Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 50,000/mcL or recovery to the baseline count Platelets >= 75,000/mcL, within 2 weeks of randomization Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL within 4 weeks before randomization Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL platelets ?100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000 / mcL Platelets ? 100,000/mcl Platelets >= 100,000/mcL (>= 100,000/mm^3) Platelets >= 150,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets =< 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL. Platelets > 100,000/mcL Platelets >= 100,000/mcL Platelets ? 100,000/mcL Platelets ? 100,000 /mcl Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL. Platelets >= 100,000/mcl Platelets >= 50,000/mcL Platelets >= 100,000/mcL Platelets >= 25,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100 K/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets > 100,000/mcL Platelets >= 100,000/mcL MCL Platelets > 100,000/mcL Platelets >= 100,000/mcL Platelets: > 100,000/mcL ARM 2 - A: Platelets: >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 50,000/mcL Platelets >= 100,000/mcL COHORT I: Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets ? 100,000/mcL Platelets >= 100,000/mcL. Platelets >= 100,000/mcL. Platelets ? 100,000/mcL Platelets ? 75,000/mcl Platelets >= 100,000/mcl Platelets at least 75,000/mcL Platelets > 100,000/mcL Platelets >= 75,000/mcL. Platelets ? 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets ? 50,000/mcL Platelets >= 150,000/mcL Platelets >= 50,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL. Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL. Platelets >= 100,000 / mcL. Platelets >= 100,000/mcL Platelets >= 50,000/mcL; >= 25,000/mcL if impairment is due to LPD/NHL (transfusions not permitted) Platelets >= 50,000/mcL (transfusions not permitted) Platelets >= 100,000/mcL Platelets ? 100,000/mcL Platelets >= 100,000/mcL Platelets >= 80,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/ mcL Platelets >= 100,000/mcL Platelets >= 150,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 25,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets > 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 25,000/mcL Platelets >= 100,000 / mcL Platelets >= 90,000/mcL Platelets >= 100,000 / mcL Platelets >= 100,000/mcL Platelets >= 100,000 /mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets > = 100 000 mcL Platelets >= 100,000 /mcL Platelets >= 100,000 /mcL. Platelets >= 100,000 / mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets ? 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000 / mcL Platelets >= 100,000/mcL Platelets: >= 100,000 / mcL Platelets >= 60,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 150,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 50,000/mcL Platelets >= 100,000 / mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 50,000/mcl Platelets >= 100,000/mcL Platelets >= 50,000/mcL Platelets > 75,000/mcL Platelets of 100,000 per mcL or more Platelets >= 50.000/mcL Platelets: >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 75,000/mcL Platelets < 50,000/mcl Platelets >= 100,000/mcl Platelets >= 80,000/mcL Platelets >= 100,000/mcL PHASE I: Platelets > 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets < 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000 /mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/ mcL Platelets >= 100,000/mcL Platelets >= 100,000 /mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 50,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 50,000/mcl Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000 / mcL Platelets >= 100,000/mcl Platelets > 100,000/mcL Platelets >= 100,000/mcL Platelets >= 90,000/mcL Platelets > 125,000/mcL Platelets >= 100,000/mcL Platelets >= 50,000/mcl Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets < 100,000/mcL Platelets >= 20 K/mcL Platelets >= 100,000/mcL Platelets > 100,000/mcl (unless secondary to MCL) Platelets >= 100,000/mcL Within 4 weeks of preregistration: Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100 K/mcL Platelets >= 100,000/mcL Platelets >= 100,000 / mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >100,000/mcL Platelets ? 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets ? 