXCalculated creatinine clearance ? 30 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal OR creatinine clearance on a 24-hour (h) urine collection of >= 60 mL/minXx_NEWLINE_xXCreatinine less than 1.5 x ULN, or a 24 hour creatinine clearance of 60 mg/mL or moreXx_NEWLINE_xXCreatinine clearance or radioisotope GFR ? 70ml/min/1.73 m² OR age/gender appropriate serum creatinine.Xx_NEWLINE_xXSerum creatinine of < 1.5 mg/dL, and a measured creatinine clearance of > 60 mL/minXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXCreatinine clearance >= 30 mL/minutesXx_NEWLINE_xXSerum creatinine =<1.5 mg/dL or creatinine clearance > 50 ml/min; some patients with minor deviations may be accepted on protocol after discussion with the PIXx_NEWLINE_xXCreatinine clearance of >= 50Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN OR a measured creatinine clearance or calculated creatinine clearance >= 50 mL/minXx_NEWLINE_xX24-hour urine creatinine clearance >= 50 mL/min, obtained within 30 days of study registrationXx_NEWLINE_xXCreatinine clearance > 50 ml/min (calculated creatinine clearance is permitted)Xx_NEWLINE_xXCreatinine =< 1.5 x ULN 2 OR calculated creatinine clearance >= 50 mL/min OR 24-hour urine creatinine clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine < 1.5 mg/dl or creatinine clearance (CrCl) > 60 mL/min, performed within 28 days prior to registrationXx_NEWLINE_xXSerum creatinine =< 1.5 times the upper limit of normal or estimated creatinine clearance (CrCl) > 40 mL/min within 14 days of the first dose of study drugXx_NEWLINE_xXCreatinine clearance (Clcr) > 25 mL/minXx_NEWLINE_xXCreatinine clearance < 30 ml/minXx_NEWLINE_xXCalculated creatinine clearance (absolute value) of >= 50 mL/minute or creatinine < 2.0 mg/dl or < 2 times upper limit of normal for the research participant's age groupXx_NEWLINE_xXEstimated creatinine clearance >= 50 mL/minXx_NEWLINE_xXWithin 30 days of first vaccination: Serum creatinine =< 1.2 mg/dl or creatinine clearance > 60 ml/minXx_NEWLINE_xXIf the research participant is to undergo leukapheresis, he/she must have a pretreatment calculated creatinine clearance of >= 50 mL/minuteXx_NEWLINE_xXCreatinine clearance >= 30 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine clearance < 50 mL/min/1.73m^2Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or 24-hour clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine ? 2.5 mg/dL or calculated creatinine clearance (CrCl) ?25.0 mL/min.Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or a measured creatinine clearance >= 50 mL/min (to be performed within 7 days prior to start of study treatment)Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL OR creatinine clearance >= 50 mL/min/1.73 m^2Xx_NEWLINE_xXMeasured creatinine clearance >= 40 ml/min per 24 hour urine collection OR serum creatinine =< 1.3 mg/dLXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or 24-hour clearance >= 50 ml/minXx_NEWLINE_xXEstimated creatinine clearance at least 50 ml/minXx_NEWLINE_xXSerum creatinine < 1.5 times upper limit of normal range (ULN) or creatinine clearance >= 40 ml/minXx_NEWLINE_xXCreatinine clearance > 50 ml/min/1.73 m^2 (Schwartz formula)Xx_NEWLINE_xXCreatinine < 1.5 x the upper limit of normal (ULN) or calculated creatinine clearance of >= 50ml/minXx_NEWLINE_xXSerum creatinine =< 1.5mg/dl OR calculated creatinine clearance >= 50 for those patients with creatinine greater than 1.5Xx_NEWLINE_xXSerum creatinine within normal range with a creatinine clearance >= 30 ml/minXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal OR creatinine clearance on a 24-h urine collection of >= 60 mL/minXx_NEWLINE_xXRelapsed/refractory MCL: Creatinine (Cr) clearance >= 30 mL/minXx_NEWLINE_xXNewly diagnosed MCL: Creatinine (Cr) Clearance >= 30 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x the upper limit of normal or calculated creatinine clearance >= 60 ml/minXx_NEWLINE_xXRECIPIENT: Creatinine: adult patients: =< 2.0 mg/dl and creatinine clearance >= 30 ml/min; pediatric patients (< 18 years old) creatinine < 1.5 mg/dL and a creatinine clearance > 30 mL/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or 24-hour clearance >= 50 ml/minXx_NEWLINE_xXCreatinine clearance (CrCl) > 45 mL/minXx_NEWLINE_xXCreatinine clearance >= 50 ml/min/1.73m^2Xx_NEWLINE_xXSevere renal insufficiency (estimated creatinine clearance <20 mL/min) or on hemodialysis at the time of randomization or likely to require dialysis during the study.Xx_NEWLINE_xXCreatinine clearance of >= 60 mL/minXx_NEWLINE_xXCreatinine clearance equal to or more than 50 mL/minXx_NEWLINE_xXSerum creatinine < 1.5 mg/dL OR creatinine clearance > 60 mL/minXx_NEWLINE_xXCalculated or measured creatinine clearance >= 60 cc/min for cisplatin candidates, >= 30 cc/min for carboplatin candidatesXx_NEWLINE_xXCreatinine serum =< 2.0 mg/dl or creatinine clearance >= 45 mL/min\r\n* If calculated creatinine clearance is < 45 mL/min, a 24-hour urine collection for creatinine clearance may be performedXx_NEWLINE_xXSerum creatinine =< 1.2 mg/dl or if serum creatinine is outside the normal range, then creatinine clearance (CrCl) > 40 ml/min (measured or calculated/estimated)Xx_NEWLINE_xXCalculated creatinine clearance > 30 ml/minXx_NEWLINE_xXOr, if > 1.5 mg/dL: calculated creatinine clearance (ClCR) >= 30 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) or creatinine clearance > 50 mL/minXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dl or creatinine clearance >= 60 mL/minXx_NEWLINE_xXEstimated or measured creatinine clearance >= 45 mL/minuteXx_NEWLINE_xXSerum creatinine of =< 1.5 mg/dL, and a measured creatinine clearance of >= 60 mL/minXx_NEWLINE_xXPatients must have a serum creatinine clearance >= 40 mL/min (as per the Jelliffe method) or by 12-hour or 24-hour urine creatinine clearanceXx_NEWLINE_xXCreatinine < 1.7mg/dL or creatinine clearance >= 60 cc/min (performed within 14 days prior to registration)Xx_NEWLINE_xXCalculated creatinine clearance >= 40 ml/min or 24 hour urineXx_NEWLINE_xXCalculated creatinine clearance >= 45 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine =< 1.5 mg/dL or creatinine clearance >= 40 mL/min\r\n* If serum creatinine is > 1.5 times the upper limit of normal (ULN), a 24-hour urine collection to calculate creatinine clearance must be performedXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or clearance >= 60 mL/min (measured or calculated)Xx_NEWLINE_xXCreatinine clearance of >= 60 mL/minXx_NEWLINE_xXCreatinine < 1.5 mg/dL or calculated creatinine clearance > 60 mL/minXx_NEWLINE_xXCreatinine must also be < 1.8 mg/dl or a creatinine clearance > 50 ml/minXx_NEWLINE_xXCreatinine clearance of >= 60 ml/minXx_NEWLINE_xXCreatinine clearance > 60 ml/minXx_NEWLINE_xXCreatinine: \r\n* Patients: =< 2.0 mg/dl or creatinine clearance >= 30 ml/min/1.73 m^2\r\n* Pediatric patients (< 18 years old): creatinine =< 1.5 mg/dl or a creatinine clearance of >= 30 mL/min/1.73 m^2Xx_NEWLINE_xXPatients with renal insufficiency or creatinine (cr) clearance < 60 ml/minXx_NEWLINE_xXSerum creatinine =< 1.2 mg/dL or if serum creatinine is outside the normal range, then creatinine clearance (CrCl) > 40 ml/min (measured or calculated/estimated)Xx_NEWLINE_xXCreatinine =< 1.5 or creatinine clearance >= 60 ml/minXx_NEWLINE_xXEstimated serum creatinine clearance >= 50 ml/min and/or serum creatinine =< 1.8 mg/dLXx_NEWLINE_xXAdequate renal function (creatinine =< 1.25 upper limit of institutional normal [ULIN] or calculated creatinine clearance > 50 ml/min)Xx_NEWLINE_xXEstimated creatinine clearance >= 50 ml/minXx_NEWLINE_xXSerum creatinine =< 2 x the institutional ULN and measured or estimated creatinine clearance > 60 cc/minXx_NEWLINE_xXAdequate renal function defined as creatinine =< 2.0 mg/dl (adults) or estimated creatinine clearance > 40 ml/min (pediatrics); all adults with a creatinine > 1.2 or a history of renal dysfunction must have estimated creatinine clearance > 40 ml/minXx_NEWLINE_xXCalculated creatinine clearance > 60 ml/minXx_NEWLINE_xXAdequate renal function defined as creatinine =< 2.0 mg/dl (adults) or creatinine clearance > 40 ml/min (pediatrics)Xx_NEWLINE_xXAll adults with a creatinine > 1.2 or a history of renal dysfunction must have estimated creatinine clearance > 40 ml/minXx_NEWLINE_xXPer MDACC Creatinine clearance guidelines, patients must have a Creatinine clearance > 50 ml/min determined by 24 hour collection or nomogram: CrCl male = (140 - age) x (wt in kg)/serum Cr x 72 CrCl female = 0.85 x (CrCl male)Xx_NEWLINE_xXThe patient must have a corrected creatinine clearance >= 50% of normalXx_NEWLINE_xXCreatine clearance >= 40 ml/minXx_NEWLINE_xXCreatinine =< 2.0 mg/100 mlXx_NEWLINE_xXCreatinine =< 2.0 mg/dl or creatinine clearance > 50 ml/minXx_NEWLINE_xXCreatinine =< 2.0 mg/dl or creatinine clearance > 50 ml/minXx_NEWLINE_xXPatients with severe renal disease (i.e., creatinine clearance less than 40 cc/1.73 m^2)Xx_NEWLINE_xXCreatinine < 2.0 (adults) or creatinine clearance > 40 ml/min (pediatrics)Xx_NEWLINE_xXRenal: creatinine =< 2.0 mg/dl (adults) and creatinine clearance > 40 ml/min (pediatrics); adults with a creatinine > 1.2 or a history of renal dysfunction must have estimated creatinine clearance > 40 ml/minXx_NEWLINE_xXCreatinine =< 1.5 mg/dl or creatinine clearance >= 50 ml/minXx_NEWLINE_xXPatients with significant renal (creatinine [Cr.] > 1.5 mg/dl or creatinine clearance < 40 cc/min) or hepatic (bilirubin > 2.5 u) dysfunction not due to tumor involvement will not be eligible to receive DA-EPOCH-R chemotherapyXx_NEWLINE_xXOr creatinine clearance or radioisotope GFR ?50 milliliters per minute (mL/min)/1.73 meters squared (m^2) based on a 12 or 24 hour urine creatinine collectionXx_NEWLINE_xXCalculated creatinine clearance ?50 mL/min.Xx_NEWLINE_xXCreatinine =< 2.0 mg/dl (adults) and creatinine clearance >= 40 mL/min (pediatrics); adults with a creatinine > 1.2 mg/dl or a history of renal dysfunction must have estimated creatinine clearance >= 40 ml/min/1.73 m^2Xx_NEWLINE_xXCalculated creatinine clearance of ? 