Urine protein: creatinine (UPC) ratio < 1 or urine dipstick for proteinuria =< 2+ (note: if the UPC ratio is >= 1.0 then a 24-hour urine collection should be performed and this must demonstrate =< 1g of protein in 24 hours)Xx_NEWLINE_xXProteinuria at screening as demonstrated by urinalysis with proteinuria ? 2+ (patients discovered to have ?2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate ? 1g of protein in 24 hours to be eligible).Xx_NEWLINE_xXProteinuria with urinary protein is =< 1+ on dipstick or routine urinalysis, or a 24-hour urine collection for protein < 1000 mg of protein in 24 hours, within 28 days prior to administration of study treatmentXx_NEWLINE_xXBaseline urinalysis should show urine protein < 3+ and must be obtained within 28 days prior to registration; if urine protein is 3+ or greater, then urine protein by 24 hour collection must show less than 3 grams of proteinXx_NEWLINE_xXWithin 2 weeks prior to registration: Screening urine dipstick must equal 0 or “trace”; if urine dipstick results are >= 1+, or if dipstick was not performed, calculation of urine protein creatinine (UPC) is required and patients must have a UPC ratio =< 1 to participate in the studyXx_NEWLINE_xXUrine protein creatinine (UPC) =< 1; if UPC >= 1, then a 24-hour urine protein must be assessed; eligible patients must have a 24-hour urine protein value < 1 g/LXx_NEWLINE_xXWithin 14 days prior to registration: Urine protein creatinine (UPC) ratio must be < 1.0 gm; if UPC ratio >= 1, collection of 24-hour urine measurement of urine protein is recommended (24-hour urine protein level must be < 1000 mg for patient enrollment); UPC ratio of spot urine is an estimation of the 24-hour urine protein excretion – a UPC ratio of 1 is roughly equivalent to a 24-hour urine protein of 1 gmXx_NEWLINE_xXA urine sample tested for proteinuria by the dipstick method must indicate 0 -1+ protein; if dipstick reading is >= 2+, a 24-hour urine specimen must demonstrate < 1.0 g of protein per 24 hoursXx_NEWLINE_xXUrine protein: =< 30 mg/dl in urinalysis or =< 1+ on dipstick, unless quantitative protein is < 1000 mg in a 24 hour (h) urine sampleXx_NEWLINE_xXParticipants having greater than 1+ proteinuria on urinalysis will undergo 24-h urine collection for quantitative assessment of proteinuria. Participants with urine protein greater than or equal to 1 g/24-hour will be ineligible.Xx_NEWLINE_xXUrine protein to creatinine ratio < 1 OR 24-hour urine protein < 1 gXx_NEWLINE_xXUrine Protein to Creatinine Ratio (UPC) < 1Xx_NEWLINE_xXProteinuria as demonstrated by a urine protein:creatinine (UPC) ratio >= 1.0 at screening, or urine dipstick for proteinuria >= 2+ (patients discovered to have >= 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligible)Xx_NEWLINE_xXUrine M-Protein >= 200 mg/24 hours, ORXx_NEWLINE_xXProteinuria 3+ on dipstick analysis or > 500 mg/24 hoursXx_NEWLINE_xXUrinary protein is > 1 + on dipstick and the required following 24-hour urine collection shows urinary protein > 2000 mg;Xx_NEWLINE_xXUrine protein-creatinine ratio (UPCR) =< 1 on spot urinalysis or protein =< 500 mg/24 hour urineXx_NEWLINE_xXUrine M-protein ?200 mg/24 hours ; orXx_NEWLINE_xX? 200 mg/24 hours of monoclonal protein in the urine on 24-hour electrophoresisXx_NEWLINE_xXUrine protein to creatinine ratio of < 1, a urinalysis that is negative for protein, or a 24-hour urine protein level < 1000 mg/dLXx_NEWLINE_xXUrinary protein =< 1+ on dipstick or routine urinalysis (if urine dipstick or routine urinalysis is 2+, a 24-hour urine collection for protein must demonstrate < 1000 mg of protein in 24 hours)Xx_NEWLINE_xXSpot urine total protein:creatinine ratio >1,000 mg/gmXx_NEWLINE_xXUrine protein: creatinine ratio =< 1, within 14 days before the first dose of cabozantinibXx_NEWLINE_xXProteinuria =< 2+ by urinalysis or urine dipstickXx_NEWLINE_xXUrine protein/creatinine ratio of less than 1Xx_NEWLINE_xXUrine protein via dipstick =< 2+ or =< 100 mg/dlXx_NEWLINE_xXPatients with central pulmonary metastases or recent hemoptysis (>= 1/2 tea spoon [tsp] of red blood) within 28 days of registration\r\n* Patients with clinically significant proteinuria (i.e. > grade 1) or urine protein to creatinine ratio (UPC) ratio above 1.0\r\n* Patients with suspicion of transmural tumor bowel involvement based on the investigator's discretion may not enroll on this studyXx_NEWLINE_xXUrine protein to creatinine ratio (UPCR) =< 1 within 7 days before the first dose of cabozantinibXx_NEWLINE_xXUrine M-protein level >= 200 milligram per 24 hours (mg/24 hours); orXx_NEWLINE_xXParticipants with proteinuria >1+ on urinalysis will undergo 24-hour urine collection for quantitative assessment of proteinuria. Participants with urine protein ?1 g/24 hour will be ineligible.Xx_NEWLINE_xXUrinary protein =< 1+ on dipstick or routine urinary analysis (UA); if dipstick or routine UA is >= 2+, a 24-hour urine collection for protein must demonstrate < 1000 mg of protein in 24 hoursXx_NEWLINE_xXProteinuria as demonstrated by a urine protein to creatinine ratio (UPCR) of >=1.0 at screeningXx_NEWLINE_xXUrine protein: =< 30 mg/dl in urinalysis or =< 1+ on dipstick, unless quantitative protein is < 1000 mg in a 24 hour (h) urine sampleXx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXUrine M-protein ?200 mg/24 hours (any immunoglobulin heavy chain type measured by PEP).Xx_NEWLINE_xXMeasurable disease M protein component in serum (at least 0.5 g/dL) and/or urine (if present) (>=0.2 g excreted in a 24 hour collection sample).Xx_NEWLINE_xXPatients with proteinuria within 14 days of registration as demonstrated by either: urine protein creatinine (UPC) ratio >= 1.0 at screening OR urine dipstick for proteinuria 2+ (patients discovered to have 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24-hour urine collection, and must demonstrate =< 1 g of protein/24 hours to be eligible)Xx_NEWLINE_xXPersistent proteinuria >= grade 3 NCI-CTCAE v4.0 (> 3.5 g/24 hours [hrs], measured by urine protein:creatinine ratio on a random urine sample)Xx_NEWLINE_xXUrine protein <500 mg or urine protein: creatinine ratio (UPC) <1.0; andXx_NEWLINE_xXPersistent proteinuria >= grade 3 NCI-CTCAE v4.0 (> 3.5 g/24 hrs, measured by urine protein:creatinine ratio on a random urine sample)Xx_NEWLINE_xXUrine protein to creatinine ratio =< 1 (if urine protein creatinine ratio is > 1, then a 24-hour urine total protein must be assessed; subjects will be ineligible if the 24-hour urine protein is found to be > 1 gm)Xx_NEWLINE_xXProteinuria dipstick > 3+ or >= 2 gm/24 hoursXx_NEWLINE_xXUrine protein:creatinine ratio >= 1.0 at screeningXx_NEWLINE_xXDocumented baseline proteinuria > 1000 mg/day on 24 hour urine collection; only patients with 1+ or greater proteinuria on urinalysis (UA) and a spot urine protein: creatinine ratio of > 0.5 will undergo a 24 hour urine collection for quantitation of proteinuriaXx_NEWLINE_xXUrine protein / creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXUrine M-protein > 200 mg/24 hoursXx_NEWLINE_xX? 200 mg/24 hours of monoclonal protein in the urine on 24-hour urine electrophoresis (UPEP)Xx_NEWLINE_xXSubjects having > 1+ proteinuria on urine dipstick testing will undergo 24 hours (h) urine collection for quantitative assessment of proteinuria; subjects with urine protein >= 1 g/24h will be ineligibleXx_NEWLINE_xXHas greater than 1+ proteinuria on a urine dipstick or equivalent routine laboratory analysis will require further testing with a urine protein to creatinine ratio (UPCR); UPCR must be calculated as follows: UPCR = protein