Cluster 0: bisphosphonate hypercalcemia denosumab therapy symptomatic osteoporosis use allowed uncontrolled reasons Cluster 1: breast cancer metastatic inflammatory diagnosis prior patients diagnosed therapy stage Cluster 2: voluntary written consent informed related performance procedure signed donor research Cluster 3: mcl anc neutrophil absolute count 500 days initiation performed treatment Cluster 4: contraception use agree effective study male potential dose childbearing female Cluster 5: performance oncology group eastern cooperative ecog status score scale ps Cluster 6: platelet 000 count 100 mm ul 50 transfusion days mm3 Cluster 7: creatinine gault equation cockcroft clearance min ml calculated estimated using Cluster 8: bilirubin upper normal limit total uln institutional gilbert serum syndrome Cluster 9: pd anti l1 l2 prior therapy agent received inhibitor treatment Cluster 10: test pregnancy negative urine serum female childbearing potential 72 hours Cluster 11: heart york association new class failure nyha congestive iv iii Cluster 12: 25 marrow bone radiation therapy prior radiotherapy weeks received irradiated Cluster 13: hiv positive known infection immunodeficiency patients virus human cd4 antiretroviral Cluster 14: bilateral potential consecutive hysterectomy oophorectomy undergone months ligation tubal childbearing Cluster 15: fasting glucose mg dl 300 mmol triglycerides cholesterol plasma serum Cluster 16: cancer skin non melanoma malignancy situ years carcinoma cervix history Cluster 17: hemoglobin dl transfusion days mmol registration erythropoietin 14 prior dependency Cluster 18: aspartate ast aminotransferase uln days obtained transaminase registration metastases liver Cluster 19: sign consent informed able understand written willing document form legal Cluster 20: nervous central cns metastases brain disease patients treated stable metastasis Cluster 21: lactation pregnancy breastfeeding test positive current year women time period Cluster 22: expectancy life 12 weeks greater estimated patients 16 investigator equal Cluster 23: adhere requirements able schedule rems program visit protocol willing revlimid Cluster 24: medical illness psychiatric interfere condition conditions uncontrolled study investigator compliance Cluster 25: half lives shorter whichever investigational prior weeks therapy drug days Cluster 26: albumin dl serum mg days initiation treatment performed 14 gm Cluster 27: requiring infection systemic active therapy antibiotic treatment 14 days intravenous Cluster 28: inability unwillingness comply consent informed tolerate protocol follow procedures lie Cluster 29: 18 age years older old time males consent females patients Cluster 30: treatment prior study previous patients received months disease inhibitors patient Cluster 31: transaminase glutamic serum aminotransferase sgot oxaloacetic aspartate ast uln pyruvic Cluster 32: bearing child potential pregnancy test women negative pregnant serum female Cluster 33: liver disease cirrhosis chronic hepatitis function viral active history biliary Cluster 34: measurable disease evaluable patients lesion non defined cm criteria lesions Cluster 35: birth control potential use study effective method agree childbearing women Cluster 36: study pregnant inform suspect immediately agree contraception duration barrier woman Cluster 37: stem transplant cell allogeneic autologous hematopoietic prior host months graft Cluster 38: bowel gastrointestinal gi significantly vomiting absorption malabsorption nausea function disease Cluster 39: hiv immunodeficiency virus human known infection positive history antibodies patients Cluster 40: cancer bladder superficial carcinoma situ skin years malignancy cell basal Cluster 41: colony stimulating csf granulocyte factor factors gm macrophage weeks erythropoietin Cluster 42: surgery major weeks prior study recovered drug dose effects starting Cluster 43: hcg chorionic gonadotropin beta human test pregnancy negative potential women Cluster 44: pt anticoagulant intended anticoagulants ptt time range therapeutic thromboplastin partial Cluster 45: bp mmhg pressure blood hypertension diastolic systolic antihypertensive 90 140 Cluster 46: infection uncontrolled active patients severe ongoing systemic eligible evidence presence Cluster 47: response criteria recist solid evaluation tumors measurable disease version evaluable Cluster 48: brain metastases known patients stable treated metastasis symptomatic excluded untreated Cluster 49: illness social situations compliance intercurrent uncontrolled requirements psychiatric limited pectoris Cluster 50: ul absolute neutrophil count 500 anc 000 cells 750 lymphocyte Cluster 51: mg dl creatinine serum years age bilirubin maximum male 13 Cluster 52: composition compounds similar chemical allergic attributed reactions biologic history used Cluster 53: mm longest measured measurable accurately dimension lesion diameter ct recorded Cluster 54: therapy chemotherapy immunotherapy cancer biologic hormonal radiation prior concurrent investigational Cluster 55: therapy prior received patients systemic disease line anti allowed treatment Cluster 56: steroid therapy immunosuppressive form systemic receiving immunodeficiency diagnosis days dose Cluster 57: transplant organ allogeneic history solid prior allograft marrow autologous bone Cluster 58: unwilling unable protocol comply follow requirements study patients consent abide Cluster 59: donor hla matched unrelated related donors leukocyte antigen drb1 typing Cluster 60: live vaccine 30 days attenuated received prior dose study vaccination Cluster 61: tumor biopsy primary cm patients solid biopsies brain evidence accessible Cluster 62: inhibitor prior treatment kinase therapy received mek parp tyrosine mtor Cluster 63: aminotransferase alanine alt uln ast aspartate liver metastases times involvement Cluster 64: mg equivalent prednisone day corticosteroids 10 dose daily steroids systemic Cluster 65: pregnancy breastfeeding nursing donor current test lactating planning known active Cluster 66: hemoglobin 10 dl gm transfusion achieve days intervention hgb acceptable Cluster 67: carcinoma cell squamous basal skin situ malignancy cervix years treated Cluster 68: inclusion criteria registration meet apply cohort patients phase specific pre Cluster 69: qt qtc interval corrected msec ms 470 qtcf 450 480 Cluster 70: karnofsky performance 70 status 60 kps score 80 scale lansky Cluster 71: mpn advanced blasts mds marrow bone 10 biphenotypic tkis assigned Cluster 72: receiving currently patients eligible treatment agents anti therapy study investigational Cluster 73: pregnant nursing patients female females patient subjects excluded currently study Cluster 74: cardiac ventricular fibrillation arrhythmias atrial history arrhythmia block uncontrolled heart Cluster 75: specific consent informed study procedures prior provide entry signed patient Cluster 76: strong cyp3a4 inducers inhibitors cytochrome p450 subfamily family cyp3a polypeptide Cluster 77: advanced locally metastatic unresectable disease histologically cancer confirmed solid recurrent Cluster 78: informed consent written signed obtained procedures provided study prior given Cluster 79: hospitalization requiring registration exacerbation precluding respiratory obstructive transmural coagulation months Cluster 80: creatinine institutional normal 73 clearance levels min ml 60 limits Cluster 81: trial clinical participation investigational study therapeutic trials days treatment concurrent Cluster 82: inr normalized international ratio prothrombin pt uln time coagulation warfarin Cluster 83: cns metastases nervous central patients involvement symptomatic disease stable treated Cluster 84: platelets mcl 000 initiation 100 days performed treatment 10 14 Cluster 85: neuropathy grade peripheral pain greater higher existing baseline patients examination Cluster 86: hepatitis reactive qualitative hbsag rna detected hcv ribonucleic surface acid Cluster 87: interstitial lung disease history pulmonary evidence signs symptoms known fibrosis Cluster 88: english read speak able speaking understand spanish write ability language Cluster 89: significant clinically cardiac disease uncontrolled history pulmonary active investigator dysfunction Cluster 90: growth factor receptor epidermal factors egfr endothelial vegf support prior Cluster 91: expectancy life months estimated investigator 12 years patients opinion anticipated Cluster 92: nervous central involvement known metastases lymphoma active metastasis malignancy leukemia Cluster 93: pregnancy childbearing test negative potential women serum days prior urine Cluster 94: docetaxel prior treatment chemotherapy cabazitaxel prostate received cancer patients paclitaxel Cluster 95: fraction ejection left ventricular lvef 50 40 cardiac 45 echocardiogram Cluster 96: procedure surgical major anticipation prior study course need days weeks Cluster 97: fraction muga echocardiogram ejection acquisition scan gated left ventricular lvef Cluster 98: weeks earlier entering administered adverse events recovered agents radiotherapy nitrosoureas Cluster 99: ovarian peritoneal fallopian tube epithelial cancer primary carcinoma serous recurrent Cluster 100: bacterial fungal viral infection active uncontrolled infections systemic requiring antibiotics Cluster 101: places confounds interpret unacceptable abnormalities condition laboratory data participate study Cluster 102: alkaline phosphatase uln limit normal upper liver alp bone times Cluster 103: leukemia acute aml promyelocytic myeloid chronic myelogenous plasma remission cell Cluster 104: heart failure congestive uncontrolled angina unstable myocardial infarction cardiac symptomatic Cluster 105: chemotherapy prior received cytotoxic patients regimen regimens treatment systemic cancer Cluster 106: transaminase aminotransferase serum pyruvate glutamate sgpt glutamic oxaloacetic sgot alt Cluster 107: hgb hemoglobin dl transfusion achieve 10 intervention acceptable days note Cluster 108: absolute neutrophil mm count 500 anc cells 000 750 mm3 Cluster 109: cancer prostate diagnosis lung cell small prior patients treatment therapy Cluster 110: autoimmune atopy asthma childhood subjects syndrome systemic vitiligo excluded resolved Cluster 111: warfarin heparin anticoagulation low weight molecular therapeutic vitamin dose aspirin Cluster 112: zubrod performance status patients registration days prior step ps 28 Cluster 113: capacity forced predicted dlco carbon monoxide fev1 expiratory volume pulmonary Cluster 114: cycle day prior weeks days treatment therapy investigational infection signs Cluster 115: pneumonitis infectious steroids required non current history interstitial evidence active Cluster 116: feeding breast pregnant women females pregnancy female patients lactating planning Cluster 117: abuse substance cooperation disorders interfere psychiatric requirements known trial alcohol Cluster 118: voluntarily understand sign informed consent form assessments procedures conducted related Cluster 119: autoimmune disease active history requiring suspected systemic vitiligo known hypothyroidism Cluster 120: hypersensitivity known excipients history reaction pembrolizumab severe components reactions drugs Cluster 121: coagulopathy diathesis bleeding evidence history anticoagulation significant therapeutic absence disorder Cluster 122: transplantation organ allogeneic solid prior marrow bone stem cell history Cluster 123: lactating pregnant women females female patients nursing study excluded subject Cluster 124: platinum based chemotherapy regimen disease therapy progression line prior received Cluster 125: standard therapy care advanced refractory solid available patients treatment metastatic Cluster 126: seizure disorder history patients seizures medication requiring controlled uncontrolled anticonvulsants Cluster 127: surgery major days prior 28 14 study recovered dose enrollment Cluster 128: glomerular filtration rate min ml gfr creatinine estimated 73 renal Cluster 129: trial subject confound best abnormality results interfere participate laboratory duration Cluster 130: tablets swallow able unable capsules intact patients inability ability subject Cluster 131: eastern cooperative oncology group ecog performance status ps patients patient Cluster 132: corticosteroids systemic immunosuppressive inhaled steroids topical prednisone doses treatment use Cluster 133: hypertension uncontrolled diabetes pulmonary controlled despite medical poorly severe history Cluster 134: lenalidomide thalidomide prior hypersensitivity pomalidomide therapy treatment bortezomib dexamethasone carfilzomib Cluster 135: participants study prior treatment therapy received receiving eligible disease research Cluster 136: weeks prior study therapy treatment chemotherapy dose enrollment received drug Cluster 137: cll lymphocytic sll leukemia chronic transformation lymphoma iwcll diagnosis richter Cluster 138: agents investigational receiving patients participants currently concurrent study use subjects Cluster 139: world organization health diagnosis aml confirmed classification grade criteria histologically Cluster 140: cns nervous central involvement active metastases known leukemia lymphoma disease Cluster 141: expecting conceive trial projected screening children father breastfeeding visit 120 Cluster 142: stage iv iii cancer disease ajcc ii melanoma breast nsclc Cluster 143: adenocarcinoma histologically prostate confirmed cytologically pancreatic pancreas diagnosis metastatic proven Cluster 144: anticancer therapy investigational treatment prior weeks concurrent therapies agents study Cluster 145: samples research purposes provide correlative willing blood tissue mandatory willingness Cluster 146: abdominal perforation gastrointestinal fistula abscess intra history months gi bowel Cluster 147: study interfere results investigator interpretation participation condition judgment inappropriate patient