Willingness to avoid the ingestion of grapefruit and Seville oranges (as well as other products containing these fruits, e.g. grapefruit juice or marmalade) during the study, as these may affect selumetinib metabolism Serious hypersensitivity reaction to egg products Patients with known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies Willingness to avoid the ingestion of grapefruit and Seville oranges (as well as other products containing these fruits, e.g. grapefruit juice or marmalade) during the study Patients with known sensitivity to any of the products to be administered during the study (eg, mammalian derived products, calcium or vitamin D) Known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies Known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies Willingness to avoid the ingestion of grapefruit and Seville oranges (as well as other products containing these fruits, e.g. grapefruit juice or marmalade) during the study Willingness to avoid the ingestion of grapefruit and Seville oranges (as well as other products containing these fruits, e.g. grapefruit juice or marmalade) during the study, as these may affect selumetinib metabolism Patients must not be known to be allergic to Chinese hamster egg or ovaries Known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies Known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies Known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies No known hypersensitivity to Chinese hamster ovary (CHO) cell products or any component of the atezolizumab formulation Known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies Patients with known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies Known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies