Human immunodeficiency virus (HIV)-positive patients are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; patients must also have a CD4 count > 350 cells/mm^3 with an undetectable viral loadXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; however, HIV patients treated with regimens that have low cytochrome P450 (CYP450) inhibition may be allowed as long as the patient’s general health and cluster of differentiation (CD)4 counts are within acceptable levelsXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPatients who are known to have human immunodeficiency virus (HIV) or are on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are INELIGIBLEXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPatients on antiretroviral therapy.Xx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligible; HIV testing is not required for inclusion in this studyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in participants receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHas a known history of human immunodeficiency virus (HIV) (HIV 1/2 antibodies); HIV-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible due to potential drug-drug interactions with PT2385Xx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive participants; appropriate studies will be undertaken in participants receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in participants receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXParticipants known to be human immunodeficiency virus (HIV)-positive on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in participants receiving combination antiretroviral therapy when indicated; screening for HIV infection at baseline is not requiredXx_NEWLINE_xXHuman immunodeficiency virus (HIV) positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXMedical history:\r\n* History of intracranial abscess within 6 months prior to start of study therapy\r\n* Known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)\r\n* NOTE: HIV-positive participants on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with nivolumab\r\n* Appropriate studies will be undertaken in participants receiving combination antiretroviral therapy when indicated\r\n* History of allergy to study drug components\r\n* History of severe hypersensitivity reaction to any monoclonal antibody;Xx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown history of human immunodeficiency virus (HIV); testing is not required in the absence of prior documentation or known history; HIV-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; it is not necessary to conduct HIV testing at screening; patients who are HIV-positive with undetectable viral loads, not on interacting antiretroviral therapy, and have CD4 counts above 300/mm^3 may be eligible after discussion with the principal investigatorXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapyXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive on combination antiretroviral therapyXx_NEWLINE_xXKnown HIV-positive patients on combination antiretroviral therapy.Xx_NEWLINE_xXThe participant is known to be positive for the human immunodeficiency virus (HIV), hepatitis B surface antigen (HepBsAg), or hepatitis C virus (HCV) ribonucleic acid (RNA). HIV-positive participants on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with atezolizumabXx_NEWLINE_xXThe participant is known to be positive for the human immunodeficiency virus (HIV), hepatitis B surface antigen (HepBsAg), or hepatitis C (HCV) ribonucleic acid (RNA); HIV-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXActive infection or ongoing antiviral medication for viral infections including hepatitis B, hepatitis C, or human immunodeficiency virus (HIV); screening for chronic conditions is not required; HIV-positive participants on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with selumetinib or osimertinibXx_NEWLINE_xXENROLLMENT TO THE DOSE ESCALATION, EXPANSION AND PART II: Known human immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive and on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXParticipants with a known history of human immunodeficiency virus (HIV) are ineligible; appropriate studies will be undertaken in participants receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination anti-retroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXThe participant is known to be positive for the human immunodeficiency virus (HIV), hepatitis B surface antigen (HepBsAg), or hepatitis C virus (HCV) ribonucleic acid (RNA); HIV-positive participants on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with pembrolizumabXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapyXx_NEWLINE_xXA known history of human immunodeficiency virus (HIV) seropositivity; HIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive participants; HIV-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in participants receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXPatients may not have known human immunodeficiency virus (HIV) infection; HIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive participants are ineligible; appropriate studies will be undertaken in participants receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXPatients with human immunodeficiency virus (HIV) who are unable or unwilling to stop antiretroviral therapy for the duration of therapy may not be enrolledXx_NEWLINE_xXKnown to be human immunodeficiency virus (HIV)-positive on combination antiretroviral therapy; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in participants receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPatients known to be human immunodeficiency virus (HIV) positive and currently receiving antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving anti-retroviral therapy are excluded from this study; HIV positive patients not receiving antiretroviral therapy are excludedXx_NEWLINE_xXPatients with active human immunodeficiency virus (HIV) or hepatitis C; (HIV-positive patients on combination antiretroviral therapy or hepatitis C-positive patients on antiviral therapy are ineligible)Xx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; HIV-positive patients who are not on highly active anti-retroviral therapy (HAART) and have CD4 counts > 500 will be considered on an individual basisXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study; appropriate studies will be undertaken in patients receiving combination anti-retroviral therapy when indicated; note: HIV testing is not required for entry into this protocolXx_NEWLINE_xXPatients with known prior human immunodeficiency virus (HIV)-positive status on combination antiretroviral therapy are ineligible; known prior HIV-positive patients with cluster of differentiation (CD)4+ =< 500/mm^3 