Adequate liver function, including:Xx_NEWLINE_xXPatients must have adequate renal function with serum creatinine level =< IULN within 21 days prior to registrationXx_NEWLINE_xXAdequate hematologic, hepatic, and renal functionXx_NEWLINE_xXAdequate hematological, renal, metabolic and hepatic function within 7-10 days prior to randomizationXx_NEWLINE_xXSubjects must have adequate renal function defined as a serum creatinine based on age/genderXx_NEWLINE_xXSubject must have adequate hematologic, renal and hepatic function.Xx_NEWLINE_xXAdequate hepatic and renal functionXx_NEWLINE_xXAdequate hematologic functionXx_NEWLINE_xXAdequate organ function as demonstrated by hematological, renal, hepatic laboratory assessments;Xx_NEWLINE_xXParticipants must have adequate hematologic, renal and hepatic function.Xx_NEWLINE_xXMust have adequate hepatic, renal, cardiac and hematopoietic functionXx_NEWLINE_xXHepatic function as follows:Xx_NEWLINE_xXInsufficient hepatic and renal function.Xx_NEWLINE_xXAdequate hepatic function as evidenced by:Xx_NEWLINE_xXAdequate renal function as evidenced by a serum/plasma creatinine < 1.5 x ULNXx_NEWLINE_xXThe following criteria for evidence of adequate hepatic function performed within 2 weeks prior to study entry must be met:Xx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXAdequate blood coagulation functionXx_NEWLINE_xXAdequate liver functionXx_NEWLINE_xXAdequate performance status and hematological, liver, and kidney functionXx_NEWLINE_xXAdequate hematologic functionXx_NEWLINE_xXAdequate hepatic functionXx_NEWLINE_xXAdequate hepatic, renal, cardiac, and hematologic functionXx_NEWLINE_xXOut of range laboratory values for measures of hepatic and renal function, electrolytes and blood countsXx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXAdequate coagulation functionXx_NEWLINE_xXAdequate hepatic functionXx_NEWLINE_xXAcceptable hematological function:Xx_NEWLINE_xXAdequate physical function as measured by all of the following:Xx_NEWLINE_xXAdequate renal function:Xx_NEWLINE_xXAdequate hepatic function:Xx_NEWLINE_xXAdequate cardiovascular, hematological, liver and renal functionXx_NEWLINE_xXPoor hematologic, renal, or hepatic functionXx_NEWLINE_xXAdequate liver function:Xx_NEWLINE_xXAcceptable liver and renal functionXx_NEWLINE_xXAdequate hematologic, renal, and hepatic parametersXx_NEWLINE_xXPatients must have adequate hepatic function as evidenced by:Xx_NEWLINE_xXHepatic: Adequate liver function is defined as:Xx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXAdequate liver functionXx_NEWLINE_xXAcceptable liver, renal, hematologic and coagulation functionXx_NEWLINE_xXAdequate hematologic, renal, and hepatic functionXx_NEWLINE_xXAdequate hematologic, hepatic, and renal function.Xx_NEWLINE_xXThe following criteria for evidence of adequate hepatic function performed within 28 days prior to randomization must be met:Xx_NEWLINE_xXAdequate hepatic functionXx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXAdequate liver function defined by:Xx_NEWLINE_xXadequate hematologic, renal and hepatic functionXx_NEWLINE_xXAdequate liver and renal functionXx_NEWLINE_xXInadequate hematologic function as evidenced by any of the following:Xx_NEWLINE_xXActive or severe hepatic or renal disease.Xx_NEWLINE_xXAdequate Renal & Liver Function.Xx_NEWLINE_xXAdequate hepatic function within 28 days prior to study registration defined as meeting all of the following criteria:Xx_NEWLINE_xXAdequate renal function within 28 days prior to study registration defined by either of the following criteria:Xx_NEWLINE_xXAdequate hematologic function within 28 days prior to study registration defined as meeting all of the following criteria:Xx_NEWLINE_xXAdequate hematologic, renal, and liver functionXx_NEWLINE_xXCombination Arm: adequate heart functionXx_NEWLINE_xXAdequate pulmonary and cardiac functionXx_NEWLINE_xXAdequate hepatic function.Xx_NEWLINE_xXAdequate renal function.Xx_NEWLINE_xXAdequate hepatic function, as follows:Xx_NEWLINE_xXHematological function:Xx_NEWLINE_xXHas adequate hematopoietic, coagulation, renal and hepatic function. Subject must remain eligible for continued treatment with tazemetostat according to the eligibility and treatment criteria from the antecedent study.Xx_NEWLINE_xXSubjects must have adequate liver function as defined by:Xx_NEWLINE_xXSubjects must have adequate renal functionXx_NEWLINE_xXPoor hematologic, renal, or hepatic functionXx_NEWLINE_xXAdequate renal and hepatic functionXx_NEWLINE_xXAcceptable hematologic, renal and liver function as follows:Xx_NEWLINE_xXHepatic and renal functionXx_NEWLINE_xXAdequate cardiac, hematological, liver and renal functionXx_NEWLINE_xXAdequate organ function: Patients should have adequate hepatic, renal, cardiac and pulmonary function to undergo reduced intensity HCT based upon local institutional guidelines, or at a minimum meet requirements noted in eligibility checklist Appendix A-VIII_1. However, significant hepatic and pulmonary dysfunction, if secondary to underlying LCH disease activity, will not exclude patients from protocol enrollment and should be discussed with the National PI Coordinator and the Coordinating Principal Investigator.Xx_NEWLINE_xXInadequate renal function as defined by serum creatinine > 3x normal for ageXx_NEWLINE_xXAdequate renal and hepatic function:Xx_NEWLINE_xXAdequate hematological function, defined as:Xx_NEWLINE_xXAdequate liver function, defined as:Xx_NEWLINE_xXAdequate renal function, defined as:Xx_NEWLINE_xXAdequate pulmonary function defined as no evidence of dyspnea at restXx_NEWLINE_xXAdequate renal and hepatic function, per laboratory reference range at screeningXx_NEWLINE_xXSubjects must have adequate hepatic, renal, and bone marrow function. There are no specific minimum criteria for enrollment; this will at the discretion of the treating physician, as any patient who would be considered for standard of care