Bilirubin less than or equal to 1.5 x upper limit of normal (ULN) (CTCAE grade 1) Bilirubin* =< 2 x upper limit of normal* In the absence of Gilberts disease Bilirubin =< 1.5 x normal Bilirubin =< 3.0 x upper limit of normal (ULN) TREATMENT: Bilirubin =< 2 x upper limit of normal Serum bilirubin > 1.5 x upper limit of normal (ULN) Total bilirubin must be < 1.5 x the upper limit of normal, unless the elevation of bilirubin is thought to be secondary to Gilberts syndrome or combined antiretroviral therapy (cART); if, however, the elevated bilirubin is felt to be secondary to antiretroviral therapy, the total bilirubin must be =< 3.5 mg/dL, provided that the direct bilirubin is normal and the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x the upper limit of normal; also, if the elevated bilirubin is thought to be secondary to cHL the same criteria for hyperbilirubinemia should be applied; however 1 prior cycle of cyclophosphamide is permitted in attempt to make the participant eligible; patients should not be excluded from study participation unless dosing cannot be safely established Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (unless due to Gilberts disease or disease-related hemolysis, then =< 3.0 x ULN) Bilirubin < 1.5 x upper limit of normal (ULN) Bilirubin =< 2 x upper limit of normal (ULN) (unless documented Gilberts syndrome, for which bilirubin =< 3 x upper limit of normal [ULN] is permitted) obtained within 2 weeks prior to registration RANDOMIZED PHASE II (ARMS K AND L): Bilirubin =< 2 x upper limit of normal (ULN) (unless documented Gilberts syndrome, for which Bilirubin =< 3 x upper limit of normal [ULN] is permitted); obtained within 2 weeks prior to registration Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (or =< 2.5 x ULN for patients with Gilberts syndrome) Serum bilirubin =< 1.5 x institutional upper limit of normal (ULN) except subjects with known Gilberts syndrome Bilirubin =< 1.5 x institutional upper limit of normal (ULN) except subjects with known Gilberts syndrome, within 2 weeks of the first dose of study treatment Bilirubin less than or equal to 1.5 x institutional/laboratory upper limit of normal (ULN) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (patients with Gilberts syndrome may have serum bilirubin > 1.5 ULN) Total bilirubin =< 1.5 x institutional upper limit of normal; unless due to Gilberts syndrome Bilirubin =< 1.5 times upper limit of normal Bilirubin =< 1.5 x upper limit of normal (ULN) Total bilirubin < 1.5 x institutional upper limit of normal (=< 3 mg/dL in case of Gilberts syndrome) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (or =< 2.5 x ULN with Gilberts disease) Total bilirubin =< 1.5 x ULN (institutional upper limit of normal) (patients with Gilberts syndrome may have direct bilirubin > 2.5 x ULN) Bilirubin =< 1.5 upper limit of normal (ULN) Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (or =< 2.5 x upper limit of normal [ULN] with Gilberts syndrome) Total bilirubin =< 1.5 x upper limit of normal (ULN) (unless Gilberts syndrome or disease infiltration of the liver is present) Bilirubin =< 1.5 x ULN upper limit of normal (except in patients with documented Gilberts disease, who must have a total bilirubin =< 3.0 mg/dL), must be obtained within 8 weeks prior to screening for protocol therapy Serum bilirubin =< 1.5 x institutional upper limit of normal (ULN) except subjects with known Gilberts syndrome Total bilirubin =< 1.25 x institutional upper limit of normal (ULN), with the exception of < 2.9 mg/dL for patients with Gilberts disease Within 2 weeks prior to screening step registration and within 4 weeks prior to treatment step registration: Total bilirubin =< 1.5 X institutional upper limit of normal (ULN) (unless documented Gilberts syndrome, for which bilirubin =< 3 x institutional ULN is permitted) Total bilirubin =< 1.5 x upper limit of normal (ULN); except in case of Gilberts disease Total bilirubin =< 1.5 x upper limit of normal (ULN) unless isolated hyperbilirubinemia attributed to Gilberts syndrome Total bilirubin =< 1.5 x institutional upper limit of normal (ULN); an exception to this may be allowed for participants with Gilberts syndrome with documented approval by the protocol chair Total bilirubin =< 1.5 x upper limit of normal (ULN) (patients with Gilberts syndrome may have serum bilirubin > 1.5 ULN) Total bilirubin =< 1.5 x upper limit of normal (ULN), unless due to Gilberts syndrome or hemolysis, in which case =< 3.0 x ULN is allowed Total bilirubin < 1.5 X upper limit of normal (ULN); or < 3 x institutional ULN for Gilberts syndrome or HIV protease inhibitors; or < 5 x ULN and direct bilirubin < 0.7 mg/dL for patients on atazanavir containing HIV regimen Bilirubin =< 1.5 x upper limit of normal (ULN), within 14 days prior to registration Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (however, patients with known Gilbert disease who have serum bilirubin level =< 3 x ULN may be enrolled) Total bilirubin =< 1.5 x upper limit of normal (ULN) (however, patients with known Gilbert disease who have serum bilirubin level =< 3 x ULN may be enrolled) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (however, patients with known Gilbert disease who have serum bilirubin level =< 3 x ULN may be enrolled) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (however, patients with known Gilbert disease who have serum bilirubin level =< 3 x ULN may be enrolled) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (however, patients with known Gilbert disease who have serum bilirubin level =< 3 x ULN may be enrolled) Serum bilirubin =< 1.5 x institutional upper limit of normal (ULN) (except patients with Gilberts syndrome, who can have total bilirubin < 3 mg/DL) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN), (except for patients with known Gilberts syndrome who must have normal direct bilirubin) Direct bilirubin =< 3 x upper limit of normal (ULN), unless suspected leukemic involvement of the liver Total bilirubin =< 1.5 x upper limit of normal (ULN), except for patients with known Gilberts syndrome Bilirubin =< 1.5 upper limit of normal (ULN) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) within 30 days of day 1 of study; NOTE: patients with elevated bilirubin secondary to Gilberts disease are eligible to participate in the study Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (however, patients with known Gilbert disease who have serum bilirubin level =< 3 x ULN may be enrolled)