Cluster 148: paraffin tissue tumor slides embedded formalin fixed unstained block ffpe Cluster 149: grade toxicity prior therapy recovered alopecia toxicities related adverse baseline Cluster 150: demonstrated function adequate liver reserve following organ marrow inadequate bone Cluster 151: leukocytes 000 mcl ul mm microliter 500 days registration 14 Cluster 152: antiretroviral combination hiv immunodeficiency positive ineligible virus human therapy patients Cluster 153: ct tomography imaging computed scan mri pet resonance magnetic disease Cluster 154: her2 receptor er ihc negative positive estrogen breast progesterone fish Cluster 155: 75 000 platelets platelet count mm ul mcl 10 plt Cluster 156: exclusion criteria apply registration cohort treatment specific protocol patients inclusion Cluster 157: nature informed aware consent indicating investigational sign risks study benefits Cluster 158: surgically childbearing sterile potential abstain heterosexual activity sterilized study methods Cluster 159: pregnancy test positive lactating female serum screening period women pregnant Cluster 160: female male pregnant potential subjects childbearing patients breastfeeding participants subject Cluster 161: organomegaly endocrinopathy polyneuropathy poems changes monoclonal protein syndrome skin plasma Cluster 162: replacement systemic thyroxine pituitary insulin modifying physiologic adrenal insufficiency therapy Cluster 163: criteria eligibility meet medi following phase cohort study patients laboratory Cluster 164: myocardial infarction months angina unstable history prior coronary study acute Cluster 165: allergy known hypersensitivity components history study excipients formulations drug reaction Cluster 166: days prior 14 28 study registration dose drug 30 therapy Cluster 167: adjuvant chemotherapy therapy neoadjuvant prior setting months metastatic neo treatment Cluster 168: carcinoma skin cell potentially progressing curative basal exceptions undergone additional Cluster 169: terminology common adverse ctcae events grade criteria version alopecia toxicities Cluster 170: ul platelets 100 000 10 days plt cells 14 prior Cluster 171: provide informed consent written ability unable willingness procedures patients understand Cluster 172: consent informed authorization health written ability information study hipaa provide Cluster 173: bilirubin total uln mg dl gilbert syndrome direct serum subjects Cluster 174: pugh child class score hepatic impairment cirrhosis liver severe classification Cluster 175: organ function adequate defined hematologic end marrow laboratory following values Cluster 176: ng psa ml testosterone prostate dl 50 serum level rising Cluster 177: mcl neutrophil absolute 500 count anc 000 microliter 200 days Cluster 178: neutrophil absolute count 10 anc 109 cells days 000 14 Cluster 179: mri imaging contrast magnetic resonance undergo contraindication patients brain gadolinium Cluster 180: opinion investigator condition medical study patient compromise subject safety participation Cluster 181: oral swallow medication retain able medications ability patient patients unable Cluster 182: radiotherapy prior weeks chemotherapy treatment study palliative received days patients Cluster 183: meningitis carcinomatous metastases nervous central cns brain known evidence active Cluster 184: healing wound fracture ulcer non bone presence active untreated 28 Cluster 185: visits comply scheduled able willing tests procedures laboratory treatment study Cluster 186: ascites pleural effusion effusions pericardial paracentesis requiring drainage clinically significant Cluster 187: breastfeeding pregnant women females female patients patient subject excluded study Cluster 188: leptomeningeal disease brain metastases carcinomatosis metastasis cord spinal compression history Cluster 189: protein light serum chain dl free mg flc abnormal ratio Cluster 190: histologically confirmed cytologically diagnosis metastatic cancer cell carcinoma patients solid Cluster 191: creatinine gault cockcroft clearance formula min ml calculated using 50 Cluster 192: planned therapy surgery treatment study radiation chemotherapy weeks current use Cluster 193: tissue tumor biopsy archival available fresh sample analysis provide availability Cluster 194: lymph node nodes axillary sentinel cm biopsy dissection disease regional Cluster 195: able consent provide informed written willing trial assent study patients Cluster 196: infections active uncontrolled requiring systemic illnesses antibiotics opportunistic severe medical Cluster 197: diabetes mellitus type uncontrolled controlled a1c insulin poorly hba1c glucose Cluster 198: thrombosis deep embolism pulmonary vein venous history dvt months arterial Cluster 199: limits normal institutional bilirubin total upper creatinine uln serum gilbert Cluster 200: creatinine uln serum institutional times renal days registration cr obtained Cluster 201: upper normal limit ast alt times bilirubin uln institutional range Cluster 202: syndrome qt history long myelodysplastic congenital gilbert known family patients Cluster 203: site staff primary study disease conduct astrazeneca tumor applies biopsy Cluster 204: greater equal dl grade hemoglobin years cm age patients 10 Cluster 205: myeloma multiple diagnosis relapsed refractory imwg therapy criteria working international Cluster 206: satisfy criteria following enrolled subjects patient study patients portion enrollment Cluster 207: patients history disease study patient prior subjects use months known Cluster 208: function adequate renal hepatic hematologic liver defined hematological coagulation cardiac Cluster 209: board review irb approved institutional consent informed sign understand written Cluster 210: autoimmune past years systemic disease active treatment required requiring documented Cluster 211: methods abstinence ovulation practice contraception agree lifestyle usual periodic true Cluster 212: infectious pneumonitis non active evidence known history process disease clinical Cluster 213: women potential contraception childbearing use men effective contraceptive method sexually Cluster 214: obtained newly tissue biopsy excisional core tumor lesion specimen archival Cluster 215: hepatitis virus immunodeficiency hiv human infection active known hcv hbv Cluster 216: willingness understand sign ability written document informed consent subjects subject Cluster 217: bowel disease inflammatory colitis crohn ulcerative autoimmune history active arthritis Cluster 218: tb tuberculosis bacillus active known history excluded patients latent patient Cluster 219: hepatitis active infection known chronic hiv history viral positive patients Cluster 220: pneumonitis fibrosis idiopathic organizing pneumonia induced pulmonary history chest obliterans Cluster 221: ecog performance status score ps patients appendix gog scale equal Cluster 222: tuberculosis active history known previous clinical diagnosis latent infection hepatitis Cluster 223: creatinine upper normal limit uln serum institutional times age limits Cluster 224: 1500 neutrophil absolute count anc mm ul cells mm3 10 Cluster 225: weeks earlier monoclonal administered recovered antibody adverse events mab prior Cluster 226: lansky 16 karnofsky score years 50 age performance patients 60 Cluster 227: care medical consent prejudice withdrawn future understanding voluntary procedure written Cluster 228: women pregnant nursing excluded study employ unwilling men contraception following Cluster 229: lipase amylase uln serum pancreatitis normal radiologic upper clinical limit Cluster 230: invasive breast cancer carcinoma dcis ductal situ diagnosis lobular contralateral Cluster 231: trc102 mother discontinued breastfeeding excluded treated pregnant women study episode Cluster 232: swallow capsules pills able inability unable patients tablet ability patient Cluster 233: time thromboplastin partial ptt prothrombin pt inr uln normalized ratio Cluster 234: immunodeficiency acquired aids primary known syndrome hiv history virus human Cluster 235: ischemic attack transient cerebrovascular accident months stroke history myocardial coronary Cluster 236: hepatitis positive virus hcv antibody antigen hbv surface infection test Cluster 237: conjugated sum unconjugated bilirubin age upper uln limit normal direct Cluster 238: creatinine clearance calculated uln crcl place institutional gfr measured glomerular Cluster 239: platelets 000 50 mcl mm ul 10 cells 80 transfusion Cluster 240: aminotransferase upper aspartate alanine ast normal alt limit uln times Cluster 241: condom intercourse drug males father sexually vasectomized stopping taking child Cluster 242: grapefruit juice seville oranges cyp3a4 fruits inhibitors star fruit study Cluster 243: stroke hemorrhage intracranial history months enrollment prior accident cerebrovascular cerebral Cluster 244: protein urine 24 hour ratio proteinuria creatinine dipstick upc mg Cluster 245: finding metabolic reasonable suspicion contraindicates examination dysfunction physical render giving Cluster 246: marrow bone function adequate renal liver organ hepatic kidney defined Cluster 247: bone marrow blasts blood patients peripheral biopsy disease transplant aspirate Cluster 248: traumatic injury major procedure significant surgical open biopsy days 28 Cluster 