concentration (mg/dL)/creatinine (mg/dL); if the UPCR >= 1, then the patient will not be eligible for study entry; however, if urinalysis or equivalent routine laboratory analysis shows no protein, then UPCR testing is not requiredXx_NEWLINE_xXAdditional inclusion criteria for patients on the arm pembrolizumab plus ramucirumab:\r\n* Urinary protein is < 100 mg/dL on routine urinalysis. If urine routine urinalysis indicates proteinuria >= 100 mg/dL, then a 24-hour urine collection must be performed and must demonstrate urine protein < 2 g to allow the patient to participate in the study.Xx_NEWLINE_xXWithin 28 days prior to administration of study treatment: Urine protein: creatinine ratio (UPC) of =< 1Xx_NEWLINE_xXUrine protein to creatinine (UPC) ratio =< 1Xx_NEWLINE_xXObtained within 28 days prior to the first dose of cabozantinib: urine protein/creatinine ratio (UPCR) =< 1.Xx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXSerum M-protein level >=1.0 gram per deciliter (g/dL) or urine M-protein level >=200 mg/24 hours; orXx_NEWLINE_xXWithin 7 days before the first dose of study treatment: Urine protein to creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXObtained within 14 days prior to the first study treatment (cycle 1, day 1): urine dipstick for proteinuria < 2+ unless a 24-hour urine protein =< 1g of protein is demonstratedXx_NEWLINE_xX(Bevacizumab-related exclusion) Proteinuria as demonstrated by a urine protein:creatinine (UPC) ratio >= 1.0 at screeningXx_NEWLINE_xXUrine M-protein ?200 mg/24 hours and must have documented MM isotype by immunofixation (central laboratory).Xx_NEWLINE_xXUrine protein =< 1+ or =< 30 mg/dL OR urine protein/creatinine ratio =< 1, performed within 10 days of treatment initiationXx_NEWLINE_xXWithin 14 days prior to cycle 1 day 1 of treatment: Urinary albumin excretion < 1.0 g/24 hours (as estimated by urine protein-creatinine ratio)Xx_NEWLINE_xXFOR ALL PHASES (Ib AND II): Proteinuria of >= Common Terminology Criteria for Adverse Events (CTCAE) grade 3 as estimated by urine protein : creatinine ratio > 3.5 on a random urine sampleXx_NEWLINE_xXUrine M-protein ? 200 mg/24 hours ORXx_NEWLINE_xXUrine protein creatinine (UPC) ratio of < 1Xx_NEWLINE_xXPersistent proteinuria >= grade 3 per NCI-CTCAE v4.0 (> 3.5 g/24 hours [hrs], measured by urine protein: creatinine ratio on a random urine sample)Xx_NEWLINE_xXPersistent proteinuria >= grade 3 NCI-CTCAE version (v) 4.0 (> 3.5 g/24 hours [hrs], measured by urine protein: creatinine ratio on a random urine sample)Xx_NEWLINE_xXWithin 14 days prior to the first study treatment (cycle 1, day 1): Urine dipstick for proteinuria < 2+ or 24-hour urine protein < 1 g of protein is demonstratedXx_NEWLINE_xXProteinuria as demonstrated by a urine protein:creatinine (UPC) ratio >= 1.0 at screeningXx_NEWLINE_xXUrine protein =< 30 mg/gXx_NEWLINE_xXUrine protein/ creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXUrine Protein to Creatinine Ratio (uPCR) < 2.0Xx_NEWLINE_xXIf uPCR ? 2.0 then a 24-hour urine collection can be performed to qualify. If this is performed to qualify, the protein result must be < 2 g per 24 hours.Xx_NEWLINE_xXA urine protein:creatinine ratio of < 1 or < 1 g protein on 24-hour urine collectionXx_NEWLINE_xXUrine protein/creatinine ratio =< 1 OR 24-hour urine protein < 1.5 gram obtained =< 14 days prior to registrationXx_NEWLINE_xXUrine protein/creatinine ratio =< 1Xx_NEWLINE_xXUrine/protein creatinine ratio spot-check < 0.5 mg/mgXx_NEWLINE_xX> 30 mg/dL on urine analysis; patients with > 30 mg/dL on urine analysis on urine analysis will undergo 24-hour urine collection for quantitative assessment of proteinuria; subjects with 24-hour protein >= 1 g/24 hours will be ineligibleXx_NEWLINE_xXUrine protein =< 30 mg/dL in urinalysis or =< 1+ on dipstick, unless quantitative protein is < 1000 mg in a 24 hour urine sampleXx_NEWLINE_xXUrine protein creatine ratio (UPCR) < 1 prior to enrollmentXx_NEWLINE_xXUrine protein by dipstick <1+ or UPC =< 1.0 by urinalysisXx_NEWLINE_xXUrinary protein < 2+ by urine dipstick (if dipstick is >= 2+ then a 24-hour urine collection can be done and the patient may enter only if urinary protein is < 2 g per 24 hours)Xx_NEWLINE_xXThe patient’s urinary protein is =< 1+ on dipstick or routine urinalysis (urine analysis [UA]; if urine dipstick or routine analysis is >= 2+, a 24-hour urine collection for protein must demonstrate < 1000 mg of protein in 24 hours to allow participation in this protocol)Xx_NEWLINE_xXProteinuria > 2.0 g of protein in a 24-hour urine collection; all patients with 2 protein on dipstick urinalysis at baseline must undergo a 24-hour urine collection for proteinXx_NEWLINE_xXUrine protein screened by urine analysis for urine protein creatinine (UPC) ratio; for UPC ratio > 0.5, 24-hour urine protein must be obtained and must be < 1000 mgXx_NEWLINE_xXProteinuria of CTCAE grade 3 or higher (> 3.5 g/24 h, measured by urine protein: creatinine ratio on a random urine sample)Xx_NEWLINE_xXREGORAFENIB EXCLUSION CRITERIA: Persistent proteinuria >= grade 3 (> 3.5 g/24 hours [hrs], measured by urine protein:creatinine ratio on a random urine sample)Xx_NEWLINE_xXUrine protein > 2+; Patients discovered to have ? 1+ proteinuria on dipstick urinalysis at baseline should undergo a 24-hour urine collection and must demonstrate < 1 g of protein in 24-hour urine;Xx_NEWLINE_xXUrine dipstick for proteinuria < 2+ unless a 24-hour urine protein < 1 g of protein is demonstratedXx_NEWLINE_xXProteinuria at baseline; subjects unexpectedly found to have >= 2+ proteinuria on a urine dipstick at baseline should undergo a 24-hour urine which must be an adequate collection and must demonstrate < 2 g of protein/24 hour (hr) to allow participation in the studyXx_NEWLINE_xXThe patient’s urinary protein is =< 1 positive (+) (=< 30-100 mg/dl) on dipstick or routine urinalysis (urinary analysis [UA]; if urine dipstick or routine analysis is >= 2+ (>=100-300 mg/dl), a 24-hour urine collection for protein must demonstrate < 1000 mg of protein in 24 hours to allow participation in this protocol)Xx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXProteinuria > 100 mg/dl on urine analysisXx_NEWLINE_xXUrinalysis: for patients with 2+ proteinuria on urinalysis, 24 hour urine collection should be obtained; 24 hour urine protein should be < 2 gramsXx_NEWLINE_xXPHASE I STUDY ELIGIBILITY CRITERIA:\r\nSpot urine protein/creatinine ratio =< 1 OR 24 hour urine protein =< 1000 mgXx_NEWLINE_xXPHASE II STUDY COHORT 1 OVARIAN CANCER ELIGIBILITY CRITERIA (MEDI+O, MEDI+C AND MEDI+O+C): For OvCa MEDI+C and MEDI+O+C arms only: \r\nSpot urine protein/creatinine ratio =< 1 OR 24 hour urine protein =< 1000 mgXx_NEWLINE_xXPHASE II COLORECTAL CANCER COHORT 6 (MEDI+C ONLY):\r\nSpot urine protein/creatinine ratio =< 1 OR 24 hour urine protein =< 1000 mgXx_NEWLINE_xXProteinuria =< grade 1 (ie, =< 1+ [30 mg/dL] using a random urine sample or < 1.0 gm using a 24-hour sample)\r\n* Note: if urine sample indicates >= grade 2 proteinuria (ie, 2+ [100 mg/dL]), a 24-hour urine sample must be collected and tested; urine protein in the 24-hour sample must be < 1.0 gm/24 hoursXx_NEWLINE_xXUrine protein: creatinine ratio (UPC) of =< 1 or less than or equal to 2+ proteinuria on two consecutive dipsticks taken no less than 1 week apart; UPC is the preferred test; patients with >= 2+ proteinuria on dipstick must also have a 24 hour urine collection demonstrating =< 500 mg over 24 hoursXx_NEWLINE_xXUrine dipstick for proteinuria < 2+; patients discovered to have >= 2+ proteinuria on dipstick should undergo a 24-hour urine collection and demonstrate =< 1g of protein in 24 hoursXx_NEWLINE_xXUrine M protein ? 