Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of first dose of treatment. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device =< 28 days prior to registration COHORT 1: Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment\r\n* NOTE: Subjects who were treated on a clinical study of allogeneic stem cell transplant (alloHSCT) will be eligible if they are at least 3 months after allogeneic HCT and are at least 3 weeks (>21 days) off of all immune suppression and have no evidence of active GVHD (physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency is allowed). Subjects with prior alloHSCT will not be eligible for enrollment during the safety run in phase COHORT 2: Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment for pre-existent myeloid disorder such as MDS or MPN Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of study drug. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of study medication Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study therapy Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of study treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of study registration Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks or 5 half-lives of the first dose of treatment, whichever is shorter Has participated in a study of an investigational agent and has received study therapy or has used an investigational device within 28 days of administration of MK-1454. Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of study medication Currently participating and receiving study therapy in, or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the date of allocation/randomization Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment; has a diagnosis of immunodeficiency or is receiving systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of trial treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks prior to administration of pembrolizumab. Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of study drug. Is currently participating and receiving study therapy or has participated and received study therapy in a study of an investigational agent, or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy within 4 weeks of first dose of treatment or used an investigational device within 4 weeks of the first dose of treatment. EXCLUSION - PARTICIPANT: Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigation device within 4 weeks of first dose of treatment. \r\n* Individuals in the follow-up phase of a prior investigational study may participate as long as it has been 4 weeks since last dose of the previous investigational agent of device. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 2 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Participants must not be currently receiving study therapy or have participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 2 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving pembrolizumab or has participated in a study of an investigational agent and received pembrolizumab or used an investigational device within 4 weeks of the first dose of study treatment. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 28 days of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment. Is currently participating in and receiving study therapy, or has participated in a study of an investigational agent and received study therapy, or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy of an investigational agent and received study therapy within 2 weeks of the first dose of treatment; this 2 week washout period would not apply to investigational food ingredients Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of on-study date Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy, or herbal/complementary oral or IV medicine within 2 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks prior to the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigation device within 28 calendar days of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device =< 28 days of registration Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first planned dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 2 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of study treatment. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 3 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy with another investigational device or study drug or has participated in a study of an investigational agent and received study therapy or used an investigational device within 3 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of study drug Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy within 4 weeks of the first dose of treatment Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device =< 4 weeks of the first dose of study drug Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 3 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of day 1 Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy, herbal/complementary oral or IV medicine, or used an investigation device within 4 weeks of the first dose of treatment; subjects must also have recovered from associated therapy (i.e., to grade =< 1 or baseline) and from adverse events due to any prior therapy Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy, herbal/complementary oral or IV medicine, or used an investigation device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy, herbal/complementary oral or IV medicine, or used an investigation device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the initiation of SBRT Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational new drug and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving a study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the study drug administration Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment; an exception will be made for patients who have received CTL019 on experimental protocol; these patients will be eligible to enroll once progression of disease or failure to respond is documented by clinical or radiologic assessment Is currently participating in and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment. Currently receiving or has had treatment with an investigational agent or used an investigational device within 4 weeks of study day 1 Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study drug or using an investigation device within 4 weeks of the first dose of treatment Currently participating or has participated in a study of an investigational agent and received study therapy or received investigational device within 4 weeks prior to the first dose of study treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 2 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment REGISTRATION TO TREATMENT (STEP 1): Patient may not be