Current uncontrolled hypertension (systolic blood pressure [BP] > 150 mmHg or diastolic pressure > 90 mmHg despite optimal medical management) as well as prior history of hypertensive crisis or hypertensive encephalopathy.Xx_NEWLINE_xXPatients with uncontrolled hypertension are ineligible; uncontrolled hypertension is defined as follows:\r\n* Patients aged =< 17 years: greater than 95th percentile systolic and diastolic blood pressure based on age and height which is not controlled by one anti-hypertensive medication\r\n* Patients aged > 17 years: systolic blood pressure >= 140 mmHg and/or diastolic blood pressure >= 90 mmHg that is not controlled by one anti-hypertensive medicationXx_NEWLINE_xXPersistent uncontrolled hypertension (systolic >160 mmHg/ diastolic >100 mmHg Exclusion Criteria Part DXx_NEWLINE_xXPatients’ baseline blood pressure must be adequately controlled with or without antihypertensive medications prior to enrollment (systolic < 140 mmHg, diastolic < 90 mmHg)Xx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure > 140 mmHg and/or diastolic blood pressure > 90 mmHg) despite antihypertensive medicationXx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure ? 200 mmHg and/or diastolic blood pressure ? 120 mmHg) on more than one occasion in the month before planned day of infusionXx_NEWLINE_xXPoorly-controlled hypertension as defined blood pressure (BP) > 150/100 mmHg, or systolic blood pressure (SBP) > 180 mmHg when diastolic blood pressure (DBP) < 90 mmHg, on at least 2 repeated determinations on separate days within 3 months prior to study enrollmentXx_NEWLINE_xXSystolic blood pressure > 160 mmHg or < 90 mmHgXx_NEWLINE_xXPatients with uncontrolled or poorly-controlled hypertension (> 160 mmHg systolic or > 100 mmHg diastolic for > 4 weeks) despite standard medical managementXx_NEWLINE_xXPatients with uncontrolled hypertension as defined as systolic blood pressure of > 140 mmHg or diastolic blood pressure of > 90 mmHg documented on 2 consecutive measurements taken at least 24 hours apart are not eligible; Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; following antihypertensive medication initiation or adjustment, blood pressure (BP) must be re-assessed three times at approximately 2-minute intervals; at least 24 hours must have elapsed between anti-hypertensive medication initiation or adjustment and BP measurement; these three values will be averaged to obtain the mean diastolic blood pressure and the mean systolic blood pressure; the mean systolic blood pressure (SBP)/diastolic blood pressure (DBP) ratio must be < 140/90 mmHg in order for a subject to be eligible for the studyXx_NEWLINE_xXUncontrolled hypertension (diastolic blood pressure > 100 mmHg; systolic blood pressure > 150 mmHg)Xx_NEWLINE_xXPatients’ baseline blood pressure must be adequately controlled with or without antihypertensive medications prior to enrollment (systolic =< 140 mmHg, diastolic =< 90 mmHg)Xx_NEWLINE_xXUncontrolled hypertension defined as persistent systolic blood pressure ? 150 mmHg or diastolic blood pressure ? 100 mmHg despite current therapy.Xx_NEWLINE_xXUncontrolled or poorly controlled hypertension (> 160 mmHg systolic or > 100 mmHg diastolic for > 4 weeks) despite standard medical managementXx_NEWLINE_xXCurrent uncontrolled hypertension (systolic blood pressure [BP] > 150 mmHg or diastolic pressure > 90 mmHg despite optimal medical management) as well as prior history of hypertensive crisis or hypertensive encephalopathy.Xx_NEWLINE_xXUncontrolled hypertension (systolic blood pressure ? 160 mmHg or diastolic blood pressure ? 95 mmHg)Xx_NEWLINE_xXUncontrolled glaucoma with intraocular pressure ? 21 mmHgXx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure > 150 mmHg and /or diastolic blood pressure > 100 mmHg)Xx_NEWLINE_xXSubject has blood pressure controlled to < 150 mmHg systolic and < 95 mmHg diastolic at screeningXx_NEWLINE_xXHypertension that is not controlled by standard medication (to 150/90 mmHg or below),Xx_NEWLINE_xXHypertension not controlled by medical therapy (resting systolic blood pressure greater than 140 mmHg or diastolic blood pressure greater than 90 mmHg on at least two occasions over a 24 hour period despite optimal medical management)Xx_NEWLINE_xXPatients with clinically significant cardiovascular disease are excluded\r\n* Inadequately controlled hypertension (HTN) (systolic blood pressure [SBP] > 160 mmHg and/or diastolic blood pressure [DBP] > 90 mmHg despite antihypertensive medication)\r\n* History of cerebrovascular accident (CVA) within 6 months\r\n* Myocardial infarction or unstable angina within 6 months\r\n* Serious and inadequately controlled cardiac arrhythmia\r\n* Significant vascular disease (e.g. aortic aneurysm, history of aortic dissection)\r\n* Clinically significant peripheral vascular diseaseXx_NEWLINE_xXEvidence of poorly controlled hypertension which is defined as systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg despite optimal medical managementXx_NEWLINE_xXUncontrolled hypertension despite appropriate medical therapy (blood pressure of greater than 160 mmHg systolic and 90 mmHg diastolic at 2 separate measurements no more than 60 minutes apart during the screening period). Note: Patients may be rescreened after adjustments of antihypertensive medicationsXx_NEWLINE_xXSubject has uncontrolled hypertension, defined as a blood pressure reading >160/100 mmHg, despite maximum antihypertensive therapy.Xx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure >= 150 mmHg and /or diastolic blood pressure >= 100 mmHg) within 7 days of first study treatmentXx_NEWLINE_xXSignificant cardiovascular disease (eg, myocardial infarction, arterial thromboembolism, cerebrovascular thromboembolism) within 3 months prior to start of study therapy; angina requiring therapy; symptomatic peripheral vascular disease; New York Heart Association Class 3 or 4 congestive heart failure; or uncontrolled Grade ?3 hypertension (diastolic blood pressure ?100 mmHg or systolic blood pressure ?160 mmHg) despite antihypertensive therapy.Xx_NEWLINE_xXUncontrolled high blood pressure (i.e. systolic blood pressure > 180 mmHg, diastolic blood pressure > 95 mmHg)Xx_NEWLINE_xXThe patient has uncontrolled or poorly controlled hypertension (> 180 mmHg systolic or > 130 mmHg diastolic) at the time of enrollmentXx_NEWLINE_xXPoorly controlled diabetes mellitus or hypertension (e.g., systolic > 180 mmHg or diastolic > 100 mmHg)Xx_NEWLINE_xXHistory or evidence of cardiovascular risk including any of the following:\r\n* A QT interval corrected for heart rate using the Bazett’s formula Bazett's correction formula (QTcB) >= 460 msec on the pre-study baseline single 12 lead EKG.\r\n* History or evidence of current clinically significant uncontrolled arrhythmias (exception: patients with controlled atrial fibrillation for > 30 days prior to registration are eligible).\r\n* History of acute coronary syndromes (including myocardial infarction and unstable angina), coronary angioplasty, or stenting within 6 months prior to registration.\r\n* History or evidence of current >= class II congestive heart failure as defined by the New York Heart Association (NYHA) functional classification system.