are ineligible (HIV testing is not required as part of this study)Xx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV) positive patients on antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving combination antiretroviral therapy are excluded from the studyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPatient known to be human immunodeficiency virus (HIV)-positive and requiring antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with chemotherapeutic drugs. In addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapy.Xx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions vemurafenib and cobimetinibXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with study drug. In addition, these participants are at increased risk of lethal infections when treated with marrow-suppressive therapyXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapy; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study; appropriate studies will be undertaken in patients receiving combination anti-retroviral therapy when indicated; Note: HIV testing is not required for entry into this protocolXx_NEWLINE_xXCOHORT 1: HORMONE RECEPTOR POSITIVE BREAST CANCER: Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXCOHORT 2: TRIPLE NEGATIVE BREAST CANCER: HIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXCOHORT 3: ENDOMETRIAL CANCER: HIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity and on combination antiretroviral therapyXx_NEWLINE_xXIndividuals who are known to be human immunodeficiency virus (HIV)-positive on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPatients with human immunodeficiency virus (HIV) on antiretroviral therapy are ineligibleXx_NEWLINE_xXThe participant is known to be positive for the human immunodeficiency virus (HIV), hepatitis B surface antigen (HepBsAg), or hepatitis c virus (HCV) ribonucleic acid (RNA); HIV-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive test on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with apalutamide and abiraterone. Appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated.Xx_NEWLINE_xXPatients known to be human immunodeficiency virus (HIV)-positive patients and on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with the study drugs. In addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapy. Appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated.Xx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with meclizine.Xx_NEWLINE_xXHuman deficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV) seropositive patients with acceptable organ function who meet the patient selection criteria, and who are not on combination antiretroviral therapy, and whose absolute CD4+ count is >= 400 cells per cubic millimeter of blood, will be eligible; however, HIV positive patients on combination antiretroviral therapy will be ineligible, because of the potential for pharmacokinetic interactions with cabozantinibXx_NEWLINE_xXImmunocompromised patients and patients known to be human immunodeficiency virus (HIV) positive and currently receiving antiretroviral therapyXx_NEWLINE_xXPatients who are known human immunodeficiency virus (HIV), hepatitis B or hepatitis C positive; HIV-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated; HIV, hepatitis B and hepatitis C testing is not required for patients not known to have those infectionsXx_NEWLINE_xXParticipants known to be human immunodeficiency virus (HIV)-positive and on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in participants receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving anti-retroviral therapy are excluded from this study; HIV positive patients not receiving antiretroviral therapy are excludedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapyXx_NEWLINE_xXPatients with known human immunodeficiency virus (HIV) on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV) positive patients with CD4 counts below 500 OR who are not on a stable dose of antiretroviral therapy (for at least 1 month prior to registration) are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV) infection (with the exception of chronic or cleared HBV and HCV infection, which will be allowed)\r\n* HIV-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients who are on combination antiretroviral therapy; (this is because of the potential for pharmacokinetic interactions with denosumab)Xx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are eligible provided they have stable CD4 counts above 250Xx_NEWLINE_xXPatients on combination antiretroviral therapy, i.e. those who are human immunodeficiency virus (HIV)-positive, are ineligible; HIV testing is not required, but patients must not be known to be HIV-positiveXx_NEWLINE_xXPatients who are human immunodeficiency virus (HIV)-positive on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV) infection: HIV-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown history of human immunodeficiency virus (HIV) infection (testing not mandatory); NOTE: HIV-positive subjects on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with ribociclib; in addition, these subjects are at increased risk of lethal infections when treated with marrow suppressive therapy; appropriate studies will be undertaken in subjects receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients with uncontrolled HIV despite combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPatients on combination antiretroviral therapy for the treatment of human immunodeficiency virus (HIV) are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXImmunocompromised patients and patients known to be human immunodeficiency virus (HIV) positive and currently receiving antiretroviral therapyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS); HIV-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) infection\r\n* HIV-positive patients are at increased risk of lethal infections when treated with marrow suppressive therapy; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness (HIV-positive subjects on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with oral THU-Dec; appropriate studies will be undertaken in subjects receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXSubjects who are human immunodeficiency virus (HIV)-positive will be excluded from the study\r\n* Appropriate studies will be undertaken in subjects receiving combination antiretroviral therapy when indicated; also include whether HIV testing is required for this study, or only if a known diagnosis will be excludedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; in addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapy; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXPHASE I AND II SCLC AND UROTHELIAL CARCINOMA EXPANSION