currently participating and receiving study therapy or have participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy, or has participated in a study of an investigational agent and received study therapy, or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 3 weeks of the first dose of treatment Currently participating and receiving study therapy, or have participated in a study of an investigational agent and received study therapy, or used an investigational device =< 4 weeks of registration Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm OR participated in a study of an investigational agent, received study therapy or used an investigational device =< 4 weeks prior to registration Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Currently participating and receiving treatment in another study, or participated in a study of an investigational agent and received treatment, or used an investigational device within 4 weeks of randomization Is currently participating, or has participated in a study of an investigational agent and received study drug, herbal/complementary oral or IV medicine, or used an investigational device within 4 weeks of the first dose of study drug. Participants must also have recovered from associated therapy (i.e., to Grade ?1 or baseline) and from adverse events (AEs) due to any prior therapy. Is currently participating in and receiving study therapy or has participated in a study of an investigational agent and received study drug or used an investigational device within 4 weeks of treatment allocation Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of study drug. Currently participating in and receiving study therapy or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study medication Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigation device within 4 weeks of the first dose of study drug. Is currently participating in and receiving study therapy or has participated in a study of an investigational agent or used an investigational device within 4 weeks of the first dose of study therapy Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks prior to administration of pembrolizumab. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment. Currently receiving or has received an investigational treatment as part of a study of an investigational agent or has used an investigational device within 4 weeks before randomization. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy, herbal/complementary oral or IV medicine, or used an investigational device within 4 weeks of the first dose of study drug. Participant must also have recovered from associated therapy (i.e., to Grade ?1 or baseline) and from adverse events due to any prior therapy Is currently participating in or has participated in a clinical study and received an investigational agent or used an investigational device within 4 weeks prior to the first dose of study treatment Patients currently participating and receiving study therapy or who have participated in a study of an investigational agent and received study therapy or used and investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of study medication Participant is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks prior to administration of pembrolizumab and CC-486 Currently participating in another study and receiving trial treatment, participated in a study of an investigational agent and received trial treatment within 4 weeks of the first dose of medication in this study, or used an investigational device within 4 weeks of the first dose of medication in this study. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study drug or using an investigation device within 4 weeks of the first dose of treatment Currently participating and receiving study therapy, or participated in a study of an investigational agent and received study therapy or used an investigation device within 4 weeks of the first dose of medication Currently participating and receiving study therapy, or participated in a study of an investigational agent and received study therapy or used an investigation device within 4 weeks of the first dose of study medication Currently participating and receiving study therapy, or participated in a study of an investigational agent and received study therapy, or used an investigational device within 4 weeks of the first dose of study medication Currently participating or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks prior to the first dose of study treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Currently participating and receiving another study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy in a study of an investigational agent or has participated and received study therapy in a study of an investigational agent or has used an investigational device within 28 days of administration of MK-3475 Concurrent enrollment in another therapeutic investigational clinical study or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of study drug Is currently participating and receiving study treatment or has participated in a study of an investigational agent and received study treatment or used an investigational device within 4 weeks of the first dose of treatment for another health-related problem Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Has participated in a study of an investigational agent and received study therapy or used an investigational device within 28 days of study start Patient is premenopausal (medical ovarian suppression is allowed); is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 2 weeks of the first dose of treatment Is currently participating and receiving study therapy for his/her advanced melanoma or has participated in a study of an investigational agent and received study therapy in the advanced melanoma setting Currently participating and receiving study therapy (except lenvatinib for patients in cohort 2) or has participated in a study of an investigational agent and received study therapy within 4 weeks prior to registration Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigation device within 4 weeks prior to enrollment . Is currently participating in or has participated in a study of an investigational agent and is currently receiving study therapy or has participated in a study of an investigational agent and has received study therapy or used an investigational device within 4 weeks of the first dose of study drug. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment Patients who are currently participating in or have participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or used an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment. Currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of study drug Is currently participating in or has participated in a trial of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of trial treatment. Is currently participating in or has participated in a trial of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study therapy Participated in another investigational study (drug or device) within 4 weeks of first dose Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Currently participating in or has participated in a study of an investigational agent or using an investigational device =< 28 days prior to registration Currently receiving any other investigational agents or has participated in a study of an investigational agent or using an investigational device within 3 weeks of the first dose of MK-3475 Currently receiving any other investigational agents or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of MK-3475 Is currently participating in or has participated in a study of an investigational agent or an investigational device within 4 weeks of the first dose of treatment. Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment\r\n* Note: Participants who have entered the follow-up phase of an investigational study may participate as long as it has been 4 weeks after the last dose of the previous investigational agent Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment Is currently participating in or has participated in a study of an investigational agent or used an investigational device within 4 weeks prior to the first dose of study treatment. Note: Subjects who have entered the follow-up phase of an investigational trial may participate as long as it has been 4 weeks after the last dose of the previous investigational agent. Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment. Patients who have participated in a study with an investigational agent or device within 2 weeks of enrollment Patients who have participated in a study with an investigational agent or device within 2 weeks of initiation of treatment Currently participating in a study of an investigational agent Subjects participating in or who have participated in a study of an investigational agent or is using an investigational device within 4 weeks of the first dose of study treatment or have received any anti-cancer therapy, platinum-based chemotherapy, targeted, biological (including humanized antibodies), investigational, immunotherapy, or hormonal agent, within 4 weeks of the first dose of study treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Patient is currently participating or has participated in a study of an investigational agent or using an investigational device within 28 days of the first dose of study drug Currently participating or has participated in a study of an investigational cancer therapy agent or using an investigational device within 28 days prior to study registration Is currently participating in a study of an investigational anti-cancer agent. Is currently participating or has participated in a study of an investigational agent or using an investigational device within 30 days of the first dose of trial treatment; the 30 day window should be applied to the last dose of an antineoplastic investigational agent or last use of an investigational device with antineoplastic intent Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment or 5 half-lives, whichever is shorter Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of pembrolizumab Patients may not be receiving any other investigational agents and may not have participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks prior to the first dose of trial treatment Is currently participating or has participated in a study of an investigational agent or using an investigational device Currently receiving any other investigational agents, has participated in a study of an investigational agent, or use of an investigational device within 4 weeks of the first dose of pembrolizumab Currently receiving any other investigational agents or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of MK-3475 Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Patients currently participating or has participated in a study with an investigational compound or device within 4 weeks of initial dosing with study drugs Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent (except glutamine) or using an investigational device within 4 weeks of the first dose of treatment or 5 half lives, whichever is shorter Subject is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of study treatment Is currently participating in a study of an investigational anti-cancer agent Is currently participating in or has participated in a study of an investigational agent (except glutamine) or using an investigational device within 2 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Subject is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Currently participating or has participated in a study of an investigational agent or using an investigational device within 28 days of administration of MK-4166 Patient is currently participating or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of study drug Patients may not be receiving any other investigational agents and may not have participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Patient is currently participating or has participated in a study of an investigational agent or using an investigational device within 28 days of the first dose of study drug Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 14 days of the first dose of treatment; Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks prior to the first dose of study drug. Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment. Currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment. Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating or has participated in any other any other investigational or therapeutic trial before or after chemoradiation. Patient is currently participating or has participated in a study of an investigational agent or using an investigational device within 30 days of the firs dose of study drug (a patient in the survival follow up phase of an investigational agent where no further treatment is expected is eligible) Patients who have participated in a study with an investigational agent or device within 2 weeks of initiation of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 2 weeks of the first protocol treatment Patients who are currently participating in or have participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment; Note: participants who have entered the follow-up phase of an investigational study may participate as long as it has been 4 weeks after the last dose of the previous investigational agent Is currently participating in or has participated in any study of an investigational agent or using an investigational device within 4 weeks of transplant admission Patient has participated in an investigational research study using an investigational agent within the last 30 days prior to screening Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks prior to allocation, has had major surgery within 4 weeks or radiation therapy within 2 weeks prior to allocation, or who has not recovered (i.e., ? Grade 1 or to Baseline) from AEs due to prior treatment. Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to randomization. Currently participating or has participated in a study (treatment period only) of an investigational agent or used an investigational device within 28 days of enrollment Currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks prior to the first dose of study drug Subject is currently participating or has participated in a study of an investigational agent or using an investigational device within 30 days of the first dose of study treatment Currently participating or has participated in a study of an investigational agent or using an investigational device within 4 weeks of administration of pembrolizumab Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Currently participating or has participated in a study of an investigational agent or using an investigational device within 30 days of first dose of study drug Currently participating or has participated in a study using an investigational antineoplastic agent or device within 30 days of first dose Subject is currently participating or has participated in another clinical trial within the past 30 days and is receiving/has received an investigational drug, device, or biologic agent; and Patient is currently participating or has participated in a study of an investigational agent or using an investigational device within 4 weeks of administration of study therapy Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or is or has been using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 2 weeks (4 weeks for monoclonal antibodies) of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of registration. Subjects are not permitted to participate in another investigational drug study while being treated on this protocol. Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device 4 weeks since last dose of agent administration Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 2 weeks of the radiation therapy Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks prior to the first dose of trial medication Currently receiving treatment in a study of an investigational agent or using an investigational device <= 4 weeks prior to the first dose of trial medication Currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks prior to randomization Patient is currently participating or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of study drug Patient is currently participating or has participated in a study with an investigational compound or device within 30 days of Study Day 1 Subjects participating in or who have participated in a study of an investigational agent or is using an investigational device within 4 weeks of the first dose of study treatment or have received any anti-cancer therapy, chemotherapy, targeted, biological (including humanized antibodies), investigational, immunotherapy, or hormonal agent, within 4 weeks of the first dose of study treatment Is currently participating in or has participated in an interventional clinical study with an investigational compound or device within 4 weeks of the first dose of treatment in this current study. Patient is currently participating or has participated in a study with an investigational compound or device within 30 days of initial dosing with study drug(s) Patient is currently participating or has participated in a study with an investigational compound or device within 30 days of initial dosing with study drug(s) Is currently participating in or has participated in a study of an investigational agent or using an investigational device. Patients who are currently participating in or have participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Currently receiving any other investigational agents or has participated in a study of an investigational agent or using an investigational device within 4 weeks prior to day 1 Is currently participating or has participated in a study with an investigational agent or using an investigational device within 4 weeks of the first dose of study therapy Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a trial of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment. Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment Is currently participating in a clinical study and receiving an investigational agent and/or using an investigational device, or has participated in a clinical study and received an investigational agent and/or used an investigational device within 4 weeks prior to randomization. Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of the first dose of treatment Participants may not be receiving any other study agents Participants may not be receiving any other study agents Participants may not be receiving any other investigational agents; patients may not be receiving any other treatment for their rectal cancer during study participation and within 30 days prior to study treatment Participants may not be receiving any other study agents concurrently with the study drugs Participants may not be receiving any other research study agents Participants may not be receiving any other study agents for at least 7 days prior to enrollment Participants may not be receiving any other study agents Participants may not be receiving any other study agents Participants who are currently receiving other anticancer agents. Participants may not be receiving any other study agents Participants may not be receiving any other study agents, and may not have received any other investigational agents within 6 months prior to study entry Patients receiving any other study agents Participants who are receiving any other study or off protocol anti-cancer agents May not be receiving any other study agents Participants may not be receiving any other study agents PHASE I: Participants may not be receiving any other study agents within 2 weeks of initiating treatment Participants may not be receiving any other study agents concurrently with the study drugs Participants receiving any other study agents Participants may not be currently receiving any other experimental agents Participants may not be receiving any other study agents Participants may not be receiving any other study agents Participants may not be receiving any other study agents. Participants may not be receiving any other study agents Participants may not be