\r\n* Treatment-refractory hypertension defined as a blood pressure of systolic > 140 mmHg and/or diastolic > 90 mmHg which cannot be controlled by anti-hypertensive therapy. In patients with no history of hypertension and a pre-study baseline blood pressure of systolic > 140 mmHg and/or diastolic > 90 mmHg, a second reading should be taken at least 1 minute later, with the two readings averaged to obtain a final blood pressure (BP) measurement.\r\n* Abnormal cardiac valve morphology (>= grade 2) documented by echocardiogram (subjects with grade 1 abnormalities [i.e., mild regurgitation/stenosis] can be entered on study). Subjects with moderate valvular thickening should not be entered on study.\r\n* Prior placement of an implantable defibrillator.\r\n* History of or identification on screening imaging of intracardiac metastases.Xx_NEWLINE_xXAny history of venous or arterial thromboembolism including deep venous thrombosis or pulmonary embolism. Patients with a history of treated prior superficial or catheter associated will not be considered as significant embolism and after discussion with principal investigator (PI) will not be excluded from eligibility. Uncontrolled hypertension (diastolic blood pressure > 90 mmHg; systolic > 140 mmHg). Patients with hypertension should be under treatment on study entry to effect blood pressure control.Xx_NEWLINE_xXPatients with a diagnosis of hypertension are required to have adequate blood pressure control prior to enrollment, defined as blood pressure =< 140/90 mmHgXx_NEWLINE_xXUncontrolled or ongoing/active infection; patients with the following history will also not be eligible for the trial: patients with a recent history of hemorrhage or hemoptysis; patients with dehiscence or wound healing complications requiring medical intervention; patients with severe hypertension that cannot be controlled (blood pressure of > 150 systolic or > 100 diastolic mmHg) with anti-hypertensive therapy within 7 days of first dose of therapyXx_NEWLINE_xX(Bevacizumab-related exclusion) Inadequately controlled hypertension (defined as systolic blood pressure >150 mmHg and/or diastolic blood pressure > 100 mmHg)Xx_NEWLINE_xXInadequately controlled hypertension (defined as persistent systolic blood pressure (SBP) > 150 and/or diastolic blood pressure (DBP) > 100 mmHg)Xx_NEWLINE_xXPoorly controlled hypertension (defined as systolic blood pressure [SBP] of > 150 mmHg or diastolic blood pressure [DBP] of > 90 mmHg)Xx_NEWLINE_xXSystolic blood pressure (SBP) >160 mmHg or <90 mmHg at screening.Xx_NEWLINE_xXUncontrolled hypertension (systolic pressure > 140 mmHg or diastolic pressure > 90 mmHg on repeated measurement) despite optimal medical managementXx_NEWLINE_xXUncontrolled hypertension (defined as systolic blood pressure > 150 mmHg and/or diastolic blood pressure > 100 mmHg)Xx_NEWLINE_xXClinically significant uncontrolled hypertension (systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg despite optimal medical management)Xx_NEWLINE_xXSupine systolic blood pressure < 90 millimeter of mercury (mmHg), or symptomatic orthostatic hypotension, defined as a decrease in systolic blood pressure upon standing of > 20 mmHg despite medical management (eg, midodrine, fludrocortisones) in the absence of volume depletionXx_NEWLINE_xXSystolic blood pressure (SBP) > 160 mmHg or < 90 mmHg at screening; if initial screening SBP is outside of the eligible range, blood pressure may be re-checked after intervention; SBP must be documented as stable and within the eligible range prior to starting study drugXx_NEWLINE_xXAs determined by the treating investigator, the patient must have well-controlled blood pressure, defined as systolic blood pressure < 150 mmHg and/or diastolic blood pressure < 100 mmHg for the majority of measurementsXx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg, despite optimal medical managementXx_NEWLINE_xXSignificant cardiovascular disease, including myocardial infarction, arterial thromboembolism, or cerebrovascular thromboembolism, within 6 months prior to start of study therapy; symptomatic dysrhythmias or unstable dysrhythmias requiring medical therapy; angina requiring therapy; symptomatic peripheral vascular disease; New York Heart Association Class 3 or 4 congestive heart failure; uncontrolled Grade ?3 hypertension (diastolic blood pressure ?100 mmHg or systolic blood pressure ?160 mmHg) despite antihypertensive therapy; or history of congenital prolonged QT syndrome.Xx_NEWLINE_xXSubjects with acute PE categorized as high-risk or massive, or who are hemodynamically unstable, evidenced by a heart rate > 120 /min and a systolic blood pressure (SBP) of < 90 mmHg for more than 15 consecutive minutes or a drop in SBP of > 40 mmHg since presentation;Xx_NEWLINE_xXPatients who have uncontrolled hypertension (defined as sustained systolic blood pressure >= 160 mmHg or diastolic >= 100 mmHg)Xx_NEWLINE_xXPatients with chronic hypertension that is well controlled with systolic blood pressure of < 140 mmHg or diastolic blood pressure of < 90 mmHg, and in whom there has been no change in blood pressure medication in the last two weeks, are eligibleXx_NEWLINE_xXPatients with uncontrolled hypertension (defined as sustained systolic blood pressure > 160 mmHg or diastolic blood pressure > 100 mmHg)Xx_NEWLINE_xXAs determined by the treating investigator, the patient must have well-controlled blood pressure, defined as systolic blood pressure < 150 mmHg and/or diastolic blood pressure < 100 mmHg for the majority of measurementsXx_NEWLINE_xXUncontrolled hypertension (defined as a sustained systolic pressure >= 160 mmHg and/or a diastolic pressure >= 110 mmHgXx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure > 150 mmHg and/or diastolic blood pressure > 100 mmHg); anti-hypertensive therapy to achieve these parameters is allowableXx_NEWLINE_xXPatients with a cumulative lifetime history of anthracycline greater than 430 mg/m^2 are eligible, after consultation with a cardiologist, if there are none of the following cardiac risk factors:\r\n*Diabetes mellitus\r\n*History of acute coronary syndrome\r\n*Hypertension; defined as a sustained systolic blood pressure greater than 140 mmHg and/or diastolic blood pressure greater than 90 mmHg OR use of an antihypertensive medication for the indication of hypertensionXx_NEWLINE_xXUncontrolled hypertension (blood pressure >= 150/90 mmHg despite optimal medical management)Xx_NEWLINE_xXUncontrolled arterial hypertension defined by blood pressure > 150 mmHg systolic and/or 100 mmHg diastolic at rest (average 3 consecutive readings at least 5 minutes apart) despite appropriate medical therapyXx_NEWLINE_xXCAPMATINIB EXCLUSION CRITERIA: Cardiovascular disorders including:\r\n* Symptomatic congestive heart failure (New York Heart Association class III or IV)\r\n* Personal or family history of congenital long QT syndrome\r\n* Corrected QTc > 480 msec using Fridericia correction on screening electrocardiography (ECG)\r\n* Uncontrolled hypertension (systolic pressure >= 160 mmHg or diastolic pressure >= 100 mmHg on repeated measurement) despite optimal medical management; initiation or adjustment of anti-hypertensive medications are allowed prior to screeningXx_NEWLINE_xXCERITINIB EXCLUSION CRITERIA: Cardiovascular disorders including:\r\n* Symptomatic congestive heart failure (New York Heart Association class III or IV)\r\n* Personal or family history of congenital