Metastatic disease to the central nervous system Metastatic disease to the central nervous system for which other therapeutic options, including radiotherapy, may be available Metastatic disease to the central nervous system for which other therapeutic options, including radiotherapy, may be available Metastatic disease to the central nervous system for which other therapeutic options, including radiotherapy, may be available. Metastatic disease to the central nervous system for which other therapeutic options, including radiotherapy, may be available. Metastatic disease to the central nervous system