receiving any other study agents Participants may not be receiving any other study agents Participants may not be receiving any other study agents Participants may not be receiving any other study agents Participants may not be receiving any other study agent Participants may not be receiving any other study agents Participants may not be receiving any other study agents during the study or within 4 weeks of the start of the trial EXPANSION COHORT ONLY: Participants may not be receiving any other study agents during the study or within 4 weeks of the start of the study Participants may not be receiving any other study agents Participants may not be receiving any other study agents at the time of first treatment Participants may not be receiving any other study agents Participants may not be receiving any other study agents or other types of cancer therapy while on this protocol except for disease progression Participants may not be receiving any other study agents within 21 days prior to entry on the study Participants may not be receiving any other study agents Patients receiving any other study agents Participants who are receiving any other investigational agents that might interact with study medication or influence the measurement of study outcomes Patients receiving any other study agents Receiving any other investigational agent that would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Currently receiving or have received any other investigational agent considered as a treatment for the primary neoplasm =< 21 days prior to registration Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm =< 21 days prior to registration Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm or used an investigational device =< 4 weeks from registration Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any investigational agent, that would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Currently receiving or have received any other investigational agent considered as a treatment for the primary neoplasm =< 28 days or within 4 half-lives (whichever is shorter) of the agent prior to registration Receiving any other investigational agent, which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm; patients must be >= 2 weeks from prior anti-lymphoma therapy; the use of steroids and/or rituximab up to 1 week prior to registration for management of symptoms is allowed Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Currently receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent =< 4 weeks prior to registration which would be considered as treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent that would be considered a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent that would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Currently receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm Patients who are receiving any other investigational agent(s) Patients who are currently receiving any other investigational agent Patient is currently receiving or has received another investigational agent within 4 weeks prior to day 1 of study Patients may not be receiving any other concurrent investigational agents, or have received any investigational agent within four weeks of commencing this protocol. Patients who are currently receiving another investigational agent are excluded Patients may not be receiving any other investigational agent Receiving any other agent which would be considered as a treatment for the lymphoma Currently receiving any other investigational agent or received an investigational agent within last 30 days of study entry. Patient is currently receiving or has received another investigational agent within 4 weeks prior to study day 1 Receiving other investigational agent concomitantly Patients who are receiving any other investigational agents, or have received an investigational agent within the past 30 days Receiving any other investigational agent that would be considered as a treatment for the lymphoma Patients who are currently receiving another investigational agent are excluded Receiving any approved or investigational anti-cancer agent other than those provided for in this study Participants who are receiving an investigational agent(s) Patients receiving another investigational agent Receiving any other investigational agent(s) or has received an investigational agent within the last 30 days Receiving any other investigational agents, or has received an investigational agent within the last 30 days Patient is currently receiving or has received another investigational agent within 4 weeks prior to day 1 of study Patients receiving any other investigational agent (s) Receiving any other investigational agent Patients who are currently receiving any other investigational agent Patients must not be receiving any other investigational agent Receiving other investigational agent At least 21 days have passed since receiving any investigational agent at the time of registration Patients who are receiving any other investigational agents, or have received an investigational agent within the past 30 days Currently receiving an investigational agent Receiving or less than 21 days since receiving any other concurrent cytotoxic, biologic agent(s) or investigational agent PHASE I: Patients who are receiving any other investigational agent PHASE II: Patients who are receiving any other investigational agent Receiving any other investigational agent(s) or has received an investigational agent within the last 30 days Receiving any other investigational agent(s) or has received an investigational agent within the last 30 days Currently receiving any other investigational agents, or received an investigational agent within 3 weeks of the first dose of nintedanib Receiving any other investigational agent(s) or has received an investigational agent within the last 30 days Patients who are receiving any other investigational agent Receiving any other investigational agent which would be considered as a treatment for the lymphoma Receiving any other investigational agent Patient is receiving any other investigational agent Patients who are receiving any other concurrent investigational agents (patients are eligible to enroll 4 weeks after completion of prior agent) Patients must not be receiving any other investigational agent Receiving any other investigational agent Patients who were currently receiving any other investigational agent. Patients receiving other investigational agent Currently receiving another investigational agent Receiving any other concurrent cytotoxic, biologic agent(s) or investigational agent Receiving another investigational agent (30 day wash-out required prior to first dose) Patients that are receiving any other investigational agent Receiving any