Patients must not have received immunization with an attenuated live vaccine (e.g., intranasal influenza, measles, mumps, and rubella [MMR], oral polio, varicella, zoster, yellow fever, and Bacillus Calmette–Guerin [BCG] vaccines) within seven days prior to registration nor have plans to receive such vaccination while on protocol treatmentXx_NEWLINE_xXPatients must not have received live vaccines within 30 days prior to registration; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, shingles, yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatients must not have received live vaccines within 42 days prior to registration; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, shingles, yellow fever, rabies, Bacillus Calmette–Guerin (BCG), and typhoid (oral) vaccine; seasonal influenza vaccines for injection are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are not allowedXx_NEWLINE_xXHas received a live-virus vaccination within 30 days of planned treatment start. Seasonal flu vaccines that do not contain live virus are permitted.Xx_NEWLINE_xXSubjects should not be vaccinated with live attenuated vaccines within one month prior to starting tremelimumab treatmentXx_NEWLINE_xXUse of any live vaccines within 4 weeks of initiation of study treatmentXx_NEWLINE_xXHas received a live vaccine within 30 days prior to planned start of study therapy; NOTE: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccination within 4 weeks of the first dose of avelumab and while on study is prohibited except for administration of inactivated vaccines (e.g. inactivated influenza vaccines).Xx_NEWLINE_xXHas received a live vaccine within 30 days of the planned start of study therapy. Seasonal flu vaccines that do not contain live virus are permitted.Xx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXLive-virus vaccination -4 weeks NOTE: Seasonal flu vaccines that do not contain live virus are not an exclusion.Xx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy;\r\nNOTE: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXThe subject has received a live vaccine within 28 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for infection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (i.e. Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine =< 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXUse of any live vaccines against infectious diseases (e.g. influenza, varicella, pneumococcus) within 4 weeks of initiation of study treatment.Xx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatient has received a live vaccine within 30 days of study day 1; note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXCOHORT 1: Has received a live vaccine within 30 days of planned start of study therapy\r\n* NOTE: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXCOHORT 2: Has received a live vaccine within 30 days of planned start of study therapy\r\n* NOTE: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live-virus vaccine within 30 days of planned start of study drug. Seasonal flu vaccines that do not contain live virus are permitted.Xx_NEWLINE_xXHas been administered a live vaccine within 4 weeks (28 days) of initiation of study therapy. Patients are eligible if 28 days have elapsed since receipt of vaccine and initiation of study treatment. (NOTE: seasonal vaccines for influenza are generally inactivated vaccines and are allowed. Intranasal vaccines are live vaccines; and are not allowed).Xx_NEWLINE_xXUse of any live vaccines (eg, intranasal influenza, measles, mumps, rubella, oral polio, BCG, yellow fever, varicella, and TY21a typhoid vaccines) within 28 daysXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette–Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXUse of live vaccines within four weeks of starting abataceptXx_NEWLINE_xXLive vaccines within 30 days prior to the first dose of trial therapy and during trial treatment.Xx_NEWLINE_xXHas received a live-virus vaccination within 28 days of planned treatment start. Seasonal flu vaccines that do not contain live virus are permitted.Xx_NEWLINE_xXReceived a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; (Note: seasonal influenza vaccines for injection are allowed as they are inactivated; however, intranasal influenza vaccines are live attenuated vaccines and are NOT allowed)Xx_NEWLINE_xXLive-virus vaccination within 30 days of the first dose of mRNA-4157 or pembrolizumab. Seasonal flu vaccines that do not contain live virus are permittedXx_NEWLINE_xXPatients who have received a live vaccine within 30 days of the start date of the planned study therapy; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed.Xx_NEWLINE_xXVaccination with live attenuated vaccines within 4 weeks of first study agent administrationXx_NEWLINE_xXPatients who received a live vaccine within 30 days of planned start of study therapy are not eligible; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster, yellow fever, rabies, bacillus Calmette-Guerin (BCG), and typhoid vaccine\r\n* NOTE: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXReceipt of a live vaccine within 30 days prior to starting study drug; examples of live vaccines are: intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guerin (BCG), yellow fever, varicella, and TY21a typhoid vaccinesXx_NEWLINE_xXLive vaccines within 30 days prior to the first dose of trial treatment; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXReceived a live vaccine within 30 days prior to the first dose of trial treatment. Examples of live vaccines include, but are not limited to: measles, mumps, rubella, chicken pox, yellow fever, rabies, BCG, and typhoid (oral) vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g. Flu-Mist®) are live attenuated vaccines and are not allowed.Xx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines within one week of study entry or during study period; close contact with those who have received attenuated live vaccines should be avoided during treatment with everolimus; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXThe participant has received a live vaccine within 28 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for infection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (i.e. Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXPatient has received a live vaccine within 30 days of study day 1\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days prior to the first dose of trial treatment; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy (note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and shingles are not allowed)Xx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed? however intranasal influenza vaccines (e.g., FluMist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; NOTE: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXUse of any live vaccines against infectious diseases within 4 weeks of initiation of study treatment.Xx_NEWLINE_xXReceived a live vaccine within 30 days prior to the first study treatment; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g. FluMist) are live attenuated vaccines and are not allowedXx_NEWLINE_xXPatients who have received the last vaccination of a live vaccine =< 30 days prior to enrollment are ineligible; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella, yellow fever, rabies, bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g. Flu-Mist) are live attenuated vaccines, and must meet timeline for live vaccineXx_NEWLINE_xXEXCLUSION CRITERIA FOR STRATUM C: Patients who have received the last vaccination of a live vaccine =< 30 days prior to enrollment are ineligible; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella, yellow fever, rabies, BCG, and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g. Flu-Mist) are live attenuated vaccines, and must meet timeline for live vaccineXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette–Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXReceived a live vaccine within 30 days prior to the first dose of MK-3475; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g. FluMist) are live attenuated vaccines and are not allowedXx_NEWLINE_xXReceived a live vaccine within 30 days prior to the first dose of MK-3475; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g. FluMist) are live attenuated viruses and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy.\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed.Xx_NEWLINE_xXAdministration of live vaccines within 21 days prior to enrollmentXx_NEWLINE_xXPatients must not have received live vaccines within 30 days prior to trial registration. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, shingles, yellow fever, rabies, bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed.Xx_NEWLINE_xXVaccine administration within 4 weeks of M7824 administration. Vaccination with live vaccines while on trial is prohibited. Administration of inactivated vaccines is allowed (for example, inactivated influenza vaccines).Xx_NEWLINE_xXHas received a live vaccine within 30 days prior to the first dose of study drug. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette–Guerin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (eg, FluMist) are live attenuated vaccines and are not allowedXx_NEWLINE_xXReceived live attenuated vaccines within 30 days of first dose.Xx_NEWLINE_xXAny vaccinations four weeks prior to the first vaccination cycle or live vaccines at any time during the studyXx_NEWLINE_xXReceipt of live-virus vaccines within 28 days prior to the initiation of study treatment or need for live-virus vaccines at any time during study treatmentXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXClinically significant cardiac disease, including unstable angina, acute myocardial infarction within 6 months from day 1 of study drug administration, New York Heart Association class III or IV congestive heart failure, and arrhythmia requiring therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed within 30 days prior to initiation of treatmentXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of avelumabXx_NEWLINE_xXVaccine administration within 4 weeks of M7824 administration. Vaccination with live vaccines while on trial is prohibited. Administration of inactivated vaccines is allowed (for example, inactivated influenza vaccines).Xx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatients who have received a live vaccine within 30 days of the start date of the planned study therapy; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine; note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of enrollmentXx_NEWLINE_xXReceipt of live-virus vaccines within 28 days prior to the initiation of study treatment or need for live-virus vaccines at any time during study treatmentXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* NOTE: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatients must not have received live vaccines within 42 days prior to registration; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, shingles, yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXCurrent or recent treatment with therapeutic antibiotics, live attenuated vaccines or systemic immunostimulatory/immunosuppresive medicationXx_NEWLINE_xXLive vaccines within 30 days prior to the first dose of trial treatment and while participating in the trial; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster, yellow fever, rabies, Bacille Calmette-Guerin (BCG), and typhoid vaccineXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccination within 4 weeks of the first dose of study drug and while on trials is prohibited except for administration of inactivated vaccines; note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatient has received a live vaccine within 4 weeks prior to the first dose of treatment \r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not permittedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of enrollmentXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of initiation of study therapy. Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed.Xx_NEWLINE_xXVaccination with live attenuated vaccines within 4 weeks of first study agent administrationXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu?Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy. Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines are live attenuated vaccines, and are not allowed.Xx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXNote: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy. Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed.Xx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXReceived a live vaccine =< 30 days prior to registration\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines within one week (7 days) of study entry or during study period; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed.Xx_NEWLINE_xXHas received a live vaccine within 30 days of on-study date\r\n*Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; NOTE: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy (cycle 1, day 1)\r\n* Note: The killed virus vaccines used for seasonal influenza vaccines for injection are allowed; however intranasal influenza vaccines (e.g., FluMist) are live attenuated vaccines and are not allowedXx_NEWLINE_xXReceived a live vaccine within 30 days of planned start of study therapy; NOTE: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live-virus vaccination within 30 days of planned treatment start. Seasonal flu vaccines that do not contain live virus are permittedXx_NEWLINE_xXHas received a live-virus vaccination within 30 days of planned start of study therapy. Seasonal flu vaccines that do not contain live virus are permitted.Xx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days prior to first dose of therapy; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines are live attenuated vaccines, and are not allowedXx_NEWLINE_xXReceipt of live-virus vaccines within 28 days prior to the initiation of study treatmentXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatients who have had influenza, hepatitis, or other vaccines within a month prior to initiation of study drugsXx_NEWLINE_xXVaccination (live attenuated virus) within 4 weeks of the first dose of avelumab and while on trials is prohibited except for administration of inactivated vaccines.Xx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy. Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drug.Xx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; NOTE: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live-virus vaccination within 30 days of planned treatment start. Note: Seasonal flu vaccines that do not contain live virus are permitted.Xx_NEWLINE_xXLive virus vaccination within 4 weeks of the first dose of avelumab (inactivated vaccines are allowed)Xx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy. Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however, intranasal influenza vaccines (eg, Flu-Mist®) are live attenuated vaccines, and are not allowed.Xx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatients are prohibited from receiving the following therapies during the screening and treatment phases of this trial:\r\n* Antineoplastic systemic chemotherapy or biological therapy\r\n* Immunotherapy not specified in this protocol\r\n* Chemotherapy not specified in this protocol\r\n* Investigational agents other than anetumab ravtansine and MK-3475 (pembrolizumab)\r\n* Radiation therapy \r\n** Note: Radiation therapy to a symptomatic solitary lesion or to the brain may be considered on an exceptional case by case basis after consultation with Cancer Therapy Evaluation Program (CTEP); the patient must have clear measurable disease outside the radiated field; administration of palliative radiation therapy will be considered clinical progression for the purposes of determining progression free survival (PFS)\r\n* Live vaccines within 30 days prior to the first dose of trial treatment and while participating in the trial; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, Bacillus Chalmette–Guerin (BCG), and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed\r\n* Systemic glucocorticoids for any purpose other than to modulate symptoms from an event of suspected immunologic etiology; the use of physiologic doses of corticosteroids may be approved after consultation with the study principal investigator (PI) and CTEPXx_NEWLINE_xXPatients should not be vaccinated with live attenuated vaccines within 1 month of starting pembrolizumab treatmentXx_NEWLINE_xXHas received a live vaccine within 28 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed within 28 days prior to initiation of treatmentXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy. Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days prior to planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatient has received a live vaccine within 30 days of study day 1\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXNon-oncology vaccine therapies for prevention of infection disease (e.g. seasonal flu vaccine, human papilloma virus vaccine) within 4 weeks of study drug administration; vaccination while on study is also prohibited except for administration of inactivated vaccines (e.g. inactivated influenza vaccines)Xx_NEWLINE_xXAny vaccination within 4 weeks of the first dose of avelumab, with the following exceptions:\r\n* Administration of inactivated vaccines, including inactivated flu vaccines, are allowable; however, they should not be given within 2 weeks prior to starting study treatmentXx_NEWLINE_xXReceived live vaccine within 28 days prior to enrollment; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n*Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXLive vaccine within 30 days of planned start of study drug regimen; seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines within one week of study entry or during study periodXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXLive vaccines within 28 days prior to study pre-registrationXx_NEWLINE_xXVaccination with live vaccines within 28 days prior to the start of Cycle 1Xx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines within one week (7 days) of study entry or during study periodXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of enrollmentXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of registration; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed? however intranasal influenza vaccines (e.g., FluMist) are live attenuated vaccines, and are not allowed within 30 daysXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXReceipt of live-virus vaccines within 28 days prior to the initiation of study treatment or need for live-virus vaccines at any time during study treatmentXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXAdministration of a live vaccine within 30 days prior to initiating study treatment; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are permitted; however, intranasal influenza vaccines (eg, Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy (cycle 1, day 1); Note: the killed virus vaccines used for seasonal influenza vaccines for injection are allowed; however intranasal influenza vaccines (e.g., FluMist) are live attenuated vaccines and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy (cycle 1, day 1); Note: the killed virus vaccines used for seasonal influenza vaccines for injection are allowed; however intranasal influenza vaccines (e.g., FluMist) are live attenuated vaccines and are not allowedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of enrollmentXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy (cycle 1, day 1); Note: the killed virus vaccines used for seasonal influenza vaccines for injection are allowed; however intranasal influenza vaccines (e.g., FluMist) are live attenuated vaccines and are not allowedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of enrollmentXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed? however intranasal influenza vaccines (e.g., Flu­Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., FluMist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are not allowedXx_NEWLINE_xXLive vaccines are not permitted within 28 days of study registrationXx_NEWLINE_xXLive vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist®) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatients should not be vaccinated with live attenuated vaccines within 30 days of starting durvalumab or tremelimumab treatmentXx_NEWLINE_xXHas received any non-oncology vaccine therapy used for prevention of infectious diseases (for up to 30 days before or after any dose of pembrolizumab); Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines and are not allowedXx_NEWLINE_xXHave received any live vaccine therapies used for the prevention of infectious disease within 28 days prior to enrollment and during treatment period; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, Bacille Calmette-Guerin (BCG), and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (eg, Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist®) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of randomizationXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\nNote: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: seasonal influenza vaccines for injection are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (eg, flu-mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days prior to the first dose of trial treatment; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist®) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatients who have received any non-oncology live vaccine therapy used for prevention of infectious diseases within 28 days of study treatment; examples include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine\r\n* Note: seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g. Flu-Mist) are live-attenuated vaccines, and are not allowed within 28 days of study treatmentXx_NEWLINE_xXReceived a live vaccine within 30 days prior to the first dose of pembrolizumab; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g. FluMist) are live attenuated vaccines and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy;\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of study entryXx_NEWLINE_xXReceived a live vaccine within 30 days prior to the first dose of MK-3475; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g. FluMist) are live attenuated vaccines and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXJUST PRIOR TO FIRST VACCINATION (WITHIN 21 DAYS): in addition to above exclusion criteria unless specified differently below: has received a live vaccine within 30 days of planned start of study therapy; NOTE: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXUse of live vaccines against infectious disease (e.g. varicella) within 28 days of initiation of study therapy; killed vaccinations (e.g. influenza) are allowed at any appropriate time before and during the studyXx_NEWLINE_xXVaccination with live inactivated viral strains for the prevention of infectious diseases within 4 weeks of the start of the study treatment, inactivated influenza vaccines are permitted while on trialXx_NEWLINE_xXReceived a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXUse of live vaccines against infectious diseases (e.g. influenza, varicella) within 28 days of initiation of study therapy:\r\n* NOTE: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette–Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXHave received live vaccines within past 30 days (inactivated vaccines are allowed; seasonal vaccines should be up to date prior to first infusion day)Xx_NEWLINE_xXVaccination within 4 weeks of the first dose of avelumab and while on trial is prohibited except for administration of inactivated vaccines (for example, inactivated influenza vaccines)Xx_NEWLINE_xXSubjects should not be vaccinated with live attenuated vaccines within one month prior to starting tremelimumab treatmentXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines within one week of study entry or during study period; close contact with those who have received attenuated live vaccines should be avoided during treatment with pegylated