Subject has a history of unexplained loss of consciousness or transient ischemic attack within 12 months of treatment start loss of consciousness or transient ischemic attack within 12 months of randomization History of seizure or any condition that may predispose to seizures at any time in the past. History of loss of consciousness or transient ischemic attack within 12 months of screening History of loss of consciousness or transient ischemic attack within twelve (12) months of enrollment History of loss of consciousness or transient ischemic attack within 12 months prior to enrollment Any history of seizure; history of loss of consciousness or transient ischemic attack within 12 months of starting the study drug Subject with a history of loss of consciousness or transient ischemic attack ? 12 months of study drug initiation. For Cohort C: Has a history of loss of consciousness within 12 months of the screening visit Subject has history of loss of consciousness or transient ischemic attack within 12 months prior to day 1. The subject has a history of loss of consciousness, cerebrovascular accident, or transient ischemic attack within 12 months before the Day 1 visit. Subject has a history of loss of consciousness or transient ischemic attack within 12 months before the Day 1 visit. loss of consciousness or transient ischemic attack within 12 months of randomization History of loss of consciousness or transient ischemic attack within 12 months prior to enrollment unexplained loss of consciousness within the last 12 months, For Arm D only: History of seizure, unexplained loss of consciousness, transient ischemic attack within 12 months of enrollment, cerebral vascular accident, and any brain metastases History of loss of consciousness or transient ischemic attack within 12 months of enrollment History of stroke or head injury associated with loss of consciousness within 12 months of registration History of loss of consciousness or transient ischemic attack within past 12 months History of stroke or transient ischemic attack Subjects with prior history of myocardial infarction, transient ischemic attack, or stroke in the last 6 months History of arterial thrombosis (eg, stroke or transient ischemic attack) within 12 months of first dose of AMG 757 History of arterial thrombosis (eg, stroke or transient ischemic attack) in the past 3 months. History of stroke or transient ischemic attack within the previous 6 months History of stroke, reversible ischemic neurological defect, or transient ischemic attack within 6 months prior to Day 1 History of stroke, reversible ischemic neurological defect, or transient ischemic attack within 6 months prior to initiation of study treatment History of stroke or transient ischemic attack within 6 months prior to registration History of arterial thrombosis (eg, stroke or transient ischemic attack) in the past 3 months Infection requiring intravenous antibiotics within 1 week of study enrollment (day 1) History of stroke or transient ischemic attack within 6 months prior to day 1 History of arterial thrombosis (eg, stroke or transient ischemic attack) within 12 months of enrollment. History of stroke or transient ischemic attack within 6 months of the randomization History of stroke, reversible ischemic neurological defect, or transient ischemic attack within 6 months prior to Day 1 Symptomatic carotid artery disease, as manifested by a recent transient ischemic attack (within 30 days), ischemic stroke, or amaurosis fugax (monocular visual ischemic symptoms or blindness). Cerebrovascular disease manifested as prior stroke at any time or transient ischemic attack (TIA) in the 12 months prior to initiation of therapy History of stroke or transient ischemic attack within 6 months prior to registration History of stroke or transient ischemic attack within 3 months prior to cycle 1, day 1 History or presence of serious hemorrhage , hemoptysis or hematemesis within 3 months or a thromboembolic event (including Deep Vein Thrombosis (DVT), stroke and/or transient ischemic attack) within 6 months; Patients with squamous Non Small Cell Lung Cancer (NSCLC) should be excluded. Cerebrovascular event (transient ischemic attack, stroke or CNS bleeding) within the last 12 months. History of stroke or transient ischemic attack within six months History of stroke or transient ischemic attack within 6 months prior to study enrollment History of stroke or transient ischemic attack within 6 months prior to day 1 History of transient ischemic attack (TIA) or stroke within 6 months of study entry Stroke within 6 months of screening, or transient ischaemic attack (TIA) within 3 months of screening 215 History of arterial thrombosis (eg, stroke or transient ischemic attack) within 12 months of first dose of AMG 562. History of transient ischemic attack within the previous 6 months History of stroke or transient ischemic attack =< 6 months prior to registration History of stroke or transient ischemic attack within six months History of stroke or transient ischemic attack within 6 months prior to Day1 History of stroke or transient ischemic attack within 6 months prior to study enrollment History of stroke or transient ischemic attacks within 6 months prior to study enrolment. Patients are excluded if they have a history of stroke or transient ischemic attack within 6 months prior to randomization History of stroke or transient ischemic attack within 6 months prior to cycle 1, day 1 History of stroke, cerebral vascular accident (CVA) or transient ischemic attack within 6 months prior to registration History of stroke, cerebral vascular accident (CVA) or transient ischemic attack within 6 months History of stroke or transient ischemic attack within 6 months History of stroke or transient ischemic attack within 6 months prior to beginning treatment. History of stroke or transient ischemic attack, or other arterial thrombosis =< 12 months prior to randomization Participants may not have had a history of a stroke or transient ischemic attack within six months History of stroke, cerebral vascular accident (CVA) or transient ischemic attack within 6 months Patients must have not have a history of hemorrhagic or ischemic stroke, including transient ischemic attacks and other central nervous system bleeding in the preceding 6 months that were not related to glioma surgery Stroke or transient ischemic attack Myocardial infarction and transient ischemic attack or stroke within 6 months prior to enrollment History of a stroke or transient ischemic attack within 6 months - History of stroke or transient ischemic attack within 6 months prior to Day 1. History of significant cerebrovascular disease (i.e. stroke or transient ischemic attack [TIA]) in the past 6 months or ongoing event with active symptoms or sequelae History of stroke or transient ischemic attack within 6 months prior to day 1 Prior history of stroke or transient ischemic attack within 6 months prior to day -3 History of stroke or transient ischemic attack History of stroke or transient ischemic attack within six months History of stroke or transient ischemic attack (TIA) within 6 months prior to Cycle 1, Day 1 History of stroke or transient ischemic attack within 6 months prior to Day 1 Past history of stroke or transient ischemic attack requiring medical therapy Symptomatic peripheral vascular disease, stroke or transient ischemic attack within 6 months History of stroke or transient ischemic attack within 3 months prior to registration History of stroke or transient ischemic attack within 6 months prior to beginning treatment. History of stroke or transient ischemic attack within 6 months prior to study enrollment History of stroke or transient ischemic attack within 6 months prior to day 1 History of stroke or transient ischemic attack within 3 months of first study dose No history of stroke or transient ischemic attack History of stroke, reversible ischemic neurological defect or transient ischemic attack within 6 months prior to Day 1 History of progressive promyelocytic leukemia (PML), known history of pancreatitis, active grade 3 or higher viral, bacterial or fungal infection =< 2 weeks prior to registration and documented history of cerebrovascular event (stroke or transient ischemic attack [TIA]) =< 6 months prior to registration Stroke or transient ischemic attack within 6 months of screening History of stroke or transient ischemic attack in the preceding 6 months History of stroke/transient ischemic attack History of transient ischemic attack (TIA), cerebrovascular accident (CVA), gastrointestinal (GI) perforation or arterial thrombotic event within 6 months prior to randomization or symptomatic peripheral ischemia Patients with a history of transient ischemic attack (TIA) or cerebrovascular accident (CVA) within the past 6 months prior to study enrollment are NOT eligible for participation Recent serious cardiovascular events (within 12 months) including, but not limited to, transient ischemic attack (TIA), cerebrovascular accident (CVA), or myocardial infarction (MI). History of thromboembolic or cerebrovascular events within the last 6 months, including transient ischemic attack, cerebrovascular accident, deep vein thrombosis, or pulmonary embolism Known active brain or central nervous system metastasis, or seizures requiring anticonvulsant treatment, cerebrovascular accident, or transient ischemic attack (< 6 months prior to enrollment) Cerebral vascular accident (CVA) or transitory ischemic attack (TIA) in the year before enrollment, or presence of residual symptoms from CVA that happened more than a year before Any history of cerebrovascular accident (CVA) or transient ischemic attack within 12 months prior to registration. History of prior cerebrovascular event, (including