249: vaccines live attenuated influenza flu seasonal allowed inactivated intranasal vaccine Cluster 250: expectancy life greater months weeks equal estimated 12 physician patients Cluster 251: guidelines informed federal consent accordance institutional written nature sign investigational Cluster 252: comply study procedures requirements able protocol follow willing inability investigator Cluster 253: count absolute neutrophil 000 mm3 anc lymphocyte 109 cells mm Cluster 254: mother breastfeeding discontinued pregnant excluded women treated study agents potential Cluster 255: cerebrovascular accident transient embolic ischemic attacks thrombotic venous events thrombosis Cluster 256: hemoglobin dl hb mmol gm mg greater 90 11 weeks Cluster 257: potassium calcium magnesium serum normal lln lower corrected limits mmol Cluster 258: signed informed consent form dated patient document guardian study given Cluster 259: malignancy years active history concurrent treatment prior diagnosed patients treated Cluster 260: fcbp agree pregnancy contact lenalidomide latex sexual potential childbearing vasectomy Cluster 261: return follow institution enrolling willing monitoring phase active mayo clinic Cluster 262: bleeding diathesis active history gastrointestinal significant disorders disorder hemorrhage known Cluster 263: sensory neuropathy grade motor peripheral ctcae alopecia equal related persisting Cluster 264: anti pd antibody ctla programmed death l1 cell checkpoint l2 Cluster 265: karnofsky performance eastern cooperative oncology ecog group status 60 70 Cluster 266: pressure hg blood mm systolic diastolic hypertension 90 uncontrolled 140 Cluster 267: mmhg pressure blood systolic diastolic hypertension 90 uncontrolled 150 140 Cluster 268: 1000 neutrophil absolute count anc mm ul support filgrastim days Cluster 269: male female 18 years age older aged patients subjects consent Cluster 270: uln alt ast liver transaminase alanine metastases aspartate aminotransferase bilirubin Cluster 271: effects recovered toxic prior acute therapy fully grade chemotherapy reversible Cluster 272: absorption gastrointestinal malabsorption gi interfere oral condition disease syndrome medication Cluster 273: antibiotics infection requiring active intravenous parenteral iv antifungals antivirals systemic Cluster 274: creatinine clearance min ml calculated 50 serum 60 30 mg Cluster 275: lymphoma cell hodgkin large follicular diffuse dlbcl refractory mantle non Cluster 276: interstitial pneumonitis lung disease history infectious evidence active non pulmonary Cluster 277: cancer treated adequately cell situ skin malignancy years basal squamous Cluster 278: postmenopausal menopausal hormone women post fsh year follicle bilateral oophorectomy Cluster 279: transplantation stem cell allogeneic autologous hematopoietic prior patients eligible graft Cluster 280: contraception methods intrauterine barrier device use method contraceptive potential condom Cluster 281: brentuximab vedotin prior treatment bv hypersensitivity received previous dose bendamustine Cluster 282: dose contraception 120 study method adequate male use starting therapy Cluster 283: disorder psychiatric history bipolar uncontrolled medical schizophrenia major active disease Cluster 284: nci institute national ctcae grade common terminology cancer adverse events Cluster 285: platelet count 10 100 109 75 50 transfusion days ul Cluster 286: transfusions red blood hemoglobin dl rbc cell receive transfusion platelet Cluster 287: times bilirubin upper normal limit total uln gilbert institutional syndrome Cluster 288: second malignancy active currently cancers melanoma skin considered cancer years Cluster 289: radiation therapy prior weeks chemotherapy treatment patients received surgery study Cluster 290: white wbc blood cell ul cells 000 count 2000 mm Cluster 291: longer whichever half lives investigational drug days study prior treatment Cluster 292: platelets 100 000 mcl mm 10 cells days registration plt Cluster 293: investigational agent study treatment weeks device participated currently drug receiving Cluster 294: 3000 white wbc blood mm cells cell count ul days Cluster 295: metastatic disease evidence patients distant recurrent prior chemotherapy unresectable therapy Cluster 296: cardiovascular significant disease clinically uncontrolled history including pulmonary evidence conditions Cluster 297: surgical resection patients prior biopsy candidate disease surgery procedure patient Cluster 298: recist measurable disease v1 version criteria defined lesion according evaluable Cluster 299: heart york association new myocardial class infarction angina failure cardiac