investigational agent currently, or within 2 weeks of day 1 of treatment on this study Patients receiving an investigational agent within 30 days before enrollment Currently receiving a study therapy or if they had an investigational agent within 4 weeks at the time of enrollment. Patients must not be receiving any other investigational agent Patients may not be receiving any other investigational agent with therapeutic anticancer intent Receiving any other investigational agents or receipt of another investigational agent within 4 weeks of study entry Patients may not be receiving nor have received any other investigational agent =< 4 weeks prior to study registration Patients who are receiving any other investigational agent Patients who are receiving any other investigational agents; if the patient received a previous investigational or other agent or treatment, a washout period of 4 weeks is required Receiving other investigational agent Patients receiving other investigational agent Patients receiving any other current investigational therapeutic agent. Receiving any other investigational agent Patients may not be receiving any other investigational agent with therapeutic anticancer intent The participant is receiving any other investigational agent(s) Patients receiving any other investigational agent(s) Patients may not be receiving any other investigational agent Receiving any other investigational agent Receiving any approved or investigational anti-cancer agent other than those provided for in this study Receiving erythropoietin stimulating agent Receiving any agent classified as an antioxidant Patient who is receiving investigational agent(s) as part of another clinical study at the time of screening or who anticipates receiving investigational agent(s) during their scheduled radiotherapy and concomitant daily temozolomide therapy (e.g. through the BMX001, MRZ 112, and BMX 209-548 studies) Patient must not be receiving any other anti-cancer agent The participant is receiving any other investigational agent(s). The participant is receiving any other investigational agent(s). Patients must not currently be receiving any other investigational agents Patients who are currently receiving other anticancer agents Subject is currently being treated with other investigational agents. Currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving radiotherapy, biological therapy, or any other investigational agents Currently receiving any investigational agents within the previous six weeks or received any tumor vaccines within the previous 6 weeks Currently receiving any other investigational agents EXCLUSION - TREATMENT: Currently receiving any investigational agents or having received any tumor vaccines within the previous 6 weeks Currently receiving any other investigational agents EXCLUSION CRITERIA FOR REGISTRATION: Currently receiving any other investigational agents or systemic cancer therapy TREATMENT EXCLUSION: Currently receiving any investigational agents or received any tumor vaccines within the previous six weeks Currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving any other investigational agents Patients who are currently receiving or have previously received any other investigational agents within 3 weeks prior to entering the study Currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving any other investigational agents or received any within the past 28 days Patients who are currently receiving any other investigational agents. Subjects who are currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving investigational agents that are intended as treatments of recurrent GBM. Currently receiving any other investigational agents Currently receiving any investigational agents Currently receiving any other investigational agents Currently receiving any investigational agents Currently receiving radiotherapy, biological therapy, or any other investigational agents Currently receiving any other investigational agents TREATMENT: Currently receiving any investigational agents or have received any tumor vaccines or T cell antibodies within previous 4 weeks Currently receiving any other investigational agents that are intended as treatments of the relapsed tumor Currently receiving any other investigational agents Patients who are receiving concurrent chemotherapy, or who are currently receiving other investigational chemotherapeutic agents or concurrently receiving radiation Currently receiving any other investigational agents Currently receiving any investigational agents or received any tumor vaccines within the previous 6 weeks Currently receiving any investigational agents or received any tumor vaccines within the previous six weeks Participants who are currently receiving any other investigational agents. Currently receiving any other investigational agents, or exposure to any investigational drug or placebo within 4 weeks of study treatment Currently receiving any other investigational agents Currently receiving any other investigational agents. Patients may not currently be receiving any other investigational agents for leukemia Patients currently receiving other investigational agents Currently receiving any investigational agents or have received any tumor vaccines within the previous six weeks Currently receiving any other investigational agents Receiving any investigational agents currently or within 30 days prior to study screening Currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving any investigational agents or have received any tumor vaccines within previous 4 weeks Currently receiving any investigational agents or received any tumor vaccines within the previous six weeks Currently receiving any other active investigational agents Currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving investigational agents Currently receiving any other investigational agents that are intended as treatments of GBM Patients who are currently receiving any other investigational agents. Currently receiving any investigational agents or registration on another therapy based trial Currently receiving any other investigational agents Participants who are currently receiving any other investigational agents Receiving any other investigational agents currently, or within time limits specified above prior to study day 1 Other investigational agents currently or within 30 days prior to study enrollment Patients who are currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving any other investigational agents that are intended as treatments of recurrent GBM Patients currently receiving other investigational agents Currently receiving any other investigational agents Currently receiving any other investigational agents Currently receiving any other investigational agents Patients