History of active primary immunodeficiencyXx_NEWLINE_xXPatients with known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) might be enrolled if the viral load by PCR is undetectable with/without active treatment and absolute lymphocyte count >= 350/ulXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) related illnessXx_NEWLINE_xXPatients known to be human immunodeficiency virus (HIV) positive with a baseline cluster of differentiation (CD)4 count of < 250 cells/mm^3 or have a history of acquired immune deficiency syndrome (AIDS) indicator conditionsXx_NEWLINE_xXPatients must not have any history of primary immunodeficiencyXx_NEWLINE_xXPatients known to be human immunodeficiency virus (HIV) positive with one or more of the following:\r\n* Baseline cluster of differentiation (CD)4 count of < 250 cells/mm^3\r\n* History of acquired immune deficiency syndrome (AIDS) indicator conditions\r\n* Anti-retroviral therapy with any potent CYP3A4 inhibitorXx_NEWLINE_xXPatients with an immunodeficiency that existed prior to diagnosis, such as primary immunodeficiency syndromes, organ transplant recipients and children on current systemic immunosuppressive agents are not eligibleXx_NEWLINE_xXPatients with an immunodeficiency that existed prior to diagnosis such as primary immunodeficiency syndromes or organ transplant recipients are not eligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) related illnessXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS).Xx_NEWLINE_xX14. History of primary immunodeficiency;Xx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness, or known active or chronic hepatitis B or C infectionXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS); HIV-positive participants are ineligibleXx_NEWLINE_xXHas diagnosis of immunodeficiencyXx_NEWLINE_xXKnown history of positive testing for human immunodeficiency virus or history of acquired immune deficiency syndrome.Xx_NEWLINE_xXHas a diagnosis of immunodeficiencyXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) positivity or acquired immunodeficiency syndrome (AIDS)-related illnessXx_NEWLINE_xXPrior diagnosis of inherited or acquired immunodeficiencyXx_NEWLINE_xXActive or known history (standard pre-ASCT assessments) of:\r\n* Hepatitis B or C infection\r\n* Human immunodeficiency virus (HIV)\r\n* Acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown history of human immunodeficiency virus (HIV) or acquired immunodeficiency-related (AIDS) illnesses.Xx_NEWLINE_xXPatients should be excluded if they have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS); appropriate studies will be undertaken in participants receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHas a diagnosis of immunodeficiencyXx_NEWLINE_xXSubject has known primary immunodeficiency or active tuberculosis or tests positive for acquired human immunodeficiency virus;Xx_NEWLINE_xXKnown immunodeficiency disorders, either primary or acquiredXx_NEWLINE_xXKnown human immunodeficiency virus or acquired immunodeficiency syndrome related illness.Xx_NEWLINE_xXAny patient with a history of genetic or acquired immune suppression disease such as human immunodeficiency virus (HIV) is excluded; subjects on immune suppressive therapy for organ transplant are also excludedXx_NEWLINE_xXParticipants with a known history of testing positive for human immunodeficiency virus (HIV), or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHas a diagnosis of immunodeficiencyXx_NEWLINE_xXKnown history of positive test for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS). NOTE: Testing for HIV must be performed at sites where mandated locally.Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown history of positive test for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown history of positive testing for human immunodeficiency virus or history of acquired immune deficiency syndrome.Xx_NEWLINE_xXKnown positive test for hepatitis B, hepatitis C, human immunodeficiency virus (HIV), or acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown positive history or positive test for human immunodeficiency virus or acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXActive uncontrolled infection, including known history of human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) or hepatitis B or CXx_NEWLINE_xXIndividuals who are known to have acquired immunodeficiency syndrome (AIDS) (cluster of differentiation [CD] 4 < 200 or an AIDS-defining illness) or are known to be human immunodeficiency virus (HIV) positive and not on highly active antiretroviral therapy (HAART) are ineligibleXx_NEWLINE_xXHIV uninfected and infected women (without acquired immunodeficiency syndrome [AIDS] defining illness)Xx_NEWLINE_xXKnown infection with human immunodeficiency virus (HIV) or acquired immune deficiency syndrome (AIDS) (testing not required).Xx_NEWLINE_xXAcquired immune deficiency syndrome (AIDS) due to the potential for increased complications from treatment; note, however, that HIV testing is not requiredXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness that is not well controlled.Xx_NEWLINE_xXKnown history of human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXPrimary immunodeficiencyXx_NEWLINE_xXKnown history of primary immunodeficiencyXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness (HIV-positive subjects on combination anti-retroviral therapy are ineligibleXx_NEWLINE_xXPatients undergoing allogeneic HSCT for correction of a primary immunodeficiency disorder (e.g. severe combined immunodeficiency [SCID])Xx_NEWLINE_xXHuman immunodeficiency virus (HIV) positive or other acquired immunodeficiency that, as determined by the PI, interferes with the assessment of PID severity and/or the attribution of clinical manifestations of immunodeficiency to a PIDXx_NEWLINE_xXAcquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocol; protocol-specific requirements may also exclude immune-compromised patientsXx_NEWLINE_xXKnown