History of acute pancreatitis within 1 year of study treatment or a history of chronic pancreatitis History of acute pancreatitis within 1 year of study entry or history of chronic pancreatitis Patients with a prior history of documented pancreatitis are not eligible History of chronic pancreatitis. Patients with laboratory evidence of pancreatitis are excluded. Patient has a history of pancreatitis History of recurrent pancreatitis History of acute pancreatitis within 1 year of study or history of chronic pancreatitis. History of acute pancreatitis within 1 year of study or history of chronic pancreatitis. Pancreatitis that is active or within the preceding 3 months which in the judgment of the endoscopist would make tumor injection likely to trigger severe recurrent pancreatitis History of pancreatitis History of acute pancreatitis within one year of study or history of chronic pancreatitis History of acute pancreatitis within 1 year of study or history of chronic pancreatitis History of pancreatitis History of acute pancreatitis within 1 year of screening or past medical history of pancreatitis Known history of pancreatitis History of diverticulitis or pancreatitis within 12 weeks of registration Current pancreatitis Subject with history of acute within one year of study entry or past medical history of chronic pancreatitis History of pancreatitis History of acute pancreatitis within 12 months prior to screening Patient has a history of acute pancreatitis within 1 year of screening or a past medical history of chronic pancreatitis History of pancreatitis or chronic pancreatitis. The patient has a history of pancreatitis. No clinical evidence of pancreatitis History of acute pancreatitis within 1 year prior to registration, chronic pancreatitis, alcohol abuse or uncontrolled hypertriglyceridemia (triglycerides > 450 mg/dL) History of ? Grade 2 pancreatitis PART B: History of acute pancreatitis within 1 year of study or history of chronic pancreatitis History of acute pancreatitis within 1 year prior to study entry or past medical history of chronic pancreatitis Individuals with a history of asparaginase-associated pancreatitis Patients with a prior history of documented pancreatitis History of pancreatitis of any grade History of pancreatitis History of acute or chronic pancreatitis or any risk factors that may increase the risk of pancreatitis. History of acute pancreatitis within 1 year of study entry Recent history of acute pancreatitis. Recent (3 months) history of acute pancreatitis. Patients with recent history of pancreatitis History of acute pancreatitis within 1 year of study or history of chronic pancreatitis Active or recent pancreatitis (within last 6 months) Patients with a history of pancreatitis History of acute pancreatitis within 1 year of study entry or past medical history of chronic pancreatitis Known history of acute or chronic pancreatitis Known history of acute or chronic pancreatitis Recurrent or chronic pancreatitis Known active or chronic pancreatitis Patients with acute or chronic liver, renal disease or pancreatitis Acute symptomatic pancreatitis within 6 months of study entry or a diagnosis of chronic pancreatitis at the time of randomization. Known acute or chronic pancreatitis Patients with acute or chronic liver, renal disease or pancreatitis Known history of acute or chronic pancreatitis Patients with acute or chronic liver, renal, lung disease or pancreatitis Patients with acute or chronic liver, renal disease or pancreatitis Acute or chronic pancreatitis Subject has known acute or chronic pancreatitis. Known symptomatic acute or chronic pancreatitis. Known history of acute or chronic pancreatitis Active or chronic pancreatitis Patients with acute or chronic liver, renal disease or pancreatitis Has a history of acute or chronic pancreatitis Patients with acute or chronic liver, renal disease or pancreatitis Diagnosis of acute or chronic pancreatitis Acute or chronic pancreatitis Acute or chronic renal disease or pancreatitis Presence of acute or chronic liver, renal disease, or pancreatitis Subjects with acute or chronic pancreatitis. Active or clinically symptomatic chronic pancreatitis or disease affecting pancreas Acute or chronic pancreatitis. Patients with acute or chronic liver, renal disease or pancreatitis History of acute or chronic pancreatitis Known acute or chronic pancreatitis 17. Pregnant or lactating females Arm B only (CC-122 in combination with ibrutinib): Acute or chronic pancreatitis Acute or chronic pancreatitis Patients with acute or chronic liver, renal disease, or pancreatitis Known gallbladder or bile duct disease, acute or chronic pancreatitis Known gallbladder or bile duct disease, symptomatic cholelithiasis, acute or chronic pancreatitis Indication for operative intervention being chronic pancreatitis At least two episodes of acute pancreatitis in the past 12 months; acute pancreatitis is defined any 2 of the following: (1) typical upper abdominal pain; (2) elevation in serum amylase or lipase >= 3 times upper limit of normal; (3) features of acute pancreatitis on cross-sectional imaging Known symptomatic acute or chronic pancreatitis. Acute or chronic pancreatitis Chronic or acute pancreatitis as evidenced by clinical or pathologic diagnosis