No other planned concurrent investigational agents or other tumor directed therapy (chemotherapy, radiation) while on study
Patients may not be receiving other therapeutic investigational agents or be receiving concurrent anticancer therapy other than standard androgen deprivation therapy; concurrent treatment with agents to prevent skeletal-related events (such as zoledronic acid or denosumab) will be allowed as long as it was initiated prior to study entry
Patients receiving concurrent therapy for their tumor (i.e. chemotherapeutics or investigational agents)
No other concurrent investigational agents or other meningioma-directed therapy (chemotherapy, radiation) while on study
Concurrent use of other investigational agents
Patients may not receive any concurrent investigational agents while on study
Concurrent use of any other investigational agents
Patients who are receiving concurrent investigational therapy;
Concurrent administration of any other investigational agents
Subject receiving concurrent chemotherapeutics or investigational agents within 30 days of study entry, including gliadel wafers or gliasite application.
Concurrent administration of other cancer specific therapy or investigational agents during the course of this study is not allowed
Concurrent treatment with any other investigational therapeutic agents
No other concurrent chemotherapeutic or investigational agents for this cancer. However, concurrent glucocorticoids are allowed;
Concurrent therapy with other systemic anti-neoplastic or investigational agents
Receiving concurrent investigational therapy
No other concurrent investigational agents are allowed
Concurrent use of other investigational agents
Patients receiving concurrent investigational chemotherapeutic agents
Patients receiving concurrent therapy for their tumor (i.e. chemotherapeutics or investigational agents).
Patients may not be receiving any other investigational agents, or concurrent biological therapy, chemotherapy, or radiation therapy
DONOR: Receiving any investigational agents, or concurrent biological, chemotherapy, immunosuppression or radiation therapy
Patients receiving any concurrent investigational agents
Use of any other concurrent investigational agents or anticancer agents including hormonal therapy, except in the case of prostate cancer patients who are being treated anti-androgen or bone targeting therapies.
Concurrent use of restricted agents
Patients may not be receiving any other investigational agents, or concurrent biological therapy, chemotherapy, or radiation therapy
Patients may not be receiving any other investigational agents, or concurrent biological therapy, chemotherapy, or radiation therapy
Patients may not be receiving any other investigational agents, or concurrent parenteral biological, chemotherapy, or radiation therapy; oral chemotherapeutic agents or biologics - for example ruxolitinib therapy (either past or current exposure) - is allowed
Patients may not be receiving any other investigational agents, or concurrent biological, chemotherapy, or radiation therapy
Patients may not be receiving any other investigational agents, or concurrent biological therapy, chemotherapy, or radiation therapy
Concurrent use of other investigational agents or Optune™ device
Use of any other concurrent investigational agents or anticancer agents including hormonal therapy, except in the case of prostate cancer patients who are being treated with LHRH agonist at the time of trial entry
Concurrent use of any other investigational agents
Current or planned use of other investigational agents, or concurrent biological chemotherapy, or radiation therapy during the study treatment period
Current or planned use of other investigational agents, or concurrent biological, chemotherapy, or radiation therapy during the study treatment period
Patients may not be receiving any other investigational agents, or concurrent biological, chemotherapy, or radiation therapy; may have received an experimental agent prior to enrolling in the trial
Concurrent use of any other investigational agents
Patients may not be receiving any other investigational agents and/or any other concurrent anticancer agents or therapies
The use of other concurrent investigational agents will not be allowed
Concurrent use of other investigational agents
Concurrent use of any other investigational agents
Current or planned use of other investigational agents, or concurrent biological, chemotherapy, or radiation therapy during the study treatment period
Patients may not be receiving any other investigational agents, or concurrent biological, chemotherapy, or radiation therapy
Patients may not be receiving any other investigational agents, or concurrent biological, chemotherapy, or radiation therapy
Patients receiving any other investigational agents, or concurrent chemotherapy, radiation therapy, or immunotherapy
Concurrent administration of any other investigational agents
Patient is receiving any other investigational agents, or concurrent biological, chemotherapy, or radiation therapy
Concurrent treatment with other investigational agents is not permitted
Concurrent use of other investigational agents.
Patients may not receive any other concurrent investigational agents while on study
Concurrent treatment with other investigational agents
Concurrent usage of other investigational agents, chemotherapy, or hormone therapy; prior chemotherapy, hormonal therapy, targeted therapy, and investigational agents are allowed but all toxicities grade >= 2 must have resolved by the time of study commencement (except alopecia)
Patients receiving concurrent therapy for their tumor (i.e. chemotherapeutics or investigational agents) other than temozolomide
Concurrent anti-cancer therapy, including chemotherapy agents, targeted agents, or biological agents not otherwise specified in this protocol
Concurrent use of any other investigational agents.
Concurrent use of any other approved or investigational anticancer agents, including hormonal agents
Use of investigational agents or concurrent anti-cancer treatment within the last 4 weeks of registration
Other concurrent investigational agents;
Research participants receiving any other investigational agents, or concurrent biological, chemotherapy, or radiation therapy
Concurrent therapy with other investigational agents
Patients may not be receiving any other investigational agents, or concurrent biological chemotherapy
Patients receiving concurrent therapy for their tumor (i.e. chemotherapeutics or investigational agents)
Concurrent treatment with other investigational or anti-neoplastic agents
Concurrent use of other investigational agents
ANY concurrent investigational agents
No concurrent methotrexate, thiotepa, cytarabine, or investigational agents
Concurrent use of other anti-cancer therapy including chemotherapy agents, targeted agents, or biological agents not otherwise specified in this protocol
Concurrent treatment with other investigational agents(s)
Patients may not be receiving any other experimental agents and/or any other concurrent anticancer agents or therapies except hormonal maintenance
Patients may not be receiving any other investigational agents and/or any other concurrent anticancer agents or therapies
Use of any other concurrent investigational agents or anticancer agents except for hormonal therapy as outlined in inclusion criteria
Patients receiving concurrent therapy for their tumor (i.e. chemotherapeutics or investigational agents, radiation or immunotherapy) within 4 weeks of the first dose of the study drug
Concurrent use of any other investigational agents on a clinical trial
Is receiving any other concurrent systemic tumor therapy, including hormonal agents and HER-2 inhibitors
No other concurrent investigational agents
Patients who are receiving any other investigational agents with the intent to treat myeloma; permitted concurrent therapies include:\r\n* Bisphosphonates
No concurrent anti-cancer treatment (including topical agents such as imiquimod) or investigational agents
Patient has concurrent use of anti-neoplastic agents including investigational therapy
Patient is receiving concurrent treatment with other investigational agents not allowed as part of the combination regimen in the parental study protocol.
