Patients must have a Lansky or Karnofsky performance status score of >= 50, corresponding to Eastern Cooperative Oncology Group (ECOG) categories 0, 1 or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0 or 1\r\n* Use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 60 for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age \r\n* Note: Neurologic deficits in patients with CNS tumors must have been relatively stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age \r\n* Note: Neurologic deficits in patients with CNS tumors must have been relatively stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; Note: Neurologic deficits in patients with CNS tumors must have been relatively stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; note: neurologic deficits in patients with CNS tumors must have been relatively stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXAdequate performance status: children < 10-Lansky score >= 30; children >= 10-Karnofsky >= 30 (except for posterior fossa syndrome)Xx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; NOTE: neurologic deficits in patients with CNS tumors must have been relatively stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1 or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXLansky performance status score >= 70 for patients =< 16 years of ageXx_NEWLINE_xXKarnofsky performance status score >= 70 for patients > 16 years of ageXx_NEWLINE_xXLansky performance status score >= 50 for patients =< 16 years of age; Karnofsky performance status score >= 50 for patients > 16 years of ageXx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1, or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXPatients must have a Lansky or Karnofsky performance status score of >= 50, corresponding to Eastern Cooperative Oncology Group (ECOG) categories 0, 1 or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age\r\n* Note: Neurologic deficits in patients with CNS tumors must have been relatively stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; Note: neurologic deficits in patients with CNS tumors must have been stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; Note: Neurologic deficits in patients with CNS tumors must have been stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age\r\n* Note: Neurologic deficits in patients with CNS tumors must have been relatively stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; Note: neurologic deficits in patients with CNS tumors must have been relatively stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; Note: neurologic deficits in patients with CNS tumors must have been stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1, or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXLansky or Karnofsky Score must be ? 50Xx_NEWLINE_xXLansky performance status >= 50Xx_NEWLINE_xXHave a Karnofsky performance status greater than or equal to 50 for patients aged 16 years or older and a Lansky performance status greater than or equal to 50 for patients less than 16 years oldXx_NEWLINE_xXKarnofsky scores < 60 or Lansky score < 50Xx_NEWLINE_xXEastern Cooperative Oncology Group (ECOG) performance status ? 3 for subjects aged > 16 years; Lansky score ? 20 for subjects from birth to 16 yearsXx_NEWLINE_xXPerformance status\r\n* Phase I: Karnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within one week of enrollment must be >= 50\r\n* Surgical study: Karnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within one week of enrollment must be >= 60\r\n* Patients who are unable to walk because of neurologic deficits, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50% for patients =< 16 years of age; Note: Neurologic deficits in patients with metastatic CNS tumors must have been relatively stable for a minimum of 1 week prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPatients must have a Lansky (?16 years) or Karnofsky (> 16 years) score of at least 50Xx_NEWLINE_xXKarnofsky/Lansky performance score ? 60Xx_NEWLINE_xXHave a Lansky score ? 40 for subjects up to 16 years of age or a Karnofsky score ? 40 for subjects 16 years of age to < 18 yearsXx_NEWLINE_xXLansky (for research participants =< 16 years) or Karnofsky (for research participants > 16 years) performance score >= 40 at the time of study enrollmentXx_NEWLINE_xXKarnofsky >= 50% for subjects > 16 years of age and Lansky >= 50 for subjects =< 16 years of age; Note: subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXLansky >= 50% for patients =< 10 years of age or Karnofsky >= 50% for patients > 10 years of ageXx_NEWLINE_xXTREATMENT: Patients with a Karnofsky/Lansky score of >= 50%Xx_NEWLINE_xXPatients must have a Karnofsky performance status of greater than or equal to 50 for patients older than 16 years of age or Lansky performance status of greater than or equal to 50 for patients less than or equal to 16 years of age.Xx_NEWLINE_xXIPSS score <= 16.Xx_NEWLINE_xXKarnofsky >= 50% for patients > 10 years of ageXx_NEWLINE_xXLansky >= 50 for patients =< 10 years of age or as per institutional guidelines; Note: Patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPatients with a Karnofsky score of >= 50Xx_NEWLINE_xXAdequate performance status: Karnofsky ? 50 for patients ? 16 years of ageXx_NEWLINE_xXAdequate performance status: Lansky ? 50 for patients < 16 years of ageXx_NEWLINE_xXPatients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXSubjects > 10 years of age: Karnofsky >= 50%; Subjects =< 10 years of age: Lansky scale >= 50%Xx_NEWLINE_xXPerformance status Lansky (age < 16) or Karnofsky score (age >= 16) >= 80%Xx_NEWLINE_xXPerformance status: Lansky >= 50 for patients who are =< 16 years old and Karnofsky >= 50% for patients who are > 16 years oldXx_NEWLINE_xXINCLUSION - TREATMENT: Karnofsky or Lansky score of > 60%Xx_NEWLINE_xXEastern Cooperative Oncology Group (ECOG) performance status =< 2 or Karnofsky > 50% (if >= 16 years of age); or children < 16 years old must have a Lansky performance of >= 50%Xx_NEWLINE_xXPatients must have a Lansky or Karnofsky performance status score of >= 50, corresponding to Eastern Cooperative Oncology Group (ECOG) categories 0, 1 or 2. Use Karnofsky for subjects >= 16 years of age and Lansky for subjects <= 16 years of age.Xx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky performance status >= 50% for patients > 16 years of age and Lansky >= 50 for patients =<16 years of age; Note: neurologic deficits in patients with CNS tumors must have been relatively stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPatient must have a Karnofsky (if >= 16 years of age) or Lansky performance score (if =< 15 years of age) of >= 50 by the time of registration; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky performance scale ([KPS] for > 16 yrs of age) or Lansky performance score ([LPS] for =< 16 years of age) >= 50Xx_NEWLINE_xXKarnofsky performance scale (KPS for >= 16 years of age) or Lansky performance score (LPS for =< 15 years of age) >= 60 assessed within 14 days prior to registrationXx_NEWLINE_xXLansky Play Scale ?50 for participants from 6 months up to and including 16 years of age; or Karnofsky score ?50 for participants >16 years of ageXx_NEWLINE_xXKarnofsky >= 50 for patients >= 16 years of age, and Lansky >= 50 for patients < 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXINCLUSION - INFUSION: Patients with a Karnofsky/Lansky score of ? 