to have lymphoma related to HIV or acquired immune deficiency syndrome (AIDS)Xx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease and acquired immunodeficiency syndrome [AIDS])Xx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXEXCLUSION - PROCUREMENT: Known primary immune deficiency or human immunodeficiency virus (HIV) positivityXx_NEWLINE_xXPatients with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) and those severely immunocompromised will be excluded; however, no patients will be tested for HIVXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXAcquired immune defects such as human immunodeficiency virus (HIV) or innate immunodeficiencyXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease and acquired immune deficiency syndrome [AIDS])Xx_NEWLINE_xXKnown positive test for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS).Xx_NEWLINE_xXAUTOLOGOUS APHERESIS: Known primary immunodeficiencyXx_NEWLINE_xXTREATMENT WITH SJCAR19: Known primary immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus or known acquired immunodeficiency syndromeXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease).Xx_NEWLINE_xXHuman immunodeficiency virus (HIV) seropositivity or other congenital or acquired immune deficiency state, which would increase the risk of opportunistic infections and other complications during chemotherapy-induced lymphodepletion; if there is a positive result in the infectious disease testing that was not previously known, the patient will be referred to their primary physician and/or infectious disease specialistXx_NEWLINE_xXHistory of primary immunodeficiency.Xx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS).Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXPrimary immunodeficiency.Xx_NEWLINE_xXHistory of active primary immunodeficiency.Xx_NEWLINE_xXHas a history of primary immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease and acquired immunodeficiency syndrome [AIDS])Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndromeXx_NEWLINE_xXKnown history of positive testing for human immunodeficiency virus or history of acquired immune deficiency syndromeXx_NEWLINE_xXParticipants with a known history of testing positive for Human Immunodeficiency Virus (HIV) or known Acquired Immunodeficiency Syndrome (AIDS)Xx_NEWLINE_xXPrimary immunodeficiencyXx_NEWLINE_xXPatients should be excluded if they have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS).Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome.Xx_NEWLINE_xXKnown Human Immunodeficiency Virus (HIV) or Acquired Immune Deficiency Syndrome (AIDS)Xx_NEWLINE_xXPrimary immunodeficiencyXx_NEWLINE_xXPatients with a known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) are ineligibleXx_NEWLINE_xXHistory of known active primary immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndromeXx_NEWLINE_xXHas known immunosuppressive disease (e.g. human immunodeficiency virus [HIV], acquired immunodeficiency syndrome [AIDS] or other immune depressing disease); testing is not required, only to be done for a possible diagnosis which is not confirmedXx_NEWLINE_xXKnown history of human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndromeXx_NEWLINE_xXKnown uncontrolled human immunodeficiency virus (HIV) infection or known acquired immunodeficiency syndrome (AIDS); patients with documented controlled HIV infection (CD4 > 200 and undetectable viral load) will be includedXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus or known acquired immunodeficiency syndrome.Xx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXHas a known history of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness, or hepatitis B or CXx_NEWLINE_xXHuman immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS)-related illnessXx_NEWLINE_xXhistory of testing positive to human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome;Xx_NEWLINE_xXAcquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocol; the need to exclude patients with AIDS from this protocol is necessaryXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS).Xx_NEWLINE_xXHas a diagnosis of immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXAny form of primary immunodeficiency.Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS).Xx_NEWLINE_xXIn order for patients with known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) to be eligible, they must be on a stable highly active antiretroviral therapy (HAART) regimen, have CD4 counts > 350, with no detectable viral load on quantitative polymerase chain reaction (PCR)Xx_NEWLINE_xXHuman immunodeficiency virus (HIV) seropositivity or other congenital or acquired immune deficiency state, which would increase the risk of opportunistic infections and other complications during chemotherapy-induced lymphodepletion; if there is a positive result in the infectious disease testing that was not previously known, the patient will be referred to their primary physician and/or infectious disease specialistXx_NEWLINE_xXHuman immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illnessXx_NEWLINE_xXKnown HIV or acquired immunodeficiency syndrome-related illness, acute or history of chronic hepatitis B or C.Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome.Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown significant immunodeficiency due to underlying illness (e.g. HIV/acquired immunodeficiency syndrome [AIDS]) and/or immune-suppressive medication including high-dose corticosteroids (defined as >= 20 mg/day prednisone or equivalent which is ongoing at the time of enrollment and/or was taken for more than 4 weeks within the preceding 2 months of enrollment)Xx_NEWLINE_xXHistory of active primary immunodeficiencyXx_NEWLINE_xXHistory of primary immunodeficiency.Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndromeXx_NEWLINE_xXHistory of active primary immunodeficiencyXx_NEWLINE_xXAny form of systemic immunodeficiency, including acquired deficiency such as HIV or primary immunodeficiency such as severe combined immunodeficiency diseaseXx_NEWLINE_xXAny form of primary immunodeficiency (such as Severe Combined Immunodeficiency Disease)Xx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) related illness.Xx_NEWLINE_xXCurrent active infections with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), hepatitis B, and hepatitis C requiring treatmentXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXHas a diagnosis of congenital immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus or known acquired\r\nimmunodeficiency syndromeXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) is not permittedXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXPatients are excluded if they have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS); appropriate studies will be undertaken in participants receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXPatients with known history of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS).Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndromeXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXPatients with known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) are excludedXx_NEWLINE_xXHistory of primary immunodeficiency.Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) even if fully immunocompetent on antiretroviral therapy (ART)—due to the unknown effects of HIV on the immune response to combined nivolumab plus ipilimumab or the unique toxicity spectrum of these drugs in patients with HIVXx_NEWLINE_xXKnown history of human immunodeficiency virus (HIV) or acquired immune deficiency syndrome (AIDS)Xx_NEWLINE_xXActive or history of uveal, mucosal, or ocular melanoma. Human immunodeficiency virus (HIV) or acquired immune deficiency syndrome (AIDS)-related illness, chronic hepatitis B or C.Xx_NEWLINE_xXHistory of any chronic Hepatitis, active Hepatitis B or C, human immunodeficiency virus (HIV), or acquired immune deficiency syndrome (AIDS)Xx_NEWLINE_xXHas a diagnosis of immunodeficiency, including human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown active human immunodeficiency virus (HIV), acquired immunodeficiency syndrome (AIDS) related illness, or hepatitis B or C infectionXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndromeXx_NEWLINE_xXHas a diagnosis of immunodeficiencyXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown severe congenital or acquired cellular or humoral immunodeficiency such as common variable immunodeficiency.Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV), or acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXActive uncontrolled infection, including known history of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) or hepatitis B or CXx_NEWLINE_xXHas a diagnosis of immunodeficiencyXx_NEWLINE_xXPatients with known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) might be enrolled if the viral load by PCR is undetectable with/without active treatment and absolute lymphocyte count >= 350/ulXx_NEWLINE_xXHas a history of primary immunodeficiencyXx_NEWLINE_xXAcquired immune deficiency syndrome (AIDS) based upon current Center for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocolXx_NEWLINE_xXHas known immunosuppressive disease (e.g. human immunodeficiency virus [HIV], acquired immune deficiency syndrome [AIDS] or other immune depressing disease); testing is not mandatoryXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXHas known immunodeficiency disease (e.g. human immunodeficiency virus [HIV], acquired immunodeficiency syndrome [AIDS]); has known hepatitis B or C; testing is not mandatoryXx_NEWLINE_xXKnown history of human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS)-related diseaseXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) is not permittedXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXDiagnosis of immunodeficiencyXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients, patients with acquired or congenital immunodeficiency conditions, those on chronic systemic immunosuppressants (requiring > 10 mg of prednisone or equivalent/day), those with active autoimmune disease are excluded from the studyXx_NEWLINE_xXHuman immunodeficiency virus (HIV) seropositivity or other congenital or acquired immune deficiency state; if there is a positive result in the infectious disease testing that was not previously known, the patient will be referred to their primary physician and/or infectious disease specialistXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXHuman immunodeficiency virus (HIV) virus infection irrespective of viral load, treatment status, or cluster of differentiation 4 (CD4) count, or acquired immunodeficiency syndrome (AIDS)-related illness; HIV testing is not required by this protocolXx_NEWLINE_xXHistory of active primary immunodeficiencyXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXThe subject has a history of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), chronic hepatitis B or hepatitis C or is otherwise reasonably suspected to meet criteria for the diagnosis of a known congenital or acquired disorder causing systemic immunosuppressionXx_NEWLINE_xXAny form of active primary or secondary immunodeficiencyXx_NEWLINE_xXActive infection (requiring oral or IV antibiotics or antiviral therapy) or other medical condition that would make prednisone/prednisolone (corticosteroid) use contraindicated; known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXMeasurable disease by the criteria proposed by the acquired immunodeficiency syndrome (AIDS) Clinical Trials Group Oncology Committee (for KS)Xx_NEWLINE_xXA recognized immunodeficiency disease including human immunodeficiency virus (HIV) infection (and other cellular immunodeficiencies, hypogammaglobulinemia or dysgammaglobulinemia; subjects who have hereditary, congenital or acquired immunodeficiencies).Xx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXPatients with human immunodeficiency virus (HIV) who are not receiving cytochrome p450 inhibitors, and who have a minimum of 300+ CD4+ cells/mm^3, an undetectable viral load, and no history of acquired immunodeficiency syndrome (AIDS) indicator conditionsXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness; (testing is not required for eligibility)Xx_NEWLINE_xXPatients should be excluded if they have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXPatients should be excluded if they have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXSignificant immunodeficiency making the patient unlikely to benefit from pembrolizumab therapy including a diagnosis of acquired immunodeficiency syndrome (AIDS), active hepatitis B or hepatitis C, or organ transplant requiring immunosuppressive therapyXx_NEWLINE_xXSubjects who require human immunodeficiency virus (HIV) protease inhibitors or those with acquired immune deficiency syndrome (AIDS)-related illnessXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illnessXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome-related diseaseXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) positivity or acquired immune deficiency syndrome (AIDS)-related illnessXx_NEWLINE_xXOther clinically significant disorders such as:\r\n* Known active infection requiring systemic treatment, infection with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness, chronic hepatitis B or known or suspected active hepatitis C infection\r\n* Serious non-healing wound or ulcer\r\n* Malabsorption syndrome\r\n* Symptomatic hypothyroidism\r\n* Moderate to severe hepatic impairment (Child-Pugh B or C)\r\n* Requirement for hemodialysis or peritoneal dialysis\r\n* History of solid organ transplantationXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXImmune deficiency: clinically significant primary or acquired immune deficiency (i.e. acquired immunodeficiency syndrome [AIDS] or on immunosuppressive medication after organ transplant)Xx_NEWLINE_xXPatients should be excluded if they have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown human immunodeficiency virus positive (HIV[+]) or has been diagnosed with acquired immune deficiency syndrome (AIDS)Xx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illnessXx_NEWLINE_xXPatients should be excluded if they have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHistory or evidence of sarcoma associated with immunodeficiency states (e.g.: hereditary immune deficiency, human immunodeficiency virus (HIV), organ transplant or leukemia)Xx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) related illnessXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown positive history or positive test for human immunodeficiency virus or acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown history of confirmed primary immunodeficiencyXx_NEWLINE_xXAcquired immune deficiency syndrome (AIDS) based upon current Centers for Disease and Control (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocol; protocol-specific requirements may also exclude immuno-compromised patientsXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXPatients with known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illnessXx_NEWLINE_xXKnown human immunodeficiency virus- or acquired immunodeficiency syndrome-related illness.Xx_NEWLINE_xXKnown human immunodeficiency virus (HIV) infection requiring antiretroviral medications and those with acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXActive uncontrolled infection, including known history of acquired immune deficiency syndrome (AIDS) or hepatitis B or CXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXPatients with known human immunodeficiency virus (HIV) positivity or acquired immunodeficiency syndrome (AIDS)-related illness are not eligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV) seropositivity or other congenital or acquired immune deficiency state, which would increase the risk of opportunistic infections and other complications during chemotherapy-induced lymphodepletion; if there is a positive result in the infectious disease testing that was not previously known, the patient will be referred to their primary physician and/or infectious disease specialistXx_NEWLINE_xXCOHORTS 1 AND 2: HEALTHY VOLUNTEERS: Subjects with a primary or acquired immunodeficiency, including human immunodeficiency virus (HIV) seropositivityXx_NEWLINE_xXCOHORT 3: ATOPIC DERMATITIS PATIENTS: Subjects with known primary or acquired immunodeficiencyXx_NEWLINE_xXPatients with acquired immunodeficiency syndrome (AIDS) developing EBV lymphomas or lymphoproliferative diseases as a consequence of the profound acquired immunodeficiency induced by human immunodeficiency virus (HIV); for such patients, EBV specific T-cells from third party seropositive donors who are HLA compatible in 1) at least 2 HLA antigens and 2) one restricted allele shared by the patient will be used; selection of T cells known to be restricted by an HLA allele shared by the patient will be given priorityXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXKnown significant immunodeficiency due to underlying illness (e.g., HIV/AIDS) and/or immune-suppressive medication including high-dose corticosteroidsXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHistory of immunodeficiency including seropositivity for human immunodeficiency virus (HIV), or other acquired or congenital immune-deficient disease, or any active systemic viral infection requiring therapy (e.g., hepatitis B or C)Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXHistory of active primary immunodeficiencyXx_NEWLINE_xXKnown history of human immunodeficiency virus (HIV) or acquired immunodeficiency-related (AIDS) illnesses.Xx_NEWLINE_xXPatients with known history of human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS)Xx_NEWLINE_xXHistory of testing positive to human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome;Xx_NEWLINE_xXKnown history of positive test for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome. Note: Testing for HIV must be performed at sites where mandated locally.Xx_NEWLINE_xXKnown significant immunodeficiency due to underlying illness (e.g. HIV/AIDS) and/or immunosuppressive medication including high-dose corticosteroids.Xx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness, active or symptomatic viral hepatitis or chronic liver diseaseXx_NEWLINE_xXSubject has history of primary immunodeficiencyXx_NEWLINE_xXEvidence of immune suppression due to: a) known human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS); b) known leukemia or lymphoma; c) those who require high dose steroids (> 10 mg/day of prednisone or equivalent within 7 days prior to enrollment) or other immunosuppressive therapies (> 2 weeks); d) active hepatitis B or C; e) congenital or acquired cellular and/or humoral immune deficiency; f) other signs or symptoms of immune system suppression or concurrent opportunistic infectionXx_NEWLINE_xXHistory of active primary immunodeficiencyXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXHistory of primary immunodeficiency.Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown history of human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS).Xx_NEWLINE_xXHistory of organ allograft or other history of immunodeficiencyXx_NEWLINE_xXKnown positive testing for human immunodeficiency virus (HIV)or history of acquired immune deficiency syndrome (AIDS).Xx_NEWLINE_xXPatients with acquired immunodeficiency syndrome (AIDS-related illnesses) or known human immunodeficiency virus (HIV) disease must:\r\n* Have a cluster of differentiation (CD)4 count >= 200 cells/uL within 30 days before beginning study therapy\r\n* Be off all antiretroviral therapy (prophylaxis/treatment) more than 60 days before beginning study therapy, and\r\n* Have no evidence of opportunistic infectionsXx_NEWLINE_xXHistory of active primary immunodeficiency including, but not limited to acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; Note: human immunodeficiency virus (HIV) testing is not required for entry into this protocol; the need to exclude patients with AIDS from this protocol is necessary because the treatment involved in this protocol may be immunosuppressive; patients with known HIV, CD4 counts >= 200/uL, and undetectable viral loads who are stable on an antiretroviral regimen may be includedXx_NEWLINE_xXThe subject has a history of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), chronic hepatitis B or hepatitis C or is otherwise reasonably suspected to meet criteria for the diagnosis of a known congenital or acquired disorder causing systemic immunosuppressionXx_NEWLINE_xXKnown medical history of testing positive for human immunodeficiency virus (HIV) or known medical history of acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXDiagnosis of immunodeficiencyXx_NEWLINE_xXKnown history of human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXPatients with a known human immunodeficiency virus infection (HIV 1/2 antibodies) or acquired immunodeficiency syndrome (HIV/AIDS)Xx_NEWLINE_xXPrimary or secondary immunodeficiency (history of or currently active) unless related to primary disease under investigationXx_NEWLINE_xXSubjects should be excluded if they have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS).Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXDiagnosis of immunodeficiencyXx_NEWLINE_xXHas a diagnosis of immunodeficiencyXx_NEWLINE_xXHistory of immunodeficiency or autoimmune disease: patients with a history of immunodeficiency, including organ grafts and human immunodeficiency virus (HIV), will not be eligibleXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXPatients known to be human immunodeficiency virus (HIV) positive with a baseline cluster of differentiation (CD)4 count of < 250 cells/mm^3 or have a history of acquired immune deficiency syndrome (AIDS) indicator conditions; patients taking anti-retroviral therapy that may have a potential overlapping toxicity with the study therapy are not eligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV) positive serology or acquired immune deficiency syndromeXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients and those with other acquired/inherited immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXPatients must not have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) even if fully immunocompetent on ART—due to the unknown effects of HIV on the immune response to combined nivolumab plus ipilimumab or the unique toxicity spectrum of these drugs in patients with HIVXx_NEWLINE_xXHuman Immunodeficiency Virus/Acquired Immunodeficiency Syndrome((HIV/AIDS)Xx_NEWLINE_xXHave human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome-related illness.Xx_NEWLINE_xXSubject has any history of testing positive for Human Immunodeficiency Virus (HIV) or known acquired immunodeficiency disorder (AIDS).Xx_NEWLINE_xXPatients should be excluded if they have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) (testing not mandatory)Xx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness or other active infection; patients with HIV but no evidence of AIDS will be considered candidatesXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) positivity or autoimmune deficiency syndrome (AIDS)-related illnessXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) related illnessXx_NEWLINE_xXPatients must not have any history of primary immunodeficiencyXx_NEWLINE_xXSubject has primary or acquired immunodeficiency or known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome;Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXHistory of primary immunodeficiency.Xx_NEWLINE_xXAbsence of history of acquired immune deficiency syndrome (AIDS)-related conditions (other than the presenting DLBCL) or post-transplant lymphoproliferative disorder (PTLD) in