Patients may not be receiving any other investigational agents and/or any other concurrent anticancer agents or therapies except hormonal maintenance treatment for prostate cancer
Concurrent use of investigational agents
Actively receiving any other investigational agents, or concurrent biological, chemotherapy, or radiation therapy
Patients may not be receiving any other investigational agents, or concurrent biological, chemotherapy, or radiation therapy
Concurrent therapy with investigational agents
Concurrent systemic therapy for prostate cancer with investigational agents.
Concurrent use of other anti-cancer therapy, including chemotherapy agents, targeted agents, biological agents, immunotherapy, or investigational agents not otherwise specified in this protocol
Concurrent anticancer therapy (including other investigational agents) with the exception of hormone therapy for prostate cancer.
Patients receiving any other concurrent anticancer or investigational therapy
Concurrent anticancer therapy; however, radiotherapy is allowed
Concurrent therapy: no other concurrent anticancer or investigational therapy permitted except as noted above
No other concurrent anticancer therapy or prior prostate cancer vaccines expressing TARP
Concurrent anticancer therapy (including other investigational agents) with the exception of hormone therapy for breast or prostate cancer; patients that have received treatment for a different cancer previously and have been disease-free for less than one year are excluded
Concurrent therapy with approved or investigational anticancer therapeutics.
No concurrent therapy with approved or investigational anticancer therapeutics
Prior or concurrent treatment with any anticancer agent for the same cancer diagnosis
Any concurrent anticancer therapy
Concurrent treatment with any other anticancer therapy
Concurrent use of conventional or investigational anticancer agents, except hydroxyurea
Concurrent anticancer therapy (including other investigational agents)
Plans for concurrent anticancer therapy except as permitted
Concurrent use of other anticancer approved or investigational agents is not allowed.
Concurrent therapy with approved or investigational anticancer therapy
No concurrent anticancer chemotherapy or local therapy
No other concurrent anticancer therapy
Concurrent anticancer treatment within 28 days before the start of trial treatment
Concurrent therapy with approved or investigational anticancer therapeutic other than steroids
Concurrent treatment with any other anticancer therapy
Concurrent use of other anticancer approved or investigational agents is not allowed.
Concurrent anticancer treatment or immunosuppressive agents
SUB-PROTOCOL AIM A: Concurrent use of any other approved or investigational anticancer agents which would be considered as a treatment for the primary neoplasm
Concurrent therapy with any other investigational anticancer agent
Concurrent treatment with any anticancer agent outside of this protocol
Concurrent therapy with approved or investigational anticancer therapeutic
Concurrent therapy with approved or investigational anticancer therapeutic
Concurrent anticancer therapy or any cytotoxic therapy within 1 month prior to Day 1. Corticosteroid therapy is not allowed except on dosing days;
Other concurrent anticancer therapies.
No other concurrent anticancer therapies or agents
Any concurrent anticancer therapy, excluding hormonal therapy for prostate or breast cancer
Concurrent treatment with any other anticancer therapy
Concurrent anticancer therapy (including other investigational agents), with the exception of hormone therapy for prostate cancer
Patients must not be receiving other investigational agents or concurrent anticancer therapy
No other concurrent anticancer agents
Other concurrent anticancer chemotherapy
Concurrent therapy with approved or investigational anticancer therapeutic other than steroids
Concurrent anticancer therapy
Concurrent chronic immunosuppressive or hormone anticancer therapy (except other physiologic hormone replacement)
Concurrent therapy with approved or investigational anticancer therapeutic other than steroids
Concurrent treatment with other anticancer therapy
Receiving concurrent treatment with other anticancer therapy
Concurrent anticancer therapy (including other investigational agents)
Concurrent therapy with approved or investigational anticancer therapeutic other than steroids
Concurrent therapy with approved or investigational anticancer therapeutics
Concurrent enrollment on a non-chemotherapy treatment trial will be allowed, as long as that trial allows concurrent daily aspirin use
Concurrent therapy with any other investigational drug
Patients may not receive any cancer-directed concurrent therapy, such as concurrent chemotherapy, radiotherapy, or hormonal therapy while on study
Concurrent administration of other anti-cancer therapy during the course of this study is not allowed; note that concurrent use of supportive care medications (e.g. anti-resorptive agents, pain medications) is allowed
Concurrent administration of other cancer specific therapy during the course of this study is not allowed
Concurrent administration of other cancer specific therapy during the course of this study is not allowed
The subject must have completed RT with concurrent TMZ at least 12 weeks prior to the planned start of treatment on this study UNLESS there is pathological verification of recurrent tumor and at least 4 weeks have elapsed since the end of RT with concurrent TMZ.
Concurrent administration of other cancer specific therapy during the course of this study is not allowed
Participation in another concurrent treatment protocol
Any concurrent medications which could interfere with the trial
Concurrent serious infection
Concurrent treatment with any chemotherapeutic agent
MEDICAL HISTORY AND CONCURRENT DISEASES
Concurrent brain-directed therapy
Enrollment in a concurrent clinical study.