interferon; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, bacillus Calmette-Guérin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXPatients who have had flu, hepatitis, or other vaccines within a month prior to initiation of study drugsXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of initiation of therapyXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXVaccination with live vaccines within 28 days prior to start of treatmentXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXUse of any live vaccines against infectious diseases within 4 weeks of initiation of study treatment. Non-live vaccination (eg, influenza) are permitted anytime during treatmentXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXImmunization with attenuated live vaccines within one week of study entry or during study period; close contact with those who have received attenuated live vaccines should be avoided during treatment with everolimus; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines =< 7 days of study entry or during study periodXx_NEWLINE_xXNo immunizations with attenuated live vaccines within one week of study entry or during study periodXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live virus vaccine within 30 days of the planned first dose of study therapy NOTE: seasonal influenza vaccines for injection which are generally inactivated flu vaccines are permitted; however, intranasal influenza vaccines (e.g., Flu-Mist®) are live attenuated vaccines and are not permitted;Xx_NEWLINE_xXLive-virus vaccines =< 28 days prior to registrationXx_NEWLINE_xXClinically significant cardiac disease, including unstable angina, acute myocardial infarction within 6 months from day 1 of study drug administration, New York Heart Association class III or IV congestive heart failure, and arrhythmia requiring therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed within 30 days prior to initiation of treatmentXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccination within 4 weeks of the 1st dose of pembrolizumab and while on study is prohibited EXCEPT for administration of inactivated vaccines (e.g. inactivated influenza vaccine)Xx_NEWLINE_xXHas received a live-virus vaccination within 30 days of planned treatment start. Seasonal flu vaccines that do not contain live virus are permitted.Xx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines are live attenuated vaccines, and are not allowedXx_NEWLINE_xXUse of any live vaccines within 4 weeks of initiation of study treatment.Xx_NEWLINE_xXAdministration of live attenuated vaccines within 4 weeks of study enrollment.Xx_NEWLINE_xXPrevious treatment with live vaccine within 30 days of planned start of study drugs (seasonal flu vaccines that do not contain a live virus are permitted).Xx_NEWLINE_xXHas received a live vaccine within 30 days prior to the first dose of study drug. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g. FluMist) are live attenuated vaccines and are not allowedXx_NEWLINE_xXHas received a live-virus vaccination within 30 days prior to start of study drug treatment. a. Seasonal flu and other inactivated vaccines that do not contain live virus are permitted.Xx_NEWLINE_xXVaccination with live attenuated vaccines within 4 weeks of first study agent administrationXx_NEWLINE_xXHas received a live vaccine within 30 days prior to the first dose of trial treatment; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXREGISTRATION TO TREATMENT (STEP 1): Patient must not have received a live vaccine within 30 days of planned start of study therapy\r\n* NOTE: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXREGISTRATION TO TREATMENT (STEP 2): Patient must not have received a live vaccine within 30 days of planned start of study therapy; NOTE: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days prior to registration for protocol therapy\r\n* NOTE: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXReceived a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy \r\n*Note: Seasonal influenza vaccines for injection are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are not allowedXx_NEWLINE_xXReceipt of live vaccination within 28 days before randomization; seasonal flu vaccines that do not contain live virus are permittedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatients who have received a live vaccine within 30 days of planned start of study therapy; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXAttenuated vaccines within 30 days prior to the first dose of trial treatment and while participating in the trial; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, seasonal flu, hemagglutinin type 1 (H1) neuraminidase type 1 (N1) flu, rabies, bacillus Calmette-Guerin (BCG), and typhoid vaccineXx_NEWLINE_xXTREATMENT: Patients who have received live attenuated vaccines within 1 week of the start are ineligible to receive everolimusXx_NEWLINE_xXPatients who have received a live, attenuated vaccines within 4 weeks of first dose of drugXx_NEWLINE_xXReceived a live vaccine =< 30 days prior to registration; NOTE: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., FluMist®) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXParticipants who have received a live vaccine within 30 days of planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster, yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXLive vaccines within 30 days prior to the first dose of IL-2 and while participating in the trial; examples of live vaccines include, but are not limited to, measles, mumps, rubella, chicken pox, yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu - Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXHas received a live vaccine within 30 days prior to the first dose of study drug; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette–Guerin (BCG), and typhoid vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (eg, FluMist) are live attenuated vaccines and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatient has been vaccinated with live attenuated vaccines within 4 weeks before study