Proteinuria with urinary protein is =< 1+ on dipstick or routine urinalysis, or a 24-hour urine collection for protein < 1000 mg of protein in 24 hours, within 28 days prior to administration of study treatment
Urinary protein is > 1 + on dipstick and the required following 24-hour urine collection shows urinary protein > 2000 mg;
Urinary protein =< 1+ on dipstick or routine urinalysis (if urine dipstick or routine urinalysis is 2+, a 24-hour urine collection for protein must demonstrate < 1000 mg of protein in 24 hours)
Urine protein via dipstick =< 2+ or =< 100 mg/dl
Urinary protein =< 1+ on dipstick or routine urinary analysis (UA); if dipstick or routine UA is >= 2+, a 24-hour urine collection for protein must demonstrate < 1000 mg of protein in 24 hours
Additional inclusion criteria for patients on the arm pembrolizumab plus ramucirumab:\r\n* Urinary protein is < 100 mg/dL on routine urinalysis. If urine routine urinalysis indicates proteinuria >= 100 mg/dL, then a 24-hour urine collection must be performed and must demonstrate urine protein < 2 g to allow the patient to participate in the study.
Urine protein by dipstick <1+ or UPC =< 1.0 by urinalysis
Urinary protein < 2+ by urine dipstick (if dipstick is >= 2+ then a 24-hour urine collection can be done and the patient may enter only if urinary protein is < 2 g per 24 hours)
The patient’s urinary protein is =< 1+ on dipstick or routine urinalysis (urine analysis [UA]; if urine dipstick or routine analysis is >= 2+, a 24-hour urine collection for protein must demonstrate < 1000 mg of protein in 24 hours to allow participation in this protocol)
The patient’s urinary protein is =< 1 positive (+) (=< 30-100 mg/dl) on dipstick or routine urinalysis (urinary analysis [UA]; if urine dipstick or routine analysis is >= 2+ (>=100-300 mg/dl), a 24-hour urine collection for protein must demonstrate < 1000 mg of protein in 24 hours to allow participation in this protocol)
Urine protein < 1+ on dipstick test or routine urinalysis; if the proteinuria on these tests is >= 2+, then a 24-hour urine test must be collected and must demonstrate < 1 g protein in 24 hours to allow participation
Urinary protein < 2+ by urine dipstick (if >= 2+, a 24-hour urine protein must show protein < 2 g per 24 hours)
Proteinuria: if urine dipstick shows 2+ protein, 24 hour urinary protein should be done and be less than =< 2 grams/24 hours
Urinary protein is <2+.
Urine protein/creatinine (UPC) ratio < 0.5 or urine protein =< 1+ on dipstick or routine urinalysis (UA); if UPC >= 0.5 or urine dipstick or routine analysis is >= 2+, a 24-hour urine collection for protein must demonstrate < 1,000 mg of protein in 24 hours to allow participation in the study
Patients whose urinary protein is =< 1+ on a dipstick or routine urinalysis (UA); if routine analysis is > 2+, a 24-hour urine collection for protein must demonstrate < 1000 mg of protein in 24 hours to allow participation in this protocol)
Have urinary protein ?1+ on dipstick or routine urinalysis.
Urinalysis dipstick for urinary protein performed within 28 days prior to randomization must be 0-1+ protein. If urine dipstick result is greater than or equal to 2+ protein, a 24-hour urine protein must be less than 1.0 g/24 hours.
Participant's urinary protein is ? 1+ on dipstick or routine urinalysis (UA); if urine protein ? 2+, a 24-hour urine collection must demonstrate < 1000 milligrams (mg) of protein in 24 hours to allow participation in the study
Urinalysis =< 1+ protein
Urinary protein is <2+ on dipstick or routine urinalysis.
Urinary protein =< 2+ by urine analysis; if urine protein is > 2+ then a 24-hour urine collection can be done and the patient may enter only if urinary protein is < 2 g per 24 hours
Urine protein =< 1+ on dipstick or routine urinalysis; if urine dipstick or routine urinalysis indicates proteinuria >= 2+, then a 24-hour urine must be collected and must demonstrate < 100 mg of protein in 24 hours
Urinary protein =< 100 mg/dL in urinalysis or =< 1+ on dipstick, unless quantitative protein is < 1000 mg in a 24 h urine sample
Quantitative urine protein by dipstick =< 100
Urinary protein < 2+ by urine dipstick; if dipstick is >= 2+ then a 24-hour urine collection can be done and the patient may enter only if urinary protein is < 2 g per 24 hours
Urine dipstick for proteinuria of =< less than 1+; if urine dipstick is > 1+ then a 24 hour urine for protein must demonstrate < 500 mg of protein in 24 hours to allow participation in the study
Urinary protein =< 30 mg/dL in urinalysis or =< 1+ on dipstick, unless quantitative protein is < 1000 mg in a 24 h urine sample
Has urinary protein is ? 1+ on dipstick or routine urinalysis; if urine protein ? 2+, a 24-hour urine collection must demonstrate < 1000 mg of protein in 24 hours to allow participation in the study
Urinary protein is ?1+ on dipstick or routine urinalysis or 24-hour urine demonstrating <1 gram of protein.
Participants having greater than 1+ proteinuria on urinalysis will undergo 24-h urine collection for quantitative assessment of proteinuria. Participants with urine protein greater than or equal to 1 g/24-hour will be ineligible.
Participants with proteinuria >1+ on urinalysis will undergo 24-hour urine collection for quantitative assessment of proteinuria. Participants with urine protein ?1 g/24 hour will be ineligible.
Measurable disease M protein component in serum (at least 0.5 g/dL) and/or urine (if present) (>=0.2 g excreted in a 24 hour collection sample).
Subject has proteinuria defined by the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE version [v] 4.0) grade > 1 at baseline as measured by a urine dipstick (2+ or greater) and confirmed by a 24 hour urine collection (>= 1 g/24 hrs); subjects may be re-screened if proteinuria is shown to be controlled with or without intervention
Documented baseline proteinuria > 1000 mg/day on 24 hour urine collection; only patients with 1+ or greater proteinuria on urinalysis (UA) and a spot urine protein: creatinine ratio of > 0.5 will undergo a 24 hour urine collection for quantitation of proteinuria
Subjects having > 1+ proteinuria on urine dipstick testing will undergo 24 hours (h) urine collection for quantitative assessment of proteinuria; subjects with urine protein >= 1 g/24h will be ineligible
Obtained within 14 days prior to the first study treatment (cycle 1, day 1): urine dipstick for proteinuria < 2+ unless a 24-hour urine protein =< 1g of protein is demonstrated
Within 14 days prior to the first study treatment (cycle 1, day 1): Urine dipstick for proteinuria < 2+ or 24-hour urine protein < 1 g of protein is demonstrated
If uPCR ? 2.0 then a 24-hour urine collection can be performed to qualify. If this is performed to qualify, the protein result must be < 2 g per 24 hours.
> 30 mg/dL on urine analysis; patients with > 30 mg/dL on urine analysis on urine analysis will undergo 24-hour urine collection for quantitative assessment of proteinuria; subjects with 24-hour protein >= 1 g/24 hours will be ineligible
Proteinuria > 2.0 g of protein in a 24-hour urine collection; all patients with 2 protein on dipstick urinalysis at baseline must undergo a 24-hour urine collection for protein
Urine protein > 2+; Patients discovered to have ? 1+ proteinuria on dipstick urinalysis at baseline should undergo a 24-hour urine collection and must demonstrate < 1 g of protein in 24-hour urine;
Urine dipstick for proteinuria < 2+ unless a 24-hour urine protein < 1 g of protein is demonstrated
Proteinuria at baseline; subjects unexpectedly found to have >= 2+ proteinuria on a urine dipstick at baseline should undergo a 24-hour urine which must be an adequate collection and must demonstrate < 2 g of protein/24 hour (hr) to allow participation in the study
Urinalysis: for patients with 2+ proteinuria on urinalysis, 24 hour urine collection should be obtained; 24 hour urine protein should be < 2 grams
Subject has proteinuria defined by the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE v 4.0) grade > 1 at baseline as measured by a urine dipstick (2+ or greater) and confirmed by a 24 hour urine collection (>= 1 g/24 hrs); subjects may be re-screened if proteinuria is shown to be controlled with or without intervention
If urinalysis shows proteinuria, 24 hour urine collection is to be performed and the 24 hour urine protein is to be < 2 grams to be eligible
Patients who have proteinuria at baseline; patients who are unexpectedly discovered to have >= grade 2 proteinuria at baseline routine urinalysis should undergo a 24-hour urine collection, which must be an adequate collection and must demonstrate =< 1 g of protein/24 hour (hr) to allow participation in the study
In patients with metastatic pheochromocytoma, screening urinalysis required prior to study enrollment; if random collection urine specimen is positive for proteinuria, patients must have 24-hour urine protein determination; patients with metastatic pheochromocytoma are excluded if 24-hour urine protein is above the institutional upper limit of normal
If there is proteinuria present on dipstick, patients must have a 24 hour urine collection; patients are excluded if they have > 500 mg protein on 24 hour urine collection
Proteinuria at Screening. Subjects with a urine dipstick protein ?2+ at Screening should undergo a 24-hour urine collection and must demonstrate ?1g of protein in 24 hours to be eligible
Urine protein must be screened by urine analysis within 28 days prior to registration; patient must not have greater than +1 proteinuria on two consecutive dipsticks taken no less than 7 days apart; however, if the first urinalysis shows no protein, then a repeat urinalysis is not required
Renal involvement is defined as proteinuria (predominantly albumin) >0.5 g/day in a 24-hour urine collection. Note: Amyloid involvement of other organ systems is allowed, but not required.