COHORT: Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXmCRPC EXPANSION COHORT: HIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnow human immunodeficiency virus (HIV) positivity on combination antiretroviral therapyXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity and on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV) positive (+) with a cluster of differentiation (CD)4 count < 200 are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the studyXx_NEWLINE_xXKnown history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS); HIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapy; in addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapy; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXPatients who are known to be human immunodeficiency positive (HIV)-positive and are on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; in addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with vandetanib/metforminXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapy; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXSubjects known to be human immunodeficiency virus (HIV)-positive, including those on combination antiretroviral therapy, are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXImmunocompromised patients or patients known to be human immunodeficiency virus (HIV) positive and currently receiving antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPatients with a known human immunodeficiency virus (HIV)-positive test on combination antiretroviral therapy are ineligible for the initial first-in-man trialXx_NEWLINE_xXThe subject is known to be positive for the human immunodeficiency virus (HIV) and is receiving antiretroviral therapies; subjects known to be HIV-positive who do not require antiretroviral therapy will be eligible if they meet other entry criteriaXx_NEWLINE_xXHIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPatients known to be human immunodeficiency virus (HIV)-positive patients and on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral treatment are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excludedXx_NEWLINE_xXHistory of human immunodeficiency virus (HIV) or HIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-infected patients should be receiving or willing to initiate an effective combination antiretroviral therapy (cART) regimenXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHIV positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPatients receiving antiretroviral therapy (highly active antiretroviral therapy [HAART]) for human immunodeficiency virus (HIV) infection are excluded from the studyXx_NEWLINE_xXPatients known to be human immunodeficiency virus (HIV) positive must be stable and currently receiving antiretroviral therapy with a CD4 count > 400Xx_NEWLINE_xXHuman immunodeficiency (HIV)-positive individuals on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with STA-9090; in addition, these individuals are at increased risk of lethal infections when treated with marrow-suppressive therapy; appropriate studies will be undertaken in participants receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHIV-positive patients on combination antiretroviral therapy are ineligible because of unknown potential for interactions with cenersen.Xx_NEWLINE_xXPregnant women are excluded from this study; breastfeeding should be discontinued if the mother is treated with copanlisib or nivolumab\r\n* Patients with human immunodeficiency virus (HIV): HIV-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated; patients with evidence of hepatitis B virus (HBV) are eligible provided there is minimal hepatic injury and the patient has undetectable HBV on suppressive HBV therapy; patient must be willing to maintain adherence to HBV therapy\r\n* Patients with previously treated and eradicated hepatitis C virus (HCV) who have minimal hepatic injury are eligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV) positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with lenvatinibXx_NEWLINE_xXImmunocompromised patients and patients known to be human immunodeficiency virus (HIV) positive and currently receiving antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the studyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on highly active antiretroviral therapy (HAART) are excludedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with AMG 232; in addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapyXx_NEWLINE_xXParticipants known to be human immunodeficiency virus (HIV)-positive are excluded (Note: HIV testing is not required prior to enrollment). HIV-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXImmunocompromised patients and patients known to be human immunodeficiency virus (HIV) positive and currently receiving antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are eligible so long as they meet all other criteria; known HIV-positive individuals who are not on combination antiretroviral therapy are not eligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXTUMOR BIOPSY SEQUENCING: Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXTREATMENT: HIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; however, HIV-positive patients without an acquired immune deficiency syndrome (AIDS)-defining diagnosis who are not receiving agents with the potential for pharmacokinetic (PK) interactions with ABT-888 may be eligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXImmunocompromised patients, e.g., patients who are known to be serologically positive for human immunodeficiency virus (HIV); HIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; HIV-positive patients not on antiviral therapy with undetectable viral loads and CD4 counts > 300, and after confirmation of eligibility after discussing with the study chair are eligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are eligible; unless the patient’s cluster of differentiation (CD)4+ count is below the institutional lower limit of normalXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPatients who are positive for human immunodeficiency virus type 1 (HIV-1) and are receiving combination anti-retroviral therapyXx_NEWLINE_xXHuman immunodeficiency (HIV)-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXParticipants known to be human immunodeficiency virus (HIV)-positive are excluded (note: HIV testing is not required prior to enrollment); HIV-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHas a known history of human immunodeficiency virus (HIV) (HIV 1/2 antibodies); HIV-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or other history of immunodeficiency disorder; HIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXImmunocompromised patients and patients known to be human immunodeficiency virus (HIV) positive and currently