immunocompromised patients; patients with human immunodeficiency virus (HIV) on antiretroviral therapy other than zidovudine (AZT) and/or stavudine and without prior AIDS defining conditions and adequate CD4 count (> 400) are eligibleXx_NEWLINE_xXIf there is clinical suspicion of acquired immunodeficiency syndrome (AIDS), a human immunodeficiency virus (HIV) test is recommended within 42 days prior to registration; Note: HIV positive patients without AIDS are eligible for enrollment on this studyXx_NEWLINE_xXAcquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; patients with known AIDS will be ineligible for this protocol; patients with clinical suspicion of AIDS and who are unwilling to have an HIV test are not eligible for this trialXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) related illnessXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHistory of prior immunodeficiencyXx_NEWLINE_xXEvidence of immune suppression due to: \r\n* Known human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS)\r\n* Known leukemia or lymphoma\r\n* Those who require high dose steroids or other immunosuppressive agents\r\n* Known hepatitis B or C infection \r\n* Congenital or acquired cellular and/or humoral immune deficiency\r\n* Other signs or symptoms of immune system suppressionXx_NEWLINE_xXIn order for patients with known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) to be eligible, they must be on a stable highly active antiretroviral therapy (HAART) regimen, have cluster of differentiation (CD)4 counts > 350, with no detectable viral load on quantitative polymerase chain reaction (PCR)Xx_NEWLINE_xXHuman immunodeficiency virus (HIV) infection without acquired immune deficiency syndrome (AIDS)-defining criteria are eligibleXx_NEWLINE_xXAcquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocolXx_NEWLINE_xXAny form of active primary or secondary immunodeficiencyXx_NEWLINE_xXKnown human immunodeficiency virus infection or acquired immunodeficiency syndrome-related illness.Xx_NEWLINE_xXHuman immunodeficiency virus (HIV) seropositivity or other congenital or acquired immune deficiency state, which would increase the risk of opportunistic infections and other complications during chemotherapy-induced lymphodepletion; if there is a positive result in the infectious disease testing that was not previously known, the patient will be referred to their primary physician and/or infectious disease specialistXx_NEWLINE_xXClinically significant autoimmune disorders or conditions of immunosuppression; patients with acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV)-1 associated complex or known to be HIV antibody seropositive or known to be recently polymerase chain reaction (PCR)+ for hepatitis B or C are not eligible for this study; the severely depressed or altered immune system found in these patients and the possibility of premature death would compromise study objectivesXx_NEWLINE_xXPatients with human immunodeficiency virus (HIV) who are not receiving cytochrome p450 inhibitors, and who have a minimum of 300+ CD4+ cells/mm^3, an undetectable viral load, and no history of acquired immune deficiency syndrome (AIDS) indicator conditionsXx_NEWLINE_xXSubject has a known active hepatitis B or C infection, Human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHuman immunodeficiency virus (HIV) seropositivity or other congenital or acquired immune deficiency state, which would increase the risk of opportunistic infections and other complications during chemotherapy-induced lymphodepletion; if there is a positive result in the infectious disease testing that was not previously known, the patient will be referred to their primary physician and/or infectious disease specialistXx_NEWLINE_xXDocumented history of human immunodeficiency virus (HIV) positivity or other acquired immunodeficiency disorder, congenital immunodeficiency disorder, or history of organ transplantationXx_NEWLINE_xXParticipant has known human immunodeficiency virus infection or acquired immunodeficiency syndrome-related illnessXx_NEWLINE_xXHistory of human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS)-related illnessXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) within 12 months prior to initiating study treatmentXx_NEWLINE_xXKnown history of positive test for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXPatients with any form of active primary or secondary immunodeficiency.Xx_NEWLINE_xXHas a diagnosis of immunodeficiencyXx_NEWLINE_xXPrimary immunodeficiencyXx_NEWLINE_xXKnown positive testing for human immunodeficiency virus or history of acquired immune deficiency syndromeXx_NEWLINE_xXPatients should be excluded if they have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS).Xx_NEWLINE_xXPatients are excluded if they have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXPrimary or secondary immunodeficiency (history of or currently active) unless related to primary disease under investigationXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) related illnessXx_NEWLINE_xXPatients who are known to be positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) are not eligibleXx_NEWLINE_xXSubject has a documented severe congenital or acquired immunodeficiency;Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXPatients with known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) is not permittedXx_NEWLINE_xXHas human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS)-related illness, or a history of immunodeficiencyXx_NEWLINE_xXHas a known diagnosis of immunodeficiency (human immunodeficiency virus [HIV] 1/2 antibodies) or any other form of immunosuppressive therapy within 7 days prior to the first dose of trial treatment excluding steroids; attempts should be made to have patient on lowest possible dose of steroidsXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus or known acquired immunodeficiency syndromeXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) positivity or acquired immunodeficiency syndrome (AIDS) related illness or other serious medical illnessXx_NEWLINE_xXHistory of active primary immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown history of testing positive for human Immunodeficiency virus (HIV) or known acquired Immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXDiagnosis of immunodeficiencyXx_NEWLINE_xXHas a diagnosis of immunodeficiencyXx_NEWLINE_xXHistory of active primary immunodeficiency;Xx_NEWLINE_xXHas a known human immunodeficiency virus infection (HIV 1/2 antibodies) or acquired immunodeficiency syndrome (HIV/AIDS)Xx_NEWLINE_xXKnown human immunodeficiency virus positive (HIV)(+) or has been diagnosed with acquired immune deficiency syndrome (AIDS)Xx_NEWLINE_xXAcquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition or known human immunodeficiency virus (HIV) seropositivity; note, however, that HIV testing is not required for entry into this protocolXx_NEWLINE_xXHistory of active primary immunodeficiencyXx_NEWLINE_xXKnown immunodeficiency disordersXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illnessXx_NEWLINE_xXKnown human immunodeficiency virus positivity or acquired immunodeficiency syndrome related illness or other serious medical conditionXx_NEWLINE_xXHuman immunodeficiency virus (HIV) infection or immunodeficiency disorders, either primary or acquiredXx_NEWLINE_xXSubjects with known infection with human immunodeficiency virus (HIV) or Acquired Immune Deficiency Syndrome (AIDS)Xx_NEWLINE_xXPatients with acquired immunodeficiency syndrome (AIDS-related illnesses) or known human immunodeficiency virus (HIV) disease must: Have a CD4 count greater than or equal to 200 cells/uL within 30 days prior to beginning study therapy; Be off all antiretroviral therapy (prophylaxis/treatment) greater than 60 days prior to beginning study therapy; Have no evidence of opportunistic infections.Xx_NEWLINE_xXPatients with a recognized acquired, hereditary, or congenital immunodeficiency disease including cellular immunodeficiency’s, hypogammaglobulinemia or dysgammaglobulinemiaXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHistory of genetic or acquired immune suppression disease such as human immunodeficiency virus (HIV); subjects on immune suppressive therapy for organ transplantXx_NEWLINE_xXKnown HIV or other history of immunodeficiency disorder.Xx_NEWLINE_xXSubjects who require human immunodeficiency virus (HIV) protease inhibitors or those with acquired immune deficiency syndrome (AIDS)-related illnessXx_NEWLINE_xXPatients with an immunodeficiency that existed prior to diagnosis, such as primary immunodeficiency syndromes, organ transplant recipients and children on current systemic immunosuppressive agents are not eligibleXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown chronic infectious disease including, but not limited to, human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS)Xx_NEWLINE_xXKnown acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition or other acquired or congenital disorder of the immune systemXx_NEWLINE_xXPatients with congenital immunodeficiency, chromosomal breakage syndrome, prior organ transplantation, previous malignancy of any type, or known positive human immunodeficiency virus (HIV) serologyXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness or other active infectionXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXPatients with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) are allowed on study if they have an undetectable viral load, cluster of differentiation (CD)4 > 300 and on stable highly active antiretroviral therapy (HAART) regimen for 1 monthXx_NEWLINE_xXE 12. Acquired immunodeficiency syndrome (AIDS-related illnesses) or known HIV disease requiring antiretroviral treatment.Xx_NEWLINE_xXFor patients with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS), the following must be true:\r\n* The patient is compliant on combination anti-retroviral therapy (CART)\r\n* The patient has cluster of differentiation (CD)4 count >= 200 at time of diagnosisXx_NEWLINE_xXPatients should be excluded if they have a known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome, or need to receive combination antiretroviral therapy for HIVXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS).Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXSerious uncontrolled infection; known human immunodeficiency virus (HIV)-seropositivity requiring retroviral therapy, or diagnosis of acquired immune deficiency syndrome (AIDS); diagnosis of chronic hepatitis B or C allowedXx_NEWLINE_xXAny form of active primary or secondary immunodeficiencyXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXSubjects with known infection with human immunodeficiency virus (HIV) or Acquired Immune Deficiency Syndrome (AIDS) (testing not required).Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXPositive test for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXKnown history of of human immunodeficiency virus (HIV); patients with acquired immunodeficiency syndrome (AIDS) are excludedXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)\r\n* Note – screening tests are not required unless suspected infection or as clinically indicatedXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illnessXx_NEWLINE_xXHuman immunodeficiency virus (HIV)+/acquired immune deficiency syndrome (AIDS)Xx_NEWLINE_xX6. Subjects with known infection with human immunodeficiency virus or Acquired Immune Deficiency Syndrome (testing not required).Xx_NEWLINE_xXHas known human immunodeficiency virus or acquired immune deficiency syndrome, hepatitis B, hepatitis C, connective tissue disease, or other clinical diagnosis, ongoing or intercurrent illness that in the Investigators opinion should preclude the subject from participation;Xx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXPatients seropositive for the human immunodeficiency virus (HIV), and/or those who are taking anti-retroviral treatment for HIV/acquired immune deficiency syndrome (AIDS)Xx_NEWLINE_xXPatients with known history of human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS)Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus or known acquired immunodeficiency syndrome.Xx_NEWLINE_xXKnown human immunodeficiency virus (HIV) positive or history of acquired immune deficiency syndrome (AIDS) or AIDS-defining illnessXx_NEWLINE_xXEvidence of ongoing systemic bacterial, fungal, or viral infection. Known human immunodeficiency virus (HIV) infection or acquired-immunodeficiency syndrome (AIDS)-related illnessXx_NEWLINE_xXAcquired immunodeficiency syndrome (AIDS)-related illnesses or known Human immunodeficiency virus (HIV) disease requiring antiretroviral treatment.Xx_NEWLINE_xXPatients with acquired immunodeficiency syndrome (AIDS) or who are known to be human immunodeficiency virus (HIV) positive are not eligible for this study; testing may have been done up to 3 months prior to treatmentXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXAcquired immuno deficiency syndrome (AIDS-related illnesses) or known human immunodeficiency virus (HIV) disease requiring antiretroviral treatmentXx_NEWLINE_xXPatients with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) are allowed on study if they have an undetectable viral load, cluster of differentiation (CD)4 > 300 and are on a stable highly active antiretroviral therapy (HAART) regimen for 1 month prior to study enrollmentXx_NEWLINE_xXKnown human immunodeficiency virus-positive serology, acquired immunodeficiency syndrome (AIDS), or an AIDS-related illness.Xx_NEWLINE_xXPositive test for human immunodeficiency virus (HIV) 1&2 or known Acquired immune deficiency syndrome (AIDS)Xx_NEWLINE_xXKnown to be human immunodeficiency virus (HIV) positive or with known acquired immunodeficiency syndrome (AIDS) syndromeXx_NEWLINE_xXAcquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocolXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease and acquired immune deficiency syndrome [AIDS])Xx_NEWLINE_xXChronic or current active infectious disease requiring systemic antibiotics, antifungal, or antiviral treatment such as, but not limited to, chronic renal infection, chronic chest infection with bronchiectasis, tuberculosis, active Hepatitis C, and known Human Immunodeficiency Virus (HIV) disease. All HIV-positive subjects are excluded from this study, regardless of whether they have an Acquired Immunodeficiency Syndrome (AIDS) defining disease and/or are on antiviral therapy.Xx_NEWLINE_xXPatients with an immunodeficiency syndromeXx_NEWLINE_xXPresence of human immunodeficiency virus (HIV) infection or acquired immune deficiency syndrome (AIDS)Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXAny form of active primary or secondary immunodeficiencyXx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXAny form of primary immunodeficiency (such as severe combined immunodeficiency disease)Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) related illness, which may compromise the efficacy of immunostimulatory therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXCo-morbidity with immunosuppressive disease such as acquired immune deficiency syndrome (AIDS)Xx_NEWLINE_xXKnown positive testing for human immunodeficiency virus or history of acquired immune deficiency syndromeXx_NEWLINE_xXPositive test result for human immunodeficiency virus (HIV) or acquired immune deficiency syndrome (AIDS)Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHuman immunodeficiency virus infection or acquired immunodeficiency syndrome-related illness.Xx_NEWLINE_xXHuman immunodeficiency virus or acquired immunodeficiency syndromeXx_NEWLINE_xXCoexisting cancer in other organs or acquired immunodeficiency syndrome/human immunodeficiency virus (AIDS/HIV)Xx_NEWLINE_xXHistory or serologic evidence of chronic viral infection (hepatitis B or C), human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS)Xx_NEWLINE_xXKnown history of Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS), hepatitis B or C.Xx_NEWLINE_xXAcquired immunosuppressive diseases such as active human immunodeficiency virus (HIV) infection or congenital diseases of immunityXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXHistory of primary immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndromeXx_NEWLINE_xXSubject has history of primary immunodeficiencyXx_NEWLINE_xXImmune compromised individuals (human immunodeficiency virus [HIV], acquired immune deficiency syndrome [AIDS], immuno-suppressive drug therapy)Xx_NEWLINE_xXHas been diagnosis of active acquired immunodeficiency syndrome (AIDS) or hepatitis B/C and other significant disease or disordersXx_NEWLINE_xXHistory of or currently active primary or secondary immunodeficiency.Xx_NEWLINE_xXSubjects must not have a history of primary immunodeficiency.Xx_NEWLINE_xXPrimary immunodeficiencyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndromeXx_NEWLINE_xXKnown positive testing for human immunodeficiency virus or history of acquired immune deficiency syndrome.Xx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndromeXx_NEWLINE_xXPatients with major chronic disease known to adversely affect PA, including human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS), congestive heart failure, tuberculosisXx_NEWLINE_xXPositive test for human immunodeficiency virus (HIV) 1&2 or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXPatients with a known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) will be eligible if:\r\n* They are generally healthy from an HIV perspective and on a stable anti-retroviral regimen for > 6 months\r\n* They have had no AIDS-defining conditions in the past 12 months other than historically low CD4+ cell counts\r\n* They have an undetectable viral load on standard assaysXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) related illnessXx_NEWLINE_xX