No history of severe cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity; examples would include unstable angina, recent myocardial infarction, oxygen-dependent pulmonary disease, and osteoarthritis requiring imminent joint replacement; moderate arthritis that does not preclude physical activity is not a reason for ineligibility Ongoing restriction of physical activity with physician documentation Has chest pain brought on by physical activity Sedentary activity pattern (< 90 minutes per week of moderate-to-vigorous intensity sports activity) within the past year Individuals reporting < 3 days/week of mild or moderate activity Already using physical activity tracker or part of a physical activity program Are willing to abstain from heterosexual activity or practice physical barrier contraception prior to time of study entry to 6 months after the last day of treatment Having been treated with a total cumulative (lifetime) 131I therapeutic activity > 800 mCi (excluding 131I activity administered for diagnostic scans) Inability to participate in physical activity because of co-morbidity or disability (e.g., severe arthritic conditions) A history or presence of a comorbid disease for which diet modification and increased physical activity may be contraindicated or complicated Willingness to change diet, physical activity and weight Serum transaminases activity =< 3 x ULN Exercise/physical activity contraindicated Has given written consent prior to any trial-related activity is performed. (A trial-related activity is defined as any procedure that would not have been performed during the normal management of the patient). Be willing to abstain from heterosexual activity or practice physical barrier contraception from study entry to 6 months after the last day of treatment Endotoxin Activity Assay ? 0.60 EAA units Sedentary defined as participating in 2 or less days of dedicated physical activity per week Participates in 3 or more days of dedicated physical activity per week Approval from their treating physician to engage in moderate-intensity physical activity Patient-assessed ability to walk and engage in moderate physical activity Approval from their treating physician to engage in moderate-intensity physical activity Patient-assessed ability to walk and engage in moderate physical activity Already walking or engaging in other physical activity > 120 minutes per week as documented via subject self-report Unable to walk or engage in moderate-intensity physical activity Baseline weight-bearing physical activity less than 150 min·wk^-1 using the Paffenbarger physical activity questionnaire Any other condition that may impede testing of the study hypothesis, make it unsafe to engage in the physical activity program, or make the participant not available for end of study assessments (determined by the investigative team) Able to initiate a supervised exercise program (free from any cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity) Severe and/or uncontrolled comorbidity precluding safe participation in a physical activity program Report of at least 90 minutes of mindfulness activity (e.g., meditation, yoga) per week Medical clearance from an oncologist or primary care physician stating the participant is able to participate in an unsupervised, moderate-intensity physical activity program Report < 150 minutes of weekly moderate-to-vigorous physical activity (MVPA) on the Global Physical Activity Questionnaire (GPAQ) Physically able to engage in physical activity Medical condition contraindicating physical activity participation Participants must consume < 5 servings of fruits and vegetables per day and/or engages in < 150 weekly minutes of moderate to vigorous physical activity Sedentary 6 months before the baseline visit defined as those individuals not participating in a regular exercise program or not meeting the minimal physical activity recommendations from the General Surgeon which is accumulating 30 minutes or more of moderate physical activity on most days of the week Patient has severe disabilities limiting moderate physical activity, such as severe orthopedic conditions Approval from the treating clinician to engage in moderate-intensity physical activity Patient-assessed ability to walk and engage in moderate physical activity Are willing to attempt increase in physical activity level Survivors must not be performing >= 100 minute (min)/week of moderate-vigorous physical activity Conditions that would interfere with the safety of moderate-to-vigorous intensity physical activity; participants will be screened for safety using the validated Physical Activity Readiness Questionnaire (PAR-Q) Has chest pain brought on by physical activity Regular participation in moderate- or vigorous-intensity physical activity for >= 30 minutes at least 5 times a week and strength training for >= 2 days Primary physician consent to engage in physical activity unsupervised