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets > 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000 / mcL Platelets >= 75,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000 /mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL\r\n* Patients whose platelets are >= 50,000/mcL will be allowed on trial if low platelet count is due to lymphoma Platelets >= 100,000 / mcL Platelets >= 100,000/mcL Platelets >= 50,000 cells/mcL (50 x 10^9/L) Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 50,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 50,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcl Platelets >= 75,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets of 100,000 per mcL or more Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets of 100,000 per mcL or more Platelets >= 100,000/mcL Platelets >=100,000/mcL Platelets > 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets > 100,000/mcL Platelets > 50,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets > 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000 /mcL Platelets >= 50,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000 /mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcl Platelets >= 50,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets > 50 K/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 50,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets > 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets greater than 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL PHASE I: Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 80,000/mcL Platelets > 50,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL PART B: Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 50,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 60,000/mcL Platelets >= 100,000/mcL Platelets > 75,000/mcL Platelets >= 100 K/mcL Platelets > 100,000/mcL Platelets > 100,000/mcL Platelets >= 100000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets>= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL MCL Platelets >= 100 K/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL platelets >100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets ? 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 125,000/mcL Platelets > 100,000/mcL Platelets >= 100,000/mcL Platelets ? 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000 /mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000 / mcL Platelets >= 100,000/mcL Platelets >= 100,000 / mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 125,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets > 80,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets < 50,000/mcl Platelets >= 100,000/mcL Platelets > 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 75,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets > 100,000/mcL Platelets ? 100,000/mcl Platelets >= 100,000/mcL Platelets >= 50,000/mcl Platelets >= 100,000/mcL Platelets > 125,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 50,000/mcL Platelets > 100,000/mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100 K/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets > 50 K/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets > 50,000 cells/mcl (cohort 1) Platelets > 50,000 cells/mcl (Cohort 1) Platelets > 50,000 cells/mcl Platelets >= 100,000/mcL (within four weeks prior to the study) Platelets >= 100,000/mcl Platelets >= 100,000 / mcL Platelets >= 100,000/mcl Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets < 100 K/mcL Platelets >= 75,000/mcL Platelets >= 100,000/mcL Platelets >= 75,000/mcL Platelets > 100,000/mcL Platelets >= 50,000/mcL Platelets (PLTs) >= 40,000/mcL Platelets >= 100,000/mcL Platelets >= 50,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 90,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcl Platelets > 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 75 K/mcL Platelets >= 100,000/mcL Platelets < 75 K/mcL Platelets >= 150,000/mcL At the discretion of the operating surgeon, platelets > 100,000/mcl Platelets < 50 K/mcL At the discretion of the physician, platelets > 100,000/mcl Platelets >= 100,000/mcl Platelets ? 100,000/mcL Platelets < 75K/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets ? 150,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 150,000/mcL Platelets > 75,000/mcL Platelets > 100,000/mcL Platelets > 100,000/mcL Platelets >= 80,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000/mcL Platelets >= 100,000 / mcL Platelets >= 100,000/mcL Platelets >= 100,000 /mcL ANC < 1500/ul ANC < 1,500/µL. ANC ? 1000/µL ANC ?1.5 x 10?/L ANC > 1000/µL ANC ? 1,000/?L ANC < 1,500/µL ANC ? 1,500/µl ANC ? 1.5 x 109/L ANC ? 1000/uL ANC >/=1500 cells/mcL (Cohort C) ANC ?1500/mcL ANC ? 