treatment with these drugs may be considered for this trialXx_NEWLINE_xXAdequate hematologic statusXx_NEWLINE_xXAdequate coagulation functionXx_NEWLINE_xXAdequate hepatic functionXx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXDemonstrate adequate hematological, renal, hepatic, and coagulation function;Xx_NEWLINE_xXMust have adequate coagulation, hematology, kidney, and liver function, per protocol.Xx_NEWLINE_xXAdequate hepatic profile.Xx_NEWLINE_xXAdequate renal function.Xx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXAdequate liver functionXx_NEWLINE_xXAdequate hematological functionXx_NEWLINE_xXAdequate hepatic profile:Xx_NEWLINE_xXAdequate renal function:Xx_NEWLINE_xXAdequate hematological, hepatic and renal function prior to first doseXx_NEWLINE_xXAdequate renal function including creatinine < 2 unless related to the diseaseXx_NEWLINE_xXInadequate hematologic, renal or hepatic function.Xx_NEWLINE_xXAdequate renal, hepatic, pulmonary and cardiac function defined as:Xx_NEWLINE_xXAdequate hepatic, renal, cardiac, and hematologic function.Xx_NEWLINE_xXAn eastern cooperative oncology group performance status (ECOG PS) of 0 to 1 at screening and adequate hematological, renal and hepatic function as defined by protocol specified criteria.Xx_NEWLINE_xXRenal function and Hepatic functionXx_NEWLINE_xXAdequate renal and hepatic function as defined:Xx_NEWLINE_xXSubject has adequate liver function defined as:Xx_NEWLINE_xXSubject has adequate pulmonary function defined as:Xx_NEWLINE_xXHave adequate hematologic function within 15 days prior to study treatment, defined as meeting all of the following criteria:Xx_NEWLINE_xXParticipants must have adequate renal function, defined as:Xx_NEWLINE_xXParticipants must have adequate liver function, defined as:Xx_NEWLINE_xXAdequate organ function, including renal and hepatic function based on the last assessment performed within the Screening Period Patients enrolled in the Dose Finding Portion of the Study:Xx_NEWLINE_xXAdequate liver function:Xx_NEWLINE_xXAdequate hematologic, renal and hepatic laboratory parametersXx_NEWLINE_xXMust have adequate hematologic, renal and hepatic function.Xx_NEWLINE_xXAdequate renal, hepatic, cardiac, and pulmonary function as evidenced by:Xx_NEWLINE_xXAdequate hematologic functionXx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXAdequate hepatic functionXx_NEWLINE_xXRenal Function as follows:Xx_NEWLINE_xXHepatic function, as follows:Xx_NEWLINE_xXDONOR: Cardiac, renal, pulmonary, and hepatic function within normal limitsXx_NEWLINE_xXAdequate hepatic function as defined as follows:Xx_NEWLINE_xXAdequate renal function defined as follows:Xx_NEWLINE_xXAdequate hepatic function defined as:Xx_NEWLINE_xXInadequate liver, renal function as defined below for both cohorts:Xx_NEWLINE_xXAdequate hematological, hepatic and renal functionXx_NEWLINE_xXAdequate hepatic and renal functions as defined by:Xx_NEWLINE_xXAdequate renal function, as indicated by creatinine =< 1.5 x ULNXx_NEWLINE_xXThe patient has adequate hepatic function per protocolXx_NEWLINE_xXDocumented hepatic insufficiency or renal failureXx_NEWLINE_xXAdequate liver function:Xx_NEWLINE_xXAdequate renal function:Xx_NEWLINE_xXAdequate organ function as per Hematologic, Hepatic, Renal and Cardiac Laboratory ValuesXx_NEWLINE_xXAdequate hepatic and renal functions as defined by:Xx_NEWLINE_xXAdequate renal function with creatinine (Cr) =< 2.5 mg/dLXx_NEWLINE_xXHematological function:Xx_NEWLINE_xXRenal function:Xx_NEWLINE_xXHepatic function:Xx_NEWLINE_xXAdequate hematologic, hepatic, and renal functionXx_NEWLINE_xXAdequate renal and hepatic function:Xx_NEWLINE_xXAdequate renal function assessed by: serum creatinine ? 1.5 × ULNXx_NEWLINE_xXSubjects must have adequate hematologic, hepatic and renal function.Xx_NEWLINE_xXAdequate hepatic and renal functionXx_NEWLINE_xXAdequate renal function: creatinine ?1.5 x ULNXx_NEWLINE_xXImpaired renal functionXx_NEWLINE_xXReproductive function:Xx_NEWLINE_xXHepatic function, renal function, bone marrow function in defined lab-value-rangesXx_NEWLINE_xXAdequate baseline hematologic, renal, and hepatic functionXx_NEWLINE_xXHas adequate hematologic (bone marrow [BM] and coagulation factors), renal and hepatic function as defined by criteria below:Xx_NEWLINE_xXHematologic (BM Function):Xx_NEWLINE_xXRenal Function:Xx_NEWLINE_xXHepatic Function:Xx_NEWLINE_xXHave adequate renal function as defined by the following criterion:Xx_NEWLINE_xXHave adequate hepatic function as defined by the following criteria:Xx_NEWLINE_xXMust have adequate hepatic and kidney function.Xx_NEWLINE_xXAdequate hematological, renal, hepatic and coagulation function is required.Xx_NEWLINE_xXRenalXx_NEWLINE_xXHepaticXx_NEWLINE_xXAdequate renal and hepatic function:Xx_NEWLINE_xXAdequate hematopoietic capacity, hepatic and renal functionXx_NEWLINE_xXAdequate liver function as evidenced by:Xx_NEWLINE_xXAdequate renal function:Xx_NEWLINE_xXAdequate hepatic function:Xx_NEWLINE_xXAdequate Renal Function:Xx_NEWLINE_xXAdequate Liver Function:Xx_NEWLINE_xXEvidence of inadequate renal function (creatinine > 2 g/dL)Xx_NEWLINE_xXHas adequate hepatic function, defined as:Xx_NEWLINE_xXThe following criteria for evidence of adequate hepatic function performed within 4 weeks prior to study entry must be met:Xx_NEWLINE_xXRenal function: preservation of renal function, serum creatinine did NOT increase by more than 2 fold above the normal reference rangeXx_NEWLINE_xXRenal function criteria: preservation of renal function, serum creatinine did NOT increase by more than 2 fold above the normal reference rangeXx_NEWLINE_xXSubjects must have adequate liver function as defined by:Xx_NEWLINE_xXSubjects must have adequate renal function defined as: Serum creatinine based on age/gender.Xx_NEWLINE_xXAdequate hematologic function (unless abnormalities are related to NHL), defined as follows:Xx_NEWLINE_xXPatients are required to have