long QT syndrome\r\n* Corrected QTc > 480 msec using Fridericia correction on screening electrocardiography (ECG)\r\n* Uncontrolled hypertension (systolic pressure > 140 mmHg or diastolic pressure > 90 mmHg on repeated measurement) despite optimal medical managementXx_NEWLINE_xXREGORAFENIB EXCLUSION CRITERIA: Cardiovascular disorders including:\r\n* Symptomatic congestive heart failure (New York Heart Association class III or IV)\r\n* Personal or family history of congenital long QT syndrome\r\n* Corrected QTc > 480 msec using Fridericia correction on screening electrocardiography (ECG)\r\n* Uncontrolled hypertension (systolic pressure > 140 mmHg or diastolic pressure > 90 mmHg on repeated measurement) despite optimal medical managementXx_NEWLINE_xXENTRECTINIB EXCLUSION CRITERIA: Cardiovascular disorders including:\r\n* Symptomatic congestive heart failure (New York Heart Association class III or IV)\r\n* Personal or family history of congenital long QT syndrome\r\n* Corrected QTc > 480 msec using Fridericia correction on screening electrocardiography (ECG)\r\n* Uncontrolled hypertension (systolic pressure > 140 mmHg or diastolic pressure > 90 mmHg on repeated measurement) despite optimal medical managementXx_NEWLINE_xXUncontrolled hypertension, defined as: systolic blood pressure ? 140 mmHg and/or diastolic blood pressure ? 90 mmHg;Xx_NEWLINE_xXThe patient has uncontrolled or poorly-controlled hypertension (> 160 mmHg systolic or > 100 mmHg diastolic for > 4 weeks) despite standard medical managementXx_NEWLINE_xXPatients must not have uncontrolled hypertension as defined by systolic blood pressure (SBP) >= 160 mmHg or diastolic blood pressure (DBP) >= 90 mmHg; patients whose blood pressure can be controlled medically are allowed to be rescreened once blood pressure (BP) is under controlXx_NEWLINE_xXHypertension not controlled by medical therapy (systolic blood pressure greater than 140 millimeter of mercury [mmHg] or diastolic blood pressure greater than 90 mmHg)Xx_NEWLINE_xXPHASE I STUDY ELIGIBILITY CRITERIA:\r\nAdequately controlled blood pressure (systolic blood pressure [SBP] < 140 mmHg and diastolic blood pressure [DBP] < 90 mmHg) on a maximum of three antihypertensive medicationsXx_NEWLINE_xXSubject currently exhibits symptomatic or persistent, uncontrolled hypertension defined as diastolic blood pressure > 90 mmHg or systolic blood pressure > 140 mmHg; subjects may be re-screened if blood pressure is shown to be controlled with or without interventionXx_NEWLINE_xXPatients who have uncontrolled hypertension (defined as sustained systolic blood pressure >= 160 mmHg or diastolic >= 100 mmHg)Xx_NEWLINE_xXUncontrolled hypertension despite appropriate medical therapy (blood pressure of greater than 160 mmHg systolic and 90 mmHg diastolic at 2 separate measurements no more than 60 minutes apart during the screening period); Note: patients may be rescreened after adjustments of antihypertensive medicationsXx_NEWLINE_xXPatients who have uncontrolled hypertension (systolic > 140 mmHg and/or diastolic > 90 mmHg); it is permissible to start treatment for hypertension prior to randomizationXx_NEWLINE_xXPoorly controlled hypertension (defined as systolic blood pressure of >= 160 mmHg or diastolic blood pressure of >= 90 mmHg); Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; following antihypertensive medication initiation or adjustment, blood pressure must be reassessed three times at approximately 2-minute intervals; at least 24 hours must have elapsed between antihypertensive medication initiation or adjustment and blood pressure measurement; these three values should be averaged to obtain the mean diastolic and systolic blood pressures, which must be < 140/90 mmHg in order for a patient to be eligible for the studyXx_NEWLINE_xXHistory of uncontrolled hypertension, defined as blood pressure > 150/95 mmHg, or systolic blood pressure > 180 mmHg when diastolic blood pressure < 90 mmHg, on at least 2 repeated determinations on separate days within 3 months prior to study enrollmentXx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure > 140 mmHg and/or diastolic blood pressure > 90 mmHg)Xx_NEWLINE_xXSystolic blood pressure greater than 150 mmHg or diastolic blood pressure greater than 100 mmHgXx_NEWLINE_xXInadequately controlled hypertension (blood pressure: systolic > 150 mmHg and/or diastolic > 100 mmHg)Xx_NEWLINE_xXUncontrolled systemic vascular hypertension (systolic blood pressure > 140 mmHg, diastolic blood pressure > 90 mmHg on medication)Xx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure > 140 mmHg or diastolic pressure > 90 mmHg, despite optimal medical managementXx_NEWLINE_xXPatients with clinically significant cardiovascular disease are excluded\r\n* Inadequately controlled hypertension (HTN) (systolic blood pressure [SBP] > 160 mmHg and/or diastolic blood pressure [DBP] > 90 mmHg despite antihypertensive medication)\r\n* History of cerebrovascular accident (CVA) within 6 months (see additional requirement for adjuvant protocols)\r\n* Myocardial infarction or unstable angina within 6 months (see additional requirement for adjuvant protocols)\r\n* New York Heart Association grade II or greater congestive heart failure \r\n* Serious and inadequately controlled cardiac arrhythmia\r\n* Significant vascular disease (e.g. aortic aneurysm, history of aortic dissection)\r\n* Clinically significant peripheral vascular diseaseXx_NEWLINE_xXUncontrolled hypertension as indicated by at least 2 consecutive measurements of a resting systolic blood pressure > 170 mmHg or diastolic blood pressure > 105 mmHg at the Screening VisitXx_NEWLINE_xXUncontrolled or poorly-controlled hypertension (> 160 mmHg systolic or > 100 mmHg diastolic for > 4 weeks) despite standard medical managementXx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure > 140 mmHg and/or diastolic blood pressure > 90 mmHg); to control hypertension, the addition or increase of standard of care antihypertensive regimen is allowedXx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure > 140 mmHg and/or diastolic blood pressure > 90 mmHg) despite antihypertensive medication, or prior history of hypertensive crisis or hypertensive encephalopathyXx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure > 140 and/or diastolic blood pressure > 90 mmHg); initiation of antihypertensive is permitted provided adequate control is documented over at least 1 week prior to day 1 of study drugXx_NEWLINE_xXSupine systolic blood pressure < 100 mmHg or supine diastolic blood pressure < 50 mmHg at screening and baselineXx_NEWLINE_xXUncontrolled hypertension (untreated systolic blood pressure > 160 mmHg, or diastolic blood pressure > 95 mmHg)Xx_NEWLINE_xXA common skin contaminant cultured from 2 or more blood cultures drawn on the same or consecutive calendar days from a subject with fever (greater than 38.0 degrees C), chills, or hypotension (systolic blood pressure less than 90 mmHg);Xx_NEWLINE_xXUncontrolled hypertension on anti-hypertensive medication (systolic blood pressure >150 mmHg or diastolic blood pressure >95 mmHg)Xx_NEWLINE_xXBlood pressure < 160/100 mmHgXx_NEWLINE_xXInadequately controlled hypertension (systolic blood pressure of > 150 mmHg or diastolic pressure > 90 mmHg on anti-hypertensive medications)Xx_NEWLINE_xXEvidence of severe or