Patient’s baseline imaging must not indicate the presence of tumor invading or encasing any major blood vessels Any aneurysm of the major vessels. The subject has tumor in contact with, invading or encasing any major blood vessels The subject has tumor invading or encasing any major blood vessels The participant has tumor invading or encasing any major blood vessels The participant has tumor in contact with, invading, or encasing major blood vessels or radiographic evidence of significant cavitary pulmonary lesions The subject has tumor invading or encasing any major blood vessels The subject has tumor invading or encasing any major blood vessels The subject has tumor invading or encasing any major blood vessels Central lung lesions involving major blood vessels (arteries or veins) or a tumor encasing major blood vessels (i.e. carotid artery) Patient has a tumor amenable to injection of Toca 511 (ie, ? 2 cm and not close to or invading major vessels). The subject has tumor in contact with, invading or encasing any major blood vessels Tumor invading or encasing any major blood vessels The subject has tumor abutting, invading or encasing any major blood vessels The subject has tumor in contact with, invading or encasing any major blood vessels The subject has tumor invading or encasing any major blood vessels The subject has tumor in contact with, invading or encasing any major blood vessels The subject has tumor in contact with, invading or encasing any major blood vessels No tumor in contact with, invading or encasing any major blood vessels Tumor in contact with, invading or encasing any major blood vessels found on radiology report The subject has tumor invading (or concern for invasion) major blood vessels The subject has tumor invading (or there is concern for invasion of) major blood vessel The participant has radiographic evidence of cavitating pulmonary lesion(s) or tumor in contact with, invading or encasing major blood vessels The subject has a pulmonary lesion abutting or encasing a major blood vessel Tumor invading a major blood vessel (such as the carotid artery) The subject has tumor in contact with, invading or encasing major blood vessels The subject has tumor invading any major blood vessels Evidence of tumor invading major blood vessels, cavitation of one or more pulmonary tumor mass(es) ortracheo-esophageal fistula The subject has tumor in contact with, invading, or encasing major blood vessels The subject has tumor invading or encasing any major blood vessels The subject has tumor invading major blood vessels The subject has radiographic evidence of cavitating pulmonary lesion(s) The participant has radiographic evidence of cavitating pulmonary lesion(s) The subject has radiographic evidence of cavitating pulmonary lesion(s) The subject has radiographic evidence of cavitating pulmonary lesion(s) The subject has radiographic evidence of cavitating pulmonary lesion(s) NSCLC with evidence of a centrally cavitating lesion The subject has radiographic evidence of cavitating pulmonary lesion(s) Radiographic evidence of cavitating pulmonary lesion(s) The subject has radiographic evidence of cavitating pulmonary lesion(s) The subject has radiographic evidence of cavitating pulmonary lesion(s) The subject has radiographic evidence of cavitating pulmonary lesion(s) The subject has cavitating pulmonary lesion(s) or a pulmonary lesion abutting or encasing a major blood vessel No prior radiographic evidence of cavitating pulmonary lesion(s) Radiographic evidence of cavitating pulmonary lesion(s) The subject has radiographic evidence of cavitating pulmonary lesion(s) The subject has radiographic evidence of cavitating pulmonary lesion(s) Subject has cavitating pulmonary lesion(s) or a pulmonary lesion or tumor abutting or encasing a major blood vessel Radiographic evidence of cavitating pulmonary lesions and tumor adjacent to or invading any large blood vessel unless approved by sponsor. The subject has radiographic evidence of cavitating pulmonary lesion(s) The subject has radiographic evidence of cavitating pulmonary lesion(s) The subject has radiographic evidence of cavitating pulmonary lesion(s) NSCLC with evidence of a centrally cavitating lesion Patients with known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage are NOT eligible for participation\r\n* Lesions infiltrating major pulmonary vessels (contiguous tumor and vessels) are excluded; however, the presence of a tumor that is touching, but not infiltrating, the vessels is acceptable; CT with contrast is strongly recommended to evaluate such lesions\r\n* Large protruding endobronchial lesions in the main or lobar bronchi are excluded; however, endobronchial lesions in the segmented bronchi are allowed\r\n* Lesions extensively infiltrating the main or lobar bronchi are excluded; however, minor infiltrations in the wall of the bronchi are allowed Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels (Note: tumor abutting the vessel is acceptable, but contiguous tumor and vessel is not; CT with contrast is strongly recommended to evaluate such lesions) Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage; Note: lesions infiltrating major pulmonary vessels (contiguous tumor and vessels) are excluded; however, the presence of a tumor that is touching but not infiltrating (abutting) the vessels is acceptable (CT with contrast is strongly recommended to evaluate such lesions); large protruding endobronchial lesions in the mail or lobar bronchi are excluded; however, endobronchial lesions in the segmented bronchi are allowed; lesions extensively infiltrating the main or lobar bronchi are excluded; however, minor infiltrations in the wall of thee bronchi are allowed Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels and/or hemoptysis in excess of 2.5 mL (or one half teaspoon) =< 8 weeks of registration Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage; Note: lesions infiltrating major pulmonary vessels (contiguous tumor and vessels) are excluded; however, the presence of a tumor that is touching but not infiltrating (abutting) the vessels is acceptable (CT with contrast is strongly recommended to evaluate such lesions); large protruding endobronchial lesions in the mail or lobar bronchi are excluded; however, endobronchial lesions in the segmented bronchi are allowed; lesions extensively infiltrating the main or lobar bronchi are excluded; however, minor infiltrations in the wall of the bronchi are allowed Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage\r\n* Large protruding endobronchial lesions in the main or lobar bronchi are excluded; however, endobronchial lesions in the segmented bronchi are allowed\r\n* Lesions extensively infiltrating the main or lobar bronchi are excluded; however, minor infiltrations in the wall of the bronchi are allowed Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels No known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage; patients with lesions infiltrating major pulmonary vessels (contiguous tumor and vessels) are excluded; however, the presence of a tumor that is touching, but not infiltrating (abutting) the vessels is acceptable (computed tomography [CT] with contrast is strongly recommended to evaluate such lesions); patients with large protruding endobronchial lesions in the main or lobar bronchi are excluded; however, endobronchial lesions in the segmented bronchi are allowed Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage\r\n* Note: lesions infiltrating major pulmonary vessels (contiguous tumor and vessels) are excluded; however, the presence of a tumor that is touching, but not infiltrating (abutting) the vessels is acceptable (computed tomography [CT] with contrast is strongly recommended to evaluate such lesions)\r\n** Large protruding endobronchial lesions in the main or lobar bronchi are excluded; however, endobronchial lesions in the segmented bronchi are allowed.\r\n** Lesions extensively infiltrating the main or lobar bronchi are excluded; however, minor infiltrations in the wall of the bronchi are allowed Patient must not have any known endobronchial lesions and/or lesions infiltrating major pulmonary vessels Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels Known endobronchial lesions or involvement of large pulmonary vessels by tumor EXPANSION COHORT ONLY: Known endobronchial lesions or involvement of large pulmonary vessels by tumor Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage. Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage. Patient must not have known endobronchial lesions and/or lesions infiltrating major pulmonary vessels