Substance abuse, or medical, psychological or social conditions that may interfere with the patient's participation in the study or the evaluation of the study results Substance abuse or medical, psychological, or social conditions that may interfere with the patient's participation in the study or evaluation of the study results. Substance abuse, medical, psychological or social conditions that may interfere with the subject’s participation in the study or evaluation of the study results Substance abuse or medical, psychological, or social conditions that, in the opinion of the Investigator, may interfere with the subject's participation in the clinical study or evaluation of the clinical study results. Substance abuse, medical, psychological or social conditions that may interfere with the patient’s participation in the study or evaluation of the study results Substance abuse, medical, psychological, or social conditions that may interfere with the subject's participation in the study. Substance abuse, medical, psychological or social conditions that may interfere with the subject’s participation in the study or evaluation of the study results Substance abuse, medical, psychological or social conditions that may interfere with the subject’s participation in the study or evaluation of the study results Has substance abuse or any other medical conditions that would increase the safety risk to the subject or interfere with participation of the subject or evaluation of the clinical study in the opinion of the Investigator Substance abuse, medical, psychological or social conditions that may interfere with the patient’s participation in the study or evaluation of the study results Medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results. Substance abuse, medical, psychological or social conditions that may interfere with the subject’s participation in the study or evaluation of the study results Substance abuse, medical, psychological or social conditions that may interfere with the subject’s participation in the study or evaluation of the study results Substance abuse, medical, psychological or social conditions that may interfere with the patient’s participation in the study or evaluation of the study results Substance abuse or medical, psychological, or social conditions that, in the opinion of the investigator, may interfere with the subject’s participation in the clinical study or evaluation of the clinical study results Substance abuse, medical, psychological or social conditions that may interfere with the subject's participation in the study or evaluation of the study results Medical, psychological, or social conditions that, in the opinion of the investigator, may increase the patient’s risk or interfere with the patient’s participation in the study or hinder evaluation of the study results Substance abuse or medical, psychological, or social conditions that, in the opinion of the Investigator, may interfere with the subject's participation in the clinical study or evaluation of the clinical study results. Substance abuse or any condition that might interfere with the subject's participation in the study or in the evaluation of the study results. Substance abuse, medical, psychological, or social conditions that may interfere with the patient’s participation in the study Substance abuse, medical, psychological or social conditions that may interfere with the patient’s participation in the study or evaluation of the study results Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results Substance abuse, psychological, or social conditions that may interfere with the patient's participation in the study or evaluation of the study results Substance abuse, medical, psychological or social conditions that may interfere with the subject’s participation in the study or evaluation of the study results Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the trial or evaluation of the trial result Substance abuse, medical, psychological or social conditions that may interfere with the subject’s participation in the study or evaluation of the study results Substance abuse, medical, psychological or social conditions that may interfere with the subject's participation in the study or evaluation of the study results. Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results including known non-compliance issues on study trials Substance abuse, medical, psychological or social conditions that may interfere with the subject's participation in the study or evaluation of the study results Substance abuse, medical, psychological or social conditions that may interfere with the subject’s participation in the study or evaluation of the study results Substance abuse, medical, psychological or social conditions that may interfere with the patient’s participation in the study or evaluation of the study results Substance abuse, medical, psychological or social conditions that may interfere with the subject’s participation in the study or evaluation of the study results Substance abuse, medical, psychological or social conditions that may interfere with the subject’s participation in the study or evaluation of the study results Substance abuse, medical, psychological or social conditions that may, in the opinion of the investigator, interfere with the patient’s participation in the study or evaluation of the study results Substance abuse, medical, psychological, or social conditions that may interfere with the patient’s participation in the study or evaluation of the study results Substance abuse, medical, psychological, or social conditions that may interfere with the patient’s participation in the study or evaluation of the study results Substance abuse, medical, psychological or social conditions that may interfere with the subject's participation in the study or evaluation of the study results Medical, psychological, or social conditions that, in the opinion of the investigator, may increase the patient’s risk or interfere with the patient’s participation in the study or hinder evaluation of the study results Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results Substance abuse, medical, psychological, or social conditions that may interfere with the subject's participation in the study or evaluation of the study results. Substance abuse, medical, psychological or social conditions that in the opinion of the investigator may interfere with the subject’s participation in the study or evaluation of the study results Substance abuse, medical, psychological or social conditions that in the opinion of the investigator may interfere with the subject’s participation in the study or evaluation of the study results Substance abuse, medical, psychological or social conditions that may, in the opinion of the investigator, interfere with the patient's participation in the study or evaluation of the study results Patients with substance abuse, medical, psychological or social conditions that may, in the opinion of the Investigator, interfere with the patient’s participation in the study or evaluation of the study results Substance abuse or medical, psychological, or social conditions that, in the opinion of the Investigator, may interfere with the subject's participation in the clinical study or evaluation of the clinical study results Substance abuse or medical, psychological, or social conditions that, in the opinion of the Investigator, may interfere with the subject's participation in the clinical study or evaluation of the clinical study results. Current or past substance abuse or any condition that might interfere with the subject's participation in the study or in the evaluation of the study results. Any medical, psychological, or social conditions, particularly if unstable, including substance abuse, that may, in the opinion of the Investigator, interfere with the subject's safety or participation in the study, protocol compliance, or evaluation of the study results Substance abuse, medical, psychological or social conditions that may interfere with the subject's participation in the study or evaluation of the study result. Substance abuse, medical, psychological or social conditions that may interfere with the subject’s participation in the study or evaluation of the study results Substance abuse, medical, psychological or social conditions that may interfere with the subject’s participation in the study or evaluation of the study results Medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results Substance abuse, medical, psychological, or social conditions that may interfere with the patient’s participation in the study Has substance abuse or medical, psychological, or social conditions that, in the opinion of the Investigator, may interfere with the subject's participation in the clinical study or evaluation of the clinical study results Substance abuse, medical, psychological, or social conditions that may interfere with the patient’s participation in the study Substance abuse or medical conditions such as clinically significant cardiac or pulmonary diseases or psychological conditions, that may, in the opinion of the Investigator, interfere with the subject's participation in the clinical study or evaluation of the clinical study results.