60Xx_NEWLINE_xXPROCUREMENT INCLUSION: Karnofsky or Lansky score of > 60%Xx_NEWLINE_xXTREATMENT INCLUSION: Karnofsky or Lansky score of > 60%Xx_NEWLINE_xXParticipants with lansky-Karnofsky score of greater than or equal to (>=) 50Xx_NEWLINE_xXPatient may not have a Karnofsky performance score < 50% or Lansky performance score < 50%Xx_NEWLINE_xXLansky score <50%Xx_NEWLINE_xXKarnofsky/Lansky score of ? 50Xx_NEWLINE_xXPerformance status: Karnofsky/Lansky score > 50%.Xx_NEWLINE_xXKarnofsky/Lansky score of ? 50Xx_NEWLINE_xXPerformance status >= 50% (Lansky for =<12ys; Karnofsky for >12ys)Xx_NEWLINE_xXKarnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within two weeks of enrollment must be >= 70; patients who are unable to walk because of neurologic deficits, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXINCLUSION CRITERIA FOR STRATUM C: Karnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within two weeks of enrollment must be >= 60; patients who are unable to walk because of neurologic deficits, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPatients >= 16 years of age: Karnofsky >= 50%; patients =< 16 years of age: Lansky scale >= 50%; subjects who are unable to walk because of paralysis, but who are upright in a wheelchair will be considered ambulatory for the purpose of calculating the performance scoreXx_NEWLINE_xXELIGIBILITY CRITERIA AT TIME OF TREATMENT: Patients with a Karnofsky/Lansky score of ? 50Xx_NEWLINE_xXKarnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within two weeks of enrollment must be >= 60Xx_NEWLINE_xXPatients with a Karnofsky/Lansky score of ? 50Xx_NEWLINE_xXKarnofsky (> 16 years of age) or Lansky (=< 16 years of age) performance status (PS) 60–100%; Note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky/Lansky score ? 50%Xx_NEWLINE_xXPatients must have a Lansky performance status score of >= 50 or a Karnofsky score of >= 50 for patients >= 16 years of age; Note: Patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPatients must have a Lansky or Karnofsky performance status score of >= 50; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXINCLUSION - PROCUREMENT: Karnofsky/Lansky score of ? 50Xx_NEWLINE_xXINCLUSION - TREATMENT: Karnofsky/Lansky score of ? 50Xx_NEWLINE_xXPerformance level corresponding to Eastern Cooperative Oncology Group (ECOG) score of 0, 1, or 2; the Lansky performance score should be used for participants < 16 yearsXx_NEWLINE_xXPatient must have a Karnofsky performance status or Lansky* play status >= 50\r\n* For purpose of determining performance scores, wheelchair-bound patients will be considered ambulatoryXx_NEWLINE_xXSubjects must have a performance status of > 50%; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXAUTOLOGOUS APHERESIS: Karnofsky or Lansky (age-dependent) performance score >= 50Xx_NEWLINE_xXMANUFACTURING SJCAR19: Karnofsky or Lansky (age-dependent) performance score >= 50Xx_NEWLINE_xXTREATMENT WITH SJCAR19: Karnofsky or Lansky (age-dependent) performance score >= 50Xx_NEWLINE_xXKarnofsky >= 50 for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age. Patients who are unable to walk because of paralysis, but who are able to mobilize using a wheelchair, will be considered ambulatory for the purpose of assessing the performance score.Xx_NEWLINE_xXKarnofsky or Lansky performance score is ? 50% (corresponding to Eastern Cooperative Oncology Group [ECOG] score of ? 2); the Lansky performance score should be used for participants < 16 years and the Karnofsky performance score for participants ? 16 years; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXClinical performance status: Patients > 16 years of age: Karnofsky ? 50%; patients < 16 years of age: Lansky scale ? 50%; subjects who are unable to walk because of paralysis, but who are upright in a wheelchair will be considered ambulatory for the purpose of calculating the performance scoreXx_NEWLINE_xXSTRATUM A: Participants must have a Lansky (=< 16 years) or Karnofsky (> 16 years) score of at least 50 at the time of study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXSTRATUM B: Participants must have a Lansky (=< 16 years) or Karnofsky (> 16 years) score of at least 50 at the time of study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXSTRATUM C: Participants must have a Lansky (=< 16 years) or Karnofsky (> 16 years) score of at least 50 at the time of study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky ? 50 for patients ? 16 years of age, and Lansky ? 50 for patients < 16 years of age.Xx_NEWLINE_xXPerformance status: Lansky Play-Performance Scale ?50 for children up to and including 16 years of age OR Karnofsky score ?50 for participants >16 years of ageXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; Note: neurologic deficits in patients with CNS tumors must have been relatively stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPerformance score > 70% (use Lansky score for age < 16 and Karnofsky score for age >= 16)Xx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; Note: Neurologic deficits in patients with CNS tumors must have been relatively stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky or Lansky (subjects <16 years) performance status ?60Xx_NEWLINE_xXThe participant has a Lansky (<16 years of age) or Karnofsky (?16 years of age) performance score of at least 50.Xx_NEWLINE_xXPerformance score using the Karnofsky performance scale (patients > 12 years old) or Lansky Play - performance scale (patients =< 12 years old) must be >= 60 assessed within two weeks prior to enrollmentXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years old, and Lansky >= 50 for patients 1-16 years oldXx_NEWLINE_xXKarnofsky performance scale (KPS for > 16 years [yrs.] of age) or Lansky performance score (LPS for =< 16 years of age) >= 60 assessed within two weeks prior to registrationXx_NEWLINE_xXKarnofsky > 50% for patients > 16 years of age and Lansky > 50% for patients < 16 years of age; neurologic deficits in patients with central nervous system (CNS) tumors must have been relatively stable for a minimum of 7 days; patients who are unable to walk because of paralysis, but who are able to sit in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXHave a Karnofsky (adult) or Lansky (for =< 16 years) performance status >= 