The subject received any investigational treatment within the past 30 days or prior immunotherapy or antibody therapy within the past 45 days.
Pamolidomide: 7 days
Patients must be at least 28 days past their last course of lymphoma or CLL treatment, at least 84 days past their last course of rituximab treatment. Patients with pre-existing severe or life threatening side effects/conditions from prior therapy or due to other diseases may not be enrolled
Concomitant medications:\r\n* Growth factors that support platelet or white cell number of function must not have been administered within the past 7 days\r\n* Patients with CNS tumors who have not been on a stable or decreasing dose of dexamethasone for the past 7 days\r\n* Patients who are currently receiving another investigational drug\r\n* Patients who are currently receiving other anti-cancer agents\r\n* Allergy or intolerance to agents on this protocol: vincristine, irinotecan, temozolomide, or metformin\r\n* Allergy to cephalosporins\r\n* Patients who have uncontrolled infection, positive blood cultures within the past 48 hours, or receiving treatment for Clostridium difficile infection
No increase in steroid dose within the past 7 days
Significant clinical change in health in the past 30 days
No chemotherapy or radiotherapy within the past 28 days
Systemic antineoplastic therapy in the past 14 days (excluding hydroxyurea)
Concomitant medications: the following drugs need to be stopped at the time of beginning therapy: patient cannot be on liver enzyme inducing anticonvulsants; patients must not have received growth factors to support the number or function of white cells or platelets within the past 7 days and pegfilgrastim within the past 14 days; patients must not be receiving any anti-thrombotic or anti-platelet agents; patient cannot be on drugs that cause significant prolonged QT (category I drug)
Tumor staging by standard imaging within the past 30 days (Step 1 subjects only)
Subject has received chemotherapy within the past 28 days
Erythropoietin or related hormones must not have been administered within the past 28 days
Prior investigational therapy within the past 28 days.
Prior cell therapy for relapse within the past 90 days
Received no other investigational therapy within the past 14 days
Enrollment in other studies for any disease in the past 30 days
No increase in steroid dose within the past 7 days
No patients receiving other investigational therapy for the past 30 days before dosing.
Past or current anti-cancer treatment except corticosteroids of less than 7 days duration in total
Any investigational therapy in the past 30 days
Prior radiopharmaceutical therapy (e.g. radium-223, strontium-89, samarium-153, etc) within the past 30 days
Has the subject received any investigational treatment within the past 30 days?
any investigational treatment within the past 30 days
Any change in psychotropic medications in past 30 days
Reports a fall in the past 30 days
Non-cigarette tobacco use in the past 30 days
Reports a fall in the past 30 days
Patient-reported cigarette use within the past 30 days
Psychostimulant use in the past 30 days prior to registration
Recent quitters (have not smoked in past 7 days)
Use of laxatives within the past 7 days
Use of antibiotics within the past 7 days
Smoke on >= 25 days of the past 30 days
PILOT III: Has experienced fatigue within the past seven days
Smoke on >= 25 days of the past 30 days
Patients who are receiving any other investigational agents (in the past 28 days) or herbal medication (within 1 day)
Patients who are receiving any other investigational agents (in the past 28 days) or herbal medications (within 1 day)
Other tobacco use within the past year for 7 consecutive days or 14 times
Report tobacco use within the past 7 days
Patients who are receiving any other investigational agents (in the past 28 days) or herbal medications (within 7 days)
Participants must not have had chemotherapy within the past 10 days
Current use of tobacco product other than cigarettes (e.g. e-cigarettes, smokeless tobacco)
Smoke at least 5 cigarettes/day or carbon monoxide (CO) reading of at least 8 ppm
Daily use of a second form of tobacco or nicotine (e.g. e-cigarettes, cigars, chewing tobacco, snuff)
Within the month immediately preceding the screening visit, use of any form of tobacco products other than cigarettes on 3 or more days within a week if the individual refuses to refrain from such tobacco use during the course of the study
Smoke an average of 5 or more cigarettes or little cigars per day (CPD) prior to telephone screen
Smoked at least 10 cigarettes/day for at least 1 year.
Concurrent use of tobacco products (other than cigarettes) or nicotine products.
Non-smokers, former smokers and/or smokers who have not smoked within 1 month before surgery, and who agree to not smoke or utilize e-cigarettes during the post-operative period
Willing not to smoke
Regular or sporadic use of nicotine cigarettes (> 1 cigarettes in the past 30 days)
Patients may not smoke or plan to smoke tobacco or marijuana during study therapy
PART I: Participants who smoke tobacco products will not be allowed to participate
PART II: Those who smoke tobacco products will not be allowed to participate
Smoked an average of less than 10 cigarettes per day during past month
Patient participants must also be a current smoker, defined as anyone who responds “every day” or “some days” to the question: “Do you smoke cigarettes every day, some days, or not at all?” (Behavioral Risk Factor Surveillance System [BRFSS])
Individuals who use e-cigarettes and who are not smoking cigarettes; dual users (those who use both e-cigarettes and cigarettes) will be included in the trial
Regular use of tobacco products other than cigarettes
Smoke >= 5 cigarettes (cig)/day during the last week
Individuals with a history of diabetes, hypertension, or have smoked cigarettes in the last 12 months.
