Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial; previously treated brain metastases, neurologically stable, and no ongoing or anticipated need for steroid therapy are eligible Patients with known brain metastases should be excluded from early clinical trials Patients with clinically or radiologically unstable brain metastases are excluded from this clinical trial* Note: patients with stable brain metastases after treatment, for at least 3 months prior to enrolling on this trial, could participate in the study; patients should be off, or on a stable dose of steroids Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Participants with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases are excluded Patients with known brain metastases should be excluded from this clinical trial; a scan to confirm the absence of brain metastasis is not required Patients with known brain metastases should be excluded from this clinical trial Participants with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events Patients with known brain metastases should be excluded from this clinical trial except as those described below Patients with known active or history of brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial