Glomerular Filtration Rate >= 60 mL/min (according to Modification of Diet in Renal Disease [MDRD] formula or Cockroft & Gault formula) Glomerular filtration rate (GFR) >= 60 ml/min/1.73 m^2 according to the Modified Diet in Renal Disease (MDRD) abbreviated formula Glomerular filtration rate (GFR) ? 30 mL/min/1.73 m2 according to the modified diet in renal disease (MDRD) abbreviated formula Modification of diet in renal disease (MDRD) calculated glomerular filtration rate (GFR) < 30 mL/min FULL STUDY INCLUSION CRITERIA: Glomerular filtration rate (GFR) >= 30 mL/min/1.73 m^2 according to the Modification of Diet in Renal Disease (MDRD) abbreviated formula Estimated glomerular filtration rate (GFR) by Modification of Diet in Renal Disease (MDRD) formula > 40 mL/min/1.73 m^2 Glomerular filtration rate (GFR) > 60 as defined by the Modification of Diet in Renal Disease (MDRD) formula Glomerular filtration rate (GFR) ? 30 mL/min/1.73 m2 according to the Modification of Diet in Renal Disease (MDRD) formula. Glomerular filtration rate (GFR) >= 30 ml/min/1.73 m^2 according to the Modified Diet in Renal Disease (MDRD) abbreviated formula Estimated glomerular filtration rate (eGFR) > 30 (milliliter per minute (mL/min) /1.73 square meter (m^2) as assessed by Modification of Diet in Renal Disease (MDRD) formula for subjects >= 18 years of age or Schwartz formula for subjects less than (<) 18 years of age. Glomerular filtration rate (GFR) must be greater than or equal to 30 mL/min/1.73 m2 according to the Modified Diet in Renal Disease (MDRD) abbreviated formula. Glomerular filtration rate (GFR) ? 60 mL/min/1.73 m2 according to the Modified Diet in Renal Disease (MDRD) abbreviated formula. Glomerular filtration rate (GFR) >= 30 ml/min/1.73 m^2 according to the MDRD (modified diet in renal disease) abbreviated formula Glomerular filtration rate >/= 30 ml/min/1.73 m2 according to the Modification of diet in renal disease study equation. Glomerular filtration rate > 30ml/min/1.73 m2 according to the Modified Diet in Renal Disease abbreviated formula or creatinine clearance (CrCL) > 60 ml/min (Cockcroft and Gault) Must have estimated glomerular filtration rate (eGFR) by Modification of Diet in Renal Disease (MDRD) formula or Cockroft-Gault formula of 50 mL/min or higher Subjects must have adequate kidney function, as assessed by the estimated glomerular filtration rate (eGFR) >=60 mL/min per 1.73 m*2 [Common Terminology Criteria for Adverse Events(CTCAE Grade <=1)] calculated by the Modification of Diet in Renal Disease Study Group (MDRD) formula Estimated glomerular filtration rate (eGFR) ? 60 mL/min per 1.73 m2 according to the Modification of Diet in Renal Disease Study Group (MDRD) formula (see Section 14.6) Glomerular filtration rate>/=30 mL/min/1.73 m2 according to the Modified Diet in Renal Disease abbreviated formula Glomerular Filtration Rate ? 60 mL/min (according to Modification of the Diet in Renal Disease (MDRD) formula or cockroft & Gault formula) Estimated glomerular filtration rate (eGFR) >/=50 mL/min per 1.73 m2 according to the Modification of Diet in Renal Disease Study Group (MDRD) formula Renal: estimated glomerular filtration rate (eGFR) using the modification of diet in renal disease (MDRD) formula ? 50 mL/min; Glomerular filtration rate (GFR) greater than or equal to 30 ml/min/1.73 m^2 by modification of diet in renal disease (MDRD) Modification of diet in renal disease (MDRD) calculated glomerular filtration rate (GFR) < 30 mL/min Subjects must have a serum creatinine < 2.0 mg/dL and/or calculated glomerular filtration rate (GFR) 50 ml/min/1.73 m^2 (Modification of Diet in Renal Disease [MDRD] formula) or greater Estimated glomerular filtration rate (eGFR) ? 40 mL/min per 1.73 m^2 according to the Modification of Diet in Renal Disease Study Group (MDRD) formula Creatinine clearance > 50 mL/min (calculated according to institutional standards or using Cockcroft-Gault or Modification of Diet in Renal Disease [MDRD] formula) Estimated glomerular filtration rate (eGFR) >= 45 mL/min/1.73 m^2 as calculated using the modification of diet renal disease equation Acceptable renal function with serum creatinine ? 1.5 x ULN or a calculated creatinine clearance ? 50 mL/min using the Cockcroft-Gault or Modification of Diet in Renal Disease formulas. Acceptable renal function with serum creatinine ? 1.5 x ULN or a calculated creatinine clearance ? 60 mL/min using the Cockcroft-Gault or Modification of Diet in Renal Disease formulas. Calculated creatinine clearance by Modification of Diet in Renal Disease (MDRD) (CrCl) >= 60 ml/min/1.73 squared meter Acceptable renal function with serum creatinine ? 1.5 x ULN or a calculated creatinine clearance ? 60 mL/min using the Cockcroft-Gault or Modification of Diet in Renal Disease formulas. Creatinine: glomerular filtration rate (GFR) > 30 as calculated by modification of diet in renal disease (MDRD) equation Adult population (patients >= 18 years): Serum creatinine =< 1.0 mg/dL; if serum creatinine > 1.0 mg/dL, then the estimated glomerular filtration rate (GFR) must be > 60 mL/min/1.73 m^2 as calculated by the Modification of Diet in Renal Disease equation Serum creatinine =< 2 mg/dL or calculated creatinine clearance of >= 40 ml/min within 14 days of registration using Modification of Diet in Renal Disease (MDRD) formula Serum creatinine > 1.5 x the ULN or an estimated glomerular filtration rate (eGFR) calculated using the Modification of Diet in Renal Disease (MDRD) equation of < 45 mL/min/1.73 m^2 Creatinine =< 2.0 mg/dL; however, patients with a creatinine > 2.0 mg/dL but with a calculated creatinine clearance of > 30 ml/min, as measured by the Modification of Diet in Renal Disease (MDRD) equation, will be eligible Creatinine clearance (CrCl) >= 40 ml/min; CrCl will be calculated using the modification of diet in renal disease (MDRD) equation Normal serum creatinine, or a creatinine clearance >= 40 ml/min (either measured using a 24 hour urine, calculated using Cockroft-Gault, or estimated using the Modification of Diet in Renal Disease [MDRD] method from the National Kidney Disease Education Program [NKDEP] [the method reported by M D Anderson Cancer Center (MDACC) laboratories]) DONOR: Serum creatinine within normal limits or a minimum creatinine clearance (CrCl) value of >= 60 ml/min calculated using the Modification of Diet in Renal Disease (MDRD) study equation Estimated serum creatinine clearance >= 50 ml/min (Modification of Diet in Renal Disease [MDRD] method) and/or serum creatinine =< 1.8 mg/dL An estimated glomerular filtration rate (eGFR) calculated using the Modification of Diet in Renal Disease (MDRD) equation of at least 45 mL/min/1.73 m^2 Adequate renal function with creatinine (Cre) =< 1.5; if greater, then glomerular filtration rate (GFR) > 60 mL/min/1.73 m^2 as calculated by the Modification of Diet in Renal Disease equation Creatinine clearance >= 40 mL/min/m^2 by Cockroft-Gault or Modification of Diet in Renal Disease (MDRD) equation Creatinine =< 1.5 mg/dL; however, patients with a creatinine > 1.5 mg/dL but with a calculated creatinine clearance of > 60 ml/min, as measured by the Modification of Diet in Renal Disease (MDRD) equation, will be eligible Patients with a serum creatinine > 1 are eligible if they have a calculated glomerular filtration rate (GFR) of >= 60 ml/min (i.e. class I or class II chronic kidney disease ) using the Modification of Diet in Renal Disease (MDRD) formula\r\n* Note: Daily creatinine and MDRD formula are only for the 1st induction cycle Serum creatinine =< 1.2 mg/dL or serum creatinine > 1.2 mg/dL and an estimated glomerular filtration rate (GFR) > 60 mL/min/1.73 m^2 as calculated by the modification of diet in renal disease equation Serum creatinine ? 