REGISTRATION #2 - PRIOR TO CONSOLIDATION CHEMOTHERAPY: Total bilirubin =< IULN
REGISTRATION #2 - PRIOR TO CONSOLIDATION CHEMOTHERAPY: SGOT (AST) or SGPT (ALT) =< 2.5 x IULN
Serum creatinine =< 2 x institutional upper limit of normal (IULN), unless due to lymphoma, within 42 day prior to registration
Total bilirubin =< 2 x institutional upper limit of normal (IULN) (unless due to Gilbert syndrome) within 42 days prior to registration
Serum creatinine level =< IULN within 28 days prior to registration
Within 14 days prior to registration: Total bilirubin =< 1.5 x institutional upper limit of normal (IULN)
Serum creatinine =< 1.5 x IULN obtained within 28 days prior to registration
Patients must have serum creatinine =< 2 x institutional upper limits of normal (IULN) within 7 days prior to registration
Patients must have bilirubin =< 2 x IULN within 7 days prior to registration (unless the bilirubin is primarily unconjugated)
Serum bilirubin =< institutional upper limit of normal (IULN) within 28 days prior to sub-study registration; for patients with liver metastases, bilirubin must be =< 5 x IULN
Patients must have total bilirubin =< 2.0 x IULN within 14 days prior to registration
AST and ALT =< 3.0 x institutional upper limit of normal (IULN) within 14 days prior to registration
Total bilirubin =< 2.0 x IULN within 14 days prior to registration
Registration Step 3  Maintenance: Patients must have AST and ALT =< 3.0 x institutional upper limit of normal (IULN) within 14 days prior to registration
Registration Step 3  Maintenance: Patients must have total bilirubin < 2.0 x institutional upper limit of normal (IULN) within 14 days prior to registration
Obtained within 28 days prior to registration: Total bilirubin =< 1.5 x institutional upper limit of normal (IULN)
Serum creatinine =< IULN within 14 days prior to registration
Patients must have adequate renal function with serum creatinine level =< IULN within 21 days prior to registration
Within 14 days prior to registration: Total bilirubin =< 1.5 x institutional upper limit of normal (IULN)
CLINICAL/LABORATORY CRITERIA: Total bilirubin =< 1.5 x institutional upper limit of normal (IULN); these results must be obtained within 28 days prior to registration
Obtained within 28 days prior to registration: Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (or =< 3.0 x IULN with Gilbert's syndrome)
Within 28 days prior to registration: Total bilirubin =< 2.0 x institutional upper limit of normal (IULN) or for documented/suspected Gilberts disease, total bilirubin =< 3.0 x IULN
Within 28 days prior to registration: Serum creatinine =< 2.0 x IULN
Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (except Gilberts syndrome, who must have a total bilirubin < 3.0 mg/dL), obtained within 28 days prior to step 2 registration
Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) except patients with documented Gilberts syndrome within 28 days prior to registration
Serum creatinine < 2.0 x IULN within 28 days prior to registration
Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (=< 5 x IULN if secondary to lymphoma, Gilberts syndrome, or medication related [e.g., indinavir, tenofovir, atazanavir]) within 28 days prior to registration
Direct bilirubin =< 1.5 x IULN (=< 5 x IULN if secondary to lymphoma) within 28 days prior to registration
Total bilirubin =< 2.5 x institutional upper limit of normal (IULN) (except patients with Gilberts syndrome) within 28 days prior to registration
Serum creatinine =< 2.0 x IULN within 28 days prior to registration