Presence of cardiovascular disease that would make physical activity risky at the discretion of the provider Moderate to highly active level of physical activity (e.g. currently participating in >= 60 minutes of moderate aerobic activity weekly) Phase 2: CRC survivors 6 months or greater post-treatment, who additionally do not follow guidelines for physical activity (PA) (150 minutes of moderate to strenuous exercise weekly), and average, at least 6 hours/day of sedentary behaviors The patient will also be provided with their own Philips Equivital® non-invasive, wearable activity monitoring device that will track activity and rest levels Participants must have a baseline activity level of < 150 minutes/wk of moderate to vigorous activity as calculated using the moderate to vigorous components of the Leisure Time Exercise Questionnaire (LTEQ) for physical activity (completed during screening) SUBJECT: Must be willing to register online and install the software to use an age-appropriate activity monitor and website, which will include sharing some personal identifiable information, to allow the participant to track their physical activity. SUBJECT: Currently engaging in > 3 hours of moderate to vigorous physical activity per week, as reported in the exercise screening questions completed at the pre-study screening evaluation. SUBJECT: Currently on or planning to begin active neoplastic therapy, as the side effects may significantly impair ability to participate in physical activity. Sedentary, as defined as < 60 minutes of recreation or work requiring modest PA/week based on the 7 day physical activity recall questionnaire Participants must also meet at least two of the following criteria related to lifestyle: 1) consume less than 3 servings of fruit and vegetable/day; 2) engage in less than 75 minutes moderate/vigorous activity per week, defined as anything that causes small increases in breathing or heart rate for a sustained amount of time (e.g., brisk walking, bicycling); and 3) engage in a mind-body practice less than 4 times a month Does not meet recommended guidelines for PA (< 100 min of moderate activity and < 75 min of vigorous activity per week) Approval from their treating physician to engage in moderate-intensity physical activity Patient-assessed ability to walk and engage in moderate physical activity Unable to walk or engage in moderate-intensity physical activity Currently physically active (> 90 minutes of moderate or vigorous physical activity per week) as determined by Leisure Score Index of Godin Leisure-Time Exercise Questionnaire [LSI]) Cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity; examples would include unstable angina, recent myocardial infarction, oxygen-dependent pulmonary disease, and osteoarthritis requiring imminent joint replacement; moderate arthritis that does not preclude physical activity is not a reason for ineligibility Have been cleared by their provider to engage low to moderate intensity physical activities Physician permission to engage in moderate-intensity physical activity Major contraindication to fish oil i.e. hypersensitivity to fish/oil or physical activity Patient reported regular participation in moderate- or vigorous-intensity physical activity for at >= 30 minutes at least 5 times a week and strength training for >= 2 days/week Must not have engaged in a regular (> 3x/week, physical activity program in the last 6 months) Physically capable to do the hula-based physical activity moderate and vigorous physical activity (MVPA) Are able to pass the Physical Activity Readiness Questionnaire or participant provides a letter from their physician or nurse practitioner clearing them for study participation No contradictions to exercise based on the Physical Activity Readiness Questionnaire (PAR-Q) Sedentary: < 90 minutes/week of moderate-intensity (not exhausting, light perspiration, e.g. fast walking, tennis, easy bicycling, easy swimming, popular and folk dancing) physical activity during the preceding 2 months, and < 30 minutes/month of any high-intensity activity (heart beats rapidly, sweating, e.g. running, aerobics classes, cross country skiing, vigorous swimming, vigorous bicycling) in the past 2 months CANCER PATIENT GROUP: Sedentary defined as < 60 minutes of recreation or work requiring modest physical activity (PA)/week CANCER PATIENT GROUP: Ability to perform the level of physical activity assessed by the Physical Activity Readiness Questionnaire (PAR-Q) NON-CANCER PATIENT GROUP: Ability to perform the level of physical activity assessed by the Physical Activity Readiness Questionnaire (PAR-Q) Less than 120 minutes/week of physical activity Approval from member of the treatment team to engage in moderate-intensity physical activity Patient-assessed ability to walk and engage in moderate physical activity Unable to walk or engage in moderate-intensity physical activity Report more than 120 