200 mg/24 hours), orXx_NEWLINE_xXWithin 4 days prior to the first dose of cabozantinib: Urine protein/creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXUrine protein < 2+Xx_NEWLINE_xXIf urinalysis shows proteinuria, 24 hour urine collection is to be performed and the 24 hour urine protein is to be < 2 grams to be eligibleXx_NEWLINE_xXPatients who have proteinuria at baseline; patients who are unexpectedly discovered to have >= grade 2 proteinuria at baseline routine urinalysis should undergo a 24-hour urine collection, which must be an adequate collection and must demonstrate =< 1 g of protein/24 hour (hr) to allow participation in the studyXx_NEWLINE_xXUrine protein creatinine (UPC) < 1 or, if UPC >= 1, 24-hour urine protein < 1 g; use of urine dipstick for renal function assessment is not acceptableXx_NEWLINE_xXUrine protein should be screened by dipstick or urine analysis; for proteinuria > 1+ or urine protein: creatinine ratio > 1.0, 24-hour urine protein should be obtained and the level should be < 2000 mg for patient enrollmentXx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXUrine protein creatinine ratio as determined by urinalysis of < 0.5 (for urine protein creatinine ratio of > 0.5, 24-h urine protein must have been < 1 gram)Xx_NEWLINE_xXProteinuria as demonstrated by: \r\n* Urine protein: creatinine (UPC) ratio >= 1.0 at screening OR \r\n* Urine dipstick for proteinuria >= 2+ (patients discovered to have >= 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligible)Xx_NEWLINE_xXUrine M-protein =< 1 g/24 hours (MM patients only)Xx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXUrine protein:creatinine ratio >= 1.0 at screeningXx_NEWLINE_xXUrine protein : creatinine ratio >= 1.0 at screeningXx_NEWLINE_xXUrine for proteinuria should be < 2 +; patients discovered to have >= 2 + proteinuria on dipstick urinalysis at baseline should undergo a 24-hour urine collection and must demonstrate < 1 g of protein in 24 hoursXx_NEWLINE_xXIn patients with metastatic pheochromocytoma, screening urinalysis required prior to study enrollment; if random collection urine specimen is positive for proteinuria, patients must have 24-hour urine protein determination; patients with metastatic pheochromocytoma are excluded if 24-hour urine protein is above the institutional upper limit of normalXx_NEWLINE_xXUrine protein to creatinine ratio (UPC) < 1; if UPC >= 1, then a 24-hour urine protein must be assessed; subjects must have a 24-hour urine protein value < 1 g to be eligible; use of urine dipstick for renal function assessment is not acceptableXx_NEWLINE_xXOr 24-hour urine protein < 1 gXx_NEWLINE_xXUrine protein should be screened by urine analysis; if protein is 2+ or higher, 24-hour urine protein should be obtained; patients with 24-hour urine protein >= 1000 mg are excludedXx_NEWLINE_xXUrine protein < 1+ on dipstick test or routine urinalysis; if the proteinuria on these tests is >= 2+, then a 24-hour urine test must be collected and must demonstrate < 1 g protein in 24 hours to allow participationXx_NEWLINE_xXProteinuria as demonstrated by:\r\n* Urine protein: creatinine (UPC) ratio >= 1.0 at screening (patients discovered to have a UPC >= 1 should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligible) OR\r\n* Urine dipstick for proteinuria >= 2+ (patients discovered to have >= 2+ proteinuria on dipstick urinalysis may either undergo urine protein: creatinine (UPC) testing, and may participate if ratio < 1. 0 or should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligible)Xx_NEWLINE_xXIf there is proteinuria present on dipstick, patients must have a 24 hour urine collection; patients are excluded if they have > 500 mg protein on 24 hour urine collectionXx_NEWLINE_xXUrinary protein < 2+ by urine dipstick (if >= 2+, a 24-hour urine protein must show protein < 2 g per 24 hours)Xx_NEWLINE_xXProteinuria at screening as demonstrated by either urine protein: urine protein creatinine (UPC) ratio >= 1.0 or 24hr collection > 1g/24hr at screeningXx_NEWLINE_xXurine M-protein ?200 mg/24 hours.Xx_NEWLINE_xXUrine M-protein ?200 mg/24 hours, ORXx_NEWLINE_xXurine M-protein ? 200 mg/24 hours,Xx_NEWLINE_xXUrinary protein >2+ possibly indicative of renal disease. If the 24 hours urine protein shows a result of < 100 mg protein, subject can be eligible;Xx_NEWLINE_xXUrine protein to creatinine ratio (UPC) < 1; NOTE: if UPC >= 1, then a 24-hour urine protein must be assessed; subjects must have a 24-hour urine protein value < 1 g to be eligibleXx_NEWLINE_xXUrine M-protein ? 200 mg/24hXx_NEWLINE_xXUrine protein =< 1+ or urine protein to creatinine ratio =< 1; if urine protein:creatinine (UPC) ratio is > 1 on urinalysis, then 24-hour urine collection from protein must be obtained and level must be < 1,000 mg for patient enrollmentXx_NEWLINE_xXUrine dipstick proteinuria >= 2+ or nephrotic range proteinuria on >= 2 gram in 24-hour urineXx_NEWLINE_xXWithin 7 days before the first dose of cabozantinib: Urine protein/creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXUrine for proteinuria should be < 2 +; patients discovered to have >= 2 + proteinuria on dipstick urinalysis at baseline should undergo a 24?hour urine collection and must demonstrate < 1 g of protein in 24 hoursXx_NEWLINE_xXPersistent proteinuria >= grade 3 NCI-CTCAE v4.0 (> 3.5 g/24 hrs, measured by urine protein:creatinine ratio on a random urine sample)Xx_NEWLINE_xXUrine dipstick proteinuria < 2+ or urine protein/creatinine (UPC) ratio =< 1.0; Note: patients discovered to have >= 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24-hour urine collection and must demonstrate =< 1 g of protein in 24 hoursXx_NEWLINE_xXUrine protein:creatinine ratio (UPC) =< 45 mg/mmol; ONLY APPLICABLE for patients with NF2 mutation (GSK2256098)Xx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXProteinuria =< 2+ (100 mg/dL) using a random urine sample or < 3.0 gm using a 24-hour sample; Note: If urine sample indicates >= 2+ [100 mg/dL]), a 24-hour urine sample must be collected and tested; urine protein in the 24-hour sample must be < 3.0 gm/24 hoursXx_NEWLINE_xXUrine monoclonal protein >200 mg/24 hourXx_NEWLINE_xXUrine M protein ? 200 mg/24 hoursXx_NEWLINE_xXWithin 28 days prior to administration of therapy: Proteinuria - urine protein:creatinine ratio (UPC) of =< 1 OR =< 2+ proteinuria on two consecutive urinalysis/dipstick tests taken no less than 1 week apart; patients with 2+ proteinuria on dipstick must also have a UPC of =< 0.5 on 2 consecutive samplesXx_NEWLINE_xXUrine protein: creatinine ratio (UPC) of =< 1; UPC is the preferred testXx_NEWLINE_xXProteinuria of CTCAE grade 3 or higher (estimated by urine protein: creatinine ratio >= 3.5 on a random urine sample); patients who recently (i.e., at least 30 days prior to registration) discontinued an anti-angiogenic therapy which caused proteinuria (ie, grade 2 (> 2 to > 3 g of protein or 1-3.5 g/24 hours [h]) or grade 3 proteinuria (> 4 of protein or > 3.5 g/24 h) are not eligible for enrollment until proteinuria improves to < 2 g of protein per 24 hXx_NEWLINE_xXUrine protein: creatinine ratio urine protein creatinine (UPC) of =< 1 OR less than or equal to 2+ proteinuria on two consecutive dipsticks taken no less than 1 week apart; UPC is the preferred test; patients with 2+ proteinuria on dipstick must also have a 24-hour urine collection demonstrating protein of =< 500 mg over 24 hoursXx_NEWLINE_xXMeasurable level of M-protein > 1 g/dL on serum protein electrophoresis or > 200 mg of M-protein on a 24 hour urine protein electrophoresisXx_NEWLINE_xXUrine protein-creatinine ratio (UPCR) =< 1 on spot urinalysis or protein =< 500 mg/24 hour urineXx_NEWLINE_xXAbsence of proteinuria at screening as demonstrated by one of the following:\r\n* Urine protein/creatinine (UPC) ratio < 1.0 at screening OR\r\n* Urine dipstick for proteinuria < 2+ (patients discovered to have >= 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligible)Xx_NEWLINE_xXProteinuria at Screening. Subjects with a urine dipstick protein ?2+ at Screening should undergo a 24-hour urine collection and must demonstrate ?1g of protein in 24 hours to be eligibleXx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXProteinuria >= grade 3 (> 3.5 g/24 hours, measured by urine protein: creatinine ratio on a random urine sample)Xx_NEWLINE_xXProteinuria: if urine dipstick shows 2+ protein, 24 hour urinary protein should be done and be less than =< 2 grams/24 hoursXx_NEWLINE_xXProteinuria (>= 2 g/24 hours)Xx_NEWLINE_xXUrine protein should be screened by urinalysis; if protein is 2+ or higher, 24 hour urine protein should be obtained and the level should be < 1000 mg for patient enrollmentXx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 1; if urine/protein creatinine (UPC) >= 1, then a 24-hour urine protein must be assessed; eligible patients must have a 24-hour urine protein value < 1 g/LXx_NEWLINE_xXUrine protein/creatinine ratio < 1 or 24-hour urine < 1 gramXx_NEWLINE_xXSpot urine protein to creatinine ratio (UPCR) < 1 or a 24-hour urine protein collection < 1 gm within 10 days prior to registrationXx_NEWLINE_xXUrine protein should be screened by dipstick analysis; if protein >= 2+ on dipstick, then urine protein creatinine (UPC) ratio should be calculated; if UPC ratio > 0.5, 24-hour urine protein should be obtained and the level should be < 1000 mg/24 hours for patient enrollmentXx_NEWLINE_xXUrine protein must be screened by urine analysis within 28 days prior to registration; patient must not have greater than +1 proteinuria on two consecutive dipsticks taken no less than 7 days apart; however, if the first urinalysis shows no protein, then a repeat urinalysis is not requiredXx_NEWLINE_xXPatients with clinically significant proteinuria (urine protein creatinine ratio greater or equal to 1.0)Xx_NEWLINE_xXProteinuria at screening as demonstrated by either:\r\n* Urine protein:creatinine (UPC) ratio >= 1.0 at screening OR\r\n* Urine dipstick for proteinuria > 2+ (patients discovered to have > 2+ proteinuria on dipstick urinalysis at baseline must have a UPC ratio done that is < 1.0 to be eligible; if the UPC ratio is >= 1.0 then the patient should undergo a 24-hour urine collection which must demonstrate =< 1 g of protein in 24 hours for the patient to be eligible)Xx_NEWLINE_xXPatients must have measurable levels of monoclonal protein (M-protein): >= 1g/dL on serum protein electrophoresis or >= 200 mg of monoclonal protein on a 24 hour urine protein electrophoresis which must be obtained within 4 weeks prior to randomizationXx_NEWLINE_xXUrinary protein is <2+.Xx_NEWLINE_xXUrine protein/creatinine (UPC) ratio < 0.5 or urine protein =< 1+ on dipstick or routine urinalysis (UA); if UPC >= 0.5 or urine dipstick or routine analysis is >= 2+, a 24-hour urine collection for protein must demonstrate < 1,000 mg of protein in 24 hours to allow participation in the studyXx_NEWLINE_xXUrine protein/creatinine ratio =< 1 (or protein =< 1+ on urinalysis or 24 hour urine protein =< 1 gram/24 hours)Xx_NEWLINE_xXUrine protein to urine creatinine ratio (UPC) should be less than 1; if greater than 1, then 24 hour urine protein must be less than 1 g for patient to be eligibleXx_NEWLINE_xXPatients whose urinary protein is =< 1+ on a dipstick or routine urinalysis (UA); if routine analysis is > 2+, a 24-hour urine collection for protein must demonstrate < 1000 mg of protein in 24 hours to allow participation in this protocol)Xx_NEWLINE_xXSubjects must have a urine protein/creatinine (UPC) ratio < 1; if UPC >= 1, then a 24-hour urine total protein must be obtained; subjects must have a 24-hour urine protein value < 1 g to be eligible; use of urine dipstick for renal function assessment is not acceptableXx_NEWLINE_xXHave urinary protein ?1+ on dipstick or routine urinalysis.Xx_NEWLINE_xXUrine protein creatinine (UPC) < 1 (in like units) or, if UPC >= 1, 24-hour urine protein < 1 g; use of urine dipstick for renal function assessment is not acceptableXx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXUrine M-protein ?200 mg/24 hrsXx_NEWLINE_xXUrine protein creatinine (UPC) ratio < 1 OR urine protein =< 1+Xx_NEWLINE_xXMonoclonal protein present in the serum and/or urineXx_NEWLINE_xXIgG MM: Serum monoclonal paraprotein (M-protein) level ? 1.0 g/dl or urine Mprotein level ? 200 mg/24 hours- IgA MM: Serum M-protein level ? 0.5 g/dl or urine M-protein level ? 200 mg/24 hoursXx_NEWLINE_xXIgM MM (IgM M-protein plus lytic bone disease documented by skeletal survey plain films): Serum M-protein level ? 1.0 g/dl or urine M-protein level ? 200 mg/24 hoursXx_NEWLINE_xXIgD MM: Serum M-protein level ? 0.05 g/dl or urine M-protein level ? 200 mg/24 hoursXx_NEWLINE_xXParticipants having > 1 + proteinuria on urine dipstick testing will undergo 24 hour urine collection for quantitative assessment of proteinuria. Participants with urine protein ? 1 gram/24 hours will be ineligible.Xx_NEWLINE_xXUrine M protein ?200 mg/24 hours;Xx_NEWLINE_xXCreatinine ? 1.5 x ULN or 24-hour urine < Grade 2Xx_NEWLINE_xXUrine protein/creatinine ratio >= 1.0Xx_NEWLINE_xXPatients are excluded if they have proteinuria at screening as demonstrated by either:\r\n* Urine dipstick for proteinuria >= 2+ (patients discovered to have >= 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligible) OR\r\n* Urine protein: creatinine (UPC) ratio >= 1.0 at screening; for UPC ratio > 1, a 24 hour urine protein should be obtained and the level should be < 1000mg; NOTE: urine protein should be screened by urine analysis for UPC ratio; a UPC ratio of 1 is roughly equivalent to a 24-hour urine protein of 1 gXx_NEWLINE_xXUrinalysis dipstick for urinary protein performed within 28 days prior to randomization must be 0-1+ protein. If urine dipstick result is greater than or equal to 2+ protein, a 24-hour urine protein must be less than 1.0 g/24 hours.Xx_NEWLINE_xXUrine monoclonal protein (UPEP) ?200 mg by 24 hour urine.Xx_NEWLINE_xXMust have measurable disease (serum M-protein or urine M-protein).Xx_NEWLINE_xXUrine protein: creatinine ratio ? 1.0 at screeningXx_NEWLINE_xXHave persistent 2+ protein by urinalysis (patients with 2+ proteinuria that have a spot protein:creatinine ratio of less than 0.3 may be enrolled) or a history of nephrotic syndrome.Xx_NEWLINE_xX?200 mg of monoclonal protein in the urine on 24-hour electrophoresisXx_NEWLINE_xXMeasurable levels of myeloma paraprotein (M-protein) in serum (> 0.5 g/dL) or urine (> 0.2 g excreted in a 24-hour collection sample).Xx_NEWLINE_xXProteinuria, as demonstrated by urine dipstick or > 1.0 g of protein in a 24-hour urine collection; all patients with >= 2+ protein on dipstick urinalysis at baseline must undergo a 24-hour urine collection for proteinXx_NEWLINE_xXPatients must have a documented diagnosis of multiple myeloma with evidence of measurable disease i.e. serum M protein superior or equal to 0.5 g per dL measured using serum protein immunoelectrophoresis and or urine M protein superior or equal to 200 mg per 24 hours measured using urine protein immunoelectrophoresis.Xx_NEWLINE_xXPatients with urine dipstick for proteinuria > 2+; patients with >= 2+ proteinuria on baseline dipstick analysis should undergo a 24-hour urine collection and must demonstrate =< 1 g of protein in the 24-hour urine; alternatively, proteinuria testing can be performed according to local standardsXx_NEWLINE_xXPersistent proteinuria ? Grade 3 NCI-CTCAE v4.03 (> 3.5 g/24 hrs, measured by urine protein: creatinine ratio on a random urine sample).Xx_NEWLINE_xXUrine protein/creatinine (UPC) ratio < 1.0 within 14 days prior to registration; if the UPC ratio is >= 1.0 then the patients should undergo a 24-hour urine collection and must demonstrate =< 1g of protein in 24 hours to be eligible)Xx_NEWLINE_xXProteinuria at screening demonstrated by urine analysis (UA) > 1+ and 24 hour urine protein >= 1 gram/24 hoursXx_NEWLINE_xXSubjects having greater than 1+ proteinuria on urine dipstick testing will undergo a 24-hour urine collection for quantitative assessment of proteinuria. Subjects with a urine protein greater than or equal to 1 g/24 hours will be ineligible.Xx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 2Xx_NEWLINE_xXUrine protein:creatinine ratio =< 1.0 at screeningXx_NEWLINE_xXUrine protein (albumin)/creatinine ratio of < 1.0Xx_NEWLINE_xXParticipant's urinary protein is ? 1+ on dipstick or routine urinalysis (UA); if urine protein ? 2+, a 24-hour urine collection must demonstrate < 1000 milligrams (mg) of protein in 24 hours to allow participation in the studyXx_NEWLINE_xXPersistent renal involvement from diagnosis with proteinuria (predominantly albumin) > 500mg/day in a 24-hour urine collectionXx_NEWLINE_xXUrine protein must be screened by urinalysis; if protein is 2+ or higher, 24-hour urine protein should be obtained and the level should be < 1000 mg for patient enrollmentXx_NEWLINE_xXGrade 2 or higher proteinuria (2+ or higher protein on urinalysis or urine protein:creatinine (UPC) ratio >= 1.0; if both tests are performed, UPC should be used to evaluate eligibility) or hematuriaXx_NEWLINE_xXKnown proteinuria defined by >= 2+ protein by urinalysis (UA) or >= 1 gram protein by 24 hour urine collection; Note: Subjects that are >= 2+ or greater on dipstick but < 1 g protein on 24 hour urine ARE eligible to participateXx_NEWLINE_xXUrinalysis =< 1+ proteinXx_NEWLINE_xXUrine protein =< 1+ on urine dipstick (if 2+ seen on first test, re-test at least 24 hours later), within 14 days of study registrationXx_NEWLINE_xXClinically significant proteinuria: \r\n* Subjects having > 1+ proteinuria on urinalysis will undergo 24-hour urine collection for quantitative assessment of proteinuria; subjects with urine protein >= 1 g/24-hour will be ineligibleXx_NEWLINE_xXWithin the past 4 weeks: Urine monoclonal protein > 200 mg/24 hourXx_NEWLINE_xXUrinary protein is <2+ on dipstick or routine urinalysis.Xx_NEWLINE_xXUrine M-protein ? 200 mg/24 hoursXx_NEWLINE_xXUrine protein-to-creatinine (UPC) ratio =< 2 mg/mg or 24-hour urine protein < 2 gXx_NEWLINE_xXPersistent proteinuria >= grade 3 NCI-CTCAE v4.0 (> 3.5 g/24 hrs, measured by urine protein:creatinine ratio on a random urine sample)Xx_NEWLINE_xXProteinuria less than or equal to 1+ proteinuria on two consecutive dipsticks taken no less than week apart, or a urine protein:creatinine (UPC) ration of =< 1Xx_NEWLINE_xXHas greater than 1+ proteinuria on a urine dipstick or equivalent routine laboratory analysis will require further testing with a urine protein to creatinine ratio (UPCR); if the UPCR >= 1, then the patient will not be eligible for study entry; however, if urinalysis or equivalent routine laboratory analysis shows no protein, then UPCR testing is not requiredXx_NEWLINE_xXThe urine protein: creatinine ratio (UPCR) is derived as follows: protein concentration (mg/dL)/creatinine (mg/dL); patients must have a UPCR < 1.0 to allow participation in the studyXx_NEWLINE_xXUrinary protein =< 1+ obtained =<14 days prior to randomization\r\n* Patients discovered to have >= 2+ proteinuria must have a spot urine protein:creatinine ratio (UPCR) < 1.0Xx_NEWLINE_xXPatients with proteinuria (3+ on dipstick or 300 mg/dL on urine analysis or > 500 mg/dL/24 hours)Xx_NEWLINE_xXPersistent proteinuria grade 2 or higher measured by urine protein:creatinine ratio on a urine sample or during 24-hour assessmentXx_NEWLINE_xXUrine dipstick for proteinuria < 2+ (patients discovered to have >= 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate =< 1g of protein in 24 hours to be eligible)Xx_NEWLINE_xXUrinary protein =< 2+ by urine analysis; if urine protein is > 2+ then a 24-hour urine collection can be done and the patient may enter only if urinary protein is < 2 g per 24 hoursXx_NEWLINE_xXUrine protein creatinine (UPC) ratio must be < 1.0 gmXx_NEWLINE_xXIf UPCR ratio >= 1, collection of 24-hour urine measurement of urine protein is recommendedXx_NEWLINE_xXPersistent proteinuria >= grade 3 NCI-CTCAE v4.0 (> 3.5 g/24 hours [hrs], measured by urine protein:creatinine ratio on a random urine sample)Xx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 2Xx_NEWLINE_xXUrine M-protein ? 200 mg/24 hXx_NEWLINE_xXCreatinine clearance >= 40 ml/min (estimated or measured creatinine clearance) or serum creatinine =< 1.6 mg/dl\r\n* Random urine protein < 20 mg/dL; if >= 20 mg/dL then a 24-hour urine protein collection will be performed to accurately demonstrate that the 24-hour total is < 1000 mg, the level acceptable for enrollment on studyXx_NEWLINE_xXUrine protein to creatinine ratio (UPC) < 1 (tested within 14 days prior to registration)\r\n* If UPC >= 1, then a 24-hour urine protein must be assessed; subjects must have a 24-hour urine protein value < 1 g to be eligible; use of urine dipstick for renal function assessment is not acceptableXx_NEWLINE_xX24-hour urine protein, if required < 1 g (tested within 14 days prior to registration)\r\n* If UPC >= 1, then a 24-hour urine protein must be assessed; subjects must have a 24-hour urine protein value < 1 g to be eligible; use of urine dipstick for renal function assessment is not acceptableXx_NEWLINE_xXPalliative radiation that does not include a target lesion is allowed. Subjects having a spot urine protein:creatinine ratio of > 1 will undergo 24-hour collection for quantitative assessment of proteinuria. If urine protein > 1 gram/24 hours, the subject will be ineligibleXx_NEWLINE_xXRelapsed and/or refractory multiple myeloma with measurable disease, as defined by one or both of the following (assessed within 14 days prior to initiation of therapy): a) serum myeloma protein (M-protein) >= 0.5 g/d; b) urine Bence-Jones protein >= 200 mg/24 hoursXx_NEWLINE_xXUrine protein to creatinine ratio of < 1 prior to registrationXx_NEWLINE_xXPatients must not have baseline proteinuria within 14 days prior to registration as demonstrated by either:\r\n* Urine protein: creatinine (UPC) ratio < 1.0 at screening, OR\r\n* Urine dipstick for proteinuria =< 2+; NOTE: patients discovered to have >= 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligibleXx_NEWLINE_xXProteinuria < 3 + by urinalysis or urine dipstickXx_NEWLINE_xXSubjects having greater than 1+ proteinuria on urine dipstick testing will undergo 24-hour urine collection for quantitative assessment of proteinuria. Subjects with urine protein greater than or equal to 1 g/24-hour will be ineligible.Xx_NEWLINE_xXUrine protein to creatinine ratio < 1, or, 24-hour urine protein < 1 g; if urine protein to creatinine (UPC) >= 1, then a 24-hour urine protein must be assessed; patients must have a 