50 ml/min.Xx_NEWLINE_xXCalculated Creatinine Clearance of 50 ml/minXx_NEWLINE_xXCreatinine clearance >= 50 mL/min (repeat if more than 3 days before the first dose)Xx_NEWLINE_xXCalculated creatinine clearance > 50 mL/min.Xx_NEWLINE_xXCreatinine < (1.5 mg/dL) during screening evaluation (> 1.5 is allowed if EGFR > 45 mL/min/1.73 m^2)Xx_NEWLINE_xXSerum creatinine ? 2 mg/dL and creatinine clearance ? 60 ml/hrXx_NEWLINE_xXSerum creatinine ? 2 mg/dL and creatinine clearance ? 40 ml/hrXx_NEWLINE_xXSerum creatinine ? 1.5 x Upper Limit of Normal or creatinine clearance ? 40 mL/min (if using the Cockcroft-Gault formula below): Female Creatinine Clearance = [(140 - age in years) x weight in kg x 0.85] / [72 x serum creatinine in mg/dL] Male Creatinine Clearance = [(140 - age in years) x weight in kg x 1.00] / [72 x serum creatinine in mg/dL]Xx_NEWLINE_xXCreatinine clearance ? 45 cc/minXx_NEWLINE_xXCalculated creatinine clearance >30ml/mXx_NEWLINE_xXCalculated creatinine clearance of <60 mL/min in Stage 1 and <40 mL/min in Stage 2Xx_NEWLINE_xXSerum creatinine > 2.0 mg/dL or creatinine clearance of < 30 mL/minXx_NEWLINE_xXPatients with moderate or severe renal impairment (calculated creatinine clearance of < 60 mL/min)Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or 24-hour clearance >= 50 mL/minXx_NEWLINE_xXAdequate renal function documented by serum creatinine of 1.5 mg/dl or less, or calculated creatinine clearance > 50 ml/min.Xx_NEWLINE_xXAdequate renal function defined by a creatinine clearance of ?30 mL/minXx_NEWLINE_xXCreatinine ?1.5 times the upper limit of normal (ULN) and/or creatinine clearance ?60 mL/minXx_NEWLINE_xXCreatinine clearance ? 30 mL/minXx_NEWLINE_xXStable creatinine =< 2.0 mg/dL or creatinine clearance >= 60 ml/min performed within 60 days of enrollmentXx_NEWLINE_xXCreatinine <2.0 mg/dL or creatinine clearance ?50 mL/minXx_NEWLINE_xXSerum creatinine > 1.5 x upper limit of normal or estimated creatinine clearance (CrCl) < 45 ml/minXx_NEWLINE_xXORAL CAVITY SQUAMOUS CELL CARCINOMA COHORT: Calculated creatinine clearance > 50 mL/minXx_NEWLINE_xXHPV-ASSOCIATED OROPHARYNX SQUAMOUS CELL CARCINOMA: Calculated creatinine clearance > 50 mL/minXx_NEWLINE_xXCreatinine clearance > 40 ml/min (calculated or measured)Xx_NEWLINE_xXCreatinine =< 1.5 x IULN OR measured or calculated creatinine clearance >= 50 mL/min for patients with creatinine levels > 1.5 x IULNXx_NEWLINE_xXSerum creatinine within 1.5 x normal range for age OR creatinine clearance with a recommended eGFR ? 50 mL/min/1.73m^2Xx_NEWLINE_xXSerum creatinine within 1.5 x normal range for age OR creatinine clearance with a recommended eGFR ? 50 mL/min/1.73m^2Xx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXSerum creatinine ? 1.5 x ULN, or 24-hour (hr) clearance ? 60 ml/minXx_NEWLINE_xXEstimated creatinine clearance >= 60 ml/min as calculated using the method standard for the institutionXx_NEWLINE_xXCalculated creatinine clearance of > 60 mL/min/m^2, within 28 days prior to registration.Xx_NEWLINE_xXCreatinine clearance or radioisotope GFR 70ml/min/1.73 m^2 orXx_NEWLINE_xXWithin 14 days prior to first dose of study drug treatment: Creatinine clearance >= 50 mL/minXx_NEWLINE_xXCalculated creatinine clearance must be > 60 mL and serum creatinine =< 2 mg/dLXx_NEWLINE_xXCreatinine clearance (calculated or measured) > 30 mL/minXx_NEWLINE_xXSerum creatinine < 1.5 mg/dl or creatinine clearance greater than 60/ ml per minute by the following formula (all tests must be performed within 28 days prior to registration)Xx_NEWLINE_xXCalculated creatinine clearance >= 50 mL/minXx_NEWLINE_xXObtained within 28 days prior to registration: Creatinine =< 1.5 mg/dL or creatinine clearance >= 60 mL/min is recommended; however, institutional norms are acceptableXx_NEWLINE_xXSerum creatinine =< 1.5 × ULN or creatinine clearance >= 50 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine =< 1.5 mg/dL; however, patients with a creatinine > 1.5 mg/dL but with a calculated creatinine clearance of > 60 ml/min, as measured by the Modification of Diet in Renal Disease (MDRD) equation, will be eligibleXx_NEWLINE_xXObtained =< 7 days prior to registration: Creatinine =< 2.0 mg/dL or creatinine clearance > 50 mL/minXx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN) OR calculated (calc.) creatinine clearance >= 30 mL/minXx_NEWLINE_xXCalculated (calc.) creatinine clearance > 45 mL/minXx_NEWLINE_xXWithin 14 days prior to registration: Serum creatinine =< 1.5 x institution’s ULN or calculated 24-hour creatinine clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dL or calculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXCreatinine OR =< 1.5 mg/dl x upper limit of normal (ULN) OR calculated (calc.) creatinine clearance > 45 mL/minXx_NEWLINE_xXCreatinine clearance >= 50 mL/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine =< ULN for the lab and measured or calculated creatinine clearance > 60 mL/min within 28 days before randomizationXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) or serum creatinine clearance (CrCl) >= 40 ml/minXx_NEWLINE_xXCreatinine clearance >= 60 mL/min/1.73 m^2Xx_NEWLINE_xXCalculated creatinine clearance > 70 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN) for the laboratory or calculated or actual creatinine clearance >= 60 mL/minXx_NEWLINE_xXSerum creatinine normal for age or calculated creatinine clearance (CrCl) >= 70 ml/min/1.73 m^2Xx_NEWLINE_xXCreatinine =< 1.5 x ULN and concurrent creatinine clearance (CrCl) >= 50 mL/min/1.73 m^2 for patients with creatinine (Cr) > 1.5 x ULNXx_NEWLINE_xXCreatinine clearance >= 50 mL/minXx_NEWLINE_xXDOSE ESCALATION COHORT: Serum creatinine ? 1.5 X ULN or creatinine clearance (CrCl) ? 50ml/minXx_NEWLINE_xXDOSE EXPANSION COHORT: Serum creatinine ? 1.5 X ULN or CrCl ? 50 ml/minXx_NEWLINE_xXWithin 28 days prior to administration of therapy: Creatinine clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine < 2.0 mg/dl, creatinine clearance >= 50 ml/mm (can be calculated or measured)Xx_NEWLINE_xXPatients must have a serum creatinine limit of =< 1.5 ULN or creatinine clearance of >= 60 ml/min measured within 14 days of registrationXx_NEWLINE_xXCreatinine clearance < 50 ml/minXx_NEWLINE_xXCalculated creatinine clearance >= 50 cc/minXx_NEWLINE_xXPatients must have serum creatinine =< 2 mg/dl with creatinine clearance >= 60 ml/min (either calculated or measured)Xx_NEWLINE_xXCreatinine < 1.5 mg/dl or creatinine clearance > 60 cc/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or creatinine clearance >= 40 ml/min/1.73 m^2 unless lymphoma relatedXx_NEWLINE_xXSerum creatinine less than or equal to 1.6 mg/ml or the creatinine clearance must be greater than 70 ml/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine =< the IULN OR measured or calculated creatinine clearance >= 50 mL/minXx_NEWLINE_xXCreatinine clearance >= 40 mL/minute (measured or calculated/estimated)Xx_NEWLINE_xXCreatinine =< 2.0 mg/dl (adults) or creatinine clearance > 40 ml/min. ); all adults with a creatinine > 1.2 or a history of renal dysfunction must have creatinine clearance (must be > 40 ml/min)Xx_NEWLINE_xXPatients must have a serum creatinine =< the IULN OR measured or calculated creatinine clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 × ULN or creatinine clearance >= 50 mL/minXx_NEWLINE_xXRenal function: calculated or measured creatinine clearance >= 50 ml/min and/or serum creatinine =< 1.6 mg/dlXx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN) for the laboratory or calculated or actual creatinine clearance > 45 mL/minXx_NEWLINE_xXMeasured or calculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/min within 14 days of enrollmentXx_NEWLINE_xXWithin 6 weeks prior to randomization, the most recent serum creatinine must be =< ULN or measured or calculated creatinine clearance must be > 60 mL/minXx_NEWLINE_xXSerum creatinine >= 1.5 times the upper normal limit or calculated/measured creatinine clearance =< 60 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL OR calculated creatinine clearance (Cockroft-Gault formula) >= 30 mL/min OR 24-hour urine creatinine clearance >= 30 mL/minXx_NEWLINE_xXBlood creatinine =< 1.5 mg/dL (if blood creatinine is > 1.5 mg/dL, calculate creatinine clearance using standard Cockcroft and Gault method or using a 24 hour urine collection for creatinine; creatinine clearance must be > 50 mL/min), within 2 weeks of the first dose of study treatmentXx_NEWLINE_xXCreatinine clearance >= 40 mL/min/1.73 m^2Xx_NEWLINE_xXCalculated or measured creatinine clearance >= 30 ml/min within 14 days prior to registrationXx_NEWLINE_xXA pretreatment measured creatinine clearance (absolute value) of >= 60 mL/minuteXx_NEWLINE_xXCreatinine < 2.0 mg/dL or creatinine clearance (CrCl) >= 60 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal OR creatinine clearance on a 24-h urine collection of >= 60 mL/minXx_NEWLINE_xXSerum creatinine less than or equal to 1.5 mg/dl unless the measured creatinine clearance is greater than 60 mL/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine =< 2.0 x upper limit of normal (ULN) or serum creatinine clearance (CrCl) >= 40 ml/minXx_NEWLINE_xXPatient with severe renal disease (i.e. creatinine greater than 3 times normal for age; creatinine clearance less than 50 ml/min/1.73m^2)Xx_NEWLINE_xXCreatinine clearance > 30 cc/minXx_NEWLINE_xXCreatinine ? 