60%Xx_NEWLINE_xXSubjects must have a Lansky performance status score of >= 50 or a Karnofsky score of >= 50 for subjects >= 16 years of age; Note: Subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPatients must have a Karnofsky >= 50% for subjects > 16 years of age and Lansky score >= 50 for subjects =< 16 years of age \r\n* Note: Subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky performance status (KPS) of > 60% (KPS for > 10 years of age) or Lansky performance Score (LPS) of >= 60 (LPS for =< 10 years of age) assessed within 2 weeks prior to registration; patients who are unable to walk because of paralysis but who are up in a wheel chair will be considered ambulatory for the purposes of the performance scoreXx_NEWLINE_xXLansky or Karnofsky performance score >= 60Xx_NEWLINE_xXAdequate performance status as follows\r\n* Patients >= 16 years must have Eastern Cooperative Oncology Group (ECOG) performance status 0-2 (Karnofsky >= 60%)\r\n* Pediatric patients < 16 years must have Lansky play-performance of 60-100%Xx_NEWLINE_xXSubject has Karnofsky (age ? 16 years) or Lansky (age < 16 years) performance status score ? 50 at screeningXx_NEWLINE_xXAdequate performance status (PS) as follows:\r\n* Patients >= 16 years must have Eastern Cooperative Oncology Group (ECOG) PS 0-1 and Karnofsky >= 60%\r\n* Pediatric patients < 16 years must have Lansky play-performance of 60\r\n** NOTE: Patients >= 16 years with an ECOG PS of 2 and Karnofsky >= 60 will be considered eligible at the discretion of the principal investigator if decreased ECOG performance status is felt to be related to residual neurologic deficits caused by CNS disease involvement that are not progressive or anticipated to cause clinical management problems during study participationXx_NEWLINE_xXKarnofsky scores < 60 or Lansky score < 50Xx_NEWLINE_xXParticipant's performance score must be ?50% Karnofsky (for participants >16 years of age) or Lansky (for participants less than or equal to (?)16 years of age).Participants who are unable to walk because of paralysis and/or previous surgeries, but who are in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score.Xx_NEWLINE_xXSubjects must have a Lansky performance status score of >= 50 or a Karnofsky score of >= 50 for subjects >= 16 years of age; Note: subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky > 50 for patients > 16 years of age and Lansky > 50 for patients =< 16 years of ageXx_NEWLINE_xXPatients must have a Lansky performance status score of >= 50, or a Karnofsky score of >= 50 for patients >= 16 years of age; Note: Patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXEastern Cooperative Oncology Group (ECOG) performance status =< 2 or Karnofsky >= 60% in patients > 16 years of age, Lansky >= 60 for patients =< 16 years of ageXx_NEWLINE_xXKarnofsky performance status >= 80% for patients >= 16 years of age or Lansky play score >= 80 for patients < 16 years of age\r\n* Note: if poor performance status is due to lymphoma - Karnofsky performance status (KPS) >= 60% or Lansky performance score (LPS) >= 60 is acceptableXx_NEWLINE_xXEastern Cooperative Oncology Group (ECOG) =< 2 (patients >= 16 years of age must have a Karnofsky performance level of >= 70% [or ECOG =< 2], and children < 16 years old must have a Lansky performance of >= 70%)Xx_NEWLINE_xXPerformance score of at least 80% by Karnofsky or performance score (PS) < 3 (Eastern Cooperative Oncology Group [ECOG]) (age >= 12 years), or Lansky play-performance scale of at least 60% or greater (age < 12 years).Xx_NEWLINE_xXEastern Cooperative Oncology group (ECOG) =< 2 for patients >= 16 years old or Lansky play >= 60% for patients\r\n=< 15 years oldXx_NEWLINE_xXKarnofsky >= 50 for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXSubjects must have Karnofsky >= 50%; Note: subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXMinimal limitation on activities of daily living as measured by Karnofsky ? 50 for participants > 16 years of age or Lansky ? 50 for participants ? 16 years of age.Xx_NEWLINE_xXPerformance status: Lansky or Karnofsky score ? 60% and minimum life expectancy of at least 4 weeksXx_NEWLINE_xXCELL PROCUREMENT: Karnofsky score > 60% if >= 16 years old or Lansky performance score of greater than 60% if < 16 years oldXx_NEWLINE_xXLYMPHODEPLETION: Karnofsky score > 60% if >= 16 years old or Lansky performance score of greater than 60% if < 16 years oldXx_NEWLINE_xXKarnofsky score (adults) < 60% or Lansky score < 50% (pediatrics)Xx_NEWLINE_xXAdequate performance status is defined as Karnofsky score >= 70% (> 16 years of age) or Lansky score >= 70 (pediatrics)Xx_NEWLINE_xXPerformance level: \r\n* Lansky score >= 60% (patients < 16 years of age)\r\n* Karnofsky score >= 60% (patients >= 16 years of age)Xx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age\r\n* Note: Neurologic deficits in patients must have been relatively stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky or Lansky (age-dependent) performance score >= 50Xx_NEWLINE_xXPART 2 GROUP 1 INCLUSION CRITERIA: Performance status:\r\n* Karnofsky score >= 50 for subjects >16 years of age\r\n* Lansky score >= 50 for subjects =< 16 years of age\r\n* Note: subjects who are unable to walk because of paralysis, but who are mobile in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPART 2 GROUP 2A INCLUSION CRITERIA: Performance status:\r\n* Karnofsky score >= 50 for subjects >16 years of age\r\n* Lansky score >= 50 for subjects =< 16 years of age\r\n* Note: subjects who are unable to walk because of paralysis, but who are mobile in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPART 2 GROUP 3 INCLUSION CRITERIA: Performance status:\r\n* Karnofsky score >= 50 for subjects >16 years of age\r\n* Lansky score >= 50 for subjects =< 16 years of age\r\n* Note: subjects who are unable to walk because of paralysis, but who are mobile in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky score of >= 50 for patients > 16 years of age; orXx_NEWLINE_xXLansky score of >= 50 for patients =< 16 years of ageXx_NEWLINE_xXKarnofsky performance status score (age >= 16 years) or Lansky play score (age < 16 years) =< 40%Xx_NEWLINE_xXPatients must have a performance status corresponding to Karnofsky or Lansky greater than or equal to 50%; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky score >= 70% (>= 16 years) or Lansky score >= 50 (< 16 years)Xx_NEWLINE_xXAdequate performance status is defined as Karnofsky score >= 70% (>= 16 years of age) or Lansky score >= 50 (pediatrics)Xx_NEWLINE_xXLansky/Karnofsky performance status score of 50-100Xx_NEWLINE_xXPRIOR TO CELL PROCUREMENT: Karnofsky or Lansky score of > 60% (Karnofsky for ? 16 years old and Lansky for < 16 years old)Xx_NEWLINE_xXPRIOR TO LYMPHODEPLETION: Karnofsky or Lansky score of > 60% (Karnofsky for pediatric patients ? 