Creatinine clearance and/or glomerular filtration rate (GFR) greater than or equal to 60 mL/min/1.73m^2 within 21 days of protocol therapy; kidney function cannot be estimated by other meansXx_NEWLINE_xXCalculated creatinine clearance or radioisotope glomerular filtration rate < 70 mL/min/1.73 m^2Xx_NEWLINE_xXALT ? 2.5 x ULN f. Estimated glomerular filtration rate of at least 50 mL/min by the Cockcroft Gault formulaXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 orXx_NEWLINE_xXRenal dysfunction for which exposure to cisplatin would be unsafe or require cisplatin dose modification (i.e., creatinine [Cre] > 1.5 mg/dl or glomerular filtration rate [GFR] < 60 cc/min)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2Xx_NEWLINE_xXGlomerular filtration rate (GFR) >= 35 mL/min estimated by Cockcroft-Gault or measured directly by 24 hour urine creatinine within 90 days prior to Step 1 registrationXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 orXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 orXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 orXx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) (using Cockcroft & Gault equation) > 45 mL/min, within 14 days of registrationXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimationXx_NEWLINE_xXSerum creatinine (Scr) =< 1.5mg/dl; if the Scr > 1.5, patients may still be eligible if the calculated glomerular filtration rate (GFR) (Cockroft-Gault) is >= 40ml/minuteXx_NEWLINE_xXEnd-stage renal disease (estimated glomerular filtration rate [GFR] < 55 ml/min/body surface area [BSA]), unless the estimated creatinine clearance by Cockcroft Gault is >= 55 ml/min prior to randomizationXx_NEWLINE_xXSerum creatinine ? 1.5 X ULN OR calculated glomerular filtration rate (GFR) by Cockcroft-Gault formula ? 50 mL/minXx_NEWLINE_xXCreatinine clearance ? 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate calculationXx_NEWLINE_xXRenal function as follows: serum creatinine < 2.0 mg/dL (176.84 umol/L) and estimated glomerular filtration rate > 30 mL/min/1.73 m2.Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 orXx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) >= 45 mL/min/1.73 m^2 as calculated using the modification of diet renal disease equationXx_NEWLINE_xXSerum creatinine >1.5 x ULN and/or creatinine clearance or estimated glomerular filtration rate <30 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or calculated glomerular filtration rate (GFR) >= 60 mL/minXx_NEWLINE_xXGlomerular Filtration Rate >= 60 mL/min (according to Modification of Diet in Renal Disease [MDRD] formula or Cockroft & Gault formula)Xx_NEWLINE_xXPulmonary function: a. Pulse oximetry with a baseline O2 saturation of ? 85% b. Diffusing capacity of the lung for carbon monoxide (DLCO) > 40% (corrected for hemoglobin) d. Renal function: Serum creatinine ? 1.5 x the upper limit of normal for age as per local laboratory and 24 hour urine creatinine clearance >70 mL/min; or GFR > 70 mL/min/1.73 m2 by radionuclide Glomerular Filtration Rate (GFR). e. Hepatic function:Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or calculated glomerular filtration rate (GFR) >= 50 mL/minXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 ORXx_NEWLINE_xXestimated creatinine clearance (CrCl, by Cockcroft-Gault formula) or estimated glomerular filtration rate (eGFR) ? 30 mL/min/1.73 m2Xx_NEWLINE_xXSubject has any of following laboratory abnormalities: WBC < 3000/uL; ANC < 1500/uL; Hemoglobin < 8 g/dL; Estimated glomerular filtration rate < 30 mL/min/1.73 m2; ALT > 3 x ULN ; Bilirubin > 1.5 x ULNXx_NEWLINE_xXMeasured creatinine clearance > 70 ml/min/1.73 m^2 or normal radioisotope glomerular filtration rate (GFR)Xx_NEWLINE_xXCreatinine clearance or radioisotope Glomerular Filtration Rate ? 70millileters/minute/1.73 meters2 or a normal serum creatinine based on age/genderXx_NEWLINE_xXPatients with pulmonary, cardiac, hepatic or renal impairment that would limit their ability to receive cytoreductive therapy and compromise their survival; this should include patients with any of the following:\r\n* Severe pulmonary dysfunction associated with a carbon monoxide diffusing capacity (DLCO) (corrected for hemoglobin) < 60%, or requires supplemental oxygen\r\n* Uncontrolled malignant arrhythmias, or clinical evidence of congestive heart failure (New York class III-IV) or ejection fraction < 50%\r\n* Renal disease with estimated glomerular filtration rate (GFR) by creatinine clearance or iothalamate clearance < 50 ml/min/1.73 m^2 body surface area\r\n* Serum glutamate pyruvate transaminase (SGPT)/aspartate aminotransferase (AST) > 3 times normal or direct bilirubin greater than 2.5 mg/dL on two repeated testsXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or calculated glomerular filtration rate (GFR) >= 60 mL/minXx_NEWLINE_xXSerum creatinine ? 1.5 mg/dL (or glomerular filtration rate ? 60 ml/min as determined by the Cockcroft-Gault equation)Xx_NEWLINE_xXGlomerular filtration rate (GFR) greater than or equal to 40 ml/min using the Cockcroft-Gault formula or serum creatinine less than or equal to 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXEstimated glomerular filtration rate (EGFR) >= 30 ml/minXx_NEWLINE_xXINCLUSION - TREATMENT: Estimated glomerular filtration rate (GFR) > 60 mL/minXx_NEWLINE_xXif serum creatinine > 3mg/dL, estimated glomerular filtration rate (GFR) ? 20 mL/minXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 orXx_NEWLINE_xXSerum creatinine ?2.0 mg/dL or eGFR (estimated Glomerular Filtration Rate) < 40 mL/min.Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 orXx_NEWLINE_xXSerum creatinine within normal range, or if serum creatinine outside normal range, then glomerular filtration rate (GFR) > 40 mL/min/1.73m2 as calculated with the Cockcroft-Gault equation with adjustment if total body weight is ? 125% of ideal body weight.Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL OR calculated glomerular filtration rate (GFR) >= 60 mL/minXx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) of > 45 mls/min using Cockcroft and Gault formulaXx_NEWLINE_xXRenal: For patients > 13.0 years of age at the time of enrollment: estimated creatinine clearance > 50 mL/minute (using the Cockcroft-Gault formula and actual body weight). For patients < 13.0 years of age at enrollment: Glomerular Filtration Rate (GFR) estimated by the updated Schwartz formula ? 90 mL/min/1.73 m2. If the estimated GFR is < 90 mL/min/1.73 m^2, then renal function must be measured by 24-hour creatinine clearance or nuclear GFR, and must be > 50 mL/min/1.73 m^2.Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) > 45 mL/min (if eGFR is not included on the clinical lab report,\r\nthe chronic kidney disease epidemiology [CKD-EPI] creatinine calculator may be used)Xx_NEWLINE_xXTREATMENT INCLUSION: Estimated glomerular filtration rate (GFR) > 70 mL/minXx_NEWLINE_xXAdequate renal function (within normal limits or calculated glomerular filtration rate >50)Xx_NEWLINE_xXGlomerular filtration rate (GFR) ? 30 mL/min/1.73 m2 using the MDRD-4 variable formulaXx_NEWLINE_xXGlomerular filtration rate > 40ml/min/1.73m^2 as estimated by the Cockcroft-Gault formula or creatinine clearance > 50ml/min as determined by 24-hour urine collectionXx_NEWLINE_xXEstimated glomerular filtration rate (GFR by Cockroft-Gault equation OR 24 hour urine collection >= 60 ml/minXx_NEWLINE_xXSerum creatinine: < 1.5 mg/dL or calculated glomerular filtration rate (GFR) >= 75 cc/min; creatinine clearance (CrCl) by Cockcroft Gault will be used to estimate GFRXx_NEWLINE_xXCreatinine =< 1.5 x IULN or glomerular filtration rate of >= 60 mL/minXx_NEWLINE_xXImpaired kidney function requiring dialysis or glomerular filtration rate (GFR) < 40mL/min (estimated or calculated)Xx_NEWLINE_xXGlomerular filtration rate ? 60 ml/minXx_NEWLINE_xXRenal failure; exception: if GFR (glomerular filtration rate) is > 20%, a patient with renal failure can be included in the studyXx_NEWLINE_xXGlomerular filtration rate (GFR) >= 60 ml/min/1.73 m^2 according to the Modified Diet in Renal Disease (MDRD) abbreviated formulaXx_NEWLINE_xXCreatinine =< 1.5 X ULN and estimated glomerular filtration rate (GFR) (eGFR) >= 60 ml/minXx_NEWLINE_xXCreatinine < 2.0 x ULN or estimated Glomerular Filtration Rate GFR [Cockcroft-Gault] > 30 mL/minXx_NEWLINE_xXCalculated creatinine clearance >= 30 mL/min by the modified Cockcroft and Gault formula OR glomerular filtration rate >= 30 mL/min/body surface area (BSA) by Modification of Diet in Renal Disease or Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulaXx_NEWLINE_xXEstimated glomerular filtration rate (GFR) > 50 mL/minXx_NEWLINE_xXGlomerular filtration rate (GFR) ? 