A history of other malignancy =< 2 years previous; exceptions are malignancies with a negligible risk of metastasis or death (e.g., expected 5-year overall survival [OS] > 90%) that were treated with an expected curative outcome, such as squamous cell carcinoma of the skin, in-situ carcinoma of the cervix uteri, non-melanomatous skin cancer, carcinoma in situ of the breast, incidental histological finding of prostate cancer (tumor, node, metastasis [TNM] stage of T1a or T1b) or synchronous head and neck (H&N) primaries
History of prior invasive malignancy diagnosed within 3 years prior to study enrollment; exceptions are malignancies with a negligible risk of metastasis or death (e.g., expected 5-year OS > 90%) that were treated with an expected curative outcome, such as squamous cell carcinoma of the skin, in-situ carcinoma of the cervix uteri, non-melanomatous skin cancer, carcinoma in situ of the breast, or incidental histological finding of prostate cancer (TNM stage of T1a or T1b)
Prior history of malignancies, other than MDS or AML, unless the subject has been free of the disease for >= 1 year; however, subjects with the following history/concurrent conditions are allowed: basal or squamous cell carcinoma of the skin; carcinoma in situ of the cervix; carcinoma in situ of the breast; incidental histologic finding of prostate cancer (T1a or T1b using the tumor, node, metastasis [TNM] clinical staging system)
Curatively treated incidental prostate cancer (T1/T2a)
Subject has prior history of malignancies, other than MM, unless the subject has been free of the disease for >= 5 years with the exception of the following malignancies:\r\n* Basal cell carcinoma of the skin\r\n* Squamous cell carcinoma of the skin\r\n* Carcinoma in situ of the cervix\r\n* Carcinoma in situ of the breast\r\n* Incidental histologic finding of prostate cancer (T1a or T1b using the tumor, node, metastasis [TNM] clinical staging system) or prostate cancer that is curative
Subject has any other malignancy within 5 years prior to randomization. Exceptions include the following: squamous cell carcinoma of the skin, in-situ carcinoma of the cervix, uteri, non-melanomatous skin cancer, carcinoma in situ of the breast, or incidental histological finding of prostate cancer (TNM stage of T1a or T1b) — all treatments that should have been completed 6 months prior to signing ICF.
Subject has no other malignancy within 5 years, except non-melanoma skin cancer, cervical intraepithelial neoplasia, or in-situ cervical cancer or incidental histological finding of prostate cancer (TNM stage of T1a or T1b); all treatments of which should have been completed 6 months prior to signing ICF.
Incidental histologic finding of prostate cancer (T1a or T1b using the TNM [tumor, nodes, metastasis] clinical staging system) or prostate cancer that is curative
Prior history of cancer, other than MDS, unless the subject has been free of the disease for ? 3 years. (Basal or squamous cell carcinoma of the skin, carcinoma in situ of the cervix, carcinoma in situ of the breast, and incidental histologic finding of prostate cancer) (T1a or T1b using the tumor, nodes, metastasis [TNM] clinical staging system is allowed)
Incidental histologic finding of prostate cancer (T1a or T1b using the tumor, nodes, metastasis [Tumor, node, metastases (TNM)] clinical staging system).
Incidental histological finding of prostate cancer (TNM stage of T1a or T1b)
Incidental histologic finding of prostate cancer (TNM stage of T1a or T1b)
Incidental histologic finding of prostate cancer (TNM stage of T1a or T1b)
Incidental histologic finding of prostate cancer (TNM stage of T1a or T1b)
Incidental histologic finding of prostate cancer (TNM stage of T1a or T1b).
Subject has any other malignancy within 5 years prior to signing the ICF. Exceptions include the following: squamous cell carcinoma of the skin, in-situ carcinoma of the cervix, uteri, non-melanomatous skin cancer, carcinoma in situ of the breast, or incidental histological finding of prostate cancer (Tumor, node and metastasis (TNM) stage of T1a or T1b). All treatment should have been completed 6 months prior to signing ICF.
Incidental histological finding of prostate cancer (TNM stage of T1a or T1b)
Incidental histologic finding of prostate cancer (T1a or T1b using the tumor, nodes, metastasis [TNM] clinical staging system)
Incidental histologic finding of prostate cancer (T1a or T1b using the TNM [tumor, nodes, metastasis] clinical staging system) or prostate cancer that is curative.