currently receiving any other investigational agents; Currently receiving investigational agents in a clinical trial Currently receiving investigational agents in a clinical trial Participants who are currently receiving any other investigational agents or have received investigational agents within the past 3 months will be excluded Patients may not be currently receiving any other investigational agents within 4 weeks of study registration Patients must not currently be using other investigational agents Have received any investigational agent with known anti-CMV activity within 30 days before initiation of study treatment or CMV vaccine at any time. Have received any investigational agent with known anti-CMV activity within 30 days before initiation of study treatment or investigational CMV vaccine at any time. Subjects who have received any anti-CMV therapy and investigational anti-CMV drugs at any time posttransplant. Subjects who have had any anti-CMV vaccine at any time. Any prior investigational CMV vaccine Any prior investigational CMV vaccine Any prior investigational CMV vaccine RECIPIENT: Any prior investigational CMV vaccine Has, is, or is planning (during the study) to participate in any study involving administration of a CMV vaccine or another CMV investigational agent Participants who are receiving or have received any other investigational agents within 14 days of enrollment Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents during the proposed treatment cycle. Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants may not be receiving any other investigational agents Participants may not be receiving any other investigational study agents or treatment for their cancer Participants may not be receiving any other investigational agents Participants who are receiving any other investigational agents. Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents within 21 days of the first dose of study drug Participants who are receiving any other investigational agents Participants may not be receiving any other investigational agents Participants who are receiving any other investigational agents STRATUM A: Participants receiving any other investigational agents STRATUM B: Participants receiving any other investigational agents STRATUM C: Participants receiving any other investigational agents Participants may not be receiving any other investigational agents targeting histiocytosis Participants who are receiving any other investigational agents, or any other anti-cancer therapy during study treatment Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants may not be receiving any other investigational agents Participants may not be receiving any other investigational agents Participants may not be receiving any other investigational agents Participants may not have received any other investigational agents in the previous 3 months Participants who are receiving any other investigational agents Participants who are receiving any investigational agents are not eligible Participants receiving any other investigational agents Participants may not be receiving any other investigational agents Participants who are receiving any other investigational agents Participants may not be receiving any other investigational agents for treatment of their cancer Participants may not be receiving any other investigational agents Participants who are receiving any other investigational agents Participants receiving any other investigational agents Participants who are receiving any other investigational agents after ASCT Participants may not be receiving any other investigational agents nor have participated in an investigational trial within the past 4 weeks Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents within 14 days before the first dose of study drug Participants may not be receiving any other investigational agents Participants who are receiving any other investigational agents PHASE II: Participants may not be receiving any other investigational agents Participants may not be receiving any biologics or investigational agents within 3 weeks Participants receiving any other investigational agents Participants who are receiving any other investigational agents Participants may not be receiving any other investigational anticancer agents Participants may not be receiving any other investigational agents Participants may not be receiving any other investigational agents Participants who are receiving concurrent therapy with other investigational agents Participants may not be receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants receiving any other anti-cancer or investigational agents Participants may not be receiving other investigational agents. Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants who are receiving any other investigational agents Participants may not be receiving any other investigational agents within 30 days of enrollment or during this study Participants who are receiving any other investigational agents Research participants receiving any other investigational agents Participants who are receiving any other investigational agents; participants who are receiving standard of care induction therapy on a clinical trial may be eligible after discussion with the overall principal investigator Participants who are receiving any other investigational agents Participants receiving any other investigational agents Participants who are receiving any other investigational agents within 4 weeks prior to enrollment; investigational antiretroviral agents for HIV are acceptable Participants may not be receiving any other investigational agents for treatment of GVHD or underlying disease for at least 7 days Participants may not be receiving investigational agents Participants may not be receiving any other investigational agents Participants may not be receiving any other investigational agents Participants may not be receiving any other investigational agents Participants who are receiving any other investigational agents Participants receiving any other investigational agents Participants may not be receiving any other investigational agents Participants may not be receiving any other investigational agents within past 3 months Participants may not have received any other investigational agents in the previous 3 months Participants may not be receiving any other investigational agents Participants may not be receiving any other investigational agents during the study Participants may not be receiving any other investigational agents Participants may not be receiving any other investigational agents Participants who are receiving any other investigational agents Participants receiving other investigational agents Participants who are receiving any other investigational agents