30 mL/min/1.73 m2 according to the modified diet in renal disease (MDRD) abbreviated formulaXx_NEWLINE_xXCalculated or measured glomerular filtration rate (GFR) < 30 ml/min, dialysis requirement, or prior renal transplantXx_NEWLINE_xXGlomerular filtration rate (GFR), calculated via I-125 iothalamate clearance, 24-hour creatinine clearance, or Schwartz formula, >= 70 mL/min or >= 50 mL/min/1.73 m^2 done within 4 weeks prior to study entryXx_NEWLINE_xXCreatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR) >= 60 ml/min; CrCl will be calculated by Cockcroft-Gault method; eGFR will be calculated by either of the following well established formulas: modification of diet in renal disease (MDRD) or the chronic kidney disease (CKD)-epidemiology collaboration (EPI) (institutional standard) equations; if calculated CrCl/eGFR is < 60 mL/min, patient will have a 24 hr urine collection to measure CrCl; the measured CrCl must also be >= 60 ml/minXx_NEWLINE_xXCreatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation.Xx_NEWLINE_xXTREATMENT WITH SJCAR19: Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 50 ml/min/1.73 m^2 (GFR >= 40 ml/min/1.73 m^2 if < 2 years of age)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70mL/min/1.73 m^2.Xx_NEWLINE_xXCreatinine: glomerular filtration rate (GFR) > 30 as calculated by modification of diet in renal disease (MDRD) equationXx_NEWLINE_xXWithin 28 days prior to treatment start: Serum creatinine glomerular filtration rate (GFR) > 45 mL/minXx_NEWLINE_xXGlomerular filtration rate (GFR) >= 45 mL/minXx_NEWLINE_xXSTUDY TREATMENT: Creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation within 14 days prior to the first study treatment.Xx_NEWLINE_xXAdequate renal function as evidenced by serum creatinine ?2.0 × ULN or creatinine clearance 40 mL/min based on the Cockcroft-Gault glomerular filtration rate (GFR)Xx_NEWLINE_xXPediatric population (patients < 18 years): creatinine within normal limits or calculated creatinine clearance >= 90 ml/min/1.73 m^2 as calculated by the Schwartz formula for estimated glomerular filtration rate (GFR)Xx_NEWLINE_xXAdult population (patients >= 18 years): Serum creatinine =< 1.0 mg/dL; if serum creatinine > 1.0 mg/dL, then the estimated glomerular filtration rate (GFR) must be > 60 mL/min/1.73 m^2 as calculated by the Modification of Diet in Renal Disease equationXx_NEWLINE_xXSerum creatinine < 2.0 ULN OR an estimated glomerular filtration rate ? 30 mL/minute using the Cockroft-Gault formula.Xx_NEWLINE_xXWithin two weeks prior to enrollment: Serum creatinine which is less than 1.5 times the upper limit of institutional normal for age or glomerular filtration rate (GFR) > 70 ml/min/1.73m^2Xx_NEWLINE_xXCreatinine clearance or glomerular filtration rate >= 70 ml/min/1.73 m^2 (calculated or measured as appropriate for age and level of concern by treating medical doctor [MD])Xx_NEWLINE_xXGlomerular filtration rate (GFR) greater than or equal to 40 ml/min using the Cockcroft-Gault formula or serum creatinine less than or equal to 1.5 x ULNXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft?Gault glomerular filtration rate estimationXx_NEWLINE_xXGlomerular filtration rate (GFR) greater than or equal to 40 ml/min using the Cockcroft-Gault formula or serum creatinine less than or equal to 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation.Xx_NEWLINE_xXCreatinine < 1.5 x ULN or estimated glomerular filtration rate (GFR) >= 50 ml/min by Cockcroft-GaultXx_NEWLINE_xXGlomerular filtration rate (either estimated or calculated from 24-hour urine collection) ? 45 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x the upper limit of normal for age as per local laboratory and 24 hour urine creatinine clearance > 70 mL/min/1.73 m^2 OR glomerular filtration rate (GFR) > 70 mL/min/1.73 m^2 by radionuclide GFRXx_NEWLINE_xXGlomerular filtration rate (GFR) > 60 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN OR creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation, obtained within 7 days prior to first study treatmentXx_NEWLINE_xXWithin 7-10 days of study drug administration: Renal function\r\n* Adults (age 18 or >): Serum creatinine =< 1.2 mg/dl; if serum creatinine is > 1.2 mg/dL, nuclear glomerular filtration rate (GFR) will be measured\r\n** GFR will need to be >= 80 ml/min/1.73 m^2 for subjects =< 40 years old\r\n** >= 70 ml/min/1.73 m^2 for subjects between 41-50\r\n** >= 60 ml/min/1.73 m^2 for subjects between 51-60\r\n** >= 50 ml/min/1.73 m^2 for subjects > 60 years old\r\n* Children (age < 18): nuclear GFR >= 80 mL/min/1.73 m^2Xx_NEWLINE_xXGFR ?45 mL/min/1.73 m2 calculated by CKD-EPIXx_NEWLINE_xXSubject has adequate renal function defined as: Adequate real function with Sserum creatinine based on age/gender calculated using the Schwartz formula as described in protocol, or a 24-hour creatinine clearance or radioisotope glomerular filtration rate (GFR) (radioisotope or iothalamate) ? 70 mL/min/1.73 m2.Xx_NEWLINE_xXA serum creatinine based on age/gender, derived from the Schwartz formula for estimating glomerular filtration rate (GFR), per protocol-specified criteria.Xx_NEWLINE_xXHaving an estimated glomerular filtration rate (GFR) < 40 ml/min/1.73 m^2.Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) >= 50 mL/min/1.73m^2 per current institutional calculation formula (within 14 days of study registration)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 60 ml/min/1.73 m^2, ORXx_NEWLINE_xXSerum creatinine < 3.0 mg/dl or if elevated, a calculated glomerular filtration rate (GFR) of > 30 mL/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine > 1.5 x the ULN or an estimated glomerular filtration rate (eGFR) calculated using the Modification of Diet in Renal Disease (MDRD) equation of < 45 mL/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimationXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or estimated glomerular filtration rate (GFR) >= 50 mL/min/m^2Xx_NEWLINE_xXObtained within 14 days prior to the first study treatment (cycle 1, day 1): serum creatinine =< 1.5 x ULN or creatinine clearance =< 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimationXx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal ORXx_NEWLINE_xXEstimated creatinine clearance or GFR (glomerular filtration rate) >= 50 mL/minXx_NEWLINE_xXIneligible for cisplatin as defined by presence of one or more of the following:\r\n* Impaired renal function (glomerular filtration rate [GFR] >= 30 but =< 60 cc/min); GFR should be assessed by direct measurement (i.e. creatinine clearance or ethylenediaminetetra-acetate) or, if not available, by calculation from serum/plasma creatinine by Cockroft-Gault equation\r\n* Grade >= 2 hearing loss (measured by loss of > 25 dB at two contiguous frequencies in at least one ear)\r\n* Grade >= 2 peripheral neuropathy\r\n* ECOG performance status of 2\r\n* Solitary kidneyXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL OR calculated glomerular filtration rate (GFR) >= 60 mL/minXx_NEWLINE_xXPatients will not be eligible if they present with moderate to severe decrease in creatinine clearance (estimated glomerular filtration rate [eGFR] < 45 mL/min/1.73m2)Xx_NEWLINE_xXGlomerular filtration rate (GFR) > 50 ml/min/1.73 m^2 or serum creatinine =< 2.5 x upper limit of normal (ULN) for ageXx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) > 45 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine < 1.5 mg/dl OR estimated glomerular filtration rate (eGFR) (creatinine clearance) >= 60 mL/min/1.73 m^2Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) >= 50 mL/min/1.73m^2 per current institutional calculation formulaXx_NEWLINE_xXPatients with estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine =< 2 mg/dL and estimated glomerular filtration rate or creatinine clearance >= 20 ml/minXx_NEWLINE_xXEstimated creatinine clearance >= 30 mL/min (24 hour measured glomerular filtration rate [GFR] or modified Cockcroft Gault)Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) >= 60 mL/min/1.73 m^2Xx_NEWLINE_xXGlomerular Filtration Rate (GFR) <40 ml/minXx_NEWLINE_xXModification of diet in renal disease (MDRD) calculated glomerular filtration rate (GFR) < 30 mL/minXx_NEWLINE_xXSevere renal dysfunction (estimated glomerular filtration rate at the Screening visit; calculated by the central laboratory) <30 mL/min/1.73 m^2 or on chronic dialysisXx_NEWLINE_xXWithin 14 days prior to the first study treatment (cycle 1, day 1): Serum creatinine =< 1.25 x ULN or creatinine clearance >= 60 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimationXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimationXx_NEWLINE_xXFULL STUDY INCLUSION CRITERIA: Glomerular filtration rate (GFR) >= 30 mL/min/1.73 m^2 according to the Modification of Diet in Renal Disease (MDRD) abbreviated formulaXx_NEWLINE_xXInadequate renal function at screening as demonstrated by creatinine clearance < 50 mL/min or glomerular filtration rate < 50 mL/min/1.73 m^2Xx_NEWLINE_xXMaximum serum creatinine 1.5 mg/dL OR a creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70ml/min/1.73 m^2Xx_NEWLINE_xXCreatinine ? 1.5 x upper limit of normal (ULN), or calculated glomerular filtration rate (GFR) > 40 mL/min (Cockcroft-Gault) if creatinine > 1.5x ULNXx_NEWLINE_xXSerum creatinine level =< 1.5 mg/dL or estimated glomerular filtration rate >= 50 mL/minXx_NEWLINE_xXSerum creatinine ? 1.5 x ULN or creatinine clearance ? 