Karnofsky performance status >= 60 within 21 days prior to study entry Karnofsky performance status > 30% (given the aggressiveness of this disease and the often severely debilitated nature of the patients at initial presentation) Karnofsky performance status >= 60% Patients must have a Karnofsky performance status >= 60% (i.e. the patient must be able to care for himself/herself with occasional help from others) Karnofsky performance status >= 60% TUMOR BIOPSY SEQUENCING: Karnofsky performance status >= 70% TREATMENT: Karnofsky performance status >= 70% Patients must have a Karnofsky performance status >= 60% (i.e. the patient must be able to care for himself/herself with occasional help from others) Karnofsky performance status >= 70 within 28 days prior to step 2 registration Patients must have a Karnofsky performance status >= 60% (i.e. the patient must be able to care for himself/herself with occasional help from others) Karnofsky performance status >= 70% Karnofsky performance status of >= 70 within 28 days prior to Step 2 registration ECOG performance status =< 2 (Karnofsky >= 60 %) Patients must have a Karnofsky performance status (KPS) >= 60% (i.e. the patient must be able to care for himself/herself with occasional help from others) Karnofsky performance status >= 60% Karnofsky performance status >= 60 Karnofsky performance score >= 70 Karnofsky performance status >= 60 Patients must have a Karnofsky performance status >= 60% (i.e. the patient must be able to care for himself/herself with occasional help from others) Patients must have a Karnofsky performance status >= 60% (i.e. the patient must be able to care for himself/herself with occasional help from others) History and physical exam, and Karnofsky performance status of >= 70 within 30 days prior to registration