Subject has prior history of malignancies, other than MM, unless the subject has been free of the disease or >= 5 years with the exception of the following malignancies\r\n* Basal cell carcinoma of the skin\r\n* Squamous cell carcinoma of the skin\r\n* Carcinoma in situ of the cervix\r\n* Carcinoma in situ of the breast\r\n* Incidental histologic finding of prostate cancer (T1a or T1b using the TNM clinical staging system) or prostate cancer that is curative
Patients must not have known history of tuberculosis
11. Known history of tuberculosis;
Has a known history of active tuberculosis (Bacillus tuberculosis).
Has a known history of active tuberculosis (TB) (Bacillus tuberculosis)
Known active TB (Bacillus tuberculosis); patients with a distant history of tuberculosis that was appropriately treated and have no evidence of active infection are eligible to participate; patients with a history of latent tuberculosis that was appropriately treated are also eligible to participate
Patient has a known history of active TB (Baccillus tuberculosis)
Has a known history of active tuberculosis (TB) (Bacillus tuberculosis)
Known history of active tuberculosis (TB)
Known history of active tuberculosis (TB, Bacillus tuberculosis)
Known history of active tuberculosis (TB; Bacillus tuberculosis)
Has a known history of active tuberculosis (TB) (bacillus tuberculosis)
Has a known history of active tuberculosis (TB) (Bacillus tuberculosis).
Has a known history of active tuberculosis (TB) (Bacillus tuberculosis)
Has a known history of active tuberculosis (TB) (Bacillus tuberculosis)
Has a known history of tuberculosis
Has a known history of active tuberculosis (TB) (Bacillus Tuberculosis)
Has a known history of active tuberculosis (Bacillus tuberculosis).
Has a known history of active TB (Mycobacterium tuberculosis).
Has a known history of active tuberculosis (TB) (Bacillus tuberculosis)
Has a known history of active tuberculosis (TB) (Bacillus tuberculosis)
Has a known history of active tuberculosis (Bacillus tuberculosis infection)
Has a known history of active tuberculosis (TB) (bacillus tuberculosis)
Has a known history of tuberculosis
Has a known history of active tuberculosis (TB) (Bacillus tuberculosis)
Known history of active tuberculosis (TB)
Has a known history of TB disease (Mycobacterium tuberculosis)
Known history of active tuberculosis (TB)
Has a known history of active tuberculosis (TB) (Bacillus tuberculosis)
Has a known history of active tuberculosis (TB; Bacillus tuberculosis)
Known history of active tuberculosis (TB; Bacillus tuberculosis)
Has a known history of active tuberculosis (TB) (Mycobacterium tuberculosis)
Has a known history of active tuberculosis (TB [Bacillus Tuberculosis])
Has a known history of active tuberculosis (TB) (bacillus tuberculosis)
Has a known history of active tuberculosis (TB) (Bacillus tuberculosis)
Known history of active tuberculosis (Bacillus tuberculosis [TB])
Has a known history of active tuberculosis (TB).
Patients must not have a known history of tuberculosis
Has a known history of active tuberculosis (TB) (Bacillus tuberculosis)
Has a known history of active tuberculosis (TB) (Bacillus tuberculosis)
Known history of tuberculosis
Known history of tuberculosis
Patients with any known active infection or known history of tuberculosis
Has a known history of active tuberculosis (TB; Mycobacterium tuberculosis) or human immunodeficiency virus (HIV) infection
Has a known history of active tuberculosis (TB, Bacillus Tuberculosis).
History of active tuberculosis (TB)
Subjects with known history of tuberculosis
Known history of active tuberculosis (TB)
Has a known history of active tuberculosis (Bacillus tuberculosis)
Has a known history of active tuberculosis (TB).
Has a known history of active tuberculosis (TB).
Has a known history of active tuberculosis (TB; Bacillus tuberculosis).
Active tuberculosis
Patient must not have active tuberculosis
Patient must not have active tuberculosis
Active tuberculosis
Active hepatitis B or C, or tuberculosis
Has a known history of active tuberculosis.
Has a known history of active tuberculosis
Has a known history of active tuberculosis
Patients with clinically active tuberculosis.
Active tuberculosis
Active tuberculosis
Known history of active tuberculosis
Known history of active tuberculosis.