24-hour urine protein value < 1 g to be eligible; use of urine dipstick for renal function assessment is not acceptableXx_NEWLINE_xXUrine protein: creatinine ratio > 1Xx_NEWLINE_xXUrine protein to creatinine ratio (UPC) < 1\r\n* Or, 24-hour urine protein < 1 g\r\n* If UPC >= 1, then a 24-hour urine protein must be assessed; subjects must have a 24-hour urine protein value < 1 g to be eligibleXx_NEWLINE_xXUrine protein =< 1+ on dipstick or routine urinalysis; if urine dipstick or routine urinalysis indicates proteinuria >= 2+, then a 24-hour urine must be collected and must demonstrate < 100 mg of protein in 24 hoursXx_NEWLINE_xXUrine protein =< 1+ OR urine protein to creatinine (UPC) ratio =< 1; if UPC ratio is > 1 on urinalysis, then 24-hour urine collection for protein must be obtained and level must be < 1,000 mg for patient enrollmentXx_NEWLINE_xXUrine protein should be screened by urine analysis for urine protein creatinine (UPC) ratio; for UPC ratio > 0.5, 24-hour urine protein should be obtained and the level should be < 1000 mg for patient enrollment; NOTE: UPC ratio of spot urine is an estimation of the 24-urine protein excretion; a UPC ratio of 1 is roughly equivalent to a 24-hour urine protein of 1 gmXx_NEWLINE_xXUrine protein: creatinine (UPC) ratio < 1.0 within 14 days prior to registration OR urine dipstick for proteinuria =< 2 positive (+) (patients discovered to have > 2+ proteinuria on dipstick urinalysis at baseline must have a UPC ratio done that is < 1.0 to be eligible; if the UPC ratio is >= 1.0 then the patients should undergo a 24-hour urine collection and must demonstrate =< 1g of protein in 24 hours to be eligible)\r\n* Note: UPC ratio of spot urine is an estimation of the 24-hour urine protein excretion; a UPC ratio of 1 is roughly equivalent to a 24-hour urine protein of 1 gmXx_NEWLINE_xXUrine protein to creatinine ratio (UPC) < 1; if UPC >= 1, then a 24-hour urine protein must be assessed; patients must have a 24-hour urine protein value < 1 g to be eligibleXx_NEWLINE_xXUrine protein/urine creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXUrinary protein =< 100 mg/dL in urinalysis or =< 1+ on dipstick, unless quantitative protein is < 1000 mg in a 24 h urine sampleXx_NEWLINE_xXUrinalysis urine protein:creatinine ratio (UPCR) < 1 or < 1000 mg protein/24 hour (hr)Xx_NEWLINE_xXUrine dipstick for proteinuria < 2+; patients with < 2+ proteinuria on baseline dipstick analysis should undergo a 24-hour urine collection and must demonstrate =< 1 g of protein in the 24-hour urine; alternatively, proteinuria testing can be performed according to local standardsXx_NEWLINE_xXUrine Protein Creatinine (UPC) ratio < 1.0 or 24 hour urine protein ratio < 1000 mgXx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXUrine protein to creatinine ratio < 1; or, 24-hour urine protein < 1 g; if urine protein creatinine ratio (UPC) >= 1, then a 24-hour urine protein must be assessed; subjects must have a 24-hour urine protein value < 1 g to be eligible; use of urine dipstick for renal function assessment is not acceptableXx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXUrine M-protein ? 200 mg/24 hours.Xx_NEWLINE_xXUrine protein to creatinine ratio (UPC) < 1; if UPC >= 1, then a 24-hour urine protein must be assessed; subjects must have a 24-hour urine protein value < 1 g to be eligibleXx_NEWLINE_xXUrine dipstick proteinuria < 2+ or urine protein/creatinine (UPC) ratio =< 1.0 obtained =< 14 days prior to randomization\r\n* Note: patients discovered to have >= 2 + proteinuria on dipstick urinalysis at baseline should undergo a 24-hour urine collection and must demonstrate =< 1 g of protein in 24 hoursXx_NEWLINE_xXProteinuria: patients are allowed to have 0, trace, or 1+ protein by urine dipstick or urinalysis to enroll, if >= 2+ must check 24 hour (h) urine protein and must be < 1g to start studyXx_NEWLINE_xXUrine protein to creatinine ratio (UPCR): < 1.0Xx_NEWLINE_xXUrinary protein < 2+ (unless total quantitative protein is < 500 mg protein/day as determined by 24 hour [H] urine collection)Xx_NEWLINE_xXPatients with proteinuria > 1+ on urine dipstick or urine protein creatinine (UPC) ratio >= 1 at screening; if > 1+ proteinuria is detected on surveillance, a 24-hour collection must be performed if eligibility is desired; patients with a 24-hour urine protein content of =< 500 mg are eligibleXx_NEWLINE_xXWithin 14 days prior to registration: Urine protein/creatinine ratio should be =< 1Xx_NEWLINE_xXQuantitative urine protein by dipstick =< 100Xx_NEWLINE_xXUrine protein to creatinine ratio (UPC) =< 1; a UPC is required only if the urine protein is > 100; if UPC >1, then a 24-hour urine protein must be assessed; subjects must have a 24-hour urine protein value < 1 g to be eligibleXx_NEWLINE_xXUrine protein:creatinine ratio of < 1Xx_NEWLINE_xXUrine M-protein ? 200 mg/24 hoursXx_NEWLINE_xXSubjects with a urine protein/creatinine ratio greater than 1Xx_NEWLINE_xXUrine protein to creatinine ratio (UPC) < 1Xx_NEWLINE_xXUrine protein to creatinine (UPC) ratio of < 1 assessed in a random or spot urine sample; if UPC >= 1, then a 24-hour urine protein must be assessed; patients must have a 24-hour urine protein value < 1 gram to be eligibleXx_NEWLINE_xXPatients with proteinuria on screening urinalysis confirmed to be > 1 g/24 hr by 24 hour urine collectionXx_NEWLINE_xXProteinuria as demonstrated by a urine protein: creatinine (UPC) ratio >= 1.0 at screeningXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or calculated creatinine clearance (CrCl) >= 40 cc/min and random urine protein:creatinine ratio (UPC) < 1 or 24-hour (hr) urine protein < 1 g, within 14 days of registrationXx_NEWLINE_xXUrine protein to creatinine ratio (UPC) < 1 (note, if >= 1, then a 24-hour urine protein must be assessed: if 24-hour urine protein > 1 g, patient ineligible)Xx_NEWLINE_xXPatients with greater than 1+ proteinuria on a urine dipstick or equivalent routine laboratory analysis will require further testing with a urine protein to creatinine ratio (UPCR); UPCR must be calculated as follows: UPCR = protein concentration (mg/dL)/creatinine (mg/dL); if the UPCR >= 1 then the patient will not be eligible for study entry; however, if urinalysis or equivalent routine laboratory analysis shows no protein, then UPC testing is not requiredXx_NEWLINE_xXUrinary protein < 2+ by urine dipstick; if dipstick is >= 2+ then a 24-hour urine collection can be done and the patient may enter only if urinary protein is < 2 g per 24 hoursXx_NEWLINE_xXSpot urine must not show 1+ or more protein in urine or the patient will require a repeat urinalysis; if repeat urinalysis shows 1+ protein or more, a 24-hour urine collection will be required and must show total protein excretion < 1000 mg/24 hoursXx_NEWLINE_xXPatients must have a 24 hour (hr) urine collection showing less than 2000 mg of protein; EXCEPTION: patients with hematuria will be eligible with up to 3000 mg protein per 24 hours provided they do not have casts, eosinophiluria or electrolyte wastingXx_NEWLINE_xXUrine protein: creatinine ratio greater than or equal to 1.0Xx_NEWLINE_xXUrine protein to urine creatinine ratio (UPC) < 1.0; if UPC >= 1 then a 24 hour urine protein must be assessed; subjects must have a 24-hour urine protein value < 1 g to be eligibleXx_NEWLINE_xXEXPANSION COHORT ONLY: Urine protein to urine creatinine ratio (UPC) < 1.0; if UPC >= 1 then a 24 hour urine protein must be assessed; subjects must have a 24-hour urine protein value < 1 g to be eligibleXx_NEWLINE_xXTotal protein > 6.4Xx_NEWLINE_xXUrine