Participants having > 1 + proteinuria on urine dipstick testing will undergo 24 hour urine collection for quantitative assessment of proteinuria. Participants with urine protein ? 1 gram/24 hours will be ineligible.
Measurable levels of myeloma paraprotein (M-protein) in serum (> 0.5 g/dL) or urine (> 0.2 g excreted in a 24-hour collection sample).
Proteinuria, as demonstrated by urine dipstick or > 1.0 g of protein in a 24-hour urine collection; all patients with >= 2+ protein on dipstick urinalysis at baseline must undergo a 24-hour urine collection for protein
Proteinuria at screening demonstrated by urine analysis (UA) > 1+ and 24 hour urine protein >= 1 gram/24 hours
Subjects having greater than 1+ proteinuria on urine dipstick testing will undergo a 24-hour urine collection for quantitative assessment of proteinuria. Subjects with a urine protein greater than or equal to 1 g/24 hours will be ineligible.
Persistent renal involvement from diagnosis with proteinuria (predominantly albumin) > 500mg/day in a 24-hour urine collection
Known proteinuria defined by >= 2+ protein by urinalysis (UA) or >= 1 gram protein by 24 hour urine collection; Note: Subjects that are >= 2+ or greater on dipstick but < 1 g protein on 24 hour urine ARE eligible to participate
Clinically significant proteinuria: \r\n* Subjects having > 1+ proteinuria on urinalysis will undergo 24-hour urine collection for quantitative assessment of proteinuria; subjects with urine protein >= 1 g/24-hour will be ineligible
Palliative radiation that does not include a target lesion is allowed. Subjects having a spot urine protein:creatinine ratio of > 1 will undergo 24-hour collection for quantitative assessment of proteinuria. If urine protein > 1 gram/24 hours, the subject will be ineligible
Subjects having greater than 1+ proteinuria on urine dipstick testing will undergo 24-hour urine collection for quantitative assessment of proteinuria. Subjects with urine protein greater than or equal to 1 g/24-hour will be ineligible.
Proteinuria: patients are allowed to have 0, trace, or 1+ protein by urine dipstick or urinalysis to enroll, if >= 2+ must check 24 hour (h) urine protein and must be < 1g to start study
Patients with proteinuria > 1+ on urine dipstick or urine protein creatinine (UPC) ratio >= 1 at screening; if > 1+ proteinuria is detected on surveillance, a 24-hour collection must be performed if eligibility is desired; patients with a 24-hour urine protein content of =< 500 mg are eligible
Patients with proteinuria on screening urinalysis confirmed to be > 1 g/24 hr by 24 hour urine collection
Less than or equal to 1+ proteinuria on two consecutive dipsticks taken no less than 1 week apart, OR < 1 gm protein on 24-hour urine collection or a urine protein: creatinine ratio of < 1
Measurable disease M component in serum (? 0.5 g/dL) and/or urine (? 0.2 g excreted in a 24 hour collection sample)
Proteinuria =< grade 1+ or 24-hour protein =< 1000 mg for patients with proteinuria above 1+ or urine protein to creatinine ratio < 1.0
Proteinuria at Screening. Subjects with a urine dipstick protein ? 2+ at Screening will undergo a 24-hour urine collection and must demonstrate ? 1g of protein in 24 hours to be eligible.