1.5 x ULN or an estimated glomerular filtration rate of > 50 mL/min as calculated by the Modification of Diet in Renal Disease equation. Screening laboratory assessments outside the following limits: Absolute neutrophil count (ANC) <1,000/?l (<1.0 x 109/L) Platelet count <100,000/?l (<100 x 109/L) Hemoglobin <9 g/dL Total bilirubin >1.5 x institutional upper limit of normal (ULN) (i n case of known Gilbert's syndrome, <2 x ULN is allowed) Creatinine Creatinine clearance <30 mL/min (as calculated by Cockcroft-Gault formula or Modification of Diet in Renal Disease [MDRD] formula) Creatinine clearance > 45 mL/min.1.73m^2 as estimated by modified Modification of Diet in Renal Disease (MDRD) equation Serum creatinine < 1.5 x institutional Upper Limit of Normal (ULN) or an estimated glomerular filtration rate (eGFR) of > 50 ml/min as calculated by the Modification of Diet in Renal Disease (MDRD) equation Calculated creatinine clearance (estimated glomerular filtration rate [eGFR]) < 60 ml/min; EGFR values can be determined by either Modification of Diet in Renal Disease (MDRD) or Cockcroft-Gault equation based on the investigator’s discretion Serum creatinine =< 2 mg/dL or calculated creatinine clearance of >= 40 ml/min within 14 days of registration using Modification of Diet in Renal Disease (MDRD) formula Serum creatinine ? 1.5 x institutional ULN or an estimated glomerular filtration rate (eGFR) of > 50 ml/min as calculated by the Modification of Diet in Renal Disease (MDRD) equation. Serum creatinine within normal range for age, or if serum creatinine outside normal range, then renal function (estimated glomerular filtration rate [GFR] by modification of diet in renal disease [MDRD] formula) > 40 mL/min/1.73 m^2 Serum creatinine < 1.5 mg/dL or creatinine clearance greater than or equal to 40 cc/min as defined by Modification of Diet in Renal Disease (MDRD) method from National Kidney Disease Education Program (NKDEP) Serum creatinine =< 1.5 mg/dL; if serum creatinine > 1.5 mg/dL, then the estimated glomerular filtrate rate (GFR) must be > 60 ml/min/1.73 m^2 as calculated by the Modification of Diet in Renal Disease equation Subject has an estimated glomerular filtration rate (eGFr) of < 60ml/min as calculated by the modification of diet Renal disease (MDRD) Equation. Creatinine (Cr) clearance > 50 mL/min by Modification of Diet in Renal Disease (MDRD) calculation Serum creatinine < 1.5 x institutional ULN or an estimated glomerular filtration rate (eGFR) of > 50 ml/min as calculated by the Modification of Diet in Renal Disease (MDRD) equation. Estimated serum creatinine clearance >= 50 ml/min (Modification of Diet in Renal Disease [MDRD] method from National Kidney Disease Education Program, [NKDEP]) and/or serum creatinine =< 1.8 mg/dL Calculated creatinine clearance by Modification of Diet in Renal Disease (MDRD) (CrCL) > 50 ml/min/1.73 squared meter Calculated creatinine clearance (CrCl) >= 50 mL/min (modification of diet in renal disease [MDRD] Formula) Creatinine clearance >= 30 mL/min by Modified Diet in Renal Disease (MDRD) equation or Cockcroft-Gault Renal function at screening and enrollment as defined by the Modification of Diet in Renal Disease (MDRD) equation. Calculated creatinine clearance < 30 ml/min; creatinine clearance will be calculated using the Modification of Diet in Renal Disease (MDRD) method Serum creatinine ? 2 times upper limits of normal or estimated glomerular filtration rate ? 60 mL/min/1.73 meter squared per Modification of Diet in Renal Disease equation (MDRD) Renal insufficiency, preferably determined by creatinine clearance less than (<)40 milliliter per minute (mL/min) measured or estimated using the Modification of Diet in Renal Disease (MDRD), or serum creatinine >177 micromole per liter (?mol/L) Serum creatinine =< 1.5 x the upper limit of normal (ULN) or an estimated glomerular filtration rate (eGFR) calculated using the modification of diet in renal disease (MDRD) equation of at least 45 mL/min/1.73 m^2 Serum creatinine ? 1.5 x institutional upper limit of normal (ULN), or if serum creatinine outside normal range, then glomerular filtration rate (GFR) > 40 mL/min/1.73m^2 as calculated with the 4-parameter Modification of Diet in Renal Disease (MDRD) equation. Renal failure, as determined by estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m^2 by the Modification of Diet in Renal Disease (MDRD) model based on a serum creatinine level obtained within 28 days prior to enrollment Adequate renal function assessed by serum creatinine within reference lab normal limits and creatinine clearance (by Chronic Kidney Disease Epidemiology [CKD-EPI] Collaboration equation) ?60 mL/min. Creatinine clearance < 50 