Concurrent treatment with non-permitted drugs and other interventions.
Concurrent radiation sensitizing medications concurrent with radiation, per treatment physician
Prior/concurrent radiation therapy allowed
Concurrent treatment with any chemotherapeutic agent.
Concurrent treatment with a non-permitted drug
Concurrent enrollment on another investigational therapy
Concurrent treatment with any other anti-leukemia agent
Concurrent treatment with a non-permitted drug
Concurrent disease - patients under treatment for concurrent medical conditions will be eligible for protocol treatment if, in the opinion of the physician responsible for hyperthermia treatment that the concurrent medical condition will neither interfere with the process of the treatment or patient assessments nor add significantly to the risks or complications of the treatment
Concurrent administration of any other anti-tumor therapy
Patients who are participating in a concurrent treatment protocol
Patients who are participating in a concurrent treatment protocol
SECOND COHORT: Concurrent therapy with enzalutamide will be permitted and is a requirement for enrollment
Note: Concurrent and/or adjuvant chemotherapy does not make a patient ineligible; participation in a concurrent treatment protocol does not make a patient ineligible
Concurrent treatment with another anti-estrogen
Patient with any significant concurrent illness
Concurrent use of bosentan
Concurrent administration of any other antitumor therapy.
Participation in another concurrent treatment protocol
The presence of a concurrent non-appendiceal metastatic cancer
Must be no anticipated need for concurrent radiation therapy during protocol treatment.
Participation in another concurrent treatment protocol
Planned concurrent WBRT
Medical history and concurrent diseases:
Concurrent serious infection
Patients who are participating in a concurrent treatment protocol
See Disease Characteristics PRIOR CONCURRENT THERAPY:
Previous or concurrent cancer except
Concurrent NSAID therapy; washout period of 7 days
Concurrent enrollment in another clinical study
Concurrent use of anticholinergics
Concurrent use of anti-seizure drugs, with the exception of gabapentin for treatment of neuropathy
Any concurrent treatment that would compromise the study including but not limited to:
Concurrent somatostatin analogues are allowed provided that the dose has been stable (+/- 10 mg) for at least 8 weeks
Concurrent use of rifampin or ketoconazole
Concurrent treatment with any cytotoxic therapy
No prior or concurrent systemic or radiation therapy for the treatment of myeloma
Prior or concurrent use of erythropoietin is disallowed
Plan to administer concurrent radiation therapy now or for progressive symptoms during treatment
Concurrent therapy with any other investigational drug
Concurrent therapy given to treat cancer
Concurrent therapeutic intervention (including radiation therapy and NovoTTF).
Concurrent treatment with a non permitted drug
Concurrent spironolactone use
No concurrent herbal or unconventional therapy
Concurrent hormone replacement therapy
Participation in concurrent clinical trials evaluating treatment intervention(s)
Has a serious concurrent medical condition such as:
Medical History and Concurrent Diseases
Concurrent anti-cancer treatment in another investigational trial
Concurrent treatment with non-permitted drugs and other interventions
Patients for whom concurrent Adriamycin or gemcitabine chemotherapy is planned, unless on a concurrent protocol (such as a COG sponsored protocol)
Patient is participating in a concurrent treatment protocol
Concurrent or planned concurrent treatment with anticoagulants such as Coumadin or heparin, except to maintain patency of in dwelling catheters
Prior or concurrent therapy with somatostatin analogs is permitted for patients with secretory NET
Concurrent cancer therapy is not permitted.
Concurrent anti-platelet therapy
Concurrent treatment with any systemic chemotherapeutic agent
Concurrent neurodegenerative disease,
Concurrent investigational therapy given to treat cancer or concurrent participation in another clinical trial involving anti-cancer investigational drug.
Concurrent anti-cancer treatment in another investigational trial
Concurrent therapy with protocol-defined excluded medications
Concurrent treatment with a non-permitted drug
Patients receiving any concurrent immunosuppressants
Participants receiving any other cancer directed concurrent therapy; such as concurrent chemotherapy, radiotherapy, or hormonal therapy; concurrent treatment with bisphosphonates/denosumab is allowed but should be started before starting treatment on study
Concurrent administration of any other anti-tumor therapy
Patient is participating in a concurrent treatment protocol
concurrent use of anti-coagulant drugs
Treatment plan to include delivery of concurrent chemoradiotherapy
Serious concurrent illness:
Patients in cohort 2 being treated with concurrent HER2 therapy must have undergone treatment with the concurrent HER2 therapy selected by their attending physician for at least 3 weeks prior to initiation on this study
Patients who are receiving any cancer-directed concurrent therapy, such as concurrent chemotherapy, radiotherapy, or hormonal therapy while on study; concurrent treatment with bisphosphonates and denosumab is allowed for bony metastases but should be started before the first dose of neratinib
Prior or concurrent exposure to approved or investigational multiple myeloma treatments (concurrent treatment with bone-protecting agents (eg, bisphosphonates, denosumab), or steroids (not exceeding 10 mg prednisone per day or equivalent) are only allowed if given in a stable dose and for a nonmalignant condition; concurrent treatment with erythropoietin-stimulating agents (ESAs) are not allowed.)
Patients must be registered on the study within 5 weeks of completion of concurrent chemoradiation
Concurrent investigational therapy delivered over the period of treatment or observation (28 days post-RT) for dose limiting toxicity
Non-protocol concurrent hormonal therapy is not allowed
Concurrent treatment with a non-permitted drug.
No concurrent enrollment in another therapeutic protocol for the same diagnosis
Subject must understand that while they are on study they cannot have any concurrent curative therapy for their cancer other than what is outlined in the protocol
No other concurrent investigational treatment
A concurrent skin rash or skin condition requiring treatment with a prescription medication
Concurrent neoplasia requiring cytotoxic therapy
Concurrent therapy for cancer
Concurrent neoplasia requiring cytotoxic therapy
Concurrent radiation therapy, except for palliation of a single painful bone lesion or fracture.
Requirement for concurrent systemic glucocorticoid therapy at greater than physiologic replacement doses
Patients are allowed to be on another study concurrent with this protocol
Concurrent serious infection
Concurrent use of QT-prolonging medication
Concurrent treatment for cancer
Concurrent enrollment in another investigational clinical study
Medical History and Concurrent Diseases
Concurrent treatment with relevant doses of systemic glucocorticosteroids.
Significant concurrent disease.
Subjects who are considered to require concurrent therapy with another influenza antiviral medication.
Patients who are participating in a concurrent treatment protocol
Concurrent use of alternative cancer therapies
Concurrent treatment with bisphosphonates is permitted, however treatment must be initiated prior to the first dose of study therapy;
Have a concurrent major debilitating illness,
Concurrent use of bupropion
Previous or concurrent use of flibanserin
Not have: concurrent use of ethyol; severe cognitive compromise; known history of central nervous system (CNS) disease (e.g. brain metastases, seizure disorder); concurrent use of amifostine, concurrent abdominal radiotherapy; concurrent use of quinolone antibiotic therapy; chronic alcoholism (as determined by the investigator); known hypersensitivity to olanzapine; known cardiac arrhythmia, uncontrolled congestive heart failure or acute myocardial infarction within the previous six months; history of uncontrolled diabetes mellitus (stable insulin dose and/or stable oral hypoglycemic agent permitted); or have planned chemotherapy or radiation during the 7 days following study initiation
Receiving concurrent radiation therapy
Concurrent use of somatostatin
Are receiving concurrent radiation therapy (RT)
Concurrent breast related radiation therapy is allowed
Concurrent participation in another chemoprevention trial
Concurrent radiation, chemotherapeutic, or investigational therapy other than transplant related therapy
Concurrent enrollment in LCCC 1404
Concurrent cancer treatment of any kind is allowed, but the participant can also have completed all treatment
Concurrent antiandrogen therapy allowed but not required
Prior/concurrent radiation allowed
Patients receiving concurrent additional biologic therapy
Concurrent participation in other investigational studies allowed
Concurrent diuretic use
Be receiving concurrent radiotherapy or interferon.
Concurrent use of immunosuppressant medications
Concurrent therapy with other seizurogenic medications.
Completion of treatment with standard radiation (with or without concurrent therapy)
Concurrent therapy will be allowed
Patients who are participating in a concurrent treatment protocol
Medical History and Concurrent Diseases
Anti-cancer chemotherapy or biologic therapy if administered prior to the first planned dose of study medication (napabucasin or FOLFIRI) within period of time equivalent to the usual cycle length of the regimen. An exception is made for oral fluoropyrimidines (e.g. capecitabine, S-1), where a minimum of 10 days since last dose must be observed prior to the first planned dose of study medication. Standard dose of bevacizumab (5 mg/kg) may be administered prior to FOLFIRI infusion, per Investigator decision, for as long as permanent decision to include or exclude bevacizumab is made prior to patient randomization. Radiotherapy, immunotherapy (including immunotherapy administered for non-malignant diseaseneoplastic treatment purposes), or investigational agents within four weeks of first planned dose of study medication, with the exception of a single dose of radiation up to 8 Gy (equal to 800 RAD) with palliative intent for pain control up to 14 days before randomization.
The patient has received chemotherapy, radiotherapy (except for palliative reasons), immunotherapy, or targeted therapy for gastric cancer within 3 weeks of study treatment
Anti-cancer treatment including surgery, radiotherapy, chemotherapy, other immunotherapy, or investigational therapy within 14 days of registration
Previous anti-cancer chemotherapy, immunotherapy or investigational agents =< 28 days prior to registration
Participant received anticancer therapy including chemotherapy, immunotherapy, radiotherapy, biologic, or any investigational therapy within 21 days before Study Day 1; participant received palliative radiotherapy or small molecule targeted anti-cancer agents within 14 days of Study Day 1.
Subject has received small molecule therapy, radiotherapy, immunotherapy, monoclonal antibodies, investigational drug, or chemotherapy within 14 days before first dose of study drug, with the exception of hydroxyurea
Chemotherapy, radiotherapy, biologics, and/or other treatment with immunotherapy not completed four (4) weeks prior to first dose of study drug or without complete recovery from all such treatments.
Have discontinued all previous therapies for breast cancer (including chemotherapy, radiotherapy, immunotherapy, and investigational therapy), except for ongoing corresponding combination therapy, for at least 21 days for myelosuppressive agents or 14 days for nonmyelosuppressive agents prior to receiving study drug(s), and recovered from the acute effects of therapy (until the toxicity resolves to either baseline or at least Grade 1) except for residual alopecia or peripheral neuropathy. For Part F and H: concurrent treatment with trastuzumab emtansine (T-DM1) is not allowed.
Completion of all previous therapy (including surgery, radiotherapy, chemotherapy, immunotherapy, or investigational therapy) for the treatment of cancer ?3 weeks before the start of study therapy.
Prior systemic therapy: patients must be at least 2 weeks from prior chemotherapy, biological agents, immunotherapy or any investigational drug product, with adequate recovery of toxicity
Patients must have had no radiotherapy, immunotherapy, chemotherapy or therapy with targeted agents within the last 1 month
Patients who have had prior chemotherapy, immunotherapy, targeted therapy, or radiotherapy within 1 month of enrollment
Patients who have had chemotherapy (e.g., purine analogues, alkylating agents), immunotherapy, radiation therapy, or participation in any investigational drug treatment within 4 weeks of initiation of UC-961, or at any time during the study
Chemotherapy, radiotherapy, biologics, and/or other treatment with immunotherapy not completed 4 weeks prior to first dose of study drug
Patients who are receiving any other investigational or concurrent anticancer treatment (chemotherapy, radiotherapy, immunotherapy, cytokine therapy except erythropoietin) at the time of enrollment except for testosterone lowering therapy in men with prostate cancer
Immunotherapy, chemotherapy, radiotherapy, or investigational therapy within 6 months prior to drug dosing
No prior chemotherapy, immunotherapy, or targeted therapy for the treatment of CLL with the exception of palliative loco-regional radiotherapy and corticosteroids for symptom control
Patients with prior investigational drug, chemotherapy, immunotherapy or any prior radiotherapy (except for palliative bone directed therapy) within the past 28 days prior to the first drug administration except if the investigator has assessed that all residual treatment-related toxicities have resolved or are minimal and feel the patient is otherwise suitable for enrollment
Completion of all previous therapy (including surgery, radiotherapy, chemotherapy, immunotherapy, or investigational therapy) for the treatment of cancer ?1 week before the start of study therapy.
At least 3 weeks between last systemic chemotherapy and planned start of study treatment (4 weeks for prior investigational drugs, immunotherapy, radiotherapy, or biologics) for ovarian cancer
Concurrent use of other anticancer agents including chemotherapy, targeted therapy, radiotherapy or immunotherapy not otherwise specified in the protocol
Other concurrent chemotherapy, immunotherapy, radiotherapy or investigational therapy except for hormonal therapy (e.g., tamoxifen, etc.).
Prior systemic therapy (chemotherapy, biologic, or immunotherapy) for the same OPSCC. Prior chemotherapy, biologic therapy, and radiotherapy is allowed in patients with loco-regional recurrent disease, if administered at least 6 months prior to study enrolment
Major surgery, radiotherapy, chemotherapy, biologic therapy, immunotherapy, experimental therapy within 3 weeks prior to the first dose of the study drug
Treatment with other investigational agents including chemotherapy, immunotherapy, or radiation therapy within a month prior to the start of this clinical trial
Currently receiving chemotherapy, radiation therapy, investigational immunotherapy, or investigational biotherapy for breast cancer
Participants receiving any other investigational agents within 2 weeks of the start of this trial and throughout the duration of this trial; participants receiving anti-cancer treatment (chemotherapy, immunotherapy, biologic therapy, vaccine therapy, or investigational treatment) within 3 weeks prior to first dose of dabrafenib or trametinib; participants receiving proteasome inhibitors or immunomodulatory drugs (–imid), or chemotherapy without delayed toxicity within 2 weeks prior to first dose of dabrafenib or trametinib; treatment by localized radiotherapy is not an exclusion criterion if an interval of at least two weeks between the end of radiotherapy and initiation of protocol therapy is observed
Chemotherapy, biochemotherapy, radiation or immunotherapy or any investigational treatment within 30 days prior to receiving any study drug.
At least 4 weeks from prior chemotherapy, radiotherapy or immunotherapy, or prior investigational agents
Patients must have completed previous cancer-related treatments before enrollment. Any concurrent chemotherapy, radiotherapy, immunotherapy, or biologic, or hormonal therapy for cancer excludes the patient (concurrent use of hormones for noncancer-related conditions [eg, insulin for diabetes or hormone replacement therapy] is acceptable). The following intervals between end of the prior treatment and first dose of study drug must be observed:\r\n* Port-a-cath placement: no waiting required\r\n* Minor surgical procedures: >= 7 postoperative days\r\n* Major surgery: >= 4 weeks\r\n* Radiotherapy: >= 4 weeks\r\n* Chemotherapy: >= 4 weeks\r\n* Immunotherapy or investigational anticancer therapy with agents other than monoclonal antibodies (mAbs): >= 4 weeks\r\n* Immunotherapy or investigational anticancer therapy with mAbs: >= 6 weeks\r\n* Immunosuppressive medication: >= 4 weeks with the exceptions of intranasal or inhaled corticosteroids or systemic corticosteroids at physiologic doses not to exceed 10mg/day of prednisone or equivalent
Patients may not receive other concurrent investigational agent, chemotherapy, radiotherapy, or immunotherapy for CLL; NOTE: Localized radiotherapy to an area not compromising bone marrow function does not apply
Less than 21 days between registration and the last receipt of chemotherapy, biotherapy, immunotherapy, radiotherapy (excluding palliative radiotherapy), or major surgery; prior receipt of immunomodulatory therapy (eg: nivolumab) is permitted, as long as there has been a 21 day washout period following the most recent treatment
Major surgery, radiotherapy, chemotherapy, biologic therapy, immunotherapy, investigational therapy within 3 weeks prior to the first dose of the study drugs
Any other concurrent investigational agent or chemotherapy, radiotherapy, or immunotherapy
The subject has participated or is currently participating in another study of an investigational medicine or medical device (radiotherapy, radio-immunotherapy, biological therapy, chemotherapy), within 4-weeks prior to screening.
Patients receiving concurrent anti-cancer treatment (chemotherapy, investigational agents, immunotherapy, endocrine therapy, or Optune®…)
Patients may not be receiving any other investigational agents, chemotherapy, immunotherapy, radiotherapy, or molecular targeted agents within 4 weeks of the start of the study treatment.
Systemic anti-neoplastic therapies within 4 weeks prior to the initiation of investigational treatment, including chemotherapy, radical radiotherapy, hormonotherapy, biotherapy and immunotherapy;
Any major surgery, radiotherapy, chemotherapy, biologic therapy, immunotherapy, experimental therapy within 2 weeks prior to the first dose of the study drugs
Any major surgery, radiotherapy, chemotherapy, biologic therapy, immunotherapy, experimental therapy within 2 weeks prior to the first dose of the study drugs
Received interferon, cytarabine, or immunotherapy within 14 days, or any other cytotoxic chemotherapy, radiotherapy, or investigational therapy within 28 days prior to receiving the first dose of ponatinib, or have not recovered (> grade 1 by NCI CTCAE, version 4.0) from AEs (except alopecia), due to agents previously administered
Patients receiving any other concurrent investigational agent or chemotherapy, radiotherapy, or immunotherapy
Immunotherapy or chemotherapy with approved or investigational anticancer therapeutics within 4 weeks of first dose
Patients may not be receiving any other concurrent chemotherapy, immunotherapy, or radiotherapy
Any prior therapy for the treatment of pancreatic malignancy (including chemotherapy, immunotherapy, vaccines, monoclonal antibodies, major surgery, or irradiation, whether conventional or investigational).
Patients may not receive concurrent chemotherapy, radiotherapy or immunotherapy, nor have received any investigational agents within 7 days prior to drug sensitivity screening
Patient has received anticancer chemotherapy, TKIs, biologics, immunotherapy, radiotherapy, or investigational treatment within 15 days. (There is no washout for hormonal therapy for breast cancer).
Other concurrent chemotherapy, immunotherapy, radiotherapy or investigational therapy.
Has received chemotherapy (except hydroxyurea), biological therapy, radiotherapy or investigational therapy within 4 weeks before baseline (C1D1).
Prior anti-cancer therapy (chemotherapy, targeted agents, radiotherapy, and immunotherapy) within 14 days except for alkylating agents (e.g., melphalan) within 28 days.
Subject has received small molecule therapy, radiotherapy, immunotherapy, monoclonal antibodies, investigational drug, or chemotherapy within 14 days before first dose of study drug, with the exception of hydroxyurea
ARM A: Other concurrent chemotherapy, immunotherapy, radiotherapy, or investigational therapy
ARM B: Other concurrent chemotherapy, immunotherapy, radiotherapy, or investigational therapy
Prior anti-cancer therapy (chemotherapy, targeted agents, radiotherapy, and immunotherapy) within the prior 21 days except for alkylating agents (e.g. melphalan) within the prior 28 days
Participants unwilling or unable to discontinue use of prohibited therapies, including any cytotoxic chemotherapy, radiotherapy, immunotherapy or biologic agent (approved or investigational) for the treatment of TCC are ineligible
Any other concurrent investigational agent or chemotherapy, radiotherapy, hormonotherapy, or immunotherapy. Exceptions are long-term hormonals for prostate (eg, goserelin) and octreotide for neuroendocrine malignancies
Any other concurrent chemotherapy, radiotherapy, or immunotherapy.
Previous anti-cancer chemotherapy, immunotherapy or investigational agents < 4 weeks prior to the first day of study defined treatment
No prior cytotoxic chemotherapy, radiotherapy, immunotherapy, or radioimmunotherapy
Patients receiving concurrent immunotherapy, or radiotherapy
discontinued all previous therapies for cancer (including chemotherapy, radiotherapy, immunotherapy, and endocrine therapy), except trastuzumab, for at least 21 days for myelosuppressive agents or 14 days for nonmyelosuppressive agents prior to receiving study drug, and recovered from the acute effects of therapy
Completion of all therapy (including surgery, radiotherapy, chemotherapy, immunotherapy, or investigational therapy) for the treatment of cancer ? 4 weeks before the start of study therapy.
Treatment with radiotherapy, chemotherapy, immunotherapy, immunosuppressive therapy, or any investigational anti-cancer agent within 2 weeks prior study start
Patients must not have MDS secondary to treatment with radiotherapy, chemotherapy, and/or immunotherapy for malignant or autoimmune diseases
No anti-cancer treatment including surgery, radiotherapy, chemotherapy, other immunotherapy, or investigational therapy within 14 days before treatment start
Anti-cancer chemotherapy, radiotherapy, immunotherapy, or investigational agents within 7 days of first dose of BBI608 and BBI503. Patients may begin BBI608 and BBI503 on a date determined by the investigator and medical monitor for the sponsor after a minimum of 7 days since last receiving anti-cancer treatment, provided that all treatment-related adverse effects have resolved or have been deemed irreversible
Anti-cancer chemotherapy, radiotherapy, immunotherapy, or investigational agents within 14 days of the first dose of BBI608, except for BBI608 for which a washout period is not required.
Other concurrent chemotherapy, immunotherapy, radiotherapy, or investigational therapy.
Receiving chemotherapy, radiotherapy, biologics, and/or other antitumor treatment with immunotherapy that is not completed at least 3 weeks prior to study entry, unless underlying disease is progressing on therapy
Previous anti-cancer treatment (cytotoxic chemotherapy, immunotherapy, biologic therapy radiotherapy or investigational agents) with therapeutic intent for current breast cancer.
Any other investigational agent or chemotherapy, radiotherapy, or immunotherapy administered within 4 weeks prior to Screening.
Anti-cancer chemotherapy, radiotherapy, immunotherapy, or investigational agents within 7 days of first dose of BBI608. Patients may begin BBI608 on a date determined by the investigator and medical monitor for the sponsor after a minimum of 7 days since last receiving anti-cancer treatment, provided that all treatment-related adverse events (AEs) have resolved or have been deemed irreversible
Have discontinued all previous therapies for cancer (including chemotherapy, radiotherapy, immunotherapy, and investigational therapy) for at least 21 days for myelosuppressive agents or 14 days for nonmyelosuppressive agents prior to receiving study drug.
Have discontinued all previous therapies for cancer (including chemotherapy, radiotherapy, immunotherapy, and investigational therapy) for at least 21 days for myelosuppressive agents or 14 days for nonmyelosuppressive agents prior to receiving study drug, and recovered from the acute effects of therapy (treatment related toxicity resolved to baseline) except for residual alopecia.
Treatment including chemotherapy, chemo-immunotherapy, monoclonal antibody therapy, radiotherapy, high-dose corticosteroid therapy (more than 60 mg prednisone daily or equivalent), or immunotherapy within 21 days prior to enrollment or concurrent with this trial
Participants cannot have received any anti-neoplastic therapy (including radiotherapy, chemotherapy or immunotherapy) after ASCT
Prior chemotherapy, biological therapy, radiation therapy, androgens, thalidomide, immunotherapy, other anticancer agents within 21 days of starting study treatment (not including palliative radiotherapy at focal sites); prior use of an investigational monoclonal antibody therapy within 3 months, or prior use of nitrosoureas or mitomycin C within 6 weeks; patients must have recovered from acute toxicity due to radiotherapy
Have discontinued previous therapies for cancer (including specifically, aromatase inhibitors, anti-estrogens, chemotherapy, radiotherapy, and immunotherapy) for at least 21 days for myelosuppressive agents or 14 days for nonmyelosuppressive agents prior to receiving study drug, and recovered from the acute effects of therapy (until the toxicity resolves to either baseline or at least Grade 1) except for residual alopecia or peripheral neuropathy.
Any major surgery, radiotherapy, chemotherapy, biologic therapy, immunotherapy, experimental therapy within 2 weeks prior to the first dose of the study drugs
Patients who have had prior chemotherapy, biological therapy, radiation therapy, androgens, thalidomide, immunotherapy, other anticancer agents, and any investigational agents within 28 days of starting study treatment (not including palliative radiotherapy at focal sites), or corticosteroids that are prohibited per protocol within 14 days of starting study treatment
Small molecule therapy, radiotherapy, immunotherapy, monoclonal antibodies, or chemotherapy within 2 weeks before first dose of study drug
Most recent chemotherapy, immunotherapy, chemo-immunotherapy, or investigational agents <21 days of the first dose of study treatment. Most recent targeted therapy <14 days of the first dose of study treatment.
Have discontinued previous therapies for cancer (including specifically, aromatase inhibitors, anti-estrogens, chemotherapy, radiotherapy, and immunotherapy) for at least 21 days for myelosuppressive agents or 14 days for nonmyelosuppressive agents prior to receiving study drug, and recovered from the acute effects of therapy (until the toxicity resolves to either baseline or at least Grade 1) except for residual alopecia or peripheral neuropathy
Any investigational agent, chemotherapy, immunotherapy, biologic, hormonal within 28 days of the first dose of study treatment
Anti-cancer chemotherapy, radiotherapy, immunotherapy, or investigational agents within 7 days of the first dose of BBI608.
Subjects who have received any anticancer therapy (including surgery, locoregional, biological, immunotherapy, hormonal, or radiotherapy) within 21 days before the first dose of study drug (28 days for investigational therapies).
Chemotherapy, radiotherapy, biologics, and/or other treatment with immunotherapy not completed 4 weeks prior to first dose of study drug
No previous radiotherapy, surgery, chemotherapy or investigational therapy for the treatment of metastatic disease.
Anti-cancer chemotherapy, radiotherapy, immunotherapy, or investigational agents within four weeks of first dose with the exception for a single dose radiation up to 8 Gray (equal to 800 RAD) with palliative intent for pain control up to 14 days before beginning the administration of BBI503
Anti-cancer chemotherapy, radiotherapy, immunotherapy, or investigational agents within four weeks of first dose with the exception for a single dose radiation up to 8 Gray (equal to 800 RAD) with palliative intent for pain control up to 14 days before beginning the administration of BBI608.
Concurrent adjuvant immunotherapy, chemotherapy, or radiotherapy
Recent therapeutic interventions within 3 (chemotherapy/radiotherapy) to 10 weeks (immunotherapy)
A history of prior radiotherapy, chemotherapy, including infusion or perfusion therapy for current disease or any immunotherapy including tumor vaccines, interferon-alfa, interleukins, levamisole or other biologic response modifiers within the past 4 weeks
Patients receiving any other concurrent investigational agent or chemotherapy, radiotherapy, or immunotherapy
Have discontinued all previous therapies for cancer (including chemotherapy, radiotherapy, immunotherapy, and investigational therapy) with the exception of fulvestrant (for Part G only) for at least 21 days for myelosuppressive agents or 14 days for nonmyelosuppressive agents prior to receiving study drug, and recovered from the acute effects of therapy (treatment related toxicity resolved to baseline) except for residual alopecia
Prior or concurrent chemotherapy, radiotherapy, or immunotherapy for CLL
Requirement to receive other concurrent chemotherapy (excluding combination therapy defined in original protocol), immunotherapy, radiotherapy, or any other investigational drug while on study. Palliative radiotherapy is allowed provided that:
Any other prior, concurrent or planned chemotherapy, immunotherapy, radiotherapy, device, or investigational therapy for this cancer other than those specified in this study.
Major surgery, chemotherapy, radiotherapy, investigational agents or other cancer therapy within 1 week of treatment day 1
Patients who have had anticancer therapy (chemotherapy, immunotherapy, radiotherapy, or investigational therapy) within 2 weeks prior to starting study treatment; hydroxyurea is an exception; administration of hydrea to control high WBC is permitted
28 days for cytotoxic chemotherapy, immunotherapy, whole brain radiotherapy, anticonvulsive therapy, stereotactic radiosurgery and major surgery
Subject has received any agent with antitumor activity (other than an EGFR inhibitor, including a T790M inhibitor) including chemotherapy, radiotherapy, immunotherapy, within 14 days prior to the first dose of study drug (palliative radiotherapy is allowed).
Subject has received any chemotherapy, immunotherapy, vaccines, monoclonal antibodies, whether conventional or investigational, major surgery within 21 days, or radiotherapy within 21 days of treatment in this study, or at any time during the study.
are receiving concurrent chemotherapy, radiotherapy, immunotherapy, biological or hormonal treatment for cancer.
have undergone anticancer therapy including chemotherapy (except for hydroxycarbamide at a maximum daily dose of 3000 mg), endocrine therapy, immunotherapy, or the use of other investigational agents within 4 weeks before study entry.
Prior anti-cancer treatments are permitted (i.e., chemotherapy, radiotherapy, hormonal, or immunotherapy)
Patient must not undergo concomitant radiotherapy, chemotherapy or immunotherapy; patient must not be in concurrent study with other investigational agents
Previous treatment with cytotoxic chemotherapy, immunotherapy, or radiotherapy are permitted, if the last dose was given at least 4 weeks prior to the first dose of ponatinib
Patient has received any systemic therapy (e.g. chemotherapy, targeted therapy, immunotherapy) or radiotherapy for current breast cancer disease before randomization.
A history of prior radiotherapy, chemotherapy, including infusion or perfusion therapy for current disease or any immunotherapy including tumor vaccines, interferon-alfa, interleukins, levamisole or other biologic response modifiers within the past 4 weeks
Chemotherapy, radiotherapy, biologics, and/or other antitumor treatment with immunotherapy that is not completed 4 weeks prior to first dose of study drug.
Discontinuation of all therapy (including radiotherapy, chemotherapy, tyrosine kinase inhibitors (TKIs), immunotherapy, or investigational therapy for the treatment of cancer at least 2 weeks prior to the initiation of study therapy
Received systemic treatment for lymphoma such as chemotherapy, immunotherapy, radiotherapy, investigational agents, or radioimmunotherapy.
Recent chemotherapy, radiotherapy, hormonal therapy, immunotherapy or investigational drugs within 21 days or 5 half-days from enrolment.
Anti-cancer chemotherapy or biologic therapy if administered prior to the first planned dose of BBI608/placebo within period of time equivalent to the usual cycle length of the regimen. An exception is made for oral fluoropyrimidines (e.g. capecitabine, S-1), where a minimum of 10 days since last dose must be observed prior to the first planned dose of BBI608/placebo.Radiotherapy, immunotherapy, or investigational agents within four weeks of first planned dose of BBI608/placebo, with the exception of a single dose of radiation up to 8 Gray (equal to 800 RAD) with palliative intent for pain control up to 14 days before randomization.
Chemotherapy (except hydroxyurea or emergent use of single-agent cytarabine for cytoreduction), radiotherapy, biologics, and/or other treatment with immunotherapy that is not completed 2 weeks prior to first dose of study drug, unless progressive disease is documented; NOTE: hydroxyurea will be allowed during the first cycle of treatment
Immunotherapy or chemotherapy with approved or investigational anticancer therapeutics within 21 days of first dose
Patients must have completed any prior anticancer treatment and must have recovered from any acute toxicities. The period between the last dose of prior treatment and the first dose of study drug treatment must be at least 1 week for radiotherapy and at least 2 to 3 weeks for all other modalities of therapy including chemotherapy, monoclonal antibody therapy, immunotherapy, other investigational drugs, or other kinase inhibitors.
The subject has received anticancer therapy including chemotherapy, immunotherapy, radiotherapy, hormonal, biologic, or any investigational therapy within a period of 28 days prior to the first dose of ABT-414.
Treatment with radiotherapy, chemotherapy, immunotherapy, immunosuppressive therapy, or any investigational agent for the purposes of treating cancer within 2 weeks prior to Cycle 1 Day 1
Concurrent treatment or planned treatment with other anticancer therapy (chemotherapy, immunotherapy, radiotherapy, targeted therapy, gene therapy).
Anti-cancer chemotherapy, radiotherapy, immunotherapy, or investigational agents within four weeks of the first dose of ARQ 092 (within 2 weeks for orally administered drugs)
Any chemotherapy, radiotherapy, immunotherapy, biologic, investigational or hormonal therapy for treatment of lymphoma within 28 days prior to treatment
Requirement to receive concurrent chemotherapy, immunotherapy, radiotherapy (except for pain control) or any other investigational drug while on this study.
Anti-cancer treatment including surgery, radiotherapy, chemotherapy, other immunotherapy, or investigational therapy within 14 days of registration
Chemotherapy, radiotherapy, immunotherapy or other medications intended for antitumor activity
A treatment with any other agent with antitumor activity including chemotherapy, radiotherapy, or immunotherapy
Have completed all cancer-related treatments (i.e., surgery, chemotherapy, radiotherapy, immunotherapy, etc.) except for hormonal therapy and Herceptin at least one year previously
Undergoing cancer treatment (chemotherapy, radiotherapy, and/or immunotherapy)
Anti-cancer chemotherapy, radiotherapy, immunotherapy, or investigational agents within 7 days of first dose provided all treatment-related adverse events have resolved or have been deemed irreversible, with the exception for a single dose radiation up to 8 Gray (equal to 800 RAD) with palliative intent for pain control up to 7 days before beginning the administration of BBI608.
Any major radiotherapy, tumor-directed systemic or immunotherapy within the last 4 weeks for any indication
Have discontinued all previous therapies for cancer (including chemotherapy, radiotherapy, immunotherapy, cancer-related hormonetherapy, and investigational therapy) for at least 21 days for myelosuppressive agents or 14 days for nonmyelosuppressive agents prior to receiving study drug and have recovered from the acute effects of therapy(treatment related toxicity resolved to baseline), except for residual alopecia
Prior chemotherapy, biological therapy, radiation therapy, androgens, thalidomide, immunotherapy, other anticancer agents, and any investigational agents within 14 days of starting study treatment (not including palliative radiotherapy at focal sites)
Anticancer chemotherapy, biologics, immunotherapy, radiotherapy, or investigational treatment within 30 days, except for hormone therapy, which could be given up to 7 days prior to the first dose of poziotinib.