Smokes a minimum of 3 cigarettes per day over the past year.
Smoke >= 10 cigarettes per day
Smoke >= 10 cigarettes per day for the last 6 months
Current smokers (smoked at least 100 lifetime cigarettes and currently smoke on some or every day) who would like help quitting
Exclusive use of tobacco products other than cigarettes, such as (but not limited to) cigars, chew, snuff, pipe or electronic (e)-cigarettes (cigs).
Smoking >= 5 tobacco cigarettes/week over the past year
Smoke at least 5 cigarettes daily for the past year
Ever used reduced nicotine cigarettes
Smoke ‘roll your own’ cigarettes exclusively
Used other tobacco products (including e-cigarettes) more than 9 days in the past month
Within the month immediately preceding the screening visit, use of any form of tobacco products other than cigarettes, little cigars or cigarillos on 3 or more days within a week if the individual refuses to refrain from such tobacco use during the course of the study
Have smoked cigarettes or used any other tobacco product in the past 30 days (i.e., pipe, cigar) and unwilling to stop use for the study period
Smokes >= 1 cigarettes per day (cpd)
Use of tobacco products other than cigarettes in past 30 days
Active use or recent use (=< to 1 month) of medication or e-cigarettes for nicotine dependence/smoking cessation, or use of e-cigarettes for more than 9 days in the prior month
Smoke at least weekly
Regular use of any form of tobacco other than cigarettes;
Within the month immediately preceding the screening visit, use of any form of tobacco products other than cigarettes, little cigars or cigarillos on 3 or more days within a week if the individual refuses to refrain from such tobacco use during the course of the study
Smoke one or more cigarettes on 25 out of the past 30 days
Current moderate-to-heavy smoker as determined by:\r\n* Has smoked greater than or equal to 10 cigarettes per day regularly for the past year (by history) (greater than or equal to 5 cigarettes per day for study 2) and,\r\n* Has an expired carbon monoxide (CO) at screening visit of 8 ppm or more (6 ppm or more for study 2)
Smoke at least 10 cigarettes daily for the past year
Smoke 5 or more cigarettes/day
Smoke cigarettes 25 of the past 30 days (not including days spent in the hospital)
Have smoked 100 cigarettes in their lifetime and currently smoke five or more cigarettes a day on average
STUDY I: Current dual users (of tobacco cigarettes and e-cigarettes) without interest in quitting smoking
STUDY II: Using e-cigarettes at least once per week over the past month
Currently smoke at least 5 cigarettes per day
Smoked at least 100 cigarettes in lifetime
Current use of >= 5 cigarettes/day
Smoke 3-20 cigarettes per day (cpd)
Use of tobacco products other than cigarettes in past 30 days
For traditional cigarettes (TC) smokers, daily TC smoking in the past 6 months, at least 10 cigarettes per day, with no EC exposure in the past 6 months
HEALTHY VOLUNTEER: Use of more than 5 cigarettes/day
Use of tobacco- or nicotine-containing products in excess of the equivalent of 5 cigarettes per day
Smoke at least five cigarettes daily for the past year
Willing to use electronic (e)-cigarettes
Use in the past 30 days of tobacco or nicotine products including e-cigarettes, other than regular cigarettes
Current use of tobacco products other than cigarettes (i.e. snuff, snuz, smokeless tobacco, cigars, pipes) or use of these products within 3 months of study registration
Regular use (e.g., greater than weekly) of tobacco products (including e-cigarettes) other than cigarettes
Use of > 25% of cigarettes in the form of roll-your-own cigarettes unless they are machine rolled and include a filter
Use of tobacco products other than cigarettes (i.e. snuff, snuz, smokeless tobacco, cigars, pipes)
Willingness to try novel cigarettes
Current, regular (i.e., monthly or more) use of nicotine replacement or other tobacco products, by self-report (e-cigarette users will be excluded if their average monthly use exceeds half of their average monthly use of conventional tobacco cigarettes)
Exclusive use of roll-your-own cigarettes (since the study uses manufactured cigarettes); and cannot be currently smoking more than 1/3 of roll your own cigarettes
Identification of cost being the primary reason why person does not smoke daily (so that the study outcome variable of smoking rate isn’t influenced by participant receiving research cigarettes)