minutes/week of physical activity Be inactive at baseline (< 150 minutes [min]/week of moderate physical activity) Patients who have any condition that contradicts moderate to vigorous exercise; are unable to walk unassisted; or are already meeting the physical activity guidelines of 150 min/week (wk) of moderate physical activity Phase 2 only: be currently sedentary (i.e., engage in < or = 60 minutes of purposeful moderate-intensity PA/week) Participants answering ‘Yes’ to one or more of the questions on the physical activity readiness questionnaire (PAR-Q) will need to obtain approval from a physician before they can participate in the intervention Patients must not be currently enrolled in an ongoing (participating for 6 months or longer) medically prescribed diet or physical activity regimen Patients who have participated in a marathon, triathlon, or other endurance-related physical activity within the previous 24 months Patients who have had surgery for weight loss\r\n* Note: women will not be excluded if their baseline lifestyle assessment indicates a healthy eating and moderate physical activity with the exception of the exclusion criteria above At the time of consent, patient or parent/guardian reports less than 420 minutes of moderate to vigorous physical activity over the last week < 30 minutes per day of self-reported moderate or vigorous physical activity (PA) Moderately sedentary lifestyle (less than 120 minutes/week moderate intensity activity) Answer “no” to all questions on the Physical Activity Readiness Questionnaire (PAR-Q) Willingness to change diet, physical activity, and weight Are currently enrolled in a physical activity and/or dietary clinical trial Meet all the following criteria related to lifestyle: a) consume less than 3 servings of vegetables (excluding any fried servings) and 1 serving of fruit (not including juice)/day; b) engage in less than 150 minutes moderate/vigorous intensity activity per week, defined as anything that causes small increases in breathing or heart rate for a sustained amount of time (e.g., brisk walking, bicycling); c) engage in a mind-body practice less once per week Able mentally and physically to participate in interventions in this study (Note: If there are one or more positive responses to the Physical Activity Readiness Questionnaire [PARQ], then a physician-release for exercise is required prior to obtaining consent) Not adherent to the standard for > five servings of fruits and vegetable and 150 minutes of physical activity Has physical limitations and cannot participate in physical activity Potential participants must be underactive (defined as participating in moderate or vigorous PA two days per week or less for 30 minutes or less each day) A medical condition that precludes moderate-vigorous physical activity as determined by health care provider Currently physically inactive; using the international physical activity questionnaire (IPAQ) short form physically inactive will be defined as scoring a 0 in both the moderate and vigorous activity questions, and engaging in walking that is =< 420 minutes per week Cleared to participate in moderate intensity exercise by:\r\n* Answering “no” to all questions of the physical activity readiness questionnaire (PAR-Q), with the exception of current use of prescription medications, which is permitted\r\n* Written clearance from primary care practitioner Cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity Subjects who are noted (upon initial online screening) to do 150 minutes or more of moderate level physical activity each week, get less than 8% of their calories from saturated fat, and eat more than 5 fruit and vegetable servings per day will not be eligible Any condition that, in the investigators’ judgment, would contraindicate diet modification, increased physical activity, use of metformin, or otherwise interfere with participation in the trial Medical, surgical or radiation oncologist agrees to subject participation in a diet and physical activity program. Cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity. Moderate arthritis that does not preclude physical activity is not a reason for ineligibility. Significant pulmonary, cardiovascular, orthopedic, or musculoskeletal problems that would, in their oncologist's judgment, limit their ability to participate in physical activity interested in increasing their physical activity, Contraindications to increasing physical activity including, but not limited to, A history or presence of a comorbid disease for which diet modification and increased physical activity may be contraindicated AIM 1: Not meeting national guidelines for aerobic physical activity (i.e., at least 150 minutes per week of moderate intensity aerobic physical activity) AIM 2: Not meeting national guidelines for aerobic physical activity (i.e., at least 150 minutes per week of moderate intensity aerobic physical activity) DISEASE CHARACTERISTICS:\n\n - Completely resected histologically confirmed adenocarcinoma of the colon\n\n - High-risk stage II disease, including one of the following:\n\n - T4 lesions\n\n - Less than 12 sampled lymph nodes\n\n - Poorly differentiated histology\n\n - Stage III disease, defined as having at least one pathologically confirmed\n positive lymph node or one pathologically confirmed positive tumour deposit.\n\n - Synchronous primary colon cancer allowed\n\n - Adjuvant chemotherapy treatment for colon cancer with a 5-fluorouracil- based regimen\n received with an intent to provide a complete course of treatment. While one current\n standard is 24 weeks of treatment, patients who are pre-planned to receive a shorter\n duration of chemotherapy, including as part of a research study will also be\n permitted. The actual treatment received may be less than 24 weeks; participants must\n have received a minimum of one treatment cycle.\n\n - Chemotherapy must have been completed (i.e. last dose received) a minimum of 60 days\n and a maximum of 180 days prior to registration.\n\n - Carcinoembryonic antigen (CEA) ? 5 ?g/L\n\n - Current physical activity levels do not meet the recommended guidelines (? 150 minutes\n of moderate-to-vigorous or ? 75 minutes of vigorous physical activity/week) as\n calculated using the Leisure Time Exercise Questionnaire (LTEQ)\n\n - Completion of chest x-ray or CT, and CT, MRI or ultrasound of abdomen within 60 days\n of registration; these imaging tests must not show evidence of metastatic or\n locally-recurrent colon cancer.\n\n - No rectal cancer\n\n PATIENT CHARACTERISTICS:\n\n - ECOG performance status 0-1\n\n - Absolute granulocyte count ? 1,000/mm³\n\n - Platelet count ? 100,000/mm³\n\n - Hemoglobin ? 100 g/L\n\n - Serum creatinine ? 1.5 times upper limit of normal (ULN)\n\n - Total bilirubin ? 1.5 times upper limit of normal (ULN)\n\n - Alkaline phosphatase < 2.5 times ULN\n\n - ALT < 2 times ULN\n\n - Not pregnant or planning to become pregnant within the next 3 years\n\n - Able (i.e., sufficiently fluent) and willing to effectively communicate with the\n physical activity consultant affiliated with the originating cancer center\n\n - Able (i.e., sufficiently fluent in English or French) and willing to complete the\n patient-reported outcome questionnaires, social determinants of exercise measurement,\n health economics, and physical activity questionnaires and logs\n\n - Able to complete the baseline exercise test\n\n - No significant comorbid conditions precluding participation in a physical activity\n program as determined by the investigator\n\n - Likely to participate in a physical activity program, as assessed by the investigator\n\n - No history of other malignancies, except adequately treated nonmelanoma skin cancer,\n curatively treated in situ cancer of the cervix, other solid tumors, Hodgkin lymphoma,\n or non-Hodgkin lymphoma curatively treated with no evidence of disease for > 5 years\n\n PRIOR CONCURRENT THERAPY:\n\n - See Disease Characteristics\n\n - No prior radiotherapy as a component of treatment for primary tumor\n\n - No concurrent treatment with additional chemotherapy or radiation\n\n - No concurrent treatment with any medications deemed by the investigator as likely to\n preclude participation in a physical activity program\n\n - No concurrent anticancer treatment including chemotherapy, biological, or targeted\n agents Sedentary baseline lifestyle, with an average of < 180 minutes/week of moderate-intensity aerobic activity EXERCISE INTERVENTION: No exercise intolerance Patients must be able to travel to one of the study-designated exercise facilities up to three days per week for four weeks during cycle 0, two days per week for cycles 1-8 (32 weeks) and once per week for cycles 9-11 (12 weeks). In addition, patients must be able to attend exercise testing visits as outlined in the Table 1.Required Initial Laboratory Values: Medical clearance to undergo a symptom-limited cardiopulmonary exercise test (CPET) and vigorous aerobic and resistance exercise training. o Appendix 8: Patients must answer 'No' to all questions. If patients answered 'Yes' to only Questions 8-11, they will be considered eligible upon physician clearance Men participating in vigorous aerobic exercise for more than 60 minutes per week or resistance exercise two or more days per week No exercise intolerance Physically able to exercise and physician consent to start an exercise program Patients who are planning on embarking on a new strenuous exercise regimen after first dose of study treatment; muscular activities, such as strenuous exercise, that can result in significant increases in plasma CK levels should be avoided while on MEK162 treatment Patients who are planning on embarking on a new strenuous exercise regimen after initiation of study treatment; note: muscular activities, such as strenuous exercise, that can result in significant