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation within 14 days prior to the first study treatment (cycle 1, day 1)Xx_NEWLINE_xXCreatinine greater than > 2 x ULN for age or creatinine clearance/glomerular filtration rate (GFR) < 40 ml/min/1.73 m^2Xx_NEWLINE_xXGlomerular filtration rate (GFR) >= 45 mL/minXx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) of at least 50 ml/min; the Cockcroft Gault formula will be utilized to determine eGFR when blood urea nitrogen (BUN) and creatinine testing are performed at baseline. The combination of eGFR serum creatinine and BUN will be used to evaluate patient's renal function for safety assurance.Xx_NEWLINE_xXCreatinine > 1.5 x ULN or glomerular filtration rate (GFR) < 45 mL/minXx_NEWLINE_xXGlomerular filtration rate (GFR) < 50 mL/min, as assessed using the standard methodology at the investigating center (i.e. Cockroft-Gault), or serum creatinine > 1.5 x ULNXx_NEWLINE_xXAbnormal kidney function (glomerular filtration rate GFR < 45 mL/min)Xx_NEWLINE_xXFor patients >= 1.0 year of age but < 13.0 years of age at the time of enrollment: glomerular filtration rate (GFR) estimated by the updated Schwartz formula >= 90 mL/min/1.73 m^2; if the estimated GFR is < 90 mL/min/1.73 m^2, then renal function must be measured by 24-hour creatinine clearance or nuclear GFR, and must be > 50 mL/min/1.73 m^2Xx_NEWLINE_xXGlomerular filtration rate (GFR) adequate for intravenous (IV) contrast delivery for imagingXx_NEWLINE_xXCreatinine clearance (CrCl) or glomerular filtration rate (GFR) >= 50 ml/min/1.73 m^2Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) of at least 50ml/min using the Cockcroft Gault formula will be determined at base line when testing of BUN and creatinine is performed. The combination of eGFR serum creatinine and BUN will be used to evaluate renal function and assure the safety of this patient function.Xx_NEWLINE_xXCreatinine < 2 mg/dl (or a glomerular filtration rate > 60)Xx_NEWLINE_xXEstimated GFR < 40 ml/minXx_NEWLINE_xXSerum creatinine within normal range, or if serum creatinine outside normal range, then renal function (measured or estimated creatinine clearance or glomerular filtration rate [GFR]) > 40mL/min/1.73 m^2Xx_NEWLINE_xXGlomerular filtration rate (GFR) >= 45 mL/minXx_NEWLINE_xXWithin 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR estimated glomerular filtration rate (GFR) per Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULNXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dl or glomerular filtration rate > 50 ml/minXx_NEWLINE_xXCreatinine =< 2.0 mg/dl (adults) and estimated glomerular filtration rate (GFR) >= 40 mL/min (pediatrics); adults with a creatinine > 1.2 mg/dl or a history of renal dysfunction must have estimated glomerular filtration rate (GFR) > 40 mL/minXx_NEWLINE_xXEstimated glomerular filtration rate (GFR) by Modification of Diet in Renal Disease (MDRD) formula > 40 mL/min/1.73 m^2Xx_NEWLINE_xXGlomerular filtration rate (GFR) < 30 ml/min/1.73 m^2 (if receiving contrast for MRI)Xx_NEWLINE_xXCreatinine =< 1.5 x IULN OR glomerular filtration rate (GFR) of >= 50 mL/minXx_NEWLINE_xXCreatinine clearance or glomerular filtration rate (GFR) > 60 mL/min/1.73 m^2; if a creatinine clearance is performed at end induction and the result is < 100 ml/min/1.73 m^2, a GFR must then be performed using a nuclear blood sampling method or iothalamate clearance method; camera method is NOT allowed as measure of GFR prior to or during consolidation therapy for patients with GFR or creatinine clearance of < 100 ml/min/1.73 m^2Xx_NEWLINE_xXKidney: estimated glomerular filtration rate (Cockcroft-Gault) ? 50 mL/min.Xx_NEWLINE_xXWithin 14 days prior to registration: Serum creatinine < 1.5 X institutional ULN mg/dL OR estimated glomerular filtration rate (eGFR) >= 50 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimationXx_NEWLINE_xXAn estimated glomerular filtration rate (eGFR) calculated using the Modification of Diet in Renal Disease (MDRD) equation of at least 45 mL/min/1.73 m^2Xx_NEWLINE_xXWithin 3 months of registration: Glomerular filtration rate (GFR) >= 45 mL/min; Cockcroft-Gault formula will be used to calculate creatinine clearanceXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 60 ml/min/1.73m^2Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) of at least 50 mL/minXx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) (chronic kidney disease [CKD]-epidemiology collaboration [EPI]) >= 50 mL/min/1.73 m^2Xx_NEWLINE_xXGlomerular filtration rate (GFR) > 60 as defined by the Modification of Diet in Renal Disease (MDRD) formulaXx_NEWLINE_xXSerum creatinine =< 2 x ULN or glomerular filtration rate (GFR) >= 50Xx_NEWLINE_xXSerum creatinine concentration =< 3 x the institutional upper limit of normal (ULN) or creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2Xx_NEWLINE_xXTREATMENT: Glomerular filtration rate (GFR) > 30 mL/min (calculated by the Cockcroft-Gault, Modification of Diet in Renal Disease [MDRD] study, or Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] creatinine equations, or equivalent)Xx_NEWLINE_xXSerum creatinine based on age or creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/ml/min/1.73 m^2Xx_NEWLINE_xXGlomerular filtration rate (GFR) > 50 ml/min/1.72 m^2 or creatinine < 2 g/dL, values =< 2 weeksXx_NEWLINE_xXEstimated or actual glomerular filtration rate (GFR) > 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal; GFR should be corrected for body surface area (BSA)Xx_NEWLINE_xXELIGIBILITY CRITERIA FOR T-CELL PRODUCT INFUSION: Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a normal serum creatinine based on age/genderXx_NEWLINE_xXCreatinine < 1.5 mg/dl or glomerular filtration rate > 50 ml/minXx_NEWLINE_xXFor patients who agree to participate in PET/MR imaging:\r\n* Renal insufficiency (glomerular filtration rate [GFR] < 30 mL/min/1.73 m^2) measured within the past 60 days which precludes safe administration of the contrast agent\r\n* On dialysis\r\n* Prior allergic reaction to gadolinium-based MR contrast agentsXx_NEWLINE_xXCreatinine =< 1.5 X institutional upper limit of normal or estimated glomerular filtration rate < 45 mL/min/1.73 m^2Xx_NEWLINE_xXEstimated glomerular filtration rate (GFR) > 30 ml/minXx_NEWLINE_xXSerum creatinine within normal range for age, or if serum creatinine outside normal range for age, then renal function (creatinine clearance or glomerular filtration rate [GFR]) > 40 mL/min/1.73m^2Xx_NEWLINE_xXGlomerular filtration rate (GFR) > 59Xx_NEWLINE_xXCreatinine < 2 mg/dl (or a glomerular filtration rate > 60 mL/min)Xx_NEWLINE_xXAdequate renal function with glomerular filtration rate equal to or greater than 30 ml/min/1.73 m2Xx_NEWLINE_xXSerum creatinine > 1.8 mg/dL OR glomerular filtration rate (GFR) < 30 mL/minXx_NEWLINE_xXRenal (glomerular filtration rate [GFR] > 40) contraindications for high dose chemotherapyXx_NEWLINE_xXSerum creatinine > 1.5 x the upper limit of normal for age, or calculated creatinine clearance or nuclear glomerular filtration rate (GFR) < 70 ml/min/1.73 m^2Xx_NEWLINE_xXGlomerular filtration rate (GFR) >= 45 mL/minXx_NEWLINE_xXCreatinine clearance or glomerular filtration rate ?30 mL/min as estimated by the Cockroft-Gault (C-G) or other medically acceptable formulas, such as MDRD (Modification of Diet in Renal Disease) or CKD-EPI (the Chronic Kidney Disease Epidemiology Collaboration).Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) > 70 ml/min/1.73 m^2 or normal serum creatinine for patient’s age and genderXx_NEWLINE_xXGlomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2Xx_NEWLINE_xXAdequate renal function with creatinine (Cre) =< 1.5; if greater, then glomerular filtration rate (GFR) > 60 mL/min/1.73 m^2 as calculated by the Modification of Diet in Renal Disease equationXx_NEWLINE_xXCreatinine clearance or glomerular filtration rate (GFR) >= 60 ml/minXx_NEWLINE_xXSerum creatinine within normal range for age, or if serum creatinine outside normal range for age, then renal function (creatinine clearance or glomerular filtration rate [GFR]) > 40 mL/min/1.73m^2Xx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) for age or creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2Xx_NEWLINE_xXSerum Creatinine <~ 1.5 x normal, or creatinine clearance of 70 ml/min/1.73 m^2 or an equivalent glomerular filtration rate (GFR) as determined by the institutional normal rangeXx_NEWLINE_xXGlomerular filtration rate > 60 ml/min/1.73 m^2Xx_NEWLINE_xXEither serum creatinine ? 1.5 x ULN or estimated glomerular filtration rate ? 45 mL/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine < 1.5 x upper limit normal (ULN) or estimated glomerular filtration rate (GFR) > 50 mL/min based upon Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation. Patients with estimated GFR between 50 - 60 mL/min at baseline will require a 99mTc-DTPA GFR test and only patients with non-obstructive pathology will be included in the study.Xx_NEWLINE_xXA serum creatinine based on age/gender, derived from the Schwartz formula for estimating glomerular filtration rate (GFR)Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) > 40 mL per 1.73 m*2Xx_NEWLINE_xXAdequate renal function defined as normal serum creatinine for the participant's age or creatinine clearance or radioisotope glomerular filtration rate (GFR) 70 milliliter per minute per 1.73 square meter (mL/min/1.73 m^2) at Cycle 1 Day 1 pre-dosingXx_NEWLINE_xXRenal-calculated or measured glomerular filtration rate (GFR) < 40 ml/min, dialysis requirement, or prior renal transplantXx_NEWLINE_xXScreening laboratory analyses shows any of the following abnormal laboratory results: Estimated Glomerular filtration (eGFR) rate < 30 mL/minXx_NEWLINE_xXeGFR > 45 mL/minXx_NEWLINE_xXGlomerular filtration rate (GFR) at Screening < 40 milliliter (mL)/minute (min)Xx_NEWLINE_xXEstimated glomerular filtration rate (GFR) (eGFR) >= 60 ml/minXx_NEWLINE_xXGlomerular filtration rate (GFR) ?30 ml/min/1.73 m2 (assessed using the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation)Xx_NEWLINE_xXGlomerular filtration rate (GFR) ? 30 mL/min/1.73 m2 according to the Modification of Diet in Renal Disease (MDRD) formula.Xx_NEWLINE_xXSerum creatinine ?1.5 mg/dL or estimated glomerular filtration rate (eGFR) ?60 mL/min/1.73 m2Xx_NEWLINE_xXWithin 14 days of first dose of study drug: Serum creatinine =< 1.5 x ULN or estimated glomerular filtration rate (GFR) >= 45 mL/min using the Cockcroft Gault formulaXx_NEWLINE_xXAdequate renal function (estimated glomerular filtration rate [GFR] > 40mL/min)Xx_NEWLINE_xXEstimated creatinine clearance of >= 60 ml/min according to the Cockcroft-Gault formula, unless calculated to be < 60 ml/min or borderline in which case glomerular filtration rate (GFR) should be formally measured, e.g. with edetic acid (EDTA) scanXx_NEWLINE_xXWithin 14 days prior to the first study treatment (cycle 1, day 1): Serum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation.Xx_NEWLINE_xXCreatinine ? 