Total bilirubin < 2 x institutional upper limit of normal (ULN) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) obtained =< 21 days prior to registration Total bilirubin < 1.5 x upper limit of normal assessed within seven (7) days prior to the start of therapy Total bilirubin within institutional upper limit of normal (IULN) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN); =< 3 x institutional ULN if the patient has Gilbert's syndrome Total bilirubin =< 2 x institutional upper limit of normal Bilirubin < 1.5 times institutional upper limit of normal, within 21 days prior to study entry Total bilirubin =< 1.5 institutional upper limit of normal (ULN) Obtained =< 7 days prior to registration: Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) Total bilirubin < 2 x the institutional upper limit of normal (ULN) Total bilirubin < 2 x institutional upper limit of normal (ULN) within 14 days prior to registration Total bilirubin < 1.5 x institutional upper limit of normal Total bilirubin =< institutional upper limit of normal Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) Total bilirubin =< 1.5 X institutional upper limit of normal Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) Total bilirubin < 1.5 X institutional upper limit of normal Total bilirubin within =< 1.5 x institutional upper limit of normal Total bilirubin =< 1.5 x institutional upper limit of normal TUMOR BIOPSY SEQUENCING: Total bilirubin < 1.5 x institutional upper limit of normal TREATMENT: Total bilirubin < 1.5 x institutional upper limit of normal Total bilirubin =< x 1.5 upper limit of institutional normal Total bilirubin =< 1.5 within 30 days prior to registration* It is highly recommended but not required that total bilirubin be =< 1.5 upper limit of normal Total bilirubin =< 1.5 x institutional upper limit of normal OR > 1.5 x institutional upper limit of normal allowed if direct bilirubin is within normal range Total bilirubin =< 1.5 x institutional upper limit of normal Total bilirubin < 1.5 x institutional upper limit of normal OR > 1.5 x institutional upper limit of normal allowed if direct bilirubin is within normal range Total bilirubin =< 1.5 x institutional upper limit of normal (ULN), within 21 days prior to registration Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) Total bilirubin =<1.5 x institutional upper limit of normal (IULN) Total bilirubin > 2 times the upper limit of normal Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) Total bilirubin =< 1.5 x institutional upper limit of normal Total bilirubin =< institutional upper limit of normal Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (except patients with Gilbert syndrome, who can have total bilirubin < 3.0 mg/dL) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (except patients with Gilbert syndrome, who can have total bilirubin < 3.0 mg/dL) Total bilirubin =< 1.5 times institutional upper limit of normal (ULN) INCLUSION CRITERIA FOR STRATUM C: Total bilirubin =< 1.5 times institutional upper limit of normal (ULN) Total bilirubin =< 1.5 x institutional upper limit of normal Total bilirubin =< institutional upper limit of normal Total bilirubin =< institutional upper limit of normal (ULN) or =< 1.5 X institutional ULN (if the patient has liver metastases) Total bilirubin =< 1.5 x institutional upper limit of normal Total bilirubin less than or equal to the institution's upper limit of normal Total bilirubin =< 1.5 x institutional upper limit of normal Total bilirubin =< 1.5 x the institutional upper limit of normal (ULN) Total bilirubin =< 1.5 X institutional upper limit of normal Total bilirubin =< 1.5 institutional upper limit of normal Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) Total bilirubin =< 1.5 x institutional upper limit of normal Total bilirubin within institutional upper limit of normal Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (except patients with Gilbert syndrome, who can have total bilirubin < 3.0 mg/dL) RECURRENT/ PROGRESSIVE DIPG (STRATUM 1): Total bilirubin =< 1.5 times institutional upper limit of normal (ULN) NON-PROGRESSED DIPG (STRATUM 2): Total bilirubin =< 1.5 times institutional upper limit of normal (ULN) Total bilirubin below normal institutional upper limit of normal (ULN) Total bilirubin =< 1.5 X institutional upper limit of normal Total bilirubin =< 1.5 times institutional upper limit of normal (ULN) Total bilirubin < 1.5 x institutional upper limit of normal (with the exception of those with Gilbert syndrome Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (except Gilbert's syndrome, who must have a total bilirubin < 3.0 mg/dL) Within 28 days prior to administration of study treatment: Total bilirubin =< 1.5 x the institutional upper limit of normal (ULN) Within less than or equal to 14 days prior to registration: Total serum bilirubin =< institutional upper limit of normal (ULN) Within 28 days prior to administration of therapy: Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) Serum total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (patients with Gilbert's syndrome with a total bilirubin < 3.0 mg/dL) Total bilirubin < 4 x institutional upper limit of normal (ULN) Total bilirubin =< institutional upper limit of normal