2 mg/dL OR creatinine clearance ? 50 mL/minXx_NEWLINE_xXCreatinine < 2.0 mg/dL OR creatinine clearance > 60 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine =< 1.5 times ULN OR measured creatinine clearance of >= 60 mL/min 1.73 m^2Xx_NEWLINE_xXCreatinine of less than 2.0 mg/dL, or if the patient has a serum creatinine >= 2.0, a measured creatinine clearance (Ccr) must be > 60 mL/min/1.73m^2Xx_NEWLINE_xXCreatinine clearance (calculated or 24 hour) >= 30 ml/minXx_NEWLINE_xXCreatinine < 2.0 mg/dL, or creatinine clearance > 60 mL/minXx_NEWLINE_xXSerum creatinine of < 1.5 mg/dl and/or creatinine clearance of > 60 mL/minXx_NEWLINE_xXCreatinine clearance >= 60 mL/min, unless secondary to renal involvement by lymphoma; for creatinine clearance < 50 mL/min due to kidney involvement by tumorXx_NEWLINE_xXSerum creatinine clearance (CrCl) >= 30 ml/minXx_NEWLINE_xXCalculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXCreatinine clearance (CrCL) (calculated creatinine clearance is permitted) > 40 mL/minXx_NEWLINE_xXCrCL >= 40 ml/minXx_NEWLINE_xXCreatinine clearance within 2 weeks of registration must be at least 60 ml/minXx_NEWLINE_xXCreatinine < 1.5 and creatinine clearance > 45Xx_NEWLINE_xXCreatinine =< 2.0 mg/dl or creatinine clearance > 50 ml/minXx_NEWLINE_xXCreatinine =< 1.4 mg/dL or creatinine clearance >= 50 mL/minXx_NEWLINE_xXCreatinine =< 1.5 mg/dl or creatinine clearance >= 50 ml/minXx_NEWLINE_xXObtained within 28 days prior to registration: Serum creatinine =< 1.5 x IULN OR measured or calculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXRenal Function (creatinine clearance or serum creatinine):Xx_NEWLINE_xXCalculated creatinine clearance ?60 mL/min/1.73m^2Xx_NEWLINE_xXCalculated creatinine clearance >= 40 mL/min using a serum creatinine or by 24-hour urine creatinine obtained within 28 days prior to registrationXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/min within four weeks prior to randomizationXx_NEWLINE_xXSerum creatinine ?1.5 × ULN or calculated creatinine clearance ?50 milliliters/minute.Xx_NEWLINE_xXSerum creatinine ? 1.5 x ULN; or a creatinine clearance ?40 mL/min;Xx_NEWLINE_xXSerum creatinine ? 2 x ULN or estimated creatinine clearance ? 50 ml/min.Xx_NEWLINE_xXSerum creatinine =< 1.5 times upper limit of normal (ULN) OR creatinine clearance (measured via 24-hour urine collection) >= 40 mL/minuteXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or creatinine clearance of >= 60 mL/min based on a 24-hour urine collectionXx_NEWLINE_xXCreatinine clearance (measured via 24-hour urine collection) >= 40 mL/minute (that is, if serum creatinine is > 1.5 x ULN, a 24-hour urine collection to calculate creatinine clearance must be performed)Xx_NEWLINE_xXSerum creatinine =< IULN OR measured or calculated creatinine clearance >= 60 mL/min be obtained within 42 days prior to registrationXx_NEWLINE_xXCalculated creatinine clearance (CrCl) > 30 mL/minXx_NEWLINE_xXCLINICAL/LABORATORY CRITERIA: Serum creatinine =< 1.5 x IULN OR measured or calculated creatinine clearance >= 40 mL/min; this result must have been obtained within 28 days prior to registrationXx_NEWLINE_xXEstimated creatinine clearance ? 30 mL/min.Xx_NEWLINE_xXCreatinine clearance 30 to 69 mL/min.Xx_NEWLINE_xXEstimated creatinine clearance ? 30 mL/min.Xx_NEWLINE_xXSerum creatinine ? 1.5 x ULN, or 24-hr clearance ? 60 mL/min,Xx_NEWLINE_xXEstimated Creatinine Clearance ?30 mL/minXx_NEWLINE_xXCreatinine clearance >= 50 mL/minXx_NEWLINE_xXCreatinine < 1.5 x the upper limit of normal (ULN) or calculated creatinine clearance of >= 50 ml/minXx_NEWLINE_xXCalculated creatinine clearance ? 30 mL/minXx_NEWLINE_xXCalculated Creatinine clearance>/= 45ml/minXx_NEWLINE_xXCalculated creatinine clearance >= 45 ml/minXx_NEWLINE_xXSerum creatinine =< 2.0 x upper limit of normal (ULN) or calculated creatinine clearance (CrCl) >= 30 mL/min obtained within 28 days prior to registrationXx_NEWLINE_xX(R) Renal insufficiency (serum creatinine >2 mg/dl)(177 µmol/L or more) or creatinine clearance < 40 ml/minXx_NEWLINE_xXRenal: Serum Creatinine ? 1.5 x ULN or creatinine clearance (CrCl) ? 60 mL/min as calculated by the Cockroft-Gault methodXx_NEWLINE_xXParts A and C: Renal function, as follows: serum creatinine ? 2.0 mg/dL, or measured 24 hour creatinine clearance of ? 45 mL/minXx_NEWLINE_xXMeasured or calculated creatinine clearance >= 40 ml/minXx_NEWLINE_xXAMKL PATIENTS: Creatinine < 1.5 x ULN or calculated creatinine clearance > 30 ml/minXx_NEWLINE_xXMF PATIENTS: Creatinine < 1.5 x ULN or calculated creatinine clearance > 30 ml/minXx_NEWLINE_xXSerum creatinine =< ULN within 14 days prior to registration OR calculated creatinine clearance > 50 ml/min; the serum creatinine value used in the calculation must have been obtained within 14 days prior to registrationXx_NEWLINE_xXCreatinine =< 2 x ULN or creatinine clearance (CrCl) > 30 ml/minXx_NEWLINE_xXCalculated creatinine clearance > 60 mL/minXx_NEWLINE_xXCreatinine clearance or estimated GFR . 60 mL/min/1.73m2Xx_NEWLINE_xXSerum creatinine (Cr) > 1.5 mg/dL or creatinine clearance < 50 ml/min/1.73 m^2 unless lymphoma relatedXx_NEWLINE_xXRenal: Creatinine clearance ?50mL/min;Xx_NEWLINE_xXAdequate renal function as assessed by serum creatinine ? 2.0 mg/dL; or calculated or 24-hour urine creatinine clearance >40 mL/min.Xx_NEWLINE_xXSerum creatinine < 2 mg/dL or creatinine clearance (CrCl) > 30 mL/minXx_NEWLINE_xXCalculated or measured creatinine clearance ? 40 mL/minXx_NEWLINE_xXserum creatinine clearance ?60 mL/minuteXx_NEWLINE_xXCreatinine ? 1.5 x ULN or Cr Cl > 60 cc/minXx_NEWLINE_xXAn average calculated creatinine clearance > 30 mL/min/1.73 m^2Xx_NEWLINE_xXRenal function: Estimated creatinine clearance ? 45 ml/min or serum creatinine ? 2.5 mg/dLXx_NEWLINE_xXPatients deemed to have severe renal impairment should not be considered for this study; patients with creatinine clearance (CrCl) of < 40 mL/min should be excludedXx_NEWLINE_xXSerum creatinine < 1.5 mg/dl or creatinine clearance (CC) ? 50 ml/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL OR an estimated creatinine clearance from 24 hour urine collection >= 50 ml/minXx_NEWLINE_xXCreatinine clearance inferior to 30 mL per min (MDRD Formula).Xx_NEWLINE_xXRenal: Serum Creatinine ? 1.5 x ULN or creatinine clearance (CrCl) ? 60 mL/min as calculated by the Cockroft-Gault methodXx_NEWLINE_xXCalculated creatinine clearance > 30 ml/minXx_NEWLINE_xXCalculated creatinine clearance > 50 mL/minXx_NEWLINE_xXCreatinine clearance >=50 milliliter per minutes (mL/min).Xx_NEWLINE_xXCalculated creatinine clearance > 50 mL/minute (Appendix 4)Xx_NEWLINE_xXCreatinine clearance or radioisotope GFR ? 70mL/min/1.73m2 or serum creatinine based on age/gender.Xx_NEWLINE_xXCreatinine clearance >= 60 ml/minuteXx_NEWLINE_xXSerum creatinine =< 2 md/dL or estimated creatinine clearance (CrCl) > 50ml/min/body surface area (BSA)Xx_NEWLINE_xXEstimated Creatinine Clearance ?30 mL/minXx_NEWLINE_xXPatients must have a creatinine clearance >= 30 ml/min within 28 days of registration to be eligible for the study; this will be determined by Cockroft-Gault calculation and 24-hour urine creatinine clearance measurement (please note, renal function, measured by 24-hour urine creatinine clearance in screening and post operatively, are required)Xx_NEWLINE_xXFor patients who have creatinine clearance that meets > 50 ml/min they must not have received prior systemic doxorubicinXx_NEWLINE_xXSerum creatinine =< 1.6 mg/dl or a calculated creatinine clearance >= 60 cc/minXx_NEWLINE_xXWithin 14 days of study start: Serum creatinine =< 1.5 x ULN, or 24-hr clearance >= 60 ml/min; andXx_NEWLINE_xXCalculated creatinine clearance must be >= 30 mL/minuteXx_NEWLINE_xXCreatinine clearance > 50 ml/minXx_NEWLINE_xXCreatinine =< 1.5 mg/dL x upper limits of normal (ULN) OR calculated (calc.) creatinine clearance >= 30 mL/minXx_NEWLINE_xXCalculated creatinine clearance > 60 ml/min; the serum creatinine value used in the calculation must have been obtained within 14 days prior to Step 2 RandomizationXx_NEWLINE_xXCalculated creatinine clearance > 60 ml/min; the serum creatinine value used in the calculation must have been obtained within 14 days prior to Step 3 registrationXx_NEWLINE_xXCreatinine clearance >= 30 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) for the lab, calculated creatinine clearance >= 60 mL/min or 24-hour creatinine clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x institution’s ULN or 24-hour creatinine clearance >= 50 ml/minXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXCalculated creatinine clearance (CrCL) of ? 45 mL/minXx_NEWLINE_xXSerum creatinine =< 2 x ULN or 24-hour creatinine clearance >= 60 ml/minXx_NEWLINE_xXCreatinine clearance (CrCl) >= 30 mL/minXx_NEWLINE_xXMeasured creatinine clearance > 50 ml/min or estimated creatinine clearance > 50 ml/minXx_NEWLINE_xXCreatinine clearance of >= 40 mL/min, estimated or calculatedXx_NEWLINE_xXSerum creatinine =< 1.5 x institution's ULN or 24-hour creatinine clearance >= 50 ml/minXx_NEWLINE_xXParticipant has serum creatinine ? 