adequate renal function as indicated by a serum creatinine =< 2.5 mg/dL; this value must be obtained within four weeks before protocol entryXx_NEWLINE_xXAdequate hematologic, hepatic, and renal functionXx_NEWLINE_xXAdequate hematological, hepatic, and renal function:Xx_NEWLINE_xXAcceptable renal functionXx_NEWLINE_xXAdequate baseline hematologic, renal, and hepatic functionXx_NEWLINE_xXPatient must have adequate renal function as defined by serum creatinine < -2.5 mg/dl obtained within 28 days prior to registrationXx_NEWLINE_xXRenal Function: Adequate renal function in the opinion of the Investigator with no clinically significant renal impairment or uncontrolled renal disease.Xx_NEWLINE_xXImmunological Function: Adequate immune system function in the opinion of the Investigator with no known immunodeficiency disease.Xx_NEWLINE_xXAdequate renal function, defined as:Xx_NEWLINE_xXAdequate liver function, defined as:Xx_NEWLINE_xXAcceptable renal functionXx_NEWLINE_xXAdequate hepatic function performed within 4 weeks prior to study entry must be met:Xx_NEWLINE_xXAdequate hematological, liver and kidney function.Xx_NEWLINE_xXSubject has adequate hematologic function and adequate hepatic function at screeningXx_NEWLINE_xXAdequate hematological, liver, and kidney functionXx_NEWLINE_xXAdequate liver and renal functionXx_NEWLINE_xXPatients must have adequate renal/hematologic function, as defined by creatinine clearance > 30ml/min and platelets>50,000.Xx_NEWLINE_xXAdequate liver and renal function and hematology laboratory valuesXx_NEWLINE_xXAdequate hematologic, coagulation (INR 2-3 max), hepatic and renal functionXx_NEWLINE_xXInadequate hematologic, coagulation (INR >3), hepatic, renal functionXx_NEWLINE_xXAdequate hematologic, renal and hepatic functionXx_NEWLINE_xXAdequate liver functionXx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXGood health with adequate hematologic, renal, hepatic, and cardiac function, as determined by the Investigator, based upon medical history, physical examination, and laboratory test results at the screening visit (Visit 1):Xx_NEWLINE_xXRenal and hepatic function values exceeding 2 times the upper normal valueXx_NEWLINE_xXHas protocol-defined adequate renal, hepatic and cardiac statusXx_NEWLINE_xXParticipant must have adequate hematologic, renal, and liver function laboratory values as described in the protocol.Xx_NEWLINE_xXThe patient has adequate pulmonary functionXx_NEWLINE_xXAdequate renal and hepatic function:Xx_NEWLINE_xXAdequate hepatic function within 48 hours prior to induction chemotherapyXx_NEWLINE_xXAdequate hepatic functionXx_NEWLINE_xXAdequate renal functionsXx_NEWLINE_xXAdequate renal and hepatic function (creatinine ? 1.5 x IULN, bilirubin within normal limits, AST and ALT ? 3.0 x IULN or 5 x IULN if know liver metastases)Xx_NEWLINE_xXAdequate hematopoietic, renal, and hepatic functions defined as:Xx_NEWLINE_xXPatients must have adequate renal function defined as age-adjusted serum creatinine =< 1.5 x normal for ageXx_NEWLINE_xXSubjects must have adequate renal, hepatic and bone marrow function based on screening laboratory assessments. Baseline hematologic studies and chemistry and coagulation profiles must meet the following criteria:Xx_NEWLINE_xXHave adequate hepatic functionXx_NEWLINE_xXHave adequate renal functionXx_NEWLINE_xXAdequate hepatic, renal, cardiac, and hematologic functionXx_NEWLINE_xXAcceptable renal functionXx_NEWLINE_xXAdequate liver and renal functionXx_NEWLINE_xXPatients with both hepatic and renal dysfunction will also be excludedXx_NEWLINE_xXAdequate bone marrow function (absolute neutrophil count > 1,500/mm3 and platelet count of > 100,000/mm3), adequate liver function [ALT and AST <3 x upper limit normal (ULN), alkaline phosphatase <2 x ULN, and total bilirubin <1.5 mg/dL], & adequate renal function (BUN and creatinine <1.5 x ULN)Xx_NEWLINE_xXAdequate hematological and biological function, confirmed by defined laboratory\n             valuesXx_NEWLINE_xXRenal function: CrCl < 15 ml/min.Xx_NEWLINE_xXAdequate renal function: serum creatinine =< 1.5 x ULNXx_NEWLINE_xXAdequate hepatic and renal function (these must be WNL or verified by study chair to be related to conditions not interfering with normal health status)Xx_NEWLINE_xXAdequate hematologic, renal, and hepatic function.Xx_NEWLINE_xXAdequate hematologic, hepatic, renal, and coagulation function.Xx_NEWLINE_xXHas adequate hematologic (bone marrow and coagulation factors), renal and hepatic function as defined by criteria below:Xx_NEWLINE_xXHematologic (BM Function):Xx_NEWLINE_xXHepatic Function:Xx_NEWLINE_xXAdequate kidney and hematologic function assessed from baseline laboratory dataXx_NEWLINE_xXParticipant must have adequate hematologic, renal, hepatic, and lung function.Xx_NEWLINE_xXAdequate baseline renal and hepatic functionXx_NEWLINE_xXInadequate hepatic functionXx_NEWLINE_xXInadequate renal functionXx_NEWLINE_xXSubject has adequate renal function, which is defined as:Xx_NEWLINE_xXSubjects must have adequate hematopoietic function as evidenced by:Xx_NEWLINE_xXSubjects must have adequate liver function, including all of the following:Xx_NEWLINE_xXAdequate hematologic, renal, and hepatic function (within 28 days of randomization).Xx_NEWLINE_xXAdequate hematological, renal, and liver functionXx_NEWLINE_xXAdequate haematological, hepatic and renal functions defined by the protocolXx_NEWLINE_xXAdequate hematologic, renal, and hepatic functionXx_NEWLINE_xXSubject must have adequate kidney and liver function as described in the protocolXx_NEWLINE_xXAdequate hematologic and renal function, based upon meeting protocol defined laboratory criteria within 7 days before randomization.Xx_NEWLINE_xXAdequate hematologic, renal, and hepatic functionXx_NEWLINE_xXRenal function defined as:Xx_NEWLINE_xXHave adequate hematologic function.Xx_NEWLINE_xXHave adequate coagulation function.Xx_NEWLINE_xXHave adequate hepatic