16 years old and Lansky for < 16 years old)Xx_NEWLINE_xXPRIOR TO INFUSION OF ATLCAR.CD30 CELLS: Karnofsky or Lansky score of > 60% (Karnofsky for ? 16 years old and Lansky for < 16 years old)Xx_NEWLINE_xXPatients must have a performance status corresponding to Karnofsky or Lansky greater than or equal to 50%; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXAge 0 to 70 years of age with Karnofsky score >= 70% (>= 16 years) or Lansky score >= 50 (< 16 years)Xx_NEWLINE_xXKarnofsky Performance Score (KPS) >= 50% for patients >= 10 years of age; Lansky score of >= 50 for children < 10 years of ageXx_NEWLINE_xXKarnofsky performance status >= 50% for patients > 16 years of age, or Lansky performance status >= 50% for patients =< 16 years of age.Xx_NEWLINE_xXLansky/Karnofsky performance scale > 60%Xx_NEWLINE_xXLansky or Karnofsky ?50Xx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; Note: neurologic deficits in patients with CNS tumors must have been stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPerformance status defined by Karnofsky or Lansky >= 60 (except for patients with posterior fossa syndrome); use Karnofsky for patients >= 16 years and Lansky for patients < 16 years; note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered to be ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPerformance status:\r\n* Lansky >= 50 for individuals 18 months- =< 16 years old; Karnofsky > 50% for individuals 17-21 years oldXx_NEWLINE_xXPatient must have Karnofsky >= 60% for patients > 10 years of age; Lansky Play Scale >= 60 for children =< 10 years of ageXx_NEWLINE_xXPatients must have a performance status of 0, 1 or 2; use Karnofsky >= 60 for patients > 16 years of age and Lansky >= 60 for patients =< 16 years of ageXx_NEWLINE_xXEastern Cooperative Oncology Group (ECOG) score of =< 2 or Karnofsky/Lansky score >= 50%Xx_NEWLINE_xXLansky play score greater than or equal to 50% or Karnofsky Performance Status score greater than or equal to 50%. Use Karnofsky for participants greater than or equal to 16 years of age and Lansky for participants less than 16 years of age.Xx_NEWLINE_xXAt the time of study enrollment patients must have a Karnofsky greater than or equal to 50% for patients > 16 years of age and Lansky greater than or equal to 50 for patients less than or equal to 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPerformance status: Karnofsky >= 50 for patients > 16 years of age; Lansky >= 50 for patients =< 16 years of ageXx_NEWLINE_xXKarnofsky >= 60% for subjects > 16 years of age and Lansky >= 50 for subjects =< 16 years of age; note: subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky performance status >= 50 for patients >= 16 years of age and a Lansky performance status >= 50 for patients aged < 16 yearsXx_NEWLINE_xXPROCUREMENT: Karnofsky score ? 50%Xx_NEWLINE_xXTREATMENT: Karnofsky score ? 50%Xx_NEWLINE_xXPatients must have a Lansky Play Scale of 60% (< 16 years [yrs] old), Karnofsky score 60% (> 16 yrs old), or Eastern Cooperative Oncology Group (ECOG) score of < or equal to 2 and a life expectancy of 2 monthsXx_NEWLINE_xXKarnofsky performance status of >= 60% or, if less than 16 years of age Lansky play score of >= 60Xx_NEWLINE_xXPatients must have a performance status of >= 70; (Karnofsky if > 16 years and Lansky if =< 16 years of age)Xx_NEWLINE_xXKarnofsky ? 50% for patients > 16 years of age and Lansky ? 50 for patients ? 16 years of age.Xx_NEWLINE_xXPerformance level: Karnofsky > or equal to 50% for patients > 10 years of age or Lansky > or equal to 50 for patients < 10 years of age; Note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPatient must have a Lansky performance status score of >= 50; Note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXTREATMENT: Patients with a Karnofsky score of ? 50Xx_NEWLINE_xXLansky score of 50 or greater if =<16 years of age or a Karnofsky score of 50 or greater if > 16 years of age (NOTE: patients who are unable to walk because of paralysis, but who are in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score)Xx_NEWLINE_xXKarnofsky/Lansky score >= 60%Xx_NEWLINE_xXPatients must have a performance status of 0, 1 or 2 (Appendix I). Patients who are unable to walk because of paralysis or tumor pain, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXLansky score <50%Xx_NEWLINE_xXKarnofsky score (KS) >= 50Xx_NEWLINE_xXPerformance score of at least 70% by Karnofsky or 0 to 1 by Eastern Cooperative Oncology Group (ECOG) (age >= 12 years), or Lansky Play-performance scale of at least 70% or greater (age < 12 years)Xx_NEWLINE_xXKarnofsky or Lansky score of > 60%Xx_NEWLINE_xXKarnofsky or Lansky performance status of >= 50%Xx_NEWLINE_xXKarnofsky or Lansky (age-dependent) performance score >= 50Xx_NEWLINE_xXPatients must have a performance status of >= 70; (Karnofsky if > 16 years and Lansky if =< 16 years of ageXx_NEWLINE_xXAdequate Karnofsky Performance score or Lansky Play-Performance scaleXx_NEWLINE_xXPatients with a Karnofsky/Lansky score of >= 50Xx_NEWLINE_xXLansky performance status of >= 60% for participants 16 years old or youngerXx_NEWLINE_xXThe patient must be in adequate general condition for study, with Lansky or Karnofsky performance score of >= 50 at study entry; Lansky performance scale will be used for patients =< 16 years of ageXx_NEWLINE_xXKarnofsky performance status (KPS) or Lansky score > 50Xx_NEWLINE_xXKarnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within two weeks of enrollment must be >= 60; patients who are unable to walk because of neurologic deficits, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPatients must have a Lansky performance status of >= 30 for children =< 10 years of age or a Karnofsky performance status of > 30 for children > 10 years of ageXx_NEWLINE_xXKarnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) >= 50 assessed within 2 weeks prior to registrationXx_NEWLINE_xXFor subjects < 17 years of age, Modified Lansky Play-Performance Score of >= 70%; for subjects 17 and older, Karnofsky score of >= 70%Xx_NEWLINE_xXHave a Karnofsky performance status greater than or equal to 50 for patients aged 16 years or older and a Lansky performance status greater than or equal to 50 for patients less than 16 years oldXx_NEWLINE_xXLansky/Karnofsky scores >= 60Xx_NEWLINE_xXKarnofsky or Lansky score of > 60%Xx_NEWLINE_xXLansky or Karnofsky score < 50%Xx_NEWLINE_xXPatients must have a performance status of >= 70; (Karnofsky if > 16 years and Lansky if < 16 years of age)Xx_NEWLINE_xXKarnofsky/Lansky score >= 60%Xx_NEWLINE_xXKarnofsky score < 50% for adult patientsXx_NEWLINE_xXLansky play-performance score < 40 for pediatric patientsXx_NEWLINE_xXLansky/Karnofsky >= 50 (Lansky for subjects 7 - 15 years; Karnofsky for subjects 16 - 30 years); subjects who are unable to walk because of paralysis, but who are up in a wheelchair will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky/Lansky