Active tuberculosis
Active tuberculosis
Active tuberculosis
Subjects with a history of tuberculosis or a history of a chest X-ray suspicious for tuberculosis, unless confirmed to be purified protein derivative (PPD) negative or latent tuberculosis that has been previously treated.
Active tuberculosis
History of primary immunodeficiency or history of active tuberculosis; Note: latent tuberculosis will not be a basis for exclusion
Chronic infections (e.g., hepatitis B or C, tuberculosis)
Known active tuberculosis.
Known active tuberculosis or fungal infection
Significant acute or chronic infections including tuberculosis (history of exposure or history of positive tuberculosis test; plus, presence of clinical symptoms, physical or radiographic findings)
Active tuberculosis
Has a known history of active tuberculosis
GENERAL: Active tuberculosis.
Active tuberculosis infection
Hepatitis B or C, tuberculosis, or HIV.
History of active tuberculosis
Active tuberculosis
Active tuberculosis
Active tuberculosis.
Active tuberculosis
Active tuberculosis
Has known history of active tuberculosis
Known history of active tuberculosis
Active tuberculosis
History of tuberculosis treatment within 2 years of study entry
Active tuberculosis
Active tuberculosis
Known history of active tuberculosis
Active tuberculosis
Active or latent tuberculosis or hepatitis
Known history of active tuberculosis
Known history of active tuberculosis
Active tuberculosis
Active tuberculosis
Participants with suspected active or latent tuberculosis
Active tuberculosis
Patients with active tuberculosis are not eligible
Active tuberculosis
Active tuberculosis
Known active or latent tuberculosis
Negative for tuberculosis antigen (e.g. T-Spot test)
Subjects with a known history of tuberculosis or on anti-tuberculosis medication
Active tuberculosis
History of tuberculosis treated within the last five years or recent exposure to tuberculosis
Active tuberculosis or untreated, latent tuberculosis\r\n* If a patient has signs, symptoms, or a history suggestive of active tuberculosis, evaluation by an infectious disease physician will be required and active tuberculosis ruled-out prior to enrollment
History of tuberculosis or history of tuberculosis skin test purified protein derivative (PPD) positivity
Tuberculosis, history of tuberculosis or a known positive Quantiferon test for tuberculosis
Active tuberculosis
Patients with clinically active tuberculosis
Has a known history of active tuberculosis
Active tuberculosis.
Active tuberculosis (clinical evaluation that includes clinical history, physical examination and radiographic findings, and tuberculosis testing in line with local practice) infection.
Active tuberculosis
Active tuberculosis
Known history of active tuberculosis
Participants with known active tuberculosis not on active antitubercular agents
Active tuberculosis
History of pulmonary fibrosis/inflammation, including active tuberculosis
History of active or latent tuberculosis
Active hepatitis B or C virus infection or active tuberculosis
Active tuberculosis
Active tuberculosis
Active tuberculosis
Known active tuberculosis, or hepatitis B or C
Subject is know to have active tuberculosis, leishmaniasis, or listeriosis
Active tuberculosis
Known active tuberculosis
Active tuberculosis
History of known latent or active tuberculosis, signs of active or latent tuberculosis on chest X-ray, skin test showing an induration of > 10 mm or more or according to local recommendations
Has known history of active tuberculosis.
Known active tuberculosis.
Known history of active tuberculosis.
Patients with a history of active tuberculosis within the preceding two years
History of tuberculosis treatment within the preceding two years
Active tuberculosis
Active tuberculosis
History of active tuberculosis.
Patients with active tuberculosis
Has known history of active tuberculosis
Active tuberculosis
Known history of active tuberculosis
History of tuberculosis treatment within the preceding 2 years
History of tuberculosis within the preceding two years
History of tuberculosis
Patients with active tuberculosis
The subject is known to be positive for human immunodeficiency virus (HIV), hepatitis B or C, or active tuberculosis, or has a known history of tuberculosis
Active hepatitis B or C and/or tuberculosis
Subjects with active tuberculosis are ineligible. In settings where there is clinical or radiographic evidence of tuberculosis, active disease must be ruled out
Active tuberculosis
Active tuberculosis
History of serious co-morbidity or uncontrolled illness that would preclude study therapy, such as active tuberculosis or any other active infection.