2 x ULN OR creatinine clearance > 30 mL/min based on the Cockroft-Gault glomerular filtration rate (GFR) estimation within 14 days prior to registrationXx_NEWLINE_xXGlomerular filtration rate ? 45 ml/min based on Cockcroft-Gault equationXx_NEWLINE_xXENROLLMENT: Creatinine clearance >= 60 mL/min/1.73m^2 (calculated by 24 hour [h] urine collection or nuclear glomerular filtration rate [GFR] scan if 24 h collection is not possible) or a serum creatinine based on age and gender as follows: age 1 month to < 6 months, maximum serum creatinine (mg/dL) male 0.4, female 0.4; 6 months to < 1 year, 0.5, 0.5; 1 to < 2 years, 0.6, 0.6; 2 to < 6 years, 0.8, 0.8; 6 to < 10 years, 1, 1; 10 to < 13 years, 1.2, 1.2; 13 to < 16 years, 1.5, 1.4; >= 16 years, 1.7, 1.4.Xx_NEWLINE_xXCreatinine < 2.0 mg/dl for adults or glomerular filtration rate > 50 ml/min for childrenXx_NEWLINE_xXWithin 14 days of study registration (30 days for pulmonary and cardiac): estimated glomerular filtration rate (GFR) >= 40 mL/min/1.73m^2Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or estimated glomerular filtration rate (GFR) >= 45 mL/min using Cockcroft Gault formulaXx_NEWLINE_xXRenal impairment defined as estimated glomerular filtration rate (EGFR) < 30Xx_NEWLINE_xXCreatinine within institutional normal limits or glomerular filtration rate >= 30 mL/min/1.73 m^2 by chronic kidney disease (CKD) epidemiology collaboration (EPI) equationXx_NEWLINE_xXCreatinine within institutional normal limits or Glomerular filtration rate (GFR) > 50 mL/min/m^2 (calculated by the Cockcroft-Gault equation), calculated as follows:\r\n* For males = ((140 – age[years]) x (body weight [kg]))/((72) x (serum creatinine [mg/dL]))\r\n* For females = 0.85 x male valueXx_NEWLINE_xXGlomerular filtration rate (GFR) >= 30 ml/min/1.73 m^2 according to the Modified Diet in Renal Disease (MDRD) abbreviated formulaXx_NEWLINE_xXCreatinine within institutional normal limits or glomerular filtration rate (GFR) > 60 mL/min/m^2 (calculated by the Cockcroft-Gault equation)Xx_NEWLINE_xXCreatinine clearance >= 50 mL/min by either measured (using the Cockcroft-Gault, Modification of Diet in Renal Disease [MDRD] or Chronic Kidney Disease Epidemiology [CKD-EPI] formula) or calculated clearance (i.e. glomerular filtration rate [GFR])Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) >= 50 ml/min/1.73 m^2 using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, obtained within 14 days prior to the first study treatment (cycle 1, day 1)Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) > 30 (milliliter per minute (mL/min) /1.73 square meter (m^2) as assessed by Modification of Diet in Renal Disease (MDRD) formula for subjects >= 18 years of age or Schwartz formula for subjects less than (<) 18 years of age.Xx_NEWLINE_xXCreatinine clearance or glomerular filtration rate ?30 mL/min estimated by the Cockroft-Gault (C-G) or other medically acceptable formulas such as MDRD (Modification of Diet in Renal Disease) or CKD-EPI (the Chronic Kidney Disease Epidemiology Collaboration).Xx_NEWLINE_xXAdequate renal function: Estimated glomerular filtration rate ? 30 mL/minute using the Cockroft-Gault formula or: a serum creatinine based on age/gender as outlined in the protocolXx_NEWLINE_xXPatients with a serum creatinine > 1 are eligible if they have a calculated glomerular filtration rate (GFR) of >= 60 ml/min (i.e. class I or class II chronic kidney disease ) using the Modification of Diet in Renal Disease (MDRD) formula\r\n* Note: Daily creatinine and MDRD formula are only for the 1st induction cycleXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 orXx_NEWLINE_xXGlomerular filtration rate (GFR) or creatinine clearance (CrCl) (24 hour urine) greater than 30 ml/min corrected for body surface areaXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 orXx_NEWLINE_xXEstimated glomerular filtration rate (GFR) ?30 mL/min as assessed by CKD-epi, MDRD or the Cockcroft-Gault EquationXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal or a creatinine clearance or glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2Xx_NEWLINE_xXGlomerular filtration rate (GFR) greater than or equal to 40 ml/min using the Cockcroft-Gault formula or serum creatinine less than or equal to 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 orXx_NEWLINE_xXCreatinine clearance estimated glomerular filtration rate (GFR) >= 30 mL/min/1.73 m^2 (Cockcroft-Gault)Xx_NEWLINE_xXEstimated glomerular filtration rate (GFR) of >= 50 ml/min (based on the Fairview Laboratories formula at time of screening)Xx_NEWLINE_xXWithin 14 days of registration: Serum creatinine =< 1.8 mg/dL; for patients with a creatinine > 1.5 mg/dL or a history of renal dysfunction, an estimated glomerular filtration rate >= 35 mL/min/1.73 m^2 is requiredXx_NEWLINE_xXPatients with severe renal disease (i.e. measured or estimated creatinine clearance or radioisotope glomerular filtration rate [GFR] =< 70 ml/min/1.73 m^2)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate >= 60 mL/minXx_NEWLINE_xXCreatinine: =< 3 mg/dl OR if serum creatinine > 3 mg/dl, estimated glomerular filtration rate (GFR) > 30 mL/min/1.73 m^2Xx_NEWLINE_xXSubjects must have adequate kidney function, with serum creatinine < 1.5 x upper limit of normal (ULN) or calculated glomerular filtration rate (GFR) of > 45/mL/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimationXx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) greater than or equal to 60 ml/min/1.73 m^2Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 orXx_NEWLINE_xXSerum creatinine =< 1.2 mg/dL or serum creatinine > 1.2 mg/dL and an estimated glomerular filtration rate (GFR) > 60 mL/min/1.73 m^2 as calculated by the modification of diet in renal disease equationXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a maximum serum creatinine (mg/dL) based on age/gender as follows:\r\n* 1 to < 2 years: 0.6 \r\n* 2 to < 6 years: 0.8 \r\n* 6 to < 10 years: 1 \r\n* 10 to < 13 years: 1.2 \r\n* 13 to < 16 years: 1.5 for males, 1.4 for females\r\n* >= 16 years: 1.7 for males, 1.4 for femalesXx_NEWLINE_xXEstimated glomerular filtration rate (GFR) (calculated using Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation) >= 30 mL/min/1.73 sq.m.Xx_NEWLINE_xXCreatinine < 2 mg/dl; glomerular filtration rate (GFR) > 50 mL/min (Cockroft and Gault formula)Xx_NEWLINE_xXEstimated or actual glomerular filtration rate (GFR*) > 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal\r\n* GFR should be corrected for body surface area (BSA)Xx_NEWLINE_xXSerum creatinine ? 1.5 x ULN or an estimated glomerular filtration rate of > 50 mL/min as calculated by the Modification of Diet in Renal Disease equation.Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or estimated glomerular filtration rate (GFR) (by Cockcroft-Gault) >= 50 mL/min or 12 or 24 hour urine creatinine clearance >= 50 mL/min, unless renal insufficiency is due to tumoral ureteral obstruction in which case eligibility will be determined by the national principal investigator (or national co-PI or MSKCC co-PI if the national PI is unavailable) with notification of the MSKCC Institutional Review Board (IRB)Xx_NEWLINE_xXSerum creatinine ?1.5×upper limit of normal (ULN), or glomerular filtration rate >25 mL/min, as calculated with the Cockcroft-Gault formula.Xx_NEWLINE_xXCreatinine clearance calculated using the Schwartz formula, or radioisotope glomerular filtration rate (GFR) > 70 mL/min/1.73 m2.Xx_NEWLINE_xXSubjects must have adequate renal function as evidenced by a serum creatinine ?2.0 × ULN or creatinine clearance >40mL/min based on Cockroft-Gault glomerular filtration rate (GFR)Xx_NEWLINE_xXPatient must have adequate renal function as evidenced by: Serum creatinine ?2.0 × ULN or Creatinine clearance >40 mL/min based on the Cockroft-Gault glomerular filtration rate (GFR) estimated: (140-Age) x (weight in kg) x (0.85 if female)/72 x serum creatinineXx_NEWLINE_xXRenal function defined as (Calculated creatinine clearance or radioisotope Glomerular Filtration Rate (GFR) > 60 mL/min/1.73 m2 OR serum creatinine based on age/genderXx_NEWLINE_xXEstimated Glomerular Filtration Rate (eGFR) ? 60 mL/min/1.73 m2Xx_NEWLINE_xXRenal function estimated glomerular filtration rate (eGFR) > 30 mL/min via calculated creatinine clearanceXx_NEWLINE_xXeGFR ? 50 mL/min/1.73 m2Xx_NEWLINE_xXGlomerular filtration rate (GFR) must be greater than or equal to 30 mL/min/1.73 m2 according to the Modified Diet in Renal Disease (MDRD) abbreviated formula.Xx_NEWLINE_xXGlomerular Filtration Rate (GFR) > 40mL (milliliter)/min; Creatinine ? 1.5 x ULN (Upper limit of Normal)Xx_NEWLINE_xXCreatinine clearance estimated (est.) glomerular filtration rate (GFR) >= 30 mL/min/1.73 m^2 (Cockcroft-Gault)Xx_NEWLINE_xXGlomerular filtration rate (GFR) > 30 mL/min (by standard Cockcroft and Gault formula or measured via 24 hour urine collection)Xx_NEWLINE_xXSerum creatinine =< 2 mg/dL (or glomerular filtration rate >= 40 ml/min)Xx_NEWLINE_xXSerum creatinine =< 1.2 mg/dL for subjects age 18 or >; if serum creatinine is > 1.2 mg/dL, nuclear glomerular filtration rate (GFR) will be measured; GFR will need to be >= 80 ml/min/1.73 m^2 for subjects =< 40 years old; children (age < 18): nuclear GFR >= 80 mL/min/1.73 m^2Xx_NEWLINE_xXRenal function\r\n* >= 70 ml/min/1.73 m^2 for subjects between 41-50\r\n* >= 60 ml/min/1.73 m^2 for subjects between 51-60\r\n* >= 50 ml/min/1.73 m^2 for subjects > 60 years old\r\n** Renal function criteria based on our previous experience with 90Y-DOTATOC therapy and known changes in GFR with ageXx_NEWLINE_xXGlomerular filtration rate (GFR) ? 60 mL/min/1.73 m2 according to the Modified Diet in Renal Disease (MDRD) abbreviated formula.Xx_NEWLINE_xXSerum creatinine =< 2 x ULN or glomerular filtration rate (GFR) >= 50Xx_NEWLINE_xXSerum creatinine < 1.5 x institutional Upper Limit of Normal (ULN) or an estimated glomerular filtration rate (eGFR) of > 50 ml/min as calculated by the Modification of Diet in Renal Disease (MDRD) equationXx_NEWLINE_xXCreatinine < 2 mg/dl (or a glomerular filtration rate > 60)Xx_NEWLINE_xXCalculated creatinine clearance (estimated glomerular filtration rate [eGFR]) < 60 ml/min; EGFR values can be determined by either Modification of Diet in Renal Disease (MDRD) or Cockcroft-Gault equation based on the investigator’s discretionXx_NEWLINE_xXCreatinine clearance or estimated radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 orXx_NEWLINE_xXGlomerular filtration rate (GFR) > 25 ml/min (for patients receiving cisplatin, GFR >= 60 ml/min)Xx_NEWLINE_xXCreatinine < 2 mg/dl (or a glomerular filtration rate > 60)Xx_NEWLINE_xXSerum creatinine ? 1.5 x ULN or creatinine clearance ? 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation:Xx_NEWLINE_xXEstimated glomerular filtration rate >= 60 ml/min/1.73m^2 using the chronic kidney disease (CKD)-epidemiology (EPI) equationXx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) >= 50 ml/min/1.73m^2 using the CKD-EPI equationXx_NEWLINE_xXRenal: serum creatinine (SCr) within normal range for age (see table 2.3). If SCr is outside normal range for age, creatinine clearance (CrCl) > 40 mL/min/1.73m2 must be obtained (measured by 24-hour (hr) urine specimen or nuclear glomerular filtration rate (GFR), or calculated GFR (by Cockcroft-Gault formula for those aged ? 18 years; by Original Schwartz estimate for those < 18 years))Xx_NEWLINE_xXCreatinine clearance >= 50 mL/min/1.73 m^2 (calculated by estimated glomerular filtration rate [eGFR] from EPIC)Xx_NEWLINE_xXCreatinine > 1.5 ULN or glomerular filtration rate (GFR) < 45 ml/minXx_NEWLINE_xXSerum creatinine =< 2 mg/dL (or glomerular filtration rate >= 50 ml/min as determined by the Cockcroft-Gault equation)Xx_NEWLINE_xXWithin 14 days prior to the first study treatment (cycle 1, day 1): Serum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimationXx_NEWLINE_xXCreatinine =< 1.5 times ULN for age OR a creatinine clearance or glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2; obtained =< 7 days prior to registrationXx_NEWLINE_xXCreatinine =< 1.5 or glomerular filtration rate (GFR) >= 60 mL/min/1.73m^2Xx_NEWLINE_xXAdequate renal function with estimated glomerular filtration rate (GFR) by Cockcroft Gault of greater than 40 ML per minuteXx_NEWLINE_xXOR if serum creatinine > 3 mg/dL, estimated glomerular filtration rate (GFR) ? 20 mL/minXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) (or glomerular filtration rate [GFR] >= 60 ml/min for patients with creatinine > 1.5 x ULN)Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) of at least 50 mL/minXx_NEWLINE_xXThe standard Cockcroft and Gault formula or the measured glomerular filtration rate must be used to calculate creatinine clearance (CrCl) for enrollment or dosingXx_NEWLINE_xXCalculated creatinine clearance >= 60 mL/min (Cockcroft-Gault formula) or serum creatinine (Cr) less than institution ULN (the elderly will often have < 60 glomerular filtration rate [GFR])Xx_NEWLINE_xXCreatinine < 1.5 x the ULN or glomerular filtration rate (GFR) < 45 ml/minXx_NEWLINE_xXGlomerular filtration rate (GFR) >= 30 ml/min/1.73 m^2 according to the MDRD (modified diet in renal disease) abbreviated formulaXx_NEWLINE_xXAdequate renal function defined as glomerular filtration rate ? 40 mL/min,Xx_NEWLINE_xXMaximum serum creatinine 1.5 mg/dL OR a creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2Xx_NEWLINE_xXGlomerular filtration rate (GFR) > 50 mL/minXx_NEWLINE_xXPatients with renal failure (GFR < 50 mL/min) are excludedXx_NEWLINE_xXPatients with >= grade 3 chronic kidney disease at enrollment (estimated glomerular filtration rate [eGFR] or creatinine clearance [CrCl] < 30 ml/min/1.73m^2)Xx_NEWLINE_xXSubjects must have adequate renal function as evidenced by: a. Serum creatinine ?2.0 × ULN OR b. Creatinine clearance >40 mL/min based on the Cockroft-Gault glomerular filtration rate (GFR) estimation: (140 - Age) x (weight in kg) x (0.85 if female)/72 x serum creatinineXx_NEWLINE_xXGlomerular filtration rate ? 50 mL/min;Xx_NEWLINE_xXGlomerular filtration rate (GFR) > 40 mL/minute as calculated by the Cockcroft-Gault formulaXx_NEWLINE_xXSerum creatinine ? 1.5 x institutional ULN or an estimated glomerular filtration rate (eGFR) of > 50 ml/min as calculated by the Modification of Diet in Renal Disease (MDRD) equation.Xx_NEWLINE_xXSubjects with end stage renal function (creatinine clearance [CrCl] < 15 mL/min or glomerular filtration rate [GFR] <15 mL/min) regardless of whether hemodialysis is requiredXx_NEWLINE_xXObtained within 14 days prior to the first study treatment (cycle 1, day 1); serum creatinine ? 1.5 x ULN or creatinine clearance ? 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimationXx_NEWLINE_xXSubjects must have adequate renal function as evidenced by: • Serum creatinine ?2.0 × ULN OR • Creatinine clearance greater than 40 mL/min based on the Cockroft-Gault glomerular filtration rate (GFR) estimation: (140 - Age) x (weight in kg) x (0.85 if female)/72 x serum creatinineXx_NEWLINE_xXCreatinine < 2.0 x ULN or creatinine clearance (estimated [est.] glomerular filtration rate [GFR] [Cockcroft-Gault]) >= 30 mL/minXx_NEWLINE_xXCreatinine =< 1.5 times upper limit of normal (ULN*) OR corrected glomerular filtration rate >= 70 ml/min\r\n* NOTE: *of institutional normsXx_NEWLINE_xXAll patients must be able to undergo MRI with and without contrast with a glomerular filtration rate (eGFR) greater than or equal to 30 mg/min/1.72 m^2Xx_NEWLINE_xXParticipants must have a creatinine < 3 mg/dl and a glomerular filtration rate (GFR) > 30 mL/min/1.73m^2Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 ORXx_NEWLINE_xXGlomerular filtration rate >/= 30 ml/min/1.73 m2 according to the Modification of diet in renal disease study equation.Xx_NEWLINE_xXSerum creatinine within normal range for age, or if serum creatinine outside normal range, then renal function (estimated glomerular filtration rate [GFR] by modification of diet in renal disease [MDRD] formula) > 40 mL/min/1.73 m^2Xx_NEWLINE_xXGlomerular filtration rate (GFR) =< 50Xx_NEWLINE_xXEstimated glomerular filtration rate (GFR) > 50 ml/minXx_NEWLINE_xXSerum creatinine < 2.0 mg/dl or glomerular filtration rate (GFR) > 40 mL/min/1.73m^2; patients with a creatinine > 1.2 mg/dl or a history of renal dysfunction must have glomerular filtration rate (GFR) > 40 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine clearance or glomerular filtration rate (GFR) greater than or equal to 50 mL/min/1.73 m^2Xx_NEWLINE_xXEstimated glomerular filtration rate >= 60 ml/min/1.73 m^2 using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equationXx_NEWLINE_xXCalculated glomerular filtration rate (GFR) > 45 mL/minXx_NEWLINE_xXAcute or chronic severe renal insufficiency (Glomerular filtration rate (GFR) <30ml/min/1.73 sq.meters)Xx_NEWLINE_xXEstimated glomerular filtration rate (GFR) must be >= 50 mL/minXx_NEWLINE_xXEstimated glomerular filtration rate (GFR) >= 50 mL/min/1.73m^2Xx_NEWLINE_xXCreatinine clearance > 60 ml/min/1.73 m^2; glomerular filtration rate (GFR) may also demonstrate adequate renal functionXx_NEWLINE_xXGlomerular filtration rate (GFR) >= 30 ml/min/1.73m^2Xx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or glomerular filtration rate (GFR) of 60 cc/ml using the formula of Cockcroft and GaultXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine which is less than 1.5 x the upper limit of institutional normal for age or glomerular filtration rate (GFR) > 70 ml/min/1.73 m^2 within two weeks prior to enrollmentXx_NEWLINE_xXSerum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation (obtained within 14 days prior to the first study treatment [course 1, day 1])Xx_NEWLINE_xXGlomerular filtration rate > 30ml/min/1.73 m2 according to the Modified Diet in Renal Disease abbreviated formula or creatinine clearance (CrCL) > 60 ml/min (Cockcroft and Gault)Xx_NEWLINE_xXSerum creatinine ? 2.0 x upper limit of normal (ULN) or an estimated glomerular filtration rate (eGFR) of > 50 mL/min as calculated by the Cockcroft Gault MethodXx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) ?25 mL/min/1.73 m2 as estimated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, or measured GFR ?25 mL/min/1.73 m2Xx_NEWLINE_xXPatients will have an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m^2Xx_NEWLINE_xXeGFR > 30 ml/min/1.73 m^2Xx_NEWLINE_xXMust have estimated glomerular filtration rate (eGFR) by Modification of Diet in Renal Disease (MDRD) formula or Cockroft-Gault formula of 50 mL/min or higherXx_NEWLINE_xXCreatinine =< 1.5 times upper limit of normal (ULN) OR glomerular filtration rate >= 70 ml/minXx_NEWLINE_xXSerum creatinine <2.0 x upper limit of normal (ULN) or estimated glomerular filtration rate of > 50 mL/min as calculated by the Cockcroft Gault MethodXx_NEWLINE_xXAlkaline phosphatase 2.5 ULN with the following exception: Patients with liver or bone inv ULN or creatinine clearance 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation: (140 age) (weight in kg) (0.85 if female) 72 (serum creatinine in mg/dL)Xx_NEWLINE_xXAdequate renal function (creatinine ? 1.5×ULN [upper limit of normal]) or glomerular filtration rate of ? 60 mL/minXx_NEWLINE_xXEstimated glomerular filtration rate ?30 mL/minuteXx_NEWLINE_xXAdequate renal function, defined as serum creatinine ?2.0 times ULN and creatinine clearance >50 mL/min or estimated glomerular filtration rate (eGFR) >50 mL/min/1.73 m^2Xx_NEWLINE_xXSubjects must have adequate kidney function, as assessed by the estimated glomerular filtration rate (eGFR) >=60 mL/min per 1.73 m*2 [Common Terminology Criteria for Adverse Events(CTCAE Grade <=1)] calculated by the Modification of Diet in Renal Disease Study Group (MDRD) formulaXx_NEWLINE_xXGlomerular filtration rate (GFR) > 30 using Cockcroft–Gault formulaXx_NEWLINE_xXCreatinine >= 1.5 x upper limit of normal (ULN) or glomerular filtration rate (GFR) < 45 ml/minXx_NEWLINE_xXAdequate renal function (creatinine ? 1.5x upper limit of normal [ULN]) and/or glomerular filtration rate (GFR) of ?50 mL/min.Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) ? 60 mL/min per 1.73 m2 according to the Modification of Diet in Renal Disease Study Group (MDRD) formula (see Section 14.6)Xx_NEWLINE_xXEstimated glomerular filtration rate (GFR) > 45 mL/min/1.73 m^2Xx_NEWLINE_xXEstimated GFR > 45 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine clearance (Cockcroft-Gault) greater than or equal to 30 mL/min or estimated (est) glomerular filtration rate (GFR) greater than or equal to 30 mL/min/1.73 m^2Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age and gender as follows:\r\n* Age >= 16 years: maximum serum creatinine (mg/dL): 1.7 for male and 1.4 for femaleXx_NEWLINE_xXGlomerular filtration rate > 60 ml/minXx_NEWLINE_xXGlomerular filtration rate>/=30 mL/min/1.73 m2 according to the Modified Diet in Renal Disease abbreviated formulaXx_NEWLINE_xXCisplatin ineligibility based on one or more of the following criteria:\r\n* Estimated glomerular filtration rate (eGFR) 30-59 ml/min/1.73^2\r\n* >= Grade 2 sensory neuropathy\r\n* >= Grade 2 hearing lossXx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL; if serum creatinine > 1.5 mg/dL, then the estimated glomerular filtrate rate (GFR) must be > 60 ml/min/1.73 m^2 as calculated by the Modification of Diet in Renal Disease equationXx_NEWLINE_xX13. Adequate renal function (creatinine ? 1.5 x ULN [upper limit of normal] or glomerular filtration rate of ? 50mL/min).Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) < 60 within 6 weeks prior to registrationXx_NEWLINE_xXCreatinine within institutional normal limits or glomerular filtration rate >= 50 mL/min/1.73 m^2 by Chronic Kidney Disease Epidemiology Collaboration (CKD EPI) equationXx_NEWLINE_xXSerum creatinine ? 1.5 x upper limit of normal (ULN) or, if serum creatinine > 1.5 x ULN, estimated glomerular filtration rate (eGFR) ? 30 mL/minXx_NEWLINE_xXGlomerular Filtration Rate ? 60 mL/min (according to Modification of the Diet in Renal Disease (MDRD) formula or cockroft & Gault formula)Xx_NEWLINE_xXCalculated glomerular filtration rate (GFR) > 50 ml/minXx_NEWLINE_xXCalculated creatinine clearance (CRCL) ?40 mL/min. Glomerular Filtration Rate (GFR) is calculated based on Cockcroft-Gault method.Xx_NEWLINE_xXWithin 14 days prior to first study treatment: Serum creatinine =< 1.5 x ULN OR creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimationXx_NEWLINE_xXGlomerular filtration rate > 60 ml/min/1.73 m^2Xx_NEWLINE_xXCalculated creatinine clearance > 50 ml/min/1.73m^2 as calculated by the Schwartz formula for estimated glomerular filtration rateXx_NEWLINE_xXSerum creatinine ? 1.25 x ULN; or if serum creatinine > 1.25 ULN, then calculated (Cockcroft-Gault formula, glomerular filtration rate (GFR) ? 60 mL/min;Xx_NEWLINE_xXGlomerular filtration rate (GFR) of 50 ml/minute or greater (if elevated serum creatinine level > 1.5 x ULN)Xx_NEWLINE_xXGlomerular filtration rate (GFR) of 50 mL/min or greaterXx_NEWLINE_xXCreatinine clearance or glomerular filtration rate greater than or equal to 50 mL/min/1.73 m^2Xx_NEWLINE_xXPediatric Population (age <18): Calculated creatinine clearance ? 90 ml/min/1.73m2 as calculated by the Schwartz formula for estimated glomerular filtration rate (GFR)Xx_NEWLINE_xXAdult Population (age >18): Serum creatinine <1.0 mg/dL; if serum creatinine >1.0 mg/dL, then the estimated glomerular filtration rate (GFR) must be >60 mL/min/1.73 m2Xx_NEWLINE_xXGlomerular filtration rate (GFR) < 60 mL/min/1.73 m^2 or calculated GFR < 60 mL/min/m^2 per Schwartz formulaXx_NEWLINE_xXCreatinine of =< 2 mg/dl and a calculated glomerular filtration rate (GFR) of > 50 mL/min/1.73 m^2Xx_NEWLINE_xXSubject has an estimated glomerular filtration rate (eGFr) of < 60ml/min as calculated by the modification of diet Renal disease (MDRD) Equation.Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) >/=50 mL/min per 1.73 m2 according to the Modification of Diet in Renal Disease Study Group (MDRD) formulaXx_NEWLINE_xXCreatinine clearance (CrCl) or glomerular filtration rate (GFR) >= 50 ml/min/1.73m^2Xx_NEWLINE_xXCalculated glomerular filtration rate (GFR) >= 60 ml/minXx_NEWLINE_xXCreatinine clearance (CrCL) or glomerular filtration rate (GFR) >= 50 ml/min/1.73 m^2Xx_NEWLINE_xXEstimated (calculated) or measured glomerular filtration rate >= 45 mL/min (or 45 mL/min/1.73 m^2); creatinine (mg/dl) used in calculation (Cockroft-Gault) must be obtained within 28 days prior to registrationXx_NEWLINE_xXCROSSOVER (STEP 2) REGISTRATION: Estimated (calculated) or measured glomerular filtration rate >= 45 mL/min (or 45 mL/min/1.73 m^2) within 28 days prior to registration; creatinine (mg/dl) used in calculation (Cockroft-Gault) must be obtained within 28 days prior to registrationXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 orXx_NEWLINE_xXRenal: estimated glomerular filtration rate (eGFR) using the modification of diet in renal disease (MDRD) formula ? 50 mL/min;Xx_NEWLINE_xXSerum creatinine < 1.5 x institutional ULN or an estimated glomerular filtration rate (eGFR) of > 50 ml/min as calculated by the Modification of Diet in Renal Disease (MDRD) equation.Xx_NEWLINE_xXGlomerular filtration rate >= 50 mL/min (calculated according to the formula of Cockcroft and Gault)Xx_NEWLINE_xXDoes the subject have an estimated glomerular filtration rate of at least 50 mL/min (inclusive) by the Cockcroft-Gault formula?Xx_NEWLINE_xXSerum creatinine < 1.5 X institutional ULN mg/dL OR glomerular filtration rate (GFR) >= 50 mL/minXx_NEWLINE_xXHeart: presence of mean left ventricular wall thickness on echocardiogram greater than 12 mm in the absence of hypertension or valvular heart disease, or unexplained low voltage (< 0.5 mV) on ECG, or NT-proBNP > 332 ng/L in the absence of impaired renal function [estimated glomerular filtration rate (eGFR) < 45 mL/min]Xx_NEWLINE_xXcreatinine ? 1.5 x upper limit of normal (ULN), or calculated glomerular filtration rate (GFR) > 50 mL/min if creatinine > 1.5x ULNXx_NEWLINE_xXCalculated glomerular filtration rate (GFR) must be >= 60 ml/min; GFR will be calculated as needed per institutional guidelinesXx_NEWLINE_xXEstimated creatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR) ? 30 mL/min/1.73 m2Xx_NEWLINE_xXGlomerular filtration rate (GFR) > 45 mL/min/1.73m^2 according to the Cockcroft-Gault estimation.Xx_NEWLINE_xXGlomerular filtration rate (GFR) >= 50 ml/minute using Cockroft-Gault formulaXx_NEWLINE_xXSubjects with severe renal impairment (GFR <50 mL/min/1.73 m²) or on dialysis.Xx_NEWLINE_xXMust have adequate organ function as defined by the following values: renal function - 24 hr creatinine clearance (revised Schwartz formula), or radioisotope glomerular filtration rate (GFR) >=60 milliliter (mL) per minute per 1.73 meter square (mL/min/1.73m^2); or a serum creatinine <=upper limit of normal (ULN) for age and gender; liver functions as bilirubin (sum of conjugated + unconjugated) <=1.5 x ULN for age, alanine aminotransferase (ALT) <=2.5 x ULN; for the purposes of enrollment and toxicity monitoring the ULN for ALT will be 45 unit per liter (U/L); cardiac function - corrected QT (QTcB) interval <480 milliseconds (msec), left ventricular ejection fraction (LVEF) >=lower limit of normal (LLN) by ECHO.Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2Xx_NEWLINE_xXAdequate renal and metabolic function defined as: calculated glomerular filtration rate (eGFR) (Schwartz formula), or radioisotope GFR >=90 milliliters/minutes (mL/min)/1.73 meter square (m^2); or a serum creatinine within the institutional reference range upper limit of normal (for age/gender, if available).Xx_NEWLINE_xXMeasured or calculated creatinine clearance >=50 milliliters per minute (mL/min) on the basis of the Cockcroft-Gault glomerular filtration rate estimation Cancer-Specific Inclusion Criteria:Xx_NEWLINE_xXCreatinine clearance or glomerular filtration rate of >= 70 ml/min/1.73m^2Xx_NEWLINE_xXCalculated creatinine clearance (estimated glomerular filtration rate [eGFR]) > 50 ml/minXx_NEWLINE_xXEstimated Glomerular Filtration Rate <45 mL/min.Xx_NEWLINE_xXestimated glomerular filtration rate > 50 mL/minXx_NEWLINE_xXCalculated creatinine, glomerular filtration rate (GFR) >= 30 cc/minuteXx_NEWLINE_xXNormal creatinine for age or glomerular filtration rate (GFR) >= 70/ml/min/1.73m^2Xx_NEWLINE_xXGlomerular filtration rate (GFR) > 40 ml/min/1.73m^2 orXx_NEWLINE_xXSerum creatinine < 2.0 mg/dl (provided they also have a glomerular filtration rate of at least 55 ml/min)Xx_NEWLINE_xXEstimated glomerular filtration rate (GFR) > 30 ml/minXx_NEWLINE_xXCreatinine 2 x ULN or glomerular filtration rate (GFR) > 50Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) of > 50 ml/min as calculated by the Cockcroft-Gault MethodXx_NEWLINE_xXCalculated glomerular filtration rate (GFR) > 50 ml/minuteXx_NEWLINE_xXSerum creatinine > 1.6 mg/dL or glomerular filtration rate < 50Xx_NEWLINE_xXGlomerular filtration rate > 60ml/min; OR =< ULN creatinine per institution normalsXx_NEWLINE_xXGlomerular filtration rate (GFR) < 45 ml/minXx_NEWLINE_xXGlomerular filtration rate (GFR) greater than or equal to 30 ml/min/1.73 m^2 by modification of diet in renal disease (MDRD)Xx_NEWLINE_xXUnless felt due to underlying disease and approved by the overall principal investigator (PI): Creatinine < 2.0 mg/dl, and estimated glomerular filtration rate (eGFR) >= 60 mL/minXx_NEWLINE_xXCalculated Glomerular filtration rate ? 