1,000/?L ANC <1500/?L ANC >/=1 x10(9)/L and platelets >/=100 x10(9)/L. ANC ?1.0 × 10^9/Liter (L) ANC ? 1.5 x 109/L ANC >= 1000 K/CUMM ANC ? 750/µL (?0.75 x 10^9/L) ANC ?1.5×10^9/L. ANC 1500 cells/?l ANC ? 1.0 x 109/L ANC ?1,500/µl ANC > 1000/mcL Granulocytes (ANC) >= 1,500/mcl ANC ?1.5×10^9/L ANC ?1500/?L ANC ? 1500 /?L ANC ? 1500 cells/µL ANC ? 1.5 x 10?/L COHORT B: ANC >= 1000/uL ANC < 1,000/µL ANC 1000 cells/mL ANC ? 1000/uL ANC < 1,500/µL ANC > 1000 /ml ANC >= 1000/uL ANC > 750 cells/mcl ANC > 1000/uL ANC ? 1,000/?L ANC ?1000/µL ANC ? 1.0 x 10?/L Re-registration: ANC >= 1,500/mm^3 ANC ? 1500/mm3 Must have measurable MM Prior treatment with MM-310 Granulocytes > 1500/mm^3 Measurable (>10mm x 10mm) contrast enhancing disease. ANC must be ? 1500/mm3; Patients with midline shift > 10mm ANC >500/mm3. Patients must have measurable disease, defined as lesions that can be accurately measure in in 2 perpendicular diameters with at least one diameter > 20mm and the other >10mm on conventional CT or MRI or 10mm x 10 mm by spiral CT. PART II: ANC >= 1000 cells/mm^3 ANC >/= 800/mm3, Cohort 8 (PTCL): ANC >/= 1000/mm3 ANC* ? 1500/mm³ (? 1.5 x 10^9/L) Lymphocytes* ? 500/mm³ (? 0.5 x 10^9/L) Patient has at least one (1) measurable papillary LG tumor, evaluated visually, ? 15 mm. The largest lesion should not exceed 15mm. Subjects must not have an MRI defined target tumor that is within 10 mm of skin (defined as volume encompassing first 3 mm from skin surface) Patients with lack of count recovery as defined by ANC > 500 cells/mm^3, non-transfused platelet count > 20,000 K/mm^3 Adequate bone marrow function: white blood cells (WBCs) ? 3,000/mm3, absolute neutrophil count (ANC) ? 1,500/mm3, hemoglobin ? 9 g/dL, and platelets ? 100,000/mm3 Adequate hematology without ongoing transfusional support (hemoglobin > 9 g/dL, ANC > 1,500 per mm3, platelets > 100,000 per mm3). Absolute neutrophil count (ANC) >= 1500/mm^3; (ANC > 1000/mm^3 may be considered in special circumstances such as benign cyclical neutropenia as judged by the investigator and in discussion with the sponsor) Tumor size less than 5 mm Absolute neutrophil count (ANC) >= 1.0 K/cu mm; for subjects with ANC < 1.0 K/cu mm due to significant marrow involvement by MCL, ANC must be > .5 K/cu mm Adequate hematologic function (Platelets ? 60,000/mm3, lymphocytes ? 1,000/mm3, neutrophils ? 750/mm3, hemoglobin ? 10 g/dl). Adequate hematological function, defined as ANC ? 1,500/mm3, Hb ? 9.0 g/dL, and platelet count ? 100,000/mm3. ANC ?1,000/mm^3 (?1.0x10^9/L) Evidence of MM disease progression any time prior to enrollment; progression from smoldering/asymptomatic MM to symptomatic MM is not exclusionary Platelets >= 50,000/mm^3 or >= 30,000/mm^3 in the setting of marrow involvement by disease or splenomegaly due to disease Patients with a ?20mm non-pedunculated colon polyp Hematopoietic Function: WBC ? 2,500/mm3; ANC ? 1000/mm3; Hemoglobin ? 8 g/dL; Platelet count ? 50,000/mm3; Coagulation: INR ? 1.3. Adequate hematologic function (Platelets ? 60,000/mm3, lymphocytes ? 1,000 mm3, neutrophils ? 750/mm3, hemoglobin ? 9.0 g/dl). Adequate hematologic reserve obtained ? 2 weeks prior to entry: leukocytes ? 3,000 mm^3; absolute neutrophil count ? 1500 mm^3; platelets ? 100,000 mm^3 Adequate hematology without ongoing transfusional support (hemoglobin > 9 g/dL, ANC > 1,500 per mm3, platelets > 100,000 per mm3). ANC > 1500/mm3, plt count > 100,000/mm3 ANC ?1500 cells/mm3 Has MM positive for t(11;14). Adequate hematology without ongoing transfusional support (hemoglobin > 8 g/dL, ANC ? 1,500 per mm3, platelets > 100,000 per mm3) Granulocytes >= 1,000/mm^3 A single measurable tumor that is at least 10.0 mm longest diameter (LDi) X 10.0 mm shortest diameter (SDi) and this tumor does not exceed 40.0 mm in LDi or SDi on Screening MRI * one lesion must be ?10 mm and <100 mm in longest diameter, accessible for repeated intratumoral (IT) injection and accessible for baseline and on-treatment biopsies. Patients must have adequate hematologic reserve as evidenced by absolute neutrophil count (ANC) >= 1500/mm^3 and platelets >= 100,000/mm^3 ANC ?1,000/mm^3 (?1.0 x 10^9/L) Suspected tumour on Baseline MRI within 3 mm of the prostatic urethra, or in the prostate apex within 3 mm from the sphincter plane MM diagnostic criteria (all 3 required); ABC count ? 40,000/mm Marrow: Peripheral blood leukocyte count (WBC) < 3000/mm3, absolute neutrophils count ? 1500/mm3, platelets < 75000/mm3, or hemoglobin < 10 gm/dL. ANC: for patients with lymphoma ?750/mm3 (?0.75 × 10^9/L), for patients with advanced solid tumors ?1,000/mm3 (?1.0 × 10^9/L), ANC ? 