Alkaline phosphatase =< 2.5 x ULN (CTCAE v 3.0 grade 0-1) Alkaline phosphatase within upper limits of institutional normal within 14 days prior to study entry Alkaline phosphatase less than or equal to 2.5 x ULN (CTCAE grade 1) Alkaline phosphate =< 3 x normal Alkaline phosphatase =< 3 x ULN Alkaline phosphatase =< 1.5 x IULN within 28 days prior to registration Serum alkaline phosphatase (ALP) > 2 x ULN Alkaline phosphatase less than or equal to 2.5 x ULN Alkaline phosphatase =< 1.5 x institutional ULN, within 21 days prior to registration Alkaline phosphatase (ALP) =< 2.5 x ULN measured within 28 days prior to randomization Patients must have alkaline phosphatase =< 2.5 x IULN within 14 days prior to registration Alkaline phosphatase =< 2 x ULN (=< 5 x ULN for patients with known liver involvement and =< 7 x ULN for patients with known bone involvement) Alkaline phosphatase =< 2 x ULN (=< 5 x ULN for patients with known liver involvement and =< 7 x ULN for patients with known bone involvement) Within 6 weeks prior to randomization: Alkaline phosphatase must be =< 2.5 x ULN for the lab Albumin, alkaline phosphatase, bicarbonate, blood urea (BUN), chloride, glucose, phosphorus, and total protein must be assessed within 28 days of registration Patients must have blood urea nitrogen (BUN), alkaline phosphatase, sodium, potassium, calcium, glucose, chloride, and bicarbonate levels obtained within 14 days prior to registration Alkaline phosphatase =< 2.5 x ULN, within 14 days prior to registration Alkaline phosphatase must be =< 3 x ULN for the lab within 28 days before randomization Alkaline phosphatase =< 2.5 x ULN (=< 5 x ULN for patients with documented liver involvement or bone metastases) Alkaline phosphatase =< 2 x IULN Alkaline phosphatase =< 2.5 x ULN (=< 5 x ULN for patients with documented liver involvement or bone metastases) Alkaline phosphatase =< 2.5 x ULN Alkaline phosphatase =< 2.5 x ULN Alkaline phosphatase =< 2.5 x IULN, obtained within 28 days prior to step 2 registration Alkaline phosphatase =< 2 x ULN (=< 5 x ULN for patients with documented liver involvement or bone metastases)