uncontrolled systemic diseases (e.g., unstable or uncompensated respiratory, hepatic, renal, cardiac disease, or clinically significant bleeding episodes). Any serious and/or unstable pre-existing medical (aside from malignancy), psychiatric disorder, or other conditions that could interfere with subject's safety, obtaining informed consent or compliance to the study procedures, in the opinion of the Investigator; systolic blood pressure higher than 150 millimeter of mercury (mmHg) or diastolic blood pressure higher than 90 mmHg found on 2 separate occasions separated by 1 week, despite adequate therapy, will be defined as uncontrolled hypertension; uncontrolled diabetes mellitus (despite therapeutic, compliance intervention) as defined by a hemoglobin A1c (HbA1c) level more than 8% and/or occurrence of more than 2 episodes of ketoacidosis in the 12 months prior to the first dose of study drug.Xx_NEWLINE_xXPatients with systolic blood pressure (SBP) >= 140 mmHg or diastolic blood pressure (DBP) >= 90 mmHg at the screening visit are ineligible; patients with an initial clinic blood pressure (BP) >= 140/90 mmHg may be included if SBP < 140 mmHg and DBP < 90 mmHg is confirmed in two subsequent BP measurements on the same dayXx_NEWLINE_xXHypertension that is not controlled by standard medication (to 150/90 mmHg or below)Xx_NEWLINE_xXUncontrolled arterial hypertension defined as persistent elevation of systolic blood pressure >= 150 mmHg or diastolic blood pressure >= 100 mmHg despite medical treatmentXx_NEWLINE_xXPatients with hypertension on medical management must have systolic blood pressure < 150 mmHG or diastolic pressure < 90 mmHG at study entryXx_NEWLINE_xXUncontrolled hypertension (defined as a systolic pressure ? 160 mmHg and/or a diastolic pressure ? 110 mmHg).Xx_NEWLINE_xXHypertension not controlled by medical therapy (systolic blood pressure [BP] greater than 160 millimeters of mercury [mmHg] or diastolic blood pressure great than 100 mmHg)Xx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure >140 mmHg and/or diastolic blood pressure > 90 mmHg)Xx_NEWLINE_xXPoorly controlled hypertension (defined as systolic blood pressure [SBP] of >= 150 mmHg and/or diastolic blood pressure [DBP] of >= 90 mmHg); Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study registrationXx_NEWLINE_xXSystolic blood pressure < 90 mmHg and/or diastolic blood pressure < 50 mmHgXx_NEWLINE_xXSubjects who have a history or current evidence of uncontrolled hypertension defined as systolic blood pressure > 150 mmHg or diastolic blood pressure > 95 mmHg at screening despite optimal medical management; subjects with a history of mild to moderate hypertension are eligible at the investigator’s discretion if the hypertension is adequately controlled by antihypertensive treatment used at a stable dose for at least 2 weeks before the start of study treatmentXx_NEWLINE_xXUncontrolled high blood pressure (i.e., systolic blood pressure >= 160 mmHg, diastolic blood pressure >= 90 mmHg)Xx_NEWLINE_xXHemodynamic parameters:\r\n* Systolic blood pressure < 140 mmHg\r\n* Diastolic blood pressure < 90 mmHgXx_NEWLINE_xXFor patients receiving antihypertensive medication:systolic blood pressure < 120 mmHg\n             and/or diastolic blood pressure < 70 mmHg at screening.Xx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure > 150 and/or diastolic blood pressure > 100 mmHg on antihypertensive medications)Xx_NEWLINE_xXUncontrolled hypertension, defined as systolic blood pressure > 140 mmHg or diastolic pressure > 90 mmHg, despite optimal medical managementXx_NEWLINE_xXPatients must have blood pressure measured within 14 days prior to registration; patients must not have uncontrolled hypertension (defined as blood pressure > 160 mmHg systolic and > 90 mmHg diastolic at 2 separate measurements no more than 60 minutes apart) despite appropriate medical therapy; Note: patients may be rescreened after adjustments of antihypertensive medicationsXx_NEWLINE_xXNo uncontrolled or poorly controlled hypertension despite standard medical management(e.g., consistently systolic blood pressure [SBP] > 160 and diastolic blood pressure [DBP] > 90 mmHg)Xx_NEWLINE_xXUncontrolled hypertension with systolic blood pressure >160 mmHgXx_NEWLINE_xXFor Cohort C: Has hypotension (systolic blood pressure <86 millimeters of mercury [mmHg]) or uncontrolled hypertension (systolic blood pressure >170 mmHg or diastolic blood pressure >105 mmHg) at the screening visitXx_NEWLINE_xXPoorly controlled hypertension (defined as systolic blood pressure [systolic blood pressure (SBP) of >= 150 mmHg or diastolic blood pressure (DBP)] of >= 90 mmHg)Xx_NEWLINE_xXPatients who have uncontrolled or poorly-controlled hypertension (> 139 mmHg systolic or > 89 mmHg diastolic for > 4 weeks) despite standard medical managementXx_NEWLINE_xXPatient must have a systolic blood pressure =< 140 mmHg and diastolic blood pressure must be =< 90 mmHg, measured within 4 weeks prior to randomization; initiation or adjustment of anti-hypertensives prior to starting study treatment is allowedXx_NEWLINE_xXPoorly controlled hypertension, defined as systolic blood pressure (SBP) of >= 140 mmHg or diastolic blood pressure (DBP) of >= 90mmHg; Note: screening/baseline blood pressure (BP) must be assessed with three measurements at approximately 2-minute intervals; the mean SBP/DBP values from the three readings must be < 140/90 mmHg in order for a subject to be eligible for the study; if the subject’s initial screening SBP/DBP is >= 140/90 mmHg, initiation or adjustment of antihypertensive medication(s) is permitted in an attempt to control the subject’s BP level to below 140/90 mmHg; optimal blood pressure control must be achieved before registration and monitoredXx_NEWLINE_xXPoorly controlled hypertension (defined as systolic blood pressure of >= 140 mmHg or diastolic blood pressure of >= 90 mmHg); Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; following antihypertensive medication initiation or adjustment, blood pressure must be reassessed three times at approximately 2-minute intervals; at least 24 hours must have elapsed between antihypertensive medication initiation or adjustment and blood pressure measurement; these three values should be averaged to obtain the mean diastolic and systolic blood pressures, which must be < 140/90 mmHg in order for a patient to be eligible for the studyXx_NEWLINE_xXPatients are ineligible if they have inadequately controlled hypertension (defined as systolic blood pressure > 150 and/or diastolic blood pressure > 100 mmHg on antihypertensive medications)Xx_NEWLINE_xXUncontrolled blood pressure (systolic pressure greater than 150 mmHg or diastolic pressure greater than 90 mmHg on repeated measurements).Xx_NEWLINE_xXSubjects with a blood pressure of >140/90 mmHg.Xx_NEWLINE_xXUncontrolled hypertension (defined as a systolic pressure ? 160 mmHg and/or a diastolic pressure ? 