vaccinationXx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines during study period or within 1 week of study entryXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXTaking any of the following agents:\r\n* Chronic treatment with systemic steroids or another immunosuppressive agent (use of steroids as part of management of everolimus toxicities will be allowed)\r\n* Live vaccines\r\n* Patients who have received live attenuated vaccines within 1 week of start of everolimus and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, bacillus Calmette–Guérin (BCG), yellow fever, varicella and TY21a typhoid vaccines\r\n* Drugs or substances known to be inhibitors or inducers of the isoenzyme cytochrome P450 family 3, subfamily A, polypeptide 4 (CYP3A)Xx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines within one week of starting study drug or during study period; close contact with those who have received attenuated live vaccines should be avoided during treatment with everolimus; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette–Guérin (BCG), yellow fever, varicella and typhoid vaccine live oral (TY)21a typhoid vaccinesXx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines during study period or within 1 week of study entry; close contact with those who have received attenuated live vaccines should be avoided during treatment with everolimus; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines within one week of study entry or during study periodXx_NEWLINE_xXHas received a live-virus vaccination within 30 days of planned treatment start. Note: Seasonal flu vaccines that do not contain live virus are permitted.Xx_NEWLINE_xXVaccination with live or live/attenuated viruses within 55 days of the first dose of avelumab and while on trial is prohibited except for administration of inactivated vaccinesXx_NEWLINE_xXPatients must not have received live vaccines within 42 days prior to registration; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, shingles, yellow fever, rabies, bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of study drug and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXReceipt of live vaccines within 30 days before the first dose of trial treatment and while participating in the trial; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, seasonal flu, H1N1 flu, rabies, bacillus Calmette-Guérin (BCG), and typhoid vaccineXx_NEWLINE_xXHas received a live vaccine within 30 days of the planned start of study therapy. Seasonal flu vaccines that do not contain live virus are permitted.Xx_NEWLINE_xXVaccination with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXHave received a live vaccine within 30 days prior to enrollment. Seasonal flu vaccines that do not contain live virus are permitted.Xx_NEWLINE_xXreceived live vaccines.Xx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of study entryXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXPatients who plan to receive live attenuated vaccines within 1 week of start of everolimus and during the study. Patient should also avoid close contact with others who have received live attenuated vaccines. Examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, BCG, yellow fever, varicella and TY21a typhoid vaccines.Xx_NEWLINE_xXVaccination with live vaccines within 28 days prior to randomizationXx_NEWLINE_xXAdministration of live attenuated vaccines within eight weeks of start of study treatment (day -1) and throughout the studyXx_NEWLINE_xXReceived a live vaccine within 30 days of planned start of study therapy;\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXWithin 30 days prior to the planned start of study treatment:\r\n* Has received a live vaccine; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster, yellow fever, rabies, Bacillus Calmette–Guerin (BCG), and typhoid vaccine; seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed\r\n* Has participated in a study of an investigational agent and received study therapy or used an investigational deviceXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXReceipt of live-virus vaccines within 28 days prior to the initiation of study treatment or need for live-virus vaccines at any time during study treatmentXx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines within one week of study entry or during study period. Close contact with those who have received attenuated live vaccines should be avoided during treatment with everolimus. Examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, bacillus calmette-guerin (BCG), yellow fever, varicella and TY21a typhoid vaccines.Xx_NEWLINE_xXPatients should not be vaccinated with live attenuated vaccines within 1 month of starting tremelimumab and/or durvalumab (MEDI4736) treatmentXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of the first dose of study drugXx_NEWLINE_xXHas received a live vaccine within 30 days prior to the first dose of trial treatment\r\n* Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccinated with live attenuated vaccines =< 4 weeks from starting study drugsXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXSubjects should not be vaccinated with live attenuated vaccines within one month prior to starting tremelimumab treatmentXx_NEWLINE_xXParticipant has received a live-virus vaccination within 30 days of planned treatment start. Seasonal flu vaccines that do not contain live virus are permitted.Xx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of study entryXx_NEWLINE_xXPatients taking live vaccines including yellow fever vaccinationsXx_NEWLINE_xXVaccination within 4 weeks of the first dose of avelumab and while on trial is prohibited except for administration of inactivated vaccines (for example, inactivated influenza vaccines).Xx_NEWLINE_xXReceived live attenuated vaccine within 1 week of start of everolimus (i.e. intranasal influenza, measles, mumps, rubella, oral polio, Bacille de Calmette et Guerin [BCG], yellow fever, varicella, and typhoid vaccine live oral [TY21a] typhoid vaccines)Xx_NEWLINE_xXReceived a live vaccine within 