Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 6 times upper limit of normal (ULN); obtained within 14 days prior to study entryXx_NEWLINE_xXAlanine aminotransferase ? 5 × upper limit of normal (ULN) for ageXx_NEWLINE_xXSerum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 1.5 x institutional upper limit of normal (IULN) within 28 days prior to registrationXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x institutional upper limit of normal (IULN) (or =< 5 x IULN if liver metastases are present)Xx_NEWLINE_xXSerum aspartate transaminase (aspartate aminotransferase [AST]) and serum alanine transaminase (alanine aminotransferase [ALT]) =< 2.5 x upper limit normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) both =< 5 x institutional upper limit of normal (IULN) within 14 days prior to step 2 randomizationXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 x upper limit of normal (ULN)Xx_NEWLINE_xXTransaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) =< 2.5 x institutional upper limit normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN); if liver metastases, =< 5 x upper limit of normal (ULN)Xx_NEWLINE_xXObtained =< 48 hours prior to registration: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 1.5 x the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x upper limits of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN), unless suspected leukemic involvement of the liverXx_NEWLINE_xXPatients must have aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 x institutional upper limit of normal (IULN) within 14 days prior to registrationXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 times institutional upper limit of normal with or without liver metastasis, within 21 days prior to study entryXx_NEWLINE_xXAspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate Aminotransferase (AST) ? 3.0x the upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT), aspartate aminotransferase (AST) no greater than 3.0 times the upper limit of normalXx_NEWLINE_xXHepatic: bilirubin <1.5 X Upper Limit of Normal (ULN); alkaline phosphatase (ALP), alanine aminotransferase (ALT) or aspartate aminotransferase (AST) < 5.0 X ULNXx_NEWLINE_xXSerum transaminases (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) less than three times the upper limits of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x institutional upper limit of normal for ageXx_NEWLINE_xXELIGIBILITY CRITERIA - PHASE I (ARMS A, B, C): Adequate liver function with aspartate aminotransferase (AST)/alanine aminotransferase (ALT) less than 3 X upper limit of normal and total bilirubin less than 2 mg/dL within 7 days prior to first dose of study agentXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 × upper limit of normal (ULN); if liver metastases, then < 5 × ULNXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN) or =< 5 x ULN if liver metastases are presentXx_NEWLINE_xXAspartate aminotransferase (AST) and Alanine aminotransferase (ALT) ? 3.0 x upper limit of normal (ULN)Xx_NEWLINE_xXPatients with aspartate aminotransferase (AST) =< 3 x upper limit of normalXx_NEWLINE_xXINCLUSION CRITERIA FOR SECOND-LINE THERAPY: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 X the upper normal limit of institution's normal rangeXx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 1.5 times the upper limit of normalXx_NEWLINE_xXSubject has a total bilirubin ? 1.5 x upper limit of normal (ULN), albumin ? 2.5 g/d, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) =< 2.5 times upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 2.5 x upper limit of normal if no documented liver disease or < 5 x upper limit of normal if documented liver diseaseXx_NEWLINE_xXalanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 5 times upper limit of normal as per local laboratory. Additional inclusion required for donor arm participants to proceed with transplantXx_NEWLINE_xXAspartate aminotransferase (AST) ? 1.5 x upper limits of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? 2.5 × upper limit of normal (ULN);Xx_NEWLINE_xXAspartate aminotransferase and alanine aminotransferase ?3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< upper limit of normal (ULN) in the absence of malignancy within the liver within 14 days of starting cycle 1 day 1 treatmentXx_NEWLINE_xXAspartate aminotransferase/alanine aminotransferase (AST/ALT) ?2.5 upper limit of normal (ULN).Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 × the upper limit of normal (ULN) (=< 5 × ULN if considered due to primary or metastatic liver involvement)Xx_NEWLINE_xXSerum alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase ?2 times the upper limit of normal (ULN); ? 5 times ULN if there is liver or bone involvement.Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x the ULN; for patients with documented liver metastases, AST/ALT =< 5.0 times the upper limit of normal, within 14 days before the first dose of cabozantinibXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 5 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 4 times the upper limit of normal (unless clinically considered to be related to liver involvement with leukemia)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal rangeXx_NEWLINE_xXAdequate hepatic function, with bilirubin < 2 times the upper limit of normal (ULN), and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 times ULNXx_NEWLINE_xXTREATMNET: Aspartate aminotransferase (AST) =< 3 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase/alanine aminotransferase (AST/ALT) ? 3 upper limit of normal (ULN). In cases with liver involvement ALT/ AST ? 5× ULN.Xx_NEWLINE_xXHave an alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level ?5 times upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 10 upper limit of normal (ULN) (unless elevated ALT/AST is attributed to leukemia or lymphoma involvement of the liver, in which case this criterion will be waived and not disqualify a patient)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than or equal to 3 x the upper limit of normalXx_NEWLINE_xXObtained =< 21 days prior to registration: alanine aminotransferase (ALT) =< 3 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) ? 3 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) > 5 times the upper limit of normal (ULN) or alanine aminotransferase (ALT) > 5 times ULNXx_NEWLINE_xXAspartate aminotransferase (AST) < 2 x institutional upper limit of normal (ULN) within 14 days of enrollment to trialXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 times the upper limit of normal; for patients with documented liver metastases, AST/ALT =< 5.0 times the upper limit of normalXx_NEWLINE_xXSerum AST and/or alanine aminotransferase (ALT) < 3 x institutional upper limit of normal (ULN).Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 times the upper limit of normalXx_NEWLINE_xXINCLUSION - INFUSION: Aspartate aminotransferase (AST) ? 5 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXHepatic: Total bilirubin < 3.0 x the upper limit of normal (ULN) for age (patients who have been diagnosed with Gilbert's Disease are allowed to exceed this limit) and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 5.0 x ULN for age.Xx_NEWLINE_xXTREATMENT INCLUSION: Aspartate aminotransferase (AST) 3 times or less than the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 3X upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 5 x upper limit normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) =< upper limit of institutional normalXx_NEWLINE_xXAspartate aminotransferase (AST) < 2 x upper normal limitXx_NEWLINE_xXAlanine aminotransferase (ALT) < 2 x upper normal limitXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (AST) and aspartate aminotransferase (ALT) ? 10 x upper limit of normal for ageXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x the institutional upper limit of normal (IULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 X institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2 x institutional upper limit of normal (IULN) except for Gilbert’s disease or when in the opinion of treating physician elevated levels are due to direct involvement of leukemia (e.g., hepatic infiltration or biliary obstruction due to leukemia), in which case ALT and AST may be elevated up to =< 5 x IULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) ?3.0 × the upper limit of normal(ULN), even in the presence of liver metastases.Xx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels ? 2.5 times upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT)/alkaline phosphatase: =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 2.5 times the upper limit of institutional normal (ULN)Xx_NEWLINE_xXPatients without underlying liver disease\r\n* Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 X institutional upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) > 2.5 x the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) ? 3 X upper limit of normalXx_NEWLINE_xXAlanine aminotransferase & Asparate aminotransferase ? 2.5 x upper limit or normalXx_NEWLINE_xXALT (alanine aminotransferase; SGPT), AST (aspartate aminotransferase; SGPT), alkaline phosphatase (ALP) >2.5 upper limit of normal (ULN), unless attributed to GVHD.Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.0 x upper limit of institutional normalXx_NEWLINE_xXCreatinine > 1.5 x institutional upper limit of normal (ULN); total bilirubin > 1.5 x ULN (unless due to Gilbert's disease); and aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3.0 x ULN.Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 2.5 times upper limit of normal (ULN)Xx_NEWLINE_xXELIGIBILITY CRITERIA AT TIME OF TREATMENT: Aspartate aminotransferase (AST) ? 5 x upper limit of normalXx_NEWLINE_xXClinically significant hepatic dysfunction (alanine or aspartate aminotransferase > 7 times the upper limit of normal)Xx_NEWLINE_xXAspartate aminotransferase (AST) ? 3x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 3.0 times upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) =< 2.5 times upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) less than 2.5 times the upper limit of normalXx_NEWLINE_xXAST (aspartate aminotransferase) and ALT (alanine aminotransferase) < 3 times upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 x the institutional upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) > 2.5 times the upper limit of normal at the screening visitXx_NEWLINE_xXAspartate aminotransferase (AST) ? 3 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 2 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to 2.5 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) ?2.5 x the upper limit of normal (ULN), if no liver involvement or ?5 x ULN with liver involvementXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase, (ALT) =< 3.0 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) > 2.5 X upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x institutional upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) less or equal to 2.5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) =< 2 x ULN (upper limit of normal)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2 x upper limit of normalXx_NEWLINE_xXAspartate and alanine aminotransferase (AST or ALT) =< 2 times the upper limit of the reference rangeXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) less than five times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x upper limit of reference rangeXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x upper limits of normalXx_NEWLINE_xXTREATMENT WITH SJCAR19: Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 5 times the upper limit of normal for ageXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) < 5.0 x upper limit of normal (ULN).Xx_NEWLINE_xXHepatic: < 5 x upper limit of normal (ULN) alanine aminotransferase (ALT).Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 5 times upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT) or aspirate aminotransferase (AST) must be < 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) < 5.0 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 3 x upper limit of normal rangeXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than 3 x upper limit of normal (ULN)Xx_NEWLINE_xXHepatic impairment as defined by alanine transaminase (ALT) or aspartate aminotransferase (AST) levels greater than 2 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/ alanine aminotransferase (ALT) =< 2x upper limit of normal (ULN) compatible for surgeryXx_NEWLINE_xXAlanine aminotransferase (ALT) =< 3 x upper limit of normal.Xx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) < 2.5 times upper limit of normal (ULN) if no demonstrable liver metastases or < 5 times ULN in the presence of liver metastases obtained =< 14 days prior to study initiationXx_NEWLINE_xXSTRATUM A: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x upper limit of normal (ULN); for the purposes of eligibility the ULN of ALT and AST is 45 U/LXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 5X upper limit of normal (UNL);Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 X upper limit of normal (ULN) or < 5 X ULN in the presence of liver metastasesXx_NEWLINE_xXAlanine aminotransferase (ALT) =< 1.5 times upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) =< 3 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) =< 3 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) >2.5 times the upper limit of normal (ULN) if no demonstrable liver metastases or >5 times ULN in the presence of liver metastasesXx_NEWLINE_xXSerum alanine aminotransferase (ALT) ?3 × upper limit of normal (ULN) (Grade ?1).Xx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) less than five times the upper limit of normalXx_NEWLINE_xXObtained within 21 days prior to cycle 1, day 1: aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT): =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xX(ALT = alanine aminotransferase, AST = aspartate aminotransferase, ULN = upper limit of normal)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 2.5 x upper limits of normalXx_NEWLINE_xXAspartate aminotransferase/alanine aminotransferase (AST/ALT) =< 1.5 x institutional upper limit of normal (ULN) or if liver metastasis, =< 2.5 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x institutional upper limit of normal (ULN), within 2 weeks of registrationXx_NEWLINE_xXObtained within 28 days prior to registration: aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 3 x the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) ? 2.5 × upper limit of normal (ULN). In the case of known (i.e., radiological or biopsy documented) liver metastasis, serum transaminase levels must be < 5 x ULN.Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than or equal to 3 x the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) > 2.5 times the upper limit of normal at the screening visitXx_NEWLINE_xXAspartate aminotransferase (AST) =< 2.5 upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) < 2.5 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than or equal to 3 x the upper limit of normalXx_NEWLINE_xXAdequate renal and liver function as indicated by: i. Creatinine ? 1.5 x upper-normal limit (ULN) ii. Total bilirubin ? 1.5 x upper-normal limit (ULN) iii. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? 2.5 x ULN iv. Alkaline phosphatase ? 2.5 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x upper limit of normal (ULN) with alkaline phosphatase =< 2.5 x ULN ORXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit normal (ULN), < 5 x in patients with known liver metastasesXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3 x institutional upper limit of normal (ULN), unless felt to be due to disease involvementXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 2.5 X upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 times upper limit of normal (within 16 days before starting therapy)Xx_NEWLINE_xXWithin 4 weeks before enrollment: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 5.0 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 5 x upper limit of normal as per local laboratoryXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 5 x the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN) within 14 days of registrationXx_NEWLINE_xXLiver transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) greater than 3 times the upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 10 upper limit of normal (ULN) (unless elevated ALT/AST is associated with leukemia or lymphoma involvement of the liver, in which case this criterion will be waived and not disqualify a patient)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT) =< 3.5 times the upper limit of normal within 21 days prior to initiation of therapyXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of institutional normal (within 14 days of study registration)Xx_NEWLINE_xXAlanine aminotransferase (ALT), aspartate aminotransferase (AST) < 2.5 x upper limit of institutional normal reference rangeXx_NEWLINE_xXNo more than 14 days prior to registration: Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 X institutional upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/alanine aminotransferase (AST) =< to 2.5 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and Aspartate aminotransferase (AST) ?2.5 times the upper limit of normal (ULN), or ?5 times the ULN for patients with liver metastases;Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN) or =< 5 X ULN for patients with liver metastasesXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 x upper limit of normal (ULN) (=< 5.0 x ULN if liver metastases are involved)Xx_NEWLINE_xXAspartate aminotransferase (aspartate transaminase [AST]) and alanine aminotransferase (alanine transaminase [ALT]) levels ? 2 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) < 2.5 X upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 5 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN) or =< 5 x ULN if related to leukemic involvementXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 times the upper limit of normal; for patients with documented liver metastases, AST/ALT =< 5.0 times the upper limit of normalXx_NEWLINE_xXPatients must have normal hepatic function (bilirubin, aspartate aminotransferase [AST] and alanine aminotransferase [ALT] < 2 times the upper limit of normal)Xx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) within 5 times the upper limit of normal and a total serum bilirubin of less than 3 times the upper limit of normal, both of which define the upper limit of grade 2 treatment related toxicitiesXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 5 times the institutional upper limits of normal.Xx_NEWLINE_xXAspartate aminotransferase (AST) < 5 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 X institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2 x upper limit of normal (ULN) obtained =< 14 days prior to registration\r\n* NOTE: if baseline liver disease, Child Pugh score not exceeding class AXx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST)/bilirubin =< 5 X upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x institutional upper limit of normal, within 2 weeks of registration (except where specified otherwise)Xx_NEWLINE_xXObtained within 14 days prior to enrollment: aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) =< 3 x institutional upper limit of normal (IULN) without liver mets or =< 5 x IULN with liver metastasesXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 X upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN) within 14 days prior to first doseXx_NEWLINE_xX(For both cohorts A and B): Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN) (=< 5 x ULN in patients with liver metastases)Xx_NEWLINE_xXWithin 4 weeks prior to the registration: aspartate aminotransferase (AST) =< 3 X upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x upper limit of normal obtained < 4 weeks prior to starting treatmentXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of institutional normalXx_NEWLINE_xXAspartate aminotransferase (AST) greater than 2.5 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) greater than 2.5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) ? 5 x institution’s upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 2.5 x upper limit of normal (ULN) (or < 5 x ULN if liver metastasis are present)Xx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN) or =< 5 x ULN if documented liver metastases.Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 x upper limit of institutional normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) less or equal to 3 times the upper limit of the institutional normal unless liver involvement by malignancy is demonstratedXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) >= 2.5 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) > 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXHepatic dysfunction characterized by alanine aminotransferase (ALT) >4 × upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 3 x upper limit of institutional normal (ULN), within 14 days of study registration (within 30 days for pulmonary and cardiac assessments)Xx_NEWLINE_xXHepatic: Active hepatitis (alanine aminotransferase [ALT], aspartate aminotransferase [AST], or bilirubin > 2 times the upper limit of normal [ULN]) or evidence of moderate to severe periportal fibrosis by liver biopsyXx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) must be <= 2.5 * the upper limit of the normal range. AST and ALT may be elevated up to 5 times the ULN if their elevation can be reasonably ascribed to the presence of metastatic disease in liver.Xx_NEWLINE_xXObtained =< 14 days prior to registration: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2 times upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 x the institutional upper limit of normal (unless demonstrated Hodgkin lymphoma involvement of the liver); estimated creatinine clearance >= 30 ml/min (Cockcroft-Gault) and/or 24 urine analysis as neededXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT), aspartate aminotransferase (AST) =< 2.5 x upper limit of institutional normal reference rangeXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x upper limit of normalXx_NEWLINE_xXBilirubin =< 1.5 mg/dl (unless Gilbert's syndrome), alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 200 IU/ml for adults; conjugated (direct) bilirubin < 2 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit normal (ULN) or =< 5.0 x ULN if liver tumor is present, within 14 days start of study startXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 times upper limit normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase or aspartate aminotransferase < 3 times the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) > 3 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase < 3 times upper limit of laboratory normalXx_NEWLINE_xXSerum aspartate transaminase (aspartate aminotransferase [AST]) or alanine transaminase (alanine aminotransferase [ALT]) =< 3.0 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional upper limit of normal (ULN); for subjects with liver metastases, AST or ALT =< 5 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) =< 3.0 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN) if no liver involvement or =< 5 x the ULN if documented liver involvementXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 X upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (ALT)/alanine aminotransferase (AST) =< 2.5 times the upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 2.5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than 1.5 X the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 times the upper limit of normal if no liver involvement or =< 5 times the upper limit of normal with liver involvementXx_NEWLINE_xXAspartate aminotransferase (AST) < 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to 2.5 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate transaminase (AST) ? 2.5 × upper limit of the normal reference range (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) without, and =< 5 x ULN with hepatic metastasisXx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) < 5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x upper limit of normalXx_NEWLINE_xXLiver function (total bilirubin <2mg/dL and aspartate aminotransferase and/or alanine aminotransferase <3 × upper limit of normal (ULN) or <5 × ULN if related to leukemic involvement)Xx_NEWLINE_xXLiver function (total bilirubin <2mg/dL and aspartate aminotransferase and/or alanine aminotransferase <3 × upper limit of normal (ULN) or <5 × ULN if related to leukemic involvement)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 5 times the upper limit of normal for ageXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to 2.5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 x institutional upper limit of normal (ULN), except for people with liver involvement by their lymphoma, who may be included if AST/ALT =< 5 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 x institutional upper limit of normal (unless demonstrated Hodgkin lymphoma involvement of the liver); estimated creatinine clearance >= 30 ml/min (Cockcroft-Gault) and/or 24 urine analysis as neededXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) or 5.0 x upper limit of normal (ULN) in the setting of liver metastasesXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) >= 2.5 upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 3 x upper limit normal (ULN), or =< 5 x ULN if documented liver metastases are presentXx_NEWLINE_xXAspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) ? 