receiving antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the studyXx_NEWLINE_xXHIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; if an HIV-positive patient has adequate cluster of differentiation (CD4) counts (CD4 above the lower limit of institutional normal) and is on antiretroviral therapy with newer agents, which are not strong cytochrome (CYP) inhibitors, they will be eligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or other history of immunodeficiency disorder \r\n* NOTE: HIV-positive patients taking combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving combination antiretroviral therapy are excluded from the studyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are not eligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the studyXx_NEWLINE_xXHuman immunodeficiency virus (HIV) positive patients who are on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPHASE II: HIV-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with veliparib; in addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapy; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapyXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXNegative human immunodeficiency virus (HIV) blood test within 21 days of study entry; HIV-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients with well-controlled disease, as determined by CD4 count and viral load, who are on antiretroviral therapy that does not contain a strong inducer or inhibitor of CYP3A4 are allowed on trial; HIV-positive patients on combination antiretroviral therapy with strong inducers or inhibitors of CYP3A4 are ineligible; patients with poorly controlled HIV are not eligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPhase I and Arm 1 of Phase II: Known human immunodeficiency virus (HIV)-positivity and on combination antiretroviral therapy; Arms 2 and 3 of Phase II: patients with HIV infection and antiretroviral therapy are not excludedXx_NEWLINE_xXParticipant is known to be positive for the human immunodeficiency virus (HIV), hepatitis B surface antigen (HepBsAg), or hepatitis C virus (HCV) RNA; HIV-positive participants are ineligible because of the potential for pharmacokinetic interactions of combination antiretroviral therapy with study drugs; in addition, these participants are at increased risk of fatal infections when treated with marrow-suppressive therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHIV positive patients on antiretroviral therapy regimen must be willing to suspend all highly active antiretroviral therapy (HAART) except in circumstances describedXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the studyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are eligible; unless the patient’s CD4 count is below the institutional lower limit of normalXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligible; HIV testing is required only for patients deemed to be high-riskXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study; appropriate studies will be undertaken in patients receiving combination anti-retroviral therapy when indicatedXx_NEWLINE_xXPatients who are known to have human immunodeficiency virus (HIV) or are on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXSubjects known to be human immunodeficiency virus (HIV)-positive, including those on combination antiretroviral therapy, are ineligibleXx_NEWLINE_xXPatients who are human immunodeficiency virus (HIV) positive must be willing to comply with effective antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity and on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in subjects receiving combination antiretroviral therapy when indicated; HIV testing prior to enrollment is not required for screening but strongly encouraged for patients with no documented prior HIV assessmentXx_NEWLINE_xXHIV-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on CYP3A4 modulating antiretroviral therapy are ineligibleXx_NEWLINE_xXPatients on combination antiretroviral therapy, i.e. those who are human immunodeficiency virus (HIV)-positive, are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapyXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapyXx_NEWLINE_xXHIV-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; this applies only to patients who have a documented history of HIV and HIV testing is not otherwise requiredXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients with inadequate cluster of differentiation (CD)4 counts or those who are on combination antiretroviral therapy with strong cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) effects are ineligible for this trialXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXConfirmed human immunodeficiency virus (HIV) positive whether or not on antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPHASE II: Human immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are eligible so long as they meet all other criteria; HIV-positive individuals who are not on combination antiretroviral therapy are not eligibleXx_NEWLINE_xXPatients on combination antiretroviral therapy, i.e. those who are human immunodeficiency virus (HIV)-positive, are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) infected patients (HIV testing will not be performed as a part of screening) on combination antiretroviral therapy are eligible for inclusion; the use of zidovudine is not allowedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; Note: patients not on antiretroviral therapies are eligible for this studyXx_NEWLINE_xXBecause patients with immune deficiency are at increased risk of lethal infections when treated with bone marrow suppressive therapy, human immunodeficiency virus (HIV)-positive patients are excluded from the study; for patients receiving combination antiretroviral therapy, the potential impact of pharmacokinetic interactions with HCQ and VEM is unknown; appropriate studies may be undertaken in patients with HIV and those receiving combination anti-retroviral therapy in the futureXx_NEWLINE_xXHIV-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are eligible so long as they meet all other criteria; HIV-positive individuals who are not on combination antiretroviral therapy are not eligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients or those on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPatient must not be known to be human immunodeficiency virus (HIV)-positive on combination antiretroviral; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHIV-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with mFOLFIRINOX. In addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapy. Appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated.Xx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPatients must not have human immunodeficiency virus (HIV) or be taking highly active antiretroviral therapy (HAART) therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy will be eligible unless the cluster of differentiation (CD)4 count is < 200 cells/mm^3 within one month of study enrollmentXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are eligible for enrollment and will be monitored closely for potential pharmacokinetic interactions with neratinibXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHIV-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXEXPANSION COHORT ONLY: HIV-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown HIV-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with bevacizumab. In addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapy. Appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated.Xx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with vorinostat; in addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; HIV-positive patients with cluster of differentiation (CD)4+ =< 500/mm^3 are ineligible; appropriate studies will be undertaken in this group of patients when indicatedXx_NEWLINE_xXHIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; HIV- positive patients who are not on combination antiretroviral therapy (cART) and have CD4 counts > 500 are eligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown HIV-positive individuals on combination antiretroviral therapy.Xx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; known impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of oral everolimusXx_NEWLINE_xXPatients with human immunodeficiency virus (HIV) whom are not receiving antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are eligible, unless the patient’s cluster of differentiation (CD)4 count is below the institutional lower limit of normal, or the patient is taking prohibited CYP3A4/5 strong inhibitors or inducersXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients receiving combination antiretroviral therapy are ineligible; HIV testing is not required for study enrollment and optionalXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with tretinoin; in addition, these patients are at increased risk of lethal infections when treated with marrow suppressive therapy; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy; NOTE: HIV-positive patients on combination antiretroviral therapy are ineligible; in addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapyXx_NEWLINE_xXPatients that are human immunodeficiency virus (HIV)-positive on combination antiretroviral therapyXx_NEWLINE_xXPatient is human immunodeficiency virus (HIV)-positive and is receiving combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy known to interact with CYP isoenzymes are ineligible; in addition, HIV patients with CD4 count < 200 cells/uL are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHIV-positive patients on combination antiretroviral therapy.Xx_NEWLINE_xXHuman immunodeficiency virus-positive patients receiving combination anti-retroviral therapy are excluded from the studyXx_NEWLINE_xXHIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXSubjects who are human immunodeficiency virus (HIV)-positive on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness (HIV-positive subjects on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in subjects receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are eligible if they have been on antiretrovirals (ARVs) for >= 6 months and undetectable viral loadsXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligible; HIV-positive individuals on highly active antiretroviral therapy (HAART) will be considered eligible if they have demonstrated good compliance and have a cluster of differentiation (CD)4 count > 500Xx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are eligible, unless the patient’s CD4 count is below the institutional lower limit of normal, or the patient is taking prohibited CYP3A4/5 strong inhibitors or inducersXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excludedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPatient must not be known to be human immunodeficiency virus (HIV)-positive on combination antiretroviral; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with erlotinib; in addition, these patients are at increased risk of lethal infections; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman Immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving anti-retroviral therapy are excluded from this study; HIV positive patients not receiving antiretroviral therapy are excludedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the studyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the studyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on antiretroviral therapy are excluded from the studyXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; this applies only to patients who have a documented history of HIV; HIV testing is not otherwise requiredXx_NEWLINE_xXParticipants known to be positive for the human immunodeficiency virus (HIV), hepatitis B antigen (HepBsAg), or hepatitis C virus (HCV) ribonucleic acid (RNA); HIV-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in participants receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXPatient must not be known to be human immunodeficiency virus (HIV)-positive on combination antiretroviral therapiesXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positivity and on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHIV-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPatients with known human immunodeficiency virus (HIV) are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with ferumoxytolXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with ferumoxytolXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXPatient must not be known to be human immunodeficiency virus (HIV)-positive on combination antiretroviral therapyXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive individuals on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive participants on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with zolpidem; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicatedXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive patients on combination anti-retroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination anti-retroviral therapy when indicatedXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the studyXx_NEWLINE_xXHIV-positive individuals on combination antiretroviral therapy.Xx_NEWLINE_xXHIV-positive individuals on combination antiretroviral therapy.Xx_NEWLINE_xXHIV-positive individuals on combination antiretroviral therapy.Xx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligibleXx_NEWLINE_xX