30 days prior to the first dose of trial treatment: Examples of live vaccines include, but are not limited to: measles, mumps, rubella, chicken pox, yellow fever, rabies, BCG, and typhoid (oral) vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g. Flu-Mist®) are live attenuated vaccines and are not allowed.Xx_NEWLINE_xXPatients who have received live attenuated vaccines =< 1 week prior to registration and during the study; note: patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXPatient has had live vaccines within 30 days before the first dose of trial treatment and while participating in the trial; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, seasonal flu, H1N1 flu, rabies, bacille de Calmette et Guérin (BCG), and typhoid vaccineXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, BCG (bacillus Calmette-Guerin), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus, or have plans to receive such vaccination while on protocol treatment; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette–Guérin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXSubjects that have been vaccinated with live, attenuated vaccines within 4 weeks of the first dose of study drug are not eligibleXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus and during the studyXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study medication. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guérin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g. FluMist®) are live attenuated vaccines and are not allowed.Xx_NEWLINE_xXPatient must not be vaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXUse of live or live attenuated vaccines within 30 days prior to randomizationXx_NEWLINE_xXPatients who have received a live vaccine within 4 weeks prior to or after any dose of MK-3475\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXReceipt of live-virus vaccines within 28 days prior to the initiation of study treatment or need for live-virus vaccines at any time during study treatmentXx_NEWLINE_xXVaccinated with live attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXPatients should not be vaccinated with live attenuated vaccines within 1 month of starting tremelimumab treatmentXx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines within one week of study entry or during study period; close contact with those who have received attenuated live vaccines should be avoided during treatment with everolimus; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette–Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXPatients should not receive immunization with attenuated liver vaccines within one week of study entry or during study period; close contact with those who have received attenuated liver vaccines should be avoided during treatment with everolimus; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXParticipants who have received immunizations with attenuated live vaccines within one week of study entry are not eligible; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXPatients who have received attenuated live vaccines within one week of study entry; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guerin [BCG], yellow fever, varicella, and TY21a typhoid vaccinesXx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines within 1 week of study entry or during study period; close contact with those who have received attenuated live vaccines should be avoided during treatment with everolimus; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacille Calmette Guerin (BCG), yellow fever, varicella, and TY21a typhoid vaccinesXx_NEWLINE_xXPatients who received live vaccines or who have close contact with people who have received live vaccines within 7 days of day 1 of study treatmentXx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines during study period or within 1 week of study entry; close contact with those who have received attenuated live vaccines should be avoided during treatment with everolimus; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, bacillus Calmette-Guérin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines within one week of study entry or during study period; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacille Calmette-Guerin (BCG), yellow fever, varicella, and TY21a typhoid vaccinesXx_NEWLINE_xXEXPANSION COHORT ONLY: Patients should not receive immunization with attenuated live vaccines within one week of study entry or during study period; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacille Calmette-Guerin (BCG), yellow fever, varicella, and TY21a typhoid vaccinesXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccination within 4 weeks of first dose of AGEN2034 and while on study except for administration of inactivated vaccines (e.g., inactivated influenza vaccines).Xx_NEWLINE_xXReceived a live vaccine within 30 days of planned start of study therapy. Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist®) are live attenuated vaccines, and are not allowed.Xx_NEWLINE_xXHas received a live-virus vaccination within 30 days of planned treatment start. Seasonal flu vaccines that do not contain live virus are permittedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXReceipt of live vaccines against infectious diseases within 28 days;Xx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* NOTE: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXReceipt of live vaccines with 4 weeks (28 days) of studyXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of initiation of therapyXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of enrollmentXx_NEWLINE_xXPatients who received DEPDC1, MPHOSPH1, URLC10, CDCA1, or KOC1 peptide vaccines beforeXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drug.Xx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette–Guérin (BCG), yellow fever, varicella and typhoid (TY)21a typhoid vaccinesXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live-virus vaccination within 30 days of planned start of study therapy. Seasonal flu vaccines that do not contain live virus