Less than or equal to 1+ proteinuria on two consecutive dipsticks taken no less than 1 week apart, or < 1 gm protein on 24-hour urine collection or a urine protein:creatinine ratio of < 1
If there is proteinuria present on dipstick, patients are excluded if they have > 500 mg protein on 24 hour urine collection
Participants having >1+ proteinuria on urine dipstick testing will undergo 24 hour urine collection for quantitative assessment of proteinuria. Participants with urine protein ?1 grams (g)/24 hours will be ineligible.
Proteinuria, as demonstrated by > 1.5 gram of protein in a 24-hour urine collection; all patients with >= 2+ protein on dipstick urinalysis at baseline must undergo 24-hour urine collection for protein
Proteinuria, as demonstrated by urine dipstick or > 1.0 g of protein in a 24-hour urine collection
If applicable, must be willing to collect a urine specimen and bring to the clinic; depending on specific planned uses, this may be a 24-hour collection, a 12-hour fasting collection, or a first morning collection
Participants must have a 24-hour calcium concentration that is =< 300 mg/24 hours as measured by 24-hour urine collection at baseline
- Proteinuria < 1 g/24 hours based upon 24 hour urine collection or spot urine protein/creatinine ratio
- Proteinuria < 1 g/24 hours based upon 24 hour urine collection or spot urine protein/creatinine ratio
Participants having >1+ proteinuria on urine dipstick testing will undergo 24-hour urine collection for quantitative assessment of proteinuria. Participants with urine protein ?1 g/24 h will be ineligible.
Proteinuria at screening as demonstrated by urinalysis with proteinuria ? 2+ (patients discovered to have ?2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate ? 1g of protein in 24 hours to be eligible).
A urine sample tested for proteinuria by the dipstick method must indicate 0 -1+ protein; if dipstick reading is >= 2+, a 24-hour urine specimen must demonstrate < 1.0 g of protein per 24 hours
Proteinuria as demonstrated by a urine protein:creatinine (UPC) ratio >= 1.0 at screening, or urine dipstick for proteinuria >= 2+ (patients discovered to have >= 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligible)
Proteinuria 3+ on dipstick analysis or > 500 mg/24 hours
Proteinuria: dipstick ?2+
Proteinuria =< 2+ by urinalysis or urine dipstick
Patients with proteinuria within 14 days of registration as demonstrated by either: urine protein creatinine (UPC) ratio >= 1.0 at screening OR urine dipstick for proteinuria 2+ (patients discovered to have 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24-hour urine collection, and must demonstrate =< 1 g of protein/24 hours to be eligible)
Proteinuria dipstick > 3+ or >= 2 gm/24 hours
Proteinuria =< +1 on dipstick or =< 1 gram/24 hours
Urine protein: creatinine ratio (UPC) of =< 1 or less than or equal to 2+ proteinuria on two consecutive dipsticks taken no less than 1 week apart; UPC is the preferred test; patients with >= 2+ proteinuria on dipstick must also have a 24 hour urine collection demonstrating =< 500 mg over 24 hours
Urine dipstick for proteinuria < 2+; patients discovered to have >= 2+ proteinuria on dipstick should undergo a 24-hour urine collection and demonstrate =< 1g of protein in 24 hours
Proteinuria as demonstrated by: \r\n* Urine protein: creatinine (UPC) ratio >= 1.0 at screening OR \r\n* Urine dipstick for proteinuria >= 2+ (patients discovered to have >= 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligible)
Urine for proteinuria should be < 2 +; patients discovered to have >= 2 + proteinuria on dipstick urinalysis at baseline should undergo a 24-hour urine collection and must demonstrate < 1 g of protein in 24 hours
Proteinuria as demonstrated by:\r\n* Urine protein: creatinine (UPC) ratio >= 1.0 at screening (patients discovered to have a UPC >= 1 should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligible) OR\r\n* Urine dipstick for proteinuria >= 2+ (patients discovered to have >= 2+ proteinuria on dipstick urinalysis may either undergo urine protein: creatinine (UPC) testing, and may participate if ratio < 1. 0 or should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligible)
Urine dipstick proteinuria >= 2+ or nephrotic range proteinuria on >= 2 gram in 24-hour urine
