Patients with a life expectancy of less than one year Life expectancy >= 12 weeks Life expectancy > 3 months Life expectancy >= 3 months PROCUREMENT: Patients with life expectancy >= 6 weeks TREATMENT: Patients with life expectancy >= 6 weeks Life expectancy of > 3 months Participants must have an estimated life expectancy of > 6 weeks Patients must have a life expectancy of at least 6 weeks Life expectancy >= 12 weeks Life expectancy > 3 months Life expectancy of at least 6 months Life expectancy > 3 months Life expectancy of less than 3 months TUMOR BIOPSY SEQUENCING: Life expectancy > 3 months TREATMENT: Life expectancy > 3 months Patients must have a life expectancy of >= 8 weeks Patients must have a life expectancy >= 12 weeks Life expectancy of > 3 months Patient must have a life expectancy of at least 3 months with appropriate therapy Patients must have a life expectancy of at least 8 weeks Participants must have a life expectancy of 2 years or more Life expectancy must be estimated by patients physician at > 6 months Patients must have a life expectancy of >= 12 weeks as determined clinically by the treating physician Life expectancy > 3 months Life expectancy of > 2 months Life expectancy of >= 4 months No comorbid conditions that would cause life expectancy of less than 5 years Life expectancy > 12 weeks Patients must have a life expectancy of >= 2 months Life expectancy > 3 months Patients must have a life expectancy of >= 8 weeks Must have a life expectancy of at least 12 weeks Patient must have a life expectancy of at least 3 months with appropriate therapy Life expectancy of at least 3 months Life expectancy > 6 months as assessed by study physician