function.Xx_NEWLINE_xXHave adequate renal function as defined by creatinine clearance >30 milliliters/minute.Xx_NEWLINE_xXAdequate hematological, liver, and renal functionXx_NEWLINE_xXAdequate renal function, defined as serum creatinine ?1.5x ULN or GFR >50 mL/minXx_NEWLINE_xXAdequate hematologic function:Xx_NEWLINE_xXAdequate hepatic and renal function defined as:Xx_NEWLINE_xXAdequate hematologic functionXx_NEWLINE_xXAdequate hepatic functionXx_NEWLINE_xXThe patient has adequate baseline organ function, including cardiac, renal, and hepatic function:Xx_NEWLINE_xXThe patient has adequate baseline organ function, including cardiac, renal, and hepatic function:Xx_NEWLINE_xXAcceptable liver and renal function:Xx_NEWLINE_xXHas protocol-defined adequate cardiac, renal and hepatic functionXx_NEWLINE_xXAdequate renal and hepatic function defined as:Xx_NEWLINE_xXAdequate hematologic, hepatic, and renal functionXx_NEWLINE_xXInadequate hematologic, hepatic, or renal functionXx_NEWLINE_xXSubjects who have adequate hematological, renal, hepatic and respiratory functions defined.Xx_NEWLINE_xXAdequate liver function:Xx_NEWLINE_xXAdequate blood clotting functionXx_NEWLINE_xXSubject must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 and must have a serum lactate dehydrogenase (LDH) ? 1.0 X upper limit of normal and adequate hematologic, hepatic, renal, and coagulation organ function- Other criteria may applyXx_NEWLINE_xXAdequate hematologic functionXx_NEWLINE_xXAdequate liver functionXx_NEWLINE_xXHas adequate hematologic (bone marrow [BM] and coagulation factors), renal and hepatic functionXx_NEWLINE_xXAdequate hepatic, and renal functionXx_NEWLINE_xXAdequate hematologic functionXx_NEWLINE_xXAdequate hematologic, renal, and hepatic function determined by laboratory blood and urine tests.Xx_NEWLINE_xXAdequate Blood, renal and hepatic function, as determined within 28 days from registration:Xx_NEWLINE_xXAdequate renal and hepatic functionXx_NEWLINE_xXAdequate hematological, liver and kidney function.Xx_NEWLINE_xXAdequate hematological, hepatic and renal function (renal function considered adequate as per protocol definition)Xx_NEWLINE_xXAdequate hepatic and renal functionXx_NEWLINE_xXAdequate cardiovascular functionXx_NEWLINE_xXHas adequate hematologic (bone marrow and coagulation factors), renal, and hepatic function as defined by criteria below:Xx_NEWLINE_xXHepatic function:Xx_NEWLINE_xXThe following criteria for evidence of adequate hepatic function performed within 4 weeks prior to randomization must be met:Xx_NEWLINE_xXAdequate hematologic, hepatic, and renal functionXx_NEWLINE_xXAdequate hematologic, liver, coagulation and kidney functionXx_NEWLINE_xXInclusion Criteria:\n\n        Patients with histologically or cytologically confirmed advanced solid malignancy or\n        Lymphoma\n\n        Relapsed or refractory disease after at least 1 prior systemic treatment for the primary\n        malignancy and not a candidate for other curative treatment.\n\n        Adequate hematologic status\n\n        Adequate coagulation function\n\n        Adequate hepatic function\n\n        Adequate renal function\n\n        Exclusion Criteria:\n\n        Known primary tumors of central nervous system disease\n\n        Known active brain metastases\n\n        Known cardiopulmonary diseaseXx_NEWLINE_xXAdequate hematological, renal, hepatic, and coagulation laboratory assessmentsXx_NEWLINE_xXAdequate renal, hepatic and pancreatic functionXx_NEWLINE_xXRisk of hepatic or renal failureXx_NEWLINE_xXAdequate renal, hepatic, and hematologic functions per protocol-defined laboratory parameters within ? 7 days before treatment initiation.Xx_NEWLINE_xXAdequate liver function:Xx_NEWLINE_xXInadequate hematologic, renal, and liver function (unless due to underlying lymphoma)Xx_NEWLINE_xXAdequate liver and renal functionXx_NEWLINE_xXHave adequate organ function including hematology, renal, and liver.Xx_NEWLINE_xXAdequate hematologic function:Xx_NEWLINE_xXAdequate hepatic and renal function defined as:Xx_NEWLINE_xXAbnormal hematological, renal, or liver functionXx_NEWLINE_xXAdequate liver functionXx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXAdequate renal function: serum creatinine <2.5mg/dLXx_NEWLINE_xXAdequate hematologic, renal and hepatic function, specifically:Xx_NEWLINE_xXHepatic function:Xx_NEWLINE_xXAdequate hematological, hepatic and renal functions.Xx_NEWLINE_xXAdequate renal, and hematologic functionXx_NEWLINE_xXAdequate hematologic functionXx_NEWLINE_xXInadequate renal or liver functionXx_NEWLINE_xXAcceptable renal functionXx_NEWLINE_xXAdequate renal, hepatic, and hematologic indices for ipilimumab therapyXx_NEWLINE_xXInadequate hematologic, renal, or hepatic functionXx_NEWLINE_xXAdequate liver function, defined as:Xx_NEWLINE_xXAdequate hematologic, hepatic, renal, and coagulation functionsXx_NEWLINE_xXAdequate coagulation, renal and hepatic functionXx_NEWLINE_xXAdequate hematologic, hepatic, and renal functionXx_NEWLINE_xXSubject has adequate hematologic, hepatic, renal, and coagulation functionXx_NEWLINE_xXAdequate cardiac function as assessed clinicallyXx_NEWLINE_xXAdequate cardiac function as measured by echocardiogramXx_NEWLINE_xXAdequate renal and hepatic functionXx_NEWLINE_xXAdequate organ function as per pre-defined hematologic, hepatic, renal, and cardiac criteria.Xx_NEWLINE_xXInadequate hematological, liver, renal, cardiac functionXx_NEWLINE_xXAdequate hepatic, renal, cardiac, and hematologic functionXx_NEWLINE_xXAdequate hematologic statusXx_NEWLINE_xXAdequate coagulation functionXx_NEWLINE_xXAdequate hepatic functionXx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXAdequate renal, hepatic, pulmonary and cardiac function defined as:Xx_NEWLINE_xXAdequate hematological, hepatic and renal function as defined in the protocolXx_NEWLINE_xXAdequate hepatic, hematologic, and renal functionXx_NEWLINE_xXInadequate hematologic