protein: creatinine ratio >= 1.0 at screeningXx_NEWLINE_xXSpot urine must not show 1+ or more protein in urine or the subject will require a repeat urinalysis. If repeat urinalysis shows 1+ protein or more, a 24-hour urine collection will be required and must show total protein excretion <1,000 mg per 24 hours.Xx_NEWLINE_xXParticipants with urine protein ?1 gram/24 hourXx_NEWLINE_xXLess than or equal to 1+ proteinuria on two consecutive dipsticks taken no less than 1 week apart, OR < 1 gm protein on 24-hour urine collection or a urine protein: creatinine ratio of < 1Xx_NEWLINE_xXPatients with clinically significant proteinuria at screening as demonstrated by urine protein:creatinine (UPCR) ratio >/= 1.0 at screening. The UPCR has been found to correlate directly with the amount of protein excreted in a 24 hour urine collection. Specifically, a UPCR of 1.0 is equivalent to 1.0 gram of protein in a 24 hour urine collection. Obtain at least 4 ml of a random urine sample in a sterile container (does not have to be a 24 hour urine). Send sample to lab with request for urine protein and creatinine levels [separate requests].Xx_NEWLINE_xXUrine protein < 1+; if >= 1+, 24 hour urine protein should be obtained and should be < 1000 mgXx_NEWLINE_xXSignificant proteinuria: urinary protein/creatinine ratio >0.5 mg/mg in a non first void urine sampleXx_NEWLINE_xXEither urine protein < 1+ or measured 24 hour urine protein < 500 milligramXx_NEWLINE_xXContinued from Inclusion #8: Serum creatinine </= 1.5 ULN or creatinine clearance (CrCl) >/= 45 mL/min (CrCl = Wt (kg) x (140-age)/72 x Cr level, female x 0.85) for pts w/ creatinine levels above institutional normal; Amylase & lipase < 1.5 x the ULN; Urinalysis (UA) must show less than 1+ protein in urine, or the pt will require a repeat UA. If repeat UA shows 1+ protein or more, a 24 hour urine collection will be required & must show total protein </= 1000 mg/24 hour to be eligibleXx_NEWLINE_xXMeasurable disease M component in serum (? 0.5 g/dL) and/or urine (? 0.2 g excreted in a 24 hour collection sample)Xx_NEWLINE_xXPersistent proteinuria ? Grade 3 NCI CTCAE v4.0 as defined as > 3.5 g/24 hours, measured by urine protein: creatinine ratio on a random urine sample.Xx_NEWLINE_xXProteinuria =< grade 1+ or 24-hour protein =< 1000 mg for patients with proteinuria above 1+ or urine protein to creatinine ratio < 1.0Xx_NEWLINE_xXPatient’s with a history of kidney disease or persistent proteinuria must have < grade 3 proteinuria per NCI CTCAE v4.0 at screening; if a patient has a history of kidney disease or persistent proteinuria, a urine protein test will be performed on a random urine sample; if the result is normal then no additional testing is required; if the result is abnormal, a 24 hour urine will be collected to determine if proteinuria is < grade 3Xx_NEWLINE_xXPatient’s with a history of kidney disease or persistent proteinuria must have < grade 3 proteinuria per NCI CTCAE v4.0 at screening; if a patient has a history of kidney disease or persistent proteinuria, a urine protein test will be performed on a random urine sample; if the result is normal then no additional testing is required; if the result is abnormal, a 24 hour urine will be collected to determine if proteinuria is < grade 3Xx_NEWLINE_xXUrine M-protein ? 200 mg/24 hr, orXx_NEWLINE_xXPatient’s with a history of kidney disease or persistent proteinuria must have < grade 3 proteinuria per NCI CTCAE v 4.0 at screening; if a patient has a history of kidney disease or persistent proteinuria, a urine protein test will be performed on a random urine sample; if the result is normal then no additional testing is required; if the result is abnormal, a 24 hour urine will be collected to determine if proteinuria is < grade 3Xx_NEWLINE_xXUrine protein/creatinine < 1 mg/mgXx_NEWLINE_xXUrine protein < 1+; if >= 1+, 24 hour urine protein should be obtained and should be < 1000 mgXx_NEWLINE_xXProteinuria at Screening. Subjects with a urine dipstick protein ? 2+ at Screening will undergo a 24-hour urine collection and must demonstrate ? 1g of protein in 24 hours to be eligible.Xx_NEWLINE_xXUrine protein/creatinine (UPC) ratio =< 1.0 unless the patient has a neobladderXx_NEWLINE_xXUrine M-protein ? 200 mg/24 hXx_NEWLINE_xXUrine dipstick for proteinuria of =< less than 1+; if urine dipstick is > 1+ then a 24 hour urine for protein must demonstrate < 500 mg of protein in 24 hours to allow participation in the studyXx_NEWLINE_xXUPC ratio < 1.0 at screening or 24 hours urine protein < 1 gm (Appendix D)Xx_NEWLINE_xXProteinuria as defined as >= 2+ on urine dipstick; if dipstick urinalysis shows >= 2+ proteinuria, 24-hour urine for protein must be < 2 gramsXx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 2Xx_NEWLINE_xXUrine protein < 1+; or if >= 1+ then 24 hour urine protein should be obtained and should be < 1000 mgXx_NEWLINE_xXUrine monoclonal protein >200 mg on 24 hour electrophoresisXx_NEWLINE_xXRoutine urinalysis showing ?1+ protein or protein/creatinine ratio <0.5. For proteinuria ?2+ or urine protein/creatinine ratio ?0.5, 24-hour urine must be collected and the level must be <1 gram of protein in 24 hours for subject enrollment.Xx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXProteinuria at screening as demonstrated by urine dipstick >= 2+Xx_NEWLINE_xXUrine M-protein ? 200 mg/24 hours ORXx_NEWLINE_xXUrine protein:creatinine ratio =< 1.0 OR 24-hour urine protein =< 500 mg (24-hour total urine protein only need be obtained if urine protein:creatinine ratio < 1.0)Xx_NEWLINE_xXUrine protein-creatinine ratio (UPCR) > 1 urinalysis or total urine protein > 500 mg/24 hours (h)Xx_NEWLINE_xXDONOR: Creatinine clearance > 80 ml/minute as measured from a 24 hour urine collection within 26 weeks of the screening visit; if a serum creatinine drawn at the screening visit is > 20% higher than the serum creatinine drawn at the time of the 24 hour urine collection, the creatinine clearance must be re-evaluated by a repeat 24 hour urine test; if the new value is =< 80 mg/dL the donor will be excludedXx_NEWLINE_xXLess than or equal to 1+ proteinuria on two consecutive dipsticks taken no less than 1 week apart, or < 1 gm protein on 24-hour urine collection or a urine protein:creatinine ratio of < 1Xx_NEWLINE_xXUrine M-protein ? 200 mg/24 hours, orXx_NEWLINE_xXKidney: albuminuria ? 500 mg/day in a 24-hour urine specimenXx_NEWLINE_xXCrCl ? 30 mL/min as measured by 24-hour urineXx_NEWLINE_xXUrine Bence Jones protein ? 200 mg/24 hrXx_NEWLINE_xXUrine protein creatinine (UPC) ratio < 1; note: urine protein must be screened by urine analysis for UPC ratio; for UPC ratio >= 1.0, 24-hour urine protein must be obtained and the level should be < 1,000 mg for registrationXx_NEWLINE_xXHave persistent 2+ protein by urinalysis (patients with 2+ proteinuria that have a spot protein:creatinine ratio of less than 0.3 may be enrolled) or a history of nephrotic syndrome.Xx_NEWLINE_xXIf baseline urine protein creatinine (UPC) >= 1, a 24-hour urine protein must be assessed; patients must have a 24-hour urine protein value < grade 3 (> 3.5 g/24 hours) to be eligibleXx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 1Xx_NEWLINE_xXUrine protein/creatinine ratio (UPCR) =< 1 mg/mg (113.2 mg/mmol) creatinine or 24-hour (hr) urine protein of < 1 gXx_NEWLINE_xXGreater than 2+ proteinuria on two consecutive dipsticks taken no less than 1 week apart or 24-hour urine protein of > 1 g; patients with < 2+ proteinuria are eligible following initial determination by urinalysis within 1 week prior to enrollment and do not need the urinalysis repeatedXx_NEWLINE_xXPatient has proteinuria as demonstrated by urine protein:creatinine ratio ? 