Patients unable to lie flat comfortably for 2 hours Unable to lie flat during or tolerate PET/MRI, PET/CT or SBRT Patients must be able to lie flat for at least 60 minutes and fit on a PET-CT scanner Unable to lie flat, still or tolerate a PET scan Unable to lie flat, still or tolerate a PET scan Unable to lie flat, still or tolerate a PET scan SUB-STUDY I: Unable to lie flat during or tolerate PET/CT SUB-STUDY II: Unable to lie flat during or tolerate PET/CT SUB-STUDY III: Unable to lie flat during or tolerate PET/CT Unable to lie flat, still or tolerate a PET scan Unable to lie flat during or tolerate PET/MRI Unable to lie flat during or tolerate PET/CT Unable to lie flat, still or tolerate a PET/CT scan Unable to lie flat, still or tolerate a PET scan Patients must be willing to lie flat on their back in the PET/CT scanner for up to 2 hours to allow the imaging data to be obtained Patients must be able to lie flat for at least 60 minutes and fit on PET-CT scanner Ability to lie still for imaging Inability to lie flat and still for treatment delivery despite anti-anxiety and/or pain medications Have the ability to tolerate required SBRT-related procedures (eg: lie flat and hold position for treatment) as determined by the treating physician Able to lie within the PET scanner for at least 70 minutes while undergoing scanning Inability to lie still for the entire imaging time (due to cough, severe arthritis, etc.) Ability to tolerate radiation therapy (e.g. lie flat and hold position for treatment) All patients must be able to lie supine Inability to lie flat on a treatment table for > 60 minutes Subjects unable to receive study treatment planning secondary to body habitus or inability to lie flat on the stomach for at least 1 hour Subjects unable to receive study treatment planning secondary to body habitus or inability to lie flat on the stomach at length Ability to tolerate hypofractionated radiation therapy (e.g. lie flat and hold position) Patient must be able to lie still in full body cast for 45 minutes Inability to lie flat for > 1 hour Able to lie supine for approximately 60 minutes, the anticipated duration of each treatment session Contraindication to SBRT (this includes the inability to cooperate with any aspect of SBRT: such as the inability to lie still and breathe reproducibly) The subject is able to lie flat for up to 45 minutes for imaging studies Contraindication to SBRT or TEMLA; this includes the inability to cooperate with any aspect of SBRT such as the inability to lie still and breathe reproducibly Inability to lie still for the entire imaging time (due to cough, severe arthritis, etc.) Ability to tolerate stereotactic body radiation therapy (e.g. lie flat and hold position for treatment) Inability to lie on the TomoTherapy treatment table for one hour Ability to tolerate stereotactic body radiation therapy (e.g. lie flat and hold position for treatment) Inability to lie prone or supine for one hour Inability to lie supine in a full body cast for approximately 30 minutes, the anticipated duration of each treatment session Patients who cannot lie flat for 20 minutes Unable to lie on the back for an hour All patients must be able to lie supine Claustrophobia and/or inability to lie flat in magnetic resonance imaging (MRI) machine Patients must be able to lie still for a 1.5 hour PET scan Ability to lie still during DCE-MRI which may last for up to 60 minutes Inability to lie in the scanner for 30 minutes Patients not capable of undergoing a PET/MRI study due to weight, claustrophobia, or inability to lie still for the duration of the exam Ability to lie still for PET scanning Patients unable to lie prone for 30 minutes for imaging Patients who are unable to lie supine for a biopsy Inability to lie flat for 60-90 minutes Inability to lie still for the entire imaging time (approximately 30 minutes) Ability to lie still for PET scanning Inability to lie still for PET scanning Are in good health (other than having breast cancer) and can lie still in a prone position for 45 minutes inside MRI scanner Inability to lie still for the entire imaging time Inability to lie in the PET/CT scanner for the time required for scanning, up to 1 hour and 15 minutes (min) at a time and possibly with arms raised above the head for lung imaging Inability to lie still for the entire imaging time (e.g. cough, severe arthritis, etc.) Inability to lie flat for the duration of PET/CT and V/Q SPECT/CT (approximately 45 minutes for each study) Inability to lie still for the duration of the scanning procedure Patients who are unable to lie flat on the imaging systems long enough to permit imaging protocols to be performed Inability to lie in the scanner for 30 minutes Patients must be able to lie still for the tests; their girth and weight must be suitable to enter the gantry, which varies per tomograph Ability to lie motionless for up to 5 minutes Patient Volunteers: Ability to lie motionless for up to 5 minutes An inability to lie still for the tests and can lie still in a prone position for 30 minutes in an MRI scanner. Inability to tolerate MRI (e.g., inability to lie flat for > 1 hour) Patients who are not able to lie supine with arms raised, and cooperate with breathholding instructions Ability to lie still for PET scanning Inability to lie still for PET scanning Inability to lie still for the entire imaging time (e.g. cough, severe arthritis, etc.) Inability to lie comfortably on a bed inside the scanner for 60 minutes as assessed by physical examination and medical history (e.g. back pain, arthritis) Able to lie still for PET and MRI scanning Ability to lie still for PET scanning Inability to lie still for PET scanning Inability to lie still for the entire imaging time (e.g. cough, severe arthritis, etc.) Inability to lie still for the entire imaging time Inability to lie still for the entire imaging time (e.g. cough, severe arthritis, etc.); although at Mission Bay Hospital pediatric patients may be sedated per clinical protocol Inability to lie still for the entire imaging time (e.g. cough, severe arthritis, etc.) Ability to lie still for PET scanning Inability to lie still for PET scanning Inability to lie still for the imaging study Any medical condition which impairs the ability to lie flat and without movement for 15 minutes (e.g. cough, severe arthritis, etc.) Inability to lie still for the entire imaging time The subject is unable to lie still for ~75 minutes Inability to lie still for the entire imaging time Physical inability to undergo a scanning procedure (e.g., inability to lie flat for the required period of time – three sessions of roughly an hour each with ten minutes’ rest in between) Inability to lie still for imaging Weight =< 300 lbs (pounds) Patients with a body weight < 110 pounds (lbs) (50 kilograms [kg]) because of the amount and frequency with which blood will be drawn, and because of the skin biopsies required. Weight over 410 pounds. Subjects with baseline weight =< 40 kg (88 pounds [lbs]). Subjects weighing > 350 lbs. (weight limit for scanner table), or unable to fit within the imaging gantry Patient weight > 400 pounds (lbs) (table limit for PET scanner) Weight >= 120 pounds (lbs) Weight < 120 lbs at time of study enrollment Exclusion criteria (PET specific):\r\n* Pregnant or nursing women; extreme claustrophobia; weight near or greater than 350 pounds Patients who exceed the weight/size limits of the treatment table or CT scanner Weight >= 100 lbs Weight < 100 lbs Women who are morbidly obese (>300 lbs) Exclusion for fludeoxyglucose F 18 (FDG) scan is anyone exceeding the weight limit of the scanner (350 lb) Body weight less than 300 pounds (lbs.), as dictated by the weight limit for dual x-ray absorptiometry (DXA) scanner and Saris CycleOps Phantom 5 bicycle EXCLUSION - PATIENT: Body weight exceeds that allowable by the MRI table Subjects must have a stable weight (have not gained or lost 25 pounds in the last 6 months) Patient must NOT weigh more than the maximum weight limit for the table for the PET/CT scanner at the institution where the study is being performed Patient must NOT weigh more than the maximum weight limit for the PET/CT table for the scanner(s) to be used at each center Participants who exceed the weight limit for the operative surgical table, 350 lbs or who will not fit into the 60 cm diameter bore of the MRI scanner Participants who exceed the weight limit for the surgical table at Advanced Multimodality Image Guided Operating (AMIGO), 350 lbs or who will not fit into the 70 cm diameter bore of the MRI scanner at AMIGO or the 60 cm diameter bore of the pre-procedure imaging MRI scanner Subjects weighing > 136 kg (weight limit for scanner table) Weight greater than the 400-lb weight limit of the PET scanner Body weight >= 400 pounds or body habitus or disability that will not permit the imaging protocol to be performed Patient weight exceeds table limit for the PET/CT scanner (400 pounds) Subjects weighing > 350 pounds (lbs.) (weight limit for scanner table), or unable to fit within the imaging gantry Subjects weighing > 350 lbs; (weight limit for scanner table), or unable to fit within the imaging gantry Weight greater than that allowable by the MRI table Greater than 400 pounds in weight Participants with severe claustrophobia not relieved by oral anxiolytic medication or patients weighing > 136 kg (weight limit for scanner table) Weight exceeding capacity of imaging table Patients/subjects whose weight does not exceed 275 lbs Subjects weighing > 136 kg (weight limit for scanner) Weight < 350 lbs (patient bed max weight) Weight greater than the 400-pound (lb) weight limit of the PET scanner Individuals weighing more than 300 lb; (this is the weight limit of the scanner table) Weight more than 400 pounds (subjects who weigh more than 400 pounds will not be able to fit inside the imaging machines) Patient who weighs more than the weight limit for the PET table Weight > 350 lbs Weight over 350 lbs. Weight in excess of limitations of the scanner or girth that prohibits entry into the bore of the PET/CT scanner due to size Subjects weighing > 400 lbs (weight limit for scanner table), or unable to fit within the imaging gantry Subjects weighing > 350 lbs. (weight limit for scanner table), or unable to fit within the imaging gantry Subjects weighing > 136 kg (weight limit for scanner table) Subjects weighing >= 350 lbs or are unable to fit within the imaging gantry Weight exceeding capacity of imaging table Weight > 300 pounds (lbs) Body weight greater than 400 pounds (limit of Tanita scale)