Suspected or latent tuberculosis
Known active or latent tuberculosis infection
Active tuberculosis
History of tuberculosis
Incompletely treated active tuberculosis infection
Active tuberculosis
Patients with tuberculosis
History of tuberculosis treated within the last five years or recent exposure to tuberculosis
Current active tuberculosis or systemic fungal infection
Active tuberculosis, active hepatitis, or positive HIV status
Active tuberculosis
Active tuberculosis
Active tuberculosis
Active tuberculosis
Active infection including tuberculosis, HIV, hepatitis B anc C
Patients in Canada may not have a history or evidence of latent or active tuberculosis infection.
Active tuberculosis
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active (TB) (Bacillus tuberculosis)
COHORT 1: Has a known history of active TB (Bacillus tuberculosis)
Has active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis).
Patients who have a known history of active TB (bacillus tuberculosis) are not eligible
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Patient has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Has a known history of active TB (Bacillus Tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active Bacillus tuberculosis (TB)
Known history of active TB (bacillus tuberculosis)
Known history of active TB (bacillus tuberculosis)
Known history of active bacillus tuberculosis
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Participants must not have a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus Tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis).
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis).
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis).
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis).
Known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Known history of active TB (Bacillus tuberculosis)
Active bacillus tuberculosis (TB) or any other active or uncontrolled infection.
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Has a known history of active Bacillus tuberculosis (TB)
Has a known history of active TB (Bacillus tuberculosis)
Known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Known history of active TB (Bacillus tuberculosis)
Patient has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus Tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Known history of active bacillus tuberculosis (TB)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active bacillus tuberculosis (TB)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active bacillus tuberculosis (TB)
Has a known history of active TB (bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus Tuberculosis)
Known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
REGISTRATION TO TREATMENT (STEP 1): Patient must not have a known history of active TB (Bacillus Tuberculosis)
REGISTRATION TO TREATMENT (STEP 2): Patient must not have a known history of active TB (Bacillus Tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
History of active TB (bacillus tuberculosis)
History of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Has a known history of active Bacillus tuberculosis (TB)
Active TB (Bacillus tuberculosis) infection (as determined by Quantiferron Test)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
History of active TB (Bacillus tuberculosis)
Known history of active TB (Bacillus Tuberculosis)
Has a known history of active TB (Bacillus Tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus Tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Known history of active TB (Bacillus tuberculosis)
Patients with known human immunodeficiency virus (HIV) infection or active TB (Bacillus tuberculosis) are not eligible
Known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Known history of active TB (Bacillus Tuberculosis).
Has a known history of active TB (Bacillus tuberculosis)
Has a known history of active TB (bacillus tuberculosis)
Patients with active tuberculosis (TB) are excluded
Participants must be purified protein derivative (PPD) negative; alternatively, the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay can be used; an individual is considered positive for M. tuberculosis infection if the IFN-gamma response to tuberculosis (TB) antigens is above the test cut-off (after subtracting the background IFN-gamma response in the negative control); the result must be obtained within 12 weeks prior to enrollment; PPD positive (or Quantiferon assay positive) participants are permitted if prophylaxis has been completed prior to enrollment
Patients with active tuberculosis (TB) are excluded
Patients with known active tuberculosis (TB) are excluded
Positive test for latent TB at Screening (Quantiferon test)
Patients with tuberculosis (TB). Note: Patient with latent TB may be eligible based on the investigator's benefit-risk assessment.
Patients with TB. Note: Patient with latent TB may be eligible based on the investigator's benefit-risk assessment.