mL/min calculated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation Estimated glomerular filtration rate (eGFR) > 45 mL/min (if eGFR is not included on the clinical lab report,\r\nthe chronic kidney disease epidemiology [CKD-EPI] creatinine calculator may be used) Either an estimated creatinine clearance value of > 50 mL/min as determined by the Chronic Kidney Disease Epidemiology (CKD EPI) or MDRD (Modification of Diet in Renal Disease) formulae or a creatinine clearance value of > 50 mL/min based on a 24 hour urine collection Calculated creatinine clearance >= 30 mL/min by the modified Cockcroft and Gault formula OR glomerular filtration rate >= 30 mL/min/body surface area (BSA) by Modification of Diet in Renal Disease or Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula Creatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR) >= 60 ml/min; CrCl will be calculated by Cockcroft-Gault method; eGFR will be calculated by either of the following well established formulas: modification of diet in renal disease (MDRD) or the chronic kidney disease (CKD)-epidemiology collaboration (EPI) (institutional standard) equations; if calculated CrCl/eGFR is < 60 mL/min, patient will have a 24 hr urine collection to measure CrCl; the measured CrCl must also be >= 60 ml/min Creatinine clearance (CrCl) < 30 ml/min/1.73m^2. Creatinine clearance is estimated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula GFR ?45 mL/min/1.73 m2 calculated by CKD-EPI Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (by the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation) Creatinine >1.5 times ULN or creatinine clearance <50 mL/min (measured or calculated by Chronic Kidney Disease Epidemiology (CKD-EPI) Collaboration equation); confirmation of creatinine clearance is only required when creatinine is >1.5 times ULN. Estimated (by Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] or Cockgroft-Gault equations) or calculated creatinine clearance (CrCl) >= 40 ml/min Creatinine clearance > 50 mL/min (calculated according to institutional standards or using Cockcroft-Gault, Modification of Diet in Renal Disease [MDRD], or Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] formula) Within 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR estimated glomerular filtration rate (GFR) per Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN Calculated (using the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation) or measured creatinine clearance < 75% lower limit of normal (LLN) Estimated glomerular filtration rate (eGFR) (chronic kidney disease [CKD]-epidemiology collaboration [EPI]) >= 50 mL/min/1.73 m^2 TREATMENT: Glomerular filtration rate (GFR) > 30 mL/min (calculated by the Cockcroft-Gault, Modification of Diet in Renal Disease [MDRD] study, or Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] creatinine equations, or equivalent) Creatinine clearance or glomerular filtration rate ?30 mL/min as estimated by the Cockroft-Gault (C-G) or other medically acceptable formulas, such as MDRD (Modification of Diet in Renal Disease) or CKD-EPI (the Chronic Kidney Disease Epidemiology Collaboration). Serum creatinine < 1.5 x upper limit normal (ULN) or estimated glomerular filtration rate (GFR) > 50 mL/min based upon Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation. Patients with estimated GFR between 50 - 60 mL/min at baseline will require a 99mTc-DTPA GFR test and only patients with non-obstructive pathology will be included in the study. Glomerular filtration rate (GFR) ?30 ml/min/1.73 m2 (assessed using the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation) GFR <60 mL/min/1.73 m2 (assessed using the CKD-EPI equation) Creatinine within institutional normal limits or glomerular filtration rate >= 30 mL/min/1.73 m^2 by chronic kidney disease (CKD) epidemiology collaboration (EPI) equation Creatinine clearance >= 50 mL/min by either measured (using the Cockcroft-Gault, Modification of Diet in Renal Disease [MDRD] or Chronic Kidney Disease Epidemiology [CKD-EPI] formula) or calculated clearance (i.e. glomerular filtration rate [GFR]) Estimated glomerular filtration rate (eGFR) >= 50 ml/min/1.73 m^2 using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, obtained within 14 days prior to the first study treatment (cycle 1, day 1) Creatinine clearance or glomerular filtration rate ?30 mL/min estimated by the Cockroft-Gault (C-G) or other medically acceptable formulas such as MDRD (Modification of Diet in Renal Disease) or CKD-EPI (the Chronic Kidney Disease Epidemiology Collaboration). Creatinine clearance < 30 mL/min, not eligible for bisphosphonate; estimated glomerular filtration rate will be calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and/or the Cockcroft-Gault equation Estimated glomerular filtration rate (GFR) ?30 mL/min as assessed by CKD-epi, MDRD or the Cockcroft-Gault Equation Estimated glomerular filtration rate (GFR) (calculated using Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation) >= 30 mL/min/1.73 sq.m. Estimated glomerular filtration rate >= 60 ml/min/1.73m^2 using the chronic kidney disease (CKD)-epidemiology (EPI) equation Absence of renal failure attributed to the plasma cell disorder*: calculated creatinine clearance (according to Cockcroft-Gault method, Modification of Diet in Renal Disease [MDRD], or CKD Epidemiology Collaboration [CKD-EPI] formulae) > 30 mL/min (or alternatively based on standard creatinine level criteria of 2 mg/dl)\r\n* To be determined based on clinical and laboratory assessment by the primary oncologist Serum creatinine > 2.0 x ULN; if creatinine 1.5 - 2.0 x ULN, creatinine clearance will be calculated according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula and patients with creatinine clearance < 30 mL/min should be excluded Creatinine clearance >= 60 ml/min using the Cockcroft-Gault method, Modification of Diet in Renal Disease (MDRD), or Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. If the calculated creatinine clearance (CrCl) based on Cockcroft-Gault method, MDRD, or CKD-EPI is < 60 mL/min, patient will have a 24 hour (hr) urine collection to measure CrCl. Creatinine clearance >= 60 ml/min; creatinine clearance (CrCl) can be measured or estimated using Cockcroft-Gault method, modification of diet in renal disease (MDRD), or chronic kidney disease-epidemiology (CKD-EPI) formulae Estimated glomerular filtration rate >= 60 ml/min/1.73 m^2 using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation Estimated glomerular filtration rate (eGFR) ?25 mL/min/1.73 m2 as estimated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, or measured GFR ?25 mL/min/1.73 m2 Creatinine =< 2 x upper limit of normal, unless there is known chronic kidney disease (CKD) (creatinine must be at baseline for subjects with chronic kidney disease) Serum creatinine > 2 x upper limit of normal, unless there is known CKD (creatinine must be at baseline for subjects with CKD) Creatinine within institutional normal limits or glomerular filtration rate >= 50 mL/min/1.73 m^2 by Chronic Kidney Disease Epidemiology Collaboration (CKD EPI) equation Creatinine clearance (CrCl) of greater than or equal to 40 mL/min. using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula; if the CrCl based on the CKD-EPI formula is < 40 mL/min, the patient will have a 24 hour (hr) urine collection to measure CrCl; the measured CrCl must also be >= 40 ml/min Creatinine =< 1.5 x ULN OR creatinine clearance >= 40 mL/min/1.73 m^2 (calculated using the Chronic Kidney Disease-Epidemiology Collaboration [CKD-EPI] equation or Cockroft-Gault formula) for patients with creatinine levels above institutional normal Preoperative eGFR >= 45 cc/min/1.73 m^2 as measured by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) study equation Severe renal impairment (stage 3B) defined as eGFR < 45 cc/min/1.73 m^2 as measured by the CKD-EPI calculation Have kidney disease, defined as either CKD II-V, determined by estimated glomerular filtration rate (GFR) of < 90 and derived from serum creatinine measurements, or albuminuria/proteinuria, determined by albumin to creatinine ratio or protein to creatinine ratio of > 30 mg/gm within 3 months of recruitment, or on dialysis or having received a kidney transplant or have biopsy proven kidney disease