1.5 x ULN. If serum creatinine > 1.5 x ULN the calculated creatinine clearance should be > 40 milliliters/minute (mL/min)Xx_NEWLINE_xXHave calculated creatinine clearance (CrCL) ?30 mL/minute or serum creatinine ?1.5 times below the upper limit of normal.Xx_NEWLINE_xXCreatinine clearance >= 30 mL/minXx_NEWLINE_xXSerum Creatinine or Creatinine Clearance** ? 1.5 x ULN, > 50 mL/minXx_NEWLINE_xXSerum creatinine ?1.5 times institutional ULN or calculated creatinine clearance >30 mL/min;Xx_NEWLINE_xXSerum creatinine ? 1.5 × upper limit of normal (ULN) or creatinine clearance (CrCl) ? 40 mL/min/1.73 mXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or creatinine clearance >= 50mL/minXx_NEWLINE_xXSerum creatinine ? 1.5 × ULN or calculated or measured creatinine clearance ? 50 mL/min/1.73 m2Xx_NEWLINE_xXSerum creatinine ? 1.5 x upper limit of normal (ULN) or calculated creatinine clearance ? 60 mL/minuteXx_NEWLINE_xXCreatinine clearance ? 60 cc/minXx_NEWLINE_xXCreatinine =< 1.5 x ULN or creatinine clearance >= 60 mL/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or creatinine clearance >=50 mL/min.Xx_NEWLINE_xXCreatinine clearance (CrCL) >= 25 ml/minXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or calculated creatinine clearance >= 60 ml/minXx_NEWLINE_xXCreatinine =< ULN or a calculated creatinine clearance of >= 45 ml/min if creatinine is greater than the ULNXx_NEWLINE_xXCreatinine =< 1.5 x ULN or creatinine clearance (CrCl) calculated CrCl >= 60 mL/min/1.73m^2Xx_NEWLINE_xXEstimated creatinine clearance >= 30ml/minXx_NEWLINE_xXCreatinine clearance >= 40 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x IULN or a calculated or measured creatinine clearance >= 50 mL/min; these tests (including creatinine [mg/dl] if using calculated creatinine clearance) must be obtained within 14 days prior to registrationXx_NEWLINE_xXRenal: Estimated or measured creatinine clearance >= 60 mL/min.Xx_NEWLINE_xXCreatinine =< 2 x ULN or creatinine clearance (CrCl) > 30 ml/minXx_NEWLINE_xXRenal creatinine =< 1.5 X ULN OR calculated creatinine clearance >= 50 mL/min OR 24-hour urine creatinine clearance =< 1.5 X ULNXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXObtained within 14 weeks prior to registration on study: serum creatinine < 2.0 mg/dl and creatinine clearance > 40 mL/minXx_NEWLINE_xXSevere chronic renal disease (serum creatinine > 2.0 mg/dl and confirmed by creatinine clearance < 40 mL/minute)Xx_NEWLINE_xXCreatinine clearance (CrCl) >= 15 mL/minute, either measured or calculatedXx_NEWLINE_xXHas adequate renal function defined as serum creatinine or ? 1.5 × ULN and creatinine clearance or ? 40 ml/min.Xx_NEWLINE_xXSerum creatinine > 2 mg/dL OR creatinine clearance level (CrCL) < 30ml/minXx_NEWLINE_xXCalculated or measured creatinine clearance (CrCl) of ? 30 mL/minXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXSubject has severe renal impairment (creatinine clearance < 30 ml/min).Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN, or calculated creatinine clearance >= 60 ml/minXx_NEWLINE_xXCreatinine clearance >= 45 mL/minXx_NEWLINE_xXPediatric patients must have creatinine clearance >= 60 mL/min/1.73 m^2 regardless of serum creatinine levelXx_NEWLINE_xXSerum creatinine performed within 4 weeks prior to study entry must be less than or equal to 1.25 x ULN or estimated creatinine clearance less than 60 mL/min (as calculated using the method standard for the institutions).Xx_NEWLINE_xXDemonstrate adequate organ function as defined below, all screening labs should be performed within 28 days of treatment initiation\r\n* Absolute neutrophil count (ANC) >= 1,000/mcL\r\n* Platelets >= 75,000/mcL\r\n* Hemoglobin >= 9 g/dL\r\n* Serum creatinine =< 2 mg/dl OR creatinine clearance (if creatinine [Cr] > 2 mg/dL) >= 60 mL/min; creatinine clearance should be calculated per institutional standard\r\n* Serum total bilirubin =< 1.5 X upper limit of normal (ULN)\r\n* Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 X ULN\r\n* International normalized ratio (INR) =< 1.5 X ULN; activated partial thromboplastin time (aPTT) >= 1.5 X ULN; if on anticoagulant therapy (prothrombin time [PT] or PTT should be therapeutic)Xx_NEWLINE_xXObtained =< 21 days prior to registration: Estimated creatinine clearance >= 60 mL/min or a creatinine =< 2.2 mg/dLXx_NEWLINE_xXPatients must have adequate renal function, defined as serum creatinine ? 1.5 x ULN or creatinine clearance (calculated) ? 60 mL/min/1.73 m2 for patients with creatinine > 1.5 x ULN.Xx_NEWLINE_xXCreatinine (Cr) clearance >= 30 mL/minXx_NEWLINE_xXCalculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXCreatinine clearance > 45 mL/min (or serum creatinine [SCr] =< 1.5 mg/dL), normal within 2 weeks prior to start of treatmentXx_NEWLINE_xX24-hour (hr) creatinine clearance >= 30 cc/minXx_NEWLINE_xXCalculated creatinine clearance > 40 ml/min or 24 hour urineXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or 24-hour clearance >= 50 mL/minXx_NEWLINE_xXCalculate creatinine clearance >=40 millilitre/ minute (mL/min) (With the exception of those subjects who have Gilbert's syndrome; the bilirubin in these subjects should be at their baseline)Xx_NEWLINE_xXSerum creatinine > 2.0 x ULN; if creatinine 1.5 - 2.0 x ULN, creatinine clearance will be calculated according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula and patients with creatinine clearance < 30 mL/min should be excludedXx_NEWLINE_xXCreatinine clearance > 30 ml/minXx_NEWLINE_xXCalculated creatinine clearance ? 30 milliliter per minute (mL/min).Xx_NEWLINE_xXCreatinine clearance; calculated creatinine clearance (CrCl) >= 30 mL/min and < 60 mL/min (Cockroft-Gault) unless the patient qualified based on hearing loss or neuropathyXx_NEWLINE_xXCreatinine =< 1.5 mg/dL OR creatinine clearance (measured) >= 50 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or 24 hour creatinine (Cr) clearance > 50 ml/minXx_NEWLINE_xXCalculated creatinine clearance >= 45 mL/minXx_NEWLINE_xXCalculated creatinine clearance > 30 ml/minXx_NEWLINE_xXCalculated creatinine clearance of ? 45 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x the ULN or calculated creatinine clearance >= 60 ml/minXx_NEWLINE_xXSerum creatinine =< 2 mg/dL or calculated creatinine clearance of >= 40 ml/min within 14 days of registration using Modification of Diet in Renal Disease (MDRD) formulaXx_NEWLINE_xXCreatinine <1.5 X upper limit of normal or estimated plasma creatinine clearance of ?40 mL/minXx_NEWLINE_xXCreatinine =< 1.5 times ULN OR measured creatinine clearance > 60 mL/minXx_NEWLINE_xXPatient has a calculated or measured creatinine clearance of < 30 mL/minuteXx_NEWLINE_xXCreatinine clearance < 50 mL/minXx_NEWLINE_xXCreatinine < 1.5 mg/dl or creatinine clearance > 40 ml/minXx_NEWLINE_xXEstimated creatinine clearance (Clcr) >= 30 mL/minuteXx_NEWLINE_xXCalculated creatinine clearance ? 60 mL/min.Xx_NEWLINE_xXCreatinine clearance of >= 60 ml/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dl; creatinine (Cr) clearance should be > 50 mL/minXx_NEWLINE_xXCreatinine =< 1.8 mg/dL OR a calculated creatinine clearance >= 60 mL/hr within 4 weeks of enrollmentXx_NEWLINE_xXWithin 30 days prior to initiation of protocol treatment: Creatinine serum =< 1.5 mg/dL or creatinine clearance >= 45 mL/min\r\n* If calculated creatinine clearance is < 45 mL/min, a 24-hour urine collection for creatinine clearance may be performedXx_NEWLINE_xXSerum creatinine ? 1.5 × age-adjusted upper limit of normal (ULN) OR calculated creatinine clearance > 30 mL/minXx_NEWLINE_xXCreatinine clearance >= 50 mL/minXx_NEWLINE_xXCalculated creatinine clearance > 30 ml/minXx_NEWLINE_xXSerum creatinine =< 1.5 x institutional ULN or 24-hour clearance >= 50 mL/minXx_NEWLINE_xXCreatinine =< 1.5 times institutional upper limit of normal OR creatinine clearance >= 60ml/min/1.73m^2 measured by 24-hour urine collectionXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dl or creatinine clearance > 60 ml/minXx_NEWLINE_xXCreatinine < 2.0 mg/dL or creatinine clearance >= 50 mL/minXx_NEWLINE_xXCreatinine =< 2.0 mg/dL or creatinine clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL OR measured or calculated creatinine clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or 24-hour clearance >= 50 ml/minXx_NEWLINE_xXParticipants must not have a creatinine > 3 mg/dl or a GFR < 30 mL/min/1.73m^2Xx_NEWLINE_xXRenal function creatinine =< 2.0 mg/dL and/or creatinine clearance >= 50 ml/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL and/or creatinine clearance >= 50 mL/minXx_NEWLINE_xXCreatinine =< 1.5 mg/100 ml (or measured 24 hour creatinine clearance of >= 50 cc/min)Xx_NEWLINE_xXRenal: serum creatinine (sCr) ?2.0 x ULN, or creatinine clearance (Ccr) ?30 mL/min.Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL (133 umol/L)\r\n* Or, if > 1.5 mg/dL: calculated creatinine clearance (ClCR) >= 30 mL/min to >= 50 mL/minXx_NEWLINE_xXSerum creatinine < 1.6 mg/dl and/or measured creatinine clearance from 24-hour urine collection of >= 60 ml/minXx_NEWLINE_xXCreatinine clearance ? 