Urine for proteinuria should be < 2 +; patients discovered to have >= 2 + proteinuria on dipstick urinalysis at baseline should undergo a 24?hour urine collection and must demonstrate < 1 g of protein in 24 hours
Urine dipstick proteinuria < 2+ or urine protein/creatinine (UPC) ratio =< 1.0; Note: patients discovered to have >= 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24-hour urine collection and must demonstrate =< 1 g of protein in 24 hours
Proteinuria < 1+ on dipstick testing (if 2+ seen on first test, retest >= 24 hours later)
Within 28 days prior to administration of therapy: Proteinuria - urine protein:creatinine ratio (UPC) of =< 1 OR =< 2+ proteinuria on two consecutive urinalysis/dipstick tests taken no less than 1 week apart; patients with 2+ proteinuria on dipstick must also have a UPC of =< 0.5 on 2 consecutive samples
Absence of proteinuria at screening as demonstrated by one of the following:\r\n* Urine protein/creatinine (UPC) ratio < 1.0 at screening OR\r\n* Urine dipstick for proteinuria < 2+ (patients discovered to have >= 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligible)
Proteinuria =< +1 on dipstick or =< 1 gram/24 hours
Proteinuria at screening as demonstrated by either:\r\n* Urine protein:creatinine (UPC) ratio >= 1.0 at screening OR\r\n* Urine dipstick for proteinuria > 2+ (patients discovered to have > 2+ proteinuria on dipstick urinalysis at baseline must have a UPC ratio done that is < 1.0 to be eligible; if the UPC ratio is >= 1.0 then the patient should undergo a 24-hour urine collection which must demonstrate =< 1 g of protein in 24 hours for the patient to be eligible)
Patients with urine dipstick for proteinuria > 2+; patients with >= 2+ proteinuria on baseline dipstick analysis should undergo a 24-hour urine collection and must demonstrate =< 1 g of protein in the 24-hour urine; alternatively, proteinuria testing can be performed according to local standards
Patients with proteinuria (3+ on dipstick or 300 mg/dL on urine analysis or > 500 mg/dL/24 hours)
Urine dipstick for proteinuria < 2+ (patients discovered to have >= 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate =< 1g of protein in 24 hours to be eligible)
Patients must not have baseline proteinuria within 14 days prior to registration as demonstrated by either:\r\n* Urine protein: creatinine (UPC) ratio < 1.0 at screening, OR\r\n* Urine dipstick for proteinuria =< 2+; NOTE: patients discovered to have >= 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligible
Proteinuria < 3 + by urinalysis or urine dipstick
Urine dipstick for proteinuria < 2+; patients with < 2+ proteinuria on baseline dipstick analysis should undergo a 24-hour urine collection and must demonstrate =< 1 g of protein in the 24-hour urine; alternatively, proteinuria testing can be performed according to local standards
Urine dipstick proteinuria < 2+ or urine protein/creatinine (UPC) ratio =< 1.0 obtained =< 14 days prior to randomization\r\n* Note: patients discovered to have >= 2 + proteinuria on dipstick urinalysis at baseline should undergo a 24-hour urine collection and must demonstrate =< 1 g of protein in 24 hours
Proteinuria as defined as >= 2+ on urine dipstick; if dipstick urinalysis shows >= 2+ proteinuria, 24-hour urine for protein must be < 2 grams
Proteinuria at screening as demonstrated by urine dipstick >= 2+
Patient has proteinuria as demonstrated by urine protein:creatinine ratio ? 1.0 at screening or urine dipstick for proteinuria ? 2 (patients discovered to have ? 2 proteinuria on dipstick at baseline should undergo a 24-hour urine collection and must demonstrate < 2 g of protein in 24 hours to be eligible).
Urine for proteinuria >= 2+ (patients discovered to have >= 2+ proteinuria on urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligible)
Proteinuria > 1+ on urine dipstick testing or 30 mg/dL
Urine protein: urine protein:creatinine (UPC) ratio 1.0 OR urine dipstick for proteinuria: urine dipstick for proteinuria > 2+; patients discovered to have > 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligible
Proteinuria > 1+ on dipstick urinalysis; patients with > 1+ proteinuria on dipstick urinalysis will undergo 24-hour urine collection for quantitative assessment; NOTE: patients with > 1 g/24 hours will be ineligible