function, renal function, and liver functionXx_NEWLINE_xXAdequate renal function (defined as serum creatinine =< 1.5 X ULN)Xx_NEWLINE_xXSubject has inadequate marrow, hepatic, and/or renal function at the Screening Visit defined as:Xx_NEWLINE_xXAdequate hematological and biological functionXx_NEWLINE_xXInadequate hematologic or hepatic functionXx_NEWLINE_xXAdequate hematological, renal, metabolic and hepatic functionXx_NEWLINE_xXAdequate hematologic function:Xx_NEWLINE_xXAdequate hepatic and renal function:Xx_NEWLINE_xXAdequate hematological, renal, hepatic and coagulation laboratory test results.Xx_NEWLINE_xXAdequate hematologic, hepatic, and renal function, defined by:Xx_NEWLINE_xXAdequate hepatic function within 28 days prior to registration for protocol therapy defined as meeting all of the following criteria:Xx_NEWLINE_xXAdequate renal function within 28 days prior to registration for protocol therapy defined by either of the following criteria:Xx_NEWLINE_xXAdequate hematologic function within 28 days prior to registration for protocol therapy defined as meeting all of the following criteria:Xx_NEWLINE_xXPatient has adequate hepatic function defined as:Xx_NEWLINE_xXPatient has adequate renal function defined as: Serum creatinine ?1.5 the institutional ULNXx_NEWLINE_xXInadequate renal functionXx_NEWLINE_xXPatients must have adequate hepatic function, defined asXx_NEWLINE_xXSeriously limited cardiac, renal, or hepatic functionXx_NEWLINE_xXAdequate liver functionXx_NEWLINE_xXInadequate renal functionXx_NEWLINE_xXHepaticXx_NEWLINE_xXRenalXx_NEWLINE_xXSubject must have adequate coagulation profile, renal, and hepatic function, per laboratory reference range at ScreeningXx_NEWLINE_xXAdequate hepatic, renal and pancreatic function.Xx_NEWLINE_xXAdequate hematological function defined as:Xx_NEWLINE_xXAdequate liver function defined as:Xx_NEWLINE_xXSubjects must have adequate hepatic function as evidenced by:Xx_NEWLINE_xXAdequate hematologic, hepatic, and renal functionXx_NEWLINE_xXAdequate renal and hepatic functionXx_NEWLINE_xXGrossly normal pulmonary, cardiac function, renal, hepatic hematologic and performance functionsXx_NEWLINE_xXAdequate hematologic function as defined by:Xx_NEWLINE_xXAdequate hepatic function is defined by the following:Xx_NEWLINE_xXInadequate hematologic, renal or liver functionXx_NEWLINE_xXAdequate liver function, defined as both of the following:Xx_NEWLINE_xXAdequate hematologic, renal and hepatic function.Xx_NEWLINE_xXHas adequate hematologic, hepatic, and renal function as defined by the protocolXx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXAdequate liver functionXx_NEWLINE_xXAdequate cardiac functionXx_NEWLINE_xXAdequate neurologic functionXx_NEWLINE_xXAdequate pancreatic functionXx_NEWLINE_xXAdequate hematological, hepatic and renal function as defined in the protocolXx_NEWLINE_xXSubjects must have adequate hepatic function as evidenced by:Xx_NEWLINE_xXAdequate renal and hepatic function.Xx_NEWLINE_xXAdequate liver function, defined as:Xx_NEWLINE_xXSubject must have adequate coagulation, renal, and hepatic function, per laboratory reference range at Screening.Xx_NEWLINE_xXAdequate cardiac functionXx_NEWLINE_xXInadequate hematologic, renal or liver functionXx_NEWLINE_xXAdequate hematologic, renal and liver functionXx_NEWLINE_xXAdequate hematological, renal and hepatic functionXx_NEWLINE_xXAdequate coagulation, renal and hepatic functionXx_NEWLINE_xXAdequate hematologic, hepatic, renal and cardiac function.Xx_NEWLINE_xXHave adequate blood counts, hepatic and renal functionXx_NEWLINE_xXAdequate renal function, defined as serum creatinine ?1.5x ULNXx_NEWLINE_xXSubject must have adequate coagulation, renal, and hepatic function, per laboratory reference range at Screening.Xx_NEWLINE_xXAdequate hepatic function as evidenced by serum bilirubin values < 2.0 mg/dL; ALT and/or AST < 3xULN.Xx_NEWLINE_xXAdequate hematologic, hepatic and renal functionXx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXAdequate hepatic functionXx_NEWLINE_xXAdequate renal, hepatic, and hematologic indices for ipilimumab therapyXx_NEWLINE_xXAdequate renal and hepatic function (creatinine <2mg/dL and eGFR more than 30cc/minute, bilirubin <2mg/dL). Patients with renal or liver dysfunction due to organ infiltration by lymphocytes may be eligible after discussion with the study chairman. Patients with Gilbert's syndrome are eligible.Xx_NEWLINE_xXHave adequate hematologic, hepatic, and renal functionXx_NEWLINE_xXAdequate hematologic functionXx_NEWLINE_xXSubject must have adequate coagulation, renal, and hepatic function, per laboratory reference range at Screening.Xx_NEWLINE_xXHave adequate hematologic, hepatic and renal functionXx_NEWLINE_xXAdequate kidney functionXx_NEWLINE_xXAdequate liver functionXx_NEWLINE_xXHave clinically adequate hepatic and renal functions as defined by:Xx_NEWLINE_xXPatients must have adequate renal function (creatinine < 1.5 mg/dL) before starting therapy and the test must be performed within 14 days prior to registrationXx_NEWLINE_xXHepaticXx_NEWLINE_xXRenalXx_NEWLINE_xXAdequate hematologic, hepatic and renal function.Xx_NEWLINE_xXAdequate hematologic, hepatic and renal function as assessed by the following laboratory requirements conducted within 7 days of starting study treatment:Xx_NEWLINE_xXHave adequate hematologic function, defined as meeting all of the following criteria:Xx_NEWLINE_xXAdequate hematologic function within protocol-defined parameters.Xx_NEWLINE_xXAdequate hepatic and renal function within protocol-defined parameters.Xx_NEWLINE_xXAdequate hepatic function with bilirubin < 1.5 mg/dlXx_NEWLINE_xXAdequate cardiac and renal functionXx_NEWLINE_xXAdequate hepatic and renal functionXx_NEWLINE_xXAdequate cardiac function as assessed clinically.Xx_NEWLINE_xXAdequate hematologic, hepatic, and renal functionXx_NEWLINE_xXAdequate baseline renal and hepatic functionXx_NEWLINE_xXHas adequate