Must be obtained within 14 days prior to registration for protocol therapy: Creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated a creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 30 mL/min for subject with creatinine levels > 1.5 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXWithin 14 days of treatment initiation: Serum creatinine =< 1.5 x ULN OR measured or calculated creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXWithin 21 days of treatment initiation:\r\nSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl)Xx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 50 mL/min for subject with creatinine levels > 1.5 X institutional ULN (within 14 days of treatment initiation)Xx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subjects with creatinine levels > 1.5 x institutional ULN obtained within 14 days prior to registrationXx_NEWLINE_xXWithin 14 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (up to 14 days before treatment initiation)Xx_NEWLINE_xXWithin 14 days of treatment initiation:\r\nSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXWithin 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< serum creatinine =< 1.5 x upper limit of normal (ULN) or creatinine clearance (CrCl) >= 40 mL/min (if using the Cockcroft-Gault formula), performed within 10 days of treatment initiation\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 x institutional upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN, performed within 14 days of treatment initiation\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXCOHORT 1: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or corrected creatinine [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 14 days of treatment initiationXx_NEWLINE_xXCOHORT 2: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (GFR can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 14 days of treatment initiationXx_NEWLINE_xXSAFETY RUN-IN: Within 10 days of registration: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXRANDOMIZED PHASE II CLINICAL TRIAL: Within 10 days of registration: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (GFR can also be used in place of CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X ULN OR creatinine clearance (measured or calculated) >= 60 mL/min for participants with creatinine levels > 1.5 X ULN (glomerular filtration rate [GFR] can be used in place of creatinine or creatinine clearance), performed within 14 days of treatment initiationXx_NEWLINE_xXMeasured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXWithin 10 (except as noted) days of planned treatment initiation: Serum creatinine =< 1.5 x the upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for patients with creatinine levels > 1.5 x institutional ULN (calculated per institutional standard). (glomerular filtration rate can be used in place of creatinine or creatinine clearance)Xx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance >= 60 mL/min for patient with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])\r\n* Creatinine clearance should be calculated per institutional standard.Xx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 10 days of treatment initiation\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXWithin 14 days of treatment registration: Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (creatinine clearance should be calculated per institutional standard), performed within 14 days of treatment initiationXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 30 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 14 days of treatment initiation\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 14 days of D1 of treatment under LCCC1522Xx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (performed within 28 days of treatment initiation)Xx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 30 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X institutional upper limit of normal (ULN) OR measured or calculated creatinine clearance should be calculated per institutional standard (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 28 days of study registrationXx_NEWLINE_xXPerformed within 10 business days of treatment initiation with the exception of beta- HCG (72 hours), if applicable: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXAt time of registration and within 4 weeks prior to initiating on-protocol treatment: Creatinine =< 1.5 x upper limit of normal (ULN), OR measured or calculated creatinine clearance (glomerular filtration rate (GFR) can also be used in place of creatinine or CrCl) >= 60 mL/min/1.73m^2 for participants with creatinine levels > 1 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard. For participants with a baseline calculated creatinine clearance below normal institutional laboratory values, a measured baseline creatinine clearance should be determined. Individuals with higher values felt to be consistent with inborn errors of metabolism will be considered on a case-by-case basis.Xx_NEWLINE_xXWithin 10 days prior to the start of study treatment: Creatinine =<1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCl) >= 30 mL/min for participant with creatinine levels > 1.5 x institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl)Xx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance\r\n(glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 28 days of treatment initiationXx_NEWLINE_xXPerformed within 10 days of treatment initiation: Serum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) ? 40 mL/min for subject with creatinine levels > 2.0 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN, should be performed within 10 days of treatment initiationXx_NEWLINE_xXSerum creatinine =< 1.5 x institutional upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCL) >= 50 mL/min (creatinine clearance should be calculated per institutional standard); glomerular filtration rate (GFR) can also be used in place of creatinine of CrClXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR Measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]), performed within 10 days of treatmentXx_NEWLINE_xXSerum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance ? 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) within 21 days of treatment initiation\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or corrected creatinine [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 21 days of treatment initiationXx_NEWLINE_xXPerformed within 10 days of treatment initiation: serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXShould be performed within 30 days of treatment initiation: Serum creatinine ? 