increases in plasma CK levels should be avoided whilst on sonidegib study treatment Patients who are planning on embarking on a new strenuous exercise regimen after first dose of study treatment; nota bene (NB): muscular activities, such as strenuous exercise, that can result in significant increases in plasma CK levels should be avoided while on MEK162 treatment Men refusing to exercise a reliable form of contraception Patients who are planning on embarking on a new strenuous exercise regimen after first dose of study treatment; muscular activities, such as strenuous exercise, that can result in significant increases in plasma CK levels should be avoided while on MEK162 treatment No exercise intolerance Subjects planning on embarking on a new strenuous exercise regimen after first dose of study treatment that can result in significant increases in plasma CK levels Started or planning to start on strenuous exercise regimen after first dose of study treatment (i.e., muscular activities, such as strenuous exercise, that can result in significant increase in plasma CK levels should be avoided while on trametinib treatment) Planning to embark on a new strenuous exercise regimen after first dose of study treatment; NOTE: muscular activities, such as strenuous exercise, that can result in significant increases in plasma CK levels should be avoided while on binimetinib treatment Patients who are planning on embarking on a new strenuous exercise regimen after first dose of study treatment; NB: muscular activities, such as strenuous exercise, that can result in significant increases in plasma creatine kinase (CK) levels should be avoided while on MEK162 treatment Patients who are planning on embarking on a new strenuous exercise regimen after initiation of study treatment; NOTE: muscular activities, such as strenuous exercise, that can result in significant increases in plasma creatine kinase (CK) levels should be avoided whilst on LDE225 treatment Patients engaged in a resistance exercise training program. Patients who are planning on embarking on a new strenuous exercise regimen after initiation of study treatment; note that muscular activities, such as strenuous exercise, that can result in significant increases in plasma CK levels should be avoided while on LDE225 treatment Patients who are planning on embarking on a new strenuous exercise regimen after initiation of study treatment; muscular activities, such as strenuous exercise, that can result in significant increases in plasma CK levels should be avoided whilst on sonidegib treatment No exercise intolerance Joint disease limiting exercise capability Patients who are planning on embarking on a new strenuous exercise regimen after first dose of study treatment; muscular activities, such as strenuous exercise, that can result in significant increases in plasma CK levels should be avoided while on MEK162 treatment Patients who are planning on embarking on a new strenuous exercise regimen after first dose of study treatment; NB: muscular activities, such as strenuous exercise, that can result in significant increases in plasma CK levels should be avoided while on MEK162 treatment Patients who are planning on embarking on a new strenuous exercise regimen that can result in significant increases in plasma creatine kinase (CK) levels Patients who are planning on embarking on a new strenuous exercise regimen after first dose of study treatment; muscular activities, such as strenuous exercise, that can result in significant increases in plasma CK levels should be avoided while on MEK162 treatment PHASE II: Any medical contraindication to exercise according to a physician or physician’s designee PHASE II: Current physical activity level exceeding Centers for Disease Control and Prevention (CDC) guidelines for activity (60 min of moderate-vigorous exercise/day for 5+ days/week (wk) including 3+ days of vigorous intensity activities and muscle-strengthening exercises on 3+ days/wk and bone strengthening exercises on 3+ days/wk for children < 18 and 150 min of moderate vigorous exercise or 75 min of vigorous exercise/wk and 2+ days of muscle strengthening activities for adults >= 18); the CDC guidelines are used to determine exercise prescription in our intervention; individuals already exceeding the guidelines would be unlikely to benefit from participating Must be able to complete an acceptable muscular strength test (assessed using calculated one-repetition maximum [1-RM]) at baseline in the opinion of the fitness specialist, exercise physiologist, or trained designee administering the test Currently participate in less than 60 minutes of structured exercise/week Willing to travel to the exercise facility at University of Southern California (USC) Men must be obese (BMI > 25) and sedentary (< 60 minutes of structured exercise per week) Patients with a history of any musculoskeletal, cardiorespiratory or neurological diseases that preclude the participation in exercise must be evaluated by their physician to assess if they are suitable to proceed on study Are unable to travel to the exercise facility at USC Have an interest in being part of a study to evaluate yoga-derived exercises and eager to practice some kind of relaxation exercise daily for 3 months Able to understand the exercise program Able to maintain daily exercise logs Recent fracture or acute musculoskeletal injury that precludes the ability to weight bear fully on all 4 limbs in order to participate in an exercise intervention No obvious medical conditions or physical handicaps which would preclude an exercise regimen as determined by the radiation oncologist No history of any musculoskeletal, cardiorespiratory or neurological diseases that preclude the participation in exercise History of any musculoskeletal, cardiorespiratory or neurological diseases that preclude the participation in exercise Regularly engaged in moderate or vigorous-intensity exercise for at least 5 times a week Inability to exercise Able to exercise safely on a treadmill\r\n* Eligibility to exercise safely on a treadmill will be determined by physical examination during visit 1; if during visit 2 the subject is unable to complete or exercise safely on a treadmill, then the subject will be considered as withdrawn from the study The subject is not participating in regular physical exercise (more than 60 minutes of moderate intensity or 30 minutes of vigorous intensity exercise per week) or weight reduction dieting No plan to initiate a new program that could affect well-being during the study period (e.g., psychotherapy, new exercise regimen, meditation classes) Any patient who, in the opinion of the investigators, will be unable to comply with a supervised exercise regimen based on their developmental stage Currently not practicing yoga as a form of exercise and/or meditation Does not have neurological or musculoskeletal co-morbidity inhibiting exercise Has never been diagnosed by health care professionals to have absolute contraindications to exercise testing Currently practicing yoga as a form of exercise and/or meditation Has neurological or musculoskeletal co-morbidity inhibiting exercise Has been diagnosed by health care professionals to have absolute contraindications to exercise testing Physician consent to participate in vigorous aerobic or resistance exercise training Men participating in vigorous exercise for 75 minutes or more per week, and/or structured resistance exercise on three or more days per week are not eligible Currently (previous 6 months) engaged in structured exercise either aerobic or yoga based Physician (oncologist) clearance to participate in exercise at moderate to high intensity Participants have not received intravenous or oral chemotherapy on the same day and prior to scheduled exercise session Orthopedic or other restrictions or contraindications to high-intensity (cycling) exercise Participants have received intravenous or oral chemotherapy on the same day and prior to scheduled exercise session Physically able to undertake a diet and exercise program Low to moderate fitness level at baseline (to be assessed via interview with the exercise staff and through the CPET) Medical clearance based on medical chart review and normal electrocardiogram (ECG) (administered by a trained health professional) to undergo a symptom-limited cardiopulmonary exercise test and aerobic training intervention NON-RANDOMIZED OBSERVATIONAL COMPONENT ELIGIBILITY:\r\nMedical clearance based on medical chart review and normal electrocardiogram (ECG) (administered by a trained health professional) to undergo a symptom-limited cardiopulmonary exercise test and aerobic training intervention Identified as the active or maintenance stage of exercise behavior Performing less than 150 minutes of structured moderate-intensity or strenuous intensity exercise per week Able to complete an acceptable baseline cardiopulmonary exercise test (CPET), in the absence of high risk electrocardiogram (ECG) findings or other inappropriate response to exercise as determined by the investigator Performing less than 150 minutes of structured moderate-intensity or strenuous intensity exercise per week Exercise intolerance, defined by a VO2peak below that predicted for active age- and sex-matched individuals Able to complete an acceptable baseline cardiopulmonary exercise testing (CPET), in the absence of high-risk electrocardiograph (ECG) findings or other inappropriate response to exercise as determined by the investigator Young adults (YA) survivors who are currently meeting PA guidelines, or individuals who are determined by the investigators to not be physically able to participate in an independent exercise intervention such as hospitalized, wheel chair bound, unable to ambulate independently, on oxygen Patients participating in a structured exercise program in the past 6 months (mos) Recent (< 4 week) first diagnosis of a borderline-resectable pancreatic adenocarcinoma, assigned to receive neoadjuvant therapy and surgery at University of Colorado Cancer Center, physician clearance to participate in exercise program Co-morbid illness that would contraindicate maximal effort exercise testing or participation in regular exercise programming as determined by the treating physician or exercise physiologist Participation in more than 240 minutes of moderate-intensity exercise per week (as determined by Leisure Score Index of Godin-Leisure-Time Exercise Questionnaire [LSI] questionnaire) Medical contraindications to home-based exercise or low-fat, high fruit and vegetable diet Vigorous exercise > or = 60 min/week or moderate exercise > or = 150 min/week; if a combination of moderate and vigorous exercise are preformed, the minutes of moderate exercise/week plus 2 x minutes of vigorous exercise/week > or = 150 min/week Any patient unable to complete the exercise regimen or deemed a fall risk will be excluded Medically capable of performing moderate intensity exercise Have no contra-indication to moderate to vigorous aerobic exercise (e.g., infection, cardiopulmonary disease, musculoskeletal disease, psychiatric condition) Any uncontrolled illness or physical disability including, but not limited to, infection, cardiopulmonary disease, musculoskeletal or psychiatric condition that contradicts moderate to vigorous aerobic exercise; not able to walk unassisted Being active (self-reported >= 150 min/week [wk] moderate – strenuous-intensity exercise) Being inactive (self-reported =< 150 min/wk moderate – strenuous-intensity exercise) Able to understand the exercise intervention and able to maintain a daily exercise log Recent fracture or acute musculoskeletal injury that precludes the ability to weight bear fully on all 4 limbs in order to participate in an exercise intervention Any physical, psychological illness, and/or medical problems that restricted them from exercise Able to complete an acceptable baseline CPET, as determined by the absence of remarkable electrocardiogram (ECG) findings or other inappropriate response to exercise Medical clearance from attending oncologist or attending radiation oncologist to undergo a symptom-limited cardiopulmonary exercise test Sedentary, as per the leisure score index (LSI) of the Godin leisure-time exercise questionnaire (GLTEQ); participants who perform regular moderate or vigorous intensity exercise at least 5 days/week, for at least 30 minutes/session, are not eligible Able to complete an acceptable baseline cardiopulmonary exercise testing (CPET), as determined by the absence of remarkable electrocardiography (ECG) findings or other inappropriate response to exercise Be willing to participate in the exercise and in cognitive behavioral therapy (CBT) Are regularly engaged in moderate- or vigorous-intensity exercise for at least 150 minutes per week Less than 120 minutes of exercise per week (as determined by Leisure Score Index of Godin Leisure-Time Exercise Questionnaire [LSI]) Absolute contraindications to maximal exercise testing as recommended by the American Thoracic Society and exercise testing guidelines for cancer patients Medical or psychiatric conditions (beyond ovarian cancer, its treatment, and its symptoms) that would impair our ability to test study hypotheses (e.g. cardiac, pulmonary, or orthopedic history that would prohibit a program of walking for exercise; psychotic disorders, dementia, inability to give informed consent) Cardiovascular disease (unless the disease would not compromise the patient’s ability to participate in the exercise rehabilitation program) Acute or chronic respiratory disease that would compromise the patient’s ability to participate in the exercise rehabilitation program Acute or chronic bone, joint, or muscular abnormalities that would compromise the patient’s ability to participate in the exercise rehabilitation program Currently not involved in a regular (3 times per week) exercise program Have no contra-indication to moderate to vigorous aerobic exercise Current participation in an intervention targeting diet or exercise Women who become pregnant while enrolled will be discontinued from the study and will be instructed to exercise, which is the standard recommendation for cancer-related fatigue Currently underactive (< 60 minutes of moderate intensity exercise per week in the last month) (confirmed by self-report on the Health History Questionnaire) Have a known urethral stricture, colostomy, or inability to urinate requiring chronic urinary catheter; only men who are cleared by their physician to safely participate in a physical exercise program (including walking and lifting weights) will be eligible for this study Not previously engaged in regular exercise training (> 1-2 days/week [d/wk] for > 30 minutes/day [min/d]) in the past 6 months Acute or chronic bone/joint/muscular abnormalities compromising their ability to exercise Be currently enrolled in another intervention study or recently completed a study promoting healthy lifestyle behaviors (diet and/or exercise) Able to exercise on a treadmill or stationary cycle CONTROL (HEALTHY) GROUP: Able to exercise on a treadmill or stationary cycle Must have normal cardiopulmonary exercise test prior to exercise participation. Individuals who are unable to identify cycling classes in their community for exercise. By self-assessment, currently performing 60 minutes or less of purposeful exercise per week but able to walk at least 30 minutes on a level surface Willing and able to perform moderate intensity exercise at least 5 days per week for 6 months; this consists of a supervised exercise intervention at one of the 15 YMCAs affiliated with our program for 2 days per week; must be willing to perform unsupervised home exercise for the entire 6 months Willing to participate in a controlled dietary intervention with portion controlled meals and partial meal replacements plus 35 servings of fruits and vegetables/week for 6 months and track food intake and exercise Physical impairments (bad hip, knees, feet, peripheral neuropathy) that would prohibit performing moderate intensity exercise at least 5 days per week By self-assessment, currently performing 60 minutes or less of purposeful exercise per week but able to walk at least 30 minutes on a level surface Access to a smart phone capable of running MyFitnessPal and Garmin Connect apps and willing to have diet and exercise data from these apps viewed by study personnel Willing and able to perform moderate intensity exercise at least 5 days per week for 3 months; this consists of a supervised exercise intervention at one of the 15 YMCAs affiliated with our program for 2 days per week for 8 weeks, then 1 day per week for 4 weeks; must also be willing to perform unsupervised home exercise for the entire 3 months Willing to participate in a controlled dietary intervention with portion controlled meals and partial meal replacements plus 35 servings of fruits and vegetables/week for 3 months and track food intake and exercise Physical impairments (bad hip, knees, feet, peripheral neuropathy) that would prohibit performing moderate intensity exercise at least 5 days per week Underlying medical problems that contraindicate unsupervised exercise Performing less than 75 minutes of structured moderate-intensity or strenuous-intensity exercise per week Able to complete an acceptable baseline cardiopulmonary exercise testing (CPET) in the absence of high risk electrocardiography (ECG) findings or other inappropriate response to exercise as determined by the investigator PILOTS I AND II: Body mass index (BMI) of 25 or higher OR < 150 minutes of moderate to vigorous exercise per week OR < 5 servings of fruit and vegetables per day PILOTS I, II AND III: Capable of participating in moderate-vigorous unsupervised exercise PILOT III: Less than 150 minutes of exercise per week Inability to perform exercise with dominant leg Currently non-active (exercise two days or less per week) Willing and medically able to exercise safely and independently at a moderate intensity without direct supervision Have clearance from their primary care provider to participate in a diet and exercise weight control intervention Sedentary (have not participated in a regular exercise program in the past 12 months) Willing and able to travel to the exercise facility Have completed adjuvant chemotherapy and/or radiation within the past 3 years prior to study enrollment (when cytokine levels are predicted to be high) and able to initiate an exercise program Able to participate in exercise training Inability to exercise due to musculoskeletal issue, osteoarthritis or underlying cardiac disease Planning on changing diet or exercise behavior in the next 6 months willingness to attend weekly exercise intervention sessions at a SNAP Fitness location within 10 miles of the University of Minnesota campus, Are not free of unstable angina, arrhythmia, or severe systemic disease that would make moderate intensity exercise participation unsafe Ability to exercise on a treadmill or stationary cycle Inability to exercise on a treadmill or stationary cycle Those with contraindications for exercise tolerance test (ETT) testing, including unstable angina or inability to exercise on a treadmill or stationary cycle Recent fracture or acute musculoskeletal injury that precludes the ability to fully bear weight on all 4 limbs in order to participate in an exercise intervention (PCS study) Attending surgeon clearance to undergo a supervised exercise training program Contraindication to exercise training, such as skeletal metastases, symptomatic coronary artery disease, severe anemia, or any condition limiting their ability to participate in an exercise training program