score of >= 50Xx_NEWLINE_xXKarnofsky/Lansky score of >= 50Xx_NEWLINE_xXPatients =< 50 must have performance status score: Karnofsky (for adults) >= 70 or Eastern Cooperative Oncology Group (ECOG) 0-1; Lansky (for children) score >= 50Xx_NEWLINE_xXPerformance status score: Karnofsky (for adults) >= 60 or ECOG 0-2; Lansky (for children) score >= 50Xx_NEWLINE_xXAdequate performance status; Lansky score >= 60% for children < 16 years of age, or Karnofsky score >= 60% for those > 16 years of ageXx_NEWLINE_xXPerformance status Lansky for children =< 16 years equal to at least 60, or greater Karnofsky status for those > 16 years of age equal to at least 70 or greaterXx_NEWLINE_xXPerformance status: Karnofsky >= 80% (subjects >= 16 years of age); Lansky >= 80% (for subjects 10-15 years of age)Xx_NEWLINE_xXLansky play score >= 50Xx_NEWLINE_xXRecipients must have a Karnofsky score (adults) >= 80 % or Lansky score >= 50% (pediatrics)Xx_NEWLINE_xXAdequate performance status is defined as Karnofsky score >= 60% (> 16 years of age) or Lansky score >= 50 (pediatrics)Xx_NEWLINE_xXPerformance level: Lansky ? 50% for patients ? 16 years of age and Karnofsky ? 50% for patients > 16 years of age.Xx_NEWLINE_xXPerformance level: Performance score ?50%. Karnofsky (for participants >16 years of age) or Lansky (for participants ?16 years of age)Xx_NEWLINE_xXPerformance status greater than or equal to (>=) 70 by Lansky scale (for participants less than [<] 16 years of age) or Karnofsky scale (for participants [>=] 16 years of age)Xx_NEWLINE_xXKarnofsky >= 80%, Lansky play score >= 70Xx_NEWLINE_xXPatients must have a performance status of >= 50 by Lansky or Karnofsky, corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1, or 2. Use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age. Patients who are unable to walk because of paralysis, but are up in a wheelchair will be considered ambulatory for the purposes of assessing the performance scoreXx_NEWLINE_xXPatients must have a Lansky (?16 years) or Karnofsky (> 16 years) score of at least 50Xx_NEWLINE_xXLansky (=< 10 years) or Karnofsky (> 10 years) score of at least 50Xx_NEWLINE_xXKarnofsky ? 60 for subjects > 16 years of age and Lansky ? 50 for subjects ? 16 years of age \r\n* Note: subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPRE-REGISTRATION: Performance level as measured by Karnofsky >= 60% for patients > 16 years of age or Lansky >= 60% for patients =< 16 years of age.Xx_NEWLINE_xXENROLLMENT: Performance level as measured by Karnofsky >= 60% for patients > 16 years of age or Lansky >= 60% for patients =< 16 years of age.Xx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; Note: Neurologic deficits in patients with CNS tumors must have been stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within two weeks of enrollment must be >= 60; patients who are unable to walk because of neurologic deficits, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50 for patients >= 16 years of age, and Lansky >= 50 for patients < 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score; patients with pre-existing neurological deficits need to be stable prior to surgery or lumbar puncture (LP) as determined by the investigatorXx_NEWLINE_xXKarnofsky (those 16 years old or older) or Lansky (those younger than 16 years) performance score of at least 50Xx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1 or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXSubject's Karnofsky performance status (KPS) must be >= 50% (Eastern Cooperative Oncology Group [ECOG] performance score < 3); the Lansky scale will be used for subjects less than 16 years of age and must be >= 50%Xx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1, or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPerformance status: Karnofsky >= 50% for patients > 16 years of age and Lansky >= 50% for patients =< 16 years of age; subjects who are wheelchair bound because of paralysis will be considered “ambulatory” when they are up in their wheelchair; subjects have to be able to travel to the NIH for evaluationsXx_NEWLINE_xXPatients must have a Lansky or Karnofsky performance status score of >= 70; Karnofsky system will be used for patients > 16 years of age and Lansky system for patients < 16 years of ageXx_NEWLINE_xXKarnofsky score >= 80% (adults), Lansky score >= 50% (pediatrics)Xx_NEWLINE_xXPatients must meet one of the following performance scores:\r\n* Eastern Cooperative Oncology Group (ECOG) performance status scores of 0, 1, or 2; \r\n* Karnofsky score of >= 60 for patients > 16 years of age; or\r\n* Lansky score of >= 60 for patients =< 16 years of ageXx_NEWLINE_xXPatients must have a performance status corresponding to an Eastern Cooperative Oncology Group (ECOG) scores of 0, 1 or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age; Note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPatients must have a Karnofsky performance score of 50% or greaterXx_NEWLINE_xXPatients must have a Karnofsky performance level of >= 30 for patients > 16 years of age or a Lansky performance scale of >= 30 for patients =< 16 years of age and life expectancy > 8 weeksXx_NEWLINE_xXLansky (=< 16 years) or Karnofsky (> 16 years) score of at least 50Xx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1, or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXPerformance status - Karnofsky >= 60 (16 years and older) or Lansky >= 50 (less than 16 years of age)Xx_NEWLINE_xXPatients must have a Lansky or Karnofsky performance status score of >= 50, corresponding to Eastern Cooperative Oncology Group (ECOG) categories 0, 1 or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; Note: neurologic deficits in patients with CNS tumors must have been relatively stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXECOG 0, 1 or 2, or for children =< 10 years of age, Lansky >= 60Xx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1 or 2; use Lansky for patients =< 16 years of ageXx_NEWLINE_xXDONOR: Donors in good general health, with a Karnofsky or Lansky play performance score > 90%Xx_NEWLINE_xXKarnofsky/Lansky score of 60% or greaterXx_NEWLINE_xXPatient with a Karnofsky performance score < 50% or Lansky score < 50%Xx_NEWLINE_xXKarnofsky >= 60% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; Note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXClinical performance status: patients > 10 years of age: Karnofsky >= 50%; patients =< 10 years of age: Lansky scale >= 50%; subjects who are unable to walk because of paralysis, but who are upright in a wheelchair will be considered ambulatory for the purpose of calculating the performance scoreXx_NEWLINE_xXPatients should have a Karnofsky/Lansky score of greater than or equal to 60; patients who require special assistance due to tumor-related paralysis, but who are out of bed during the day will be considered ambulatory for the purpose of calculating the performance score; patients must be able to communicate any symptomsXx_NEWLINE_xXPatients must have a Lansky or Karnofsky performance status score of >= 50%, corresponding to Eastern Cooperative Oncology Group (ECOG) categories of 0, 1, or 2 (use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age)Xx_NEWLINE_xXPerformance level: Karnofsky >= 50 for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age); Note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky/Lansky score of >= 50Xx_NEWLINE_xXKarnofsky/Lansky score of >= 50Xx_NEWLINE_xXKarnofsky/Lansky score of > 60%Xx_NEWLINE_xXIf <12 years of age: Lanksy Performance Status >50%Xx_NEWLINE_xXIf ?12 years of age: Karnofsky Performance Status >50%Xx_NEWLINE_xXSubject has a Karnofsky score of ? 