2.0 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) ? 60 mL/min for subject with creatinine levels ? 1.5 X institutional ULNXx_NEWLINE_xXWithin 28 days of cycle 1 day 1: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (performed within 10 days of treatment initiation) (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXWithin 5 days prior to the start of study treatment: Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional upper limit of normal (ULN). Creatinine clearance should be calculated per institutional standard.Xx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 14 days of treatment initiationXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance\r\n(glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 28 days of treatment initiationXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) for age; if the serum creatinine is above these values, the calculated creatinine clearance or radioisotope glomerular filtration rate (GFR) must be >= 70 mL/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXCreatinine OR calculated creatinine clearance =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN. Creatinine clearance should be calculated per institutional standard.Xx_NEWLINE_xXTo be performed within 14 days of treatment initiation: serum creatinine ? 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) ? 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXSerum creatinine ? 2.0 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) ? 60 mL/min for subject with creatinine levels > 2.0 X institutional ULN within 14 days of treatment initiation\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXWithin 10 days of treatment initiation: Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN. Note: Creatinine clearance should be calculated per institutional standard.Xx_NEWLINE_xXWithin 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXWithin 14 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =<1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]), performed within 10 days of treatment initiation\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXPerformed within 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance glomerular filtration rate (GFR) can also be used in place of creatinine or creatinine clearance (CrCl) =< 1.5 x upper limit of normal (ULN) OR =< 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN.\r\n* Creatinine clearance should be calculated per institutional standard.Xx_NEWLINE_xXWithin 7 days of registration: Creatine =< 1.7 x upper limit of normal (ULN) OR measure or calculateda creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 70.0 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXObtained =< 14 days prior to registration: Creatinine =< 1.5 X upper limit of normal (ULN)\r\n* NOTE: measured or calculated (per institutional standard) creatinine clearance is acceptable >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXWithin 10 days prior to on-study date: Serum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) ? 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine < 2.0 mg/dl OR measured or calculated creatinine clearance (GFR can also be used in place of creatinine or CrCl) ? 50 ml/mm within 10 days prior to “on study” status\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXCreatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXWithin 28 days prior to enrollment: Serum creatinine OR measured calculated creatinine clearance (glomerular filtration rate [GFR] may also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels >= 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine adults: =< 1.5 X upper limit of normal (ULN) children age >= 14: =< 1.5 mg/dL OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) OR >= 30 mL for subject with creatinine levels > 1.5 X institutional ULN (CrCl should be calculated per institutional standard)Xx_NEWLINE_xXWithin 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXWithin 10 days of treatment initiation: Serum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) ? 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) ? 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance >= 50 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) (performed within 10 days of treatment initiation)Xx_NEWLINE_xXPerformed within 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (creatinine clearance should be calculated per institutional standard) (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN, performed within 10 days of treatment initiationXx_NEWLINE_xXPerformed within 7 days of treatment initiation: Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXPerformed within 14 days of treatment initiation: Serum creatinine =< 1.5 upper limit of normal (ULN) OR measured calculated creatinine clearance (glomerular filtration rate [GFR] may also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels >= 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 2.0 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subjectXx_NEWLINE_xXSerum creatinine OR measured or calculated a creatinine clearance (GFR can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN, performed within 14 days of treatment initiationXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN, performed within 10 days of treatment initiationXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) OR serum creatinine clearance (CL) > 40 mL/min by the Cockcroft-Gault formula or by 24-hour urine collection for determination of creatinine clearanceXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]); serum creatinine =< 1.5 x upper limit of normal (ULN) or creatinine clearance >= 40 mL/min (if using Cockcroft-Gault formula), performed within 14 days of protocol registrationXx_NEWLINE_xXPerformed within 10 days of treatment initiation: Serum creatinine or measured or calculated creatine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrcL]) =< 2.0 x upper limit of normal (ULN) or >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN. Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine >= 1.5 x upper limit of normal (ULN) OR calculated creatinine clearance =< 30 mL/min for patients with creatinine levels > 1.5 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXCreatinine =< 1.5 x ULN OR measured or calculated creatinine clearance >= 50 mL/min for subject with creatinine levels > 1.5 x institutional ULN; (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])Xx_NEWLINE_xXWithin 28 days prior to registration for protocol therapy: Creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXPerformed within 10 days of treatment initiation: Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])\r\n* Creatinine clearance should be calculated per Cockcroft-Gault equationXx_NEWLINE_xXDetermined within 3 weeks of treatment initiation: Serum creatinine =< 1.5 x ULN or a measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (Note: creatinine clearance need not be determined if the baseline serum creatinine is within normal limits; glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN; creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 14 days of treatment initiation; creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR calculated creatinine clearance (CrCL) per institutional standard (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXWithin 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXWithin 14 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) =< 1.5 X institutional upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 14 days of registrationXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 40 mL/min creatinine clearanceXx_NEWLINE_xXPerformed within 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) Or measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance\r\n(glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (performed within 28 days of registration)Xx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) or >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN performed within 10 days of treatment initiationXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) or measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (within 10-15 days of treatment initiation)Xx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 50 mL/min for patient with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 16 days of treatment initiationXx_NEWLINE_xXCreatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance) =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN; Note: creatinine clearance should be calculated per institutional standard performed within 7 days of treatment initiationXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN, during screening and on cycle 1, day 1Xx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 14 days of treatment initiationXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (should be calculated per institutional standard) (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels =< 1.5 X institutional ULN (performed within 10 days of treatment initiation)Xx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXWithin 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN; creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine: =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for participant with creatinine levels > 1.5 X institutional ULN; glomerular filtration rate (GFR) can also be used in place of creatinine or creatinine clearance (CrCl)Xx_NEWLINE_xXCompleted within 10 days of SBRT treatment initiation: Measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN OR creatinine clearance (if measured or calculated per institutional standard) >= 60 mL/min if creatinine levels > 1.5 x ULN\r\n* Glomerular filtration rate (GFR) can also be used in place of creatinine or creatinine clearance (CrCl)Xx_NEWLINE_xXMeasured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subjects with creatinine levels > 1.5 x ULN within 14 days of treatment initiationXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 14 days prior to registrationXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or calculated creatinine clearance [CrCl]) creatinine clearance >= 60 mL/min (for subject with creatinine levels > 1.5 X institutional ULN) determined by 24-hour collection or estimated by Cockcroft-Gault formulaXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min/1.73 m^2 for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]), performed within 10 days of treatment initiationXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl)Xx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXMeasured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 30mL/min for subject with creatinine levels > 1.5 X institutional upper limit of normal (ULN)Xx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) or measured or calculated creatinine clearance (CrCl) (Glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 40 mL/min CrCl using the Cockroft-Gault formulaXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (IULN); creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine >= ULN and/or calculated or measured creatinine clearance < 75% lower limit of normal (LLN)Xx_NEWLINE_xXPerformed 28 days prior to study registration up to the first dose of study drug: serum creatinine or measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) or >= 40 mL/min CrCl using the Cockroft-Gault formulaXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance\r\n(glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]), performed within 10 days of treatment initiationXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) or measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN; glomerular filtration rate (GFR) can also be used in place of creatinine or creatinine clearance (CrCl) (within 28 days of treatment initiation)\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXCreatinine =< 2.0 x upper limit normal (ULN) or measured creatinine clearance (CrCl) of >= 50ml/m^2/1.73 m^2Xx_NEWLINE_xXPerformed within 14 days (+3 working days) of treatment initiation: Serum creatinine OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN\r\n* Note: creatinine clearance should be estimated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (institutional upper limit of normal, IULN) OR measured or calculated creatinine clearance (GFR can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXPerformed within 14 days of treatment initiation: Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) OR >= 50 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance rate [CrCl]) >= 35 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 ml/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])Xx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance rate [CrCl])\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXPerformed within 28 days prior to study registration up to the first dose of study drug: Serum creatinine or measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or calculated creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) or >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (creatinine clearance should be calculated per institutional standard)Xx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated* creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN; (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 50 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine or measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) or >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (creatinine clearance should be calculated per institutional standard), performed within 10 days of treatment initiationXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXPerformed within 10 days of treatment initiation; serum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) ? 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN \r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated* creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional upper limit of normal (ULN) (glomerular filtration rate [GR] can also be used in place of creatinine or creatinine clearance [CrCl])\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine >1.5 x ULN and/or measured or calculated creatinine clearance <75% LLNXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) =< 1.5 X upper limit of normal (ULN) OR >= 50 mL/min for subject with creatinine levels > 1.5 X institutional ULN; creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Note: creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR calculated creatinine clearance >= 60 mL/min for patients with creatinine levels > 1.5 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) ? 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine ? 1.5 x Upper Limit of Normal (ULN) OR o glomerular filtration rate (GFR) ?30mL/min if serum creatinine > 1.5 x ULN, creatinine clearance may be calculated using the institutional/laboratory standard methodXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearnace [CrCl]) >= 40 mL/min for subject with creatinine levels > 2.0 X institutional ULN, should be performed within 10 days of treatment initiationXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) ? 60 ml/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 40 mL/min for subject with creatinine levels > 1.5 X institutional ULN; creatinine clearance should be calculated by Cockcroft-GaultXx_NEWLINE_xXSerum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCl) ? 50 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 7 days of treatment initiation\r\n* Glomerular filtration rate (GFR) can also be used in place of creatinine or CrClXx_NEWLINE_xXAll screening labs should be performed within 14 days (+3 working days) of treatment initiation: serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN;Xx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (GFR can also be used in place of creatinine or creatinine clearance [CrCl]) >= 30 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 28 days of treatment initiationXx_NEWLINE_xXWithin 10 days of treatment initiation: Serum creatinine within upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > institutional ULNXx_NEWLINE_xXCreatinine or measured/calculated creatinine clearance (as calculated by institutional standard) =< 1.5 X institutional upper limit of normal (ULN) OR >= 60 mL/min for subjects with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance must be >= 60 mL/min for subjects with creatinine levels > 1.5 X ULN using the Cockcroft-Gault formula (glomerular filtration rate [GFR] >= 60 mL/min [1.0 mL/s/m^2] can also be used in place of creatinine or creatinine clearance [CrCl]) obtained =< 28 days prior to registrationXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance >= 60 mL/min for patient with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])Xx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN, performed within 10 days of treatment initiationXx_NEWLINE_xXSerum creatinine <= 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X ULN or measured or calculated creatinine clearance (CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl); creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 x institutional upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance rate [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 50 mL/min for participant with creatinine levels > 1.5 x institutional ULN, specimens must be collected within 10 days prior to the start of study treatment\r\n* Creatinine clearance (CrCl) should be calculated per institutional standardXx_NEWLINE_xXWithin 30 days prior to treatment initiation: Serum creatinine =< 1.5 X institutional upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 30 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXMeasured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or calculated or directly measured creatinine clearance (CrCl) >= 50% LLN (lower limit of normal)Xx_NEWLINE_xXSerum creatinine < 2.5 X institutional ULN OR measured or calculated* creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 30 mL/min for subject with creatinine levels > 2.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXMeasured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 50 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXRenal function: Creatinine ?1.5x ULN OR measured or calculated creatinine clearance (Glomerular filtration rate [GFR]) can also be used in place of creatinine or CrCl) > 60 mL/min for subjects with creatinine levels > 1.5x institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated* creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrC])\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) or measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or calculated creatinine clearance [CrCl])Xx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN OR creatinine clearance (if measured or calculated per institutional standard; glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min if creatinine levels > 1.5 x ULN (within 14 days prior to day 1 of protocol therapy)Xx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (performed within 10 days of treatment initiation)\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN, performed within 10 days of treatment initiationXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXMeasured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for participant with creatinine levels > 1.5 x institutional ULN (within 14 days of treatment initiation)Xx_NEWLINE_xXMeasured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN; creatinine clearance should be calculated per institutional standard, should be performed within 28 days of treatment initiation, unless otherwise indicatedXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]); creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional upper limit of normal (ULN)Xx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) (creatinine clearance will be calculated per institutional standard) =< 1.5 × upper limit of normal (ULN) OR >= 60 mL/min GFR or CrCl for subjects with creatinine levels > 1.5 × institutional ULN, performed within 28 days of treatment initiationXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN\r\n* Glomerular filtration rate (GFR) can also be used in place of creatinine or creatinine clearance (CrCl)\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN; creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 50 mL/min for subject with creatinine levels > 1.5 X institutional ULN; creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN; creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 14 days prior to registrationXx_NEWLINE_xXWithin 14 days of treatment initiation: Serum creatinine =< 1.5 X institutional upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXPerformed within 28 days of radiation therapy: Serum creatinine =< 1.8 x upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 50 mL/min for subject with creatinine levels > 1.8 x institutional ULN; (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])Xx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]); creatinine clearance should be calculated per institutional standard, performed within 28 days of treatment initiationXx_NEWLINE_xXSerum creatinine =< 1.5 upper limit of normal (ULN) OR measured calculated creatinine clearance >= 60 mL/min for subject with creatinine levels >= 1.5 X institutional ULN (glomerular filtration rate [GFR] may also be used in place of creatinine or creatinine clearance [CrCl])Xx_NEWLINE_xXSerum creatinine =< 2.5 x ULN OR measured or calculated* creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 30 mL/min for subject with creatinine levels > 2.5 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard (labs should be performed within 14 days of treatment initiation)Xx_NEWLINE_xXAt least 4 weeks (28 days) prior to registration: Serum creatinine =< 1.5 x ULN or calculated or directly measured creatinine clearance (CrCl) >= 50% LLN (lower limit of normal)Xx_NEWLINE_xXSubjects must have a serum creatinine level that is ? 1.5 × institutional upper limit of normal (ULN) according to age. If serum creatinine level is > 1.5 × ULN, the subject must have a calculated creatinine clearance or radioisotope glomerular filtration rate (GFR) ? 70 mL/min/1.73 m2.Xx_NEWLINE_xXSerum creatinine =< 1.5 × the institutional ULN; if creatinine is above the ULN, the patient's measured or calculated creatinine clearance (CrCl) must be >= 50 mL/minXx_NEWLINE_xXSerum creatinine =< upper limit of normal (ULN) for age; if serum creatinine above these values, the calculated creatinine clearance or radioisotope glomerular filtration rate (GFR) must be >= 60 ml/min/1.73 m^2Xx_NEWLINE_xXCreatinine less than or equal to 1.5 x institutional upper limit of normal (ULN) or measured or calculated creatinine clearance greater than or equal to 50 mL/min for subject with creatinine levels greater than 1.5 x institutional ULN; (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) (creatinine clearance should be calculated per institutional standard)Xx_NEWLINE_xXSerum creatinine OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x institutional upper limit of normal (ULN) OR (measured via 24-hour urine collection) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) or measured or calculated creatinine clearance\r\n(glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine > 1.5 x ULN and/or measured or calculated creatinine clearance < 75% LLN (lower limit of normal) Bone marrow function:Xx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN within 7 days of treatment initiation; (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]); creatinine clearance should be calculated per institutional standardXx_NEWLINE_xXPerformed within 10 days of treatment initiation: Serum creatinine =< 1.5 x ULN OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine clearance (CrCl) levels > 1.5 x institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl)Xx_NEWLINE_xXMeasured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXCreatinine OR Measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXPerformed within 10 days of treatment initiation: Measured or calculated creatinine clearance >= 60 mL/min for patient with creatinine levels > 1.5 x institutional ULN\r\n* Creatinine clearance (CrCl) should be calculated per institutional standard; glomerular filtration rate (GFR) can also be used in place of creatinine or CrClXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate (GFR) can also be used in place of creatinine or creatinine clearance [CrCl]) =< 2.0 x upper limit of normal (ULN) OR >= 40 mL/min for subject with creatinine levels > 2.0 x institutional ULN (performed within 10 days of treatment initiation)Xx_NEWLINE_xXSerum creatinine =< 1.5 x institutional upper limit of normal (ULN) for age; if the serum creatinine is above these values, the calculated creatinine clearance or radioisotope glomerular filtration rate (GFR) must be >= 60 mL/min/1.73m^2Xx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance within normal institutional limits; glomerular filtration rate (GFR) can also be used in place of creatinine or creatinine clearance (CrCl) within normal institutional limits as adjusted for age and sexXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 10 days of treatment initiationXx_NEWLINE_xXSerum creatinine: =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for participant with creatinine levels > 1.5 X institutional ULN (using Cockcroft-Gault equation), glomerular filtration rate (GFR) can also be used in place of creatinine or creatinine clearance (CrCl)Xx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min using the Cockcroft-Gault formula for subject with creatinine levels > 1.5 x institutional upper limits of normal (ULN), obtained within 14 days prior to C11-AMT PET scanXx_NEWLINE_xXSerum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, obtained =< 30 days prior to registrationXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCL]); creatinine clearance should be calculated per institutional standard, performed within 10 days of treatment initiationXx_NEWLINE_xXSerum creatinine =< 4.0 x ULN or calculated or directly measured creatinine clearance (CrCl) >= 50% of LLN (lower limit of normal)Xx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULNXx_NEWLINE_xXSerum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXMeasured or calculated creatinine clearance (CrCl; GFR can also be used in place of CrCl) >= 30 mL/minXx_NEWLINE_xX