60mL/minXx_NEWLINE_xXCreatinine clearance >= 45 mL/min; (creatinine < 2 mg/dL to receive cisplatin)Xx_NEWLINE_xXCreatinine < 1.8mg/mLXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or 24-hour clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or 24-hour clearance >= 50 ml/minXx_NEWLINE_xXRenal: Serum creatinine (sCr) ?1.5 x upper limit of normal, or creatinine clearance (Ccr) ?50 mL/min.Xx_NEWLINE_xXSerum creatinine =< 1.2 mg/dl or if serum creatinine is outside the normal range, then creatinine clearance (CrCl) > 40 ml/min (measured or calculated/estimated) with dose adjustment for fludarabine for < 70 ml/minXx_NEWLINE_xXSerum creatinine of =< 1.5 mg/dl or calculated creatinine clearance of >= 60 mL/minXx_NEWLINE_xXCreatinine (Cr) clearance >= 60 mL/minXx_NEWLINE_xXCalculated creatinine clearance (CRCL) > 60 mL/minXx_NEWLINE_xXAdults: calculated creatinine clearance must be > 60 mL and serum creatinine =< 2 mg/dLXx_NEWLINE_xXChildren (< 18 years old): calculated creatinine clearance must be > 60 mL/minXx_NEWLINE_xXCalculated creatinine (calc. creat.) clearance >= 60 ml/minXx_NEWLINE_xXCreatinine =< 1.5 x institutional ULN or creatinine clearance (calculated or measured) > 60 ml/minXx_NEWLINE_xXCreatinine clearance < 30Xx_NEWLINE_xXSerum creatinine =< 1.5 x institution's ULN or 24-hour creatinine clearance >= 50 ml/minXx_NEWLINE_xXSubjects with a determination of renal function based on: serum creatinine =< 1.5 mg/dL or if serum creatinine is outside the normal range, then creatinine clearance (CrCl) > 60-ml/min/1.73 m^2Xx_NEWLINE_xXEstimated creatinine clearance of >= 40 ml/minXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal OR calculated creatinine clearance >= 50 ml/minXx_NEWLINE_xXRenal: serum creatinine < 1.5 mg/dl or if serum creatinine is outside the normal range, then creatinine clearance (CrCl) > 40 ml/min (measured or calculated/estimated)Xx_NEWLINE_xXCreatinine Clearance of ? 50 mL/minXx_NEWLINE_xXEither serum creatinine >150 µmol/L (>1.7 mg/dL), or creatinine clearance <50 mL/min calculated by the Cockroft Gault method, eventually confirmed by measured creatinine clearance (or measured glomerular filtration rate (GFR) using plasma clearance methods, not gamma camera-based) <50 mL/min (the measured creatinine clearance / GFR is required only as confirmatory exam).Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or calculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXCreatinine clearance (calculated creatinine clearance is permitted) should be > 40 ml/minXx_NEWLINE_xXCalculated creatinine clearance ? 30 mL/min NOTE: Participants with a low creatinine clearance ? 60 mL/min (or ? 50 mL/min, according to lenalidomide prescribing information/local practice) were to receive a reduced lenalidomide dose of 10 mg once daily (QD) on Days 1 through 21 of a 28-day cycle. The lenalidomide dose may have been escalated to 15 mg QD after 2 cycles if the participant was not responding to treatment and was tolerating the treatment. If renal function normalized (ie, creatinine clearance >60 mL/min or >50 mL/min, according to lenalidomide prescribing information/local practice) and the participant continued to tolerate this treatment, lenalidomide may then have been escalated to 25 mg QD.Xx_NEWLINE_xXSerum creatinine < 1.4 mg/dl or creatinine clearance >= 60 ml/min (prior to start of radiation)Xx_NEWLINE_xXCreatinine clearance: the standard Cockcroft and Gault formula must be used to calculate creatinine clearance (CrCl) for enrollment or dosing; also include in the pre-treatment or baseline text portion of the protocol, the 'On Study Evaluations or During Treatment' for every pemetrexed treatment day, and also capture in the study Schedule of Events; no dosage adjustment is needed in patients with creatinine clearance > 45 mL/min; insufficient numbers of patients have been studied with creatinine clearance < 45 mL/min to give a dose recommendation; therefore, pemetrexed should not be administered to patients whose creatinine clearance is < 45 mL/minXx_NEWLINE_xXIf > 1.5 mg/dL, calculated creatinine clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x the upper limit of normal (ULN) or calculated creatinine clearance >= 40 mL/minXx_NEWLINE_xXSerum creatinine of < 2 mg/dl or creatinine clearance of > 50 cc/minXx_NEWLINE_xXThe patient has serum creatinine <2×ULN and not rising for at least 2-4 weeks before chemotherapy. If elevated, the 24-hour creatinine clearance must be >50 mL/minXx_NEWLINE_xXCreatinine clearance >= 50 mL/minXx_NEWLINE_xXCreatinine clearance (CrCl) > 50 mL/minXx_NEWLINE_xXCreatinine =< 2.0 mg/dL or creatinine clearance >= 50 mL/minXx_NEWLINE_xXcreatinine clearance of < 30 mL/minXx_NEWLINE_xXPatients with severe renal impairment (creatinine clearance [CrCl] < 30 mL/min); a calculated CrCl is acceptableXx_NEWLINE_xXCreatinine < 1.5 mg/dL; if question about renal function discuss with study chairman and do 24 hour creatinine clearance (clearance should be > 50 ml/min)Xx_NEWLINE_xXSerum creatinine of ?1.5 × the upper limit of normal (ULN)OR estimated creatinine clearance (CrCl) ? 40 ml/min/1.73 m2Xx_NEWLINE_xXCreatinine clearance >= 50 ml/mm (can be calculated)Xx_NEWLINE_xXCreatinine =< 2.0 mg/100 mlXx_NEWLINE_xXAdequate renal function defined by measured creatinine clearance >= 50 mL/min by a 24-hour urine collectionXx_NEWLINE_xXCreatinine clearance of > 60 ml/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or creatinine clearance >= 50 mL/min based on a 24-hour urine collectionXx_NEWLINE_xXEstimated creatinine clearance < 50 ml/minXx_NEWLINE_xXRenal insufficiency of creatinine clearance <40mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) or calculated creatinine clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dl or a calculated creatinine clearance >= 60 cc/minXx_NEWLINE_xXMust have adequate organ function as defined by the following baseline values: Absolute neutrophil count (ANC) >/=1.5x10^9/L Hemoglobin >/=9 g/dL Platelets >/=100x10^9/L Prothrombin time /International normalized ratio (INR) and partial thromboplastin time </=1.5xULN (Subjects receiving anticoagulation treatment may be allowed to participate with INR established within the therapeutic range prior to starting study treatment.) Total bilirubin </=1.5 x upper limit of normal (ULN) Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) </= 2.5xULN Serum creatinine </=1.5 mg/dL (if serum creatinine is >1.5 mg/dL, calculate creatinine clearance using standard Cockcroft and Gault; creatinine clearance must be > 50 mL/min); creatinine clearance should be >/= 50 mL/min Left ventricular ejection fraction >/= institutional lower limit of normal ECHOXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or calculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or calculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 X ULN OR 24-hour creatinine clearance >= 60 mL/minXx_NEWLINE_xXPatients must have an estimated creatinine clearance greater than 50/ml per minute (serum creatinine value must be within 28 days prior to registration)Xx_NEWLINE_xXSerum creatinine =< 1.5 x the upper limit of normal or creatinine clearance >= 60 mL/min (measured or calculated)Xx_NEWLINE_xXSerum creatinine =< 1.5 x the upper limit of normal or calculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dl and a creatinine clearance >= 30 ml/minXx_NEWLINE_xXCreatinine clearance estimated to be >= 30 ml/minXx_NEWLINE_xXPatient has a calculated or measured creatinine clearance of < 20 ml/minute within 14 days before enrollmentXx_NEWLINE_xXSerum creatinine < 2.5 mg/dL or creatinine clearance > 40ml/minXx_NEWLINE_xXRenal: serum creatinine =< 1.2 mg/dl or if serum creatinine is outside the normal range, then creatinine clearance (CrCl) > 40 ml/min (measured or calculated/estimated) with dose adjustment of fludarabine for < 70 ml/minXx_NEWLINE_xXSerum creatinine ? 1.5 × ULN according to institutional standards or creatinine clearance ? 50 mL/minXx_NEWLINE_xXCreatinine < 1.5 x ULN OR calculated creatinine clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine ?1.5 x ULN or calculated 24-hour creatinine clearance ?60 mL/minuteXx_NEWLINE_xXCreatinine clearance (CrCl) < 30mL/minXx_NEWLINE_xXSerum creatinine ?1.5 x upper limit of normal (ULN) or a calculated creatinine clearance >60 mL/min,Xx_NEWLINE_xXCreatinine =< 1.5 x ULN OR calculated creatinine clearance >= 60 ml/minXx_NEWLINE_xXInadequate renal function defined as measured creatinine clearance less than 50 mL/min/1.73 m^2 based on the Cockcroft-Gault formula (adults) or Schwartz formula (age less than or equal to 12 years). Adults: estimated creatinine clearance rate (eCCr) (mL/min/) = (140 - age) x mass (kg) x (0.85 if female)/72 x serum creatinine (mg/dL; Creatinine clearance (mL/min/1.73m^2) = eCCr x 1.73/Body Surface Area (BSA) (m^2); Children: eCCr (mL/min/1.73 m^2) = k x height (cm) / serum creatinine (mg/dL) k = 0.33 (pre-term), 0.45 (full term to 1 year old), 0.55 (age 1-12 years).Xx_NEWLINE_xXCalculated creatinine clearance > 30 mL/min/1.73 m^2Xx_NEWLINE_xXEstimated creatinine clearance (CCL) > 60 cc/minXx_NEWLINE_xXCalculated creatinine clearance >= 45 ml/minXx_NEWLINE_xXCreatinine < 2.0 mg/100 mlXx_NEWLINE_xXCreatinine =< 1.5 x laboratory upper limit of normal or calculated creatinine clearance of >= 50 ml/minXx_NEWLINE_xXCreatinine (Cr) =< 1.5 mg/dL x upper limit of normal (ULN), creatinine clearance (CrCl) >= 50 mL/min calculated by the Cockroft-Gault methodXx_NEWLINE_xXSubjects must have calculated creatinine clearance >= 30 ml/minXx_NEWLINE_xXSerum creatinine > 2.0 mg/dL or calculated creatinine clearance < 30 ml/minXx_NEWLINE_xXCreatinine =< 1.5 mg/dL or creatinine clearance >= 60 ml/minXx_NEWLINE_xXCreatinine clearance < 40 ml/minXx_NEWLINE_xXEither serum creatinine =< 1.5 mg/dL or measured creatinine