Patients with active tuberculosis (TB) are excluded
COHORT 2: Has a known history of active TB
Have previously received TB-403
Patients with active tuberculosis (TB) are excluded
Patients with active tuberculosis (TB) are excluded
No active tuberculosis (TB)
active tuberculosis (history of exposure or history of positive TB test with presence of clinical symptoms, physical or radiographic finding);
Known history of current or recent clinical diagnosis of tuberculosis (within 6 months prior to enrollment). A chest x-ray (XR) will be performed to screen for active tuberculosis (TB) for patients who have a history of treated TB. A chest XR will be performed in all patients to screen for active TB unless there has been a prior chest XR or computed tomography (CT) scan of chest within 1 month of entry
Confirmed current active tuberculosis (TB)
Known tuberculosis (TB) disease or latent TB infection
All potential patients must undergo a tuberculosis (TB) test prior to study entry (either purified protein derivative [PPD] or QuantiFERON-TB Gold, whichever is preferred and available at the Institution); patients with a history of TB (even if treated), or evidence of active or latent TB, are excluded; the diagnosis of active TB is defined per current guidelines; patients with a positive TB test (e.g. PPD or QuantiFERON-TB Gold) will be excluded; patients with history of Bacille-Calmette-Guerin (BCG) vaccination will be tested with QuantiFERON-TB Gold test in order to rule out exposure to TB
Presence of T4b disease, precluding organ preservation
Patients with T3b, or T4, or node positive disease will be excluded as they will be considered for adjuvant hormone therapy
Quantiferon tuberculosis (TB) gold must be performed for screening for mycobacterium tuberculosis infection; however, a tuberculin skin test may be placed if the Quantiferon TB gold test is indeterminate; patients must have a negative Quantiferon TB Gold (or tuberculin skin test) or evidence of appropriate treatment prior to study entry
Presence of active infection; history of exposure to TB (positive purified protein derivative [PPD] or Quantiferon TB gold) who have not been treated with a TB prophylaxis regimen for at least one month
Chest x-ray (if Quantiferon TB Gold is positive) demonstrating pleural scarring and/or calcified granuloma consistent with prior or current untreated TB
Willingness to complete tuberculosis evaluation and start prophylactic antituberculosis therapy as soon as is medically feasible if patients have a reactive tuberculin skin test and/or positive QuantiFERON-tuberculosis (TB) Gold test and have not completed an adequate course of prevented anti-tuberculosis therapy, following American Thoracic Society/Centers for Disease Control recommended guidelines
Clinical stages T1a-T2b
Active tuberculosis (history of exposure or history of positive TB test with presence of clinical symptoms, physical or radiographic finding);
Patients with active tuberculosis (TB)
Patients with active tuberculosis (TB) are excluded
Negative tuberculosis (TB) testing (Quantiferon – TB blood test or skin test) =< 7 days prior to registration
Positive test for latent tuberculosis (TB) at screening (Quantiferon test) or evidence of active TB
Active tuberculosis (TB):\r\n* Patients who are undergoing first month of therapy (RIPE or equivalent) for active TB\r\n* Patients with TB immune reconstitution syndrome (IRIS) requiring corticosteroids\r\n** Note: patients who are receiving therapy beyond month one of initial therapy with no evidence of TB IRIS requiring corticosteroid therapy, or those receiving treatment for latent tuberculosis (INH or alternative) may be eligible after discussion with the protocol P.I.
Clinical stage ? T2b
Participants with active tuberculosis (TB) will be excluded from the clinical trial
Clinical stages T1b – T3a
Stage T3b or greater disease
Patients with active tuberculosis (TB) are excluded
Patients must not have intra-operative evidence of T4b disease
Patients with active tuberculosis (TB) are excluded
Patients with T1 tumors on both cords (T1b)
Patients with T2b-T4 true larynx tumors
Has a known history of active TB.
Active Tuberculosis (TB)
Active tuberculosis (TB)
All patients will have a tuberculin (purified protein derivative [PPD]) skin test or interferon-gamma release assay (IGRA) done locally prior to the inclusion into the study. Patients with active tuberculosis (TB) will be excluded from the study.
Active TB
Active infection including tuberculosis (TB), hepatitis B, hepatitis C, or human immunodeficiency virus. Note: TB testing will be at the discretion of the treating physician and should be in line with local practice
Have received a diagnosis of localized disease confined to the prostate, with no regional lymph node or distant metastasis (stages T1, T1a, T1b, T2, T2a, T2b)
Received a diagnosis of localized disease confined to the prostate, with no regional lymph node or distant metastasis (stages T1, T1a, T1b, T2, T2a, T2b)
Participants are eligible if they received a diagnosis of localized disease confined to the prostate, with no regional lymph node or distant metastasis (stages T1, T1a, T1b, T2, T2a, T2b)
Received a diagnosis of localized disease confined to the prostate, with no regional lymph node or distant metastasis (stages T1, T1a, T1b, T2, T2a, T2b, T2c, T3, T3a, T3b, T3c)
Past history of tuberculosis (TB) or active infection with TB, human immunodeficiency virus (HIV), hepatitis B or hepatitis C.