Radiation: patients must have:* Had their last fraction of local irradiation to primary tumor >= 12 months prior to registration; investigators are reminded to review potentially eligible cases to avoid confusion with pseudo-progression* Had their last fraction of craniospinal irradiation (> 24 Gy) > 3 months prior to registration
At least 14 days after local palliative radiation therapy (XRT) (small port); at least 150 days must have elapsed if prior traumatic brain injury (TBI), craniospinal XRT or if >= 50% radiation of pelvis; at least 42 days must have elapsed if other substantial bone marrow radiation, including therapeutic doses of Iobenguane (MIBG)
Radiotherapy: patients must have had their last fraction of: * Focal irradiation > 2 weeks prior to enrollment
Patients with prior TBI, craniospinal XRT and/or those with >= 50% radiation of the pelvis are not eligible
Patients must have had their last fraction of:* Craniospinal irradiation >= 3 months prior to enrollment* Other substantial bone marrow irradiation >= 6 weeks prior to enrollment* Local palliative radiation therapy (XRT) (small port) >= 2 weeks
INCLUSION CRITERIA FOR STRATUM C: Patients must have had their last fraction of:* Craniospinal irradiation >= 3 months prior to enrollment* Other substantial bone marrow irradiation >= 6 weeks prior to enrollment* Local palliative radiation therapy (XRT) (small port) >= 2 weeks
Patients must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to entering this study* Myelosuppressive anti-cancer therapy: must not have been received within 2 weeks of study entry (4 weeks if prior nitrosourea)* Biologic (anti-neoplastic agent): at least 7 days since the completion of therapy with a biologic agent* Radiation therapy (RT): >= 2 weeks for local palliative radiation therapy (RT) (small port); >= 6 weeks must have elapsed if prior craniospinal RT or if >= 50% radiation of pelvis; >= 6 weeks must have elapsed if other substantial bone marrow (BM) radiation* Surgery: >= 2 weeks from last major surgery, including pulmonary metastasectomy, with the exclusion of a central line placement and core needle or small open biopsies
Radiation therapy (RT): >= 2 weeks for local palliative RT (small port); >= 6 months must have elapsed if prior craniospinal RT or if >= 50% radiation of pelvis; >= 6 weeks must have elapsed if other substantial bone marrow (BM) radiation; Note: patients must have received =< than 13.6 Gray (Gy) prior radiation to the mediastinum
RECURRENT/ PROGRESSIVE DIPG (STRATUM 1): Patients must have had their last fraction of: * Craniospinal irradiation or radiation to >= 50% of pelvis > 3 months prior to enrollment* Focal irradiation to the primary site > 42 days prior to enrollment* Local palliative irradiation other than previously irradiated primary site (small port) >= 14 days
NON-PROGRESSED DIPG (STRATUM 2): Patients must have had their last fraction of focal irradiation to the primary site > 14 days prior to enrollment; patients must not have received local palliative irradiation or craniospinal irradiation
Patients must have had their last fraction of: * Craniospinal irradiation (> 24 Gy) > 3 months prior to enrollment* Focal irradiation > 42 days prior to enrollment* Local palliative irradiation (small port) > 14 days
>= 2 weeks must have elapsed since local palliative radiation therapy (XRT) (small port); >= 6 weeks must have elapsed since treatment with therapeutic doses of M-Iodobenzylguanidine (MIBG); >= 3 months must have elapsed if prior craniospinal XRT was received, if >= 50% of the pelvis was irradiated, or if total-body irradiation (TBI) was received; >= 6 weeks must have elapsed if other substantial bone marrow irradiation was given* Subjects should not have any clinically relevant ongoing complications from prior radiation therapy (i.e., radiation esophagitis or other inflammation of the viscera)
X ray (XRT)/external beam irradiation including protons: >= 14 days after local XRT; >= 150 days after TBI, craniospinal XRT or if radiation to >= 50% of the pelvis; >= 42 days if other substantial bone marrow (BM) radiation