3 x upper limit of normal (ULN) (? 5.0 x ULN if liver metastases present)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 x the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) above 2.5 upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 2.5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase(AST) and alanine aminotransferase (ALT) < 5 x upper limit of normal and bilirubin < 3 x upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) less or equal to 3 times the upper limit of the institutional normal unless liver involvement by malignancy is demonstratedXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) < 3x upper limit of normalXx_NEWLINE_xXDONOR: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2 x institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN); for subjects with liver metastasis, ALT and AST =< 5 x ULNXx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) must be < 5 x upper limit of normal unless related to diseaseXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to 2.5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 × upper limit of normal (ULN); patient with liver metastases =< 5 × ULNXx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) >= 6 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 x upper limit of institutional normalXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 3 x upper limit of normal rangeXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (alanine transaminase) (ALT) < 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 X upper limit of normalXx_NEWLINE_xXWithin 14 days prior to registration: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 X institutional upper limit of normal OR =< 5 x institutional upper limit of normal in cases of liver metastasesXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 5 X upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.0 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) =< 5 x upper limit of normal (ULN) for ageXx_NEWLINE_xXAspartate aminotransferase (AST) of =< 3 times upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) of =< 3 times upper limit of normalXx_NEWLINE_xXWithin 6 weeks of day 1: Aspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 2.5 x institutional upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT), aspartate aminotransferase (AST) all =< 2.5 x the institutional upper limit of normal (ULN)Xx_NEWLINE_xXARM A COHORT 1: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2 x upper limit of normal (ULN); if liver metastases are present then must be < 5 X the ULNXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum aspartate aminotransferase (AST) < 5 x institutional upper limit of normal (IULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN) (=< 5 x ULN in patients with liver metastases)Xx_NEWLINE_xXAT THE TIME OF INFUSION: Alanine aminotransferase (ALT) ? 5 x normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x institutional upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) must be < 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN); if liver function abnormalities are due to hepatic metastasis, then AST and ALT =< 5 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal for age (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 X the upper limits of normalXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) >= 2.5 x the upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN) (must be within 7 days of MLA)Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) < 2.6 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN) for the laboratoryXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x institutional upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) =< 3 times the institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) =< 3 times the institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than or equal to 3 x upper limit or normal (ULN) (stenting to improve biliary obstruction is permitted)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) < or =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 X upper limit of normalXx_NEWLINE_xXTREATMENT: Aspartate aminotransferase (AST) ? 3 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) < 3 times upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x institutional upper limit of normal (ULN) or =< 5 x ULN for subjects with liver metastasesXx_NEWLINE_xXAspartate aminotransferase (AST) < 2.5 times upper limit of normal, performed within 28 days prior to registrationXx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 2.5 x upper limits of normalXx_NEWLINE_xXAspartate aminotransferase (AST) < 5 times the upper limit of normalXx_NEWLINE_xXSerum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 2 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 X institutional upper limit of normal obtained no more than 28 days prior to the start of neoadjuvant endocrine therapyXx_NEWLINE_xXWithin 2 weeks of enrollment: Alanine aminotransferase (ALT) =< 3 x normal rangeXx_NEWLINE_xXAspartate aminotransferase (AST), and/or alanine aminotransferase (ALT) > 2 x the upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 5 times the institutional upper limits of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to 2.5 times the upper limit of normalXx_NEWLINE_xXPatients must have an alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 times the institutional upper limits of normalXx_NEWLINE_xXIf the research participant is to undergo leukapheresis, he/she must have alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 times the institutional upper limits of normal\r\n* Note: in the event a patient has elevated levels of liver enzymes possibly related to underlying disease, the patient will still be considered eligibleXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? 5 × the upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) >= 3 x the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase/alanine aminotransferase of =< 2.5 × upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN) or < 5 x ULN if related to leukemic involvementXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to 2.5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) /alanine aminotransferase (ALT) =< 3 times upper limit of normal, unless these are thought to be due to AMLXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< twice the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 5 times upper limit of normal (UNL)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) are equal or greater than 2 times the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) < 5 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 3 x upper limit of normal rangeXx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) < 3 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT) =< 3.5 times the upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to 2.5 times the upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 3.5 times the upper limit of normal in the absence of a history of Gilbert's disease (or pattern consistent with Gilbert’s), within 14 days prior to starting therapyXx_NEWLINE_xXSerum alanine aminotransferase (ALT) less than three times the upper limit of normal (Turnstile II)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) obtained within 2 weeks prior to registrationXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x the upper limits of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x the upper limit of normalXx_NEWLINE_xXRECIPIENT: Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 5 times upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) < 3 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 10x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 2.5 times upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limits of normalXx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN) for the laboratoryXx_NEWLINE_xXAlanine aminotransferase (ALT) =< 5 times the upper limit of normal for ageXx_NEWLINE_xXAlanine aminotransferase (ALT), aspartate aminotransferase (AST) < 5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT ) < 2.5 x the upper limits of institutional normal (=< 5 x ULN for patients with liver involvement of leukemia)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 X the upper limit of institutional normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) less than 2 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) less than 2 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 2.5 times upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) < 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAdequate hepatic function as defined by the following criteria:\r\n* Total serum bilirubin =< 1.5 x upper normal limit (ULN), unless due to Gilbert’s syndrome\r\n* Alanine aminotransferase (ALT) =< 2.5 x ULN\r\n* Aspartate aminotransferase (AST) =< 2.5 x ULNXx_NEWLINE_xX< 3 x upper limit of normal (ULN) alanine aminotransferase (ALT)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 2.5 times normalXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 2.5 times upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) =< 5 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x ULN; concomitant elevations in bilirubin and AST/ALT above 1.0 x ULN (upper limit of normal) are not permittedXx_NEWLINE_xXAspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 2 x the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT), aspartate aminotransferase (AST) < 3.0 x the institutional upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT) =< 2.5 x upper limit of normalXx_NEWLINE_xXSerum aspartate aminotransferase (AST) =< 2.5 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 3 X the upper normal limit of institution's normal rangeXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 2.5 times the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 3 x upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin >1.5 times the upper limit of normal (ULN) or alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ? 2.5 X ULN at screeningXx_NEWLINE_xXPatients must have adequate hepatic function as evidenced by total serum bilirubin ? 1.5 x the upper limit of normal (ULN) and a prothrombin time (PT) within 2 seconds of the upper normal limit. Aspartate aminotransferase/alanine aminotransferase (AST/ALT) must be ? 2.5 x ULN.Xx_NEWLINE_xXHave an alanine aminotransferase (ALT)/aspartate aminotransferase (AST) level ?5 times upper limit of normal (ULN)Xx_NEWLINE_xXPatients with alanine aminotransferase (ALT)/aspartate aminotransferase (AST) > 3 times upper limit of normal unless felt to be related the underlying leukemia by the treating physician or hemolysis or Gilbert's diseaseXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) must be < 2 times upper limit of normalXx_NEWLINE_xXAdequate hepatic function with aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 X upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x institutional upper limit of normal for ageXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) 3 times or less than the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) > 5x upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 5 times upper limit of normalXx_NEWLINE_xX< 3 x upper limit of normal (ULN) aspartate aminotransferase (AST)Xx_NEWLINE_xXAspartate aminotransferase (AST) =< 2 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) =< 2 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 times upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x upper limits of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) < 5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2 x the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) =< 5 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) must be =< 3 X normal\r\n* If AST and ALT are > 3 < 5 x upper limit of normal (ULN), patient may be eligible if:\r\n** Liver biopsy performed within 60 days of hematopoietic cell transplantation (HCT) excludes active cirrhosis grade greater than 2/4 and bridging fibrosis\r\n** No clinically evident ascites\r\n** Patient with hepatitis B or C are excluded if AST or ALT > 3 x upper limit (UL)Xx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than 1.5 times the upper limits of normal within 7 days prior to starting treatment in the absence of liver metastasis; in the presence of liver metastasis serum AST and ALT less than or equal to 5.0 times the upper limits of normal within 7 days prior to starting treatmentXx_NEWLINE_xXPatients with organ dysfunction will not be excluded from the study; for patients with evidence of organ dysfunction (creatinine >= 1.5, cardiac ejection fraction =< 50%, total bilirubin >=2 and aspartate aminotransferase [AST]/alanine aminotransferase [ALT] >= 3 times upper limit of normal [ULN]), dose adjustments/omissions will be madeXx_NEWLINE_xXAlanine aminotransferase (ALT) < 2 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 5 x upper limit of normalXx_NEWLINE_xXBilirubin, aspartate aminotransferase (AST)/alanine aminotransferase (ALT), alkaline phosphatase (ALP) =< 2 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN) (AST and ALT =< 6 x ULN for patients on hyperalimentation for whom these abnormalities are felt to be due to the hyperalimentation)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT)? 