110 mmHg).Xx_NEWLINE_xXSystolic Blood Pressure (SBP) >160 or <90 mmHgXx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg, despite optimal medical managementXx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure > 150 mmHg and/or diastolic blood pressure > 100 mmHg); anti-hypertensive therapy to maintain a systolic blood pressure < 150 mmHg and/or diastolic blood pressure < 100 mmHg is permittedXx_NEWLINE_xXUncontrolled arterial hypertension (systolic blood pressure > 155 mmHg or diastolic > 95 mmHg) despite appropriate medical therapyXx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg, despite optimal medical managementXx_NEWLINE_xXTreatment refractory hypertension defined as a blood pressure of systolic >140 millimeter of mercury (mmHg) and/or diastolic >90 mmHg which cannot be controlled by antihypertensive therapy.Xx_NEWLINE_xXPatients with pre-existing hypertension should be on a stable antihypertensive regimen and have a blood pressure =< 150/100 mmHg at the time of enrollmentXx_NEWLINE_xXUncontrolled arterial hypertension defined as persistent elevation of systolic blood pressure >= 150 mmHg or diastolic blood pressure >= 100 mmHg despite current therapyXx_NEWLINE_xXPatients with clinically significant cardiovascular disease are excluded\r\n* Inadequately controlled hypertension (HTN) (systolic blood pressure [SBP] >= 160 mmHg and/or diastolic blood pressure [DBP] >= 90 mmHg despite antihypertensive medication)\r\n* History of cerebrovascular accident (CVA) within 6 months\r\n* Myocardial infarction or unstable angina within 6 months\r\n* New York Heart Association class II or greater congestive heart failure \r\n* Serious and inadequately controlled cardiac arrhythmia\r\n* Significant vascular disease (e.g. aortic aneurysm, history of aortic dissection)\r\n* Clinically significant peripheral vascular diseaseXx_NEWLINE_xXInadequately controlled hypertension (defined as average systolic blood pressure > 150 mmHg and/or diastolic blood pressure > 100 mmHg)Xx_NEWLINE_xXHave uncontrolled hypertension, as defined in CTCAE Version 4.0, prior to initiating study treatment, despite antihypertensive intervention. CTCAE Version 4.0 defines uncontrolled hypertension as Grade >2 hypertension; clinically, the participant continues to experience elevated blood pressure (systolic >160 millimeters of mercury [mmHg] and/or diastolic >100 mmHg) despite medications.Xx_NEWLINE_xXUncontrolled hypertension (systolic pressure > 140 mmHg or diastolic pressure > 90 mmHg [NCI-CTCAE v4.0] on repeated measurement) despite optimal medical managementXx_NEWLINE_xXUncontrolled hypertension – blood pressure >= 150/90 mmHg despite medical therapyXx_NEWLINE_xXSubjects who have a history or current evidence of uncontrolled hypertension defined as systolic blood pressure ?160 mmHg or diastolic blood pressure ?100 mmHg at screening despite optimal medical management.Xx_NEWLINE_xXHypotension as indicated by systolic blood pressure < 86 mmHg on 2 consecutive measurements at the Screening visit.Xx_NEWLINE_xXUncontrolled hypertension as indicated by systolic blood pressure > 170 mmHg or diastolic blood pressure > 105 mmHg on 2 consecutive measurements at the Screening visit.Xx_NEWLINE_xXPatients who have uncontrolled hypertension (defined as sustained systolic blood pressure >= 160 mmHg or diastolic >= 100 mmHg)Xx_NEWLINE_xXSystolic blood pressure greater than 160 mmHg or less than 90 mmHg at screeningXx_NEWLINE_xXUncontrolled hypertension; (systolic blood pressure > 140 mmHg or diastolic pressure > 90 mmHg despite optimal medical management)Xx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure >150 mmHg or diastolic blood pressure >90 mmHg, despite optimal medical management.Xx_NEWLINE_xXUncontrolled hypertension (blood pressure >160 mmHg systolic and >100 mmHg diastolic).Xx_NEWLINE_xXPatient with impaired cardiac function or any clinically significant uncontrolled cardiac disease, and/or, cardiac repolarization abnormality, including any of the following: Clinically significant heart disease such as CHF requiring treatment (NYH grade ? 2), history of angina pectoris, myocardial infarction, symptomatic pericarditis, or coronary artery bypass graft (CABG) within 6 months prior to study entry, documented cardiomyopathy, or left ventricular ejection fraction (LVEF) < 50% as determined by multiple gated acquisition scan (MUGA) or echocardiogram (ECHO). Uncontrolled systolic blood pressure (SBP) ?160 mmHg and/or diastolic blood pressure (DBP) ?100 mmHg, with or without anti-hypertensive medication. Initiation or adjustment of antihypertensive medication (s) is allowed prior to screening, Systolic blood pressure (SBP) <90 mmHg Standard 12-lead ECG values defined as the mean of the triplicate ECGs and assessed by central laboratoryXx_NEWLINE_xXControlled blood pressure defined as a systolic blood pressure =< 140 mmHg and diastolic blood pressure =< 90 mmHg on no more than three anti-hypertensive agents; drug formulations containing two or more anti-hypertensive agents will be counted based on the number of active agents in each formulationXx_NEWLINE_xXPatients with uncontrolled hypotension (systolic blood pressure < 90 mmHg and/or diastolic blood pressure < 50 mmHg)Xx_NEWLINE_xXHypertension as defined by systolic blood pressure > 140 mmHg or diastolic blood pressure > 90 mmHg despite optimal medical managementXx_NEWLINE_xXPatients with poorly controlled hypertension (systolic blood pressure of 140 mmHg or higher or diastolic blood pressure of 90 mmHg or higher) are ineligible; patients with a history of hypertension (HTN) and stable blood pressure (BP) < 140/90 on anti-HTN regimen are eligibleXx_NEWLINE_xXInadequately controlled hypertension (i.e., systolic blood pressure >160 mmHg or diastolic blood pressure >100 mmHg) (patients with values above these levels must have their blood pressure controlled with medication prior to starting treatment).Xx_NEWLINE_xXUncontrolled systemic vascular hypertension (systolic blood pressure > 140 mmHg, diastolic blood pressure > 90 mmHg on medication)Xx_NEWLINE_xXSignificant active cardiovascular disease including:\r\n* Uncontrolled high blood pressure (i.e., systolic blood pressure > 180 mmHg, diastolic blood pressure > 95 mmHg)\r\n* Grade 3 or higher valvular disease\r\n* Grade 3 or higher atrial fibrillation\r\n* Grade 3 or higher bradycardia\r\n* Endocarditis\r\n* Pulmonary embolism\r\n* Recent cerebrovascular accident within 6 months prior to enrollmentXx_NEWLINE_xXNo patients with inadequately controlled hypertension (defined as a blood pressure of >= 150 mmHg systolic and/or >= 90 mmHg diastolic), or any prior history of hypertensive crisis or hypertensive encephalopathyXx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg, despite optimal medical managementXx_NEWLINE_xXDiastolic blood pressure above the 95% for age in children and > 160 mmHg systolic or > 100 mmHg diastolic in adults on at least 2 of 3 measurements with an appropriate-size cuff who are unable to achieve blood pressure control with optimal anti-hypertensive therapy; patients who are treated with antihypertensive medications with good response are eligibleXx_NEWLINE_xXKnown impaired cardiac function or clinically significant cardiac disease such as ventricular arrhythmia requiring therapy, congestive heart failure and uncontrolled hypertension (defined as systolic blood pressure >150 mmHg and/or diastolic blood pressure > 100 mmHg on antihypertensive medications).Xx_NEWLINE_xXSubject has uncontrolled hypertension as indicated by a resting systolic blood pressure > 160 millimeter of mercury (mmHg) or diastolic blood pressure > 100 millimeter of mercury (mmHg) at Screening.Xx_NEWLINE_xXUnstable hypertension defined as a systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg despite optimal medical managementXx_NEWLINE_xXPatients must have controlled blood pressure with a systolic blood pressure < 140 mmHg and diastolic < 90 mmHg; anti-hypertensive medications are permittedXx_NEWLINE_xXBlood pressure well controlled and must have systolic < 140 mmHg and diastolic < 90 mmHgXx_NEWLINE_xXSystolic blood pressure >160 or <90 mmHgXx_NEWLINE_xXHas existing uncontrolled arterial hypertension (systolic blood pressure [SBP] ?150 mmHg or diastolic blood pressure [DBP] ?100 mmHg) despite appropriate medical therapyXx_NEWLINE_xXPatients with inadequately controlled hypertension (defined as systolic blood pressure > 150 and/or diastolic blood pressure > 100 mmHg) are not eligible for participationXx_NEWLINE_xXUncontrolled hypertension (systolic pressure > 140 mmHg or diastolic pressure > 90 mmHg (National Cancer Institute Common Terminology Criteria for Adverse Events [NCI-CTCAE] version [v]4.0) on repeated measurement) despite optimal medical managementXx_NEWLINE_xXPatients with a history of hypertension should be well controlled (< 140/90 mmHg) on a regimen of anti-hypertensive therapyXx_NEWLINE_xXPoorly controlled hypertension, defined as systolic blood pressure >= 150 mmHg or diastolic blood pressure of >= 95 mmHgXx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg, despite optimal medical managementXx_NEWLINE_xXUncontrolled hypertension (systolic blood pressure [BP] > 150 mmHg or diastolic pressure > 90 mmHg despite optimal medical management).Xx_NEWLINE_xXClinically significant cardiovascular disease, such as:\r\n* Inadequately controlled hypertension (HTN) (for adults: systolic blood pressure [SBP] > 160 mmHg and/or diastolic blood pressure [DBP] > 90 mmHg despite antihypertensive medication; for children: please refer to \Grading and management of hypertension for adults and for children 6 through 17 years old\ for age-appropriate values indicating >= grade 2)\r\n* History of cerebrovascular accident (CVA) within 12 months\r\n* Myocardial infarction or unstable angina within 12 months\r\n* New York heart association grade II or greater congestive heart failure\r\n* Serious and inadequately controlled cardiac arrhythmia\r\n* Significant vascular disease (e.g., aortic aneurysm, history of aortic dissection)\r\n* Clinically significant peripheral vascular diseaseXx_NEWLINE_xXPatient must not have poorly controlled hypertension (defined as systolic blood pressure of >= 140 mmHg or diastolic blood pressure of >= 90 mmHg); initiation or adjustment of antihypertensive medications is permitted prior to study entry; blood pressure must be re-assessed on two occasions that are separated by a minimum of one hour; on each of these occasions, the mean (of 3 readings) from each assessment must be < 140/90 mmHg for a patient to be eligible for this studyXx_NEWLINE_xXClinically significant cardiovascular disease including myocardial infarction within 6 months, uncontrolled angina within 3 months, congestive heart failure New York Heart Association (NYHA) class 3 or 4, uncontrolled hypertension as indicated by systolic blood pressure > 160 mmHg or diastolic blood pressure > 95 mmHg at the screening visitXx_NEWLINE_xXGenerally well-controlled blood pressure with systolic blood pressure =< 140 mmHg AND diastolic blood pressure =< 90 mmHg prior to enrollment; the use of anti-hypertensive medications to control hypertension is permittedXx_NEWLINE_xXUncontrolled hypertension (blood pressure ? 150/90 mmHg despite optimal medical management)Xx_NEWLINE_xXVital signs within the ranges: systolic blood pressure 80-150 mmHg , diastolic blood pressure 50-100 mmHg, pulse rate 40-100 bpm, oral body temperature 35.0-37.5°C.Xx_NEWLINE_xXPatients with poorly controlled hypertension (systolic blood pressure of 140 mmHg or higher or diastolic blood pressure of 91 mmHg or higher) are ineligibleXx_NEWLINE_xXHistory or evidence of cardiovascular risk (LVEF < LLN; QTcB >= 480 msec; blood pressure or systolic >=140 mmHg or diastolic >= 90 mmHg which cannot be controlled by anti-hypertensive therapy)Xx_NEWLINE_xXInadequately controlled hypertension (systolic blood pressure of > 150 mmHg or diastolic pressure > 100 mmHg on anti-hypertensive medications); Note: history of hypertensive crisis or hypertensive encephalopathy not allowedXx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure > 150 mmHg and/or diastolic blood pressure > 100 mmHg)Xx_NEWLINE_xXSystolic blood pressure (SBP) > 110 mmHg; diastolic blood pressure (DBP) >= 60 mmHgXx_NEWLINE_xXUncontrolled hypertension (systolic blood pressure [sBP] > 150 mmHg and/or diastolic BP > 100 mmHg, found on two consecutive measurements separated by a one week period of time despite adequate medical support)Xx_NEWLINE_xXPatients’ baseline blood pressure must be adequately controlled with or without antihypertensive medications prior to enrollment (systolic < 145 mmHg, diastolic < 90 mmHg)Xx_NEWLINE_xXPoorly controlled hypertension (defined as systolic blood pressure [SBP] of >= 140 mmHg or diastolic blood pressure [DBP] of >= 90mmHg); Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; blood pressure must be re-assessed prior to start of study therapy; the mean SBP/DBP values must be < 140/90 mmHg (OR 150/90 mmHg, if this criterion is approved by Safety Review Team) in order for a subject to be eligible for the studyXx_NEWLINE_xXPatients with inadequately controlled hypertension (defined as a blood pressure of > 150 mmHg systolic and/or > 100 mmHg diastolic on medication), or any prior history of hypertensive crisis or hypertensive encephalopathyXx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure > 150 mmHg and/or diastolic blood pressure > 100 mmHg)Xx_NEWLINE_xXInadequately controlled hypertension (i.e. systolic blood pressure [SBP] > 180 mmHg or diastolic blood pressure [DBP] > 100 mmHg)Xx_NEWLINE_xXUncontrolled systemic vascular hypertension (systolic blood pressure > 140 mmHg, diastolic blood pressure > 90 mmHg on medication)Xx_NEWLINE_xXPoorly controlled hypertension (defined as systolic blood pressure [SBP] of >= 140 mmHg or diastolic blood pressure [DBP] of >= 90mmHg); initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; blood pressure must be re-assessed on two occasions that are separated by a minimum of 24 hours; the mean SBP/DBP values from each blood pressure assessment must be < 140/90 mmHg in order for a subject to be eligible for the studyXx_NEWLINE_xXEXPANSION COHORT ONLY: Poorly controlled hypertension (defined as systolic blood pressure [SBP] of >= 140 mmHg or diastolic blood pressure [DBP] of >= 90mmHg); initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; blood pressure must be re-assessed on two occasions that are separated by a minimum of 24 hours; the mean SBP/DBP values from each blood pressure assessment must be < 140/90 mmHg in order for a subject to be eligible for the studyXx_NEWLINE_xXBlood pressure of > 150/100 mmHg, history of hypertensive crisis or hypertensive encephalopathyXx_NEWLINE_xXUncontrolled systemic vascular hypertension (systolic blood pressure > 140 mmHg, diastolic blood pressure > 90 mmHg on medication)Xx_NEWLINE_xXSystolic blood pressure > 160 mmHg or diastolic pressure > 90 mmHg despite optimal medical managementXx_NEWLINE_xXAdult patients with hypertension not controlled