transient ischemic attack) within 6 months of start of screening Any history of cerebrovascular accident or transient ischemic attack History of thromboembolic or cerebrovascular events within the last 6 months, including transient ischemic attack, cerebrovascular accident, deep vein thrombosis, or pulmonary embolism (applicable to combination part only). Any history of myocardial infarction (MI), unstable angina, cerebrovascular accident, or Transient Ischemic Attack (TIA) PHASE I STUDY ELIGIBILITY CRITERIA:\r\nHistory of cerebrovascular accident, transient ischemic attack within 1 year prior to study enrollment PHASE II COLORECTAL CANCER COHORT 6 (MEDI+C ONLY):\r\nHistory of cerebrovascular accident, transient ischemic attack within 1 year prior to study enrollment Cerebrovascular accident or transient ischemic attack Cerebrovascular accident or transient ischemic attack within 6 months prior to first dose. History of an ischemic insult in the previous 12 months (myocardial infarction, cerebral vascular accident, ischemic tissue from injury, transient ischemic attack) History of seizures except for remote with specific etiology which has resolved (ex: alcohol induced seizure); transient ischemic attack (TIA) or cerebrovascular accident (CVA) within last 6 months History of transient ischemic attack (TIA) or cerebrovascular accident (CVA) Prior history of cerebrovascular accident or transient ischemic attack. Cerebrovascular accident or transient ischemic attack Patients must have international normalized ratio (INR) =< 1.2 within 14 days prior to registration; patients must not be receiving warfarin for therapeutic use, have history of cerebrovascular accident (CVA), history of transient ischemic attack (TIA) requiring intervention or treatment, pre-existing carotid artery disease requiring intervention or treatment, or current use of megestrol acetate (use within 10 days of registration) History or evidence of thrombotic or hemorrhagic disorders; including cerebrovascular accident (CVA)/stroke or transient ischemic attack (TIA) or sub-arachnoid hemorrhage within =< 6 months prior to the first study treatment Cerebrovascular accident (CVA, stroke), transient ischemic attack (TIA) within 6 months prior to the first date of study therapy. Known active brain or central nervous system metastasis (less than 1 month out from definitive radiotherapy or surgery), or seizures requiring anticonvulsant treatment, or clinically significant cerebrovascular accident or transient ischemic attack (< 3 months) Prior history of cerebrovascular accident or transient ischemic attack, or pre-existing carotid artery disease Patients with a cerebrovascular accident or transient ischemic attack within the past six months History of cerebrovascular attack or transient ischemic attack within 6 months prior to the initiation of therapy on this protocol Cerebrovascular accident or transient ischemic attack within 6 months prior to first dose history of cerebrovascular accident (CVA) or transient ischemic attack (TIA), Prior history of cerebrovascular accident or transient ischemic attack History or evidence of thrombotic or hemorrhagic disorders; including cerebrovascular accident (CVA)/stroke or transient ischemic attack (TIA) or sub-arachnoid hemorrhage within =< 6 months prior to the first study treatment History of cerebrovascular accident, including transient ischemic attack (TIA) History of cerebral vascular accident (CVA) or transient ischemic attack (TIA) =< 6 months prior to randomization History of cerebrovascular accident including transient ischemic attack within the past 12 months Patients with cerebrovascular accident or transient ischemic attack within 6 months of therapy are excluded History of cerebrovascular accident or transient ischemic attack. History of an ischemic insult in the previous 12 months (myocardial infarction, cerebral vascular accident, ischemic tissue from injury, transient ischemic attack. History of cerebrovascular attack or transient ischemic attack within 6 months prior to the initiation of therapy on this protocol. History of prior cerebrovascular accident (CVA), including transient ischemic attach (TIA) Cerebrovascular accident or transient ischemic attack within 2 years History of cerebrovascular accident within the past 6 months (e.g. transient ischemic attack [TIA]) History of dementia, Alzheimer’s disease, multi-infarct dementia or cerebrovascular accident (CVA) (history of transient ischemic attack [TIA] is allowed) Cerebrovascular accident (CVA), transient ischemic attack (TIA) within the last 6 months prior to registration History of cerebrovascular accident or transient ischemic attack within 3 months of first study dose Uncontrolled active seizure disorder or history of cerebrovascular accident (CVA) or transient ischemic (TI) attack within the past 12 months Cerebrovascular accident or transient ischemia.