2.5 × upper limit of normal (ULN) (if liver metastases are present, then?5 x ULN is allowed)Xx_NEWLINE_xXalanine aminotransferase (ALT) and aspartate transaminase (AST) ? 3.0 × upper limit of the normal (ULN),Xx_NEWLINE_xXAlanine aminotransferase level less than or equal to (<=) 2.5* the upper limit of normal (ULN),Xx_NEWLINE_xXAspartate aminotransferase (AST) < 4 times the upper limit of institutional normalXx_NEWLINE_xXAspartate aminotransferase and alanine aminotransferase ? 3 × upper limit of normalXx_NEWLINE_xXPatients with serum aspartate aminotransferase, alanine aminotransferase > 2.5 X the upper limit of normal (ULN) and bilirubin >1.5 ULNXx_NEWLINE_xXAdequate hepatocellular function: aspartate aminotransferase (AST) and alanine transaminase (ALT) ? 3x upper limit of normal within institutional limits; bilirubin ? 1.5 mg/dlXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) within normal range (or =< 3.0 x upper limit of normal [ULN] if liver metastases are present)Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) must be no more than 2.5 times upper limit of normal unless due to disease involvement of the liverXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x upper limit of normal (ULN) or =< 5 x ULN if known hepatic metastasesXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXHPV-ASSOCIATED OROPHARYNX SQUAMOUS CELL CARCINOMA: Aspartate aminotransferase (AST/ SGOT) and alanine aminotransferase (ALT/ SGPT) < 3 x the upper limits of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) < 3 x upper limit of normal (ULN), alanine aminotransferase (ALT) < 3 x ULNXx_NEWLINE_xXAspartate aminotransferase AST, alanine aminotransferase (ALT), and alkaline phosphatase (ALP) ? 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 2.5 x the upper limits of institutional normal (=< 5 x ULN for patients with suspected liver involvement of leukemia)Xx_NEWLINE_xXAspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN) or =< 5 x ULN if documented liver metastasesXx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN) or =< 5 x ULN if documented liver metastases.Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? 2.5 x upper limit normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) level > 3 times the upper limit of normal (x ULN); patients with values > 3 x ULN and < 5 x ULN are eligible if the value is acute and directly related to the infectious process being treatedXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to 3.5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) </= 2.5 x upper limit of normal\r\n(ULN); for subjects with liver metastasis, ALT and AST </= 5 x ULN within 3 weeks prior to initial treatmentXx_NEWLINE_xXAlanine aminotransferase (ALT), and aspartate aminotransferase (AST) > 2.5 x upper limit of normal (ULN).Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 2.5 x the upper limit of normal.Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 X the upper normal limit of institution's normal rangeXx_NEWLINE_xXAlanine aminotransferase (ALT) < 3 times the upper limit of institutional normalXx_NEWLINE_xXWithin 14 days of study registration (30 days for pulmonary and cardiac): aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 x upper limit of institutional normalXx_NEWLINE_xXAspartate aminotransferase (AST) < 2.5 times upper limit of normalXx_NEWLINE_xXObtained within 28 days prior to registration: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal, unless bone or liver metastasis is present (=< 5 x upper limit of normal)Xx_NEWLINE_xXAt cycle 1 day 1 pre-dosing: Alanine aminotransferase level (ALT) >= 2.5 x the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 2.5 X institutional upper limit of normalXx_NEWLINE_xXSubjects with aspartate aminotransferase (AST) or alanine transaminase (ALT) >= 2 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) =< 3 x the upper limit of normal unless considered due to leukemic involvementXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 5 times upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 upper limit of normal (ULN)Xx_NEWLINE_xXAlkaline Phosphatase (ALP), Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) < 2 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) / alanine aminotransferase (ALT) =< 2.5 X upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) ?2.5 × the upper limit of normal (ULN).Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3 × the upper limit of normal (ULN) if no hepatic metastases are present; >5 × ULN if hepatic metastases are present.Xx_NEWLINE_xXSerum aspartate transaminase (alanine aminotransferase [ALT]) and/or aspartate transaminase (aspartate aminotransferase [AST]) values < 3 x the upper limit of normal (ULN) of the local laboratory reference range; patients with elevated bilirubin due to Gilbert’s syndrome may be permitted with principal investigator (PI) approvalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 2.5 x upper limits of normalXx_NEWLINE_xXWithin 14 days prior to step 1 registration: Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 times institutional upper limit of normalXx_NEWLINE_xXPerformed within 14 days prior to study: Alanine aminotransferase (ALT) < 3 times the upper limits of the institutional normalXx_NEWLINE_xXPerformed within 14 days prior to study: Aspartate aminotransferase (AST) < 3 times the upper limits of the institutional normalXx_NEWLINE_xXSubject has a total bilirubin ? 1.5 x upper limit of normal (ULN), albumin ? 2.5 g/dL, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? 2.5 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 x upper limit of normal (ULN); however, in the presence of liver metastases or in patients with refractory leukemias, AST and ALT must be < 5 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than or equal to 3 x the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN) (=< 5 x ULN in case of liver metastases)Xx_NEWLINE_xXHepatic enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) =< 2.5 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) =< 3 times the institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) =< 3 times the institutional upper limit of normalXx_NEWLINE_xXLiver disease: alanine aminotransferase (ALT) or aspartate aminotransferase (AST) greater than 3 times the upper limits of normal, unless determined to be a result of the primary hematologic malignancyXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) < 3 times upper limit of institutional normalXx_NEWLINE_xXCreatinine within normal institutional limits OR creatinine clearance > 60 mL/min/1.73 m^2 for subjects with above normal aspartate aminotransferase (AST) and alanine aminotransferase (ALT) with alkaline phosphatase within < 1.5 times upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limits of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXWithin 14 days of registration: Aspartate aminotransferase (AST) =< 5 x upper limit of normalXx_NEWLINE_xXWithin 14 days of registration: Alanine aminotransferase (ALT) =< 5 x upper limit of normalXx_NEWLINE_xXSerum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 2 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x institutional upper limit of normal (ULN) within 2 weeks before baselineXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< or = 2.5 X institutional upper limit of normal (ULN).Xx_NEWLINE_xXAspartate aminotransferase (AST) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) < 1.5 X upper limit of normal (ULN); patients with Gilbert's disease are exempt from this criteriaXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< upper limit of normal (or < 3.0 x ULN if liver metastases are present)Xx_NEWLINE_xXIn the absence of liver metastases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXTransaminases (aspartate aminotransferase [AST] or alanine aminotransferase [ALT]) =< 3.0 x upper limit of normal (ULN) unless due to leukemia infiltrationXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 times institutional upper normal level (AST and ALT =< 5 times institutional upper normal level, if there is evidence of liver metastasis)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 upper limit of normal (ULN) or =< 5 x ULN if liver metastases are presentXx_NEWLINE_xXAST (aspartate aminotransferase) and ALT (alanine aminotransferase) < 3 times upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 3 x the upper limit of normal, within 14 days prior to registrationXx_NEWLINE_xXSerum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) less or equal to 2.5 times the upper limit of the institutional normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x upper limit of normalXx_NEWLINE_xXSerum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 times the upper limit of normal (ULN) within 14 days prior to admissionXx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal; NOTE: adult values will be used for calculating hepatic toxicity and determining eligibility, as is standard on POB phase I trialsXx_NEWLINE_xXAlanine aminotransferase (ALT), aspartate aminotransferase (AST) =< 4 x institutional upper limits of normal (IULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2 times institutional upper limit of normal (IULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 times upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2 times the institutional upper limit of normalXx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) within 5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) less than 5 times the upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to 3.5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2 x upper limit of normal value (unless elevation is determined by the treating physician to be related to involvement by underlying cancer)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) for patients with liver metastases and =< 2.0 x ULN for patients without liver metastasesXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) of less than 3 X institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) of less than 3 X institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/ alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) < 2.5 times upper limit of normalXx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limits of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limits of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than or equal to 3 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) =< 3.0 times upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) without, and =< 5 x ULN with hepatic metastasisXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x institutional upper limit of normal (=< 5 x institutional upper limit of normal if evidence of liver metastasis)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 1.5 times the upper limits of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 5 times upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) must each be =< 3-times the upper limits of normal (ULN) or =< 10-times normal if due to ATLXx_NEWLINE_xXAspartate aminotransferase (AST) =< 5 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 X upper limit of normal, unless bone metastasis is present in the absence of liver metastasisXx_NEWLINE_xXAspartate aminotransferase (AST) less than 5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) less than 2 times the upper limit of normalXx_NEWLINE_xXNo history of severe prior or ongoing chronic liver disease; aspartate aminotransferase (AST) < 5 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 5 times upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 times upper limit of normal; values above these levels may be accepted, at the discretion of the PI or LAI, if such elevations are thought to be due to liver involvement by malignancy or GVHDXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) >= 3 x laboratory upper normal limitsXx_NEWLINE_xXSerum aspartate aminotransferase and alanine aminotransferase ? 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine transaminase (ALT) and aspartate aminotransferase (AST) =< 5 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) = < 2.5 times upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 x institutional upper limit of normal, unless due to liver metastases (=< 5 x ULN)Xx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? 3.0 x upper limit of normal (ULN);Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN); patients with hepatic metastases: ALT and AST =< 5 x ULNXx_NEWLINE_xXAlanine Aminotransferase (ALT) < 5 times the upper limit of normal (ULN) for age;Xx_NEWLINE_xXSerum/plasma alanine aminotransferase (ALT), and aspartate aminotransferase (AST) ?2 times the upper limit of normal (ULN); ?5 times ULN if there is liver or bone involvement.Xx_NEWLINE_xXAlanine Aminotransferase (ALT) ? 5 times the Upper Limit of Normal (ULN) for ageXx_NEWLINE_xXAspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) ? 2.5 x Upper Limit of Normal (ULN) or ? 3.0 x ULN if liver tumor is present,Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) <=2.0 * upper limit of normal (ULN).Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 times upper limit of normalXx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine transaminase (ALT) ? 2.5 upper limit of the normal range (ULN) (or ? 5 if hepatic metastases are present)Xx_NEWLINE_xXAlanine Aminotransferase (ALT) ? 5 times the upper limit of normal (ULN) for age.Xx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 3 times the upper limit of normalXx_NEWLINE_xXallow alanine aminotransferase (ALT) or aspartate aminotransferase (AST) up to 5x upper limit of normal (ULN) if liver metastases.Xx_NEWLINE_xXSerum aspartate aminotransferase (AST/SGOT) or alanine aminotransferase (ALT/SGPT) > 2.5 × upper limit of normal (ULN)Xx_NEWLINE_xXSubject has total bilirubin (TBL) ? 1.5 x the upper limit of normal (ULN) (except subjects with documented Gilbert's disease), or alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ? 2.5 x the ULN .Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional upper limit of normal (ULN) or =< 5 x ULN if liver involved by lymphomaXx_NEWLINE_xXAspartate aminotransferase (AST) =< 1.5 X upper normal of limit (UNL)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN); if liver metastases are present, =< 5 x ULNXx_NEWLINE_xXHepatic: Aspartate aminotransferase/Alanine aminotransferase <3X upper limit of normal (ULN); Total bilirubin <2X ULN (unless Gilbert's Disease or if liver involvement with lymphoma)Xx_NEWLINE_xXSerum/plasma alkaline phosphatase, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) ?2 times the upper limit of normal (ULN); ? 5 times ULN if there is liver or bone involvement.Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 1.5 x upper limit of normal (ULN) and bilirubin =< ULN for patients without liver metastasesXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 5 x upper limit normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x institutional normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x upper limit of normal (ULN) unless liver metastases documented; in this latter case, AST and ALT < 5 x ULN requiredXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 2.5 x institutional upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 times above the upper limits of the institutional norm; ALT, AST can be < 5 times upper limits of normal if patients have hepatic involvementXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? 3.0 × the upper limit of normal (ULN).Xx_NEWLINE_xXAspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) less than or equal to (<=) 2.5*the upper limit of normal (ULN);Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? 5 × upper limit of normal (ULN) for cases involving liver metastasis and ? 2.5 ×ULN for all other casesXx_NEWLINE_xXHepatic function: serum albumin >3.0 g/dL; aspartate aminotransferase (AST/SGOT) and alanine aminotransferase (ALT/SGPT) <3x the upper limits of normal (ULN); alkaline phosphatase <2x the ULNXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5X institutional upper limit of normalXx_NEWLINE_xXWithin 14 days of study start: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit normal (ULN) or =< 5.0 x ULN if liver tumor is presentXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 times upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) < 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase < 3 times the upper limit of normal (ULN); Note: If elevated liver enzymes are related to disease alanine aminotransferase (ALT) should be < 5 times ULNXx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) < 3x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) > 1.5 x institutional upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) less than three times the upper limit of normalXx_NEWLINE_xXIf liver metastases present, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) must be < 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional upper limit of normal (IULN) or =< 5 x IULN if liver metastases are presentXx_NEWLINE_xXSerum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 5 x the institutional normal upper limitXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (AST) =< 2.5 x upper limits of normal except if due to disease infiltration of the liverXx_NEWLINE_xXAlanine aminotransferase (ALT) =< 2.5 times the UIHC upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) =< 2.5 times the UIHC upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) (Exception: =< 5 x ULN, if elevation is considered related to ASM/MCL)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 3 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT ) =< 2 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST), alkaline phosphatase (ALP), and alanine aminotransferase (ALT) less than or equal to 5 X the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 1.5 X institutional upper limit of normal; subjects with known liver involvement by lymphoma: AST/ALT =< 2 X institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) =< 2.5 x institutional upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) < 2.5 x institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2 x upper limit of normal (ULN) obtained within 4 weeks prior to registrationXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 2.5 x the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) 3 times or less than the upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/serum aspartate aminotransferase (AST) < 2.5 X ULN (the upper limit of normal)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x upper limit of normal (unless the transaminitis is considered to be related to MF)Xx_NEWLINE_xX(ALT = alanine aminotransferase, AST = aspartate aminotransferase, ULN = upper limit of normal)Xx_NEWLINE_xXHepatic: total bilirubin ? 2.5 mg/dL, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) < 5 x upper limit of (ULN) (unless disease related)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXHave adequate hepatic function (bilirubin, aspartate aminotransferase (AST), and alanine aminotransferase (ALT), defined as ? 2 times the upper limit of normal [ULN])Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) within 3 times the upper limits of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) < 3 x the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 5 upper limit of normal or > 250 U/lXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) less than or equal to 3 times institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 5 X upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) =< 2.5 times upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 X upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limits of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 times upper limit of normal (within 16 days before starting therapy)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper normal limit (=< 5 x upper normal limit if documented hepatic involvement with lymphoma)Xx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) < 3 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) =< 3.5 times the upper limit of normal, unless due to chronic GVHDXx_NEWLINE_xXTransaminases (aspartate aminotransferase [AST] or alanine aminotransferase [ALT]) =< 2.0 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT), or aspartate aminotransferase (AST) < 2 x upper limit of normal or < 5 x upper limit of normal if hepatic metastases are presentXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) obtained =< 14 days prior to registrationXx_NEWLINE_xXAspartate aminotransferase/alanine aminotransferase (AST/ALT) > 5 x upper limits of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3.0 x the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) > 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 institutional upper limit of normal (IULN) (=< 5 x IULN if liver metastases are present)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) ?2.0 x the institutional upper limit of normal (ULN), or, in patients with known liver metastases, ?5.0 x the institutional ULN.Xx_NEWLINE_xXAspartate aminotransferase (AST) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 1.5 times the upper limit of normal (ULN)Xx_NEWLINE_xXaspartate aminotransferase (AST) less than or equal to 2.5 × upper limit of normal (ULN)*Xx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 2.5 x the upper limit of the normal range within 21 days prior to study registrationXx_NEWLINE_xXAspartate aminotransferase (AST) < 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN (less than or equal to 5 x upper limit of normal for patients with liver involvement of their cancer)Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 1.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) < 5 x upper limit normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 1.5 x institutional upper limit of normal (IULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 1.5 times upper limit of normal (ULN); (for patients with liver involvement: AST and ALT =< 2.5 ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 2.5 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) within normal range (or =< 3.0 x upper limit of normal [ULN] if liver metastases are present)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal unless the liver is involved with tumor, in that case, ALT/AST must be =< 5 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 1.5 upper limit of normal within 30 days prior to registrationXx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than 1.5 times the upper limits of normal; note: if hepatic function is abnormal, the decision to initiate temozolomide treatment should carefully consider the benefits and risks for the individual patientXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN), or =< 5.0 x ULN if liver metastases are presentXx_NEWLINE_xXAspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) > 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXCreatinine > 1.5 x institutional upper limit of normal (ULN); total bilirubin > 1.5 x ULN (unless due to Gilbert's disease); and aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 2.5 x ULN unless disease related.Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 times upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) < institutional upper normal limitXx_NEWLINE_xXAlanine aminotransferase and aspartate aminotransferase ?2.5 x the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 1.5 times the upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT) < 3.5 times the upper limit of normal within 30 days prior to cycle 1 day 1Xx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) ?2.5 x upper limit of normal (ULN; ?5 x ULN is acceptable if liver metastases are present)Xx_NEWLINE_xXAT THE TIME OF INFUSION: Aspartate aminotransferase (AST) ? 5 x upper limit of normalXx_NEWLINE_xXTotal bilirubin level ?1.5 times institutional upper limit of normal (ULN), alanine aminotransferase or aspartate aminotransferase ?2 x ULNXx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) > 2.5 times the upper limit of normalXx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN); if liver function abnormalities are due to hepatic metastasis, then AST and ALT may be =< 5 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.0 x upper limit of normalXx_NEWLINE_xXalkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 4x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) must be =< 2.5 X the upper limit of normalXx_NEWLINE_xXCreatinine > 1.5 x institutional upper limit of normal (ULN); total bilirubin > 1.5 x ULN (unless due to Gilbert's disease); and aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3.0 x ULN unless disease related.Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 1.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase or aspartate aminotransferase < 3 times upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) >= 2.5 times upper level of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and/ or alanine aminotransferase (ALT) should be =< 2 x upper limit of normal (ULN, defined as per laboratory where blood testing is done)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) must each be =< 2.5 x the upper limits of normalXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 X upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 times the upper limit of normalXx_NEWLINE_xXSubject's total bilirubin is ? 1.5 x upper limit of normal (ULN) (except for subjects with documented Gilbert's disease) or alanine aminotransferase (ALT) or aspartate aminotransferase (AST) is ? 2.5x upper limit of normal (ULN) at Screening.Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) >2.5 x upper limit of normal (ULN) if no demonstrable liver metastases or >5 x ULN in the presence of liver metastasesXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) =< 2.5 x the upper limit of institutional normalXx_NEWLINE_xXHave aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 1.5 X upper limit of normal (ULN)Xx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? 2.5 x institutional upper limit normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 times the institutional upper limit of normal within 4 weeks of enrollmentXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 3 x upper limit of normal (ULN) (< 5 x ULN if subject has liver metastases [mets])Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 x upper limit of normal (ULN) (=< 5.0 x ULN if liver metastases are involved)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 3 x the upper limit of normal within 30 days prior to registrationXx_NEWLINE_xXAlanine aminotransferase and/or aspartate aminotransferase ?2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT) < 3.5 times the upper limit of normal within 7 days of time of consentXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 1.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 times institutional upper limit of normal or =< 5 times institutional upper limit of normal in the presence of liver metastasesXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 1.5 times institutional upper limit of normal or =< 5.0 times institutional upper limit of normal in the presence of liver metastasesXx_NEWLINE_xXAspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) ?3.0 × ULN (Upper limit of normal), unless considered due to leukemic organ involvement.Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 institutional upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional upper limit of normal (ULN)\r\n* NOTE: this applies to patient in the normal and renal dysfunction cohorts (N, R3 and R4); patients with elevated AST and/or ALT may be assigned to liver dysfunction cohortsXx_NEWLINE_xXAlanine transaminase (ALT) and aspartate aminotransferase (AST) =< 5 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 times above the upper limits of the institutional normal (norm)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 times upper limit of normal (within 16 days before starting therapy)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 3 times normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 1.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x upper limit of normal (ULN) (must be within 7 days of MLA)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 6 x upper limits of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 x the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) below the institutional upper limits of normalXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) > 5 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) unless presence of hepatic metastasis in which case AST and ALT =< 5 x ULN are acceptableXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 2.5 X upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal OR two downtrending valuesXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) within 1.5 x normal range (or =< 3.0 x upper limit of normal [ULN] if liver metastases are present)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 5 x upper limit of normal if liver metastases present; otherwise, then =< 2.5 x upper limitXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 6 x upper limits of normalXx_NEWLINE_xXHepatic: Serum total bilirubin ?1.5 x upper limit of normal (ULN) with the exception of <2.9 mg/dL for patients with Gilbert's disease, alanine aminotransferase (ALT/SGPT) and aspartate aminotransferase (AST/SGOT) ?2.5 x ULN.Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) >= 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) < 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 times the institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) =< 1.5 times the upper limit of the normal range (x ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) + alanine aminotransferase (ALT) > 2 upper limits of normal valueXx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) < 3 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normalXx_NEWLINE_xXPatient has poor liver function (> 2.5 times normal of alanine aminotransferase [ALT]/aspartate aminotransferase [AST]) suggestive of cirrhosis or steatohepatitisXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 2.5 x institutional upper limit of normalXx_NEWLINE_xXHave normal serum transaminase values (aspartate aminotransferase [AST] and alanine aminotransferase [ALT])Xx_NEWLINE_xXAlanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xX< 3 x upper limit of normal (ULN) alanine aminotransferase (ALT) andXx_NEWLINE_xXPatients must have the following screening results for hepatic function according to MD Anderson testing standards: total bilirubin < 1.5 times the upper limit of normal; alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST - if available) must be < 2 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate transaminase (AST) less than or equal to 3 times the upper limit of the institution-established normal rangeXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN); in patients with liver dysfunction due to hepatic metastases, AST and ALT are permitted to be =< 5 times the ULNXx_NEWLINE_xXHepatic: < 5 x upper limit of normal (ULN) alanine aminotransferase (ALT)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 X ULN; concomitant elevations in bilirubin and AST/ALT above 1.0 x ULN (upper limit of normal) are not permittedXx_NEWLINE_xXWithin one week of study entry: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal, OR two consecutive downtrending values for patients who have undergone biliary stentingXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 X ULN; concomitant elevations in bilirubin and AST/ALT above 1.0 x ULN (upper limit of normal) are not permittedXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.0 x upper limits of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal OR 5 x upper limit of normal (ULN) for patients status post (s/p) biliary stenting AND decreasing for at least two time points after stentingXx_NEWLINE_xXWithin 14 days prior to registration: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal rangeXx_NEWLINE_xXAspartate aminotransferase (AST) or Alanine aminotransferase (ALT) >3x upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to 2.5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 times upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) < 2.5 X institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) < 2.5 X institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3 x the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) =< 3 x upper limit of institutional normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 x the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) > 2 x upper limit of normalXx_NEWLINE_xXAdequate liver function as evidenced by bilirubin less than 1.5 times the upper limits of normal (ULN) and alkaline phosphatase (AP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) less than 3 x ULN.Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN), unless there are liver metastases in which case AST and ALT =< 5.0 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine transaminase (ALT) < 2 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 3 times the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) =< 2 x the upper limits of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) =< 2.5 times upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2 x upper limit of normalXx_NEWLINE_xXHepatic: < 3 x upper limit of normal (ULN) alanine aminotransferase (ALT)Xx_NEWLINE_xXAspartate aminotransferase/alanine aminotransferase (AST/ALT) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum aspartate transaminase (aspartate aminotransferase [AST]) or alanine transaminase (alanine aminotransferase [ALT]) >= 3.0 x upper limit of normal (ULN)Xx_NEWLINE_xXAdequate hepatic and renal function laboratory values within 14 days prior to registration: Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) =< 3 x the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAsparate aminotransferase (AST) < 2 x the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) < 2 x the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) >= 2.5 times the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? 2 × institutional upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 X upper limit of normal (ULN) (part 1 & 2)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) less than or equal to 5 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN) obtained =< 14 days prior to registrationXx_NEWLINE_xXLiver transaminases (aspartate aminotransferase [AST], alanine aminotransferase [ALT]) less than 10 times the upper limit of normal (unless due to active myositis)Xx_NEWLINE_xXAspartate aminotransferase (AST) =< 3 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 times the upper limit of laboratory normalXx_NEWLINE_xXalanine aminotransferase (ALT), aspartate aminotransferase (AST) < 3.0 x the institutional upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) =< 2 times upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 X institutional upper limit of normalXx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? 2.5 Upper Limit of the Normal range (ULN) (or ? 5 if hepatic metastases are present)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT), aspartate aminotransferase (AST) less than 2.5 times the upper limit of normal without evidence of active infectious hepatitisXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 5 x upper limit of normal (ULN) for ageXx_NEWLINE_xXAspartate aminotransferase and/or alanine transaminase >5 times upper limit of normal.Xx_NEWLINE_xXAlanine aminotransferase (ALT) < 3 x upper limit or normal (ULN)Xx_NEWLINE_xXSerum aspartate aminotransferase and alanine amino-transferase of at least 5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) and/or alkaline phosphatase =< 3 X the upper normal limit of institution's normal rangeXx_NEWLINE_xXAspartate aminotransferase (AST) less 5x normal and alanine aminotransferase (ALT) 5x normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 X normal institutional limitsXx_NEWLINE_xXAST (Aspartate aminotransferase (GOT) and ALT (Alanine aminotransferase (GPT)) < 3.0 × ULN (upper limit of normal) or ? 5 × ULN if subject has documented liver metastasesXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x upper limit of normal (ULN) unless considered to be the result of leukemic involvement by the principal investigator (PI)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN); ALT and AST up to 5 x ULN if liver metastases presentXx_NEWLINE_xXAspartate aminotransferase (AST) < 3 x upper normal limit (UNL)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 X upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) of =< 2.5 x the upper limit of normal (ULN) or =< 5 x ULN if hepatic disease involvement is present as determined by the investigatorXx_NEWLINE_xXTotal bilirubin or alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ? 2.5 times upper limit of normal (ULN) at screening.Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 5.0 times the upper limit of normal unless hepatic dysfunction is related to liver involvement with diseaseXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) within normal range (or =< 3.0 x upper limit of normal [ULN] if liver metastases are present)Xx_NEWLINE_xXAspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) < 3 times the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase or alanine aminotransferase > 3 times the upper limit of normal.Xx_NEWLINE_xXAspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) < 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 times the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2 x upper limit of normalXx_NEWLINE_xXSerum total Bilirubin ? 1.5 x ULN (upper limit of normal) or aspartate aminotransferase (AST) or alanine aminotransferase (ALT) ? 2.5 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) =< 1.5 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) =< 1.5 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) must be =< 2.5 x the upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to 2.5 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST), ?3.0 x the upper limit of normal (ULN); 5 x ULN if known hepatic metastasesXx_NEWLINE_xXAlanine aminotransferase (ALT), aspartate aminotransferase (AST) < 2.5 times the upper limit of normal; in patients with liver metastasis, liver function tests should be < 5 times the upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to 2.5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 times upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) >= 3 x upper limit of normalXx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper normal limit (=< 5 x upper normal limit if documented hepatic involvement with lymphoma)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) within 14 days prior to registrationXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 times upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) > 2.5 times upper normal limit (unless due to disease involvement of liver)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) less or equal to 2.5 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) < 5 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) < 5 x upper limit of normalXx_NEWLINE_xXBilirubin <2 x upper limit of normal (ULN) and aspartate aminotransferase (AST), alanine aminotransferase (ALT) <3 x ULNXx_NEWLINE_xXWithin 14 days prior to first study treatment: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 x upper limit of normal (ULN) (unless the patient has Gilbert’s syndrome, in which case AST and ALT =< 5.0 x ULN is permittedXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal range (ULN)Xx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than 1.5 times the upper limits of normalXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) >5x the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) < 5 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT): =< 2.5 x institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST/SGOT) and alanine aminotransferase (ALT/SGPT) ? 3 x upper limit of normal (ULN) or AST or ALT ? 5 x ULN if liver is involved by disease process as judged by the investigatorXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) within normal limitsXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) >2 × upper limit of normal (ULN),Xx_NEWLINE_xXAspartate aminotransferase (AST) =< 5 x the upper limit of normal; alanine aminotransferase (ALT) =< 5 x the upper limit of normalXx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? 2.5 upper limit of normal (ULN); if liver function abnormalities are due to the underlying malignancy, then AST and ALT must be ? 5 ULN;Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) less than or equal to 3 times the upper limit of the institution-established normal rangeXx_NEWLINE_xXAlanine aminotransferase (ALT) less than 3 X upper limit of normal, aspartate aminotransferase (AST) less than 3 X upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 5 x upper limit of normal, andXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN), with the following exceptions: patients with documented liver metastases: AST and/or ALT =< 5 x ULNXx_NEWLINE_xXSubject has total serum bilirubin ?1.5 times the upper limit of normal (ULN),serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) > 3 times ULN, or albumin ? 3.0 g/dL at Screening.Xx_NEWLINE_xXAspartate aminotransferase (AST) and/or Alanine aminotransferase (ALT) >1.5 x Upper limit of normal (ULN).Xx_NEWLINE_xXAspartate aminotransferase (AST) < 2 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) >= 2.5 times the upper limit of normalXx_NEWLINE_xXPatients are eligible with alanine aminotransferase (ALT) and aspartate aminotransferase (AST) measuring up to 5 x upper limit of normal (ULN) given the presence of liver metastasisXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to 2.5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 times institutional upper normal level (AST and ALT =< 5 times institutional upper normal level, if there is evidence of liver metastasis)Xx_NEWLINE_xXAlanine aminotransferase (ALT) =< 5 times the upper limit of normal for ageXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) =< 5 x the upper limit of normal for ageXx_NEWLINE_xXAspartate aminotransferase (AST) =< 5 x the upper limit of normal for ageXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x the upper limits of normalXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 3.0 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) =< 2.5 × upper limit of normal (ULN); patient with liver metastases =< 5 ×ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? 5 × institutional upper limit of normal (ULN) for cases involving liver metastasis and ? 2.5 ×ULN for all other casesXx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) <2.5 x institutional upper limit normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 x institutional upper limit of normal (IULN) or 3 x IULN with normal alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in patients with Gilbert’s diseaseXx_NEWLINE_xXAdequate hepatic parameters as defined by total bilirubin ? 1.5 x upper limit of normal (ULN) and aspartate aminotransferase (AST/SGOT) and alanine aminotransferase (ALT/SGPT) ? 3 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXTransaminases (aspartate aminotransferase [AST], alanine aminotransferase [ALT]) < 2 times upper limit of normal valuesXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) >= 3 × the upper limit normal (ULN) for the institution (>= 5 × if due to hepatic involvement by tumor)Xx_NEWLINE_xXTotal bilirubin level ?1.5 times institutional upper limit of normal (ULN), alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ?2.0 x ULN except in subjects with known hepatic metastasis, where AST or ALT can be ?5.0 x ULN.Xx_NEWLINE_xXAlanine aminotransferase (ALT) <2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 1.5 x upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) must be =< 2.5 x the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 4.0 x upper limit of normal; this requirement reflects the excretion of CPX-351 by the liverXx_NEWLINE_xXSerum alanine aminotransferase (ALT) =< 3.5 times the upper limit of normal within 14 days prior to randomizationXx_NEWLINE_xXAdequate hepatic function, with bilirubin < 2 times the upper limit of normal (ULN), and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3.5 times ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin (TBL), alanine aminotransferase (ALT) or aspartate aminotransferase (AST) > 2.5 times the upper limit of normalXx_NEWLINE_xXAspartate Aminotransferase (AST) and Alanine transaminase (ALT) < 5.0x the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN) (with exception of patients with Gilbert's syndrome, asymptomatic gallstones, liver involvement with non-Hodgkin lymphoma [NHL] or stable chronic liver disease per investigator assessment)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN); except for patients with hepatic metastases: ALT and AST =< 5 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) within =< 3 x upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) =< 5 x upper limit of normal (ULN) and alanine aminotransferase (ALT) =< 5 x ULNXx_NEWLINE_xXAlanine aminotransferase (ALT) =< 3 times the upper limit of normal for ageXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 X upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to 2.5 times the upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) less than three times the upper limit of normalXx_NEWLINE_xXAdequate hepatic function within 21 days prior to randomization, with bilirubin < 1.5 times the upper limit of normal (ULN), and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 times the ULN.Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) < 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) < 2.5 X institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) < 2.5 X institutional upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 10 × upper limit of normalXx_NEWLINE_xXAspartate aminotransferase or alanine aminotransferase > 2.5 x upper limit of normal.Xx_NEWLINE_xXPatients enrolled with hepatic dysfunction must have laboratory test results for total bilirubin of >1.5x to <=3x the upper limit of normal (ULN) and liver function tests (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) of <8x the ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limits of normalXx_NEWLINE_xXElevated alanine aminotransferase (ALT) or aspartate aminotransferase (AST) > 2.5x the upper limit of normal, except in the presence of known liver metastases in which case levels may be up to 5x the upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 x the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 times the upper limit of normal if no liver involvement or =< 5 times the upper limit of normal with liver involvementXx_NEWLINE_xXSerum total bilirubin less than 2.5 mg/dl, and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values less than or equal to 2.5 times the upper limit of normal; ALT and AST values above these levels may be accepted (up to a maximum of 5 times the upper limit of normal), at the discretion of the principal investigator (PI) or study chairperson, if such elevations are thought to be due to liver involvement by malignancyXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate transaminase (AST) ?2.5*upper limit of normal (ULN), and alkaline phosphatase and total bilirubin within normal limitsXx_NEWLINE_xXAlanine aminotransferase (ALT) AND aspartate aminotransferase (AST) < 3 × upper limit of normal.Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) < 2.5 x institutional upper limit of normal (ULN) and total bilirubin < 1.5 x institutional ULNXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 3 the upper limit of normal (ULN); < 5 ULN if there is liver involvement secondary to the tumorXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 times upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN) (=< 5 x ULN if liver is involved by extramedullary hematopoiesis as judged by the investigator or if related to iron chelator therapy that was started within the prior 60 days)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to 2.5 times the upper limit of normalXx_NEWLINE_xXSerum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to 2.5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 x institutional upper limit of normal (ULN), except for people with liver involvement by their lymphoma, who may be included if AST/ALT =< 5 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN); patient with liver metastases =< 5 x ULNXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 1.5 upper limit normal (ULN), or < 3 x ULN if liver metastases are presentXx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) < 5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/ alanine aminotransferase (ALT) =< 2.5 the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 3.0 x upper limits of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) > 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) greater than 3 x the upper limit of normal (ULN) for the laboratory (lab) being usedXx_NEWLINE_xXAspartate aminotransferase (AST) < 2 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) 5 x upper limit of normal (based on institutional standards)Xx_NEWLINE_xXAspartate aminotransferase (AST) 5 x upper limit of normal (based on institutional standards)Xx_NEWLINE_xXHepatic: total bilirubin less than or equal to (<=) 1.5 times the upper limit of the normal range (ULN); alanine aminotransferase (ALT) and aspartate aminotransferase (AST) <=2.5*ULN.Xx_NEWLINE_xXAspartame aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normalXx_NEWLINE_xXLiver function tests (LFTs) (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) =< 3 X upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) with the following exception: patients with documented liver metastases should have AST and ALT =< 5 x ULN (obtained within 28 days prior to the first study treatment)Xx_NEWLINE_xXModerate to severe liver failure (defined as alanine aminotransferase [ALT] or aspartate aminotransferase [AST] > 3 times upper limit of normal if no liver metastases are present; ALT or AST > 5 times upper limit of normal if liver metastases are present)Xx_NEWLINE_xXPatients with history of severe liver disease, defined as and confirmed by elevated alanine aminotransferase\r\n(ALT) and aspartate aminotransferase (AST) greater than 1.5 times the upper limit of normal.Xx_NEWLINE_xXLaboratory tests (transaminases [alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP)], blood urea nitrogen [BUN] and creatinine not greater than twice normal) and normal electrocardiogram (ECG)Xx_NEWLINE_xXIs known or suspected to have significant hepatic dysfunction, with aspartate aminotransferase (AST) & alanine aminotransferase (ALT) 3 times above upper limit of normal (ULN) per institutional laboratoryXx_NEWLINE_xXObtained =< 30 days prior to registration: Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 3 x the upper limit of normalXx_NEWLINE_xXPatients with severe hepatic impairment as defined as aspartate aminotransferase (AST)/alanine aminotransferase (ALT) greater than three times the upper limit of normal and/or, total bilirubin greater than 3 mg/dL, and/or Child-Pugh score > 9Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) values greater than 5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 2 x institutional upper limit of normal (IULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) =< 1.5 x upper limits of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 5 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum aspartate aminotransferase (AST) =< 1.5 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) > 3 x upper limit of normal (ULN) for the laboratoryXx_NEWLINE_xXLiver enzymes (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) >= 2.5 times the upper limits of normal (ULN) 14 days prior to study enrollmentXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) >= 2.5 upper limit of normal (ULN)Xx_NEWLINE_xXHepatic: < 3 x upper limit of normal (ULN) alanine aminotransferase (ALT)Xx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< 2.5 x the upper normal limitXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 10 times institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 5.0 x upper limit of normal as evidenced by impairment of baseline laboratory valuesXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 X upper limit of normal (ULN)Xx_NEWLINE_xXSignificant hepatic (serum aspartate aminotransferase [AST] and/or alanine aminotransferase [ALT] > 3 time upper limit of normal institutional normal), gastrointestinal, or biliary disorders that could impair absorption, metabolism, or excretion of orally administered medicationsXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) both within 3 x upper limit of normal based on institutional valuesXx_NEWLINE_xXAlanine aminotransferase (ALT) > 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 20 x upper limit of normal (ULN) orXx_NEWLINE_xXObtained =< 30 days prior to randomization: Alanine aminotransferase (ALT) or aspartate transaminase (AST) =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 5.0 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) >3 x the upper limit of normal (ULN) if no hepatic metastases are present; >5 × ULN if hepatic metastases are presentXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) greater than 3 times the upper limit of normalXx_NEWLINE_xXThe screening results for alanine aminotransferase (ALT) must be < 2 times the upper limit of normalXx_NEWLINE_xXThe screening results for aspartate aminotransferase (AST), if available, must be < 2 times the upper limit of normalXx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 X upper limit of normal (ULN) (or =< 5 X ULN if hepatic metastases are present)Xx_NEWLINE_xXAlanine aminotransferase (ALT) greater than 2 x upper limit of normal (> 75 U/L)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) must be < 3.0 times the upper limit of the institutional normal range; test results must be no more than 3 months oldXx_NEWLINE_xXAlanine aminotransferase (ALT) must be < 2 times the upper limit of normal; if available, screening results for aspartate aminotransferase (AST) must be < 2 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) lower than three times the upper\r\nlimit of normalXx_NEWLINE_xXPatient with aspartate aminotransferase (AST) or alanine aminotransferase (ALT) three times the upper limit of normalXx_NEWLINE_xXSerum aspartate aminotransferase (AST) ? 2.0 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) equal to or less than two times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 times the upper normal limitXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) must be < 2 times the upper limit of normal, as evidenced in laboratory values =< 3 months oldXx_NEWLINE_xXTotal bilirubin =< 1.5 x upper limit of normal (ULN) except for Gilbert syndrome or cases clearly not indicative of inadequate organ function, i.e., elevation of indirect (hemolytic) bilirubin in the absence of alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) abnormalityXx_NEWLINE_xXSerum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ? 2.5 times upper limits of normal prior to chemotherapyXx_NEWLINE_xXAspartate aminotransferase (AST) =< 3 x upper limit normalXx_NEWLINE_xXDONOR: Active liver disease (alanine aminotransferase [ALT] or aspartate aminotransferase [AST] levels > 2 times the upper limit of normal [ULN])Xx_NEWLINE_xXSubjects with moderate or severe liver dysfunction at baseline, defined as aspartate aminotransferase, alanine aminotransferase, or alkaline phosphatase levels greater than 5 times the upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) > 1.5 times upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) < 5 x upper limit of normalXx_NEWLINE_xXSerum aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) > 3 times upper limit of institutional normalXx_NEWLINE_xXLiver function: total bilirubin < 2x the upper limit of normal (unless elevated bilirubin is attributed to Gilbert's Syndrome) and alanine aminotransferase (ALT) / aspartate aminotransferase (AST) < 2.5x the upper limit of normal.Xx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate transaminase (AST) =< 3 x upper limit of normal (ULN) obtained =< 30 days prior to registrationXx_NEWLINE_xXSerum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) < 2.5 x the upper limit of normalXx_NEWLINE_xXTransaminases (aspartate aminotransferase [AST], alanine aminotransferase [ALT]) < 2 times upper limit of normal valuesXx_NEWLINE_xXTransaminases (aspartate aminotransferase [AST], alanine aminotransferase [ALT]) < 2 times upper limit of normal valuesXx_NEWLINE_xXAspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) > 3.0 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase < 3 times upper limit of normal valueXx_NEWLINE_xXAlanine aminotransferase < 3 times upper limit of normal valueXx_NEWLINE_xXTransaminases (aspartate aminotransferase [AST], alanine aminotransferase [ALT]) =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXTransaminases (aspartate aminotransferase [AST], alanine aminotransferase [ALT]) < 3 times upper limit of normal valuesXx_NEWLINE_xXDONOR: History of liver disease; a donor with a history of liver disease would be eligible if the serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) are < 2 times upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) > 2.5 × upper limit of normal (CTCAE grade 2)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) =< 1.5 x upper limit of institutional normalXx_NEWLINE_xXAlanine aminotransferase (ALT) =< 1.5 x upper limit of institutional normalXx_NEWLINE_xXAlanine aminotransferase (ALT) =< 2 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase level (ALT) =< 3 x the upper limit of normal (ULN), within 30 days prior to enrollmentXx_NEWLINE_xXAspartate Aminotransferase (AST) and Alanine transaminase (ALT) <10x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) < 5 x upper limit of normal (ULN) (unless due to liver metastasis)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN) (=< 5 x ULN in patients with liver metastases)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) =< 1.8 X upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT) >= 2.0 x upper limit of normal (ULN)Xx_NEWLINE_xXAlanine aminotransferase (ALT)/aspartate aminotransferase (AST) < 2.5 x the upper normal limitXx_NEWLINE_xXAspartate aminotransferase (AST) =< upper limit of institutional normalXx_NEWLINE_xXAlanine aminotransferase (ALT) < 5 X institutional upper limit of normal (ULN)Xx_NEWLINE_xXImpaired liver function defined as values > 3x the upper limit of normal (ULN) for alanine aminotransferase (ALT) or aspartate aminotransferase (AST), alkaline phosphatase (ALP), or total bilirubin.Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) >= 3 x of the upper limits of normalXx_NEWLINE_xXIndividuals with aspartate aminotransferase (AST) and alanine aminotransferase (ALT) > 2.5 x normal upper limit any time during the previous 2 monthsXx_NEWLINE_xXLiver transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) greater than 3 times the upper limit of normalXx_NEWLINE_xXLiver transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) greater than 3 times the upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 2 x upper limit of normalXx_NEWLINE_xXElevated liver function tests (LFTs) (aspartate aminotransferase [AST], alanine aminotransferase [ALT], alkaline phosphatase [ALP] or bilirubin levels greater than 2.5 times the normal limit) from laboratory tests conducted within 30 days prior to surgeryXx_NEWLINE_xXPatients with liver dysfunction: total bilirubin > 2.5 mg/dl; albumin < 2.5 mg/dl; alanine aminotransferase (ALT), aspartate aminotransferase (AST) > 5 times upper limits of normalXx_NEWLINE_xXAspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) greater than 2.5 x upper limits of normalXx_NEWLINE_xXAlanine and aspartate aminotransferase (ALT/AST) =< 2.5 x upper limit of normal (ULN) obtained =< 14 days prior to registrationXx_NEWLINE_xXAspartate aminotransferase (AST) and ALT ?2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 3.0 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)Xx_NEWLINE_xXPatients with depressed liver function, as assessed with a screening liver function test (LFT) yielding serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) greater than the institutional upper limit of normal; or total bilirubin greater than 2 mg/dLXx_NEWLINE_xXLiver transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) greater than 3 times the upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) > 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) within normal institutional limitsXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal, unless attributed to tumor, obtained within 2 weeks prior to registrationXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal unless the liver is involved with tumor, in that case, AST and ALT must be =< 5 x upper limit of normalXx_NEWLINE_xXHave normal serum transaminase values (aspartate aminotransferase [AST] and alanine aminotransferase [ALT])Xx_NEWLINE_xXGreater than 3 x the upper limit of normal (ULN) for alanine aminotransferase (ALT), aspartate aminotransferase (AST)Xx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal unless the liver is involved with tumor, in that case, ALT/AST must be =< 5 x upper limit of normalXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) within normal limitsXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 X institutional upper limit of normalXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3 x upper limit of normal (ULN)Xx_NEWLINE_xXImpaired liver function defined as values > 3x the upper limit of normal (ULN) for alanine aminotransferase (ALT) or aspartate aminotransferase (AST), alkaline phosphatase (ALP), or total bilirubin.Xx_NEWLINE_xXHepatic: total bilirubin less than or equal to (<=) 1.5*the upper limit of the normal range (ULN); alanine aminotransferase (ALT) and aspartate aminotransferase (AST) <=2.5*ULN.Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) at screening > 3x upper limit of normal (ULN)Xx_NEWLINE_xXAspartate aminotransferase or alanine aminotransferase at screening >3.0 x upper limit of normal (ULN) unless considered due to leukemic organ involvementXx_NEWLINE_xXSerum/plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ?2 times the upper limit of normal (ULN); ?5 times ULN if there is liver or bone involvement.Xx_NEWLINE_xXAlanine aminotransferase (ALT) =< 1.5 times upper limit of normalXx_NEWLINE_xX