by medical therapy (hypertension defined as systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg despite optimal medical management); pediatric patients must have blood pressure (BP) within normal limits (WNL) for age; NOTE: blood pressure within the upper limit of normal is defined as: blood pressure =< the 95th percentile for age, height, and gender, and not be receiving medication for treatment of hypertensionXx_NEWLINE_xXControlled blood pressure (defined as systolic BP </= 140 mmHg and diastolic </= 85 mmHg)Xx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure > 140 mmHg or diastolic pressure > 85 mmHg despite optimal medical managementXx_NEWLINE_xXSubject has severe or uncontrolled systemic diseases including uncontrolled hypertension (blood pressure > 150/100 mmHg) or active bleeding diatheses.Xx_NEWLINE_xXSystolic blood pressure 80-180 mmHgXx_NEWLINE_xXSignificant uncontrolled pulmonary hypertension defined as: Pulmonary artery peak systolic pressure > 55 mmHg by echocardiogram, or pulmonary artery peak systolic pressure 45-55 mmHg by echocardiogram and mean pulmonary artery pressure by right heart catheterization exceeding 25 mmHg at rest (or 30 mmHg with exercise); or NYHA/World Health Organization (WHO), Class III or IVXx_NEWLINE_xXUncontrolled hypertension (blood pressure greater than 140/90 mmHg on at least 2 measurements on sequential visits, despite blood pressure medication)Xx_NEWLINE_xXHypertension, defined for adults by SBP ? 160 mmHg and/or DBP ? 100 mmHg at baseline (or screening if baseline visit is skipped), and for pediatric patients by blood pressure greater than the 95th percentile for age, sex, and height (see Table 16-1). Additionally, patients who were started on antihypertensive medication after HSCT or who have received additional antihypertensive medication after HSCT will be eligible, even if they don't have elevated blood pressure.Xx_NEWLINE_xXSeated systolic blood pressure 90 to 180 mmHgXx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure ?160 mmHg and/or diastolic blood pressure ?100 mmHg confirmed upon repeated measuresXx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure ? 160 mmHg and/or diastolic blood pressure ? 100 mmHg confirmed upon repeated measuresXx_NEWLINE_xXUncontrolled hypertension as indicated by at least 2 consecutive measurements of a resting systolic blood pressure > 170 mmHg or diastolic blood pressure > 105 mmHg at the screening visit.Xx_NEWLINE_xXUncontrolled hypertension defined as systolic pressure > 140 mmHg or diastolic pressure > 90 mmHg despite optimal medical managementXx_NEWLINE_xXSupine systolic blood pressure < 100 mmHg or diastolic blood pressure < 50 mmHg.Xx_NEWLINE_xXPatients must have blood pressure no greater than 140 mmHg (systolic blood pressure) and 90 mmHg (diastolic blood pressure) for eligibility; initiation or adjustment of antihypertensive medications is permitted prior to study entry provided that the average of three blood pressure measurements at enrollment visit is less than 140/90 mmHgXx_NEWLINE_xXBlood pressure ? 140/90 mmHg.Xx_NEWLINE_xXPoorly controlled hypertension (defined as systolic blood pressure [SBP] of ? 150 mmHg or diastolic blood pressure [DBP] of ? 90 mmHg) on more than one occasionXx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure >140 mmHg and/or diastolic blood pressure > 90 mmHg)Xx_NEWLINE_xXHave uncontrolled hypertension (systolic blood pressure [SBP] greater than140 mmHg or diastolic blood pressure [DBP] greater than 90 mmHg) despite optimal medical management.Xx_NEWLINE_xXHypotension at the time of screening (i.e., systolic blood pressure less than 110 mmHg. Diastolic blood pressure less than 60 mmHg)Xx_NEWLINE_xXPoorly controlled hypertension [defined as systolic blood pressure (SBP) of ? 140 mmHg or diastolic blood pressure (DBP) of ? 90mmHg].Xx_NEWLINE_xXConfirmed systolic blood pressure < 100 mmHg or diastolic blood pressure < 50 mmHgXx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg, despite optimal medical managementXx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure >150 mmHg or diastolic blood pressure >90 mmHg, despite optimal medical managementXx_NEWLINE_xXIntraocular pressure > 21 mmHg as measured by tonometryXx_NEWLINE_xXHistory of uncontrolled hypertension (systolic > 150 mmHg or diastolic pressure > 90 mmHg) despite optimal medical managementXx_NEWLINE_xX6. Uncontrolled hypertension (diastolic ? 100 mmHg) or hypotension (systolic ? 90 mmHg).Xx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure >160 mmHg or diastolic blood pressure >100 mmHg, despite optimal medical management and stable antihypertensive treatment for more than 7 days before the first dose of study drugXx_NEWLINE_xXSubjects with uncontrolled hypertension (systolic blood pressure >180 mmHg or diastolic blood pressure >100 mmHg) are excluded. Subjects requiring 2 or more medications to control hypertension are eligible with Medical Monitor approval.Xx_NEWLINE_xXSignificant cardiovascular disease including unstable angina pectoris, uncontrolled hypertension (persistent systolic blood pressure > 150 mmHg and/or diastolic blood pressure > 100 mmHg on antihypertensive medications) or arrhythmia, congestive heart failure (NYHA Class III or IV) related to primary cardiac disease, ischemic or severe valvular heart disease, or myocardial infarction within 6 months prior to the first dose of study treatmentXx_NEWLINE_xXUncontrolled high blood pressure (that is, systolic blood pressure >180 millimeter of mercury [mmHg], diastolic blood pressure >95 mmHg).Xx_NEWLINE_xXUncontrolled hypertension, defined as SBP ? 140 mmHg and/or DBP ? 90 mmHg with optimized anti-hypertensive therapyXx_NEWLINE_xXHistory of uncontrolled hypertension, defined as systolic blood pressure > 150 mmHg while simultaneous diastolic blood pressure > 100 mmHg, or systolic blood pressure > 180 mmHg when diastolic blood pressure < 90 mmHg, on at least 2 repeated determinations on separate days within 3 months prior to study enrollmentXx_NEWLINE_xXUncontrolled hypertension: systolic blood pressure of > 140 mmHg or diastolic blood pressure of > 90 mmHg documented on 2 consecutive measurements taken at least 24 hours apartXx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure >150 mmHg or diastolic blood pressure >90 mmHg on 2 or more consecutive blood pressure readings, despite optimal medical managementXx_NEWLINE_xXUncontrolled hypertension (diastolic greater to or equal to 100 mmHg) or hypotension (systolic less than or equal to 90 mmHg)Xx_NEWLINE_xXTreatment refractory hypertension defined as systolic blood pressure >140 millimetres of mercury (mmHg) and/or diastolic blood pressure >90 mmHg which cannot be controlled by antihypertensive therapyXx_NEWLINE_xXUncontrolled hypertension as indicated by a resting systolic blood pressure >170 mmHg or diastolic blood pressure >105 mmHgXx_NEWLINE_xXPoorly controlled hypertension (defined as systolic blood pressure of>=150 millimeter of mercury (mmHg) or diastolic blood pressure of >100 mmHg based on a mean of three measurements at approximately 2-minute intervals)Xx_NEWLINE_xXUncontrolled hypertension (systolic pressure > 140 mmHg or diastolic pressure > 90 mmHg on repeated measurement) despite optimal medical managementXx_NEWLINE_xXGrade 3 hypertension (systolic blood pressure [SBP] >= 