clearance >= 60 mL/minXx_NEWLINE_xXEstimated creatinine clearance >= 60 mL/min or a creatinine =< 2.2 mg/dL obtained =< 14 days prior to registrationXx_NEWLINE_xXSerum creatinine < 1.6 mg/dL or creatinine clearance >= 50 ml/minXx_NEWLINE_xXSerum creatinine =< 2.0 x upper limit of normal (ULN) or serum creatinine clearance (CrCl) >= 40 ml/min (drug is not cleared by the kidney)Xx_NEWLINE_xXPatients must have a creatinine clearance greater than 50/ml per minute by the following formula (test must be performed within 28 days prior to registration):\r\n* Creatinine clearance (CrCl) = (140-age) (Wt in Kg) x 0.85 (female) OR 1.0 (male)/72 x serum CrXx_NEWLINE_xXCreatinine =< 1.5 mg/dl and creatinine clearance >= 50 ml/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine =< 2 x the institutional ULN and measured or estimated creatinine clearance >= 50 cc/minXx_NEWLINE_xXPatients must have either (a) normal kidney function (i.e. creatinine =< 1.5 X upper limit of normal [ULN] OR calculated creatinine clearance >= 60 mL/min by the modified Cockcroft and Gault Formula OR a creatinine clearance >= 60 mL/min obtained from a 24-hour urine collection) or (b) moderate or severe renal dysfunction (i.e. creatinine clearance < 60 mL/min and >= 20 mL/min)Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dl or creatinine clearance > 50 ml/minXx_NEWLINE_xXBaseline serum-creatinine > 2.0 mg/dl and a calculated or measured creatinine clearance of < 50 ml/minuteXx_NEWLINE_xXPatients with a creatinine clearance < 60 ml/min/1.73 m^2 body surface areaXx_NEWLINE_xXCreatinine clearance (Clcr) > 25 mL/minXx_NEWLINE_xXCreatinine clearance >= 40 ml/minXx_NEWLINE_xXSerum creatinine <1.5 x upper limit of normal (ULN) or estimated creatinine clearance 60 mL/min (as calculated using the standard method of the institution);Xx_NEWLINE_xXSerum creatinine < 1.5 mg/dL or creatinine clearance greater than or equal to 40 cc/min as defined by Modification of Diet in Renal Disease (MDRD) method from National Kidney Disease Education Program (NKDEP)Xx_NEWLINE_xXcreatinine clearance < 70 mL/min, orXx_NEWLINE_xXAdequate renal function defined as serum creatinine ? 1.5x upper limit of normal (ULN) for age. If the serum creatinine is above these values, the calculated creatinine clearance or radioisotope GFR must be ? 70 mL/min/1.73m2.Xx_NEWLINE_xXCreatinine of measured or calculated creatinine clearance of >= 50 cc/minXx_NEWLINE_xXEstimated creatinine clearance (CLcr) > 25 ml/minXx_NEWLINE_xXCreatinine (Cr) < 1.5 mg/dL or creatinine clearance > 50 mL/min/m^2Xx_NEWLINE_xXCreatinine clearance of >= 60 ml/minXx_NEWLINE_xXCreatinine =< 2.0 X ULN OR creatinine clearance >= 30 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine clearance >= 60 ml/mmXx_NEWLINE_xXSerum creatinine (Cr) =< 2 x ULN or 24-hour creatinine clearance >= 50 ml/minXx_NEWLINE_xXAdequate renal function, defined as serum creatinine ? 2.0 times ULN and creatinine clearance > 50 mL/minXx_NEWLINE_xXRenal clearance CCR < 40 mL/minXx_NEWLINE_xXRenal: serum creatinine (sCr) ?2.0 x ULN, or creatinine clearance (Ccr) ?30 mL/min.Xx_NEWLINE_xXRenal: Serum creatinine within normal range for age, or if serum creatinine outside normal range for age, then renal function (creatinine clearance or GFR) > 70mL/min/1.73m2.Xx_NEWLINE_xXRenal function\r\n* ARM A: Creatinine clearance > 60 ml/min\r\n* ARM B: No limitationXx_NEWLINE_xXRenal function: Age-adjusted normal serum creatinine is required. A 24-hour creatinine clearance value > 60 mL/min/1.73 m2 (updated Schwartz formula or nuclear GFR) must be obtained if serum creatinine is elevated.Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or 24-hour clearance >= 50 mL/minXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXCreatinine clearance >= 30 ml/minXx_NEWLINE_xXCreatinine clearance > 30 mL/minXx_NEWLINE_xXSerum creatinine within normal limits or calculated clearance ? 50 mL/min/1.73 m2 for subjects with serum creatinine levels above or below the institutional normal value. If using creatinine clearance, actual body weight should be used for calculating creatinine clearance (eg, using the Cockroft-Gault formula). For subjects with a body mass index (BMI) > 30 kg/m2, lean body weight should be used instead.Xx_NEWLINE_xXRenal: Serum creatinine < 1.5 x ULN OR calculated creatinine clearance (CLcr) ? 60 ml/minXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dl or creatinine clearance >= 60 mL/minXx_NEWLINE_xXSerum creatinine < 2 x ULN or creatinine clearance > 60 mL/minXx_NEWLINE_xXRenal: Serum creatinine < ULN OR calculated creatinine clearance (CLcr) of ? 60 ml/minXx_NEWLINE_xXCreatinine =< 1.5 x laboratory upper limit of normal or calculated creatinine clearance of >= 50 mL/min (please use institutional formula)Xx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 X ULN and stable X 1 month OR creatinine clearance >= 60 Ml/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine < ULN OR calculated creatinine clearance (CrCl) of ? 60 ml/minXx_NEWLINE_xXSerum creatinine < 1.5 x ULN or creatinine clearance ? 60 mL/min as measured by institutional standardsXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dl and/or creatinine clearance >= 50 mL/minXx_NEWLINE_xXCreatinine clearance >= 30 mL/minXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXCalculated creatinine clearance (CrCl) of greater than or equal to 50 or serum creatinine less than 2 x ULN; even if organ function abnormalities are considered due to tumor, the upper limit for creatinine is less than or equal to 2 mg/dLXx_NEWLINE_xXCreatinine < 1.8 mg/dl (or creatinine clearance > 40 ml/min)Xx_NEWLINE_xXSerum creatinine >1.5 x ULN or creatinine clearance ? 45 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/minXx_NEWLINE_xXCreatinine Clearance ? 50 ml/minXx_NEWLINE_xXCreatinine clearance < 30 ml/min which cannot be attributed to MCC metastasisXx_NEWLINE_xXPatients with creatinine clearance: < 50 mL/min are excluded from this protocol; capecitabine is contraindicated in severe renal impairment (clearance < 40 mL/min)Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or calculated creatinine clearance > 50 mL/minXx_NEWLINE_xXCreatinine clearance ? 30 mL/minXx_NEWLINE_xXCreatinine clearance > 50 ml/minXx_NEWLINE_xXSerum creatinine < 1.5 x upper limit of normal (ULN) or serum creatinine clearance (CrCl)> 40ml/min (CrCl= Wt (kg) x (140-age)*/72 x Cr. level, *female x 0.85)Xx_NEWLINE_xXAdequate renal function (creatinine clearance greater than equal to (?) 45 milliliters per minute [mL/min])Xx_NEWLINE_xXCreatinine clearance must be > 60ml/minXx_NEWLINE_xXCreatinine clearance >= 30 mL/minuteXx_NEWLINE_xXUrothelial cancer patients should be ineligible for cisplatin based on one or more of the following:\r\n* Calculated creatinine clearance of < 60 mL/min (but >= 30 mL/min)\r\n* Solitary kidney\r\n* Karnofsky performance status < 80%Xx_NEWLINE_xXSerum creatinine < 2 or calculated creatinine clearance (CrCl) >= 30 mL/minXx_NEWLINE_xXCreatinine > 2.0 times upper normal limit and creatinine clearance < 30 ml/min/m^2; patients with creatinine > 2 times upper limit of normal will have creatinine clearance estimated; at the discretion of treating physician, creatinine clearance can be measured and that value can be used instead of calculated creatinine clearanceXx_NEWLINE_xXTREATMENT: Serum creatinine less than or equal to 1.6 mg/ml or the creatinine clearance must be greater than 70 ml/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dl or measured or calculated creatinine clearance >= 50 ml/minXx_NEWLINE_xXCalculated or measured creatinine clearance (CrCl) >= 30 mL/minXx_NEWLINE_xXCreatinine clearance >= 40mL/minXx_NEWLINE_xXCalculated creatinine clearance of ? 60 ml/min.Xx_NEWLINE_xXCreatinine =< 1.5 x laboratory upper limit of normal or calculated creatinine clearance of >= 50 ml/minXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN), or, calculated creatinine clearance (CrCl) >= 50 mL/minXx_NEWLINE_xXRenal impairment at baseline as measured by serum creatinine clearance (CrCl) ?60 mL/min ?21 days prior to registration.Xx_NEWLINE_xXSerum creatinine ? 2.0 mg/dL or calculated creatinine clearance of ? 60 mL/minXx_NEWLINE_xXPatient must have adequate renal function as defined by a calculated creatinine clearance of >30 mL/min per 1.73 m[2] determined using the Schwartz equation: Creatinine clearance (ml/min per1.73 m[2]= (height [cm] x k)/ (serum creatinine [mg/dL]) where k is a standard proportionality constant based on patient's gestational age, chronologic age and gender.Xx_NEWLINE_xXCreatinine =< 1.5 x upper limits of normal (ULN); if creatinine (Cr.) > 1.5 x ULN, then calculated creatinine clearance > 40 cc/minXx_NEWLINE_xXSerum Creatinine < 1.5 x ULN (upper limit of normal) or estimated creatinine clearance ? 60 mL/min, as calculated using method standard for the institution (Appendix 2).Xx_NEWLINE_xXHas adequate organ function: AST and ALT < 3X the ULN, serum bilirubin < 2X the ULN, serum creatinine of < 2 mg/dL, or a calculated creatinine clearance of > 50 mL/minuteXx_NEWLINE_xXCalculated creatinine clearance >= 40 ml/min or 24 hour urineXx_NEWLINE_xXCreatinine clearance equal or > 50 ml/min (calculated)Xx_NEWLINE_xXCreatinine clearance < 50 ml/min (calculated)Xx_NEWLINE_xXCreatinine clearance >= 50 ml/minXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN, or 24-hour (hr) clearance >= 60 ml/minXx_NEWLINE_xXCreatinine clearance > 25 mL/min or creatinine =< 1.5 mg/dLXx_NEWLINE_xXSevere renal impairment (creatinine clearance =< 30 ml/min)Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/minXx_NEWLINE_xXSerum creatinine ? 