are permitted.Xx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines during study periodXx_NEWLINE_xXExposure to oral or IV antibiotics within 2 weeks or live attenuated vaccines within 4 weeks prior to randomizationXx_NEWLINE_xXVaccinated with live, attenuated vaccines with 4 weeks of first does of study drugXx_NEWLINE_xXVaccination with live vaccines within 28 days prior to treatmentXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guérin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXReceived immunization with attenuated live vaccines =< 7 days prior to study entry or during study period; NOTE: Close contact with those who have received attenuated live vaccines should be avoided during treatment with sirolimus; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette–Guérin (BCG), yellow fever, varicella and typhoid (TY)21a typhoid vaccinesXx_NEWLINE_xXReceive immunization with attenuated live vaccines within one week of randomization or during the study period.Xx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines within one week of study entry or during study period; close contact with those who have received attenuated live vaccines should be avoided during treatment with everolimus; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guérin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXVaccination with live, attenuated vaccines within 4 weeks of first dose of this studyXx_NEWLINE_xXPlanned immunization with attenuated live vaccines =< 7days prior to registration or during study period; note: close contact with those who have received attenuated live vaccines should be avoided during treatment with everolimus; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacille Calmette-Guérin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines during study period or within 1 week of study entry; close contact with those who have received attenuated live vaccines should be avoided during treatment with RAD001; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines within one week of study entry or during study periodXx_NEWLINE_xXPatients should not receive immunization with attenuated live vaccines within one week of study entry or during study period; close contact with those who have received attenuated live vaccines should be avoided during treatment with everolimus; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guérin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXVaccinated with live, attenuated vaccines =< 4 weeks prior to registrationXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of treatmentXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXPatients who have received vaccination with live attenuated vaccines within 6 months prior to registration are not eligibleXx_NEWLINE_xXHas received a live vaccine within 30 days before to the first dose of trial treatment; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, seasonal flu (some), H1N1 flu, rabies, Bacille Calmette-Guerin (BCG), and typhoid vaccine; seasonal flu vaccines that do not contain live virus are permittedXx_NEWLINE_xXPatients must not have received any live vaccine within 30 days prior to registration; seasonal flu vaccines that do not contain live virus are permittedXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of starting ibrutinibXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; NOTE: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed within 30 days prior to initiation of treatmentXx_NEWLINE_xXLive attenuated vaccinesXx_NEWLINE_xXLive attenuated vaccinesXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXVaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, bacillus Calmette-Guérin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXRECIPIENT: Live attenuated vaccinesXx_NEWLINE_xXEXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Vaccinated with live, attenuated vaccines within 4 weeks of first dose of study drugXx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, bacillus Calmette-Guérin (BCG), yellow fever, varicella and TY21a typhoid vaccinesXx_NEWLINE_xXLive attenuated vaccines within 90 days prior to leukapheresis.Xx_NEWLINE_xXPatients who have received live attenuated vaccines within 1 week of start of everolimus and during the study. Patient should also avoid close contact with others who have received live attenuated vaccines. Examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, BCG, yellow fever, varicella and TY21a typhoid vaccines;Xx_NEWLINE_xXVaccination with live attenuated vaccines within 4 weeks of study agent administrationXx_NEWLINE_xXHas received a live vaccine within 14 days of C11-AMT PET scan\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., FluMist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXReceived a live vaccine =< 30 days prior to registration; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed; routine vaccinations, including seasonal influenza, must be given >= 2 weeks prior to registrationXx_NEWLINE_xXPatients must not have received a live vaccine within 30 days of registration Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed)Xx_NEWLINE_xXVaccinated with live, attenuated vaccines within four weeks of the first dose of study drugXx_NEWLINE_xXUse of any live vaccines against infectious diseases within 4 weeks of initiation of study treatmentXx_NEWLINE_xXReceived a live vaccine =< 30 days of planned start of study therapy; NOTE: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXVaccination within 4 weeks of the first dose of avelumab and while on trials is prohibited except for administration of inactivated vaccines; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXRecent receipt of live attenuated vaccines.Xx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXReceived live vaccines within 30 days prior to enrollmentXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy; Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xXHas received a live vaccine within 30 days of planned start of study therapy\r\n* Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowedXx_NEWLINE_xX