50 mL/min;Xx_NEWLINE_xXSerum creatinine =< 1.5 mg/dL or calculated glomerular filtration rate (GFR) >= 60 mL/minXx_NEWLINE_xXGlomerular filtration rate (GFR) >= 30 ml/minXx_NEWLINE_xXSubjects with severe renal failure or end stage renal disease (estimated GFR [glomerular filtration rate] of < 30 mL/min) as estimated by the Cockcroft-Gault formulaXx_NEWLINE_xXGlomerular filtration rate (GFR) of >= 50 mL/min/1.73 m^2Xx_NEWLINE_xXGlomerular filtration rate (GFR) < 55 mL/minXx_NEWLINE_xXRenal insufficiency defined as estimated glomerular filtration rate of < 60 or hepatic insufficiency defined as transaminitis or hyperbilirubinemia of > 1.5 times the highest normal valueXx_NEWLINE_xXEstimated glomerular filtration rate (GFR) of < 50 mL/min/1.73 m^2Xx_NEWLINE_xXModification of diet in renal disease (MDRD) calculated glomerular filtration rate (GFR) < 30 mL/minXx_NEWLINE_xXCreatinine clearance or glomerular filtration rate (GFR) which is greater than or equal to 70 ml/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine within normal range, or if serum creatinine is outside normal range, then renal function (measured or estimated creatinine clearance or glomerular filtration rate [GFR]) >= 40 mL/min/1.73 m^2Xx_NEWLINE_xXChronic kidney disease with glomerular filtration rate < 30 ml/minXx_NEWLINE_xXEstimated glomerular filtration rate (GFR) >15 mL/min/1.73m2Xx_NEWLINE_xXGlomerular Filtration Rate (GFR) ? 30% (? 30 ml/min/1.73 m2)Xx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN) (or glomerular filtration rate >= 40 mL/min), obtained within 14 days of the first dose of study drugXx_NEWLINE_xXRenal function defined as a calculated or measured glomerular filtration rate (GFR) >= 30 mL/min; for Arm F carboplatin and pemetrexed, GFR >= 45 mL/minXx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) < 60 within 6 weeks prior to registrationXx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) >= 60 mL/min/1.73m^2, as evidenced in laboratory values =< 3 months oldXx_NEWLINE_xXSerum creatinine ? 2 times upper limits of normal or estimated glomerular filtration rate ? 60 mL/min/1.73 meter squared per Modification of Diet in Renal Disease equation (MDRD)Xx_NEWLINE_xXGlomerular filtration rate (GFR) < 30Xx_NEWLINE_xXDecreased glomerular filtration rate (GFR) (< 60 ml/min/1.73 m^2 as estimated by the revised Schwartz equation)Xx_NEWLINE_xXSerum creatinine > 1.6 mg/dL (141 umol/L) in females and > 1.9 mg/dL (168 umol/L) in males; patients with serum creatinine values exceeding these limits are eligible for the study if their estimated glomerular filtration rates (GFR) are > 30 ml/min/1.73 m^2Xx_NEWLINE_xXCreatinine < 2.0 mg/dL, for patient with a creatinine > 1.2 mg/dL or a history of renal dysfunction an estimated glomerular filtration rate > 40 mL/min/1.73 m^2 is requiredXx_NEWLINE_xXParticipants must have normal organ and marrow function as defined by a glomerular filtration rate (GFR) >= 60 mL/min/1.73 m^2 to be performed per clinical protocol.Xx_NEWLINE_xXParticipants with renal insufficiency or failure, as determined by glomerular filtration rate (GFR) < 60 mL/min/1.73 m^2, performed for all patients within 24 hours of the imaging examsXx_NEWLINE_xXGlomerular filtration rate (GFR) > 40Xx_NEWLINE_xXContraindication to contrast CMR including estimated glomerular filtration rate (eGFR) < 30 mls/min/1.73 m^2Xx_NEWLINE_xXEstimated creatinine clearance (for patients > 12 years) greater than 50.0 mL/minute (using the Cockcroft-Gault formula and actual body weight); for pediatric patients (> 1 year to 12 years), Glomerular Filtration Rate (GFR) estimated by the updated Schwartz formula ? 90.0 mL/min/1.73 m^2. If the estimated creatinine clearance is < 90 mL/min/1.73 m^2, then renal function must be measured by 24-hour creatinine clearance or nuclear GFR, and must be > 70.0 mL/min/1.73 m^2.Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) >= 45 mL/minXx_NEWLINE_xXHave significant renal disease or dysfunction defined as estimated glomerular filtration rate (eGFR) < 45Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 100 ml/min/1.73 m^2Xx_NEWLINE_xXRequirement for CD34+ stem cell selection for a second infusion of stem cells following an allogeneic stem cell transplant from a related or unrelated adult donor for the following conditions:\r\n* Primary graft rejection\r\n* Secondary graft rejection\r\n* Poor graft function \r\n* Disease recurrence\r\nNote: pre-infusion conditioning with chemotherapy and/or immunotherapy to be determined by the primary BMT physician and the protocol principal investigator (PI) based on clinical condition of the patient\r\n* Specific Organ System Function Requirements from PBMT 1001\r\n** Myeloablative\r\n*** Cardiac (shortening fraction of > 26% by echo or ejection fraction of > 47%)\r\n*** Renal (creatinine clearance or glomerular filtration rate [GFR] >= 40 ml/min, or > 60 ml/min.1.73 m^2)\r\n*** Pulmonary (DLCO > 50% by pulmonary function test [PFT])\r\n*** Liver (AST/ALT no greater than 3 times the upper limit of normal)\r\n** Reduced Intensity\r\n*** Cardiac (shortening fraction of > 20% by echo or ejection fraction of > 40%)\r\n*** Renal (creatinine clearance or GFR >= 30 ml/min, or > 40 ml/min 1.73 m^2)\r\n*** Pulmonary (DLCO > 40% by PFT)\r\n*** Liver (AST/ALT no greater than 5 times the upper limit of normal)Xx_NEWLINE_xXCreatinine =< 2.0 mg/dL, for patient with a creatinine > 1.2 mg/dL or a history of renal dysfunction an estimated glomerular filtration rate >= 40 mL/min/1.73 m^2 is requiredXx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limit of normal (ULN) (OR glomerular filtration rate [GFR] > 30 ml/min/1.73 m^2)Xx_NEWLINE_xXOR glomerular filtration rate (GFR) > 30 ml/min/1.73 m^2 obtained =< 45 days prior to randomizationXx_NEWLINE_xXGlomerular filtration rate (GFR) >= 60 ml/minXx_NEWLINE_xXEstimated glomerular filtration rate (GFR) < 35 ml/min/1.73 m^2Xx_NEWLINE_xXPatients must have adequate renal function: glomerular filtration rate (GFR) > 30 mL/min/1.73 m^2; for the test-retest sub-study MRI, patients must have a GFR of > 60 mL/min/1.73m^2Xx_NEWLINE_xXWomen who have a contraindication to the intravenous use of iodinated contrast agent (i.e., allergy to iodinated contrast or severely impaired renal function with a creatinine level > 1.3 or estimated glomerular filtration rate [eGFR] >= 45)Xx_NEWLINE_xXGlomerular filtration rate < 60 ml/min/1.73 m^2Xx_NEWLINE_xXPatient must have adequate bone marrow, coagulation, renal, and hepatic function; estimated glomerular filtration rate (eGFR) calculation >= 60 mL/min/1.73 m^2 (within 28 days of screening CT submission)Xx_NEWLINE_xXSevere renal insufficiency, estimated glomerular filtration rate (EGFR) < 30Xx_NEWLINE_xXAdequate renal function to tolerate intravenous gadolinium contrast injection (estimated glomerular filtration rate >= 45 mL/min/1.73 m^2 prior to initial DCE-MRI and estimated glomerular filtration rate >= 30 mL/min/1.73 m^2 for subsequent DCE-MRI scans)Xx_NEWLINE_xXContraindications to receiving intravenous gadolinium contrast injection including prior allergic reaction and/or chronic renal insufficiency (estimated glomerular filtration rate < 45 mL/min/1.73 m^2 prior to initial DCE-MRI and estimated glomerular filtration rate < 30 mL/min/1.73 m^2 for subsequent DCE-MRI scans)Xx_NEWLINE_xXPatient has a glomerular filtration rate (GFR) > 60. In patients with moderate renal failure (GFR 30-60), an alternate injection with 2 times half-dose multihance (gadobenate dimeglumine) or gadovist (gadobutrol) will be considered, if a contrast exam is deemed clinically necessary.Xx_NEWLINE_xXPatients with a glomerular filtration rate (GFR) < 30 ml/min are ineligible to receive intravenous contrast per standard magnetic resonance (MR) exclusion criteriaXx_NEWLINE_xXSevere kidney dysfunction (glomerular filtration rate [GFR] < 30 mL/min/1.73m^2)Xx_NEWLINE_xXSubjects with a calculated glomerular filtration rate (GFR) >= 60 mL/min/1.73 m^2Xx_NEWLINE_xXSubjects with a calculated glomerular filtration rate (GFR) > 60 mL/min/1.73 m^2Xx_NEWLINE_xXSubject has impaired renal function (estimated glomerular filtration rate [eGFR]< 30 mL/min)Xx_NEWLINE_xXFor patients with known history of allergic reaction to MR contrast material or abnormal kidney function (glomerular filtration rate [GFR] < 30 mL/min), a contrast enhanced exam will not be performed; however, a non-contrast exam may be performed in these patientsXx_NEWLINE_xXRenal dysfunction with estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m^2Xx_NEWLINE_xXAbnormal renal function with estimated glomerular filtration rate (eGFR) less than 30 mL/min/m^2 based on creatinine obtained within last 30 daysXx_NEWLINE_xXElevated creatinine and/or glomerular filtration rate (GFR) < 40 ml/min/1.7 sqm (exclusion criterion