160 mmHg and/or diastolic blood pressure [DBP] >= 100 mmHg despite maximal medical therapy)Xx_NEWLINE_xXInadequately controlled hypertension (systolic blood pressure > 150 mmHg and/or diastolic blood pressure > 90 mmHg despite antihypertensive medication)Xx_NEWLINE_xXGenerally well-controlled blood pressure with systolic blood pressure =< 140 mmHg AND diastolic blood pressure =< 90 mmHg prior to enrollment; the use of antihypertensive medications to control hypertension is permittedXx_NEWLINE_xXInadequately controlled hypertension (systolic blood pressure of > 150 mmHg or diastolic pressure > 100 mmHg on anti-hypertensive medications)Xx_NEWLINE_xXUncontrolled hypertension: systolic blood pressure > 140 mmHg or diastolic blood pressure >90 mmHg on 2 or more antihypertensive medications, documented on 2 consecutive measurements taken at least 24 hours apart.Xx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure >= 140 and/or diastolic blood pressure >= 90 mmHg on antihypertensive medications), any prior history of hypertensive crisis or hypertensive encephalopathy, and history of myocardial infarction or unstable angina within 6 months prior to study enrollmentXx_NEWLINE_xXPoorly controlled hypertension [defined as systolic blood pressure of > or = 140 mmHg or diastolic blood pressure of > or = 90 mmHg].Xx_NEWLINE_xXBlood pressure must be well-controlled (less than or equal to 140/90 mmHg at screening) with or without antihypertensive medication. Patients must have no history of hypertensive crisis or hypertensive encephalopathy;Xx_NEWLINE_xXUncontrolled hypertension (systolic blood pressure >150 millimeters of mercury [mmHg] or diastolic pressure >90 mmHg despite optimal medical management).Xx_NEWLINE_xXSystolic blood pressure <90 mmHg.Xx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg, despite optimal medical managementXx_NEWLINE_xXPoorly controlled hypertension (defined as systolic blood pressure [SBP] of >= 150 mmHg or diastolic blood pressure [DBP] of >= 90 mmHg); Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; blood pressure must be re-assessed on two occasions that are separated by a minimum of 24 hours; the mean SBP/DBP values from each blood pressure assessment must be =< 150 systolic and 90 diastolic mmHg in order for a subject to be eligible for the studyXx_NEWLINE_xXUncontrolled hypertension, defined as systolic blood pressure >= 150 mmHg or a diastolic pressure >= 100 mmHg (the use of antihypertensive medications to achieve these goals is allowed)Xx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg, despite optimal medical managementXx_NEWLINE_xXUncontrolled hypertension, defined below:\r\n* Patients < 18 years old:\r\n** Diastolic Blood Pressure Within The Upper Limit Of Normal Defined as: A diastolic blood pressure (DBP) > the 95th percentile for age and gender despite optimal medical management\r\n* Patients >= 18 years old\r\n** Uncontrolled hypertension defined as systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg despite optimal medial managementXx_NEWLINE_xXPoorly controlled systemic vascular hypertension (systolic blood pressure > 140 mmHg, diastolic blood pressure > 90 mmHg)Xx_NEWLINE_xXUncontrolled hypertension with systolic blood pressure >160 mmHgXx_NEWLINE_xXPoorly controlled hypertension (defined as requiring changes in any hypertensive regimen within 1 week of study entry) or patients diagnosed with hypertension based on repeat blood pressure measurements of > 160/90 mmHg at screeningXx_NEWLINE_xXSubject has severe or uncontrolled systemic diseases including uncontrolled hypertension (blood pressure > 150/100 mmHg) or active bleeding diatheses.Xx_NEWLINE_xXPatients who have uncontrolled hypertension (defined as sustained systolic blood pressure >= 160 mmHg or diastolic >= 100 mmHg)Xx_NEWLINE_xXUncontrolled hypertension (defined as systolic blood pressure [SBP] of >= 140 mmHg or diastolic blood pressure [DBP] of >= 90 mmHg)Xx_NEWLINE_xXPoorly controlled hypertension (systolic blood pressure [SBP] >= 140 mmHg or diastolic blood pressure [DBP] >= 90 mmHg); the initiation or adjustment of antihypertensive medication(s) is permitted prior to study entryXx_NEWLINE_xXUncontrolled hypertension (systolic pressure > 140 mmHg or diastolic pressure > 90 mmHg on repeated measurement) despite optimal medical managementXx_NEWLINE_xXNo uncontrolled hypertension (systolic blood pressure =< 160 millimeters of mercury [mmHg] or diastolic =< 100 mmHg); patients with hypertension must be adequately controlled with appropriate anti-hypertensive therapy or dietXx_NEWLINE_xXInadequately controlled hypertension (defined as systolic blood pressure > 150 mmHg and/or diastolic blood pressure > 100 mmHg); anti-hypertensive therapy to achieve these parameters is allowedXx_NEWLINE_xXSevere untreated resting arterial hypertension (> 200 mmHg systolic, > 120 mmHg diastolic) at the time of enrollmentXx_NEWLINE_xXSystolic pressure > 180 mmHg or diastolic pressure > 100 mmHg at the time of study enrollmentXx_NEWLINE_xXSitting systolic blood pressure > 90 mmHgXx_NEWLINE_xXSystolic blood pressure ?180 mmHg or diastolic blood pressure ?110 mmHg;Xx_NEWLINE_xXSystolic pressure > 180 mmHg or diastolic pressure > 100 mmHg at the time of study enrollmentXx_NEWLINE_xXSystolic pressure > 180 mmHg or diastolic pressure > 100 mmHg at the time of study enrollmentXx_NEWLINE_xXUncontrolled hypertension (systolic blood pressure >= 140 mmHg or diastolic blood pressure >= 90 mmHg)Xx_NEWLINE_xXLow resting systolic blood pressure: < 90 mmHgXx_NEWLINE_xXUncontrolled arterial hypertension (systolic blood pressure > 200 mmHg, diastolic > 110 mmHg)Xx_NEWLINE_xXUncontrolled or poorly controlled hypertension, defined as systolic blood pressure >= 140 mmHg or diastolic blood pressure >= 90 mmHg, whether or not the subject is receiving anti-hypertensive treatment; subjects may be rescreened if the blood pressure is successfully and promptly controlled within 5 days using conventional anti-hypertensive therapy to achieve optimal blood pressure control (< 140/90 mmHg)Xx_NEWLINE_xXUncontrolled severe hypertension (systolic > 200mmHg or diastolic > 120 mmHg)Xx_NEWLINE_xXSubjects who have diabetes or uncontrolled hypertension are not eligible; NOTE: for the purposes of this study, uncontrolled will be defined as diastolic pressure over 100 mmHgXx_NEWLINE_xXPatients who are hypotensive with a systolic blood pressure reading of < 110 mmHg at any time over the 3 days prior to study entryXx_NEWLINE_xXPoorly controlled hypertension (systolic blood pressure > 180 mmHg or diastolic blood pressure > 1000 mmHg), with or without antihypertensivesXx_NEWLINE_xXHave uncontrolled hypertension and resting blood pressure exceeding 140/80 mmHgXx_NEWLINE_xXUncontrolled hypertension (mmHg > 160 systolic or > 90 diastolic)Xx_NEWLINE_xXBlood pressure between 90 and 150 mmHg systolic, inclusive, and not higher than 90 mmHg diastolic.Xx_NEWLINE_xXUncontrolled hypertension defined by a Systolic Blood Pressure (SBP) ? 160 mmHg and/or Diastolic Blood Pressure (DBP) ? 100 mmHg, with or without anti-hypertensive medication.Xx_NEWLINE_xXIntraocular pressure > 21 mmHg as measured by tonometryXx_NEWLINE_xXUncontrolled hypertension defined as systolic blood pressure ? 160 mmHg or diastolic blood pressure ? 100 mmHg, despite medical managementXx_NEWLINE_xX