Neuropathy (sensory and motor) =< CTCAE v 3.0 grade 1 Neuropathy (sensory and motor) less than or equal to CTCAE grade 1 Peripheral neuropathy of severity greater than grade 1 Grade 2 or greater neuropathy Grade 2 or greater peripheral neuropathy Patients must not have grade 2 or greater peripheral sensory neuropathy RANDOMIZED PHASE II (ARMS K AND L): Patients must not have grade 2 or greater peripheral sensory neuropathy Patients must have < grade 2 neuropathy (sensory/motor) within 7 days prior to registration =< grade 2 peripheral neuropathy RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2): =< grade 2 peripheral neuropathy Peripheral neuropathy =< grade 1 at the time of registration >= Grade 2 peripheral sensory neuropathy (CTCAE, v. 4.0) No grade 2 or higher neuropathy Sensory/motor neuropathy >= grade 2 Pre-existing >= grade 2 sensory or motor peripheral neurotoxicity Sensory/motor neuropathy >= grade 2 Grade 3 or higher peripheral neuropathy Patients must not have peripheral neuropathy >= grade 2 Patients must not have peripheral neuropathy > grade 2 Grade >= 2 peripheral neuropathy Peripheral neuropathy of severity greater than grade 1 Nervous system disorder (paresthesia, peripheral motor neuropathy, or peripheral sensory neuropathy) >= grade 2, per the Common Terminology Criteria for Adverse Events (CTCAE) version (v)4.0 Patients with neuropathy > grade 1 =< grade 2 peripheral neuropathy; patients with grade 1 peripheral neuropathy with pain will be excluded Central nervous system (CNS) toxicity including peripheral neuropathy =< grade 2 Patients must have recovered from adverse events attributable to previous treatment to =< grade 1, except for alopecia and sensory neuropathy =< grade 2 Patients with grade >= 2 peripheral neuropathy will not be permitted on study Patients must have recovered from adverse events attributable to previous treatment to =< grade 1, except for alopecia and sensory neuropathy =< grade 2 Patients must have recovered from adverse events attributable to previous treatment to =< grade 1, except for alopecia and sensory neuropathy =< grade 2 Patients with >= grade 2 neuropathy Patients must not have baseline peripheral neuropathy that exceeds grade 1 Sensory or motor neuropathy >= grade 2 No grade >= 2 neuropathy No grade >= 2 peripheral motor or sensory neuropathy