only for contrast enhanced MRI)Xx_NEWLINE_xXPatients with an estimated glomerular filtration rate (eGFR) =< 30 will be excluded to avoid issues related to contrast administration in such patients; this glomerular filtration rate (GFR) threshold cutoff level is chosen per institutional policy, because below that level other measures would be required (hydration or no contrast administration); in order to keep the imaging information as uniform as possible in such a small study group, patients with a low GFR will not be enrolled in the studyXx_NEWLINE_xXHave a calculated glomerular filtration rate (GFR) =< 30 mL/min/1.73 m^2Xx_NEWLINE_xXAre receiving any form of renal replacement therapy or have a calculated glomerular filtration rate (GFR) < 30 mL/min/1.75 m²; results of serum creatinine testing will be reviewed for calculation of glomerular filtration rate (GFR); patients without a serum creatinine level drawn within the prior 3 months will have this drawn upon enrollmentXx_NEWLINE_xXPatients with moderate to end-stage renal (kidney) disease, defined as a glomerular filtration rate (GFR) less than 30 mL/day/1.73m^2Xx_NEWLINE_xXPatients with renal failure, defined as glomerular filtration rate (GFR) < 60 at the time of the radiation treatment-planning (RTP) scan, will be excludedXx_NEWLINE_xXHave kidney disease, defined as either CKD II-V, determined by estimated glomerular filtration rate (GFR) of < 90 and derived from serum creatinine measurements, or albuminuria/proteinuria, determined by albumin to creatinine ratio or protein to creatinine ratio of > 30 mg/gm within 3 months of recruitment, or on dialysis or having received a kidney transplant or have biopsy proven kidney diseaseXx_NEWLINE_xXSevere renal function impairment (estimated glomerular filtration rate [eGFR] < 45 mL/min/1.73 m^2) would make the patient inappropriate for enrollment due to the increased risk of nephrogenic systemic fibrosis (NSF) with higher dose of IV gadolinium-based contrast agents (GBCA) administrationXx_NEWLINE_xXSubjects with estimated glomerular filtration rate (eGFR) =< 30 mL/min/1.73 m^2 will not participate in the gadolinium (Gd) contrast-enhanced MRIXx_NEWLINE_xXPatients with estimated glomerular filtration rate (eGFR) < 30 are not eligibleXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 30 mL/min/1.73 m^2Xx_NEWLINE_xXPatients with severe chronic renal insufficiency (glomerular filtration rate < 30 mL/min/1.73 m^2), hepatorenal syndrome or post-liver transplantationXx_NEWLINE_xXPatients with renal function (estimated glomerular filtration rate [eGFR] >= 30)Xx_NEWLINE_xXGlomerular filtration rate (GFR) >= 40Xx_NEWLINE_xXLate stage renal failure with estimated glomerular filtration rate (eGFR) of less than 30 mL/min/1.73 m^2 based on patient's serum creatinine; (‘past’ 3 months timeframe will be used to calculate the eGFR)Xx_NEWLINE_xXRenal insufficiency: glomerular filtration rate (GFR) < 40ml/min/1.73) and following European Society of Urogenital Radiology (ESUR) guidelines (exclusion criterion only for contrast enhanced MRI)Xx_NEWLINE_xXParticipants with diagnosis of renal insufficiency or glomerular filtration rate (GFR) < 60 ml/min/1.73m^2Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) < 30 mL/min/1.73m^2Xx_NEWLINE_xXContraindications for MRI with contrast or PET/CT including:\r\n* Cardiac pacemaker, implanted cardiac defibrillator, pacing wires, internal electrodes\r\n* Aneurysm clips\r\n* Cochlear, otologic, or other ear implant\r\n* Tissue expander\r\n* Swan-Ganz or thermodilution\r\n* Moderate renal insufficiency (estimated glomerular filtration rate [GFR] less than 60 mL/min/1.73 m^2) to end stage renal disease (estimated GFR less than 15 mL/min/1.73 m^2 or a serum creatinine more than 3 mg/dL), who are not on dialysis, and patients with renal failure on chronic dialysis\r\n* Severe claustrophobiaXx_NEWLINE_xXPatients with renal insufficiency with a glomerular filtration rate (GFR) < 30Xx_NEWLINE_xXCreatinine serum level >= 2 mg/dL or glomerular filtration rate (GFR) =< 30 mL/min/1.73 m^2 (contraindication for intravenous [i.v.] gadolinium only)Xx_NEWLINE_xXPatients must have an estimated glomerular filtration rate of >= 30 mL/min/1.73m^2 within six weeks of the MRI to be included in the studyXx_NEWLINE_xXSubjects with an estimated glomerular filtration rate of < 30 mL/min/1.73m^2 within six weeks of the MRIXx_NEWLINE_xXAcute or chronic severe renal insufficiency (estimated glomerular filtration rate < 30 mL/min/1.73m^2)Xx_NEWLINE_xXSubjects must have a serum creatinine < 2.0 mg/dL and/or calculated glomerular filtration rate (GFR) 50 ml/min/1.73 m^2 (Modification of Diet in Renal Disease [MDRD] formula) or greaterXx_NEWLINE_xXPatient with significant renal insufficiency, i.e. an estimated glomerular filtration rate (eGRF) less than 30 mL/min/1.73m^2Xx_NEWLINE_xXSubjects with glomerular filtration rate (GFR) < 50Xx_NEWLINE_xXCreatinine > 1.8 mg/dL OR glomerular filtration rate (GFR) < 30 mL/minXx_NEWLINE_xXGlomerular filtration rate (GFR) > 30 ml/minXx_NEWLINE_xXPatients with renal insufficiency; glomerular filtration rate (GFR) < 60Xx_NEWLINE_xXPatients with renal insufficiency; glomerular filtration rate (GFR) < 60Xx_NEWLINE_xXNormal creatinine and estimated glomerular filtration rate (GFR) within 30 days under the following circumstances:\r\n* Had abnormal creatinine in the last 60 days\r\n* Are over 60 years of age\r\n* Has received chemotherapy within the past 30 days\r\n* Has diabetes, human immunodeficiency virus (HIV), renal disease or history (hx) of renal cancerXx_NEWLINE_xXRenal dysfunction as defined as a glomerular filtration rate (GFR) < 70Xx_NEWLINE_xXBaseline glomerular filtration rate (GFR) < 50 mL/min/1.73m^2Xx_NEWLINE_xXIf agreeing to MRI contrast, participant must not have renal insufficiency (glomerular filtration rate [GFR] < 30 mL/min/1.73 m^2) measured within the past 60 daysXx_NEWLINE_xXGlomerular filtration rate (GFR) < 50Xx_NEWLINE_xXPatient must not have an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m^2Xx_NEWLINE_xXIn addition, patients with glomerular filtration rate (GFR) < 15 ml/min/1.73m^2 or who are on dialysis will be excluded from the studyXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 ORXx_NEWLINE_xXSerum creatinine =< 1.5 x the upper limit of normal (ULN) or an estimated glomerular filtration rate (eGFR) calculated using the modification of diet in renal disease (MDRD) equation of at least 45 mL/min/1.73 m^2Xx_NEWLINE_xXSerum creatinine ? 1.5 x institutional upper limit of normal (ULN), or if serum creatinine outside normal range, then glomerular filtration rate (GFR) > 40 mL/min/1.73m^2 as calculated with the 4-parameter Modification of Diet in Renal Disease (MDRD) equation.Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m^2Xx_NEWLINE_xXPatients with glomerular filtration rate (GFR) < 15 ml/min/1.73 m^2 or who are on dialysis will be excluded from the studyXx_NEWLINE_xXRenal failure, as determined by estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m^2 by the Modification of Diet in Renal Disease (MDRD) model based on a serum creatinine level obtained within 28 days prior to enrollmentXx_NEWLINE_xXSubjects with renal insufficiency; glomerular filtration rate (GFR) < 50Xx_NEWLINE_xXImpaired renal function (chronic kidney disease [CKD] 4 or 5: estimated glomerular filtration rate [eGFR] < 30 mLs/min), which is a contraindication to gadolinium containing contrastXx_NEWLINE_xXEstimated glomerular filtration rate (GFR) >= 30 mL/min/1.73 m^2Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) < 30 mL/minXx_NEWLINE_xXPatients with inadequate renal function (creatinine >= 1.5 times upper limit of normal) or acute or chronic renal insufficiency (glomerular filtration rate < 20 ml/min)Xx_NEWLINE_xXEstimated glomerular filtration rate < 30 mL/minXx_NEWLINE_xXSubject presenting with acute or chronic Grade III (at least) renal insufficiency, defined as an estimated Glomerular Filtration Rate (eGFR) <60 mL/min/1.73m² based on two eGFR assessments, one within 7 days before the first study MRI and on the day of the MRI (if any of the eGFR result is <60 mL/min/1.73m², the subject is not eligible).Xx_NEWLINE_xXContraindication to MRI (e.g. claustrophobia, pacemaker, estimated glomerular filtration rate ? 50mls/min)Xx_NEWLINE_xXSerum creatinine within 3 weeks prior to Eovist MRI =< 1.8 mg/dl and estimated glomerular filtration rate (eGFR) must be > 30 ml/min/1.73 m^2Xx_NEWLINE_xXGFR (glomerular filtration rate) < 30 on labs drawn within 6 weeks of imagingXx_NEWLINE_xXRenal insufficiency (defined as glomerular filtration rate [GFR] < 30 mL/min/1.73 m^2) measured no more than 60 days before the first research scan) which precludes safe administration of the contrast agentXx_NEWLINE_xXPatients with glomerular filtration rates < 30 mL/min/1.73m^2Xx_NEWLINE_xXEstimated glomerular filtration rate (GFR) (using Cockcroft formula) less than 30 ml/min/1.73 m^2Xx_NEWLINE_xXCompromised renal function with estimated glomerular filtration rate (GFR) of < 30 ml/min/1.73m^2Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) >= GFR 70 mL/min/1.73 m^2Xx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m^2 or estimated creatinine clearance (eCrCL) > 60 mL/minXx_NEWLINE_xXSerum creatinine > 1.5 mg/dL or glomerular filtration rate < 50Xx_NEWLINE_xXHave an estimated glomerular filtration rate (eGFR) (using the Cockcroft-Gault equation) of more than 60 mL/minXx_NEWLINE_xXEstimated glomerular filtration rate (eGFR) ? 40 mL/min per 1.73 m^2 according to the Modification of Diet in Renal Disease Study Group (MDRD) formulaXx_NEWLINE_xX