1.5 x upper limit of normal (ULN) or calculated creatinine clearance > 60 mL/min if the serum creatinine is > 1.5 x ULNXx_NEWLINE_xXA measured or estimated creatinine clearance (CrCl) ?60 mL/min/1.73 m2Xx_NEWLINE_xXCreatinine ?2.0 x ULN or Creatinine Clearance ?40 mL/minXx_NEWLINE_xXCreatinine =< 1.5 mg/dL or creatinine clearance > 60 ml/minXx_NEWLINE_xXCreatinine (Cr) clearance > 50 mL/min by Modification of Diet in Renal Disease (MDRD) calculationXx_NEWLINE_xXSerum creatinine ? 1.5 x ULN, or calculated creatinine clearance ? 40 mL/min (if renal impairment is suspected 24-hour urine collection for measurement is required).Xx_NEWLINE_xXCalculated or measured creatinine clearance >= 50 ml/min or serum creatinine =< 1.6 mg/dlXx_NEWLINE_xXAdequate renal function as evidenced by: serum creatinine ?2.0 × ULN; OR creatinine clearance > 40 mL/min based on the Cockroft-Gault GFR estimation: (140 - Age) x (weight in kg) x (0.85 if female)/72 x serum creatinineXx_NEWLINE_xXSerum creatinine >= 1.5 times the upper normal limit or calculated/measured creatinine clearance =< 60 mL/minXx_NEWLINE_xXCreatinine clearance ? 50 mL/minXx_NEWLINE_xXCreatinine ? 1.5 x ULN, or calculated or measured creatinine clearance ? 50 mL/min, or 24-hour measured urine creatinine clearance ? 50 mL/min.Xx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal OR creatinine clearance on a 24-h urine collection of >= 50 mL/minXx_NEWLINE_xXCreatinine clearance of 50 or greaterXx_NEWLINE_xXPatients with a creatinine clearance of less than 50 are ineligibleXx_NEWLINE_xXCreatinine < 2.0 x upper limit of normal and/or a creatinine clearance >= 60 ml/minXx_NEWLINE_xXPatient must have a calculated creatinine clearance or radioisotope GFR > 60mL/min/1.73m2 or a normal serum creatinine based on age/genderXx_NEWLINE_xXCreatinine clearance > 40Xx_NEWLINE_xXSerum creatinine <=1.2 mg/dL or calculated/measured creatinine clearance >=50 mL/minuteXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN (or 24-hour creatinine clearance >= 50 ml/min)Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN and creatinine clearance > 30 ml/minXx_NEWLINE_xXEstimated serum creatinine clearance >= 50 ml/min (Modification of Diet in Renal Disease [MDRD] method from National Kidney Disease Education Program, [NKDEP]) and/or serum creatinine =< 1.8 mg/dLXx_NEWLINE_xXSerum creatinine <=1.5 mg/dL (If serum creatinine is >1.5 mg/dL, calculate creatinine clearance using standard Cockcroft and Gault Method Creatinine clearance must be >50 mL/min)Xx_NEWLINE_xXCreatinine clearance > 40 ml/minXx_NEWLINE_xXAdequate renal function as demonstrated by serum creatinine ? 1.5 x ULN, or 24-hr urine creatinine clearance calculation >60 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dl or measured creatinine clearance of > 30 ml/minXx_NEWLINE_xXCalculated or measured creatinine clearance >= 45 mL/minXx_NEWLINE_xXSerum Creatinine ? 1.5 x ULN, or Creatinine Clearance > 45mL/minXx_NEWLINE_xXRenal: serum creatinine WNL or calculated creatinine clearance ? 50 mL/min/1.73m2 for patients with creatinine levels above institutional normalXx_NEWLINE_xXCreatinine clearance >= 50 cc/minXx_NEWLINE_xXSerum creatinine less than 1.6 mg/dl and creatinine clearance >= to 30 mL/minXx_NEWLINE_xXCreatinine >= 1.5 × ULN for the institution (or a calculated creatinine clearance < 60 mL/min/1.73 m2)Xx_NEWLINE_xXEstimated creatinine clearance of ?40 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN OR calculated creatinine clearance >= 50 mL/minXx_NEWLINE_xXCreatinine clearance >= 50 mL/minXx_NEWLINE_xXA calculated creatinine clearance (CrCl) that meets entry criteria for enrollment (ie, calculated CrCl either ? 90 or < 30 mL/minXx_NEWLINE_xXAdequate renal function (serum creatinine =< 2.0 mg/dL or creatinine clearance >= 50 ml/min)Xx_NEWLINE_xXSerum creatinine > 1.5× ULN (or a calculated creatinine clearance < 60 mL/min/1.73 m2)Xx_NEWLINE_xXCalculated creatinine clearance by Modification of Diet in Renal Disease (MDRD) (CrCL) > 50 ml/min/1.73 squared meterXx_NEWLINE_xXKidney disease with a calculated creatinine clearance <30% normal value.Xx_NEWLINE_xXEither creatinine > 2.0 mg/dL or creatinine clearance < 30 mL/minXx_NEWLINE_xXcreatinine <2.0 mg/dL OR creatinine clearance >50 mL/min/1.73 m2Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or 24-hour clearance >= 50 mL/minXx_NEWLINE_xXMeasured creatinine clearance >= 60 mL/minXx_NEWLINE_xXSerum creatinine ?2 mg/dL or creatinine clearance > 60 mL/minute;Xx_NEWLINE_xXChronic or acute renal insufficiency as defined by a preoperative serum creatinine greater than 1.5mg/dL or creatinine clearance of < 60 ml/minXx_NEWLINE_xXCalculated creatinine clearance (CrCl) >= 50 mL/min (modification of diet in renal disease [MDRD] Formula)Xx_NEWLINE_xXCreatinine < 1.5 x the upper limit of normal (ULN) or calculated creatinine clearance >= 50 cc/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or creatinine clearance >= 60 mL/min based on 24-hour urine collectionXx_NEWLINE_xXCreatinine clearance >= 40 mL/minXx_NEWLINE_xXSerum creatinine ? 2.0 mg/dL or calculated creatinine clearance ?60 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or 24-hour creatinine clearance >= 50 ml/minXx_NEWLINE_xXCalculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXPatient has a calculated or measured creatinine clearance of < 20 mL/minute within 14 days prior to treatment initiationXx_NEWLINE_xXDonor must have adequate renal function as defined by a minimum creatinine clearance (CrCl) value of >30 ml/min.Xx_NEWLINE_xXSevere renal impairment: estimated creatinine clearance (CrCl) <30 ml/min, but not requiring dialysisXx_NEWLINE_xXCalculated creatinine clearance > 30 ml/min (unless demonstrated Hodgkin lymphoma involvement of the kidney)Xx_NEWLINE_xXAdequate renal function, defined as Creatinine Clearance >60 mL/min or serum creatinine of ? 1.3 mg/dL (115 ?M).Xx_NEWLINE_xXCreatinine Clearance < 45 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 X ULN or 24-hour clearance >= 55 mL/minXx_NEWLINE_xXSubjects with creatinine clearance ?10 mL/min who are not being treated with continuous renal replacement therapy (CRRT).Xx_NEWLINE_xXMDRD calculated or measured CrCl of ?30 mL/minXx_NEWLINE_xXMDRD calculated or measured CrCl of ?30 mL/minXx_NEWLINE_xXPatients must have a serum creatinine within normal limits, or an estimated or measured creatinine clearance >= 65 ml/minXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXCreatinine clearance (CrCl) ? 50 mL/minute within 21 days prior to randomizationXx_NEWLINE_xXCalculated creatinine clearance > 50 mL/min.Xx_NEWLINE_xXTotal Cumulative Illness Rating Scale (CIRS) > 6 and/or creatinine clearance < 70 ml/minXx_NEWLINE_xXEstimated serum creatinine clearance > 60 ml/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or calculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXCreatinine clearance >= 40 ml/min; creatinine clearance will be determined by testing of a 24 hour urine collection and simultaneous serum creatinine valueXx_NEWLINE_xXCreatinine clearance > 60 mL/min/1.73 m^2 or normal age adjusted serum creatinine (=< 5 years [yrs.] =< 0.8 mg/ml; 5-10 yrs. =< 1.0 mg/ml; 10-15 yrs. =< 1.2 mg/ml; > 15 yrs. =< 1.5 mg/ml)Xx_NEWLINE_xXCreatinine clearance > 60 mL/min/1.72 m^2 or normal age adjusted serum creatinine (=< 5 yrs. =< 0.8 mg/ml; 5-10 yrs. =< 1.0 mg/ml; 10-15 yrs. =< 1.2 mg/ml; > 15 yrs. =< 1.5 mg/ml)Xx_NEWLINE_xXCreatinine clearance > 60 mL/min/1.73 m^2 or normal age adjusted serum creatinine (=< 5 yrs. =< 0.8 mg/ml; 5-10 yrs. =< 1.0 mg/ml; 10-15 yrs. =< 1.2 mg/ml; > 15 yrs. =< 1.5 mg/ml)Xx_NEWLINE_xXCreatinine =< 1.5 mg/dl and/or creatinine clearance >= 60 mL/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine of <=2.0 mg/dL or creatinine clearance >=50 mL/minXx_NEWLINE_xXThe participant has adequate renal function as defined by serum creatinine ? 1.5 x the institutional ULN or creatinine clearance ? 60 milliliter/minute (mL/min) for participants with creatinine levels above the ULNXx_NEWLINE_xXCalculated creatinine clearance > 50 mL/min.Xx_NEWLINE_xXSerum creatinine < 2mg/dl and calculated creatinine clearance >10ml/min.Xx_NEWLINE_xXCreatinine clearance of > 40 ml/min/1.73m^2Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or creatinine clearance (CrCl) >= 40 mL/minXx_NEWLINE_xXCreatinine =< 3 mg/dL and creatinine clearance (CrCL) >= 25 ml/minXx_NEWLINE_xXEstimated serum creatinine clearance >= 50 ml/min and/or serum creatinine =< 1.8 mg/dLXx_NEWLINE_xXCreatinine clearance >= 25 mL/minXx_NEWLINE_xXSerum creatinine less than or equal to 1.6 mg/ml or the creatinine clearance must be greater than 70 ml/min/1.73m^2Xx_NEWLINE_xXCalculated creatinine clearance > 20 mL/min per institutional standardXx_NEWLINE_xXSerum creatinine < 1.5 mg/dl and/or calculated or measured creatinine clearance (CrCl) >= 30 ml/minXx_NEWLINE_xXCalculated or measured creatinine clearance >= 60 mL/minXx_NEWLINE_xXCreatinine clearance >= 30 mL/minXx_NEWLINE_xXCreatinine =< 2.0 mg/dL or calculated creatinine clearance >= 40Xx_NEWLINE_xXMust have a serum creatinine < 2.0 and creatinine clearance > 30 ml/min/m^2; other organ dysfunction is eligible at the discretion of the Principal Investigator (PI)Xx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/min\r\n* For females, use 85% of calculated creatinine clearance (CrCl) valueXx_NEWLINE_xXSerum creatinine =< 3 mg/dL and creatinine clearance >= 30 ml/minXx_NEWLINE_xXPatients with a creatinine clearance of < 60 ml/minXx_NEWLINE_xXRenal: creatinine clearance >=60 milliliter per minute (mL/min).Xx_NEWLINE_xXCrCL ? 