50% (subjects ? 16 years of age) or a Lansky score ? 50% (subjects < 16 years of age).Xx_NEWLINE_xXLansky/Karnofsky score > 50Xx_NEWLINE_xXKarnofsky (age ? 16 years) or Lansky (age < 16 years) performance status ? 50 at screeningXx_NEWLINE_xXLansky score >50% for participants <16 years old.Xx_NEWLINE_xXKarnofsky (age ? 16 years) or Lansky (age < 16 years) performance status ? 50 at screening.Xx_NEWLINE_xXLansky Performance Status (participants less than [<] 16 years old) or Karnofsky Performance Status (participants greater than or equal to [>=] 16 years old) >=50Xx_NEWLINE_xXHave an ECOG performance status of 0-2 for ? 16 years of age and a Lansky performance status of 70-100 for < 16 years of ageXx_NEWLINE_xXKarnofsky or Lansky ? 50Xx_NEWLINE_xXAdequate Karnofsky Performance score or Lansky Play-Performance scaleXx_NEWLINE_xXKarnofsky score < 60 or Lansky score < 50Xx_NEWLINE_xXPerformance Status • Karnofsky > 50 % for patients >16 years of age or Lansky > 50 for patients < 16 years of age. Patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score.Xx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1 or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXKarnofsky/Lansky score >= 50%Xx_NEWLINE_xXKarnofsky/Lansky score >= 50%Xx_NEWLINE_xXKarnofsky or Lansky score of > 60%Xx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores 0, 1, or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXPatients must have Karnofsky performance score (for patients > 16 years of age) or Lansky performance score (for patients =< 16 years of age) >= 50% assessed within two weeks of study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPerformance status: Karnofsky or Lansky score ? 60% (Appendix A)Xx_NEWLINE_xXPerformance status: Lansky >= 50 for patients who are =< 16 years old and Karnofsky >= 50% for patients who are > 16 years oldXx_NEWLINE_xXLansky (age < 16 years at the time of assent/consent) or Karnofsky (age ? 16 years at the time of assent/consent) performance status ? 80 at screeningXx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1 or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXLansky score < 60%Xx_NEWLINE_xXKarnofsky or Lansky performance status (PS): performance status of >= 50 assessed within two weeks prior to registration; neurological deficits in patients must have been relatively stable for a minimum of 1 week prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within 14 days of enrollment must be >= 50Xx_NEWLINE_xXKarnofsky score >= 50 for patients >= 16 years of age and Lansky score >= 50 for patients =< 15 years of age; patients who are unable to walk because of paralysis but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky performance status (KPS) must be >= 70 for patients >= 16 years of age and Lansky performance status must be >= 70 for patients < 16 years of ageXx_NEWLINE_xXKarnofsky >= 50%; Note: subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXAT THE TIME OF INFUSION: Karnofsky or Lansky score of ? 50%Xx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50% for patients =< 16 years of age; neurologic deficits in patients with central nervous system (CNS) tumors must have been relatively stable for a minimum of 7 days; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXLansky (for participants 10 years of age or younger) or Karnofsky (for participants older than 10 years) performance score greater than 50Xx_NEWLINE_xXPatients ? 16 years oldXx_NEWLINE_xXKarnofsky performance scale (KPS for >= 16 years [yrs] of age) or Lansky performance score (LPS for < 16 years of age) >= 60 assessed within two weeks prior to registrationXx_NEWLINE_xXPerformance status: Karnofsky or Lansky scores ? 50 for subjects > 16 years old or ? 16 years old, respectively.Xx_NEWLINE_xXKarnofsky performance score ?50 for participants>16 year of age and Lansky play score ?50 for participants ?16 years of age. Neurologic deficits in participants with CNS tumors must have been relatively stable for at least 7 days prior to study enrollment. Participants who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXMust have a Lansky or Karnofsky performance status of >= 50; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXLansky (< 16 years old) >= 60Xx_NEWLINE_xXKarnofsky score >= 70 or Lansky score >= 70Xx_NEWLINE_xXPerformance score >= 50 (Lansky for research participants =< 16 years and Karnofsky for those > 16 years)Xx_NEWLINE_xXKarnofsky or Lansky performance score of greater than or equal to 50Xx_NEWLINE_xXPatients must have a Lansky or Karnofsky performance status score of >= 60%; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXPerformance status: Lansky >= 50 for individuals 18 months to < 10 years old; Karnofsky > 50% for individuals 10-21 years oldXx_NEWLINE_xXPerformance score of >= 60 by Karnofsky or performance score (PS) 0 to 2 (Eastern Cooperative Oncology Group [ECOG]) (age > 12 years), or Lansky play-performance scale >= 60 or greater (age < 12 years)Xx_NEWLINE_xXLansky/Karnofsky performance status score of 40-100Xx_NEWLINE_xXLansky play score >= 60 (< 16 years) or Karnofsky (16 years or older) performance score of >= 60%Xx_NEWLINE_xXKarnofsky score > 50%Xx_NEWLINE_xXKarnofsky scores < 60 or Lansky Score < 50Xx_NEWLINE_xXKarnofsky performance scale >= 12 years old (y/o) or Lansky performance score for patients < 12 y/o must be >= 50 assessed within two weeks prior to enrollmentXx_NEWLINE_xXPerformance Status: Eastern Cooperative Oncology Group (ECOG) score ? 3 (age ?16) or Lansky Performance Score (LPS) ?40% (age<16). If enrolled with primary CNS tumor to be assessed by RANO, Karnofsky Performance Status (KPS) (age ?16) or LPS (age<16) ? 