1,500 / mm3 ANC >= 1000 cells/mm^3 (1.0 x 10^9/L) Identified calcification of 2 mm or more in largest diameter neighboring the rectal wall (in a distance of less than 5 mm) and interfering with the acoustic beam path. Lymphocytes >= 700/mm^3 Patients must have measurable CNS disease, either previously untreated (not counting systemic therapy), or progressed following previous radiation treatment; lesions that have progressed after prior radiosurgery should not be selected as measurable disease if they are suspected of being radionecrosis; the following measurement criteria are required (not counting tumor edema, as visualized by contrast enhanced magnetic resonance imaging [MRI] with slice thickness of 1.5 mm or smaller, unless prospective permission is obtained from the principal investigator [PI] allowing absence of contrast or thicker slices): \r\n* At least one CNS tumor measuring 10 mm or greater in longest diameter, OR \r\n* At least one CNS tumor measuring 5-9 mm in longest diameter, plus one or two additional CNS tumors measuring 3 mm or greater in longest diameter, for which the sum of the longest diameters is equal to or greater than 10 mm; patient may have additional tumors as well PHASE II: Alternatively, with less BM involvement, an ANC >= 1000/mm^3, and platelet count >= 50,000 mm^3 is required Granulocytes >= 1500/mm^3 within 4 weeks of enrollment Less than 10 mm of cervical stromal invasion Gastric or duodenal ulcer (at least 10 mm in size) within 10 mm of expected endoscopy puncture site(s) for photodynamic therapy (PDT) Granulocytes >= 2,500/mm^3 Lymphocytes >= 1000/mm^3 Hb concentration <5.0 mmol/L (<8.0 g/dL); WBC <2x109/L (2000/mm3); platelets <75x109/L (75x103/mm3). Unifocal malignant tumor that does not exceed 20mm in diameter and measures at least 5mm away from the skin and chest wall Cluster of microcalcifications that do not exceed 10 mm in diameter and measures at least 5mm away from the skin and chest wall Neutrophiles <1,500/mm3 ANC >= 1,500/mm^3 Recipients with agnogenic myeloid metaplasia must have at least 2 of the following features:\r\n* Hemoglobin < 10 g/dl, or > 10 g/dl with transfusion dependence\r\n* WBC < 4,000 or > 30,000/mm^3 or requires cytoreductive therapy to maintain\r\n* WBC < 30,000/mm\r\n* Abnormal cytogenetics including +8, 12p- Granulocytes >= 1,000/mm^3 ANC ?1000/mm³ Adequate bone marrow reserve: ANC ?1500/mm3, platelets ?100,000/mm3 ANC >1500 cells/mm3 Patients should have adequate bone marrow function defined as a peripheral WBC >3,000/mm3 with an ANC >1500/mm3 and a platelet count >100,000/mm3. Adequate hematologic function including ANC ? 1200/mm3, Hemoglobin ? 9 g/dL (transfusion is permitted), and platelets ? 100,000/mm3. Patients with non-secretory or hyposecretory MM Patients with nodal disease limited to micrometastases (pN1Mi, > 0.2 mm and =< 2 mm) or isolated tumor cells (pN0i+ < 0.2 mm) ANC of >1000/mm3 ANC of >1000/mm3 independent of G-CSF ANC of >1000/mm3 independent of G-CSF MM diagnostic criteria (all 3 required): Smoldering MM. Smoldering MM. Has a single lesion with a maximum size of ? 12 mm with ? 10 mm of capsular contact as confirmed by MR imaging, Have had at least one prior episode of fever and neutropenia (ANC < 500/mm^3 or expected to fall below < 500/mm^3) during doxorubicin and cyclophosphamide (AC) A single, biopsy-proven SISCCA as defined by the LAST criteria (=< 3 mm depth of invasion, horizontal spread of =< 7 mm, and completely excised with at least 1 mm margin clear of cancer irrespective of the amount of HSIL) documented per investigator assessment in combination with the pathology report within 16 weeks before Segment B enrollment Be periodontally healthy; this is defined as all sites with attachment levels =< 2 mm and probing depths =< 3 mm) and caries-free, as evidenced by a DMF (decayed, missing, filled teeth) index of < 5 Lymphocytes > 500/ mm3 Identified calcification of 2 mm or more in largest diameter neighboring the rectal wall (in a distance of less than 5 mm) and interfering with the acoustic beam path. Cutaneous melanoma with Breslow depth > 1 mm or melanoma Breslow depth of 0.76 – 1.00 mm in setting of ulceration, extensive regression Mitotic rate >= 1/mm^2 Less than 5 mm distance of the tumor margin from a major vessel (> 7 mm in diameter)\r\n* This will not be considered exclusion when irreversible electroporation (IRE) is used ANC ? 1000/mm3 At least 5 mm of tumor on biopsy (can have multiple cores to comprise 5 mm) ANC ? 1500 mm3, platelets ? 100,000/mm3, hemoglobin ? 9 g/dL,