40 mL/minXx_NEWLINE_xXRenal insufficiency (defined as calculated creatinine clearance < 30 mL/min)Xx_NEWLINE_xXPatients with severe renal insufficiency, defined and confirmed by an estimated creatinine clearance equal or lower than 30 mL/min, per institutional laboratory.Xx_NEWLINE_xXSevere renal impairment (calculated creatinine clearance =< 29 cc/min)Xx_NEWLINE_xXPatients with severe renal impairment defined as creatinine clearance of 15-29 mL/min and/or diagnosed with stage 4 chronic kidney diseaseXx_NEWLINE_xXCreatinine clearance (calculated or measured) of < 50 cc/minuteXx_NEWLINE_xXCreatinine > 1.5 x ULN or creatinine clearance levels (CrCL) < 45 mL/minXx_NEWLINE_xXModerate to severe renal failure (creatinine clearance [Clcr] < 30 mL/min)Xx_NEWLINE_xXPatients with a creatinine clearance < 30 mL/minXx_NEWLINE_xXAcute or chronic renal insufficiency with creatinine clearance < 30 mL/min, drawn within 28 days of consentXx_NEWLINE_xXCalculated creatinine clearance < 30 ml/min; creatinine clearance will be calculated using the Modification of Diet in Renal Disease (MDRD) methodXx_NEWLINE_xXRenal: serum creatinine < 1.2 mg/dl or if serum creatinine is outside the normal range, then creatinine clearance (CrCl) > 50 ml/min (measured or calculated/estimated)Xx_NEWLINE_xXMeasured creatinine clearance more than 60 mL/min; the updated Schwartz formula should be used for pediatric patients (>= 5 to 12 years old)Xx_NEWLINE_xXSerum creatinine =< 3 mg/dL (265 umol/L) and creatinine clearance >= 30 ml/minXx_NEWLINE_xXPatients must have a calculated creatinine clearance > 30 mL/min; the serum creatinine value used in the calculation must have been obtained within 28 days prior to registrationXx_NEWLINE_xXChronic kidney disease or in participants without known kidney disease, estimated creatinine clearance of =< 30 ml/min, even after rehydrationXx_NEWLINE_xXMaximum serum creatinine of 1.5 mg/dL OR a creatinine clearance >= 70 ml/min/1.73m^2Xx_NEWLINE_xXCreatinine clearance >= 50 ml/minXx_NEWLINE_xXEstimated creatinine clearance ? 50ml/minXx_NEWLINE_xXCreatinine clearance >= 30 mL/minXx_NEWLINE_xXCreatinine clearance ?60 milliliters/minute.Xx_NEWLINE_xXCreatinine =< 1.5 mg/dl and/or creatinine clearance >= 60 mL/minXx_NEWLINE_xXEstimated creatinine clearance (CrCl) >= 30 ml/minXx_NEWLINE_xXEstimated creatinine clearance >= 30 ml/minXx_NEWLINE_xXCalculated or measured creatinine clearance >= 30 mL/minXx_NEWLINE_xXCreatinine clearance (CrCl) < 30 ml/minXx_NEWLINE_xXPatients with creatinine clearance of less than or equal to 50 ml/minXx_NEWLINE_xXCreatinine clearance ? 30 mL/minXx_NEWLINE_xXA serum creatinine of equal or less than 2.0mg/dl or a creatinine clearance of 50 mL/min or greater on 24 hour urine collectionXx_NEWLINE_xXCreatinine value of =< 1.5 x upper limit of normal (ULN) or creatinine clearance value of >= 40 mL/minXx_NEWLINE_xXCreatinine clearance (24 hour or calculated) > 50 ml/minXx_NEWLINE_xXPatients must have creatinine of less than or equal to 1.5 mg/dL or creatinine clearance > 60 ml/minXx_NEWLINE_xXSerum creatinine of < 1.5 mg/dl or calculated creatinine clearance > 50 ml/minXx_NEWLINE_xXRenal disease, and we will use a calculated serum creatinine clearance over 30 ml/min at the screening appointment as an exclusion criteriaXx_NEWLINE_xXCreatinine =< 1.5, or creatinine clearance >= 45 mL/minXx_NEWLINE_xXknown renal insufficiency with estimated creatinine clearance (eGRF) of less than 54 mL/min;Xx_NEWLINE_xXSerum creatinine =< 2.0 mg/dl or creatinine clearance > 60 ml/min within 90 days of enrollmentXx_NEWLINE_xXCreatinine < 1.5 mg/dL or estimated creatinine clearance >= 50 mL/min/1.73 m^2Xx_NEWLINE_xXMeasured creatinine clearance more than 60 mL/min; the updated Schwartz formula should be used for pediatric patients (>= 5 to 12 years old)Xx_NEWLINE_xXEstimated creatinine clearance >= 50 cc/minXx_NEWLINE_xXCreatinine clearance >= 50 cc/minXx_NEWLINE_xXSerum creatinine (CR) < 1.5mg/dl or 24 hour CR clearance < 50 ml/minXx_NEWLINE_xXEstimated creatinine clearance >= 60 ml/minXx_NEWLINE_xXCreatinine clearance calculated >= 50 mL/minXx_NEWLINE_xXSignificant renal disease as defined by creatinine clearance less than 30 mL/minXx_NEWLINE_xXCreatinine ?2.0 mg/dL or calculated creatinine clearance ?50 mL/minXx_NEWLINE_xXCreatinine clearance or radioisotope GFR >= 60 ml/min/1.73 m^2Xx_NEWLINE_xXCreatinine clearance >= 50 cc/minXx_NEWLINE_xXCreatinine clearance < 50 ml/min (calculated or measured)Xx_NEWLINE_xXCreatinine clearance >= 30 mL/minXx_NEWLINE_xXIndividuals if creatinine clearance is < 50Xx_NEWLINE_xXCreatinine clearance (CrCl) >= 30 milliliter per minute (mL/min)Xx_NEWLINE_xXCreatinine clearance < 50 mL/min (calculated or measured)Xx_NEWLINE_xXAdequate organ system functions as defined below Absolute neutrophil count>=1.0x10^9/L, hemoglobin>=8.0 g/dL, platelet>=50x10^9/L, international normalized ration (INR) <=1.5, Partial thromboplastin time <=1.5xupper limit of normal (ULN), total bilirubin <=1.25xULN, alanine aminotransferase and aspartate aminotransferase<=1.5 X ULN, serum creatinine or calculated creatinine clearance<1.2XULN >=60 mL/min for Part 1;>=50 mL/minute (min) for Part 2 if data supports loosening criteria, Albuminuria<=500 mg/24h, left ventricular ejection fraction >=50%, Troponin<=1xULN, Calcium<=1.1xULNXx_NEWLINE_xXEstimated serum creatinine clearance of ? 50 mL/minXx_NEWLINE_xXAge-adjusted normal serum creatinine or a creatinine clearance ? 40 ml/minXx_NEWLINE_xXCalculated creatinine clearance ? 50 mL/minXx_NEWLINE_xXRenal insufficiency, preferably determined by creatinine clearance less than (<)40 milliliter per minute (mL/min) measured or estimated using the Modification of Diet in Renal Disease (MDRD), or serum creatinine >177 micromole per liter (?mol/L)Xx_NEWLINE_xXSerum creatinine < 1.5 mg/dL or creatinine clearance >= 50 mL/minXx_NEWLINE_xXPatients with impaired renal function creatinine clearance (CRCL) =< 60 mL/minXx_NEWLINE_xXWithin 14 days prior to study entry: Serum creatinine < 1.5 mg/dl OR creatinine clearance of >= 50 cc/minXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXSerum creatinine (serum or plasma) ? 1.5 x ULN or GFR>50 mL/minXx_NEWLINE_xXCreatinine > 1.5 x ULN or creatinine clearance < 60 mL/min from assays obtained < 2 weeks prior to study enrollmentXx_NEWLINE_xXPatients with a creatinine clearance less than 60Xx_NEWLINE_xXCreatinine > 1.5 x ULN or creatinine clearance < 60 mL/min, from assays obtained < 2 weeks prior to study enrollmentXx_NEWLINE_xXCreatinine >1.5 x ULN or creatinine clearance < 60 mL/minXx_NEWLINE_xXCreatinine > 1.5 x ULN or creatinine clearance < 60 mL/minXx_NEWLINE_xXSerum creatinine < 1.5 x upper limit of normal (ULN) or a calculated creatinine clearance >= 60 mL/minXx_NEWLINE_xXCreatinine > 1.5 x ULN or creatinine clearance < 60 mL/min, from assays obtained < 2 weeks prior to study enrollmentXx_NEWLINE_xXCreatinine =< 1.5 x ULN OR calculated creatinine clearance >= 50 mL/min OR 24-hour urine creatinine clearance >= 50 mL/minXx_NEWLINE_xXSevere renal impairment (i.e. creatinine clearance < 40 mL/min)Xx_NEWLINE_xXCreatinine =< 2 x ULN or creatinine clearance (CrCl) > 30 ml/minXx_NEWLINE_xXCreatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min using 24- hour urine collection for creatinine clearance, completed within 2 weeks prior to start of protocol therapyXx_NEWLINE_xXHave a calculated creatinine clearance >= 50 mL/minXx_NEWLINE_xXNORMAL VOLUNTEERS: Have a calculated creatinine clearance >= 50 ml/minXx_NEWLINE_xXSerum creatinine =< 2.0 mg/dl (calculated creatinine clearance > 45 ml/min)Xx_NEWLINE_xXSerum creatinine =< 1.5 x institutional ULN or calculated or measured 24-hour clearance >= 50 mL/minXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/minXx_NEWLINE_xXChronic or acute renal insufficiency as defined by a preoperative serum creatinine greater than 1.5 mg/dL or creatinine clearance of < 40 ml/minXx_NEWLINE_xXSerum creatinine =< 1.3 mg/dL and creatinine clearance > 50 mL/minXx_NEWLINE_xXHave adequate renal function, defined as serum creatinine levels ?2.0 ULN or calculated creatinine clearance >45 mL/min.Xx_NEWLINE_xXCreatinine =< 1.5 X ULN OR calculated creatinine clearance >= 50 mL/min OR 24-hour urine creatinine clearance >= 50 mL/minXx_NEWLINE_xXcalculated creatinine clearance > 100 mL/min/1.73 m2Xx_NEWLINE_xXserum creatinine ?1.8 mg/dL or creatinine clearance > 50 mL/min (Appendix I);Xx_NEWLINE_xXAdequate renal function (calculated creatinine clearance ? 30 mL/min)Xx_NEWLINE_xXThe participant has adequate renal function as defined by serum creatinine less than or equal to 1.5 x the institutional ULN or creatinine clearance greater than or equal to 60 mL/min for participants with creatinine levels above the ULN.Xx_NEWLINE_xXThe participant has adequate renal function as defined by serum creatinine less than or equal to 1.5 x the institutional ULN or creatinine clearance greater than or equal to 60 mL/min for participants with creatinine levels above the ULN.Xx_NEWLINE_xXEstimated creatinine clearance < 50 mL/minXx_NEWLINE_xXSerum creatinine >2.0 x ULN, or estimated creatinine clearance <40mL/minXx_NEWLINE_xXCalculated creatinine clearance >= 60 mL/minXx_NEWLINE_xX