50%Xx_NEWLINE_xXAge ?18 years (non-ESFT candidates) ECOG performance status (PS) 0-1. Pediatric patients with Lansky or Karnofsky Performance Status Scale ? of 50%.Xx_NEWLINE_xXEastern Cooperative Oncology Group (ECOG) performance status =< 2 for adults, Karnofsky performance status >= 50% for pediatric patients > 10 years of age, and Lansky performance status >= 50 for pediatric patients =< 10 years of ageXx_NEWLINE_xXLansky performance score >= 50% for patients =< 16 years of age, or Zubrod performance status score of 0-2 for patients > 16 years of ageXx_NEWLINE_xXPatients with a Karnofsky/Lansky score >= 50Xx_NEWLINE_xXKarnofsky performance score < 60 Lansky performance score < 60Xx_NEWLINE_xXLansky or Karnofsky scale >50Xx_NEWLINE_xXPerformance Score: Karnofsky ?60% if >10y/o, Lansky ?60 if ?10y/oXx_NEWLINE_xXKarnofsky performance score (KPS) or Lansky score >= 40Xx_NEWLINE_xXAdequate performance status as defined by Lansky Score >= 30 (except for Posterior Fossa Syndrome)Xx_NEWLINE_xXPerformance score of at least 60% by Karnofsky or performance status (PS) less than 3 (Eastern Cooperative Oncology Group [ECOG]) (age greater than or equal to 12 years), or Lansky play-performance scale of at least 60% or greater (age < 12 years)Xx_NEWLINE_xXPatients should have a life expectancy of at least 12 months and a Karnofsky or Lansky performance score of >= 50; patients who are wheelchair bound because of paralysis should be considered “ambulatory” when they are up in their wheel chairXx_NEWLINE_xXKarnofsky score < 50%\r\n* Pediatric criteria\r\n** Lansky play-performance score < 40Xx_NEWLINE_xXKarnofsky score less than 60; pediatric criteria: Lansky Play-Performance Score < 40Xx_NEWLINE_xXLansky >= 50 for patients =< 16 years old; Karnofsky >= 50 for patients > 16 years oldXx_NEWLINE_xXPatients must have a Lansky (< 16 years) or Karnofsky (> 16 years) score of at least 50Xx_NEWLINE_xXKarnofsky or Lansky performance score is >= 60%; the Lansky performance score should be used for participants < 16 years and the Karnofsky performance score for participants >= 16 yearsXx_NEWLINE_xXQuality of life must be 3 by Lansky and 50% by KarnofskyXx_NEWLINE_xXKarnofsky > 50% for patients > 16 years of age and Lansky > 50% for patients ? 16 years of age.Xx_NEWLINE_xXECOG 0-2 or Karnofsky ? 50% for patients > 16 years of age; Lansky ? 50% for patients ?16 years of age.Xx_NEWLINE_xXKarnofsky Performance Score ?50%Xx_NEWLINE_xXThe presence of TAM high risk features at baseline (or screening if baseline visit is skipped): Patients ? 16 years must have a Lansky score of ? 70 and patients > 16 must have Karnofsky score ? 70% and/or proteinuria (> 30 mg/dL) measured in two urine spot analyses.Xx_NEWLINE_xXSubjects ? 16 years: Karnofsky score ? 70%.Xx_NEWLINE_xXSubjects < 16 years: Lansky score ? 70%.Xx_NEWLINE_xXKarnofsky/Lansky performance scale\r\n* ARM A: > 60%\r\n* ARM B: No limitationXx_NEWLINE_xXSubjects ? 16 years of age: Karnofsky ? 60% (Appendix A)Xx_NEWLINE_xXSubjects < 16 years of age: Lansky scale ? 60% (Appendix A)Xx_NEWLINE_xXKarnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within two weeks of registration must be >= 60Xx_NEWLINE_xXPerformance status: Eastern Cooperative Oncology Group (ECOG) 0, 1 or 2, or for children =< 10 years of age, Lansky >= 60; note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPerformance status: Karnofsky (for participants >/= 16 years of age) or Lansky (for participants < 16 years of age) score of >/= 60Xx_NEWLINE_xXKarnofsky performance status > 70% for patients 16 years and older and Lansky performance status > 50% for patients under 16 years of ageXx_NEWLINE_xXAdequate Karnofsky/Lansky Performance scoreXx_NEWLINE_xXRECURRENT/ PROGRESSIVE DIPG (STRATUM 1): Karnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within 7 days of enrollment must be >= 50%; patients who are unable to walk because of neurologic deficits, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXNON-PROGRESSED DIPG (STRATUM 2): Karnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within 7 days of enrollment must be >= 50%; patients who are unable to walk because of neurologic deficits, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky performance status > 80% for ages 16 years and older or Lansky play score > 50 for < 16 yearsXx_NEWLINE_xXPatient has a minimum Karnofsky/Lansky Performance Level of at least 30 at the time of study entry.Xx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1 or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXPerformance status: Lansky >= 50 for patients who are =< 16 years old and Karnofsky >= 50% for patients who are > 16 years oldXx_NEWLINE_xXKarnofsky or Lansky performance score of greater than or equal to 50Xx_NEWLINE_xXKarnofsky or Lansky performance score is >= 60%; the Lansky performance score should be used for participants < 16 years and the Karnofsky performance score for participants >= 16 yearsXx_NEWLINE_xXKarnofsky Performance Status (KPS) or Lansky Score ? 50Xx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; note: neurologic deficits in patients with central nervous system (CNS) tumors must have been relatively stable for a minimum of 1 week prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPerformance score of at least 80% by Karnofsky or performance status (PS) < 3 (Eastern Cooperative Oncology Group [ECOG]) (age >= 12 years), or Lansky Play-Performance scale of at least 60% or greater (age < 12 years)Xx_NEWLINE_xXKarnofsky > 50% for patients > 16 years of age and Lansky > 50% for patients less than or equal to 16 years of age. (See Appendix I for Performance Scales).Xx_NEWLINE_xXKarnofsky or Lansky performance score is >= 60%; the Lansky performance score should be used for participants < 16 years and the Karnofsky performance score for participants >= 16 yearsXx_NEWLINE_xXKarnofsky or Lansky (age-dependent) performance score >= 50Xx_NEWLINE_xXKarnofsky or Lansky performance score >= 50Xx_NEWLINE_xXPerformance Level: Karnofsky > 50% for pts > 12 years; Lansky > 50% for pts < 12 years of age.Xx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1 or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXKarnofsky performance status score ? 50 for patients >16 years of ageXx_NEWLINE_xXLansky performance status score ? 50 for patients ? 16 years of ageXx_NEWLINE_xXPatients must have a life expectancy of at least 8 weeks and a Lansky (< 16 years age) or Karnofsky (> 16 years age) score of at least 50Xx_NEWLINE_xXPerformance score of >=50% according to the Karnofsky/Lansky performance status scale.Xx_NEWLINE_xXAge between 16Xx_NEWLINE_xXKarnofsky performance status >= 60% for patients > 16 years old (yo) and Lansky performance status >= 60% for patients =< 16 yoXx_NEWLINE_xXPerformance score of >=50% according to the Karnofsky/Lansky performance status scale (subjects with a performance status of <=50% can be enrolled if the subject's confinement to bed and inability to carry out activities is due solely to cancer-related pain, as assessed by the investigator).Xx_NEWLINE_xXPatients > 16 years of age must have a Karnofsky performance level of >= 70%, and children =< 16 years old must have a Lansky performance of >= 70%; patients who are wheelchair bound because of paralysis secondary to a plexiform neurofibroma should be considered ambulatory when they are up in their wheelchair; similarly, patients with limited mobility secondary to need for mechanical support (such as an airway PN requiring tracheostomy or continuous positive airway pressure [CPAP]) will also be considered ambulatory for the purpose of the studyXx_NEWLINE_xXEastern Cooperative Oncology Group (ECOG) performance status ? 3 for subjects aged > 16 years; Lansky score ? 20 for subjects from birth to 16 yearsXx_NEWLINE_xXParticipants less than or equal to 16 years of age must have performance status of Lansky greater than or equal to 50% and participants greater than 16 years of age must have performance status of Karnofsky greater than 50%.Xx_NEWLINE_xXKarnofsky or Lansky (age-dependent) performance score >= 50Xx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age or Lansky >= 50% for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPerformance score ? 60 from Lansky Play Performance Scale if ?16 yearsXx_NEWLINE_xXKarnofsky/Lansky score above 50%Xx_NEWLINE_xXAll patients must have a projected survival time of at least 12 weeks and a Karnofsky performance score: >60% (or Zubrod score of >2).Xx_NEWLINE_xXPerformance status: Karnofsky > 50% for >= 16 years of age; Lansky > 50% for children < 16 years of ageXx_NEWLINE_xXPerformance Status: Karnofsky >= 50% for > 10 years of age; Lansky >= 50% for children =< 10 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purposes of assessing performance scoreXx_NEWLINE_xXPerformance status: Karnofsky >= 50 for > 10 years of age; Lansky >= 50 for children =< 10 years of ageXx_NEWLINE_xXPerformance status: Karnofsky ? 60% for 12 to <18 years of age; Lansky play scale ? 60% for 1 to < 12 years of age.Xx_NEWLINE_xXKarnofsky performance status less than 60% or Lansky less than 40% for patients younger than 16 years oldXx_NEWLINE_xXPerformance status - Karnofsky 50-100% (> 16 years of age)Xx_NEWLINE_xXPerformance status - Lansky 30-100% (? 16 years of age)Xx_NEWLINE_xXPatients must have a Lansky or Karnofsky performance scale score of >= 50% and patients must have a life expectancy of >= 2 monthsXx_NEWLINE_xXKarnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXKarnofsky Performance Status >= 50% for patients 16 years and older and Lansky Play Score >= 50 for patients under 16 years of ageXx_NEWLINE_xXPatient has Karnofsky score > 50 (ambulatory & capable of self-care)Xx_NEWLINE_xXPerformance status: Lansky >= 50 for patients who are =< 16 years old and Karnofsky >= 50% for patients who are > 16 years oldXx_NEWLINE_xXKarnofsky performance status >= 50% for patients >= 16 years of age and Lansky >= 50% for patients < 16 years of ageXx_NEWLINE_xXKarnofsky performance score >= 50%Xx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1 or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1, or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXLansky or Karnofsky performance >= 40%Xx_NEWLINE_xXKarnofsky performance score or Lansky Play-Performance Scale score < 80Xx_NEWLINE_xXHas a KPS score of >= 50Xx_NEWLINE_xXPerformance status must be > 60 from Lansky (age 1 to 16) or Karnofsky (age > 16)Xx_NEWLINE_xXLansky/Karnofsky score < 60Xx_NEWLINE_xXKarnofsky >= 50% for patients > 10 years of age and Lansky >= 50 for patients =< 10 years of ageXx_NEWLINE_xXAYA is able to participate in sessions as evaluated by the Karnofsky/Lansky score of 50% or greaterXx_NEWLINE_xXPatient has Karnofsky score >= 50 or World Health Organization (WHO)/Eastern Cooperative Oncology Group (ECOG) =< 2 if >= 16 years of ageXx_NEWLINE_xXLansky score >= 50 for patients age < 16Xx_NEWLINE_xXECOG score of 0,1,or 2 OR Karnofsky score of 50 or higherXx_NEWLINE_xXKarnofsky/Lansky score of >= 50Xx_NEWLINE_xXELIGIBILITY CRITERIA FOR ENROLLMENT ONTO APEC1621SC: Karnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age); Note: neurologic deficits in patients with CNS tumors must have been stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXGENERAL INCLUSION CRITERIA FOR SUBPROTOCOLS: Karnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age); Note: neurologic deficits in patients with CNS tumors must have been stable for at least 7 days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1, or 2; use Lansky for patients =< 16 years of ageXx_NEWLINE_xXPatients must have a Lansky or Karnofsky Performance Scale score of > 50% and patients must have a life expectancy of ? 2 months.Xx_NEWLINE_xXPerformance status by Karnofsky of >= 70% or Lansky > 70% for patients < 16 years of ageXx_NEWLINE_xXKarnofsky or Lansky score of > 60%Xx_NEWLINE_xXKarnofsky score < 60 for adult patientsXx_NEWLINE_xXLansky-play performance score < 50 for pediatric patientsXx_NEWLINE_xXPatients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0 or 1 (>= 70% for Karnofsky/Lansky); use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of ageXx_NEWLINE_xXScore at least a 5 on the Contemplation LadderXx_NEWLINE_xXLansky score < 60%Xx_NEWLINE_xXLansky score < 60%Xx_NEWLINE_xXPerformance status: Karnofsky/Lansky score > 60%.Xx_NEWLINE_xXECOG 0-1, or for children ?10 years of age, Lansky > 60Xx_NEWLINE_xXPatients with a Karnofsky/Lansky score of >= 50Xx_NEWLINE_xXLansky score ? 50 orXx_NEWLINE_xXKarnofsky score > 50 orXx_NEWLINE_xXHas a Lansky Play Performance score ?60 (participants ?16 years of age) or a Karnofsky score ?60 (participants >16 years of age)Xx_NEWLINE_xXPatients with Lansky (age < 16 years) or Karnofsky (age >= 16 years) score < 50 will be excludedXx_NEWLINE_xXKarnofsky performance status >= 50 for patients >= 12 years of age; for children < 12 years of age, the Lansky play scale >= 50% can be substitutedXx_NEWLINE_xXKarnofsky >= 70 for patients >= 16 years of age, and Lansky >= 70 for patients < 16 years of ageXx_NEWLINE_xXKarnofsky performance of >= 50 corresponding to Eastern Cooperative Oncology Group (ECOG) categories 0, 1, or 2; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPHASE I: Performance status >= 60 on Karnofsky scale for patients > 16 years of age and > 60 on Lansky scale for patients < 16 years of ageXx_NEWLINE_xXEXPANSION COHORT: Performance status of >= 60 on Karnofsky scale for patients > 16 years of age and > 60 on Lansky scale for patients =< 16 years of ageXx_NEWLINE_xXPatient must have a Lansky or Karnofsky performance of > 40% corresponding to Eastern Cooperative Oncology Group (ECOG) categories 0, 1, or 2; Karnofsky will be used for patients > 16 years of age and Lansky for patients < 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance scoreXx_NEWLINE_xXPatients must have a performance status of >= 50 using the Karnofsky scale for patients > 16 years of age and the Lansky scale for patients =< 16 years of ageXx_NEWLINE_xXKarnofsky (patients ? 16 years)/Lansky (patients < 16 years) index ? 70.Xx_NEWLINE_xX