1.0 at screening or urine dipstick for proteinuria ? 2 (patients discovered to have ? 2 proteinuria on dipstick at baseline should undergo a 24-hour urine collection and must demonstrate < 2 g of protein in 24 hours to be eligible).Xx_NEWLINE_xXUrine M-protein ? 200 mg/24 hour, orXx_NEWLINE_xXUrinary protein =< 30 mg/dL in urinalysis or =< 1+ on dipstick, unless quantitative protein is < 1000 mg in a 24 h urine sampleXx_NEWLINE_xXUrine for proteinuria >= 2+ (patients discovered to have >= 2+ proteinuria on urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligible)Xx_NEWLINE_xXProteinuria, as demonstrated by a 24-hour protein of >= 2000 mg; urine protein will be screened by urine protein-creatinine ratio (UPC); for UPC ratio > 1.0, a 24-hour urine protein will need to be obtained and the level should be < 2000 mg for patient enrollmentXx_NEWLINE_xXUrine protein should be screened by urinalysis for urine protein creatinine ratio (UPCR); for UPCR > 1, a 24-hour urine protein should be obtained and the level should be < 500 mgXx_NEWLINE_xXHas urinary protein is ? 1+ on dipstick or routine urinalysis; if urine protein ? 2+, a 24-hour urine collection must demonstrate < 1000 mg of protein in 24 hours to allow participation in the studyXx_NEWLINE_xXUrine M protein ?200 mg per 24hrXx_NEWLINE_xXUrine M protein ?200 mg per 24hrXx_NEWLINE_xXPatients with clinically significant proteinuria; urine protein should be screened by urine protein-creatinine ratio (UPCR); patients must have a UPCR < 1.0 to allow participation in the studyXx_NEWLINE_xXUrine protein to creatinine (UPC) ratio < 1; if UPC >= 1, then a 24-hour urine protein must be assessed; subjects must have a 24-hour urine protein value < 1 g to be eligibleXx_NEWLINE_xXUrine Bence-Jones protein ? 200 mg/24 hoursXx_NEWLINE_xXProteinuria as defined by positive urine dipstick for protein OR urine protein/creatinine (UPC) ratio >= 1.0; if these criteria are not met, the patient must have a 24 hour urine collection that demonstrates < 1 gm protein over 24 hoursXx_NEWLINE_xXIf there is proteinuria present on dipstick, patients are excluded if they have > 500 mg protein on 24 hour urine collectionXx_NEWLINE_xXMonoclonal protein present in the serum and/or urineXx_NEWLINE_xXIgG multiple myeloma: Serum monoclonal paraprotein (M-protein) level ? 1.0 g/dl or urine M-protein level ? 200 mg/24 hoursXx_NEWLINE_xXIgA multiple myeloma: Serum M-protein level ? 0.5 g/dl or urine M-protein level ? 200 mg/24 hoursXx_NEWLINE_xXIgD multiple myeloma: Serum M-protein level ? 0.05 g/dl or urine M-protein level ? 200 mg/24 hoursXx_NEWLINE_xXProteinuria > 1+ on urine dipstick testing or 30 mg/dLXx_NEWLINE_xXUrinary M-protein excretion at least 200 mg/24 hours; orXx_NEWLINE_xXCreatinine less than or equal to 1.5 x ULN; if urine protein to creatinine ratio is greater than or equal to 1, a 24 hour urine protein must be assessed; subjects must have a 24 hour urine protein value less than 1 g to be eligible; use of urine dipstick for renal function assessment is not acceptableXx_NEWLINE_xXUrine to protein to creatinine (UPC) ratio < 1; if UPC > 1, then a 24-hour urine protein must be assessed; subjects must have a 24-hour urine protein value < 1 g to be eligibleXx_NEWLINE_xXUrine protein: urine protein:creatinine (UPC) ratio 1.0 OR urine dipstick for proteinuria: urine dipstick for proteinuria > 2+; patients discovered to have > 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligibleXx_NEWLINE_xXUrine protein to creatinine (UPC) ratio < 0.5 or if >= 0.5, 24-hour urine protein must be < 1000 mgXx_NEWLINE_xXParticipants having >1+ proteinuria on urine dipstick testing will undergo 24 hour urine collection for quantitative assessment of proteinuria. Participants with urine protein ?1 grams (g)/24 hours will be ineligible.Xx_NEWLINE_xXUrine protein: creatinine (UPC) ratio < 1.0 within 14 days prior to registration OR urine dipstick for proteinuria ? 2+ (patients discovered to have > 2+ proteinuria on dipstick urinalysis at baseline must have a UPC ratio done that is <1.0 to be eligible. If the UPC ratio is ? 1.0 then the patients should undergo a 24-hour urine collection and must demonstrate ? 1g of protein in 24 hours to be eligible). *Note: UPC ratio of spot urine is an estimation of the 24-hour urine protein excretion; a UPC ratio of 1 is roughly equivalent to a 24-hour urine protein of 1 gm. UPC ratio is calculated using one of the following formulas:Xx_NEWLINE_xX[urine protein]/[urine creatinine]: if both protein and creatinine are reported in mg/dLXx_NEWLINE_xX[(urine protein) x0.088]/[urine creatinine]: if urine creatinine is reported in mmol/LXx_NEWLINE_xXProteinuria, as demonstrated by > 1.5 gram of protein in a 24-hour urine collection; all patients with >= 2+ protein on dipstick urinalysis at baseline must undergo 24-hour urine collection for proteinXx_NEWLINE_xXHave normal urine analysis within 24 hours pre-surgeryXx_NEWLINE_xXProteinuria as demonstrated by a urine protein creatinine (UPC) ratio >= 1.0 at screeningXx_NEWLINE_xXProteinuria, as demonstrated by urine dipstick or > 1.0 g of protein in a 24-hour urine collectionXx_NEWLINE_xXUrinary protein is ?1+ on dipstick or routine urinalysis or 24-hour urine demonstrating <1 gram of protein.Xx_NEWLINE_xXMonoclonal protein present in the serum and/or urineXx_NEWLINE_xXHave detectable disease measured by a specific protein in your blood and/or urineXx_NEWLINE_xXTotal protein within 2 x ULNXx_NEWLINE_xXParticipants must have a 24-hour calcium concentration that is =< 300 mg/24 hours as measured by 24-hour urine collection at baselineXx_NEWLINE_xX- Proteinuria < 1 g/24 hours based upon 24 hour urine collection or spot urine protein/creatinine ratioXx_NEWLINE_xXUrine protein to creatinine ratio (UPC) < 1 (evaluated within 28 days of randomization); if UPC >= 1, then a 24-hour urine protein must be assessed; subjects must have a 24-hour urine protein value < 1g to be eligibleXx_NEWLINE_xXUrine protein should be screened by dipstick analysis; if protein >= 2+ on dipstick, then urine protein creatinine (UPC) ratio should be calculated; if UPC ratio > 1, 24-hour urine protein should be obtained and the level should be < 1000 mg/24 hours for patient enrollment; Note: UPC ratio of spot urine is an estimation of the 24 hour urine protein excretion- a UPC ratio of 1 is roughly equivalent to a 24-hour urine protein of 1 gmXx_NEWLINE_xXUrinary M-protein excretion at least 200 mg/24 hours; orXx_NEWLINE_xXPatients unwilling or unable to comply with the protocol, including providing 24-hour urine samples for urine protein electrophoresis at the required time points.Xx_NEWLINE_xXUrine protein =< 1+ on urine dipstick (if 2+ seen on first test, re-test at least 24 hours later) (within 14 days of study registration)Xx_NEWLINE_xXProteinuria > 1+ on dipstick urinalysis; patients with > 1+ proteinuria on dipstick urinalysis will undergo 24-hour urine collection for quantitative assessment; NOTE: patients with > 1 g/24 hours will be ineligibleXx_NEWLINE_xX- Proteinuria < 1 g/24 hours based upon 24 hour urine collection or spot urine protein/creatinine ratioXx_NEWLINE_xXC-reactive protein > 3 mg/LXx_NEWLINE_xXUrine M-protein >=200 mg/24 hours.Xx_NEWLINE_xXParticipants having >1+ proteinuria on urine dipstick testing will undergo 24-hour urine collection for quantitative assessment of proteinuria. Participants with urine protein ?1 g/24 h will be ineligible.Xx_NEWLINE_xX