hematologic, renal, cardiac and hepatic function.Xx_NEWLINE_xXMust have adequate hematologic, renal, and liver functionXx_NEWLINE_xXAdequate hematologic, hepatic, and renal function.Xx_NEWLINE_xXAdequate hematological, liver and kidney function.Xx_NEWLINE_xXAdequate hepatic function.Xx_NEWLINE_xXAdequate renal function.Xx_NEWLINE_xXAdequate pulmonary, renal, hepatic, and cardiac functionXx_NEWLINE_xXSubject has the following laboratory parameters at screening: Adequate hematologic function including:Xx_NEWLINE_xXAdequate hematological and biological function, confirmed by defined laboratory valuesXx_NEWLINE_xXAdequate hematologic, hepatic, cardiac, and renal functionXx_NEWLINE_xXAdequate hematologic, hepatic, and renal function.Xx_NEWLINE_xXAdequate baseline renal and hepatic functionXx_NEWLINE_xXAdequate hematological function, defined as:Xx_NEWLINE_xXAdequate liver function, defined as:Xx_NEWLINE_xXAdequate hematological function, defined as:Xx_NEWLINE_xXAdequate liver function, defined as:Xx_NEWLINE_xXAdequate hematological, renal, hepatic, and coagulation laboratory assessmentsXx_NEWLINE_xXAdequate hepatic and renal function defined as:Xx_NEWLINE_xXAdequate hematological, liver, and renal functionXx_NEWLINE_xXNot adequate hematologic, renal and hepatic functionXx_NEWLINE_xXPatient having out of range laboratory values defined as: Hepatic and renal function:Xx_NEWLINE_xXAdequate renal and liver functionXx_NEWLINE_xXMust have adequate hematological functionXx_NEWLINE_xXMust have adequate renal functionXx_NEWLINE_xXMust have adequate hepatic functionXx_NEWLINE_xXPatients must be suitable candidates for treatment with standard regimens; this includes having adequate hematologic parameters, liver function and renal function based on labs that are deemed acceptable for treatment by the investigatorsXx_NEWLINE_xXAdequate hematologic, renal, and hepatic function.Xx_NEWLINE_xXAdequate white blood cell counts (with low blast counts), liver function, and renal functionXx_NEWLINE_xXAcceptable hematological status, liver and renal function as defined in the protocolXx_NEWLINE_xXhave adequate hepatic function and renal functionXx_NEWLINE_xXInadequate renal function (Blood creatinine > 1.5 times the institutional ULN)Xx_NEWLINE_xXAdequate hepatic functionXx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXAcceptable renal functionXx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXAdequate hematologic, hepatic, renal functionXx_NEWLINE_xXAdequate renal function, defined by serum creatinine ? 1.5 x ULN.Xx_NEWLINE_xXAdequate hepatic functionXx_NEWLINE_xXAdequate hematological, renal and liver functionXx_NEWLINE_xXPatients must have adequate liver functionXx_NEWLINE_xXPatients must have adequate renal function as defined by a serum creatinine =< 1.5 times ULN within one week prior to treatmentXx_NEWLINE_xXAdequate hematologic function, as defined by the following criteria:Xx_NEWLINE_xXAdequate renal and hepatic function, as defined by the following criteria:Xx_NEWLINE_xXAdequate coagulation function as defined by the following criteria:Xx_NEWLINE_xXAdequate blood, liver, and kidney function as defined by laboratory tests.Xx_NEWLINE_xXAdequate hematological, hepatic, and renal function:Xx_NEWLINE_xXHas adequate hepatic function as evidenced by:Xx_NEWLINE_xXSubjects must have adequate liver functionXx_NEWLINE_xXSubjects must have adequate kidney functionXx_NEWLINE_xXPoor hematologic, renal, or hepatic functionXx_NEWLINE_xXAdequate liver function, defined as:Xx_NEWLINE_xXAdequate hematologic function.Xx_NEWLINE_xXAdequate hematologic, hepatic, and renal function:Xx_NEWLINE_xXAdequate renal, hepatic, pulmonary and cardiac function defined as:Xx_NEWLINE_xXPatients must have adequate bone marrow function (ANC >/= 1,500/mm3 and platelet count of >/= 100,000/mm3), adequate liver function (SGPT and serum glutamate oxaloacetate transaminase (SGOT) </= 2.5 times normal, bilirubin </= 2 mg/dl), and adequate renal function (BUN and creatinine </=1.5 times institutional normal) prior to starting therapy.Xx_NEWLINE_xXPatients must have adequate hepatic function as documented by a serum bilirubin less than or equal to 2.5 mg/dL.Xx_NEWLINE_xXAdequate hematological, renal, hepatic, and coagulation laboratory assessmentsXx_NEWLINE_xXInadequate hematopoietic, liver, endocrine or renal functionXx_NEWLINE_xXAdequate baseline renal and hepatic functionXx_NEWLINE_xXAdequate baseline hematologic, pulmonary, renal, and hepatic functionXx_NEWLINE_xXAdequate hematologic, kidney and liver functionXx_NEWLINE_xXAdequate haematological, liver and renal functionXx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXAdequate hematological, renal, hepatic and coagulation laboratory test resultsXx_NEWLINE_xXAdequate liver, renal and cardiac functionXx_NEWLINE_xXAdequate hematological, renal, and hepatic functionXx_NEWLINE_xXAdequate hepatic, renal, and cardiac functionXx_NEWLINE_xXAdequate hematological, renal, hepatic, and coagulation laboratory assessmentsXx_NEWLINE_xXAdequate hematologic, hepatic and renal functionXx_NEWLINE_xXPatient must have adequate renal function documented by a serum creatinine of ? 1.5 times the ULN for the reference lab.Xx_NEWLINE_xXAdequate hematological, renal and liver function For solid tumors only:Xx_NEWLINE_xXRenal and Hepatic FunctionXx_NEWLINE_xXReproductive FunctionXx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXAdequate liver functionXx_NEWLINE_xXAdequate cardiac functionXx_NEWLINE_xXnormal immune functionXx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXAdequate liver function within 72 hours of enrollment, defined as:Xx_NEWLINE_xXAdequate renal function, defined as serum creatinine ? 1.5x ULNXx_NEWLINE_xXAdequate hematological and biological function; LVEF ?50%Xx_NEWLINE_xXAcceptable renal functionXx_NEWLINE_xXAdequate hepatic and renal function defined as:Xx_NEWLINE_xXAdequate hematologic function:Xx_NEWLINE_xXAdequate hepatic and renal function:Xx_NEWLINE_xXAdequate hematologic, renal and hepatic functionXx_NEWLINE_xXNo prior anticancer therapy for pancreatic cancer •? 18 years of age with a performance status of 0 or 1•Adequate complete blood counts, hepatic function, and renal functionXx_NEWLINE_xXAdequate hematologic function defined by:Xx_NEWLINE_xXHave renal and hepatic function as defined by:Xx_NEWLINE_xXAdequate cardiac function:Xx_NEWLINE_xXAdequate hematologic functionXx_NEWLINE_xXChemistry, liver function tests, renal function, total CPK and hematology lab results must be ? Grade 1 at the time of screening;Xx_NEWLINE_xXRenal and Hepatic Function: Patient must have adequate renal and hepatic functions as indicated by the following laboratory values:Xx_NEWLINE_xXAdequate hematologic, liver, coagulation, renal, and cardiovascular functionXx_NEWLINE_xXAdequate renal function as evidenced by serum creatinine ? 2.0 mg/dL (177 µmol/L)Xx_NEWLINE_xXAdequate hematology, hepatic and renal function laboratory values within 14 days prior to first dose of study drug.Xx_NEWLINE_xXAdequate hepatic, renal, cardiac and hematological functionXx_NEWLINE_xXAdequate renal and hepatic functionXx_NEWLINE_xXAdequate hematologic, renal and hepatic functionXx_NEWLINE_xXAdequate hematology, liver and renal function laboratory values within 14 days prior to first dose of study treatment.Xx_NEWLINE_xXHave adequate complete blood counts and liver function testsXx_NEWLINE_xXHave adequate cardiac functionXx_NEWLINE_xXAdequate hematological, renal, metabolic and hepatic functionXx_NEWLINE_xXAdequate baseline renal and hepatic functionXx_NEWLINE_xXSubject must have adequate hematologic, renal and hepatic function as follows:Xx_NEWLINE_xXFor subjects with SEVERELY IMPAIRED renal function:Xx_NEWLINE_xXInadequate hematological, hepatic, or renal functionXx_NEWLINE_xXPatients must have adequate hepatic function, defined as:Xx_NEWLINE_xXAdequate renal and hepatic function and hematopoietic capacityXx_NEWLINE_xXAdequate hematologic, hepatic and renal functionXx_NEWLINE_xXAdequate hepatic and renal functionXx_NEWLINE_xXInadequate hematologic, hepatic or renal functionXx_NEWLINE_xXAdequate hematological function (as defined in the study protocol)Xx_NEWLINE_xXAdequate renal function (as defined in the study protocol)Xx_NEWLINE_xXAdequate liver function (as defined in the study protocol)Xx_NEWLINE_xXAdequate hematological, renal, hepatic, and coagulation laboratory assessmentsXx_NEWLINE_xXHepatic:Xx_NEWLINE_xXRenal:Xx_NEWLINE_xXHematologic function, as follows:Xx_NEWLINE_xXRenal function, as follows:Xx_NEWLINE_xXHepatic function, as follows:Xx_NEWLINE_xXRenal function:Xx_NEWLINE_xXThe patient has adequate organ function, including cardiac, renal, and hepatic function:Xx_NEWLINE_xXAdequate hematological function unless inadequate function is due to underlying diseaseXx_NEWLINE_xXEvidence of laboratory abnormalities in standard renal, hepatic, or coagulation function testsXx_NEWLINE_xXAdequate hepatic, renal, cardiac and hematologic functionXx_NEWLINE_xXAdequate hematologic, hepatic and renal function as defined by laboratory assessmentXx_NEWLINE_xXAdequate hematological and biological functionXx_NEWLINE_xXAdequate hepatic and renal functionXx_NEWLINE_xXAbnormal renal function tests (creatinine > 1.5)Xx_NEWLINE_xXParticipants must have adequate hepatic and kidney function.Xx_NEWLINE_xXAdequate hematologic, renal and liver functionXx_NEWLINE_xXInadequate hematologic, liver, or renal functionXx_NEWLINE_xXAdequate liver and renal functionsXx_NEWLINE_xXAdequate hematologic, liver, and renal functionXx_NEWLINE_xXHematological function, as follows:Xx_NEWLINE_xXHepatic function, as follows:Xx_NEWLINE_xXAdequate hematological, renal and liver functionXx_NEWLINE_xXAdequate hematological functionXx_NEWLINE_xXAdequate renal function:Xx_NEWLINE_xXAdequate hepatic function:Xx_NEWLINE_xXNormal renal function: estimated CrCl ?90 ml/minXx_NEWLINE_xXHematologic, liver, and renal function as specified in the study protocol.Xx_NEWLINE_xXParticipants with adequate hematological, liver, and renal functionXx_NEWLINE_xXAdequate hepatic and renal functionXx_NEWLINE_xXHas adequate hematologic, liver, and renal functionXx_NEWLINE_xXAdequate liver function, defined as:Xx_NEWLINE_xXAdequate hematologic, renal, and liver functionsXx_NEWLINE_xXAdequate hematologic and renal function as determined by laboratory blood and urine testsXx_NEWLINE_xXHas adequate hematologic, coagulation, hepatic and renal functionXx_NEWLINE_xXAdequate hematologic function, hepatic function, renal function and coagulation functionXx_NEWLINE_xXAdequate hepatic function per institutional standardsXx_NEWLINE_xXadequate renal, hepatic and pancreatic functionXx_NEWLINE_xXAdequate hepatic and renal function defined as:Xx_NEWLINE_xXRenal Function Creatinine >1.5 mg%Xx_NEWLINE_xXPatients with history of renal or hepatic insufficiency.Xx_NEWLINE_xXAdequate liver function, as indicated by bilirubin =< 1.5 x ULNXx_NEWLINE_xXAdequate Renal functionXx_NEWLINE_xXAdequate Hepatic functionsXx_NEWLINE_xXAdequate renal function.Xx_NEWLINE_xXAdequate hepatic function.Xx_NEWLINE_xXAdequate cardiac function.Xx_NEWLINE_xXAdequate hepatic and renal function defined as:Xx_NEWLINE_xXAdequate hematological, renal and hepatic function.Xx_NEWLINE_xXAdequate hematologic function.Xx_NEWLINE_xXAdequate renal function.Xx_NEWLINE_xXAdequate hepatic function.Xx_NEWLINE_xXAdequate pulmonary functionXx_NEWLINE_xXInadequate hematologic function as evidenced by any of the following:Xx_NEWLINE_xXHepatic and renal function meeting the strata as outlined below; nota bene (NB): patients must fulfill both total bilirubin and serum glutamic-oxaloacetic transaminase (SGOT)/aspartate aminotransferase (AST) criteria and creatinine function to be included in a group; however, if a patient’s total bilirubin and SGOT/AST and creatinine levels indicate different groups, the patient may be enrolled in the indicated group with the greatest degree of liver dysfunction; all liver and renal function tests must be completed within 24 hours prior to the start of treatment; Note: patients on dialysis will not be eligible\r\n* Group A: hepatic function: normal function (bilirubin =< upper limit of normal [ULN]; AST =< ULN); renal function: normal function (creatinine clearance [CrCl] >= 60 mL/min) \r\n* Group B: hepatic function: normal function (bilirubin =< ULN; AST =< ULN); renal function: moderate dysfunction (CrCl >= 30 and < 60 ml/min)\r\n* Group C: hepatic function: normal function (bilirubin =< ULN; AST =< ULN); renal function: severe dysfunction (CrCl >= 15 and < 30 ml/min)\r\n* Group D: hepatic function: mild dysfunction D1: bilirubin =< ULN; AST > ULN, D2: bilirubin > ULN and =< 1.5 x ULN; any AST; renal function: normal function (creatinine clearance [CrCl] >= 60 mL/min)\r\n* Group E: hepatic function: mooderate dysfunction (bilirubin 1.5 x > ULN and =< 3 x ULN; any AST); renal function: normal function (creatinine clearance [CrCl] >= 60 mL/min)\r\n* Group F: hepatic function: severe dysfunction (bilirubin > 3 x ULN and up to investigator’s discretion; any AST); renal function: normal function (creatinine clearance [CrCl] >= 60 mL/min)Xx_NEWLINE_xXPatients with solitary kidneys, bilateral renal tumors, compromised renal function (baseline creatinine > 1.4)Xx_NEWLINE_xXPatients must have adequate hepatic, hematologic and renal functioning to be able to be administered anastrozole at the discretion of the treating physicianXx_NEWLINE_xXHave adequate liver function defined as:Xx_NEWLINE_xXHave adequate heart function defined as:Xx_NEWLINE_xXParticipants with adequate hematologic, hepatic, and renal function.Xx_NEWLINE_xXRenal function at screening and enrollment as defined by the Modification of Diet in Renal Disease (MDRD) equation.Xx_NEWLINE_xXParticipant must have adequate hematologic, renal, and hepatic function.Xx_NEWLINE_xXAdequate liver function:Xx_NEWLINE_xXRenal failureXx_NEWLINE_xXAdequate hematologic function as indicated by:Xx_NEWLINE_xXAdequate renal and liver function as indicated by:Xx_NEWLINE_xXAdequate hepatic function defined as:Xx_NEWLINE_xXAdequate renal and hepatic functionXx_NEWLINE_xXAdequate hematological, hepatic, renal and cardiac functionXx_NEWLINE_xXPatients must have normal renal function test and no prior renal disease; the screening cut off for serum creatinine is < 1.5 mg/dLXx_NEWLINE_xXPatients with normal renal function according to MD Anderson testing standards and no prior renal diseaseXx_NEWLINE_xXMinocycline trial only: patients with adequate hepatic function according to MD Anderson testing standardsXx_NEWLINE_xXHave adequate hematopoietic, hepatic, and renal function at a screening visitXx_NEWLINE_xXParticipants with renal insufficiency or failure, as determined by a point of care renal function blood test.Xx_NEWLINE_xXRenal: Adequate renal functionXx_NEWLINE_xXAdequate cardiac, renal, and hepatic functions.Xx_NEWLINE_xXCardiac and pulmonary function that is adequate for ASCTXx_NEWLINE_xXAdequate hepatic reserveXx_NEWLINE_xXAdequate renal functionXx_NEWLINE_xXPatient has adequate hematologic, hepatic, and renal function as defined by:Xx_NEWLINE_xXPatients with renal failure are eligible; however, patients with pre-existing renal insufficiency will likely have further compromise in renal function and may require dialysisXx_NEWLINE_xXChronic renal diseases and hepatic cirrhosisXx_NEWLINE_xXAdequate hematological and biological function, confirmed by defined laboratory valuesXx_NEWLINE_xXAdequate hematological, liver and kidney function.Xx_NEWLINE_xXAdequate hematological, renal, hepatic, and coagulation laboratory assessmentsXx_NEWLINE_xXPatients must not have evidence of significant hematologic, renal, or hepatic dysfunctionXx_NEWLINE_xXAdequate hepatic, renal, cardiac, and hematologic functionXx_NEWLINE_xXCompromised renal functionXx_NEWLINE_xXPatients must have adequate liver function as defined by AST or ALT <10x normalXx_NEWLINE_xXAdequate hematologic, hepatic, and renal function, as evidenced by:Xx_NEWLINE_xXInadequate hepatic functionXx_NEWLINE_xXInadequate renal functionXx_NEWLINE_xXAdequate renal function: serum creatinine ? 1.5x ULN;Xx_NEWLINE_xXParticipants with renal insufficiency or failure, as determined by a point of care renal function blood testXx_NEWLINE_xXPatients with impaired renal function (eGFR < 30)Xx_NEWLINE_xXNo evidence of impaired hepatic or kidney functionXx_NEWLINE_xXAdequate performance status and hematological, liver, and kidney functionXx_NEWLINE_xXAdequate hematologic, hepatic, and renal functionXx_NEWLINE_xXAdequate renal, hepatic, cardiac, and pulmonary function as evidenced by:Xx_NEWLINE_xXAdequate hematologic, hepatic, and renal function.Xx_NEWLINE_xXAdequate hepatic function within 28 days prior to C1D1Xx_NEWLINE_xXAdequate renal function within 28 days prior to C1D1Xx_NEWLINE_xXAdequate hematopoietic function within 7 days prior to C1D1Xx_NEWLINE_xXHas adequate renal and hepatic functionXx_NEWLINE_xXAdequate liver function:Xx_NEWLINE_xXAdequate hematological, liver, and renal functionsXx_NEWLINE_xXAdequate organ functions (hematological, hepatic, renal function)Xx_NEWLINE_xXCriteria 8, Adequate organ function within 4 wks prior to enrollment. This includes hematology, renal, hepatic and blood-clotting functions as defined by protocol.Xx_NEWLINE_xXAdequate renal function defined as:Xx_NEWLINE_xXAdequate liver function defined as:Xx_NEWLINE_xXAdequate coagulation defined as:Xx_NEWLINE_xXAdequate hematological, renal, and hepatic functionXx_NEWLINE_xXAdequate function of kidney:Xx_NEWLINE_xXAdequate function of liver:Xx_NEWLINE_xXAdequate liver function:Xx_NEWLINE_xXPatient has adequate hematologic, hepatic, and renal functionsXx_NEWLINE_xXAdequate hematologic, immunologic, liver and renal function, defined asXx_NEWLINE_xX